CN114948806A - Novel compound formula toothpaste containing fermented cockroach peptide and preparation method thereof - Google Patents
Novel compound formula toothpaste containing fermented cockroach peptide and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of oral care, and particularly relates to a novel compound formula toothpaste containing fermented periplaneta peptide and a preparation method thereof. A novel compound formula toothpaste containing fermented cockroach peptide at least comprises the following preparation raw materials: at least one of traditional Chinese medicine extracting solution, cockroach peptide fermentation liquor, fermentation probiotics, an abrasive, a wetting agent and an auxiliary agent. The novel compound formula toothpaste containing the fermented cockroach peptide prepared by the invention integrates the functions of repairing, bacteriostasis, whitening, tooth strengthening and oral bacteria regulation, and can greatly improve the use value of the toothpaste; the novel compound formula toothpaste containing the fermented periplaneta peptide prepared by the invention has the advantages of obviously improving gingival bleeding, redness and swelling or inflammation symptoms, and further proving the anti-inflammatory effect of the toothpaste.
Description
Technical Field
The invention belongs to the technical field of oral care, and particularly relates to a novel compound formula toothpaste containing fermented periplaneta peptide and a preparation method thereof.
Background
Toothpaste is one of tooth cleaning products, generally in a gel shape, and is usually applied to a toothbrush, and the mechanical friction of the toothbrush is used for cleaning the surfaces of teeth, cleaning the teeth and the periphery of the teeth and purifying and refreshing the oral cavity. Tooth cleaning is most important for making teeth beautiful, protecting gum health, and preventing bad breath, and toothpaste has become a necessity of human daily life.
The national oral environment research shows that the tooth brushing rate of the Chinese population is 85.6 percent, but the adult who achieves the good index of oral hygiene is only 0.22 percent, the morbidity of periodontal diseases reaches 99.4 percent, and the symptoms of gingival bleeding, gingival swelling and pain, oral ulcer, periodontal diseases and the like are the common oral diseases of many Chinese people. The traditional toothpaste which demands mothproofing, whitening and cleaning cannot meet the increasingly diverse and complex oral environment of Chinese people. When toothpaste is sold as a cosmetic, consumers pay more attention to the appearance, flavor and taste of the product, and some functionalities and characteristics that cannot be directly perceived are often overlooked.
Therefore, in recent years, in the new national standards for toothpaste (GB 8372 + 2008) and the light industrial standards for efficacy toothpaste (QB 2966 + 2008) issued by China, the traditional Chinese medicine is allowed to enter the visual field for improving the oral problems of people in China, and the traditional Chinese medicine is gradually accepted by people with the characteristics of safety, effectiveness, comprehensive oral care and the like. Therefore, it is always the pursuit of research and development personnel to find toothpaste prepared from natural, safe and environment-friendly components with comprehensive tooth-strengthening, whitening, bacteriostasis and repairing functions.
Disclosure of Invention
In order to solve the technical problems, the invention provides a novel compound formula toothpaste containing fermented cockroach peptide in a first aspect, and the preparation raw materials at least comprise: at least one of traditional Chinese medicine extracting solution, cockroach peptide fermentation liquor, fermentation probiotics, an abrasive, a wetting agent and an auxiliary agent.
The preferable technical scheme is characterized in that the traditional Chinese medicine extracting solution comprises at least one of phellodendron amurense extracting solution, Chinese gall extracting solution, radix sophorae flavescentis extracting solution, fructus cnidii extracting solution, liquorice extracting solution, gentian extracting solution, borneol, scutellaria baicalensis extracting solution and bunge corydalis extracting solution.
As a preferred technical scheme, the weight ratio of the traditional Chinese medicine extracting solution to the cockroach peptide fermentation liquor to the fermented probiotics is (2-7): (1-3): 1.
as a preferred technical scheme, the weight ratio of the traditional Chinese medicine extracting solution to the cockroach peptide fermentation liquor to the fermented probiotics is 5: 2: 1.
as a preferred technical solution, the auxiliary agent comprises: binders, stabilizers, sweeteners, saccharin, surfactants; preferably, the preparation raw material also comprises deionized water.
As a preferable technical scheme, the adhesive is at least one selected from sodium carboxymethylcellulose, sodium alginate, chitosan, carrageenan, carbomer and chitosan oligosaccharide.
As a preferred technical scheme, the adhesive is sodium carboxymethyl cellulose.
