CN107951764A - A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth - Google Patents

A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth Download PDF

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Publication number
CN107951764A
CN107951764A CN201711120602.0A CN201711120602A CN107951764A CN 107951764 A CN107951764 A CN 107951764A CN 201711120602 A CN201711120602 A CN 201711120602A CN 107951764 A CN107951764 A CN 107951764A
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China
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extract
mouth
canker sore
mucous membrane
chinese medicinal
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葛华亭
李涛
陈洁华
黄树聪
柏玮
林椰
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Mingchen Health Products Co Ltd
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Mingchen Health Products Co Ltd
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Priority to CN201711120602.0A priority Critical patent/CN107951764A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses a kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth.By weight percentage, which is made of following raw material：0.1~5% phellodendron extract, 0.1~5% Red Psychotria Leaf extract, 0.1~5% Ramulus Et Folium Pithecellobii Lucidi extract, 0.1~5% sowthistle tasselflower herb extract, 0.05~0.3% borneol, 0.1~0.7% organic zinc, remaining is toothpaste matrix.The Chinese medicinal toothpaste has the function that clearing heat and detoxicating, swelling and pain relieving, removing necrosis, promoting granulation, astringing to arrest bleeding, can repair impaired mucous membrane of mouth and prevention canker sore.

Description

A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth
Technical field
The present invention relates to a kind of toothpaste, belongs to oral cavity cleaning and nursing product technical field, has more particularly to one kind pre- Anti- canker sore and the Chinese medicinal toothpaste for repairing mucous membrane of mouth effect.
Background technology
Canker sore is also known as " aphtha ", is a kind of disease that incidence is higher in mouth disease.Mucous membrane of mouth local trauma, Stress, food, medicine, malnutrition, hormonal readiness change and are deficient in vitamin (such as folic acid, vitamin B12) or micro- Secondary element (such as zinc, iron) can the accidental disease.Its main feature is that mucous membrane of mouth limitation ulcerative lesions, with the lip in oral cavity, cheek, soft The mucous membrane of palate or gums etc. is common, has the characteristics that periodicity, recurrent, self limiting.Age of onset is generally at 10~30 years old Between, women is more, can occur throughout the year, and canker sore has self limiting, general 10 days or so can be with self-healing.
Canker sore is largely related with personal fitness and habits and customs, as rhythm of life is accelerated, work Make pressure increasing, cause body immunity to decline, easily trigger canker sore.In order to reduce canker sore, should form good Habits and customs, pay attention to oral hygiene, avoid damage to mucous membrane of mouth, avoid maror and local excitation, keep happy, protect The sufficient sleep of card, avoids fatigue, pays attention to rule of life and nutritional balance, avoids inducing the bad of canker sore as far as possible Factor.
Oral cavity cleaning and nursing product plays an important roll for reducing canker sore, should usually select bristle soft Health-care tooth-brush soft, brush finish is round and smooth, coordinates the health Chinese herbal toothpaste with prevention canker sore to use, can be effectively clear Mucous membrane of mouth can be safeguarded and repaired again to clean mouth chamber, this is effective nursing intervention to reducing canker sore.
Clinically western medicine canker sore, more based on anti-inflammatory, although good effect, treatment time is short, antibiotics Antiphlogistic is larger to health toxic side effect, easily causes body immunity to decline, and can also destroy Oral health behaviours balance, make Into the recurrence of canker sore.And Chinese medicine treatment canker sore focuses on and repairs Oral health behaviours environment, although treatment time is grown, peace Quan Xinggao, toxic side effect is small, the features such as being not likely to produce tolerance, therefore deep is favored by many patients.
Toothpaste is as people's common oral cleaning and nursing product, it has also become a kind of daily necessities for safeguarding oral health. Consumer with canker sore, often selecting has effects that specific aim curative effect type toothpaste.There is prevention currently on the market The Chinese medicinal toothpaste of canker sore and reparation mucous membrane of mouth is actually rare, especially while containing Cortex Phellodendri, Red Psychotria Leaf, pithecellobium clypearia, sheep The Chinese medicine composition of hoof grass, there is prevention canker sore and the toothpaste for repairing mucous membrane of mouth not to occur also.Therefore a kind of work(is developed The Chinese medicinal toothpaste of the significant prevention canker sore of effect and reparation mucous membrane of mouth is extremely urgent.
