CN111888308A

CN111888308A - Toothpaste for preventing oral ulcer and accelerating oral mucosa repair and process

Info

Publication number: CN111888308A
Application number: CN202010774276.0A
Authority: CN
Inventors: 贾鹏云; 刘媛; 胡秀芝; 李良志; 苑晖敏
Original assignee: Shandong Huasu Health Care Products Co ltd; Beijing Hwellso Pharmaceutical Co ltd
Current assignee: Shandong Huasu Health Care Products Co ltd; Beijing Hwellso Pharmaceutical Co ltd
Priority date: 2020-08-04
Filing date: 2020-08-04
Publication date: 2020-11-06
Anticipated expiration: 2040-08-04
Also published as: CN111888308B

Abstract

The invention discloses toothpaste for preventing canker sore and accelerating oral mucosa repair and a process thereof, wherein the toothpaste comprises the following raw materials: sorbitol, polyethylene glycol-400, silicon dioxide, cetylpyridinium chloride, allantoin, acai berry extract, centella asiatica extract, Chondrus crispus, xanthan gum, cellulose gum, sodium lauryl sulfate, saccharin sodium, titanium dioxide, essence and water. The production process comprises the following steps: firstly, preparing mixed liquid A, B, C from the liquid phase part respectively, and then homogenizing and stirring the mixed liquid A, B, C in sequence to prepare a mixed solution D; and mixing the mixed solution D with the solid phase part, and vacuumizing to prepare the toothpaste body for preventing the oral ulcer and accelerating the repair of the oral mucosa. The toothpaste provided by the invention can prevent oral ulcer, shorten the repair time of oral mucosa and effectively avoid ulcer recurrence through reasonable formula matching and synergistic action of the components.

Description

Toothpaste for preventing oral ulcer and accelerating oral mucosa repair and process

Technical Field

The invention relates to toothpaste and a process, in particular to toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a process.

Background

The oral ulcer, also called as aphtha, belongs to common oral mucosa diseases in clinic, and occurs on the inner side of lips, tongue abdomen, buccal mucosa and other parts, so that the oral cavity of a patient can generate severe burning-like pain, the individual diet is influenced, and the life quality of the patient is reduced.

The pathogenesis of oral ulcer is mainly as follows: topical wound, malnutrition, vitamin deficiency, mental stress, etc. According to the severity of the disease, the disease is divided into light oral ulcer and heavy oral ulcer. The light oral ulcer is generally treated in a local mode, for example, the anti-inflammatory and bactericidal powder is directly sprayed on an affected part, but severe pain is difficult to accept by a patient during spraying. The severe oral cavity usually shows that the ulcer recurs frequently and the disease is severe or the ulcer is not healed for a long time. For this reason, the pathogenic cause needs to be found out by analyzing the etiology, and the systemic treatment and the local treatment are adopted for the synergistic treatment, and the systemic treatment is as follows: taking immunosuppressant, antiphlogistic, vitamin, etc., but the relapse is still difficult to control, and the efficacy is slow, which is easy to cause the stomach upset.

The toothpaste belongs to daily necessities of people, is economical and practical and simple to operate by preventing oral ulcer and accelerating oral mucosa repair by using the toothpaste, avoids the stimulation of medicaments to intestines and stomach and increases the compliance of patients.

At present, Chinese herbal medicine toothpaste for preventing and treating oral ulcer has the defects of large adding amount of active ingredient Chinese herbal medicine extracts (such as ovate leaf holly bark extract, wild chrysanthemum extract and scutellaria extract), poor mouthfeel, difficult control of paste stability, limitation of paste appearance to Chinese herbal medicine yellow-green appearance and poor effect of preventing and treating oral ulcer. The oral ulcer repairing toothpaste added with the sodium azulene sulfonate is acknowledged by the market at present to have quick effect and good effect on ulcer prevention and treatment, but the raw material azulene sulfonate is expensive, high in activity and high in requirement on the stability of the toothpaste formula, and the blue-violet powder of the sodium azulene sulfonate has large limitation on the appearance of the toothpaste body and is easy for appearance fatigue of consumers.

