CN107441014A - A kind of evening clothing toothpaste of American-cockroach-extract-containing and preparation method thereof - Google Patents
A kind of evening clothing toothpaste of American-cockroach-extract-containing and preparation method thereof Download PDFInfo
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- CN107441014A CN107441014A CN201710603249.5A CN201710603249A CN107441014A CN 107441014 A CN107441014 A CN 107441014A CN 201710603249 A CN201710603249 A CN 201710603249A CN 107441014 A CN107441014 A CN 107441014A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention discloses evening clothing toothpaste of a kind of American-cockroach-extract-containing and preparation method thereof, includes the raw material of following mass fraction：Calcium monohydrogen phosphate 40.0~55.0%, D-sorbite 20.0~35.0%, glue 1.0~2.0%, sweetener 0~2.0%, foaming agent 2.0~4.0%, KF88 0.02%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate 0.4%, American-cockroach-extract 1.0~4.0%, essence 0~0.3%, deionized water are surplus.Add a certain amount of American-cockroach-extract, Paeonol extract honokiol extract in the basic components of toothpaste, manufactured toothpaste have it is antibacterial, go stain, pre- anti-caries, repair the effect of canker sore, firm tooth.
Description
Technical field
The present invention relates to oral cleaning nursing article technical field, it is related to a kind of evening clothing toothpaste of American-cockroach-extract-containing
And preparation method thereof.
Background technology
Daytime normal oral cavity activity, salivary secretion amount is more, reduces the accumulation of bacterium and swill in oral cavity；And oxygen
Gas concentration is high, and pH value is normal, and anaerobic bacteria is in holddown.And salivary secretion amount is reduced in night oral cavity, oral cavity it is self-cleaning
Act on low；Oxygen concentration relative reduction, anaerobic bacteria is able to amount reproduction, and anoxic causes the amount of blood supply of periodontium to reduce,
Oxygen supply deficiency is caused, is accumulated beneficial to noxious material, so as to cause under the defence capability of periodontal, antibacterial ability and repair ability
Drop；PH value is reduced, and advantage is provided for the growth of bacterial plaque, and bacterial plaque mainly causes larger harm to tooth and gum,
The generation of common dental caries and periodontosis will be caused again.In addition some customs that people form in daily life as inhaled for a long time
Cigarette, have tea, drink coffee, eating of the deeper food of color so that bacterial plaque and the swill for being attached to dental surface are mutual
Calcification forms tooth stain after effect, and tooth stain not only influences the attractive in appearance of tooth, and can damage tooth and gum, cause tooth mobility with
And gum disease.Evening clothing shield gum toothpaste is designed and developed for these problems, can effectively be solved due to the difference of morning and evening oral environment
And the oral problem such as caused bacterial plaque, calculus dentalis, periodontosis, carious tooth, tooth stain.
American cockroach Periplaneta americana L. are Insecta Pterigota Blattaria Blattidae Periplaneta elder brother
Worm, it is one of three advantages worm kind of blattaria, is the ancient insect for spreading disease and inducing anaphylactia.Because of its medical value
Height, research of the domestic and foreign scholars to its extract are progressively deep into gene expression from simple medical value and clinical practice and divided
In terms of sub- biology.Its pharmacological action has anti-inflammatory, antibacterial, anti-oxidant, promotion organization reparation, treatment telephium and periodontitis
Effect.Have correlative study person once to American cockroach be made of primary raw material Kangfuxin Liquid treat ulcer, disease of digestive tract,
Periodontitis, all generate the effect of fine.American cockroach has certain natural antibacterial ingredient, antibacterial after being stimulated by exogenous induction material
Composition may showed increased, and American cockroach antibacterial peptide is not in general bacteriostasis to Escherichia coli, but killing action.
American-cockroach-extract is to tissue edema caused by inflammation and oozes out with obvious inhibitory action, and makees with significant analgesia
With.Confirm that American-cockroach-extract has the effect of anti-inflammation detumescence through pathological study.
Paeonol (Paeonol) is a kind of active ingredient extracted in the dry root skin of ranunculaceae peony.Its
Pharmacological action has antibacterial, anti-inflammatory, antipyretic and suppression allergy, in addition to swelling and pain relieving, antiallergy, anti-oxidant, hypnosis, drop blood
Pressure also has certain effect.
Magnolol Magnolia officinalis be the drying dry hide of the Magnoliacea plant bark of official magnolia or Magnolia bilola, root skin and
A kind of active ingredient extracted in branch skin, have good antibacterial, resisting pathogenic microbes, anti-inflammatory, antiulcer, it is anti-oxidant,
The pharmacological actions such as antitumor, suppression platelet aggregation.
