CN107362121A - A kind of anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing - Google Patents
A kind of anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing Download PDFInfo
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- CN107362121A CN107362121A CN201710603253.1A CN201710603253A CN107362121A CN 107362121 A CN107362121 A CN 107362121A CN 201710603253 A CN201710603253 A CN 201710603253A CN 107362121 A CN107362121 A CN 107362121A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention provides a kind of anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing, is characterised by：It is made up of the raw material of following mass fraction：Hydrated silica 42.0%-53.0%, excipient 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-1.5%, foaming agent 2.0%-4.0%, essence 0-0.3%, preservative 0.02%, Triclosan 0-0.2%, tranexamic acid 0-0.05%, American-cockroach-extract 0.5%-6.0%, Flos Chrysanthemi Indici extract 0.1%-1.5%, deionized water surplus, said components sum are 100%.Except addition American-cockroach-extract, with good anti-inflammatory, antibacterial, promotion organization reparation effect outside, also added Flos Chrysanthemi Indici extract, there is clearing heat and removing internal heat, antibacterial, anti-inflammatory, anti-oxidant, anti-mutation.
Description
Technical field
The present invention relates to a kind of toothpaste, especially a kind of anti-inflammatory antiulcer toothpaste and its system containing American-cockroach-extract
Make technique, belong to oral cleaning nursing article technical field.
Background technology
Oral inflammation belongs to a kind of common disease, such as periodontitis, gingivitis, periodontal abscess, fascial space infection of maxillofacial regions,
Although will not be fatal, the pain physiologically and psychic influence that give people to bring can not be ignored.Numerous studies show
Periodontal disease is caused by bacterium infection, and control plaque is the key for preventing oral inflammation.Clinically mainly controlled with Western medicine
Oral inflammation is treated, although this method is quick, bacterium can be made to produce drug resistance.With traditional Chinese medicine ingredients bacterium can be avoided to produce resistance to
The property of medicine and reach effectively treatment oral inflammation effect.
Toothpaste is daily life articles for use, and its main function is cleaning tooth, and protection oral hygiene is healthy.For many years
Come, it is more using Chinese herbal medicine or chemical reagent as functional component in tooth paste product, by the absorption of mucous membrane of mouth during brushing teeth, just
Reach the effect for cleaning the teeth and preventing and treating odontopathy.
American cockroach Periplaneta americana L. are Insecta Pterigota Blattaria Blattidae Periplaneta elder brother
Worm, it is one of three advantages worm kind of blattaria.Its extract is evident in efficacy, and toxic side effect is small, is gradually valued by people.Mesh
Research of the preceding domestic and foreign scholars to blattaria is more and more deep, and research finds have very by medicine prepared by raw material of American cockroach
Significant anti-inflammatory activity, being capable of promotion organization reparation.There is studies have shown that American-cockroach-extract to reduce rat bladder epithelium
Defect, rat bladder epithelium inflammatory cell infiltration is reduced, the bladder mucosa of damage is repaired, strengthens the barrier action of the bladder wall, with
Prevent inflammatory reaction.
Chrysanthemum indicum Chrysanthemum indicum L. are the perennial herb plants of composite family, Chrysanthemum, bitter, property
It is slightly cold, is a kind of conventional clearing heat and removing internal heat Chinese herbal medicine, it has clearing heat and detoxicating, dispelling wind improving eyesight and other effects.For these effects, China
History records are early on the books.Its excellent effects for removing toxic heat is by wide clinical application in inside and outside, woman, Er Deng sections disease.It is in day
There is positive effect with chemical industry.Its extract can suppress staphylococcus aureus, Escherichia coli, shigella dysenteriae, streptococcus,
The pathogenic bacteria such as lactobacillus.There is research to carry out solution heat test to rabbit by using Flos Chrysanthemi Indici extract, obtained good solution thermal effect
Fruit.
The present invention devises a effectively prevention and treatment oral inflammation for oral inflammation this problem and had to oral cavity
The toothpaste of certain health-care effect.
The content of the invention
It is an object of the invention to provide a kind of anti-inflammatory antiulcer toothpaste and its manufacture craft.
