CN106539727A - Sterilization tooth-caring toothpaste - Google Patents

Abstract

The invention discloses a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：12 parts of antibacterial, 20 50 parts of abrasivuss, 46 parts of vitamin, 0.2 0.6 parts of Ubidecarenone, 37 parts of Herba Menthae, and 6 10 parts of water；The sterilization tooth-caring toothpaste energy inhibiting bacteria and diminishing inflammation of the present invention, Qinghuo Jiedu, hemostasis, nutrition gingiva prevent gingival hemorrhage and gingival atrophy, clean tooth, dispel halitosiss, repair mucosa injury and oral ulcer.

Description

Sterilization tooth-caring toothpaste

Technical field

The present invention relates to a kind of toothpaste, more specifically, more particularly to a kind of sterilization tooth-caring toothpaste.

Background technology

As modern life rhythm is accelerated, take in nutritious, often cause that endogenous fire is excessively prosperous, the intestines and stomach has some setbacks, Jin Erzao Into halitosiss, the problem of red swelling of gingiva bleeding, and oral environment is to need most in human lives face daily, oral problem Whole body health all can be affected again, oral health is the important component part of whole body health, maintain and improve quality of life Key factor.Modern study proves that odontopathy can cause or increase the systemic diseases such as coronary heart disease, diabetes.Therefore, oral cavity is good for Health not only enables a person to fully chew, and enjoys delicious food, provides the nutrition of abundance for body；Oral health not only makes one ability to speak Clearly, the wish of oneself is expressed heartily, freely exchange with people；Also it is avoided that and reduces " virus infection " and coronary heart disease, glycosuria The generation of the diseases such as disease, gastropathy, neonate under-weight.Develop successively both at home and abroad numerous has maintenance health-care effect to oral health Toothpaste, but make a general survey of existing product, it is difficult to reach inhibiting bacteria and diminishing inflammation, Qinghuo Jiedu, hemostasis, nutrition gingiva prevent gingival hemorrhage And gingival atrophy, tooth is cleaned, halitosiss are dispelled, the effect of mucosa injury and oral ulcer is repaired.

The content of the invention

Present invention aims to above-mentioned the deficiencies in the prior art, there is provided a kind of sterilization tooth-caring toothpaste.

The technical scheme is that what is be achieved in that：

A kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：Antibacterial 1-2 parts, abrasivuss 20-50 parts, dimension life Plain 4-6 parts, Ubidecarenone 0.2-0.6 part, Herba Menthae 3-7 parts, and water 6-10 parts.

Preferably, the raw material also including following weight portion：Radix Angelicae Sinensis 1-5 parts.

Preferably, the raw material also including following weight portion：Rhizoma Chuanxiong 2-4 parts.

Preferably, the raw material also including following weight portion：Flos Lonicerae 1-3 parts.

Preferably, the raw material also including following weight portion：Radix Glycyrrhizae extract 1-5 parts.

Preferably, the raw material also including following weight portion：Xylitol 3-5 parts.

Preferably, the raw material also including following weight portion：Strontium fluoride 0.1-0.3 parts.

Preferably, the antibacterial is dodecyl dimethyl benzyl ammonium chloride, DDAC, hexadecane Base dimethyl amine is according to 3-5: 2-3: 0.1 ratio is mixed to get.

Preferably, the preferred hydrated silica of the abrasivuss.

Preferably, the vitamin includes vitamin B2 and vitamin C, and its weight ratio is 1: 1.

The extracting method of Radix Glycyrrhizae extract is：By selected licorice medicinal materials, impurity is removed, crushed, water extraction, concentrated solution is lived Property carbon decoloring after be condensed into the extractum that relative density is 1.10-1.30, i.e. Radix Glycyrrhizae extract.

Antibacterial, antibacterial can kill intraoral harmful levels of pathogens, build the oral environment of health；Antibacterial is 12 Zephiran, DDAC, the complex of cetyl dimethyl amine oxide, due to it Strong cation, can quickly find the virus of the pathogenic bacteria in anion, tightly wrap up, and force the material stream in its core Go out, be allowed to inactivate.So fast and effeciently can kill with escherichia coli, staphylococcus aureuses, representated by Candida albicans Pathogenic entero becteria, pyogenic baeceria, pathogenic funguses.Simultaneously because acid-base value is identical with human body skin mucosa, can protect beneficial Flora growth habitat；, not allergy non-stimulated to skin, mucosa.Prevention infection, eliminates halitosiss；Zinc citrate, molecular formula： Zn3 (C6H5O7) 22H2O, zinc ion can suppress the metabolism of absorption and blood chain bacterium of the mutans streptococcus to glucose, to control tooth bacterium Speckle.

