CN108066224B - Stomach-soothing and ulcer-relieving toothpaste and preparation method thereof - Google Patents
Stomach-soothing and ulcer-relieving toothpaste and preparation method thereof Download PDFInfo
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- CN108066224B CN108066224B CN201810101201.9A CN201810101201A CN108066224B CN 108066224 B CN108066224 B CN 108066224B CN 201810101201 A CN201810101201 A CN 201810101201A CN 108066224 B CN108066224 B CN 108066224B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention provides an stomach ulcer treating toothpaste which comprises the following components in parts by weight: 0.3-0.6 part of stomach ulcer, 0.18-0.33 part of pilose antler grass extract, 0.18-0.33 part of scutellaria baicalensis extract and 73-86 parts of toothpaste matrix; the stomach ulcer is a medicine extracted from liquorice. The Anweiyang toothpaste has good antibacterial, anti-inflammatory and analgesic effects, and has good oral cavity repairing capability due to strong pertinence to inhibition of pathogenic bacteria; meanwhile, the toothpaste has good treatment effect on stomatitis such as oral ulcer and gingival swelling and pain, is scientific and reasonable in formula, has the synergistic effect of three traditional Chinese medicines, and is low in raw material cost and high in cost performance. The invention also provides a preparation method of the Anweiyang toothpaste, which can fully extract and protect effective antibacterial and bactericidal components in Anweiyang, savatier monochasma herb and baical skullcap root, and ensure that effective components in the toothpaste can play the role of inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating oral inflammation.
Description
Technical Field
The invention relates to the technical field of oral care and health care, in particular to an Anweiyang toothpaste and a preparation method thereof.
Background
Oral inflammation mainly includes ulcerative, herpetic and mycotic stomatitis, oral lichen planus and the like. There is a high possibility of coexistence of various oral inflammations. Among them, recurrent oral ulcer has a high incidence rate and is characterized by periodicity, recurrence and self-limitation. Severe oral ulcer patients may also be accompanied by complications such as swelling and aching of the gums, bleeding gums, and the like. As a common oral disease, oral ulcer is caused by virus or bacteria, generally caused by streptococcus, staphylococcus aureus and escherichia coli, is related to the reduction of autoimmunity, is a localized ulcer injury of oral mucosa characterized by periodic and repeated outbreak, and can occur at any part of the oral mucosa.
Along with the enhancement of health consciousness and the improvement of life quality of people, more and more consumers tend to use functional toothpaste which has certain functionality and can solve and improve oral inflammation problems such as oral ulcer, and the Chinese herbal medicine toothpaste containing natural plant extracts is popular among consumers due to warm nature, small stimulation, safety and no toxic or side effect.
In the traditional Chinese medicine toothpaste in the current market, a part of toothpaste has single traditional Chinese medicine type and single function, and does not exert the synergistic effect generated by the mutual compatibility of traditional Chinese medicines; one part is that the traditional Chinese medicine prescription has too many traditional Chinese medicines, which leads to complex composition of the ingredients and causes the content of the limited active ingredients in the toothpaste to be lower. In addition, the antibacterial active ingredients used by the toothpaste have weak pertinence and broad-spectrum antibacterial property, namely, the toothpaste also has an inhibiting effect on nonpathogenic resident bacteria in the oral cavity and reduces the self-healing capacity of each tissue of the oral cavity to injury.
Therefore, there is a need for a traditional Chinese medicine toothpaste with simple formula and capable of safely and effectively preventing and treating oral inflammation.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the toothpaste which takes gastric ulcer as a main drug and is added with the extract of the cervus elaphus linnaeus and the extract of the scutellaria baicalensis, the toothpaste for gastric ulcer has good antibacterial, anti-inflammatory and analgesic effects, and has better oral cavity repair capacity due to strong pertinence to inhibition of pathogenic bacteria; meanwhile, the toothpaste also has good treatment effect on stomatitis such as oral ulcer and gingival swelling and pain, and has the advantages of scientific and simple formula, low raw material cost and high cost performance.