To reach this purpose, the technical solution adopted by the present invention is：A kind of anti-inflammatory of American-cockroach-extract-containing is anti-to burst
Ulcer toothpaste, is characterised by：It is made up of the raw material of following mass fraction：Hydrated silica 42.0% -53.0%, excipient
20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-1.5%, foaming agent 2.0%-4.0%, essence 0-
0.3%, preservative 0.02%, Triclosan 0-0.2%, tranexamic acid 0-0.05%, American-cockroach-extract
0.5% -6.0%, Flos Chrysanthemi Indici extract 0.1% -1.5%, deionized water surplus, said components sum is 100%.
Described excipient is glycerine and polyethylene glycol 400, and both mass ratioes are：Glycerine:Polyethylene glycol 400=1:1.
Described glue is sodium carboxymethylcellulose and Gantrez AN-119, and both mass ratioes are：Sodium carboxymethylcellulose:
Gantrez AN-119=1:1.
Described foaming agent is lauryl sodium sulfate and sodium lauroyl sarcosine, and both mass ratioes are：Dodecyl
Sodium sulphate:Sodium lauroyl sarcosine=1:1.
Described preservative is methyl p-hydroxybenzoate and butyl p-hydroxybenzoate, and both mass ratioes are：To hydroxyl
Yl benzoic acid methyl esters:Butyl p-hydroxybenzoate=1:1.
The essence is lemon extract, is made into by following component：Lemon oil 50.9%, orange oil 10.0%, fennel oil
15.0%, spearmint oil 12.0%, peppermint oil 12.0%, vanillic aldehyde 0.1%.
The anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing provided by the invention, is prepared by following process steps：
1) weighs raw material by prescription quality fraction：
Hydrated silica 42.0% -53.0%, excipient 20.0% -38.0%, glue 1.0% -2.0%, Aspartame
0-1.5%, foaming agent 2.0%-4.0%, essence 0-0.3%, preservative 0.02%, Triclosan 0-0.2%,
Tranexamic acid 0-0.05%, American-cockroach-extract 0.5%-6.0%, Flos Chrysanthemi Indici extract 0.1%-1.5%, deionization
Water surplus, said components sum are 100%；
2) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 80-90 DEG C are heated to, 10-20min is kept, makes sodium carboxymethylcellulose, PVM/MA
Copolymer fully expands, and is cooled to room temperature afterwards, obtains mixed liquor；
3) is in the mixed liquor of step 2), sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl
Yl benzoic acid butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon
Stone, stir, obtain mixture；
4) adds American-cockroach-extract and essence in the mixture of step 3), after stirring 10-20min, stands old
Change 6h, obtain aged substance；
5) aged substance of step 4) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
The extracting method of the American-cockroach-extract is as follows using semi-bionic extraction method：
1) after dry American cockroach polypide is crushed, it is put in flask, the mass concentration for adding 6 times of quality is 95%
Ethanol, 4h is handled at normal pressure, 50l DEG C of bath temperature, filtered, filter residue is put into baking oven, is dried in 50 DEG C to constant weight, obtains filter residue I；
2) three kinds of cushioning liquid that pH is respectively 2.0,7.5,8.3 are prepared with citric acid and disodium hydrogen phosphate, it is standby；
3) amount of 20ml cushioning liquid/g filter residues I is pressed, the cushioning liquid that pH is 2.0 is added in filter residue I, in normal pressure, water
1h is handled at 60 DEG C of bath temperature, is filtered, dried with the method for step 1), obtain filter residue II, filtrate I；
4) obtains filter residue III by filter residue II by being extracted twice with the cushioning liquid that pH is 7.5,8.3 successively step 3) described,
Filtrate II, filter residue IV, filtrate III；
5) merging filtrates I, II, III, is evaporated under reduced pressure that be concentrated into can also at vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into during flowing, in 80 DEG C of oven dryings to constant weight, produces American-cockroach-extract.
The American-cockroach-extract extracted by this method, it is left special different to eliminate cockroach in general extraction methods
Taste, and the active ingredient of American cockroach is remained to greatest extent, hence it is evident that improve its subjective feeling in the application.