Vitamin B2, vitamin B2 (chemical formula：376.37) C17H2ON4O6, formula weight are called riboflavin, participate in raw in vivo Thing is aoxidized and energy metabolism, relevant with the metabolism of carbohydrate, protein, nucleic acid and fat, can improve human body to protein Utilization rate, enhancing development safeguards the integrity of skin and cell membrane, with protection skin follicle mucosa and sebaceous gland Function, help prevents and eliminates in oral cavity, the inflammatory reaction of lip, tongue and skin, is referred to as oral cavity reproductive syndrome, routed to oral cavity Infectionss play good preventive effect.

Vitamin C, vitamin C (English：Vitamin C, also known as L-AA) be High Primates animal and other The biological essential nutrients of minority, can promote the growth of tooth and skeleton, prevent dental bed bleeding, and prevent vitamin C deficiency.

Ubidecarenone, Ubidecarenone (hydroxy decyl ubiquinone) is a kind of fat-soluble antioxidant, can human activin cell and cell The nutrition of energy, with raising body immunity, strengthens the functions such as antioxidation, slow down aging and enhancing human activity.Ubidecarenone Contribute to metabolism, accelerating wound healing, during oral ulcer, Ubidecarenone may also help in, and reduce pain Pain and inflammation.

Herba Menthae, Herba Menthae are one of Chinese conventional Chinese medicines, and it is pungent cool property sweating antipyretic medicine, controls influenza, headache, mesh Red, fever of the body, throat, dental bed such as swell and ache the disease, and external can control neuralgia, skin pruritus, erythra and eczema etc..Usually with Herba Menthae generation Tea, clear away heart-fire improving eyesight；Herba Menthae can not only be used for flavoring agent, can make spice again；Herba Menthae contains menthol, and the material fresh breath can have There are various property of medicine, stomachache, gall-bladder problem such as spasm can be alleviated, also with antisepsis and sterilization, diuresis, resolving sputum, stomach invigorating and aid digestion etc. Effect.Edible Herba Menthae can cause insomnia in a large number, but low dose of eating conduces to sleep.

Radix Angelicae Sinensis, sweet in the mouth are warm in nature, with enriching blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, all cards of main blood deficiency, menoxenia, Jing Close, dysmenorrhea, lump in the abdomen knot poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, intestines are dry and shit is difficult, weight, ulcer sores after bloody dysentery, fall and flutter Damage, and there is antibiotic effect.

Rhizoma Chuanxiong, the rhizome of samphire Rhizoma Chuanxiong, acrid in the mouth are warm in nature, can blood-activating and qi-promoting, treatment stagnation of QI and blood all pains card. Chest side of body, all pains of abdominal part of qi depression to blood stasis can be treated；The hypochondriac pain of stagnation of QI due to depression of the liver；The obstruction of qi in the chest and cardialgia of heart arteries and veins stasis blocking；Liver blood stasis, product Poly- mass in the abdomen, chest side of body shouting pain；Traumatic injury, pain caused by ecchymoma；Blood stasis is through closing, puerperal evil leakage not under, menoxenia, congealing cold with blood stasis are difficult Produce, retention of placenta；Rheumatic arthralgia can be treated with wind-expelling pain-stopping again, headache card, is the key medicine of the six channels headache, and excessive rising of liver-YANG is had a headache Key medicine.

Flos Lonicerae, Flos Lonicerae are cold in nature, sweet in the mouth, enter lung, the heart, stomach, have functions that heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat wind, Cure mainly the diseases such as disease under distension, warm disease heating, heat toxin large carbuncle and tumor.Which makees thirsty, hyperhidrosis unhappiness, intestinal for dizzy dizzy, xerostomia Inflammation, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitiss, acute mastitiss, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, The diseases such as parotitiss, suppurative tonsillitiss have certain curative effect.

Radix Glycyrrhizae, invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；Nourishing the lung to arrest cough；Eliminating fire and detoxication；Coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite；Leanness face It is yellow；Shortness of breath and palpitation；Stomachache loose stool；Four limbs contraction；Hysteria；Cough and asthma；Laryngopharynx swelling and pain；Ulcerative carbuncle swells and ache；Infantile carbuncle；And Medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, four limbs contraction, carbuncle Sore, alleviates drug toxicity, strong；Radix Glycyrrhizae extractum and preparation Jing after refining and process has good cough-relieving, eliminating the phlegm, work of relievining asthma With.

