CN115721594B - Toothpaste containing ginkgo extract and preparation method thereof - Google Patents
Toothpaste containing ginkgo extract and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a toothpaste containing ginkgo extract, which comprises a preparation method thereof; the invention belongs to the technical field of toothpaste, and particularly relates to a toothpaste containing ginkgo extract and a preparation method thereof; the toothpaste comprises the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of friction agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of PH regulator and the balance of deionized water. According to the invention, by proposing that the traditional Chinese medicine compound auxiliary agent and the ginkgo leaf extract produce a synergistic effect, flavonoid glycosides, ginkgolic acids, ginkgo lactones, polyisoprene and polysaccharide in the ginkgo leaf can more effectively play roles; the invention uses the adsorption resin separation method to extract ginkgo leaves, which can greatly improve the flavone content and obtain the extract with high purity; the invention provides the toothpaste which can efficiently resist inflammation, reduce blood viscosity, improve microcirculation, resist tumors and whiten and clean.
Description
Technical Field
The invention belongs to the technical field of toothpaste, and particularly relates to a toothpaste containing ginkgo extract and a preparation method thereof.
Background
Ginkgo biloba is a plant of the family Ginkgo, the genus Ginkgo, is a fast-growing precious tree species, the folium Ginkgo extract has certain antibacterial and antibacterial adhesion resisting effects in oral cavity, and has effects of enhancing immunity and promoting tumor cell apoptosis, has certain curative effect on oral cancer, and can inhibit carcinogenesis of nitrosamine.
Toothpaste is a common oral care product for people, and has the basic functions of freshening breath, keeping oral health and protecting teeth; in addition, the functional toothpaste with specific effects has the functions of inhibiting dental plaque growth, reducing the dental plaque growth, preventing dental caries, slowing down further deterioration of the generated dental caries, resisting dentin hypersensitiveness, improving tooth discoloration, brightening and whitening and protecting dental enamel; toothpaste is a paste-like substance, and comprises main components of friction agent, humectant, thickener, foaming agent, aromatic, water and other additives; with the continuous improvement and development of the science and technology, the continuous improvement and perfection of the technology and equipment, various toothpastes are continuously developed, the quality and grade of the product are also continuously improved, and certain problems still exist, such as the patent number CN103083212A proposes a red sage root toothpaste which is mainly prepared from the following raw materials: 8-12 parts of red sage root extract, 2-4 parts of dangshen extract, 2-4 parts of ginkgo leaf extract, 2-4 parts of lotus leaf extract, 2-4 parts of polygonum multiflorum extract, 2-4 parts of curcuma aromatica extract and 68-82 parts of toothpaste matrix, which have certain effects on preventing and treating cardiovascular diseases, but only decolorization treatment is carried out after the concentration of the extract, so that the efficiency is low, the impurity content is high, the loss of active ingredients is serious, and the invention does not study the aspects of whitening, anti-inflammatory and the like; the invention provides the toothpaste containing the ginkgo extract, which effectively brushes stains on teeth, has obvious effects of diminishing inflammation, stopping bleeding and repairing dental ulcers, has good prevention and treatment effects on periodontitis, gingivitis, caries prevention, oral cavity peculiar smell and other oral and dental diseases, and simultaneously provides a high-efficiency preparation method.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention provides the toothpaste containing the ginkgo leaf extract and the preparation method thereof, and the invention provides the toothpaste which takes the ginkgo leaf extract as an effective component and takes the traditional Chinese medicine compound as an auxiliary agent, so that the ginkgo leaf extract and the traditional Chinese medicine compound produce synergistic effect, and flavonoid glycosides, ginkgolic acids, bilobalide, polyisoprene and polysaccharide in the ginkgo leaf can more effectively play roles; meanwhile, the ginkgo leaves are extracted by an adsorption resin separation method, so that the flavone content can be greatly improved, and a high-purity extract is obtained; in summary, the invention provides the toothpaste which can efficiently resist inflammation, reduce blood viscosity, improve microcirculation, resist tumors and whiten and clean.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: the invention provides a ginkgo extract-containing toothpaste and a preparation method thereof, wherein the toothpaste comprises the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of friction agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of PH regulator and the balance of deionized water.
