CN110787078A - Toothpaste containing licoflavone and preparation method and application thereof - Google Patents
Toothpaste containing licoflavone and preparation method and application thereof Download PDFInfo
- Publication number
- CN110787078A CN110787078A CN201810947177.0A CN201810947177A CN110787078A CN 110787078 A CN110787078 A CN 110787078A CN 201810947177 A CN201810947177 A CN 201810947177A CN 110787078 A CN110787078 A CN 110787078A
- Authority
- CN
- China
- Prior art keywords
- parts
- licoflavone
- sodium
- toothpaste
- essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 54
- 239000000606 toothpaste Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 54
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- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 34
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- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention provides a toothpaste containing licoflavone, which comprises the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate. The toothpaste takes licoflavone as main drug and is supplemented with toothpaste matrix, and has the advantages of scientific and simple formula, low cost of raw materials, and high cost performance; the toothpaste has strong pertinence to inhibition of pathogenic bacteria, and has good effects of inhibiting bacteria, diminishing inflammation and cleaning oral cavity.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine oral care and health care, in particular to a toothpaste containing licoflavone and a preparation method and application thereof.
Background
Oral ulcer, commonly known as "aphtha", is a common ulcerative injury to the oral mucosa, which is usually found in the inner labial, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate, etc., where the mucosa lacks cutinization layer or has poor keratosis. Tongue ulcer refers to oral ulcer occurring on tongue and tongue abdomen. The pain is severe when the oral ulcer is attacked, the local burning pain is obvious, and serious patients can influence diet and speaking, so that the daily life is inconvenient; can be used for treating halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, asthenia, dysphoria, fever, and lymphadenectasis.
As a common oral disease, oral ulcer is caused by virus or bacteria, generally caused by streptococcus, staphylococcus aureus and escherichia coli, is related to the reduction of autoimmunity, is a localized ulcer injury of oral mucosa characterized by periodic and repeated outbreak, and can occur at any part of the oral mucosa.
Along with the enhancement of health consciousness and the improvement of life quality of people, more and more consumers tend to use functional toothpaste which has certain functionality and can solve and improve oral inflammation problems such as oral ulcer, and the Chinese herbal medicine toothpaste containing natural plant extracts is popular among consumers due to warm nature, small stimulation, safety and no toxicity.
At present, the traditional Chinese medicine toothpaste in the market contains too many traditional Chinese medicine prescriptions, so that the components are complex, and the content of the limited effective components in the toothpaste is lower. In addition, the antibacterial active ingredients used by the toothpaste have weak pertinence and broad-spectrum antibacterial property, namely, the toothpaste also has an inhibiting effect on nonpathogenic resident bacteria in the oral cavity and reduces the self-healing capacity of each tissue of the oral cavity to injury.
Therefore, there is a need for developing a traditional Chinese medicine toothpaste which has a simple formula and can safely and effectively prevent and treat dental ulcer.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the toothpaste containing licoflavone, which takes licoflavone as a main drug and is supplemented with a toothpaste matrix, and has scientific and simple formula, low raw material cost and high cost performance; the toothpaste has strong pertinence to inhibition of pathogenic bacteria, and has good effects of inhibiting bacteria, diminishing inflammation and cleaning oral cavity.
In order to achieve the purpose, the invention provides the following technical scheme:
the toothpaste containing licoflavone comprises the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate.
As further description of the technical scheme of the invention, the toothpaste containing licoflavone comprises the following components in parts by weight: 45 parts of calcium hydrophosphate dihydrate, 3 parts of silicon dioxide hydrate, 2.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 5 parts of hydroxyethyl cellulose, 0.3 part of xanthan gum, 0.15 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 1 part of licoflavone, 0.5 part of glycyrrhizin, 0.1 part of magnolol, 0.1 part of paeonol, 0.5 part of peppermint oil, 0.6 part of essence, 1 part of 1% brilliant blue solution, 0.5 part of eugenol and 0.8 part of sodium monofluorophosphate.
As further description of the technical scheme of the invention, the licoflavone is an active substance which is extracted from the traditional Chinese medicine liquorice by various methods and solvents and takes flavonoid compounds as main components.
The licorice has the functions of resisting virus, bacteria, ulcer and oxidation, and the licorice flavone compounds extracted from licorice have the anti-inflammatory basic material comprising liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, licochalcone A and licochalcone B, which reach the anti-inflammatory effect through inhibiting inflammation medium, proinflammatory cell factor or raising immunity regulating effect. The licoflavone-containing toothpaste is applied to treatment of dental ulcer, wherein licochalcone A and licochalcone B have a strong effect on oral pathogenic bacteria, and can be used as effective components to be applied to gingivitis resistance, dental plaque resistance and dental calculus resistance.