Disclosure of Invention

In order to solve the defects of the technology, the invention provides toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a process thereof.

In order to solve the technical problems, the invention adopts the technical scheme that: the toothpaste for preventing the oral ulcer and accelerating the repair of the oral mucosa comprises the following components in parts by weight:

furthermore, the toothpaste comprises the following components in parts by weight:

a preparation process of toothpaste for preventing oral ulcer and accelerating oral mucosa repair comprises the following steps:

preparing raw materials according to the weight part ratio;

step two, dissolving saccharin sodium, cetylpyridinium chloride, allantoin, acai berry extract and centella asiatica extract in water to obtain a mixed liquid A, dispersing titanium dioxide in sorbitol to obtain a mixed liquid B, dispersing carrageen crispa, xanthan gum and cellulose gum in polyethylene glycol-400 to obtain a mixed liquid C, sequentially adding the mixed liquid A, the mixed liquid B and the mixed liquid C into a stirring device, and homogenizing and stirring for 30 minutes to prepare a mixed solution D;

step three, adding silicon dioxide into the mixed solution D, homogenizing and stirring for 15 minutes to prepare uniform and fine paste, closing the homogenizing and stirring, adding sodium lauryl sulfate, continuing to stir uniformly, stirring and degassing for 10 minutes, adding essence, stirring and vacuumizing for 15 minutes to prepare the toothpaste for preventing the dental ulcer and accelerating the repair of the oral mucosa;

and step four, taking out the prepared paste, pumping the paste into a filling machine for filling, and obtaining the finished toothpaste product for preventing the oral ulcer and accelerating the repair of the oral mucosa.

The invention discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair, which effectively prevents oral ulcer and accelerates oral mucosa repair through reasonable preparation, interaction and enhanced effect of active substances. Meanwhile, the compound emulsion has good formula stability, can be compounded with other effects for desensitization, moth prevention and bacterial plaque inhibition, can be made into different appearances, increases the selectivity of consumers, and has good market prospect. The invention also discloses a preparation process of the toothpaste for preventing the dental ulcer and accelerating the repair of the oral mucosa, the preparation process is divided into two steps, and the liquid phase and the solid phase are respectively and uniformly mixed and then are mixed to prepare the toothpaste, so that uniform, fine and stable high-quality toothpaste can be obtained.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments.

The invention discloses toothpaste with functions of preventing oral ulcer and accelerating repair of oral mucosa, which is prepared from sorbitol, polyethylene glycol-400, silicon dioxide, sodium saccharin, cetylpyridinium chloride, allantoin, acai berry extract, centella asiatica extract, essence and the like. The raw materials specifically comprise the following components in parts by weight:

wherein, the sorbitol is also called as sorbitol and is used as a humectant, has good moisturizing performance, effectively keeps the moisture of the paste, maintains the fluidity of the paste and lowers the freezing point; the polyethylene glycol-400 is also used as a humectant, so that the moisturizing performance is further enhanced, the tooth stain can be effectively decomposed, the color spots are reduced, the synergistic effect with other components is realized, the whitening and stain removing effects are realized, the oral cavity can be kept in a safe and sanitary environment, and the effect of preventing and treating the oral ulcer is realized;

the silicon dioxide is an abrasive of the toothpaste, is used as a high-end abrasive, has stable property, does not damage teeth and gum, and has the effect of preventing and treating dental ulcer by the synergistic effect with other components; the cetylpyridinium chloride is a commonly used bactericide in the mouthwash, can effectively kill harmful bacteria in the oral cavity, and has the effect of preventing and treating the dental ulcer by the synergistic effect of other components; allantoin plays a role in promoting wound healing and accelerating the repair of oral mucosa;

the acai berry extract is rich in vitamins, anthocyanin and the like, has good anti-inflammatory and antioxidant effects, and improves the oral ulcer preventing effect and the wound healing promoting effect of the toothpaste; the centella asiatica extract has the function of clearing away heat, and has the synergistic effect with other components of the toothpaste, so that the effect of preventing dental ulcer and promoting wound healing of the toothpaste are further improved;