As a preferable technical scheme, the substitution degree of the sodium carboxymethyl cellulose is 0.5-1.2; preferably, the degree of substitution is from 0.7 to 1.2.
As a preferred technical scheme, the preparation raw materials comprise the following components in percentage by weight: 2-7% of traditional Chinese medicine extracting solution, 1-3% of cockroach peptide fermentation liquor, 0.5-1.5% of fermentation probiotics, 15-35% of friction agent, 15-30% of wetting agent, 0.5-1.5% of adhesive, 0.1-0.5% of stabilizing agent, 0.1-1% of sweetening agent, 0.1-0.8% of saccharin, 1-3% of surfactant and the balance of deionized water to 100%.
The invention provides a preparation method of novel compound formula toothpaste containing fermented cockroach peptide, which comprises the following steps:
s1: adding deionized water into a sample preparation tank, sequentially adding the Chinese medicinal extractive solution, the Periplaneta peptide fermentation liquid, sweetener, saccharin, stabilizer and binder, stirring at normal temperature to dissolve completely, and transferring into a paste preparation pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding wetting agent, stirring with a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1-0.12 MPa, and continuing for 30-60 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging for 90-180 minutes at the temperature of less than or equal to 40 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
Has the advantages that: the novel compound formula toothpaste containing the fermented periplaneta peptide prepared by the invention has the following advantages:
1. the novel compound formula toothpaste containing the fermented cockroach peptide prepared by the invention integrates the functions of repairing, bacteriostasis, whitening, tooth strengthening and oral bacteria regulation, and can greatly improve the use value of the toothpaste;
2. the novel compound formula toothpaste containing the fermented cockroach peptide prepared by the invention can effectively inhibit the growth of streptococcus mutans and porphyromonas gingivalis by adding the traditional Chinese medicine extracting solution and the synergistic effect of the cockroach peptide fermenting solution and the fermented probiotics, thereby ensuring the health of the oral cavity and slowing down the phenomena of halitosis, oral ulcer and the like;
3. the novel compound formula toothpaste containing the fermented periplaneta peptide prepared by the invention has the advantages of obviously improving gingival bleeding, redness and swelling or inflammation symptoms, and further proving the anti-inflammatory effect of the toothpaste.
Detailed Description
In order to solve the technical problems, the invention provides a novel compound formula toothpaste containing fermented cockroach peptide in a first aspect, and the preparation raw materials at least comprise: at least one of traditional Chinese medicine extracting solution, cockroach peptide fermentation liquor, fermentation probiotics, an abrasive, a wetting agent and an auxiliary agent.
In some preferred embodiments, the starting materials for the preparation comprise: traditional Chinese medicine extracting solution, cockroach peptide fermentation liquor, fermentation probiotics, an abrasive, a wetting agent and an auxiliary agent.
In some preferred embodiments, the Chinese medicinal extract comprises at least one of phellodendron amurense extract, gallnut extract, sophora flavescens extract, fructus cnidii extract, liquorice extract, gentian extract, borneol, scutellaria baicalensis extract and bunge corydalis extract.
In some preferred embodiments, the Chinese medicinal extract comprises phellodendron amurense extract, gallnut extract, sophora flavescens extract, fructus cnidii extract, liquorice extract, gentian extract and borneol.
The traditional Chinese medicine extracting solution is purchased from Shanghai Hao Biotech limited.
In some preferred embodiments, the weight ratio of the traditional Chinese medicine extracting solution, the cockroach peptide fermentation liquor and the fermentation probiotics is (2-7): (1-3): 1.
in some preferred embodiments, the weight ratio of the traditional Chinese medicine extracting solution, the cockroach peptide fermentation liquid and the fermentation probiotics is 5: 2: 1.
in the experimental process, the applicant is researched by a large number of creative experiments, and the weight ratio of the traditional Chinese medicine extract, the cockroach peptide fermentation liquor and the fermentation probiotics in the application is (2-7): (1-3): 1, can promote the antibacterial effect of toothpaste greatly, the applicant conjectures that the possible reason is: hydrophobic groups or flavonoids existing in phellodendron amurense extract, Chinese gall extract, radix sophorae flavescentis extract, fructus cnidii extract, liquorice extract, gentian extract and borneol in the traditional Chinese medicine extract can separate bacterial cell membranes from phospholipid structures on mitochondria, destroy cell structures and enhance cell membrane permeability, so that intracellular ions and contents are leaked, and under the synergistic effect of cockroach peptide fermentation liquor and fermentation probiotics, the interference capability on bacterial membranes can be enhanced, and the sterilization effect on streptococcus mutans and porphyromonas gingivalis is further enhanced.