The content of the invention
The object of the present invention is to provide a kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, root According to Cortex Phellodendri, Red Psychotria Leaf, pithecellobium clypearia, four taste Chinese medicine of sowthistle tasselflower herb drug effect principle, then compound effect accelerating agent, collaboration reaches heat-clearing solution Poison, swelling and pain relieving, removing necrosis, promoting granulation, astringing to arrest bleeding, have and repair impaired mucous membrane of mouth and prevention canker sore.
What the present invention was achieved through the following technical solutions：
A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, by weight percentage, comprising 0.4~20% active ingredient of Chinese herbs, accelerating agent the effect of 0.15~1.0%, 79~99.45% matrix components.The activity Component includes phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract；Effect accelerating agent includes Borneol and organic zinc；The matrix components include moisturizer, abrasive, thickener, surfactant, sweetener, preservative, perfume Essence and deionized water.
The Chinese medicinal toothpaste of the present invention, by weight percentage, the raw material components that the active ingredient of Chinese herbs includes：0.1~ 5% phellodendron extract, 0.1~5% Red Psychotria Leaf extract, 0.1~5% Ramulus Et Folium Pithecellobii Lucidi extract, 0.1~5% sheep hoof Careless extract.
Furthermore, the raw material components that effect accelerating agent component includes：0.05~0.3% borneol, 0.1~ 0.7% organic zinc.
Furthermore, the raw material components that the matrix components include：20~60% moisturizer, 15~45% friction Agent, 0.8~1.5% thickener, 1.8~3% surfactant, 0.1~0.3% sweetener, 0.1~0.3% it is anti- Rotten agent, 0.8~2% essence, deionized water are added to 100%.
Furthermore, the activity that the phellodendron extract refers to extract from the dry bark of rutaceae Cortex Phellodendri into Point, including extracting solution and extract powder, preferably additive amount is 0.5%~2%.
Furthermore, the Red Psychotria Leaf extract is extracted from the root, leaf of the section platymiscium Red Psychotria Leaf of Rubiaceae nine Active ingredient, including extracting solution or extract powder, preferably additive amount are 0.5%~2%.
Furthermore, the Ramulus Et Folium Pithecellobii Lucidi extract be extracted from the stem and branch with leaf of legume pithecellobium clypearia activity into Point, including extracting solution and extract powder, preferably additive amount is 0.5%~2%.
Furthermore, the sowthistle tasselflower herb extract is the active ingredient extracted from feverfew sowthistle tasselflower herb, including is carried Liquid and extract powder are taken, preferably additive amount is 0.5%~2%.
Furthermore, the phellodendron extract extraction process is：
Cortex Phellodendri is ground into about 40 mesh, when adding the ethanol heating and refluxing extraction 3 of 10 times of amounts small, extracts 3 times, merges extraction Liquid, then vacuum distillation recycling ethanol, is condensed into Chinese medical concrete, is dried under reduced pressure, crush to obtain phellodendron extract；
The Red Psychotria Leaf extract extraction process is：Red Psychotria Leaf is ground into about 40 mesh, adds the ethanol heating of 10 times of amounts When refluxing extraction 3 is small, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, decompression is dry It is dry, crush to obtain Red Psychotria Leaf extract；
The Ramulus Et Folium Pithecellobii Lucidi extract extraction process is：Pithecellobium clypearia is ground into about 40 mesh, adds the ethanol heating of 10 times of amounts When refluxing extraction 3 is small, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, decompression is dry It is dry, crush to obtain Ramulus Et Folium Pithecellobii Lucidi extract；
The sowthistle tasselflower herb extract extraction process is：Sowthistle tasselflower herb is ground into about 40 mesh, adds the ethanol heating of 10 times of amounts When refluxing extraction 3 is small, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, decompression is dry It is dry, crush to obtain phellodendron extract.
Furthermore, effect accelerating agent is two kinds of mixtures of borneol and organic zinc, and wherein organic zinc includes lemon Any one in sour zinc, zinc lactate, glucose saccharic acid zinc, the preferred additive amount 0.1%~0.2% of borneol, organic zinc preferably adds Amount 0.3%~0.5%.