chondrus crispus, xanthan gum and cellulose gum are all commonly used thickening agents in toothpaste; sodium lauryl sulfate is an anionic surfactant and is used as a foaming agent in the toothpaste, and the emulsification of the sodium lauryl sulfate is helpful for oil-soluble substances such as essence and the like to be uniformly combined with other components in the toothpaste to form a stable system; the saccharin sodium is a common food additive and is used as a sweetening agent in the toothpaste to improve the use feeling; titanium dioxide is also a common food additive and plays a role in increasing the whiteness of the toothpaste; the essence adopts food-grade toothpaste essence, such as mint essence, so that the toothpaste is fresh and comfortable in use; the water is deionized water heated at 80 ℃, so that the toothpaste is clean and sterile, and the safety of the toothpaste components is improved.

Therefore, the toothpaste with the functions of preventing the oral ulcer and accelerating the repair of the oral mucosa, disclosed by the invention, can prevent the oral ulcer, shorten the repair time of the oral mucosa and effectively avoid the recurrence of the ulcer by reasonable formula collocation and synergistic action of all components. Compared with the prior art, the method has the following advantages:

1) the toothpaste for preventing oral ulcer and accelerating oral mucosa repair has no toxicity and no irritation to oral mucosa.

2) The toothpaste for preventing the oral ulcer and accelerating the repair of the oral mucosa has good effects of preventing and treating the oral ulcer by reasonably combining cetylpyridinium chloride, allantoin, acai berry extract and centella extract.

3) The cetylpyridinium chloride is added into the toothpaste disclosed by the invention to effectively kill oral harmful bacteria, the allantoin promotes wound healing, the acai berry extract (rich in vitamins and anthocyanin) is anti-inflammatory and antioxidant, the centella asiatica extract is heat-clearing and detoxifying, and the synergistic effect of the components enables the toothpaste provided by the invention to have the effects of preventing oral ulcer, shortening the repair time of oral mucosa and effectively avoiding relapse.

4) The toothpaste disclosed by the invention has good stability, can be compounded with other effects (desensitization, moth prevention and bacterial plaque inhibition), can also be made into various fragrant tastes, and provides more choices for users.

The invention also discloses a preparation process of the toothpaste for preventing oral ulcer and accelerating oral mucosa repair, which comprises the following steps:

preparing raw materials according to the weight part ratio;

Compared with the traditional one-step treatment, the treatment mode can ensure that all the components are mixed more fully, toothpaste with better uniformity, fineness and stability is obtained, and the product quality of the toothpaste is ensured.

The toothpaste for preventing oral ulcer and accelerating oral mucosa repair and the preparation process thereof disclosed by the present invention will be further described in detail with reference to the following specific examples.

[ EXAMPLES one ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 32 parts of sorbitol, 4 parts of polyethylene glycol-4004 parts of silicon dioxide, 0.05 part of cetylpyridinium chloride, 0.5 part of allantoin, 0.5 part of acai berry extract, 0.005 part of centella asiatica extract, 0.3 part of carrageen crispatus, 0.2 part of xanthan gum, 0.55 part of cellulose gum, 1.3 parts of sodium lauryl sulfate, 0.16 part of saccharin sodium, 0.1 part of titanium dioxide, 0.95 part of essence and 30 parts of water.

The preparation process specifically comprises the following steps:

step one, preparing raw materials according to the weight part ratio of the embodiment one;

Further, the toothpaste for preventing oral ulcer and accelerating oral mucosa repair obtained in the first embodiment is subjected to performance detection, and the detection process and the result are as follows:

1. detecting sensory and physicochemical indexes of the toothpaste;

1) sensory detection: taking 2 toothpaste samples, cutting tubes, visually detecting the toothpaste, and detecting the fragrance and the smell of the nose;

2) and (3) pH detection: weighing 1 toothpaste sample, weighing 5g toothpaste from the toothpaste sample to 0.01g, placing in 50mL beaker, adding 20mL distilled water, stirring, measuring with pH meter at 20 deg.C, and reading pH indication value within 10 min.

