CN107320428B - Toothpaste for balancing oral micro-ecology - Google Patents
Toothpaste for balancing oral micro-ecology Download PDFInfo
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- CN107320428B CN107320428B CN201710582355.XA CN201710582355A CN107320428B CN 107320428 B CN107320428 B CN 107320428B CN 201710582355 A CN201710582355 A CN 201710582355A CN 107320428 B CN107320428 B CN 107320428B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Oral & Maxillofacial Surgery (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses toothpaste for balancing oral micro-ecology, which is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine; the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 11-16: 5-9: 0.5 to 0.9. The toothpaste has comprehensive and remarkable efficacy and good biocompatibility, and can balance oral micro-ecology and comprehensively maintain oral health.
Description
Technical Field
The invention relates to toothpaste for balancing oral micro-ecology.
Background
The toothpaste is used as a daily oral cleaning product, comprises common abrasives, a humectant, a thickening agent, a surfactant and the like, and has the basic functions of cleaning the oral cavity, reducing soft dirt and the like. With the increasing working pressure, the influence of poor diet and cleaning habits, people are easy to have oral problems such as gum swelling and pain, bleeding, sensitivity to acid and cold, halitosis and canker sore, the quality of life is affected, and if the oral problems are not treated in time, the oral problems such as periodontitis and even tooth loss are aggravated.
With the benefit of scientific development, more and more research has shown that the most prominent train of leads for oral problems is oral flora imbalance. Oral microorganisms such as Porphyromonas gingivalis, Treponema denticola, Probiota nigricans, Enterobacter, Streptococcus mutans, Actinomyces viscosus, and Fusobacterium nucleatum have been implicated in gingivitis, oral ulcer, and halitosis. There are many kinds of toothpaste with various additives in the market, but there are few toothpaste with complete and obvious efficacy and good biocompatibility. Therefore, the toothpaste focuses on improving the oral micro-ecology, develops the toothpaste which can comprehensively maintain the oral health and simultaneously conforms to the living and working habits of people, and has high market value.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, provides the toothpaste for balancing oral microecology, and solves the problems of single and insignificant effect, low biocompatibility, short shelf life and the like in the background art.
The technical scheme adopted by the invention for solving the technical problems is as follows: 1. the toothpaste for balancing oral micro-ecology is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine;
the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, wherein the molecular weight of the carboxymethyl chitin is 2-5 ten thousand.
In a preferred embodiment of the present invention, the mass ratio of the panax notoginseng root extract, the propolis extract and the carboxymethyl chitin is 11-16: 5-9: 0.5 to 0.9.
In a preferred embodiment of the present invention, the preparation method of the american ginseng extract comprises: extracting radix Panacis Quinquefolii to obtain saponin, drying, pulverizing, adding appropriate amount of aqueous solution containing ammonium sulfate and dipotassium hydrogen phosphate, mixing, sterilizing, inoculating mixed zymocyte seed solution of Aspergillus niger and Bacillus subtilis, fermenting for 20 days, terminating fermentation, and sterilizing.
In a preferred embodiment of the present invention, the preparation method of the propolis extract comprises: adding crude propolis into 7 times of boiling water, stirring for 3 hr, cooling to 22-25 deg.C, and removing wax layer and water layer to obtain wax-removed propolis; extracting wax-removed propolis with 8 times of 70% ethanol at constant temperature of 60 deg.C for 3 times, each time for 2 hr. Combining the leaching liquor for 3 times, and mixing the propolis leaching liquor: preparing the propolis extract according to the water mass ratio of 1: 10.
In a preferred embodiment of the present invention, the composition further comprises 0.01 to 0.1 part of saccharin sodium.
In a preferred embodiment of the present invention, the composition further comprises 0.05 to 0.5 parts of a preservative.
In a preferred embodiment of the present invention, the liquid composition further comprises 0.01 to 0.05 parts of essence.
In a preferred embodiment of the present invention, the mass ratio of the panax notoginseng root extract, the propolis extract and the carboxymethyl chitin is 11: 5: 0.5.
compared with the background technology, the technical scheme has the following advantages:
1. american ginseng is widely used in the world as a precious Chinese medicinal material, but is more directed to the application of saponin contained in the American ginseng. However, the American ginseng has other beneficial components such as saccharides besides saponin, and researches show that the American ginseng after extracting the saponin component can obtain the active component of the American ginseng oligosaccharide through specific fermentation conditions.