Xylitol, the anti-caries characteristic of the xylitol effect in all of sweeting agent preferably, is that xylitol can not be by first Produce cariogenic bacterial fermentation to utilize in oral cavity, suppress the generation of streptococcus growth and acid；Secondly, when xylitol is chewed, can promote Enter salivation, saliva is more can both to rinse oral cavity, the antibacterial in tooth, it is also possible to increase alkalescence at saliva and dental caries speckle Aminoacid and ammonia density, while slow down pH value in oral cavity declining, the acidic materials for injuring tooth are neutralized dilution, it is suppressed that antibacterial In the absorption of dental surface, so as to reduce the acid etching of tooth, prevent dental caries and reduce the generation of dental plaque, consolidate tooth.

Strontium fluoride, fluoride can reduce the dissolubility of tooth top layer enamel and promote enamel remineralization, in suppressing oral cavity The growth of cariogenic bacteria, suppression antibacterial produce acid, and appropriate fluoride is taken in during tooth development, cusp can be caused to justify blunt, ditch and split Shoal, anticaries, strontium fluoride can be used for toothpaste anti-caries additive.

The present invention includes that antibacterial, abrasivuss, vitamin, Ubidecarenone, Herba Menthae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Lonicerae, Radix Glycyrrhizae are extracted Thing, xylitol, strontium fluoride, wherein, Herba Menthae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Lonicerae are formed according to theory of Chinese medical science compatibility, are disappeared with antibacterial Inflammation, Qinghuo Jiedu, detumescence hemostasis, anti-inflammatory analgetic, effect of damp eliminating cold expelling sterilization；By the use of hydrated silica as abrasivuss, its point Minor structure is in spherical shape under the microscope, coefficient of friction when brushing teeth with tooth is preferably minimized, is greatly reduced to adamantine Abrasion, plays the protective effect for gently going stain to tooth；Addition antibacterial, kills intraoral harmful levels of pathogens, builds health Oral environment；Vitamin B2 and vitamin C can prevent dental bed bleeding with preventing canker sore；Addition Ubidecarenone contributes to generation Thank, accelerating wound healing, during oral ulcer, Ubidecarenone may also help in, and reduce pain and inflammation； Addition Radix Glycyrrhizae extract, with good cough-relieving, eliminating the phlegm, antiasthmatic effect；The sterilization tooth-caring toothpaste energy inhibiting bacteria and diminishing inflammation of the present invention, relieves inflammation or internal heat Removing toxic substances, hemostasis, nutrition gingiva prevent gingival hemorrhage and gingival atrophy, clean tooth, dispel halitosiss, repair mucosa injury And oral ulcer.

Specific embodiment

With reference to specific embodiment, the present invention is described in further detail, but does not constitute to any of the present invention Limit.

Embodiment 1

Present embodiments provide a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：1 part of antibacterial, hydration silicon 20 parts of stone, 4 parts of vitamin, 0.2 part of Ubidecarenone, 3 parts of Herba Menthae, 1 part of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiong, 1 part of Flos Lonicerae, Radix Glycyrrhizae extract 1 Part, 3 parts of xylitol, 0.1 part of strontium fluoride, and 6 parts of water, wherein, antibacterial is by dodecyl dimethyl benzyl ammonium chloride, didecyl Base alkyl dimethyl ammonium chloride, cetyl dimethyl amine oxide are mixed to get according to 3: 2: 0.1 ratios.

Present invention sterilization tooth-caring toothpaste can adopt the conventional method of this area to prepare completely, such as《Detergent compositions technique Handbook》(Xu Baocai etc. writes, Chemical Industry Press, chemistry and applied chemistry publishing centre, January in 2006 the 1st edition) the Toothpaste making process disclosed in 594-597 page is prepared.Specifically, the preparation method of the present embodiment sterilization tooth-caring toothpaste For：After above-mentioned raw materials component is weighed, dispersion, mixing in pre-dispersed kettle are opened cream kettle vacuum pump processed and suck above-mentioned liquid material, then Scraper, agitator and colloid mill are driven, colloid mill, agitator and scraper after 50 minutes, is closed successively, vacuum breaker obtains the tooth protection that sterilizes Toothpaste.