3) Detection of excessively hard particles: using a PH detection sample toothpaste, weighing 5g of toothpaste from the toothpaste on a scratch-free glass slide, putting the glass slide into a fixed groove of an excessively hard particle tester, pressing a friction copper block, starting a switch to enable the copper block to rub repeatedly for 100 times, stopping rubbing, removing the glass slide, cleaning the glass slide by water or hot nitric acid, and observing whether the scratch exists on the glass slide.

The various tests of the sensory and physicochemical indexes are carried out according to the above mode, and the specific test results are shown in table 1:

table 1 test results of sensory and physicochemical indexes of the same toothpaste as in example

As can be seen from the test results in Table 1, the toothpaste test results obtained in the first example all meet the national standards.

2. Detecting microbial indexes and toxic substance contents of the toothpaste;

1) the total number of colonies, mold and yeast, heat-resistant Escherichia coli and Pseudomonas aeruginosa were detected according to the regulations of the microorganism test method in chapter five of the technical Specification for cosmetic safety.

2) Measuring the content of lead (Pb); directly feeding a sample by using a graphite furnace atomic absorption spectrophotometer to determine the lead content; using a sample toothpaste for pH detection, weighing 2g of toothpaste from the sample toothpaste, placing the toothpaste in a 100mL beaker, adding 50mL of diluent and 1.0mL of nitric acid, and stirring on a magnetic stirrer for about 20min until the toothpaste becomes a uniform solution; simultaneously, a microsyringe is used for absorbing 10 mu L of sample solution, the sample solution is immediately injected into a graphite tube, a graphite furnace switch is started for determination, and an absorption value is recorded; and simultaneously, blank experiments are carried out.

Preparing 3-5 lead standard solutions with corresponding concentrations according to the absorption values of the samples, measuring the absorption values of the lead standard solutions, and subtracting a blank value to prepare a concentration-absorption value curve. Subtracting the blank absorption value from the sample absorption value, checking a standard curve to obtain the corresponding concentration, and multiplying the corresponding concentration by the dilution factor to obtain the lead content in the sample toothpaste.

The lead content (W) is calculated as formula 3:

w ═ k ═ c formula 3

Wherein W represents the lead content in the sample, k represents the dilution factor of the sample, and c represents the corresponding concentration found on the standard curve, and the unit is mg/kg.

3) And (3) measuring the arsenic content: according to the arsenic spot regulation in the national standard GB 7917.2.

The microorganism indexes and the content of the toxic substances are detected according to the mode, and the specific detection results are shown in table 2:

TABLE 2 detection results of microorganisms and toxic substances of the same toothpaste as the example

As can be seen from the test results in Table 2, the test results of the toothpaste obtained in the first example in terms of hygiene are all in accordance with and better than the national standards.

Note: the toothpaste sensory, physicochemical index detection, microbial index detection and toxic substance content detection are carried out by the middle-detection Korea corporation for the detection of Tianjin, so that the detection results are directly shown.

3. Animal experiment for testing oral ulcer

By establishing an animal model of oral ulcer of the rabbit, the influence of the toothpaste of the embodiment on the oral ulcer of the rabbit is observed, the prevention and treatment effect of the toothpaste on the oral ulcer of the rabbit is verified, and a theoretical basis is provided for clinical prevention and treatment of the oral ulcer of a human body.

The experimental animals adopt Japanese big ear white breed rabbits with the common grade, the weight is 2-3 kg, and 6 animals are male. Animal feeding management conditions: the temperature is 20-26 ℃, the relative humidity is 40-70 parts, and the illumination is 12h and the light and the shade are alternated. Drinking water freely, feeding the feed in standard blocks to maintain the feed, and purchasing the commercially qualified product from the animal feed.