Furthermore, the moisturizer is one or more mixing in sorbierite, glycerine, polyethylene glycol, propane diols Thing.
The abrasive is one or both of calcium carbonate, calcium monohydrogen phosphate, silica, aluminium hydroxide mixture.
The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, guar gum, carragheen.
The surfactant for sldium lauryl sulfate, sodium lauroyl sarcosine, one kind in cocoyl glycine betaine or A variety of mixtures.
The sweetener is one or both of saccharin sodium, acesulfame potassium mixture.
The preservative is one or both of sodium benzoate, parabens mixture.
Above-mentioned toothpaste can also include other additives, such as sodium pyrophosphate, fluoride, titanium dioxide.
The present invention, which has prevention canker sore and repairs the herbal function toothpaste of mucous membrane of mouth, to be had the following advantages and beneficial Effect：
1st, the present invention is theoretical according to Chinese medicine succession, and Cortex Phellodendri, Red Psychotria Leaf, pithecellobium clypearia, four taste Chinese medical extract of sowthistle tasselflower herb are answered With applied in toothpaste, the activity of single medicinal material had not only been played, but also four taste Chinese medicines is complemented each other, it is synergistic.With heat-clearing Removing toxic substances, cooling blood and hemostasis, the effect of scattered stasis detumescence, removing necrosis, promoting granulation, collectively promote the quick healing of oral ulcer surface, repair impaired Mucous membrane of mouth and prevention canker sore.
2nd, the present invention with the addition of effect accelerating agent borneol, organic zinc, preferably cooperate with the quick repairing ulcer of Chinese medicine composition Face, accelerates Wound healing.Borneol is the treatment widely used medicine of canker sore, has clearing away heat to and alleviating pain, antibacterial anti-inflammatory, anti-saprophytic The inflammation such as machine, exudation and tissue edema to tissue liquid has inhibitory action, and borneol also has Transdermal absorption effect, can promote The Transdermal absorption of Chinese medicine, improves the bioavilability of Chinese medicine；Zinc is the essential trace elements of the human body, and zinc-deficiency can make body immunity Decline, increase the risk of canker sore.Zinc has astriction, mucous membrane can be promoted to regenerate, repair tissue cell, accelerates ulcer The healing in face.
The toothpaste of the present invention equally contains the menthol with refrigerant effect, belongs to toothpaste essence system.Menthol has Awakening consciousness, wind-dispelling heat-dissipating, sterilizing effect, menthol have nerve endings suppression and paralysis effect, have town to ulcer surface Pain and antiinflammation, menthol, which equally has, promotes Transdermal absorption effect, can change skin epidermis lipid conformation, increase medicine Transdermal absorption ability.Borneol, zinc salt, menthol collaboration Chinese medicine composition complements one another and synergy, forms one and completely repaiies System the effect of mucous membrane of mouth again.
3rd, the present invention also has the health-care effect of prevention canker sore in addition to the clinical efficacy for repairing mucous membrane of mouth, With the double effects having conditions in both attack and defence.The traditional Chinese medical science thinks that canker sore is that internal heat is flourishing, rising up of the stomach-fire, flaring up of deficient fire fumigate in mouth and Morbidity.Cortex Phellodendri, Red Psychotria Leaf in Chinese medicine composition of the present invention, pithecellobium clypearia, sowthistle tasselflower herb are respectively provided with clearing heat and detoxicating, clearing heat and cooling blood and make With, oral cavity can be prevented and got angry, the risk that reduction canker sore occurs.Zinc salt can supplement Zn-ef ficiency needed by human, prevention Canker sore caused by zinc-deficiency.Menthol in borneol and essence has antibacterial bacteriostatic, and fresh breath, reduces bacterial plaque, prevent and subtract Light gingivitis, safeguards oral cleaning health, prevents mouth infection, reduce the generation of canker sore.
4th, the present invention is using toothpaste as pharmaceutical carrier, in terms of mucous membrane of mouth is repaired, has than simple Chinese medicine preparation certain Superiority, that is, clean oral cavity function.Harmful bacteria such as Streptococcus sanguis and helicobacter pylori in oral cavity also have with canker sore Substantial connection.Whole oral cavity can be cleaned by brushing teeth, and reduce bacteria levels, simple Chinese medicine preparation is without cleaning oral cavity function.