In some preferred embodiments, the fermented probiotic is fermented probiotic powder, available from rice biotechnology (guangzhou) limited.
In some preferred embodiments, the abrasive is selected from at least one of calcium carbamate, dibasic calcium phosphate dihydrate, silica, calcium carbonate, calcium pyrophosphate, and dibasic calcium phosphate.
In some preferred embodiments, the abrasive is calcium carbamate, dibasic calcium phosphate dihydrate.
In some preferred embodiments, the weight ratio of calcium carbamate to calcium hydrogen phosphate dihydrate is 3: (4-6).
In some preferred embodiments, the humectant is selected from at least one of glycerin, sorbitol, polyethylene glycol, and propylene glycol.
In some preferred embodiments, the humectant is glycerin.
In some preferred embodiments, the adjuvant comprises: binders, stabilizers, sweeteners, saccharin, surfactants; preferably, the preparation raw material also comprises deionized water.
In some preferred embodiments, the binder is selected from at least one of sodium carboxymethylcellulose, sodium alginate, chitosan, carrageenan, carbomer, and chitosan oligosaccharide.
In some preferred embodiments, the binder is sodium carboxymethyl cellulose.
In some preferred embodiments, the degree of substitution of the sodium carboxymethylcellulose is from 0.5 to 1.2.
In some preferred embodiments, the degree of substitution of the sodium carboxymethylcellulose is from 0.7 to 1.2.
In some preferred embodiments, the degree of substitution of the sodium carboxymethylcellulose is 0.9.
Sodium carboxymethylcellulose, degree of substitution 0.9, cat # C104979, available from Shanghai Allantin Biotech Co., Ltd.
In some preferred embodiments, the preparation raw materials comprise, in weight percent: 2-7% of traditional Chinese medicine extracting solution, 1-3% of cockroach peptide fermentation liquor, 0.5-1.5% of fermentation probiotics, 15-35% of friction agent, 15-30% of wetting agent, 0.5-1.5% of adhesive, 0.1-0.5% of stabilizing agent, 0.1-1% of sweetening agent, 0.1-0.8% of saccharin, 1-3% of surfactant and the balance of deionized water to 100%.
The invention provides a preparation method of novel compound formula toothpaste containing fermented cockroach peptide, which comprises the following steps:
s1: adding deionized water into a sample preparation tank, sequentially adding the Chinese medicinal extractive solution, the Periplaneta peptide fermentation liquid, sweetener, saccharin, stabilizer and binder, stirring at normal temperature to dissolve completely, and transferring into a paste preparation pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding wetting agent, stirring with a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1-0.12 MPa, and continuing for 30-60 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging for 90-180 minutes at the temperature of less than or equal to 40 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
Examples
Example 1
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 2% of traditional Chinese medicine extract, 1% of cockroach peptide fermentation liquor, 0.5% of fermented probiotics, 15% of abrasive, 15% of wetting agent, 0.5% of adhesive, 0.1% of stabilizer, 0.1% of sweetening agent, 0.1% of saccharin, 1% of surfactant and deionized water, and the balance is supplemented to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Songhua Biotechnology Limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the family of Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose, the degree of substitution is 0.9, the product number is C104979, and the adhesive is purchased from Shanghai Allantin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented cockroach peptide comprises the following steps:
s1: adding deionized water into a sample preparation tank, sequentially adding the Chinese medicinal extractive solution, the Periplaneta peptide fermentation liquid, sweetener, saccharin, stabilizer and binder, stirring at normal temperature to dissolve completely, and transferring into a paste preparation pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding a wetting agent, stirring by a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1 MPa, and continuing for 50 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging, wherein the aging time is 120 minutes, and the temperature is controlled to be 35 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
Example 2
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 7% of traditional Chinese medicine extract, 3% of cockroach peptide fermentation liquor, 1.5% of fermented probiotics, 35% of abrasive, 30% of wetting agent, 1.5% of adhesive, 0.5% of stabilizer, 1% of sweetening agent, 0.8% of saccharin, 3% of surfactant and deionized water, and the balance is up to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose with a degree of substitution of 0.9, a product number of C104979, and is available from Shanghai Aladdin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented cockroach peptide comprises the following steps:
s1: adding deionized water into a sample preparation tank, sequentially adding the Chinese medicinal extractive solution, the Periplaneta peptide fermentation liquid, sweetener, saccharin, stabilizer and binder, stirring at normal temperature to dissolve completely, and transferring into a paste preparation pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding a wetting agent, stirring by a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1 MPa, and continuing for 50 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging, wherein the aging time is 120 minutes, and the temperature is controlled to be 35 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