In order to achieve the purpose, the invention provides the following technical scheme:
the stomach ulcer relieving toothpaste is characterized by comprising the following components in parts by weight: 0.3-0.6 part of stomach ulcer, 0.18-0.33 part of pilose antler grass extract, 0.18-0.33 part of scutellaria baicalensis extract and 73-86 parts of toothpaste matrix;
the stomach ulcer is a medicine extracted from liquorice.
As further description of the technical scheme of the invention, the toothpaste matrix comprises the following components in parts by weight: 27-32 parts of an abrasive, 14-17 parts of an excipient, 28-31 parts of a humectant, 1.2-1.6 parts of a thickening agent, 0.5-1.1 parts of essence, 1.3-1.8 parts of a foaming agent, 1.0-1.5 parts of a sweetening agent and 0.05-0.2 part of a breath freshener.
As further description of the technical scheme of the invention, the composition comprises the following components in parts by weight: 0.5 part of gastric ulcer, 0.24 part of savatier monochasma herb extract, 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix;
the toothpaste matrix comprises the following components in parts by weight:
30 parts of an abrasive, 15 parts of an excipient, 30 parts of a humectant, 1.4 parts of a thickener, 0.8 part of essence, 1.4 parts of a foaming agent, 1.2 parts of a sweetening agent and 0.2 part of a breath freshener.
As a further description of the technical solution of the present invention, in the toothpaste base, the abrasive is one or a mixture of any several of silica, calcium carbonate, calcium bicarbonate and calcium hydrogen phosphate dihydrate; the excipient is sorbitol; the humectant is one or a mixture of any more of glycerol, propylene glycol, polyethylene glycol and sorbitol; the thickening agent is silicon dioxide; the essence is any one of rhizoma zingiberis essence, bamboo leaf essence, spearmint essence and strawberry essence; the foaming agent is sodium lauryl sulfate; the sweetener is saccharin sodium or aspartame; the breath freshener is lemon extract or bamboo leaf extract.
In the invention, the gastric ulcer is a medicament extracted from liquorice, the main component of the gastric ulcer is a liquorice flavonoid compound, and the gastric ulcer also contains multiple active ingredients such as glycyrrhizic acid, glycyrrhetinic acid and the like. The Glycyrrhrizae radix has antiviral, antibacterial, antiulcer, and antioxidant effects. The Anweiyang extracted from licorice has the effects of invigorating spleen and replenishing qi, detoxifying and promoting granulation, inhibiting gastric secretion, repairing and protecting gastric mucosa, is suitable for treating gastric and duodenal bulbar ulcer, and can be used for maintaining and treating healed ulcer. Researchers found that in the treatment of gastric ulcer, the anti-inflammatory basic substances are mainly liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, licochalcone A and licochalcone B, and the components achieve the anti-inflammatory effect by inhibiting inflammatory mediators, proinflammatory cytokines or improving the immune regulation effect. The invention creatively applies the Anweiyang to the treatment of the dental ulcer, and researches find that the licochalcone A and the licochalcone B have stronger effect on oral pathogenic bacteria and can be used as effective components to be applied to gingivitis resistance, dental plaque resistance and dental calculus resistance.
Meanwhile, isoliquiritigenin, liquiritin and isoliquiritin of gastric ulcer also have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. The antibacterial/antimicrobial activity of isoliquiritigenin, liquiritin and isoliquiritin is attributed to the close relationship between phenolic hydroxyl and protein in the glycoside structure; the isoliquiritigenin, liquiritin and isoliquiritin are combined with proteins of pathogenic bacteria, so that the activity of the pathogenic bacteria is reduced and even lost, and the bacteriostatic effect is achieved.
The pilose antler grass is dry whole plant of hairy antler grass of pilose antler grass of scrophulariaceae, the Latin has the scientific name of monochama saveri Franch, which is also known as thousand years of Chinese mugwort, huperzia serrata, Chinese alpine rush, Chinese pulsatilla root and the like, has the efficacies of clearing away heat and toxic material, cooling blood and stopping bleeding and the like, is clinically used for treating cold, upper respiratory tract infection, gingival swelling and pain and the like, and is one of main components of the Chinese medicinal inflammation-protecting granule. The inventor finds that the water extract of the velvet grass is rich in phenylethanoid glycosides, and simultaneously contains corresponding chlorogenic acid, saponin and flavonoid compounds, and the compounds have good antibacterial effect. Researches show that the phenylethanoid glycosides of the pantoea herb in the extract of the pantoea herb aqueous solution have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. The antibacterial and antimicrobial activities of the pantocrine phenylethanoid glycosides are attributed to the close relationship between the phenolic hydroxyl and the protein, so that in the preparation of the toothpaste, the phenolic hydroxyl of the pantocrine phenylethanoid glycosides can be protected in the water extraction process, and the phenolic hydroxyl is prevented from being damaged by introducing an organic solvent.