The present invention has effects that to prevent canker sore and repairs the Chinese medicinal toothpaste of mucous membrane of mouth, contained Chinese medicinal component and effect Accelerating agent can substantially reduce the harmful bacteria in oral cavity, preferably prevent the generation of canker sore and promote oral ulcer surface Healing, has good usability compared to Chinese medicine preparation.In terms of active matter bioavilability, consumer when cleaning oral cavity, Active ingredient is directly absorbed into blood circulation system by oral mucosa and sublingual vein, avoid liver first pass effect and Destruction of the degradation of gastrointestinal enzyme and acid to active matter, improves the degree of absorbing of active matter, can equally reach single The effect of pure Chinese medicinal preparation.
5th, prevent canker sore invention increases people and repair the approach of mucous membrane of mouth, be no longer limited to medicine, With regard to that can safeguard oral health while common oral cleaning-nursing, while the application field of traditional Chinese medicine is expanded, had very strong Practicality.
Embodiment
The present invention has effects that to prevent canker sore and repairs the Chinese medicinal toothpaste of mucous membrane of mouth, by weight percentage, wraps Containing 0.4~20% active ingredient of Chinese herbs, accelerating agent the effect of 0.15~1.0%, 79~99.45% matrix components.It is described Matrix components include moisturizer, abrasive, thickener, surfactant, sweetener, preservative, essence and deionized water.
The raw material components that the active ingredient of Chinese herbs includes：0.1~5% phellodendron extract, 0.1~5% Red Psychotria Leaf Extract, 0.1~5% Ramulus Et Folium Pithecellobii Lucidi extract, 0.1~5% sowthistle tasselflower herb extract.
The raw material components that effect accelerating agent component includes：0.05~0.3% borneol, 0.1~0.7% it is organic Zinc.
The prevention canker sore complements each other with component the effect of repairing mucous membrane of mouth, synergistic.On the one hand have Clearing heat and detoxicating, swelling and pain relieving, removing necrosis, promoting granulation, promote the healing of ulcer surface, on the other hand with clearing heat and detoxicating, can prevent oral cavity The generation of ulcer.
The mechanism of action of active component of the present invention is simply expressed as follows：
Cortex Phellodendri, is the bark of rutaceae Cortex Phellodendri, also known as cork tree, first cypress, bark of a cork tree wood, bark of a cork tree skin.Bitter, it is cold in nature, have clear Hot eliminating dampness, purging intense heat and detonicating, swelling and pain relieving and other effects.For steaming bone and consumptive fever, red eye, swell pain, aphthae, sore swollen toxin etc..It is modern Pharmacology shows that the main active of phellodendron extract is jamaicin, has antibacterial action.
Red Psychotria Leaf, root, the leaf of wood, also known as nine section wood, great Luo umbrellas, fiery cylinder tree, mountain machete, dark mountain are saved for madder wort nine Public, weapons wood.Bitter, it is cool in nature, there is clearing heat and detoxicating, dispelling wind and eliminating dampness, detumescence and drawing out poison, erosion prevention and muscle growing and other effects, belong to removing toxic substances and promoting tissue regeneration Medicine.For tonsillitis, sphagitis, treating rheumatic ostealgia, treating swelling and pain by traumatic injury, traumatic hemorrhage etc. are controlled in external application.Modern pharmacology shows, Red Psychotria Leaf Extract main active is autumnolide, tannin and steroid.
Pithecellobium clypearia, is legume pithecellobium clypearia stem and branch with leaf, also known as enclose absurd fantastic tree, heart tree, three not just, hair washing sets, lands Money etc..Bitter, puckery, cold nature, have clearing heat and detoxicating, cool blood detumescence, sore of drying, saprophytic removing and other effects, for above exhaling Inhale road infection, acpuei pharyngitis, acute tonsillitis etc..Modern pharmacology shows that pithecellobium clypearia main active is flavonoid glycoside, phenol Class.