Example 3
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 5% of traditional Chinese medicine extracting solution, 2% of cockroach peptide fermentation liquor, 1% of fermentation probiotics, 24% of friction agent, 20% of wetting agent, 0.85% of adhesive, 0.35% of stabilizing agent, 0.5% of sweetening agent, 0.3% of saccharin, 2% of surfactant and deionized water, and the balance is added to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the family of Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose with a degree of substitution of 0.9, a product number of C104979, and is available from Shanghai Aladdin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented cockroach peptide comprises the following steps:
s1: adding deionized water into a sampling tank, sequentially adding the traditional Chinese medicine extract, the cockroach peptide fermentation liquor, the sweetener, saccharin, the stabilizer and the binder, stirring at normal temperature to dissolve completely, and transferring into a paste making pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding a wetting agent, stirring by a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1 MPa, and continuing for 50 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging, wherein the aging time is 120 minutes, and the temperature is controlled to be 35 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
Example 4
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 5% of traditional Chinese medicine extracting solution, 2% of cockroach peptide fermentation liquor, 1% of fermentation probiotics, 24% of friction agent, 20% of wetting agent, 0.85% of adhesive, 0.35% of stabilizing agent, 0.5% of sweetening agent, 0.3% of saccharin, 2% of surfactant and deionized water, and the balance is added to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the family of Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose with the degree of substitution of 1.2 and the product number of C104978, and is purchased from Shanghai Aladdin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented periplaneta peptide, which refers to example 3.
Example 5
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 1% of traditional Chinese medicine extracting solution, 2% of cockroach peptide fermentation liquor, 1% of fermentation probiotics, 24% of friction agent, 20% of wetting agent, 0.85% of adhesive, 0.35% of stabilizing agent, 0.5% of sweetening agent, 0.3% of saccharin, 2% of surfactant and deionized water, and the balance is supplemented to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose, the degree of substitution is 0.9, the product number is C104979, and the adhesive is purchased from Shanghai Allantin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented periplaneta peptide, which refers to example 3.
Example 6
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 5% of traditional Chinese medicine extracting solution, 1% of fermented probiotics, 24% of friction agent, 20% of wetting agent, 0.85% of adhesive, 0.35% of stabilizer, 0.5% of sweetening agent, 0.3% of saccharin, 2% of surfactant and deionized water, and the balance is up to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose, the degree of substitution is 0.9, the product number is C104979, and the adhesive is purchased from Shanghai Allantin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented periplaneta peptide, which refers to example 3.
Example 7
A novel compound formula toothpaste containing fermented cockroach peptide comprises the following preparation raw materials in percentage by weight: 1% of traditional Chinese medicine extracting solution, 1% of cockroach peptide fermentation liquor, 1% of fermented probiotics, 24% of friction agent, 20% of wetting agent, 0.85% of adhesive, 0.35% of stabilizing agent, 0.5% of sweetening agent, 0.3% of saccharin, 2% of surfactant and deionized water, and the balance is added to 100%.
The Chinese medicinal extractive solution comprises cortex Phellodendri extract, Galla chinensis extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, Glycyrrhrizae radix extract, radix Gentianae extract, and Borneolum Syntheticum.
Traditional Chinese medicine extract purchased from Shanghai Song Hao Biotech limited;
the cockroach peptide fermentation liquor is purchased from the biological technology (Guangzhou) of the Mike;
the fermented probiotics are fermented probiotic powder and are purchased from Weikang probiotics (Suzhou) GmbH;
the friction agent is calcium carbamate and calcium hydrophosphate dihydrate, and the weight ratio of the friction agent to the calcium hydrophosphate dihydrate is 3: 5.
the wetting agent is glycerol;
the adhesive is sodium carboxymethylcellulose, the degree of substitution is 0.9, the product number is C104979, and the adhesive is purchased from Shanghai Allantin Biotechnology GmbH;
the stabilizing agent is sodium pyrophosphate;
the sweetener is xylitol;
the surfactant is sodium lauroyl sarcosinate;
a preparation method of a novel compound formula toothpaste containing fermented periplaneta peptide, which refers to example 3.