Meanwhile, isoliquiritigenin, liquiritin and isoliquiritin in the licoflavone also have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. The antibacterial/antimicrobial activity of isoliquiritigenin, liquiritin and isoliquiritin is attributed to the close relationship between phenolic hydroxyl and protein in the glycoside structure; the isoliquiritigenin, liquiritin and isoliquiritin are combined with proteins of pathogenic bacteria, so that the activity of the pathogenic bacteria is reduced and even lost, and the bacteriostatic effect is achieved.
Magnolol of officinalis is an effective component extracted from dried dry bark, root bark and branch bark of Magnolia officinalis or Magnolia obovata Thunb of Magnoliaceae, and has good pharmacological effects of resisting bacteria, resisting pathogenic microorganism, resisting inflammation, resisting ulcer, resisting oxidation, resisting tumor, inhibiting platelet aggregation, etc.
Magnolol in the toothpaste components has remarkable antibacterial activity on gram-positive bacteria, acid-resistant bacteria, yeast-like bacteria and filamentous fungi. Research shows that the minimum antibacterial concentration (MIC) test with streptomycin sulfate and amphotericin B as controls shows that the activity of magnolol against bacillus subtilis is higher than that of streptomycin sulfate; the activity of the anti-trichophyton mentagrophytes is higher than that of amphotericin B; the activity of the aspergillus niger resisting bacteria is the same as that of amphotericin B, the anti-dental caries effect of magnolol is very obvious, the minimum inhibitory concentration to dental caries bacteria is 6.3 mug/ml, and the antibacterial activity of magnolol is stronger than that of a typical antibacterial alkaloid berberine (MIC: 50 mug/ml).
Paeonol (Paeonol) is an effective component extracted from dried root bark of Paeonia suffruticosa Andr. The pharmacological effects of the compound have antibacterial, anti-inflammatory, antipyretic and anti-allergic effects, and the compound also has certain effects of relieving swelling and pain, resisting allergy, resisting oxidation, hypnotizing and reducing blood pressure. Paeonol also has analgesic effect, and can be used for preventing and treating oral ulcer. Researches find that magnolol and paeonol have the sterilization rate of more than or equal to 90 percent on escherichia coli and staphylococcus aureus, so that the magnolol and paeonol have strong bacterium inhibiting (killing) effects.
In the toothpaste matrix, calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, sodium dodecyl sulfate, sorbitol, polyethylene glycol-400, propylene glycol, hydroxyethyl cellulose, xanthan gum, essence and the like are included, and the proportion of the matrix components is optimized to be used as a carrier of licoflavone and glycyrrhizin, so that the traditional Chinese medicine components in the raw materials can be fully dissolved, the paste is fine, compact, bright and uniform in color distribution, and the quality of the paste is further improved.
As further description of the technical scheme of the invention, the essence is one or more of fruit essence, tea essence and drug essence. The essence can clean halitosis, and improve halitosis.
The invention also provides a preparation method of the toothpaste containing licoflavone, which comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
In the preparation method, the invention fully protects the effective antibacterial and bactericidal component in the licoflavone, which has obvious inhibiting and killing effects on pathogenic bacteria causing oral cavity.
The invention also provides the toothpaste containing licoflavone and application of the toothpaste containing licoflavone prepared by the preparation method of the toothpaste in preventing and treating oral inflammation.
Based on the technical scheme, the invention has the following technical effects:
(1) the toothpaste containing licoflavone provided by the invention takes licoflavone as a main drug, is added with glycyrrhizin, magnolol and paeonol, is supplemented with a toothpaste matrix, has definite active ingredients and action mechanism, has good antibacterial, anti-inflammatory and analgesic effects, and has strong pertinence to pathogenic bacteria and small inhibition effect on nonpathogenic resident bacteria, so that the self-healing capacity and the oral cavity repair capacity of oral tissues to injury are effectively improved.
(2) The toothpaste containing licoflavone can promote healing of oral inflammation wound surface, so it has good therapeutic effect on oral inflammation such as oral ulcer and gingival swelling and pain, and its formula is scientific and simple, raw material cost is low, and cost performance is high. Compared with the traditional medicinal toothpaste for treating oral ulcer, the toothpaste has the advantages of less side effect, higher safety and good antibacterial and anti-inflammatory effects and oral cavity cleaning effects.