Sowthistle tasselflower herb, be feverfew tassel flower herb, also known as tassel flower, leaf lower red, redback chrismashush root and leaf, red autumnal leaves grass, Chinese milk vetch, Azurite is red.Bitter, it is cool in nature, there is clearing heat and detoxicating, cooling blood and hemostasis, eliminating stasis to subdue swelling and other effects, for the infection of the upper respiratory tract, oral cavity is burst Ulcer etc..Modern pharmacology shows that sowthistle tasselflower herb mainly contains Quercetin, quercitrin, rutin and flavonoids, has bacteriostasis.
Borneol, naturally dragon is obtained for composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves through steam distillation and crystallization Brain, also there is chemical industry synthesis, and bitter is cool in nature.With clearing heat and detoxicating, detumescence and promoting granulation, promoting blood circulation and stopping pain, convergence sore face and other effects, use In red eye, swell pain, abscess of throat, toothache, aphthae, burst after do not hold back, be treat canker sore good medicine.
Organic zinc (including zinc citrate, zinc lactate, zinc gluconate), organic zinc is conducive to absorption of human body, and irritation It is small.Zinc is one kind more important in 14 kinds of trace elements needed by human, participate in a variety of enzymes of human body synthesis, to growth and development, Repair tissue cell, strengthen immunity and improve Growth of Intelligence in Children etc. and play an important roll, while there is astriction, can be with Promote mucous membrane regeneration and accelerate the healing of ulcer surface.
Feature Chinese medicine composition disclosed by the invention：Phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sheep hoof Careless extract and effect accelerating agent borneol and organic zinc, the composition toothpaste containing features above, to repair mucous membrane of mouth and Prevention canker sore has good applicability and clinical effectiveness, and the feature group compound is had no applied to success case in toothpaste Example, belongs to first Application in tooth paste product field, has certain novelty and creativeness.
Below by specific preferred embodiment, the present invention is further explained, but these preferred embodiments are used only in more detail Purposes of discussion, and be not applied to limit the present invention in any form, it will be understood by those skilled in the art that the present invention removes following implementation Exception, can also make other similar changes and obtain similar result without departing from present disclosure and scope.
Following characteristics Chinese medicine composition：Phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract Extraction process is：Cortex Phellodendri is ground into about 40 mesh, when adding the ethanol heating and refluxing extraction 3 of 10 times of amounts small, extracts 3 times, merges Extracting solution, then vacuum distillation recycling ethanol, is condensed into Chinese medical concrete, is dried under reduced pressure, crush to obtain phellodendron extract.In addition, mountain Great Yan extracts, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract extraction process are same as above.
Embodiment 1
A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, by weight percentage, comprising Following raw material components：
Manufacture craft is as follows：
1) stirring and dissolving in container A is added after weighing nipagin esters, borneol, essence；
2) deionized water is added in premix pot B, then adds saccharin sodium, acesulfame potassium, sodium pyrophosphate, Hamposyl L Sodium, zinc citrate, phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract, and stirring and dissolving is uniform；
3) polyethylene glycol-400, sorbierite are added in premix pot C；
4) calcium carbonate, silica, sodium carboxymethylcellulose, guar gum, sldium lauryl sulfate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can Go out cream.
Embodiment 2
A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, by weight percentage, comprising Following raw material components：
Manufacture craft is as follows：
1) stirring and dissolving in container A is added after weighing borneol, essence；
2) deionized water is added in premix pot B, then adds sodium benzoate, saccharin sodium, sodium pyrophosphate, coconut oleoyl amine third Base glycine betaine, zinc lactate, phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract, and stirring and dissolving Uniformly；
3) propane diols, glycerine, sorbierite are added in premix pot C；
4) calcium monohydrogen phosphate, silica, sodium carboxymethylcellulose, xanthans, sldium lauryl sulfate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can Go out cream.
Embodiment 3
A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, by weight percentage, comprising Following raw material components：
Manufacture craft is as follows：
1) stirring and dissolving in container A is added after weighing nipagin esters, borneol, essence；
2) deionized water is added in premix pot B, then add sodium fluoride, acesulfame potassium, sodium pyrophosphate, zinc gluconate, Phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract, and stirring and dissolving is uniform；
3) polyethylene glycol -600, sorbierite are added in premix pot C；
4) silica, sodium carboxymethylcellulose, carragheen, sldium lauryl sulfate, titanium dioxide are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can Go out cream.