The Scutellaria baicalensis is a perennial herb of the genus Scutellaria of the family labiatae, has the Latin scientific name of Scutellaria baicailenis Georgi, is called as camellia root and native gold tea root, is used as a medicine, is bitter in taste and cold in nature, and has the effects of clearing heat, drying dampness, purging fire, detoxifying, stopping bleeding, preventing miscarriage and the like. The inventor finds that the scutellaria baicalensis water extract baicalensis compounds have good antibacterial activity, and particularly, a large amount of baicalein compounds and baicalein glucoside contained in the scutellaria baicalensis water extract have good inhibitory effect on staphylococcus aureus and hemolytic streptococcus.
The invention creatively compounds the antrioon gastric ulcer, the cervicitis pantotrichum extract and the scutellaria baicalensis extract, enhances the inhibition and killing effect on oral pathogenic bacteria, and particularly has obvious inhibition and killing effect on staphylococcus aureus and helicobacter pylori causing oral ulcer symptoms; meanwhile, Anweiyang has the effect of tonifying qi and tonifying deficiency of liquorice, so that the bitter and cool herbs of the pilose antler and the bitter and descending herbs of the baical skullcap root can remove excess heat. The stomach-soothing sore, the herb of pilose antler and the scutellaria baicalensis are reasonably compatible to play a role in synergy, have better oral cavity repairing capability and have good treatment effect on stomatitis such as oral sore, gum swelling and pain and the like.
The toothpaste matrix comprises an abrasive, an excipient, a humectant, a thickener, essence, a foaming agent, a sweetening agent and a breath freshening agent, and the matrix components are preferably used as carriers of the gastric ulcer, the antlerpilose grass and the scutellaria baicalensis according to the proportion, so that the traditional Chinese medicine components in the raw materials can be fully mixed and dissolved, the paste is fine, compact, bright and uniform in color distribution, and the quality of the paste is further improved.
The matrix is added with the breath freshener, the lemon extract or the bamboo leaf extract is selected, the lemon extract or the bamboo leaf extract has antibacterial components and corresponding curative effects, the effects of relieving toothache and nourishing gums can be achieved, meanwhile, the lemon extract or the bamboo leaf extract can solve the problem of dead corners of the oral cavity, breath can be removed, and the problem of halitosis for a long time can be solved.
As another object of the invention, the invention also provides a preparation method of the stomach ulcer-relieving toothpaste, which comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract;
(2) conveying the velvet antler grass extract and the scutellaria baicalensis extract obtained in the step 1, the gastric ulcer and the toothpaste matrix into a vacuum mixer according to the weight parts of the components, and stirring and homogenizing to obtain paste; the stirring and homogenizing time is 20-30 minutes;
(3) sterilizing the paste, and packaging with a composite hose to obtain the gastrohelcosis-relieving toothpaste.
In the preparation method, the invention fully extracts and protects the effective antibacterial and bactericidal components in the gastric ulcer, the cervicitis pantotrichum and the scutellaria baicalensis, and has obvious inhibiting and killing effects on staphylococcus aureus and helicobacter pylori causing oral ulcer symptoms.
Based on the technical scheme, the invention has the following technical effects:
(1) the Anweiyang toothpaste provided by the invention has the advantages that the water extracts of the two traditional Chinese medicines of the savatier monochasma herb and the baical skullcap root are reasonably compatible with Anweiyang, the effective components and the action mechanism are relatively clear, the toothpaste has good antibacterial, anti-inflammatory and analgesic effects, and the toothpaste has strong pertinence to the inhibition of pathogenic bacteria and has a small inhibition effect on nonpathogenic resident bacteria, so that the self-healing capacity and the oral cavity repair capacity of oral tissues to injury are effectively improved.