2. The propolis extract and the carboxymethyl chitin are matched with the American ginseng extract to enhance the bacteriostatic effect of the product on candida albicans. The propolis extract and the carboxymethyl chitin with low molecular weight have bacteriostatic ability on candida albicans, but the minimum bacteriostatic concentration of the propolis extract is higher than that of the carboxymethyl chitin with low molecular weight, and the taste is not pleasant. The three components are matched according to proper proportion through repeated experiments, and the comprehensiveness and the significance of the efficacy of the toothpaste are greatly improved.
3. The active composition is extracted from nature, animals and plants by combining modern biotechnology, has good biodegradability and biocompatibility, is suitable for proportion matching, and greatly increases the comprehensiveness and significance of the efficacy of the toothpaste.
Detailed Description
The present invention will be described in detail with reference to the following examples:
example 1
A toothpaste for balancing oral microecology comprises 18% of calcium hydrogen phosphate dihydrate, 25% of hydrated silica, 23% of sorbitol, 12% of glycerol, 1% of sodium lauryl sulfate, 0.3% of cellulose gum, 0.3% of hydroxyethyl cellulose, 0.06% of sodium saccharin, 0.1% of sodium monofluorophosphate (calculated by fluorine), 0.05% of tetrasodium pyrophosphate, 1% of active composition, 0.05% of essence, 0.4% of sodium benzoate and the balance of deionized water. Wherein the American ginseng root extract: propolis extract: the mass ratio of the carboxymethyl chitin is 11: 5: 0.5.
1) weighing the raw materials according to the formula dosage of 1000g for later use;
2) putting sorbitol, glycerol, cellulose gum and hydroxyethyl cellulose into a glue pot, wetting and stirring, adding the dissolved saccharin sodium, deionized water and other raw materials, continuously stirring to enable the prepared glue to be in a uniform, semitransparent and sticky liquid state, and then storing to enable the glue to be fully dissolved and expanded for use;
3) adding the active composition, the various solid powdery raw materials, the prepared glue, essence and the like into a blocking pot according to the formula and operation requirements, and mechanically mixing and uniformly stirring to prepare a paste with certain viscosity and proper thickness;
4) grinding the paste by a grinder, grinding coarse and hard particles to make the paste fine, uniform and stable, vacuum degassing after grinding, and standing for a period of time to obtain the product.
The toothpaste of this example was taken for evaluation experiments:
(1) the toothpaste efficacy clinical evaluation for inhibiting dental plaque and relieving gingivitis.
By adopting a random and double-blind test method, a test group is the toothpaste prepared in the embodiment (marked as group A), a control group is the China double-calcium anti-caries toothpaste produced by the company Rihua Limited (marked as group B), a clinical examination indicates dental plaque (Q-H dental plaque index, P L I) and gingivitis (gingival index, GI), the two training elements are all the same, and an oral cavity treating doctor skilled in operation performs oral cavity examination, and after screening for 150 people, subjects use the corresponding toothpaste and toothbrush respectively, and review the corresponding indexes after 1 week, 3 months and 6 months respectively to evaluate the effect.
In the test process, 14 people are rejected because toothpaste is not used according to the test requirement, and finally 136 people complete the test in the whole 6 months and are included in the statistical analysis. The test results are shown in tables 1 and 2.
TABLE 1 evaluation of dental plaque
The results show that the mean plaque index of the subjects was statistically significant (P < 0.05) between the two groups using this example and the control.
TABLE 2 evaluation of gingivitis
The results show that the mean of the gingival indices of the subjects at month 3 and month 6 are statistically significant (P < 0.05) in the differences between the use of this example and the control.
From the above two results, the toothpaste prepared in this example has better plaque reduction and gingivitis reduction effects than the zhonghua double calcium toothpaste. The formula tables of the two are analyzed to show that the formulas of the two are basically consistent except for the active composition, which indicates that the toothpaste efficacy can be obviously improved by adding the active composition.
(2) Evaluation of halitosis and canker sore effects.
Because the subjective judgment of the change of halitosis and oral ulcer is strong, the evaluation adopts the subjective judgment of the testee. The halitosis person 25 and the canker sore person 31 require brushing their teeth in the morning and evening, brushing their tongue with the toothbrush 5 times, and judging after 10 days. The results are shown in Table 3.
TABLE 3 halitosis and canker sore Effect
| Has the effects of | Effective but not obvious | Without effect | |
| Improving halitosis | 19 | 3 | 3 |
| Improving oral ulcer | 26 | 2 | 3 |
The results show that more than half of the subjects think that the toothpaste prepared by the embodiment can improve halitosis and canker sore. The effect of the product as a product for daily maintenance of oral health is proved.