The extracting method of the Flos Chrysanthemi Indici extract is as follows：
10 times of amounts of chrysanthemum indicum quality are pressed, the ethanol that mass fraction is 75% is added in chrysanthemum indicum, soaks 30min, in
70 DEG C of water-baths backflow 2h, filtering, obtain filtrate, the ethanol that the mass fractions that residue adds 10 times of amounts are 75%, water-bath 1h, filtering
Filtrate is obtained, merges secondary filtrate, is concentrated under reduced pressure into no ethanol flavor, produces Flos Chrysanthemi Indici extract.
The present invention has following advantages and effect：The present invention is except addition American-cockroach-extract, with anti-well
Inflammation, antibacterial, promotion organization reparation effect outside, also added Flos Chrysanthemi Indici extract, have clearing heat and removing internal heat, antibacterial, anti-inflammatory, antioxygen
Change, the effect of anti-mutation.
Embodiment
Technical scheme is described further below by embodiment.
Liquid component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
Fixation component used in the present invention, is not particularly illustrated, and is technical grade product purchased in market.
The extracting method of American-cockroach-extract as described below is as follows using semi-bionic extraction method：
1) crushes dry American cockroach polypide with plant pulverizer, weighs 100g in pear-shaped flask, adds 6 times of matter
The mass concentration of amount is 95% ethanol, and 4h is handled at normal pressure, 50 DEG C of bath temperature, is filtered, filter residue is put into baking oven, in 50 DEG C
Dry to constant weight, obtain filter residue I；
2) citric acids and disodium hydrogen phosphate prepare 3 kinds of cushioning liquid, and pH is respectively 2.0,7.5,8.3, standby；
3) weighs the 10g of filter residue I, adds the cushioning liquid that 200ml pH are 2.0, is handled at normal pressure, 60 DEG C of bath temperature
1h, filtered, dried with the method for step 1), obtain filter residue II, filtrate I；
4) extracts filter residue II twice with the method for step 3) with the cushioning liquid that pH is 7.5,8.3 successively again, obtains filter residue
III, filtrate II, filter residue IV, filtrate III；
5) merging filtrates I, II, III, is evaporated under reduced pressure that be concentrated into can also at vacuum -0.04MPa, 70 DEG C of bath temperature
Evaporating dish is poured into during flowing, in 80 DEG C of oven dryings to constant weight, produces American-cockroach-extract.
The extracting method of Flos Chrysanthemi Indici extract as described below is as follows：
5.00g chrysanthemum indicums are weighed, the ethanol that the mass fraction for adding 10 times of quality is 75% soaks 30min, in 70 DEG C of water
Bath backflow 2h, filtering, filtrate is obtained, the ethanol water bath 1h that the mass fraction that residue adds 10 times of amounts is 75%, is filtered to get filtrate,
Merge secondary filtrate, be concentrated under reduced pressure into no ethanol flavor and produce Flos Chrysanthemi Indici extract.
Essence as described below is lemon extract, is made into by following component：Lemon oil 50.9%, orange oil 10.0%, fennel
Oil 15.0%, spearmint oil 12.0%, peppermint oil 12.0%, vanillic aldehyde 0.1%.