The content of the invention
It is an object of the invention to provide evening clothing toothpaste of a kind of American-cockroach-extract-containing and preparation method thereof, manufactured tooth
Cream have it is antibacterial, go stain, pre- anti-caries, repair the effect of canker sore, firm tooth.
To reach this purpose, the technical solution adopted by the present invention is：A kind of evening clothing toothpaste of American-cockroach-extract-containing,
Include the raw material of following mass fraction：
Calcium monohydrogen phosphate 40.0~55.0%, D-sorbite 20.0~35.0%, glue 1.0~2.0%, sweetener 0~
2.0%, foaming agent 2.0~4.0%, KF88 0.02%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate
3.0%, sodium pyrophosphate 0.4%, American-cockroach-extract 1.0~4.0%, essence 0~0.3%, deionized water is surplus, above-mentioned
The summation of each component is 100%.
The glue is sodium carboxymethylcellulose and xanthans, and both mass ratioes are：Sodium carboxymethylcellulose:Xanthans=
2:1。
The sweetener is saccharin and xylitol, and both mass ratioes are saccharin:Xylitol=0.5:10.
The foaming agent is lauryl sodium sulfate and sodium lauroyl sarcosine, and both mass ratioes are：Dodecyl sulphur
Sour sodium:Sodium lauroyl sarcosine=2:1.
The essence is spearmint essence, is made up of the component of following masses percentage：Menthol 8.4%, peppermint oil
13.0%, spearmint oil 43.0%, fennel oil 21.5%, caryophyllus oil 9.0%, lemon oil 5.0%, vanillic aldehyde 0.1%.
The Paeonol extract is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
The magnolol extract is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
The American-cockroach-extract is obtained using semi-bionic extraction, specific as follows：
A, after dry American cockroach polypide is crushed, 100g is taken in flask, and the mass concentration for adding 6 times of quality is
95% ethanol handles 4h at 50 DEG C of normal pressure and bath temperature, and filtering, filter residue is put into baking oven, dries to constant weight, obtains in 50 DEG C
Filter residue I；
B, 3 kinds of cushioning liquid are prepared with citric acid and disodium hydrogen phosphate, pH is respectively 2.0,7.5,8.3, standby；
C, the 10g of filter residue I is weighed, the cushioning liquid that 200ml pH are 2.0 is added and is handled at 60 DEG C of normal pressure and bath temperature
1h, filtered, dried with step A method, obtain filter residue II, filtrate I；
D, filter residue II is extracted twice with the cushioning liquid that pH is 7.5,8.3 successively again with step C method, obtains filter residue
III, filtrate II, filter residue IV, filtrate III；
E, merging filtrate I, II, III, it is evaporated under reduced pressure and is concentrated under conditions of vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into when can also flow, in 80 DEG C of oven dryings to constant weight, produces the American-cockroach-extract of semi-bionic extraction method.
The American-cockroach-extract extracted by this method, it is left special different to eliminate cockroach in general extraction methods
Taste, and the active ingredient of American cockroach is remained to greatest extent, hence it is evident that improve its subjective feeling in the application.
Another object of the present invention is to a kind of preparation method for the evening clothing toothpaste for providing American-cockroach-extract-containing, comprising
Following steps：
1) material preparation of following mass fraction is pressed：
Calcium monohydrogen phosphate 40.0~55.0%, D-sorbite 20.0~35.0%, glue 1.0~2.0%, sweetener 0~
2.0%, foaming agent 2.0~4.0%, KF88 0.02%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate
3.0%, sodium pyrophosphate 0.4%, American-cockroach-extract 1.0~4.0%, essence 0~0.3%, deionized water is surplus, above-mentioned
The summation of each component is 100%；
2) D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, is heated to 80~90
DEG C 10~20min is kept, taken out after glue fully expands and be placed in cream pot processed and be cooled below 40 DEG C, glue is made；
3) in glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate is sequentially added, is stirred, obtains mixture；
4) Paeonol extract, magnolol extract extract, American cockroach extraction are added in the mixture of step 3)
Thing and essence, after stirring 10~20min, still aging 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
In the present invention, using American-cockroach-extract as core material, have and quickly repair canker sore well, resist
Scorching, analgesia, health-care effect；In addition using Paeonol extract honokiol extract as the auxiliary material of evening clothing toothpaste, more have
Effect ground reduces the bacterial number in oral cavity, reaches antibacterial effect.