The test process specifically comprises the following steps:

1) establishing an oral ulcer animal model by a chemical burning method:

taking an adult healthy rabbit, vertically fixing the adult healthy rabbit on the oral mucosa surface of the rabbit by using a glass tube with the inner diameter of 0.6cm and the length of 3cm, injecting 0.2mL of glacial acetic acid with the volume fraction of 50 parts into the glass tube, and dipping the glacial acetic acid by using a cotton swab after 30 s. After 24h, the area of the mucosal ulcer is measured by a digital caliper, the inflammatory hyperemia is observed, and the success of modeling is confirmed.

2) After successful modeling, experimental grouping was performed with two rabbits per group:

blank group: the ulcer part is not treated;

control group: applying control toothpaste containing 0.1 part of sodium guaiazulene sulfonate to ulcer part, and can be used for preventing and treating oral ulcer;

experiment group one: the toothpaste obtained in the first embodiment was applied to the ulcer.

3) The treatment process comprises the following steps: the success of the modeling was day 0, 260g of feed was given every morning from day 0 and the food intake was calculated the next day remaining. The ointment is smeared on the affected part of the oral ulcer of the rabbit as a uniform thin layer by using a medical cotton swab, and the smearing amount is confirmed to be about 0.05-0.1 g according to the size of the ulcer so as to ensure that the affected part is smeared uniformly. One side is coated before eating in the morning, in the middle and at night every day, and the meal is eaten after 30 minutes. Observations were recorded daily for rabbits: body weight, feeding, ulcer diameter measurement. The experimental results are shown in tables 3 to 5.

TABLE 3 example daily feeding conditions (g) for a rabbit

TABLE 4 example weight condition (Kg) of rabbit

TABLE 5 example rabbit ulcer diameter (mm)

4) And (4) analyzing results: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the curative effect of the experimental group I is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, only one ulcer in the experimental group had a diameter that decreased to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the experimental group I and the toothpaste of the control group have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer from the variation data of the ulcer surface, but the healing effect of the experimental group I is better than that of the control group, which shows that the toothpaste obtained in the embodiment I has good effects of preventing the oral ulcer and repairing the oral mucosa.

4. Trial use of toothpaste

The toothpaste of the embodiment is tried on 10 common people, wherein 5 men and 5 women are aged 20-40 years. The subjects involved had varying degrees of oral ulceration. After the toothpaste of the embodiment is tried, the problem of dental ulcer is improved after the toothpaste is used for two weeks continuously once in the morning and at night.

[ example two ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 33 parts of sorbitol, 3 parts of polyethylene glycol-4003 parts of silicon dioxide, 24 parts of silicon dioxide, 0.04 part of cetylpyridinium chloride, 0.7 part of allantoin, 0.7 part of acai berry extract, 0.002 part of centella asiatica extract, 0.35 part of carrageen crispus, 0.25 part of xanthan gum, 0.6 part of cellulose gum, 1.5 parts of sodium lauryl sulfate, 0.15 part of saccharin sodium, 0.15 part of titanium dioxide, 1.0 part of essence and 33 parts of water.

The preparation process disclosed in this example is the same as that of the first example except for the different weight parts of the raw materials.

Further, the toothpaste obtained in example two for preventing oral ulcer and accelerating oral mucosa repair was subjected to performance tests, including sensory, physicochemical indices, microorganisms and toxic substance test items of the toothpaste, the test procedure was the same as that of example one, and the test results are shown in tables 6 and 7:

table 6 sensory, physicochemical index test results of the second sample toothpaste of example 6

As can be seen from the test results in Table 6, the toothpaste test results obtained in example two all meet the national standards.

TABLE 7 detection results of microorganisms and toxic substances of toothpaste samples II of example

As can be seen from the test results in Table 7, the test results of the third example of toothpaste are all in accordance with and better than the national standards.