Embodiment 1
Stocked up by following mass ratio：
Hydrated silica 45.0%, glycerine 12.0%, polyethylene glycol 400 12.0%, sodium carboxymethylcellulose 1.0%, PVM/
MA copolymer 1 .0%, Aspartame 0.1%, lauryl sodium sulfate 1.5%, sodium lauroyl sarcosine 1.5%, essence
0.3%, methyl p-hydroxybenzoate 0.01%, butyl p-hydroxybenzoate 0.01%, Triclosan 0.2%, ammonia first
Naphthenic acid 0.05%, Flos Chrysanthemi Indici extract 0.5%, American-cockroach-extract 2.5%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 80 DEG C are heated to, 18min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) is in the mixed liquor of step 1), sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl
Yl benzoic acid butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon
Stone, stir, obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 18min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Embodiment 2
Stocked up by following mass ratio：
Hydrated silica 51.0%, glycerine 14.0%, polyethylene glycol 400 14.0%, sodium carboxymethylcellulose 0.6%, PVM/
MA copolymers 0.6%, Aspartame 0.1%, lauryl sodium sulfate 1.0%, sodium lauroyl sarcosine 1.0%, para hydroxybenzene
Methyl formate 0.01%, butyl p-hydroxybenzoate 0.01%, essence 0.3%, Triclosan 0.2%, tranexamic acid
0.05%, Flos Chrysanthemi Indici extract 0.5%, American-cockroach-extract 3.0%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 85 DEG C are heated to, 15min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) is in the mixed liquor of step 1), sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl
Yl benzoic acid butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon
Stone, stir, obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 15min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Embodiment 3
Stocked up by following mass ratio：
Hydrated silica 50.0%, glycerine 16.0%, polyethylene glycol 400 16.0%, sodium carboxymethylcellulose 0.7%, PVM/
MA copolymers 0.7%, Aspartame 0.1%, lauryl sodium sulfate 1.25%, sodium lauroyl sarcosine 1.25%, to hydroxyl
Methyl benzoate 0.01%, butyl p-hydroxybenzoate 0.01%, essence 0.3%；Triclosan 0.2%, ammonia first ring
Acid 0.05%, Flos Chrysanthemi Indici extract 0.5%, American-cockroach-extract 3.5%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 90 DEG C are heated to, 10min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) is in the mixed liquor of step 1), sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl
Yl benzoic acid butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon
Stone, stir, obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 12min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Embodiment 4
Stocked up by following mass ratio：
Hydrated silica 47.0%, glycerine 15.0%, polyethylene glycol 400 15.0%, sodium carboxymethylcellulose 0.8%, PVM/
MA copolymers 0.8%, Aspartame 0.16%, lauryl sodium sulfate 1.6%, sodium lauroyl sarcosine 1.6%, para hydroxybenzene
Methyl formate 0.01%, butyl p-hydroxybenzoate 0.01%, essence 0%；Triclosan 0.2%, tranexamic acid
0.05%, Flos Chrysanthemi Indici extract 0.5%, American-cockroach-extract 4.0%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 87 DEG C are heated to, 12min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) is in the mixed liquor of step 1), sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl
Yl benzoic acid butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon
Stone, stir, obtain mixture；
3) adds American-cockroach-extract and essence in the mixture of step 2), still aging after stirring 13min
6h, obtain aged substance；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Embodiment 5
Stocked up by following mass ratio：
Hydrated silica 48.0%, glycerine 17.0%, polyethylene glycol 400 17.0%, sodium carboxymethylcellulose 1.0%, PVM/
MA copolymer 1 .0%, Aspartame 0, lauryl sodium sulfate 1.5%, sodium lauroyl sarcosine 1.5%, P-hydroxybenzoic acid
Methyl esters 0.01%, butyl p-hydroxybenzoate 0.01%, essence 0；Triclosan 0.2%, tranexamic acid 0.05% are wild
Chrysanthemum extract 0.5%, American-cockroach-extract 4.5%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 83 DEG C are heated to, 20min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) sequentially adds tranexamic acid, methyl p-hydroxybenzoate, P-hydroxybenzoic acid in the mixed liquor of step 1)
Butyl ester, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydrated silica, fully
Stir, obtain mixture；
3) adds American-cockroach-extract in the mixture of step 2), after stirring 20min, still aging 6h, obtains old
Compound；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Embodiment 6
Stocked up by following mass ratio：
Hydrated silica 43.0%, glycerine 16.0%, polyethylene glycol 400 16.0%, sodium carboxymethylcellulose 0.75%,
Gantrez AN-119 0.75%, Aspartame 0, lauryl sodium sulfate 1.4%, sodium lauroyl sarcosine 1.4%, para hydroxybenzene
Methyl formate 0.01%, butyl p-hydroxybenzoate 0.01%, essence 0；Triclosan 0, tranexamic acid 0, chrysanthemum indicum
Extract 0.5%, American-cockroach-extract 5.0%, deionized water surplus.