And (3) performance testing:
1. the toothpaste prepared in example 3 of the present application was used for an antibacterial test, streptococcus mutans ATCC25175 and porphyromonas gingivalis ATCC 33277 were selected, an antibacterial performance test was performed by an agar plate dilution method, and the test results were recorded in table 1 below.
Table 1:
2. and (3) anti-allergy experiment: the perception dentin hypersensitivity is a subjective pain expression and has different responses to different stimuli, and the evaluation experiment adopts the evaluation from the aspects of subjective perception of dentin hypersensitivity pain, Schiff cold air sensitivity index and probing sensitivity improvement degree 3 of a subject every day, and records comparison before and after use.
Experimental materials: 100 toothpaste prepared in example 3 of the application;
control group: 30 Yunan white drug double-effect anti-allergy toothpastes;
subjects were eligible for inclusion criteria for healthy adult males and females: the group entry conditions are that the health condition of the whole body is good and no serious systemic diseases of the whole body exist; secondly, the testee appeals to cold, heat, acid and sweet stimulation sensitivity and pain caused by biting hard objects; age 18-60 years old. The subjects were confirmed by probing and cold water stimulation before the experiment.
90 qualified research objects are screened out according to the requirement of entering the group and divided into three groups (a blank group 30, a control group 30 and an experimental group 30), the experiment period, the morning and evening tooth brushing are carried out, the brushing is respectively tried for 2 weeks, 4 weeks and 6 weeks, and then the using effect is counted and recorded in the following table 2.
Table 2:
3. and (3) repairing experiment:
a rat model test is adopted, 12 rats are divided into two groups of blank control groups of 4 rats and an experimental group of 8 rats, 10% chloral hydrate is injected into the abdominal cavity for anesthesia and is fixed on a rat board, and model animals freely drink 10% high sugar water to form periodontitis. The blank control group had pure water. After confirming that periodontitis had formed in the rats, the rats were observed for red swelling and bleeding, and the toothpaste prepared in example 3 of the present application was applied as prescribed for 2 weeks.
And (3) effect detection: the gingival bleeding was observed by gently probing the inferior gingival margin with a periodontal probe and sliding, and scored according to the following scoring criteria. The upper left, mesial, palatal, and distal 3 sites of the rat were explored.
And (4) judging the standard:
1. the periodontal disease does not bleed, and the gum does not have red swelling;
2. the periodontal disease does not bleed, and the gum is slightly red and swollen;
3. periodontal punctate bleeding, gingival redness and swelling;
4. periodontal bleeding, gingival redness and swelling;
5. bleeding of the gums, which is a severe inflammation;
6. the gum bleeding automatically with ulcerated spots.
Table 3:
| grouping | Rat group | 1 | 2 | 3 | 4 | 5 | 6 |
| Blank space | 4 | 0 | 0 | 0 | 3 | 1 | 0 |
| Example 3 | 8 | 4 | 2 | 2 | 0 | 0 | 0 |
4. The sanitation index is as follows: the toothpaste prepared in examples 1 to 7 were subjected to a hygiene index test, in which the test method was described with reference to GB8372 and the results of the detection of colonies contained therein were recorded in the following table;
the total number of colonies in the specified detection result is less than or equal to 500CFU/mL and is marked as reaching the standard;
when the total number of colonies is more than 500CFU/mL, the colonies are marked as not reaching the standard;
and the results are reported in table 4 below.