(2) The Anweiyang toothpaste can promote the healing of the wound surface of oral inflammation, thereby having good treatment effect on oral inflammation such as oral ulcer, gum swelling and pain and the like, and having scientific and simple formula, low raw material cost and high cost performance. Compared with the traditional medicinal toothpaste for treating oral ulcer, the toothpaste has the advantages of less side effect and higher safety.
(3) In the Anweiyang toothpaste, Anweiyang has the effect of tonifying qi and tonifying deficiency of liquorice, and the cold and bitter herbs of the pilose antler and the bitter descending of the scutellaria baicalensis can both remove excess heat.
(4) The preparation method of the Anweiyang toothpaste provided by the invention can fully extract and protect effective antibacterial and bactericidal components in Anweiyang, savatier monochasma herb and scutellaria baicalensis, and ensure that effective components in the toothpaste can play the role of inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating oral inflammation. The preparation method has the advantages of low cost of raw materials, simple operation, no influence on the activity of the traditional Chinese medicine components, few process steps and contribution to industrial production.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Example 1
An ulcer-treating toothpaste comprises the following components in parts by weight: 0.5 part of gastric ulcer, 0.24 part of savatier monochasma herb extract, 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix; the stomach ulcer is a medicine extracted from liquorice;
the toothpaste matrix comprises the following components in parts by weight:
30 parts of abrasive silicon dioxide, 15 parts of excipient sorbitol, 30 parts of humectant which is a mixture of propylene glycol and polyethylene glycol, 1.4 parts of thickener silicon dioxide, 0.8 part of essence bamboo leaf essence, 1.6 parts of foaming agent sodium lauryl sulfate, 1.2 parts of sweetener aspartame and 0.2 part of breath freshener bamboo leaf extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract;
(2) conveying the antlerpilose grass extract and the baical skullcap root extract obtained in the step 1, and the antlerpilose grass and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.5 part of the gastric ulcer, 0.24 part of the antlerpilose grass extract, 0.24 part of the baical skullcap root extract and 80 parts of the toothpaste matrix to obtain a paste; the stirring and homogenization time was 26 minutes.
(3) The paste was sterilized and then packaged in a composite tube to obtain the Anweiyang toothpaste of example 1.
Example 2
An ulcer-treating toothpaste comprises the following components in parts by weight: 0.4 part of gastric ulcer, 0.20 part of savatier monochasma extract, 0.20 part of scutellaria baicalensis extract and 75 parts of toothpaste matrix; the stomach ulcer is a medicine extracted from liquorice;
the toothpaste matrix comprises the following components in parts by weight:
31 parts of friction agent calcium hydrophosphate dihydrate, 15 parts of excipient sorbitol, 31 parts of humectant glycerin, 1.4 parts of thickening agent silicon dioxide, 0.8 part of essence and dried ginger essence, 1.6 parts of foaming agent sodium lauryl sulfate, 1.2 parts of sweetening agent saccharin sodium and 0.05 part of breath freshener lemon extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract;
(2) conveying the antlerpilose grass extract and the baical skullcap root extract obtained in the step 1, and the antlerpilose grass and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.4 part of the gastric ulcer, 0.20 part of the antlerpilose grass extract, 0.20 part of the baical skullcap root extract and 75 parts of the toothpaste matrix to obtain a paste; the stirring and homogenization time was 20 minutes.
(3) The paste was sterilized and then packaged in a composite tube to obtain the Anweiyang toothpaste of example 2.
Example 3
An ulcer-treating toothpaste comprises the following components in parts by weight: 0.6 part of gastric ulcer, 0.33 part of savatier monochasma extract, 0.30 part of scutellaria baicalensis extract and 86 parts of toothpaste matrix; the stomach ulcer is a medicine extracted from liquorice;
the toothpaste matrix comprises the following components in parts by weight:
32 parts of abrasive silicon dioxide, 17 parts of excipient sorbitol, 31 parts of humectant sorbitol, 1.6 parts of thickening agent silicon dioxide, 1.1 parts of essence bamboo leaf essence, 1.8 parts of foaming agent sodium lauryl sulfate, 1.5 parts of sweetener aspartame and 0.3 part of breath freshener lemon extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract;
(2) conveying the antlerpilose grass extract and the baical skullcap root extract obtained in the step 1, and the antlerpilose grass and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.6 part of the gastric ulcer, 0.33 part of the antlerpilose grass extract, 0.30 part of the baical skullcap root extract and 86 parts of the toothpaste matrix to obtain a paste; the stirring and homogenization time was 30 minutes.