The advantages of present invention possesses and effect：Added in the basic components of toothpaste a certain amount of American-cockroach-extract,
Paeonol extract honokiol extract, manufactured toothpaste have it is antibacterial, go stain, pre- anti-caries, repair canker sore, be firm
The effect of tooth.
Embodiment
To further illustrate technical scheme, this evening clothing toothpaste and its manufacture craft are carried out in detail below
Explanation.
Liquid component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
Fixation component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
American-cockroach-extract as described below is obtained using semi-bionic extraction, specific as follows：
A, dry American cockroach polypide is crushed with plant pulverizer, weighs 100g in pear-shaped flask, add 6 times of quality
Mass concentration be 95% ethanol, handle 4h at 50 DEG C of normal pressure and bath temperature, filter, filter residue is put into baking oven, in 50 DEG C
Dry to constant weight, obtain filter residue I；
B, 3 kinds of cushioning liquid are prepared with citric acid and disodium hydrogen phosphate, pH is respectively 2.0,7.5,8.3, standby；
C, the 10g of filter residue I is weighed, the cushioning liquid that 200ml pH are 2.0 is added and is handled at 60 DEG C of normal pressure and bath temperature
1h, filtered, dried with step A method, obtain filter residue II, filtrate I；
D, filter residue II is extracted twice with the cushioning liquid that pH is 7.5,8.3 successively again with step C method, obtains filter residue
III, filtrate II, filter residue IV, filtrate III；
E, merging filtrate I, II, III, it is evaporated under reduced pressure and is concentrated under conditions of vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into when can also flow, in 80 DEG C of oven dryings to constant weight, produces the American-cockroach-extract of semi-bionic extraction method.
Paeonol extract as described below is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
Magnolol extract as described below is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
Embodiment 1
1) material preparation of following mass fraction is pressed：
Calcium monohydrogen phosphate 46.0%, D-sorbite 25.0%, sodium carboxymethylcellulose 1.2%, xanthans 0.6%, saccharin
0.05%, xylitol 1.0%, lauryl sodium sulfate 2.2%, sodium lauroyl sarcosine 1.1%, KF88 0.02%, essence
0.3%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate 0.4%, American cockroach
Extract 2.5%, deionized water surplus；
The essence is spearmint essence, is made up of the component of following masses percentage：Menthol 8.4%, peppermint oil
13.0%, spearmint oil 43.0%, fennel oil 21.5%, caryophyllus oil 9.0%, lemon oil 5.0%, vanillic aldehyde 0.1%.
The Paeonol extract is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
The magnolol extract is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
2) D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, and is heated to 88 DEG C of guarantors
18min is held, taking-up, which is placed in cream pot processed, after glue fully expands is cooled below 40 DEG C, and glue is made；
3) in glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate is sequentially added, is stirred, obtains mixture；
4) Paeonol extract, magnolol extract extract, American cockroach extraction are added in the mixture of step 3)
Thing and essence, after stirring 16min, still aging 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
Embodiment 2
1) material preparation of following mass fraction is pressed：
Calcium monohydrogen phosphate 50.0%, D-sorbite 27.0%, sodium carboxymethylcellulose 1.6%, xanthans 0.8%, saccharin
0.05%, xylitol 1.0%, lauryl sodium sulfate 2.6%, sodium lauroyl sarcosine 1.3%, KF88 0.02%, essence
0.3%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate 0.4%, American cockroach
Extract 3.0%, deionized water surplus；
The essence is spearmint essence, is made up of the component of following masses percentage：Menthol 8.4%, peppermint oil
13.0%, spearmint oil 43.0%, fennel oil 21.5%, caryophyllus oil 9.0%, lemon oil 5.0%, vanillic aldehyde 0.1%.
The Paeonol extract is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
The magnolol extract is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
2) D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, and is heated to 90 DEG C of guarantors
20min is held, taking-up, which is placed in cream pot processed, after glue fully expands is cooled below 40 DEG C, and glue is made；
3) in glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate is sequentially added, is stirred, obtains mixture；
4) Paeonol extract, magnolol extract, American-cockroach-extract and perfume (or spice) are added in the mixture of step 3)
Essence, after stirring 20min, still aging 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
Embodiment 3
1) material preparation of following mass fraction is pressed：
Calcium monohydrogen phosphate 48.0%, D-sorbite 29.0%, sodium carboxymethylcellulose 1.4%, xanthans 0.7%, saccharin
0.05%, xylitol 1.0%, lauryl sodium sulfate 2.4%, sodium lauroyl sarcosine 1.2%, KF88 0.02%, essence
0.3%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate 0.4%, American cockroach
Extract 2.8%, deionized water surplus；
The essence is spearmint essence, is made up of the component of following masses percentage：Menthol 8.4%, peppermint oil
13.0%, spearmint oil 43.0%, fennel oil 21.5%, caryophyllus oil 9.0%, lemon oil 5.0%, vanillic aldehyde 0.1%.