Example 2
Example 2 differs from example 1 in that: the toothpaste of this example comprises 20% of dibasic calcium phosphate dihydrate, 20% of hydrated silica, 30% of sorbitol, 20% of glycerin, 2% of sodium lauryl sulfate, 0.1% of cellulose gum, 0.1% of hydroxyethyl cellulose, 0.03% of sodium saccharin, 0.1% of sodium monofluorophosphate (calculated as fluorine), 0.0.01% of tetrasodium pyrophosphate, 0.5% of an active composition, 0.03% of an essence, 0.5% of sodium benzoate, and the balance of deionized water. The active composition consists of a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 13:9: 0.7.
According to clinical evaluation, the toothpaste of the embodiment can inhibit dental plaque, relieve gingivitis, and reduce halitosis and canker sore.
Example 3
Example 3 differs from example 1 in that: in the toothpaste of the present embodiment, the calcium hydrogen phosphate dihydrate is 15%, the hydrated silica is 30%, the sorbitol is 20%, the glycerol is 10%, the sodium lauryl sulfate is 3%, the cellulose gum is 1%, the hydroxyethyl cellulose is 1%, the saccharin sodium is 0.05%, the sodium monofluorophosphate is 0.1% (calculated by fluorine), the tetrasodium pyrophosphate is 0.5%, the active composition is 2.0%, the essence is 0.05%, the sodium benzoate is 0.5%, and the balance is deionized water. The active composition consists of a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 16:7: 0.9.
According to clinical evaluation, the toothpaste of the embodiment can inhibit dental plaque, relieve gingivitis, and reduce halitosis and canker sore.
It will be appreciated by those skilled in the art that the same or similar technical effects as those of the above embodiments can be expected when the technical parameters of the present invention are changed within the following ranges:
calcium hydrogen phosphate dihydrate and hydrated silica are used as abrasive of toothpaste, and are replaced by at least one of calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminum hydroxide, etc.
Glycerin and sorbitol are used as toothpaste humectant and are replaced by propylene glycol and the like.
Saccharin sodium is sweetener, and is replaced by xylitol.
The above embodiments can achieve the effects of the following experimental examples:
the compound preparation can effectively inhibit dental plaque, and the Q-H plaque index Mean plus or minus SD is obviously reduced after being used for one week; gingivitis is improved, and the gingival index Mean plus or minus SD is effectively improved along with the increase of the using time; the majority of subjects had symptomatic relief of halitosis and canker sores.
The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims and their equivalents.
Claims (6)
1. The toothpaste for balancing oral micro-ecology is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine;
the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, wherein the molecular weight of the carboxymethyl chitin is 2-5 ten thousand, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is (11-16): 5-9: 0.5 to 0.9;
the preparation method of the American ginseng extract comprises the following steps: extracting radix Panacis Quinquefolii to obtain saponin, drying, pulverizing, adding appropriate amount of aqueous solution containing ammonium sulfate and dipotassium hydrogen phosphate, mixing, sterilizing, inoculating mixed zymocyte seed solution of Aspergillus niger and Bacillus subtilis, fermenting for 20 days, terminating fermentation, and sterilizing.
2. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: the preparation method of the propolis extract comprises the following steps: adding crude propolis into 7 times of boiling water, stirring for 3 hr, cooling to 22-25 deg.C, and removing wax layer and water layer to obtain wax-removed propolis; taking wax-removed propolis, leaching with 8 times of 70% ethanol at constant temperature of 60 deg.C for 3 times, each time for 2 hr, mixing 3 times of leaching solutions, and mixing the leaching solutions according to the weight ratio of propolis leaching solution: preparing the propolis extract according to the water mass ratio of 1: 10.
3. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: and 0.01-0.1 part of saccharin sodium.
4. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: also comprises 0.05-0.5 part of preservative.
5. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: also comprises 0.01 to 0.05 portion of essence.
6. A toothpaste for balancing the oral micro-ecology according to any one of claims 1 to 5, wherein: the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 11: 5: 0.5.
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| Application Number | Priority Date | Filing Date | Title |
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| CN107320428B true CN107320428B (en) | 2020-07-28 |
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| CN102283794B (en) * | 2011-08-22 | 2013-07-24 | 昆明振华制药厂有限公司 | Toothpaste including radix notoginseng and propolis and preparation method thereof |
| CN104013657B (en) * | 2014-01-16 | 2017-08-04 | 金日制药（中国）有限公司 | A kind of American ginseng medicine extracts after saponin(e microbial fermentation extracting method again |
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