(3) The paste was sterilized and then packaged in a composite tube to obtain the Anweiyang toothpaste of example 3.
Comparative example 1 (not including Anweiyang component)
The toothpaste comprises the following components in parts by weight: 0.24 part of pilose antler grass extract, 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix;
the toothpaste matrix comprises the following components in parts by weight:
30 parts of abrasive silicon dioxide, 15 parts of excipient sorbitol, 30 parts of humectant polyethylene glycol, 1.4 parts of thickening agent silicon dioxide, 0.8 part of essence bamboo leaf essence, 1.6 parts of foaming agent sodium lauryl sulfate, 1.2 parts of sweetener aspartame and 0.2 part of breath freshener lemon extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract, respectively.
(2) Conveying the pilose antler grass extract and the baical skullcap root extract obtained in the step 1 and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.24 part of pilose antler grass extract, 0.24 part of baical skullcap root extract and 80 parts of toothpaste matrix to obtain paste; the stirring and homogenization time was 26 minutes.
(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 1.
Comparative example 2 (containing no Cervus elaphus Linnaeus extract component)
The toothpaste comprises the following components in parts by weight: 0.5 part of gastric ulcer, 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix;
the toothpaste matrix comprises the following components in parts by weight:
30 parts of abrasive silicon dioxide, 15 parts of excipient sorbitol, 30 parts of humectant which is a mixture of propylene glycol and polyethylene glycol, 1.4 parts of thickener silicon dioxide, 0.8 part of essence bamboo leaf essence, 1.6 parts of foaming agent sodium lauryl sulfate, 1.2 parts of sweetener aspartame and 0.2 part of breath freshener bamboo leaf extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting Scutellariae radix with purified water twice, each time for 1.7 hr, mixing decoctions, filtering, concentrating, and drying to obtain Scutellariae radix extract.
(2) Conveying the scutellaria baicalensis extract obtained in the step 1, the gastric ulcer and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.5 part of gastric ulcer, 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix to obtain paste; the stirring and homogenization time was 30 minutes.
(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 2.
Comparative example 3 (containing no Anweiyang component and Royal Exopaeus extract component)
The toothpaste comprises the following components in parts by weight: 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix;
the toothpaste matrix comprises the following components in parts by weight:
30 parts of abrasive silicon dioxide, 15 parts of excipient sorbitol, 30 parts of humectant polyethylene glycol, 1.4 parts of thickening agent silicon dioxide, 0.8 part of essence bamboo leaf essence, 1.6 parts of foaming agent sodium lauryl sulfate, 1.2 parts of sweetener aspartame and 0.2 part of breath freshener lemon extract.
The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:
(1) decocting Scutellariae radix with purified water twice for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain Scutellariae radix extract.
(2) Conveying the scutellaria baicalensis extract and the toothpaste matrix obtained in the step (1) into a vacuum mixer for stirring and homogenizing according to the weight parts of 0.24 part of scutellaria baicalensis extract and 80 parts of toothpaste matrix to obtain paste; the stirring and homogenization time was 26 minutes.
(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 3.
The anagastric ulcer toothpastes of examples 1 to 3 and the toothpastes of comparative examples 1 to 3 were subjected to efficacy tests.