Preferably, the toothpaste comprises the following components in parts by weight: 60-80 parts of ginkgo leaf extract, 15-20 parts of traditional Chinese medicine compound auxiliary agent, 15-20 parts of friction agent, 2-8 parts of foaming agent, 10-15 parts of humectant, 3-6 parts of thickening agent, 0.1-2 parts of essence, 0.1-2 parts of preservative, 2-5 parts of PH regulator and the balance of deionized water.
Further, the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 1-10 parts of wampee pit extract, 2-8 parts of alangium root extract, 2-9 parts of horseshoe gold extract, 1-8 parts of herba orostachyos extract and 3-15 parts of Chinese peach leaf extract.
Preferably, the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 2-8 parts of wampee pit extract, 3-5 parts of alangium root extract, 3-8 parts of horseshoe gold extract, 2-6 parts of herba orostachyos extract and 4-10 parts of Chinese peach leaf extract.
Further, the friction agent comprises one or more combinations of friction silica, dibasic calcium phosphate dihydrate.
Further, the foaming agent comprises one or more of sodium dodecyl sulfate, cocamidopropyl betaine or sodium lauroyl sarcosinate; the humectant comprises one or more of sorbitol, glycerol and propylene glycol; the thickener comprises one or more of sodium carboxymethyl cellulose and silicon dioxide; the essence comprises one or more of lemon oil, spearmint oil, orange oil, tangerine oil, wintergreen oil, clove oil and cinnamon oil; the preservative comprises one or more of triclosan, methyl benzoate, ethyl benzoate and sodium benzoate; the PH regulator is one or a combination of more of citric acid, sodium dihydrogen phosphate and disodium hydrogen phosphate.
The invention also provides a preparation method of the toothpaste containing the ginkgo extract, which comprises the following steps:
(1) Pulverizing folium Ginkgo, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate;
(2) Separating the filtrate with adsorption resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, drying, pulverizing to obtain 180 mesh dispersed fine powder, and making into dry ginkgo extract powder;
(3) Mixing wampee pit, alangium chinense leaf, herba Calthae, herba Loranthi, and fructus Persicae, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate; adding 10 times of water into the residues after ethanol extraction, decocting for 2 times each for 1 hour, mixing decoctions, filtering with 200 mesh stainless steel mesh, and concentrating the filtrate into Chinese medicinal compound extract with relative density of 1.10;
(4) Adding deionized water into the ginkgo dry extract powder and the traditional Chinese medicine compound extract, adding an abrasive, a foaming agent, a humectant, a thickener, essence and a preservative, adjusting the PH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring in vacuum for 10-25 minutes to obtain the toothpaste.
The beneficial effects obtained by the invention by adopting the structure are as follows:
according to the invention, by proposing that the traditional Chinese medicine compound auxiliary agent and the ginkgo leaf extract produce a synergistic effect, flavonoid glycosides, ginkgolic acids, ginkgo lactones, polyisoprene and polysaccharide in the ginkgo leaf can more effectively play roles; the ginkgo leaf is extracted by an adsorption resin separation method, so that the flavone content can be greatly improved, and a high-purity extract is obtained; the invention provides the toothpaste which can efficiently resist inflammation, reduce blood viscosity, improve microcirculation, resist tumors and whiten and clean.
The invention takes ginkgo leaf extract and traditional Chinese medicine compound auxiliary agent as main active ingredients to realize the effects of anti-inflammatory, whitening and the like of toothpaste.