Obviously, the preparation method of toothpaste is prior art in the present invention, not special character, and the present invention's mainly changes Enter to be that the difference of formula.

Embodiment 2

Present embodiments provide a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：1.2 parts of antibacterial, hydration 28 parts of Silicon stone, 4.5 parts of vitamin, 0.3 part of Ubidecarenone, 4 parts of Herba Menthae, 2 parts of Radix Angelicae Sinensis, 2.5 parts of Rhizoma Chuanxiong, 1.5 parts of Flos Lonicerae, Radix Glycyrrhizae 2 parts of extract, 3.5 parts of xylitol, 0.15 part of strontium fluoride, and 7 parts of water, wherein, antibacterial is by dodecyl dimethyl benzyl Ammonium chloride, DDAC, cetyl dimethyl amine oxide are mixed to get according to 5: 3: 0.1 ratios.

Embodiment 3

Present embodiments provide a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：1.5 parts of antibacterial, hydration 35 parts of Silicon stone, 5 parts of vitamin, 0.4 part of Ubidecarenone, 5 parts of Herba Menthae, 3 parts of Radix Angelicae Sinensis, 3 parts of Rhizoma Chuanxiong, 2 parts of Flos Lonicerae, Radix Glycyrrhizae extract 3 parts, 4 parts of xylitol, 0.2 part of strontium fluoride, and 8 parts of water, wherein, antibacterial by dodecyl dimethyl benzyl ammonium chloride, two Decyl dimethyl ammonium chloride, cetyl dimethyl amine oxide are mixed to get according to 4: 2.5: 0.1 ratios.

Embodiment 4

Present embodiments provide a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：1.8 parts of antibacterial, hydration 40 parts of Silicon stone, 5.5 parts of vitamin, 0.5 part of Ubidecarenone, 6 parts of Herba Menthae, 4 parts of Radix Angelicae Sinensis, 3.5 parts of Rhizoma Chuanxiong, 2.5 parts of Flos Lonicerae, Radix Glycyrrhizae 4 parts of extract, 4.5 parts of xylitol, 0.25 part of strontium fluoride, and 9 parts of water, wherein, antibacterial is by dodecyl dimethyl benzyl Ammonium chloride, DDAC, cetyl dimethyl amine oxide are mixed to get according to 3.5: 2.8: 0.1 ratios.

Embodiment 5

Present embodiments provide a kind of sterilization tooth-caring toothpaste, including the raw material of following weight portion：2 parts of antibacterial, hydration silicon 50 parts of stone, 6 parts of vitamin, 0.6 part of Ubidecarenone, 7 parts of Herba Menthae, 5 parts of Radix Angelicae Sinensis, 4 parts of Rhizoma Chuanxiong, 3 parts of Flos Lonicerae, Radix Glycyrrhizae extract 1- 5 parts, xylitol 3-5 parts, strontium fluoride 0.1-0.3 parts, and water 6-10 parts, wherein, antibacterial is by dodecyl dimethyl benzyl Ammonium chloride, DDAC, cetyl dimethyl amine oxide are mixed to get according to 4.2: 2.2: 0.1 ratios.

Test case 1

48 adult men and women are divided into into 6 groups, using embodiment 1-5 toothpaste, daily sooner or later each brush once, to using front and even Continue and tested using the mottle index LSI after 3 months respectively, method of testing and scoring rule are permitted son referring to Shanghai Communications University The master thesis of unit《A kind of clinical efficacy evaluation study of novel whitening toothpaste》The 1.4.1 of page 5～6.

LSI scoring methods, concrete scoring rule are as follows：

0 point-exist without mottle；

1 point-mottle size less than facing 1/3；Degree is slight mottle (yellow or yellowish-brown)；

2 points-mottle size less than facing 2/3；Degree is moderate mottle (moderate brown)；

3 points-mottle size more than facing 2/3；Degree is severe mottle (dark-brown or black).

Statistics experimenter is calculated using front LSI meansigma methodss and uses March using front LSI values and using LSI values after March LSI meansigma methodss afterwards, then mottle index LSI rates of descent are calculated, the results are shown in Table 1.

Table 1：Mottle index LSI tests table

	Mottle index LSI rates of descent, %
		Embodiment 1	38.2
Embodiment 2	36.5
		Embodiment 3	33.8
Embodiment 4	27.6
		Embodiment 5	32.9

Mottle index LSI rates of descent (%)=[using front LSI meansigma methodss-using LSI meansigma methodss after March]/use front LSI Meansigma methodss × 100%.