The Paeonol extract is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
The magnolol extract is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
2) D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, and is heated to 80 DEG C of guarantors
10min is held, taking-up, which is placed in cream pot processed, after glue fully expands is cooled below 40 DEG C, and glue is made；
3) in glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate is sequentially added, is stirred, obtains mixture；
4) Paeonol extract, magnolol extract, American-cockroach-extract and perfume (or spice) are added in the mixture of step 3)
Essence, after stirring 10min, still aging 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
Embodiment 4
1) material preparation of following mass fraction is pressed：
Calcium monohydrogen phosphate 50.0%, D-sorbite 29.0%, sodium carboxymethylcellulose 1.6%, xanthans 0.8%, saccharin 0,
Xylitol 0, lauryl sodium sulfate 2.6%, sodium lauroyl sarcosine 1.3%, KF88 0.02%, essence 0, Paeonol extract
0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate 0.4%, American-cockroach-extract 2.0%, deionization
Water surplus；
The Paeonol extract is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C
Filtered after refrigerating 24h in refrigerator, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
The magnolol extract is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3
Secondary elution, is then concentrated with Rotary Evaporators, produces magnolol extract.
2) D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, and is heated to 85 DEG C of guarantors
15min is held, taking-up, which is placed in cream pot processed, after glue fully expands is cooled below 40 DEG C, and glue is made；
3) in glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate is sequentially added, is stirred, obtains mixture；
4) Paeonol extract, magnolol extract, American-cockroach-extract and perfume (or spice) are added in the mixture of step 3)
Essence, after stirring 15min, still aging 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
Test example：
First, bacteriostatic experiment
The toothpaste containing American-cockroach-extract prepared with embodiment 1-4 acts on porphyromonas gingivalis, white is read
Pearl bacterium, Streptococcus mutans, staphylococcus aureus, Escherichia coli and Bacillus acidi lactici are as test group, not add functional component
Blank toothpaste is as a control group.
1) subjects：Purchase the porphyromonas gingivalis in Institute of Micro-biology of Yunnan University, Candida albicans, variation chain
Coccus, staphylococcus aureus, Escherichia coli and Bacillus acidi lactici.
2) test procedures：Zengjing Granule is first carried out, the toothpaste of the preparation of 1g embodiments 1-4 is then respectively adding and does not add
The control toothpaste of American-cockroach-extract, Paeonol extract honokiol extract, the oscillation action through 2min, detection contrast
The quantity of front and rear bacterium.
3) result of the tests：After testing, the bacteriostasis property of toothpaste is up to 93.6%, experimental result such as following table：
4) conclusion (of pressure testing)s：The toothpaste acts on porphyromonas gingivalis, Candida albicans, Streptococcus mutans, golden yellow Portugal
The sterilizing rate of grape coccus, Escherichia coli and Bacillus acidi lactici is up to 93.6%, illustrates that the toothpaste has good fungistatic effect.
2nd, bacterial plaque evaluation test
1) experimental subjects：18-50 years old ages；Health；There is daily tooth-brushing habit；Cheek, the lingual surface of at least 20 teeth
It can record；Men and women is unlimited.Exclusion standard：The person that has systemic disease；Open dental caries, pulpitis, patients with periodontitis；Guan Qiao and just
Abnormal patient；In the gestational period and women breast-feeding their children；To toothpaste allergy and other dental health product allergy sufferers；Long-term use of antibiosis
Extract for treating person.
2) experiments packet：Experiment is carried out in accordance with the principle of random, double blinding, control.Qualified 50 subjects are pressed
The random digit of computer generation is grouped, 25 toothpaste prepared with embodiment 4 of test group, 25 same public affairs of use of control group
Department's production does not add American-cockroach-extract, the toothpaste of Paeonol extract honokiol extract.
3) test methods：Trier is brushed teeth using above-mentioned toothpaste, each 1cm of toothpaste length, 2 times a day, each 2min.