By following each step：
1) mixes above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous
It is even, after adding deionized water mixing, 88 DEG C are heated to, 17min is kept, fills sodium carboxymethylcellulose, Gantrez AN-119
Divide expansion, be cooled to room temperature afterwards, obtain mixed liquor；
2) sequentially adds methyl p-hydroxybenzoate, butyl p-hydroxybenzoate, 12 in the mixed liquor of step 1)
Sodium alkyl sulfate, sodium lauroyl sarcosine, hydrated silica, are stirred, and obtain mixture；
3) adds American-cockroach-extract in the mixture of step 2), after stirring 17min, still aging 6h, obtains old
Compound；
4) aged substance of step 3) is ground to after inspection do not measure grit thing by, be evacuated to vacuum not less than-
0.096MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
Test example：
First, bacteriostatic test
Gum porphin is acted on the toothpaste containing American-cockroach-extract and Flos Chrysanthemi Indici extract prepared by embodiment 3-6
Quinoline monad, Candida albicans, Streptococcus mutans, staphylococcus aureus, Escherichia coli and Bacillus acidi lactici as test group, with
Not plus functional component blank toothpaste as a control group.
1) experimental subjects：Purchase the porphyromonas gingivalis, Candida albicans, golden yellow in Institute of Micro-biology of Yunnan University
Staphylococcus.
2) experimental procedures：Zengjing Granule is first carried out, be then respectively adding the preparation of 1g embodiments 3-6 contains American cockroach
The toothpaste of extract and the control toothpaste for being not added with American-cockroach-extract, the oscillation action through 2min are thin before and after detection contrast
The quantity of bacterium.
3) result of the tests：After testing, the bacteriostasis property of toothpaste is up to 93.1%, experimental result such as following table：
4) conclusion (of pressure testing)s：
The toothpaste acts on porphyromonas gingivalis, Candida albicans and the sterilizing rate of staphylococcus aureus and is up to
93.2%, illustrate that the toothpaste has good fungistatic effect.
2nd, clinical test
The toothpaste containing American-cockroach-extract and Flos Chrysanthemi Indici extract prepared with embodiment 3-6 is used to treat oral cavity
The experimental data of ulcers：
1) subjects：
20-65 years old recurrent aphthous ulcer (RAU) patients 50 are selected, are randomly divided into test group 40 and control group
10, test group is divided into every group of 10 people of 4 groups again.Subject is to meet to include and the healthy adult male of exclusion standard and female
Property.
2) inclusive criterias：
1. whole body health in order, has RAU morbidity histories；
2. it can be recorded during experiment according to test requirements document and participate in inspection at any time；
3. at least one canker sore in oral cavity, and ulcer time of origin is less than 48h；
4., must not be for the gestational period and nursing period if women；
5. will not allergy to toothpaste and its composition；
6. without other treatment stomatocace medicine is used, other are not participated in similar to experimental study simultaneously.
3) exclusion standards：
1. heavy recurrent RAU, Behcet's disease；
2. systemic disease background：Anaemia, peptic ulcer, clone's disease, acute infectious diseases, autoimmune disease
Deng；
3. antalgesic or treatment stomatocace medicine are used in 24 hours；
4. using antibiotic, antiphlogistic in 1 month, whole body uses corticosteroid, immunodepressant in 3 months；
5. smoking, alcoholic in 3 months；
6. tumor patient；
7. there are allergies to oral health care product or its composition.
4) evaluation indexes：
1. the ulcerative stage that is averaged (my god, D)：Evaluate period each ulcer duration summation divided by ulcer sum；
2. pain index (point, P)：Using the daily pain scores of Visual analogue scale (VAS) record ulcerative stage.
VAS is meant that the straight line using 10cm, and 0 end of straight line represents " painless ", and 10cm ends represent " most violent pain
Bitterly ", subject is different according to the level of sensitivity of pain, is kept a record in the corresponding scale of straight line, 1 time a day.