Embodiment 4
A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, by weight percentage, comprising Following raw material components：
Manufacture craft is as follows：
1) stirring and dissolving in container A is added after weighing nipagin esters, borneol, essence；
2) deionized water is added in premix pot B, then adds saccharin sodium, sodium pyrophosphate, zinc citrate, Cortex Phellodendri extraction Thing, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sowthistle tasselflower herb extract, and stirring and dissolving is uniform；
3) polyethylene glycol -600, sorbierite are added in premix pot C；
4) aluminium hydroxide, silica, sodium carboxymethylcellulose, guar gum, sldium lauryl sulfate are added in meal mixer；
5) pot B will be premixed and premix the liquid material in pot C and suck Manufacturing medicine extract machine under vacuum conditions, scraper plate is then started and stir Mix, suck the powder in meal mixer, powder deaerates 30 minutes into complete rear opening homogeneous, homogeneous；
6) after vacuum outgas 30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, after the assay was approved can Go out cream.
It is the content of effete test embodiment part below.
1st, acute systemic toxicity (peroral route) part
Healthy ICR mouse 50, half male and half female, 18~20g of weight, being randomly divided into 5 groups, (1 group is control group, and 4 groups is not Same dosage group), every group 10.Distilled water is added to be made into 30% suspension the Chinese medicinal toothpaste of the embodiment of the present invention 2, it is maximum by mouse Capacity is allowed to be set, institute is followed successively by 18,14,10,6 (g.kg to dosage conversions into former amount of paste to clothes-1).In animal fasting (no Prohibit water) 18 it is small when after, at twice to clothes (interval half an hour) in 1 day, but be incorporated as dose calculating, control group is same to clothes Isodose distilled water.Gavage is to 4h, 24h, 48h, 72h after clothes, observation animal general state, toxicity performance and dead animal Number.
As a result：In the 72h observation periods, when giving mouse with maximum acceptable concentration and maximum allowable capacity (18g/kg.d), Not it was observed that dead mouse.Mouse appetite, activity, hair color, state of mind etc. and control group no significant difference, i.e., without acute complete Body toxic reaction, is classified according to Oral toxicity, LD50 (mg/kg)>5000 be actual innocuous substance, this experiment maximum dose is 18g/kg.d, is far longer than 5000mg/kg.d, therefore the Chinese medicinal toothpaste of the embodiment of the present invention 2 has security.
2nd, Dichlorodiphenyl Acetate causes cavy Oral ulcer model test portion
Healthy guinea pig 40, half male and half female, 300~350g of weight, adapts to 3 days in laboratory, respectively from cavy Face and cheek Under left side inserting needle to cheek mucous membrane, 10% acetic acid 0.05ml/ of injection only, causes Oral ulcer model.The the 2nd, 3 day after injection Observe and measure its canker sore area.
Ulcerated 40 cavys are randomly divided into 4 groups, every group 10, the 1st group is blank control group, and the 2nd group is height Dosage group, the 3rd group is middle dose group, and the 4th group is low dose group.And smeared after measuring ulcer area on day 3 by prescribed dose Chinese medicinal toothpaste of the present invention, high dose group are smeared 5 times daily, and middle dose group is smeared 3 times daily, and low dose group is smeared 2 times daily.Even It is continuous to smear 4 days, measure daily and record the change of ulcer area, the results are shown in Table 1.
Influence (X ± S) A/mm of the Chinese medicinal toothpaste of the present invention of table 1 to cavy canker sore2
Group Tu Qian 1d 2d 3d 4d
Blank control group 32.02±11.01 32.67±10.19 29.36±8.28 26.36±7.26 20.67±9.32
High dose group 32.54±11.02 18.47±6.94*** 16.51±7.24*** 13.01±7.57*** 9.36±7.81***
Middle dose group 31.77±12.50 24.90±9.53* 18.29±8.26** 14.26±7.34** 9.40±5.01***
Low dose group 33.01±10.07 25.01±6.48 17.61±7.80* 13.01±7.23* 12.29±8.24**
The * P ＜ 0.05 compared with blank control, * * P ＜ 0.01, * * * P ＜ 0.001.