Table 4:
| experiment of | Sanitation index |
| Example 1 | Reach the standard |
| Example 2 | Reach the standard |
| Example 3 | Reach the standard |
| Example 4 | Reach the standard |
| Example 5 | Does not reach the standard |
| Example 6 | Does not reach the standard |
| Example 7 | Does not reach the standard |
Note: the antibacterial performance test of the compound use of the traditional Chinese medicine extract and the fermented probiotics is carried out before the experiment:
and (3) antibacterial test: selecting Streptococcus mutans ATCC25175 and Porphyromonas gingivalis ATCC 33277;
preparation of test samples: two components with antibacterial effect are selected to prepare a sample, the traditional Chinese medicine extracting solution and the fermented probiotics (1:1 compound), and the rest components are water. The agar plate dilution method was used.
| Sample (I) | Concentration of | Streptococcus mutans | Porphyromonas gingivalis |
| Blank space | 0 | ++ | ++ |
| 1 | Containing 20% of compound liquid | - | - |
| 2 | Containing 10% of compound liquid | - | - |
| 3 | Containing 5% of compound liquid | - | - |
| 4 | Containing 2% of compound liquid | + | - |
The test result shows that: the 1:1 compound containing the Baibeishu and the fermented probiotics has poor effect on streptococcus mutans at the concentration of 2 percent, and has inhibition effect on streptococcus mutans at the concentration of 5 percent, so that the addition amount of the compound in the toothpaste is determined to be not less than 5 percent.
Claims (10)
1. A novel compound formula toothpaste containing fermented cockroach peptide is characterized by at least comprising the following preparation raw materials: at least one of traditional Chinese medicine extracting solution, cockroach peptide fermentation liquor, fermentation probiotics, an abrasive, a wetting agent and an auxiliary agent.
2. The novel compound toothpaste containing fermented cockroach peptide according to claim 1, wherein the Chinese herbal extract comprises at least one of phellodendron amurense extract, gallnut extract, sophora flavescens extract, fructus cnidii extract, liquorice extract, gentian extract, borneol, scutellaria baicalensis extract and bunge corydalis extract.
3. The novel fermented periplaneta peptide-containing compound toothpaste according to claim 1, wherein the weight ratio of the traditional Chinese medicine extract to the periplaneta peptide fermentation liquid to the fermented probiotics is (2-7): (1-3): 1.
4. the novel compound toothpaste containing fermented cockroach peptide formula of claim 3, wherein the weight ratio of the traditional Chinese medicine extract, the cockroach peptide fermentation liquid and the fermented probiotics is 5: 2: 1.
5. the novel compound toothpaste containing fermented cockroach peptide as claimed in claim 1, wherein the assistant comprises: binders, stabilizers, sweeteners, saccharin, surfactants; preferably, the preparation raw material also comprises deionized water.
6. The novel compound toothpaste containing fermented cockroach peptide as claimed in claim 5, wherein the binder is at least one selected from sodium carboxymethylcellulose, sodium alginate, chitosan, carrageenan, carbomer and chitosan oligosaccharide.
7. The novel compound toothpaste containing fermented periplaneta peptide formula as claimed in claim 6, wherein the binder is sodium carboxymethylcellulose.
8. The novel compound toothpaste containing fermented periplaneta peptide formula as claimed in claim 6 or 7, wherein the substitution degree of the sodium carboxymethylcellulose is 0.5-1.2; preferably, the degree of substitution is from 0.7 to 1.2.
9. The novel compound toothpaste containing fermented cockroach peptide according to claim 5, which is prepared from the following raw materials in percentage by weight: 2-7% of traditional Chinese medicine extracting solution, 1-3% of cockroach peptide fermentation liquor, 0.5-1.5% of fermentation probiotics, 15-35% of friction agent, 15-30% of wetting agent, 0.5-1.5% of adhesive, 0.1-0.5% of stabilizing agent, 0.1-1% of sweetening agent, 0.1-0.8% of saccharin, 1-3% of surfactant and the balance of deionized water to 100%.
10. The preparation method of the novel compound formula toothpaste containing the fermented periplaneta peptide according to claim 9, which is characterized by comprising the following steps:
s1: adding deionized water into a sample preparation tank, sequentially adding the Chinese medicinal extractive solution, the Periplaneta peptide fermentation liquid, sweetener, saccharin, stabilizer and binder, stirring at normal temperature to dissolve completely, and transferring into a paste preparation pot;
s2: then adding fermentation probiotics, and uniformly stirring;
s3: then adding wetting agent, stirring with a scraper, homogenizing, stirring, grinding, vacuumizing to-0.1-0.12 MPa, and continuing for 30-60 minutes;
s4: inspecting the product obtained in the step S3, adding the qualified product into a paste storage pot for aging for 90-180 minutes at the temperature of less than or equal to 40 ℃ to obtain an aged paste;
s5: and (6) subpackaging the paste obtained in the step S4 to obtain the ointment.
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