5) evaluation indexes are classified：
①D1：Average ulcerative stage shortens (t is examined, P ＜ 0.05)；
②D0：Average ulcerative stage is without change (t is examined, P ＞ 0.05)；
③P1：Pain index reduces (t is examined, P ＜ 0.05)；
④P0：Pain index is without change (t is examined, P ＞ 0.05).
6) evaluation criterions：
It is 1. effective：D1P1；
It is 2. effective：D1P0 or D0P1；
It is 3. invalid：D0P0.
7) test methods：
20~65 years old canker sore patient is filtered out from population and is used as subjects for totally 50, is randomly divided into experiment
Group (embodiment 3-6 prepare the toothpaste containing American-cockroach-extract with Flos Chrysanthemi Indici extract) and control group (be free of effect into
The ordinary toothpaste divided).
Patient is taught first and records pain index, issues " canker sore record sheet ", while records subject's telephone number,
Issue everyone a set of toothpaste, toothbrush, advise three before the meal 10min toothpaste is applied to affected part, fed again after being gargled after 5min.It is early daily
Evening twice, is brushed teeth with sent out toothpaste according to oneself traditional approach.
Call-on back by phone then is carried out to subject daily, ulcer is understood and develops and supervise record " canker sore record sheet ".
After canker sore recovery from illness, carry out canker sore inspection and reclaim " canker sore record sheet ".
Experiment uses double-blind study.I.e. examiner and subject complete experiment in the case where not knowing packet.
Data are arranged, input computer simultaneously carries out statistical analysis.
8) result of the tests：
1. baseline compares：
Test group 40, is divided into 4 groups, each group 10, and each group uses its of the preparation of embodiment 3-6 respectively
A kind of middle toothpaste；Control group 10, use the blank toothpaste without functional component.Two groups of subject ages and initial ulcer size
Etc. without significant difference (being shown in Table 1), illustrate that two groups have neat same comparativity.
2. averagely ulcerative stage：
The average ulcerative stage of test group is 6.23-6.65 days, and control group is 7.24 days, through each test group of statistical test and
There is significant difference (P ＜ 0.05) (being shown in Table 2) between control group.
3. pain index：
Test group pain index is 3.68-3.82, control group 4.46, through each test group of statistical test and control group
Between there are significant differences (P ＜ 0.01) to be shown in Table 3.
9) conclusion (of pressure testing)s：
Test group is compared with control group, and the average ulcerative stage of subject shortens, and pain index reduces, and evaluation criterion is aobvious.Say
The bright toothpaste has good anti-inflammatory antiulcer action.
Claims (9)
- A kind of 1. anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing, it is characterised in that：By the raw material system of following mass fraction Into：Hydrated silica 42.0%-53.0%, excipient 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-1.5%, foaming Agent 2.0%-4.0%, essence 0-0.3%, preservative 0.02%, Triclosan 0-0.2%, tranexamic acid 0-0.05%, American-cockroach-extract 0.5% -6.0%, Flos Chrysanthemi Indici extract 0.1% -1.5%, deionized water surplus, said components sum are 100%。
- 2. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described figuration Agent is glycerine and polyethylene glycol 400, and both mass ratioes are：Glycerine:Polyethylene glycol 400=1:1.
- 3. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described glue is Sodium carboxymethylcellulose and Gantrez AN-119, both mass ratioes are：Sodium carboxymethylcellulose:Gantrez AN-119=1:1.
- 4. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described foaming Agent is lauryl sodium sulfate and sodium lauroyl sarcosine, and both mass ratioes are：Lauryl sodium sulfate:Hamposyl L Sodium=1:1.
- 5. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that described anti-corrosion Agent is methyl p-hydroxybenzoate and butyl p-hydroxybenzoate, and both mass ratioes are：Methyl p-hydroxybenzoate:To hydroxyl Butyl benzoate=1:1.
- 6. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the essence is Lemon extract, it is made into by following component：Lemon oil 50.9%, orange oil 10.0%, fennel oil 15.0%, spearmint oil 12.0% are thin Lotus oil 12.0%, vanillic aldehyde 0.1%.