By table 1 the result shows that, Chinese medicinal toothpaste high dose group, middle dose group, low dose group and blank control group of the invention Compare with significant difference, illustrate the present invention can be obviously reduced acetic acid caused by cavy canker sore area, promote ulcer surface more Close, repair impaired mucous membrane of mouth.
3rd, clinical test part
70 different degrees of canker sore patients, wherein 32 people of male, 38 people of women, age are chosen in this clinical test At 18~45 years old, test group and control group, every group of 35 people are randomly divided into.Test group uses the Chinese medicine tooth of the embodiment of the present invention 2 daily Cream is brushed teeth 3 times, it is early, middle and late it is each be once no less than 3 minutes every time, control group uses the blank tooth without inventive compound Cream, the same test group of application method, patient avoids the medicine with other treatment canker sore during experiment, avoids maror.
Evaluation criterion：
Recovery from illness：Healed completely with canker sore in Chinese medicinal toothpaste of the present invention 7 days, and no relapse in 6 months.
It is effective：Healed completely with canker sore in Chinese medicinal toothpaste of the present invention 7 days, and no relapse in 3 months.
Improve：Healed completely with canker sore in Chinese medicinal toothpaste of the present invention 7 days, and no relapse in 1 month.
It is invalid：Healing is had no with more than 7 days canker sore of Chinese medicinal toothpaste of the present invention.
Utility efficiency result statistics is shown in Table 2.
2 investigation result of table counts
Group Number Recovery from illness It is effective Improve It is invalid Efficient %
Test group 35 16 12 5 2 94%
Control group 35 1 2 6 26 26%
Experiment shows that Chinese medicinal toothpaste of the invention reaches 94% to canker sore total effective rate, generates unexpected Effect.During whole experiment, test group subject does not occur adverse reaction phenomenon, illustrates that the Chinese medicinal toothpaste of the present invention has and promotes The clinical effectiveness of canker sore healing and safe and applicable property, have reached expected purpose.For single medicinal material, Chinese traditional medicine composition Thing has superposition and syneryistic effect, this Chinese traditional medicine composition thinking exactly of the invention, and Chinese medicine and its vast essence of application Deep part.
Embodiment described above is the limited elaboration to the present invention, not makees limit in any form to the present invention System, under the conditions of the spirit and scope of the present invention are not departed from, the modification made to embodiment belongs to technical solution of the present invention In the range of.

Claims (9)

  1. A kind of 1. Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth, it is characterised in that：By dentifrice composition The gross weight meter of thing, the Chinese medicinal toothpaste include 0.4~20% active ingredient of Chinese herbs, accelerating agent the effect of 0.15~1.0%, 79.0~99.45% matrix components；The active ingredient includes phellodendron extract, Red Psychotria Leaf extract, Ramulus Et Folium Pithecellobii Lucidi extract, sheep Hoof grass extract；Effect accelerating agent includes borneol and organic zinc；The matrix components include moisturizer, abrasive, thickening Agent, surfactant, sweetener, preservative, essence and deionized water.
  2. 2. the Chinese medicinal toothpaste according to claim 1 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：By the gross weight meter of dentifrice composition, raw material components that the active ingredient of Chinese herbs includes：0.1~5% Cortex Phellodendri extraction Thing, 0.1~5% Red Psychotria Leaf extract, 0.1~5% Ramulus Et Folium Pithecellobii Lucidi extract, 0.1~5% sowthistle tasselflower herb extract.
  3. 3. the Chinese medicinal toothpaste according to claim 1 that there is prevention canker sore and repair mucous membrane of mouth, it is characterised in that： By the gross weight meter of dentifrice composition, raw material components that effect accelerating agent component includes：0.05~0.3% borneol, 0.1 ~0.7% organic zinc.
  4. 4. the Chinese medicinal toothpaste according to claim 1 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：By the gross weight meter of dentifrice composition, raw material components that the matrix components include：20~60% moisturizer, 15~ 45% abrasive, 0.8~1.5% thickener, 1.8~3% surfactant, 0.1~0.3% sweetener, 0.1~ 0.3% preservative, 0.8~2% essence, deionized water are added to 100%.