For animal experiments, the experimental process is the same as that of the first embodiment, the blank group and the control group are also the same as that of the first embodiment, the group treated by the toothpaste of the second embodiment is taken as an experimental group two, the experimental group two adopts two rabbits which are the same as that of the first embodiment, and the experimental results of the weight, the eating condition and the ulcer diameter are shown in tables 8-10 when the experimental group two and the experimental group one are simultaneously treated:

TABLE 8 example daily feeding conditions (g) of two rabbits

TABLE 9 weight (Kg) of two rabbits of the examples

TABLE 10 example two rabbit ulcer diameter (mm)

According to the experimental data of tables 8-10, result analysis is carried out: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the curative effect of the experimental group II is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group II is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, the diameter of the experimental group two ulcers narrowed to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the experimental group two and the toothpaste of the control group both have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer according to the change data of the ulcer surface, but the healing effect of the experimental group two is better than that of the control group, which shows that the toothpaste obtained in the example two has good effects of preventing the oral ulcer and repairing the oral mucosa.

Similarly, the toothpaste trial test is also performed in this embodiment: the toothpaste of the embodiment is tried on 10 common people, wherein 5 men and 5 women are aged 20-40 years. The subjects involved had varying degrees of oral ulceration. After the toothpaste of the embodiment is tried, the problem of dental ulcer is improved after the toothpaste is used for two weeks continuously once in the morning and at night.

[ EXAMPLE III ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 34 parts of sorbitol, 5 parts of polyethylene glycol-4005 parts of silicon dioxide, 0.03 part of cetylpyridinium chloride, 0.8 part of allantoin, 1 part of acai berry extract, 0.001 part of centella asiatica extract, 0.4 part of carrageen crispus, 0.2 part of xanthan gum, 0.5 part of cellulose gum, 1.4 parts of sodium lauryl sulfate, 0.18 part of saccharin sodium, 0.16 part of titanium dioxide, 0.9 part of essence and 32 parts of water.

Further, the toothpaste for preventing oral ulcer and accelerating oral mucosa repair obtained in the third example was subjected to performance tests, including sensory, physicochemical indexes, microorganisms and toxic substance test items of the toothpaste, the test process was the same as that of the first example, and the test results are shown in tables 11 and 12:

TABLE 11 results of sensory and physicochemical index tests of three toothpaste samples

As can be seen from the test results in Table 11, the toothpaste test results obtained in the third example all meet the national standards.

TABLE 12 results of detection of microorganisms and toxic substances in the three samples of toothpaste of example

As can be seen from the test results in table 12, the test results in hygiene of the toothpaste obtained in example three all meet and are superior to the national standards.

For animal experiments, the experimental process is the same as that of the first embodiment, the blank group and the control group are also the same as that of the first embodiment, the group treated by the toothpaste in the third embodiment is taken as the third experiment group, the third experiment group adopts two rabbits which are the same as those in the first embodiment, and the experiment results of the weight, the eating condition and the ulcer diameter are shown in tables 13-15 when the third experiment group and the first experiment group are simultaneously treated:

TABLE 13 example three rabbits daily food intake (g)

TABLE 14 weight (Kg) of three rabbits in example

TABLE 15 example three rabbit ulcer diameter (mm)

According to the experimental data of tables 12-15, result analysis is carried out: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the curative effect of the experimental group III is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group III is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, the diameter of the three ulcers in the experimental group decreased to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the third experimental group and the toothpaste of the control group have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer from the data of the change of the ulcer surface, but the healing effect of the third experimental group is better than that of the control group, which shows that the toothpaste obtained in the third embodiment has good effects of preventing the oral ulcer and repairing the oral mucosa.

[ EXAMPLE IV ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 35 parts of sorbitol, 7 parts of polyethylene glycol-4007 parts of silicon dioxide, 22.5 parts of silicon dioxide, 0.07 part of cetylpyridinium chloride, 1 part of allantoin, 1.5 parts of acai berry extract, 0.008 part of centella asiatica extract, 0.2 part of carrageen crispus, 0.15 part of xanthan gum, 0.65 part of cellulose gum, 1.55 parts of sodium lauryl sulfate, 0.2 part of saccharin sodium, 0.2 part of titanium dioxide, 1.05 parts of essence and 35 parts of water.