(3) The preparation method of the toothpaste containing licoflavone provided by the invention can fully protect the effective antibacterial and bactericidal components of licoflavone, magnolol and paeonol, and ensure that the effective components in the toothpaste can play the role of inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating stomatitis. The preparation method has the advantages of low cost of raw materials, simple operation, no influence on the activity of the traditional Chinese medicine components, few process steps and contribution to industrial production.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Example 1
The toothpaste containing licoflavone comprises the following components in parts by weight: 45 parts of calcium hydrophosphate dihydrate, 3 parts of silicon dioxide hydrate, 2.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 5 parts of hydroxyethyl cellulose, 0.3 part of xanthan gum, 0.15 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 1 part of licoflavone, 0.5 part of glycyrrhizin, 0.1 part of magnolol, 0.1 part of paeonol, 0.5 part of peppermint oil, 0.6 part of essence, 1 part of 1% brilliant blue solution, 0.5 part of eugenol and 0.8 part of sodium monofluorophosphate.
The preparation method of the toothpaste containing licoflavone comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 2
The toothpaste containing licoflavone comprises the following components in parts by weight: 40 parts of calcium hydrophosphate dihydrate, 2 parts of silicon dioxide hydrate, 3 parts of sodium dodecyl sulfate, 8 parts of sorbitol, 5 parts of polyethylene glycol-4005 parts of propylene glycol, 4 parts of hydroxyethyl cellulose, 0.2 part of xanthan gum, 0.10 part of sodium benzoate, 0.15 part of sodium pyrotetraphosphate, 0.5 part of licoflavone, 0.2 part of glycyrrhizin, 0.05 part of magnolol, 0.055 part of paeonol, 0.3 part of peppermint oil, 0.6 part of essence, 1% brilliant blue solution 1 part, 0.4 part of eugenol and 0.7 part of sodium monofluorophosphate.
The preparation method of the toothpaste containing licoflavone comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 3
The toothpaste containing licoflavone comprises the following components in parts by weight: 50 parts of calcium hydrophosphate dihydrate, 4 parts of silicon dioxide hydrate, 5 parts of sodium dodecyl sulfate, 12 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of propylene glycol, 6 parts of hydroxyethyl cellulose, 1.5 parts of xanthan gum, 0.4 part of sodium benzoate, 0.30 part of sodium pyrotetraphosphate, 1.5 parts of licoflavone, 0.6 part of glycyrrhizin, 0.15 part of magnolol, 0.15 part of paeonol, 0.6 part of peppermint oil, 0.8 part of essence, 1 part of 1% brilliant blue solution, 0.6 part of eugenol and 0.9 part of sodium monofluorophosphate.
The preparation method of the toothpaste containing licoflavone comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 4
The toothpaste containing licoflavone comprises the following components in parts by weight: 43 parts of calcium hydrophosphate dihydrate, 2.5 parts of silicon dioxide hydrate, 3.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 4.8 parts of hydroxyethyl cellulose, 0.6 part of xanthan gum, 0.12 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 0.75 part of licoflavone, 0.25 part of glycyrrhizin, 0.09 part of magnolol, 0.09 part of paeonol, 0.4 part of peppermint oil, 0.7 part of essence, 1 part of 1% brilliant blue solution, 0.48 part of eugenol and 0.78 part of sodium monofluorophosphate.
The preparation method of the toothpaste containing licoflavone comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 5
The toothpaste containing licoflavone comprises the following components in parts by weight: 40 parts of calcium hydrophosphate dihydrate, 4 parts of silicon dioxide hydrate, 3 parts of sodium dodecyl sulfate, 12 parts of sorbitol, 5 parts of polyethylene glycol-4005 parts of propylene glycol, 0.4 part of hydroxyethyl cellulose, 0.4 part of xanthan gum, 0.10 part of sodium benzoate, 0.30 part of sodium pyrotetraphosphate, 0.5 part of licoflavone, 0.6 part of glycyrrhizin, 0.05 part of magnolol, 0.15 part of paeonol, 0.3 part of peppermint oil, 0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4 part of eugenol and 0.9 part of sodium monofluorophosphate.
The preparation method of the toothpaste containing licoflavone comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 6 effectiveness test
General data
Refer to the standard and scale of diagnosis of oral ulcer in "oral mucosa Pathology". Randomly extracting 100 patients with recurrent oral ulcer meeting the diagnosis standard, 46 men and 54 women; the age is 18-60 years old; 63 cases of mild recurrent oral ulceration among them; severe recurrent oral ulceration (periglandular oral ulceration) 37 cases. The treatment group is divided into 50 cases and a control group into 50 cases randomly, and the difference of the age, the sex composition ratio, the disease course and the like of the patients in the two groups has no significant meaning.