Experiment includes the evaluation (screening of 3 examination of mouth and plaque index (silness＆Loe plaque index, PLI)；At 0 week
Baseline estimate and latter stage is assessed at 6 weeks).Scaling on gum is carried out to all subjects after the evaluation of baseline periodontal.In baseline assessments
8h is without oral cleaning with before last evaluation, without using other oral hygiene measures during research.
4) check criteria and method：All inspections are carried out in clinical clinic, use mouth mirror, tweezers and periodontal probe pair
Subject carries out examination of mouth.Bacterial plaque dyeing is carried out to subject first.Method：5 drop coloring agent, instrucion are tested every time for everyone
Person makes coloring agent fully be contacted with facing containing 15s is gargled, and clear water is gargled, and then evaluates supragingival plaque situation using PLI.Each tooth
Also the soft tissue situation such as oral cavity lip, cheek, tongue is checked while weekly check, to evaluate the possibility pair of the toothpaste oral cavity soft tissue
Effect.
5) data processings：All data input computers, statistical analysis is carried out using SPSS10.0 softwares.With independence
The t check analyses evaluation of sample uses toothpaste PLI after 6 weeks situation.
6) result of the tests：48 subjects complete last experiment, and 2 subjects are due to having used other teeth halfway
Cream, therefore result can not be included in.
PLI changes situation before and after experiment：1. there was no significant difference (P ＞ 0.05) by test group and control group PLI before experiment.②
After testing 6 weeks, test group PLI reduced rates are 15.8%, and PLI statistically has significant difference (P ＜ 0.05) before and after experiment.
3. there was no significant difference (P ＞ 0.05) by PLI before and after control group experiment, see the table below：
7) conclusion (of pressure testing)s：Toothpaste prepared by embodiment 4 plays the role of to suppress bacterial plaque formation, that is, has pre- anti-caries and periodontal
The effect of sick.
3rd, stain is gone to test
By the use of toothpaste prepared by embodiment 1-4 as test group, not add American-cockroach-extract, Paeonol extract, thickness
The toothpaste of plain phenol extraction thing is as a control group.
1) experimental subjects：18-50 years old ages often smoking, have tea or drink coffee and have a trier 50 of obvious tooth stain
Name.
2) test requirements documents：It is required that trier brushes teeth 2 times, brush teeth 3min every time, carries out daily by tooth-brushing habit usually
12 weeks by a definite date on probation.
3) result of the tests：
As can be seen from the above table, it is believed that the more significant trier of stain-removing effect up to 72.5%, wherein have 25.0% it is on probation
Person thinks significant effect, and the trier for having 22.5% thinks that effect is smaller, and 5.0% trier thinks invalid.This tooth
Cream has preferable stain-removing effect.
Claims (9)
1. the evening clothing toothpaste of a kind of American-cockroach-extract-containing, it is characterised in that include the raw material of following mass fraction：
Calcium monohydrogen phosphate 40.0~55.0%, D-sorbite 20.0~35.0%, glue 1.0~2.0%, sweetener 0~2.0%, foaming agent
2.0~4.0%, KF88 0.02%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate
0.4%, American-cockroach-extract 1.0~4.0%, essence 0~0.3%, deionized water is surplus, and the summation of above-mentioned each component is
100%。
2. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The glue is carboxymethyl
Sodium cellulosate and xanthans, both mass ratioes are：Sodium carboxymethylcellulose:Xanthans=2:1.
3. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The sweetener is sugar
Essence and xylitol, both mass ratioes are saccharin:Xylitol=0.5:10.
4. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The foaming agent is ten
Sodium dialkyl sulfate and sodium lauroyl sarcosine, both mass ratioes are：Lauryl sodium sulfate:Sodium lauroyl sarcosine=2:
1。
5. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The essence is to stay orchid
Essence, it is made up of the component of following masses percentage：Menthol 8.4%, peppermint oil 13.0%, spearmint oil 43.0%, fennel oil
21.5%, caryophyllus oil 9.0%, lemon oil 5.0%, vanillic aldehyde 0.1%.
6. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The root bark of tree peony phenol extraction
Thing is made by following operation：
The water that 14 times of quality are added in moutan bark medicine materical crude slice carries out distillation extraction 5h, collects distillate, is placed on 4 DEG C of refrigerators
Filtered after middle refrigeration 24h, the crystallization of gained Paeonol is dried under reduced pressure at 45 DEG C produces Paeonol extract.
7. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The bark of official magnolia phenol extraction
Thing is made by following operation：
Bark of official magnolia coarse powder is subjected to ultrasonic extraction 2 times using ethyl acetate as solvent, each 30min, filtered after extraction, then through 3 leaching
Wash, then concentrated with Rotary Evaporators, produce magnolol extract.
8. the evening clothing toothpaste of American-cockroach-extract-containing according to claim 1, it is characterised in that：The American cockroach carries
Thing is taken to be obtained using semi-bionic extraction, it is specific as follows：
A, after dry American cockroach polypide is crushed, 100 g are taken in flask, the mass concentration for adding 6 times of quality is 95%
Ethanol handles 4h at 50 DEG C of normal pressure and bath temperature, and filtering, filter residue is put into baking oven, is dried in 50 DEG C to constant weight, obtains filter residue I；
B, 3 kinds of cushioning liquid are prepared with citric acid and disodium hydrogen phosphate, pH is respectively 2.0,7.5,8.3, standby；
C, the g of filter residue I 10 is weighed, the cushioning liquid that 200 ml pH are 2.0 is added and handles 1h at 60 DEG C of normal pressure and bath temperature,
Filtered, dried with step A method, obtain filter residue II, filtrate I；
D, filter residue II is extracted twice with the cushioning liquid that pH is 7.5,8.3 successively again with step C method, obtains filter residue III, filter
Liquid II, filter residue IV, filtrate III；
E, merging filtrate I, II, III, is evaporated under reduced pressure that be concentrated into can also under conditions of vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into during flowing, in 80 DEG C of oven dryings to constant weight, produces the American-cockroach-extract of semi-bionic extraction method.
9. the preparation method of the evening clothing toothpaste of any described American-cockroach-extract-containing of claim 1 to 8, it is characterised in that：
Comprise the steps of：
1）By the material preparation of following mass fraction：
Calcium monohydrogen phosphate 40.0~55.0%, D-sorbite 20.0~35.0%, glue 1.0~2.0%, sweetener 0~2.0%, foaming agent
2.0~4.0%, KF88 0.02%, Paeonol extract 0.3%, magnolol extract 1.0%, sodium phytate 3.0%, sodium pyrophosphate
0.4%, American-cockroach-extract 1.0~4.0%, essence 0~0.3%, deionized water is surplus, and the summation of above-mentioned each component is
100%；
2）D-sorbite is added in glue, homogenous disperse is uniform, adds deionized water and is well mixed, and is heated to 80~90 DEG C of guarantors
10~20min is held, is taken out after glue fully expands and is cooled below 40 DEG C, glue is made；
3）In glue, sweetener, foaming agent, KF88, calcium monohydrogen phosphate are sequentially added, is stirred, obtains mixture；
4）In step 3）Mixture in add Paeonol extract, magnolol extract, American-cockroach-extract and essence, stir
After mixing 10~20min, still aging 6h, aged substance is obtained；
5）By step 4）Aged substance be ground to after inspection do not measure particulate matter really up to the mark, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, produce the evening clothing toothpaste of American-cockroach-extract-containing.
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| CN109044916A (en) * | 2018-10-10 | 2018-12-21 | 广东心宝药业科技有限公司 | A kind of Pudilan toothpaste and preparation method thereof |
| CN110787078A (en) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | Toothpaste containing licoflavone and preparation method and application thereof |
| CN112691057A (en) * | 2020-12-23 | 2021-04-23 | 中国热带农业科学院热带作物品种资源研究所 | Compound functional toothpaste and preparation method thereof |
| CN113563985A (en) * | 2021-07-28 | 2021-10-29 | 北京中广恒峰国际商业有限公司 | Environment-friendly concentrated composite decontamination preparation and preparation method thereof |
| CN114948806A (en) * | 2021-07-23 | 2022-08-30 | 上海松皓生物科技有限公司 | Novel compound formula toothpaste containing fermented cockroach peptide and preparation method thereof |
| CN115154501A (en) * | 2022-06-20 | 2022-10-11 | 云南白药集团股份有限公司 | Composition for oral cavity repair, gel preparation prepared from composition and application of gel preparation |
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| CN113563985B (en) * | 2021-07-28 | 2023-08-22 | 北京中广恒峰国际商业有限公司 | Environment-friendly concentrated composite decontamination preparation and preparation method thereof |
| CN115154501A (en) * | 2022-06-20 | 2022-10-11 | 云南白药集团股份有限公司 | Composition for oral cavity repair, gel preparation prepared from composition and application of gel preparation |
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