Further, the toothpaste obtained in the fourth example for preventing oral ulcer and accelerating oral mucosa repair was subjected to performance tests, including items of sensory, physicochemical indexes, microorganisms and toxic substance tests, the test procedures were the same as those of the first example, and the test results are shown in tables 16 and 17:

TABLE 16 sensory, physicochemical index test results of the four samples of toothpaste of the example

As can be seen from the test results in table 16, the toothpaste test results obtained in the fourth example all meet the national standards.

TABLE 17 results of detection of microorganisms and toxic substances in four samples of toothpaste of example

As can be seen from the test results in table 17, the test results in hygiene of the toothpaste obtained in example four all meet and are superior to the national standards.

For animal experiments, the experimental process is the same as that of the first embodiment, the blank group and the control group are also the same as that of the first embodiment, the group treated by toothpaste in the fourth embodiment is the fourth experiment group, the fourth experiment group adopts two rabbits which are the same as that in the first embodiment, and the experiment results of the weight, the eating condition and the ulcer diameter are shown in tables 18-20 when the fourth experiment group and the first experiment group are simultaneously treated:

TABLE 18 example four rabbits daily feeding (g)

TABLE 19 example four body weight conditions (Kg)

TABLE 20 example four rabbit ulcer diameter (mm)

According to the experimental data of tables 17-20, result analysis is carried out: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the curative effect of the experimental group IV is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group four is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, the diameter of the four ulcers in the experimental group decreased to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the experimental group four and the toothpaste of the control group have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer from the data of the change of the ulcer surface, but the healing effect of the experimental group four is better than that of the control group, which shows that the toothpaste obtained in the example four has good effects of preventing the oral ulcer and repairing the oral mucosa.

[ EXAMPLE V ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 36 parts of sorbitol, 6 parts of polyethylene glycol-4006 parts of silicon dioxide, 26.5 parts of silicon dioxide, 0.08 part of cetylpyridinium chloride, 0.9 part of allantoin, 1.7 parts of acai berry extract, 0.001 part of centella asiatica extract, 0.25 part of carrageen crispus, 0.3 part of xanthan gum, 0.7 part of cellulose, 1.2 parts of sodium lauryl sulfate, 0.17 part of saccharin sodium, 0.17 part of titanium dioxide, 1.1 part of essence and 34 parts of water.

Further, the toothpaste obtained in the fifth embodiment for preventing oral ulcer and accelerating oral mucosa repair was subjected to performance tests, including items of sensory, physicochemical indexes, microorganisms and toxic substance tests, the test procedures were the same as those of the first embodiment, and the test results are shown in tables 21 and 22:

TABLE 21 results of sensory and physicochemical index tests of five toothpaste samples

As can be seen from the test results in Table 21, the toothpaste test results obtained in the fifth example all meet the national standards.

TABLE 22 results of microbiological and toxic substance testing of five samples of toothpaste

As can be seen from the test results in Table 21, the test results of the toothpaste obtained in the fifth example all meet and are superior to the national standards.

For animal experiments, the experimental process is the same as that of the first embodiment, the blank group and the control group are also the same as that of the first embodiment, the group treated by the toothpaste in the fourth embodiment is taken as an experimental group five, the experimental group five adopts two rabbits which are the same as those in the first embodiment, and the experimental results of the weight, the eating condition and the ulcer diameter are shown in tables 23-25, wherein the experimental group five and the experimental group one are simultaneously subjected to experimental treatment:

TABLE 23 example five rabbits are fed daily (g)

TABLE 24 weight (Kg) of five rabbits in the example

According to the experimental data of tables 23-25, result analysis was performed: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the curative effect of the experimental group five is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group five is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, the diameter of the five ulcers in the experimental group decreased to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the experimental group five and the toothpaste of the control group have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer from the variation data of the ulcer surface, but the healing effect of the experimental group five is better than that of the control group, and the toothpaste obtained in the embodiment five has the good effects of preventing the oral ulcer and repairing the oral mucosa.