Method of treatment
The control group is sprayed with vitamin B2 and vitamin C2 times/d, and the mixture is sprayed on ulcer surface with double-material throat wind for 3 times/d, and the average 7d is 1 course of treatment. The treatment group applied the toothpaste prepared in example 1 of the present invention to the affected part 1 times in the morning, in the middle of the morning and at the evening on day 2 of the onset of the disease.
Criteria for evaluating therapeutic effects
The treatment effect evaluation trial standard-IN classification method of recurrent oral ulcer (RAU) passed by China medical society mucosis professional group 2001 was adopted.
Total effective rate = (number of effective cases + number of effective cases)/total number of cases × 100%.
Results
The results of the two groups of therapeutic effects are shown in Table 1.
TABLE 1 comparison of the therapeutic effects of the control and treatment groups (n, n%)
| Group of | Recovery method | Show effect | Is effective | Invalidation | The total effective rate% |
| Control group | 35 | 10 | 1 | 4 | 92 |
| Treatment group | 30 | 5 | 3 | 12 | 76 |
As can be seen from table 1, the effective rate of the patient using the licoflavone-containing toothpaste prepared in example 1 is 76%, and the effective rate of the patient using the vitamin B2, vitamin C2 and the composition of the dual-material houfeng powder is 92%, which indicates that the efficacy of the licoflavone-containing toothpaste of this example is close to the efficacy of the composition of the medicines in preventing and treating dental ulcer.
The toothpaste containing licoflavone provided in example 1 can promote healing of oral inflammation wound, and has good treatment effect on oral inflammation such as oral ulcer and gingival swelling and pain, but compared with a control group, the toothpaste containing licoflavone provided in this example has the advantages of scientific and simple formula, low raw material cost, more convenience in use, and high cost performance.
The foregoing is merely exemplary and illustrative of the structures of the present invention, which are described in some detail and detail, and are not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications are possible without departing from the inventive concept, and such obvious alternatives fall within the scope of the invention.
Claims (6)
1. The toothpaste containing licoflavone is characterized by comprising the following components in parts by weight: 40-50 parts of calcium hydrophosphate dihydrate, 2-4 parts of silicon dioxide hydrate, 3-5 parts of lauryl sodium sulfate, 8-12 parts of sorbitol, 5-10 parts of polyethylene glycol-4005, 4-6 parts of propylene glycol, 0.5-1.5 parts of hydroxyethyl cellulose, 0.2-0.4 part of xanthan gum, 0.10-0.20 part of sodium benzoate, 0.15-0.30 part of sodium pyrotetraphosphate, 0.5-1.5 parts of licoflavone, 0.2-0.6 part of glycyrrhizin, 0.05-0.15 part of magnolol, 0.05-0.15 part of paeonol, 0.3-0.6 part of peppermint oil, 0.6-0.8 part of essence, 1 part of 1% brilliant blue solution, 0.4-0.6 part of eugenol and 0.7-0.9 part of sodium monofluorophosphate.
2. The licoflavone-containing toothpaste according to claim 1, characterized by comprising the following components in parts by weight: 45 parts of calcium hydrophosphate dihydrate, 3 parts of silicon dioxide hydrate, 2.5 parts of sodium dodecyl sulfate, 10 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of propylene glycol, 5 parts of hydroxyethyl cellulose, 0.3 part of xanthan gum, 0.15 part of sodium benzoate, 0.25 part of sodium pyrotetraphosphate, 1 part of licoflavone, 0.5 part of glycyrrhizin, 0.1 part of magnolol, 0.1 part of paeonol, 0.5 part of peppermint oil, 0.6 part of essence, 1 part of 1% brilliant blue solution, 0.5 part of eugenol and 0.8 part of sodium monofluorophosphate.
3. The toothpaste containing licoflavone according to claim 1, wherein licoflavone is an active substance extracted from glycyrrhiza uralensis, which is a Chinese medicine, by various methods and solvents and contains flavonoid as a main ingredient.
4. The licoflavone-containing toothpaste according to claim 1, wherein the essence is one or more of fruit essence, tea essence and drug essence.
5. A method for preparing licoflavone-containing toothpaste according to claim 1, comprising the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and licoflavone into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
6. Use of a licoflavone-containing toothpaste according to any one of claims 1-4 for the prevention and treatment of oral inflammation.
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