1. Antibacterial effect test of toothpaste
The bacteriostatic ability of the prepared toothpaste is determined by adopting a filter paper method, and the selected strains are as follows: staphylococcus aureus, helicobacter pylori, escherichia coli, and pseudomonas aeruginosa; the specific test method is as follows: mixing the strain cultured at 37 deg.C for 24 hr with normal saline to make the content of mixed bacteria reach 105cfu/ml; taking 0.1ml of bacterial liquidUniformly coating the beef extract protein solid culture medium with the diluted 6 parts of toothpaste liquid with the concentration of 100mg/ml and sterile filter paper sheets with the diameter of 6mm, respectively taking 5ul of the diluted 6 parts of toothpaste liquid, placing the filter paper sheets on a bacteria coating culture medium, culturing for 24h at 37 ℃, observing the diameter of a bacteriostatic circle, and preliminarily judging the bacteriostatic ability of the sample, wherein' represents that the bacteriostatic circle is less than 1mm, and represents that the toothpaste sample has no bacteriostatic ability. The test results are shown in table 1:
TABLE 1 results of in vitro antibacterial tests of Anweiyang toothpaste of examples 1-3 and toothpaste of comparative examples 1-3
As can be seen from the table 1, the Anweiyang toothpaste compounded by the Anweiyang, the velvet grass extract and the scutellaria baicalensis extract has good bacteriostatic effect on staphylococcus aureus, helicobacter pylori, escherichia coli and pseudomonas aeruginosa, and particularly has obvious inhibiting and killing effects on staphylococcus aureus and helicobacter pylori causing oral ulcer; the toothpaste adopting the water extract of the gastric ulcer or the antlerpilose grass alone or the toothpaste without the extracts of the gastric ulcer and the antlerpilose grass has poor inhibition effect on the 4 bacteria. This verifies that in the Anweiyang toothpaste of examples 1-3, because the Anweiyang, the velvet grass and the Baikal skullcap root have synergistic effects, especially the isoliquiritigenin of Anweiyang and the phenylethanoid glycoside compound of velvet grass are matched with each other, the Anweiyang toothpaste has better oral cavity repairing capability, plays a good role in inhibiting and killing bacteria, and has strong pertinence to the inhibition of pathogenic bacteria.
2. Evaluation of curative effect of toothpaste in preventing and treating dental ulcer
300 volunteers with the same dental ulcer and the same disease date and the same disease degree were selected, wherein 178 men and 122 women were divided into 6 groups of 50 persons, and the toothpaste for the ulcer angustifolia of examples 1-3 and the toothpaste for the comparative examples 1-3 were used respectively once a day in the morning and at night for a period of 7 days for a suitability test.
The evaluation criteria are as follows:
and (3) curing: the ulcer disappears, and the wound healing rate is higher than 90%;
the effect is shown: the pain disappears, and the wound healing rate is 75-90%;
the method has the following advantages: the pain is relieved, and the wound healing rate is 50-75%;
and (4) invalidation: pain persists with a wound healing rate of less than 50%.
The results of the efficacy evaluation are shown in table 2:
TABLE 2 results of the patient suitability test for the Anweiyang toothpaste of examples 1-3 and the toothpaste of comparative examples 1-3
| Treatment groups | Cure of disease | Show effect | Is effective | Invalidation | Effective rate (%) | Cure rate (%) |
| Example 1 | 40 | 3 | 5 | 2 | 96 | 80 |
| Example 2 | 39 | 3 | 4 | 4 | 92 | 78 |
| Example 3 | 37 | 7 | 3 | 3 | 94 | 74 |
| Comparative example 1 | 2 | 6 | 21 | 21 | 58 | 4 |
| Comparative example 2 | 4 | 6 | 20 | 20 | 60 | 8 |
| Comparative example 3 | 1 | 3 | 18 | 28 | 44 | 2 |
As can be seen from table 2, the effective rates of the patients using the anangrexia toothpastes prepared in examples 1-3 are all above 90%, especially the anangyang toothpastes of examples 1 and 2 have cure rates of 80% and 78%, respectively, and the effect of treating oral ulcer is significant. The effect of treating the oral ulcer is not very obvious by singly adopting the antlerpilose grass extract or the toothpaste with the gastric ulcer or the toothpaste without adding the antlerpilose grass extract and the antlerpilose grass extract.