[ EXAMPLE six ]

The embodiment discloses toothpaste for preventing oral ulcer and accelerating oral mucosa repair and a preparation process thereof, and the toothpaste comprises the following components in parts by weight: 34.5 parts of sorbitol, 4005.5 parts of polyethylene glycol-silicon dioxide, 23.5 parts of silicon dioxide, 0.1 part of cetylpyridinium chloride, 0.6 part of allantoin, 2 parts of acai berry extract, 0.004 part of centella asiatica extract, 0.28 part of carrageen crispus, 0.1 part of xanthan gum, 0.58 part of cellulose gum, 1.6 parts of sodium lauryl sulfate, 0.19 part of saccharin sodium, 0.18 part of titanium dioxide, 0.98 part of essence and 36 parts of water.

Further, the toothpaste obtained in the sixth embodiment for preventing oral ulcer and accelerating oral mucosa repair was subjected to performance tests, including items of sensory, physicochemical indexes, microorganisms and toxic substance tests of the toothpaste, the test procedures were the same as those of the first embodiment, and the test results are shown in tables 26 and 27:

TABLE 26 results of sensory and physicochemical index tests of six toothpaste samples

As can be seen from the test results in Table 26, the toothpaste test results obtained in the fifth example all meet the national standards.

TABLE 27 results of detection of microorganisms and toxic substances in six samples of toothpaste of example

As can be seen from the test results in Table 27, the test results of the toothpaste obtained in the fifth example all meet and are superior to the national standards.

For animal experiments, the experimental process is the same as that of the first embodiment, the blank group and the control group are also the same as that of the first embodiment, the group treated by the toothpaste in the fourth embodiment is taken as an experimental group five, the experimental group five adopts two rabbits which are the same as that in the first embodiment, and the experimental results of the weight, the eating condition and the ulcer diameter are shown in tables 28-30, wherein the experimental group five and the experimental group one are simultaneously subjected to experimental treatment:

TABLE 28 example six rabbits daily feeding conditions (g)

TABLE 29 weight conditions (Kg) of six rabbits of the example

TABLE 30 example six rabbits ulcer diameter (mm)

According to the experimental data of tables 28-30, result analysis is performed: in the treatment period of 7 days, except for the blank group, the ulcers of all animals in the control group and the experimental group are completely recovered, and the treatment effect of the experimental group six is better than that of the control group in the treatment period.

Body weight and food intake reflect ulcer healing: the food intake and the body weight are slightly increased along with the healing of the ulcer surface 3 days before the treatment, and the increase trend of the experimental group six is more obvious than that of the blank group and the control group. In the later period, with the recovery of the ulcer surface, the ingestion and the weight gain of each group tend to be stable.

Change in ulcer diameter size: on day 3 of treatment, the diameter of the six ulcers in the experimental group decreased to 1/2 and below on day 0.

Therefore, although the oral ulcer tends to be self-healed, the toothpaste of the experimental group six and the toothpaste of the control group have the effects of promoting the healing of the ulcer and shortening the healing time of the ulcer from the variation data of the ulcer surface, but the healing effect of the experimental group six is better than that of the control group, and the toothpaste obtained in the embodiment six has the good effects of preventing the oral ulcer and repairing the oral mucosa.

The above embodiments are not intended to limit the present invention, and the present invention is not limited to the above examples, and those skilled in the art may make variations, modifications, additions or substitutions within the technical scope of the present invention.

Claims

1. A toothpaste for preventing oral ulcer and accelerating oral mucosa repair is characterized in that: the raw materials comprise the following components in parts by weight:

2. the toothpaste for preventing canker sores and accelerating oral mucosal repair according to claim 1, wherein: the toothpaste comprises the following raw materials in parts by weight:

3. a process for preparing a toothpaste according to any one of claims 1-2 for preventing canker sores and accelerating oral mucosal repair, wherein: the preparation process comprises the following steps:

preparing raw materials according to the weight part ratio;