  5. 5. the Chinese medicinal toothpaste according to claim 2 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：
    The phellodendron extract refers to the active ingredient extracted from the dry bark of rutaceae Cortex Phellodendri, including extracting solution and Extract powder, preferably additive amount are 0.5%~2%；
    The Red Psychotria Leaf extract is the active ingredient extracted from the root, leaf of the section platymiscium Red Psychotria Leaf of Rubiaceae nine, including is carried Liquid or extract powder are taken, preferably additive amount is 0.5%~2%；
    The Ramulus Et Folium Pithecellobii Lucidi extract is the active ingredient extracted from the stem and branch with leaf of legume pithecellobium clypearia, including extracting solution and Extract powder, preferably additive amount are 0.5%~2%；
    The sowthistle tasselflower herb extract is the active ingredient extracted from feverfew sowthistle tasselflower herb, including extracting solution and extract powder End, preferably additive amount are 0.5%~2%.
  6. 6. the Chinese medicinal toothpaste according to claim 5 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：The phellodendron extract extraction process is：
    Cortex Phellodendri is ground into about 40 mesh, when adding the ethanol heating and refluxing extraction 3 of 10 times of amounts small, extracts 3 times, merges extracting solution, Then vacuum distillation recycling ethanol, is condensed into Chinese medical concrete, is dried under reduced pressure, crush to obtain phellodendron extract；
    The Red Psychotria Leaf extract extraction process is：Red Psychotria Leaf is ground into about 40 mesh, adds the ethanol of 10 times of amounts to be heated to reflux Extract 3 it is small when, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, be dried under reduced pressure, powder It is broken to obtain Red Psychotria Leaf extract；
    The Ramulus Et Folium Pithecellobii Lucidi extract extraction process is：Pithecellobium clypearia is ground into about 40 mesh, adds the ethanol of 10 times of amounts to be heated to reflux Extract 3 it is small when, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, be dried under reduced pressure, powder It is broken to obtain Ramulus Et Folium Pithecellobii Lucidi extract；
    The sowthistle tasselflower herb extract extraction process is：Sowthistle tasselflower herb is ground into about 40 mesh, adds the ethanol of 10 times of amounts to be heated to reflux Extract 3 it is small when, extract 3 times, merge extracting solution, then vacuum distillation recycling ethanol, be condensed into Chinese medical concrete, be dried under reduced pressure, powder It is broken to obtain phellodendron extract.
  7. 7. the Chinese medicinal toothpaste according to claim 3 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：Effect accelerating agent is two kinds of mixtures of borneol and organic zinc, and wherein organic zinc is zinc citrate, zinc lactate, glucose Any one in saccharic acid zinc, the preferred additive amount 0.1%~0.2% of borneol, the preferred additive amount 0.3%~0.5% of organic zinc.
  8. 8. the Chinese medicinal toothpaste according to claim 4 for having effects that to prevent canker sore and repair mucous membrane of mouth, its feature It is：
    The moisturizer is sorbierite, one or more mixtures in glycerine, polyethylene glycol, propane diols；
    The abrasive is one or both of calcium carbonate, calcium monohydrogen phosphate, silica, aluminium hydroxide mixture；
    The thickener is sodium carboxymethylcellulose, one or more mixtures in xanthans, guar gum, carragheen；
    The surfactant is sldium lauryl sulfate, the one or more in sodium lauroyl sarcosine, cocoyl glycine betaine Mixture；
    The sweetener is one or both of saccharin sodium, acesulfame potassium mixture；
    The preservative is one or both of sodium benzoate, parabens mixture.
  9. 9. according to the Chinese medicine according to any one of claims 1 to 8 for having effects that to prevent canker sore and repair mucous membrane of mouth Toothpaste, it is characterised in that：The toothpaste can also include other additives, and other additives are selected from sodium pyrophosphate, fluorination One or more in thing, titanium dioxide.
CN201711120602.0A 2017-11-14 2017-11-14 A kind of Chinese medicinal toothpaste for having effects that to prevent canker sore and repair mucous membrane of mouth Pending CN107951764A (en)

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