The ginkgo leaf has high medicinal value, flat property, bitter, sweet and astringent taste, good effects of heart and spleen astringing, dampness eliminating and diarrhea stopping and the like, and the active ingredients of the ginkgo leaf have good prevention and treatment effects on daily nursing of the oral cavity; the wampee fruit core is the seed of dicotyledon medicine rue skin, has Xin Wei bitter taste, is warm in nature and nontoxic, and can remove accumulation and detumescence; the Alangium chinense leaf is leaf of Alangium chinense of Alangiaceae, has pungent and bitter properties, and can detoxify, detumescence, remove blood stasis and relieve pain; the herba Zosterae Marinae whole herb is used for treating drug, and has effects of clearing heat, promoting urination, dispelling pathogenic wind, relieving pain, stopping bleeding, promoting granulation, diminishing inflammation, removing toxic substances, and killing parasite; can be used for treating acute and chronic hepatitis, renal tonsillitis, stomatitis, etc., and has soft texture of spindle Luo Caoshe, high edibility, bitter taste, cold property, and effects of dispelling pathogenic wind and cold, detumescence, and relieving cough; han Guo leaves can promote qi circulation to relieve pain, promote blood circulation to alleviate swelling.
Drawings
FIG. 1 shows the bactericidal effect of a toothpaste containing ginkgo extract on oral cavity;
FIG. 2 shows the effect of a ginkgo extract-containing toothpaste according to the present invention on colony count;
fig. 3 shows the results of determining the detergency value of a toothpaste containing ginkgo extract according to the present invention.
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention; all other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the present invention. The preferred methods and materials described herein are illustrative only and should not be construed as limiting the scope of the present application.
The experimental methods in the following examples are all conventional methods unless otherwise specified; the test materials and test strains used in the examples described below, unless otherwise specified, were commercially available.
Example 1
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 60 parts of ginkgo leaf extract, 15 parts of traditional Chinese medicine compound auxiliary agent, 15 parts of friction agent, 2 parts of foaming agent, 10 parts of humectant, 3 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 2 parts of PH regulator and the balance of deionized water.
Wherein, the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 4 parts of wampee pit extract, 4 parts of Chinese alangium root extract, 3 parts of horseshoe gold extract, 5 parts of herba orostachyos extract and 8 parts of Chinese peach leaf extract.
Wherein the friction agent is friction type silicon dioxide; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickener is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the PH regulator is citric acid and sodium dihydrogen phosphate.
The invention also provides a preparation method of the toothpaste containing the ginkgo extract, which comprises the following steps:
(1) Pulverizing folium Ginkgo, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate;
(2) Separating the filtrate with adsorption resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, drying, pulverizing to obtain 180 mesh dispersed fine powder, and making into dry ginkgo extract powder;
(3) Mixing wampee pit, alangium chinense leaf, herba Calthae, herba Loranthi, and fructus Persicae, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate; adding 10 times of water into the residues after ethanol extraction, decocting for 2 times each for 1 hour, mixing decoctions, filtering with 200 mesh stainless steel mesh, and concentrating the filtrate into Chinese medicinal compound extract with relative density of 1.10;
(4) Adding deionized water into the ginkgo dry extract powder and the traditional Chinese medicine compound extract, adding an abrasive, a foaming agent, a humectant, a thickener, essence and a preservative, adjusting the PH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring in vacuum for 10-25 minutes to obtain the toothpaste.
Example 2
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 70 parts of ginkgo leaf extract, 18 parts of traditional Chinese medicine compound auxiliary agent, 15 parts of friction agent, 4 parts of foaming agent, 10 parts of humectant, 3 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 3 parts of PH regulator and the balance of deionized water.
Wherein, the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 4 parts of wampee pit extract, 4 parts of Chinese alangium root extract, 3 parts of horseshoe gold extract, 5 parts of herba orostachyos extract and 8 parts of Chinese peach leaf extract.
Wherein the friction agent is friction type silicon dioxide; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickener is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the PH regulator is citric acid and sodium dihydrogen phosphate.
In addition, the invention also provides a toothpaste containing ginkgo extract and a preparation method thereof, wherein the preparation method is implemented by referring to the embodiment 1.
Example 3
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 80 parts of ginkgo leaf extract, 20 parts of traditional Chinese medicine compound auxiliary agent, 16 parts of friction agent, 6 parts of foaming agent, 12 parts of humectant, 5 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 3 parts of PH regulator and the balance of deionized water.