- 7. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that pass through following work It is prepared by skill step：1）Raw material is weighed by prescription quality fraction：Hydrated silica 42.0%-53.0%, excipient 20.0%-38.0%, glue 1.0%-2.0%, Aspartame 0-1.5%, foaming Agent 2.0%-4.0%, essence 0-0.3%, preservative 0.02%, Triclosan 0-0.2%, tranexamic acid 0-0.05%, American-cockroach-extract 0.5% -6.0%, Flos Chrysanthemi Indici extract 0.1% -1.5%, deionized water surplus, said components sum are 100%；2）Above-mentioned standby sodium carboxymethylcellulose, Gantrez AN-119, glycerine and polyethylene glycol 400 elder generation homogeneous are mixed, After adding deionized water mixing, 80-90 DEG C are heated to, 10-20 min is kept, makes sodium carboxymethylcellulose, PVM/MA common Polymers fully expands, and is cooled to room temperature afterwards, obtains mixed liquor；3）In step 2）Mixed liquor in, sequentially add Aspartame, tranexamic acid, methyl p-hydroxybenzoate, to hydroxyl Butyl benzoate, Flos Chrysanthemi Indici extract, lauryl sodium sulfate, sodium lauroyl sarcosine, Triclosan, hydration silicon Stone, stir, obtain mixture；4）In step 3）Mixture in, add American-cockroach-extract and essence, it is still aging after stirring 10-20 min 6 h, obtain aged substance；5）By step 4）Aged substance be ground to after inspection do not measure grit thing, be evacuated to vacuum not less than -0.096 MPa, it is filling, examine, obtain the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing.
- 8. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the America is big Lian extracts extract with the following method：1）After dry American cockroach polypide is crushed, it is put in flask, the mass concentration for adding 6 times of quality is 95% ethanol, 4 h are handled at normal pressure, 50l DEG C of bath temperature, are filtered, filter residue is put into baking oven, is dried in 50 DEG C to constant weight, obtains filter residue I；2）Three kinds of cushioning liquid that pH is respectively 2.0,7.5,8.3 are prepared with citric acid and disodium hydrogen phosphate, it is standby；3）By the amount of 20 ml cushioning liquid/g filter residues I, the cushioning liquid that pH is 2.0 is added in filter residue I, in normal pressure, water-bath temperature 1 h is handled at 60 DEG C of degree, with step 1）Method filtering, dry, obtain filter residue II, filtrate I；4）Filter residue II is pressed into step 3）It is described to be extracted twice with the cushioning liquid that pH is 7.5,8.3 successively, obtain filter residue III, filtrate II, filter residue IV, filtrate III；5）Merging filtrate I, II, III, it is evaporated under reduced pressure at the MPa of vacuum -0.04,70 DEG C of bath temperature and is concentrated into and can also flow Evaporating dish is poured into when dynamic, in 80 DEG C of oven dryings to constant weight, produces American-cockroach-extract.
- 9. the anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing as claimed in claim 1, it is characterised in that the chrysanthemum indicum The extracting method of extract is as follows：10 times of amounts of chrysanthemum indicum quality are pressed, the ethanol that mass fraction is 75% is added in chrysanthemum indicum, 30 min are soaked, in 70 DEG C Water-bath 2 h of backflow, filtering, filtrate is obtained, the ethanol that the mass fractions that residue adds 10 times of amounts are 75%, the h of water-bath 1, is filtered Filtrate, merge secondary filtrate, be concentrated under reduced pressure into no ethanol flavor, produce Flos Chrysanthemi Indici extract.
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| CN108295121A (en) * | 2018-02-13 | 2018-07-20 | 云南诺漫斯生物科技有限公司 | A kind of American cockroach film for treating oral ulcer agent and preparation method thereof |
| CN111643439A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Efficient toothpaste for preventing and treating dental ulcer |
| CN113456567A (en) * | 2021-04-30 | 2021-10-01 | 唐山青木生物科技有限公司 | Periplaneta americana mouthwash and preparation method thereof |
| CN114948806A (en) * | 2021-07-23 | 2022-08-30 | 上海松皓生物科技有限公司 | Novel compound formula toothpaste containing fermented cockroach peptide and preparation method thereof |
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