Therefore, the stomach ulcer-relieving toothpaste provided by the embodiments 1 to 3 has the advantages that the three traditional Chinese medicines of stomach ulcer-relieving, savatier monochasma herb and scutellaria baicalensis are reasonably compatible, the effective components and the action mechanism are relatively clear, the toothpaste has good antibacterial, anti-inflammatory and analgesic effects, and the self-healing capability and the oral cavity repairing capability of oral tissues to injuries are effectively improved due to the strong pertinence to the inhibition of pathogenic bacteria and the small inhibition effect on nonpathogenic resident bacteria. The Anweiyang toothpaste provided by the embodiments 1-3 can promote healing of oral inflammation wound surfaces, so that the Anweiyang toothpaste has good treatment effects on oral inflammations such as oral sores and gum swelling and pain, and is scientific and reasonable in formula, low in raw material cost and high in cost performance.
The foregoing is merely exemplary and illustrative of the structures of the present invention, which are described in some detail and detail, and are not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications are possible without departing from the inventive concept, and such obvious alternatives fall within the scope of the invention.
Claims (1)
1. The preparation method of the stomach ulcer preventing toothpaste is characterized in that the stomach ulcer preventing toothpaste comprises the following components in parts by weight:
0.3-0.6 part of stomach ulcer, 0.18-0.33 part of pilose antler grass extract, 0.18-0.33 part of scutellaria baicalensis extract and 73-86 parts of toothpaste matrix;
the gastric ulcer is a medicine extracted from liquorice, the main component of the gastric ulcer is a liquorice flavonoid compound, and the gastric ulcer also contains glycyrrhizic acid and glycyrrhetinic acid active ingredients;
the toothpaste matrix comprises the following components in parts by weight: 27-32 parts of an abrasive, 14-17 parts of an excipient, 28-31 parts of a humectant, 1.2-1.6 parts of a thickening agent, 0.5-1.1 parts of essence, 1.3-1.8 parts of a foaming agent, 1.0-1.5 parts of a sweetening agent and 0.05-0.2 part of a breath freshener;
in the toothpaste matrix, the abrasive is one or a mixture of any of silicon dioxide, calcium carbonate, calcium bicarbonate and calcium hydrophosphate dihydrate;
the excipient is sorbitol;
the humectant is one or a mixture of any more of glycerol, propylene glycol, polyethylene glycol and sorbitol;
the thickening agent is silicon dioxide;
the essence is any one of rhizoma zingiberis essence, bamboo leaf essence, spearmint essence and strawberry essence;
the foaming agent is sodium lauryl sulfate;
the sweetener is saccharin sodium or aspartame;
the breath freshener is a lemon extract or a bamboo leaf extract;
the preparation method comprises the following specific steps:
(1) decocting herba Monochasmatis and Scutellariae radix with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and Scutellariae radix extract;
(2) conveying the velvet antler grass extract and the scutellaria baicalensis extract obtained in the step 1, the gastric ulcer and the toothpaste matrix into a vacuum mixer according to the weight parts of the components, and stirring and homogenizing to obtain paste; the stirring and homogenizing time is 20-30 minutes;
(3) sterilizing the paste, and packaging with a composite hose to obtain the gastrohelcosis-relieving toothpaste.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810101201.9A CN108066224B (en) | 2018-02-01 | 2018-02-01 | Stomach-soothing and ulcer-relieving toothpaste and preparation method thereof |
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| CN201810101201.9A CN108066224B (en) | 2018-02-01 | 2018-02-01 | Stomach-soothing and ulcer-relieving toothpaste and preparation method thereof |
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| CN108066224A CN108066224A (en) | 2018-05-25 |
| CN108066224B true CN108066224B (en) | 2021-08-06 |
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| CN110787078A (en) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | Toothpaste containing licoflavone and preparation method and application thereof |
| CN109223682A (en) * | 2018-11-22 | 2019-01-18 | 广州市名俐日用化工有限公司 | A kind of ginger lemon toothpaste and preparation method thereof that anti-inflammatory is pure and fresh |
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| CN102698121B (en) * | 2012-01-10 | 2013-09-11 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicinal composition for treating paradentitis and preparation method thereof and toothpaste |
| CN105106060A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing arnebia root oil |
| CN105534769A (en) * | 2015-12-22 | 2016-05-04 | 南昌理工学院 | Antibacterial toothpaste containing a baical skullcap root extract product |
| CN107320390A (en) * | 2017-08-09 | 2017-11-07 | 何家平 | A kind of toothpaste containing Chinese herbal medicine |
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