Wherein, the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 4 parts of wampee pit extract, 4 parts of Chinese alangium root extract, 3 parts of horseshoe gold extract, 5 parts of herba orostachyos extract and 8 parts of Chinese peach leaf extract.
Wherein the friction agent is friction type silicon dioxide; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickener is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the PH regulator is citric acid and sodium dihydrogen phosphate.
In addition, the invention also provides a toothpaste containing ginkgo extract and a preparation method thereof, wherein the preparation method is implemented by referring to the embodiment 1.
Comparative example 1
This comparative example provides a toothpaste containing ginkgo extract and a preparation method thereof, which are different from example 1 only in that all components do not contain traditional Chinese medicine compound auxiliaries, and the contents of the rest components and components are the same as those of example 1.
Experimental example 1
A toothpaste containing semen Ginkgo extract for sterilizing oral cavity
The toothpastes of examples 1, 2, 3 and comparative example 1 were subjected to oral sterilization test, and a total of 80 patients with oral health were randomly divided into 4 groups of 20 toothbrushing each day using the toothpastes of examples 1, 2, 3 and comparative example 1, once a day, five minutes each time, and the sterilization rate of the different groups of toothpastes to the oral cavity was calculated on the seventh day.
Collecting saliva of different volunteers, diluting with sterile PBS, respectively coating 0.2mL on BHIA plates, anaerobically culturing at 37deg.C for 72h, eluting BHIA plates with 2mL sterile PBS solution, and collecting eluate as oral bacteria solution for testing; respectively measuring 75mL of sterile PBS and 25g of sample (25 mL of BS solution for blank group and toothpaste with different formulas for experimental group), sucking 9mL of slurry, and adding into a test tube for standby; diluting the eluent to a concentration of 1X 106CFU/mL by using sterile PBS; 1.0mL of bacterial suspension is sucked and added into 9mL of serous fluid for standby, the mixed solution is sucked and properly diluted after 2min, and bacterial counting is carried out after anaerobic culture for 72 h. The calculation formula is as follows: sterilization rate= (average colony count of blank group-average colony count of experimental group)/average colony count of blank group x 100%.
As shown in figure 1, the toothpaste of the embodiment 3 prepared by the invention has good sterilization effect, the sterilization rate can reach 98.47%, the sterilization effects of the embodiment 2 and the embodiment 1 are inferior, and the sterilization rate of the comparative example 1 is 16.67% at the minimum; as shown in fig. 2, a is the colony count of the toothpaste of comparative example 1 at day 3; b is the colony count of the toothpaste of example 1; c is the colony count of the toothpaste of example 2; d is the number of colonies for the toothpaste of example 3, the number of colonies in example 3 is the least, the number of colonies in comparative example 1 is the most, and examples 1 and 2 are in intermediate positions.
Experimental example 2
A toothpaste containing semen Ginkgo extract for treating stomatocace
Oral clinical tests were performed on the toothpastes of examples 1, 2, 3 and comparative example 1 for a total of 80 patients with recurrent oral ulcers, and all with symptoms of swelling and pain of gums and bleeding of gums; 80 volunteers were randomly divided into 4 groups of 20 each, and were brushed daily using the toothpastes of examples 1, 2, 3 and comparative example 1, once a day, five minutes each, for 2 months.
The result analysis shows that the toothpaste of the formula of the example 3 has obvious effect on patients suffering from canker sore, the obvious rate reaches 80%, the effective rate is 100%, and the gingival bleeding and swelling and pain of the patients are eliminated or slowed down to a certain extent; the toothpaste of the formula of comparative example 1 has no obvious effect on patients suffering from canker sore, and the effective rate is only 5%.
TABLE 1 Effect of toothpaste containing Ginkgo biloba extract on patients with canker sore
Experimental example 3
Cleanliness test of toothpaste containing ginkgo extract
A piece of white ceramic plate subjected to multiple soaking and drying treatments of concentrated tea was prepared, and the white ceramic plate was equally divided into 4 areas by a corrected whiteness meter, and was brushed 10 times with the toothpastes of examples 1, 2, 3 and comparative example 1, respectively, after rinsing with clear water, the difference in whiteness before and after rinsing was compared, and the decontamination value was calculated, and the decontamination value = whiteness after brushing-whiteness before brushing.