As seen from the data in Table 1, after using embodiment 1-5 toothpaste 3 months, LSI values are decreased obviously, the toothpaste of the present invention With preferably cleaning tooth effect.

Test case 2

Take healthy white rabbit 20,2.0～2.5kg of body weight, male and female dual-purpose.With 3% pentobarbital sodium 30mg/kg ear edge Vein is slowly injected into, and after family's rabbit anesthesia, lies on the back and is fixed on operating-table, and abdominal part median incision is about 6～8cm, exposes and fixed Liver, cuts liver organization in leftlobe of liver with operating scissorss and is about 1cm, wide about 1cm, high about 1cm, and wound surface is in injection sample bleeding.Wipe After removing the blood for spraying, immediately in wound surface local spreading thing sample 1g to be tried, gauze is covered, and oppresses 1min, 1min with 200g counterweights After remove counterweight, observe haemostatic effect, with not bleeding as hemostasis.Such as still bleeding, then plus spreading continues pressurization after examination thing sample. Observe 1 time every 30s, record bleeding stopping period.Such as more than 3min still bleeding, then it is designated as failing hemostasis, bleeding stopping period is designated as ＞ 3min.Every time after sample test, residual tested material being washed away with 37 DEG C of normal saline, making wound surface bleeding again, re-test is next to be received Examination thing sample.Every rabbit carries out 4 liver local woanded surfaces and damages hemostasis test experiments, and each tested material sample presses Latin equation The drug of topical application, to reduce the impact that liver local woanded surface damages otch difference and medication order.Each tested material sample is amounted to and carries out 20 The hemostasis experiment of secondary rabbit liver local woanded surface bleeding due to trauma.Haemostatic effect is designated as score value F by scoring method (1O/T) reciprocal, 3min with On fail hemostasis, F is designated as 0 without score value, and matched group adopts toothpaste bare substrate sample, identical with experimental group toothpaste matrix, does not contain Any both effectiveness medicine, YUNNAN BAIYAO group, using YUNNAN BAIYAOFEN, Yunnan Paiyao Group Corp., Ltd's production.As a result see Table 2.

Table 2：Haemostatic effect tests table

	Bleeding stopping period (min)	Score score value (F)
			Toothpaste bare substrate group	＞ 3	0
YUNNAN BAIYAO group	1.9±0.2	5.3±0.5
			Embodiment 1	2.0±0.2	5.0±0.5
Embodiment 2	2.1±0.2	4.8±0.5
			Embodiment 3	2.3±0.2	4.3±0.5
Embodiment 4	2.4±0.2	4.2±0.5
			Embodiment 5	2.2±0.2	4.5±0.5

As seen from the data in Table 2, after using embodiment 1-5 toothpaste, score value is obviously improved, and compares with toothpaste bare substrate group There is significant difference, statistically meaningful, embodiment 1-5 toothpaste is compared with YUNNAN BAIYAO group, no obvious difference Property, significantly, the toothpaste of the present invention has obvious anastalsis to haemostatic effect.

The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto, Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its Inventive concept equivalent or change in addition, should all be included within the scope of the present invention.

Claims (10)

1. a kind of sterilization tooth-caring toothpaste, it is characterised in that including the raw material of following weight portion：Antibacterial 1-2 parts, abrasivuss 20- 50 parts, vitamin 4-6 parts, Ubidecarenone 0.2-0.6 part, Herba Menthae 3-7 parts, and water 6-10 parts.

2. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Radix Angelicae Sinensis 1-5 parts.

3. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Rhizoma Chuanxiong 2-4 parts.

4. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Flos Lonicerae 1-3 parts.

5. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Radix Glycyrrhizae extract 1-5 parts.

6. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Xylitol 3-5 parts.

7. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that also including the raw material of following weight portion： Strontium fluoride 0.1-0.3 parts.

8. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that the antibacterial includes dodecyl two Methyl-benzyl ammonium chloride, DDAC, cetyl dimethyl amine oxide are according to 3-5: the mixing of 2-3: 0.1 ratio Obtain.

9. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that the preferred hydrated silica of the abrasivuss.

10. a kind of sterilization tooth-caring toothpaste according to claim 1, it is characterised in that the vitamin includes vitamin B2 And vitamin C.