As a result, as shown in FIG. 3, the toothpaste of example 3 of the present invention had a stain removal value of up to 61.58, example 2 had a stain removal value of 47.97, example 1 had a stain removal value of 40.97, and comparative example 1 had a stain removal value of at least 10.5.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The invention and its embodiments have been described above with no limitation, and the actual construction is not limited to the embodiments of the invention as shown in the drawings. In summary, if one of ordinary skill in the art is informed by this disclosure, a structural manner and an embodiment similar to the technical solution should not be creatively devised without departing from the gist of the present invention.
Claims (4)
1. A toothpaste containing ginkgo extract, which is characterized in that: the toothpaste consists of the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of friction agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of PH regulator and the balance of deionized water;
the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 1-10 parts of wampee pit extract, 2-8 parts of alangium root extract, 2-9 parts of horseshoe gold extract, 1-8 parts of herba orostachyos extract and 3-15 parts of Chinese peach leaf extract;
the friction agent is selected from one or more of friction silicon dioxide and calcium hydrophosphate dihydrate;
the foaming agent is selected from one or more of sodium dodecyl sulfate, cocamidopropyl betaine or sodium dodecyl sarcosinate;
the humectant is one or more of sorbitol, glycerol and propylene glycol;
the thickener is one or a combination of more of sodium carboxymethyl cellulose and silicon dioxide;
the essence is one or more selected from lemon oil, spearmint oil, orange oil, tangerine oil, wintergreen oil, clove oil and cinnamon oil;
the preservative is one or a combination of more of triclosan, methyl benzoate, ethyl benzoate and sodium benzoate;
the pH regulator is one or more selected from citric acid, sodium dihydrogen phosphate and disodium hydrogen phosphate.
2. A toothpaste comprising ginkgo extract according to claim 1, wherein: the toothpaste consists of the following components in parts by weight: 60-80 parts of ginkgo leaf extract, 15-20 parts of traditional Chinese medicine compound auxiliary agent, 15-20 parts of friction agent, 2-8 parts of foaming agent, 10-15 parts of humectant, 3-6 parts of thickening agent, 0.1-2 parts of essence, 0.1-2 parts of preservative, 2-5 parts of PH regulator and the balance of deionized water.
3. A toothpaste comprising ginkgo extract according to claim 2, wherein: the traditional Chinese medicine compound auxiliary agent comprises the following components in parts by weight: 2-8 parts of wampee pit extract, 3-5 parts of alangium root extract, 3-8 parts of horseshoe gold extract, 2-6 parts of herba orostachyos extract and 4-10 parts of Chinese peach leaf extract.
4. A process for preparing a toothpaste comprising ginkgo extract according to any one of claims 1 to 3, characterized in that: the method specifically comprises the following steps:
(1) Pulverizing folium Ginkgo, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate;
(2) Separating the filtrate with adsorption resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, drying, pulverizing to obtain 180 mesh dispersed fine powder, and making into dry ginkgo extract powder;
(3) Mixing wampee kernel, alangium chinense leaves, herba Calthae Calycarpa leaves, herba Thymi vulgaris and fructus Persicae leaves, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice for 2 hours each time, mixing the alcohol extract, filtering through a 200-mesh stainless steel screen, and reserving the filtrate; adding 10 times of water into the residues after ethanol extraction, decocting for 2 times each for 1 hour, mixing decoctions, filtering with 200 mesh stainless steel mesh, and concentrating the filtrate into Chinese medicinal compound extract with relative density of 1.10;
(4) Adding deionized water into the ginkgo dry extract powder and the traditional Chinese medicine compound extract, adding an abrasive, a foaming agent, a humectant, a thickener, essence and a preservative, adjusting the PH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring in vacuum for 10-25 minutes to obtain the toothpaste.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267129A (en) * | 2015-11-25 | 2016-01-27 | 王晓伟 | Ginkgo leaf stain-removing toothpaste |
| CN105476919A (en) * | 2015-12-24 | 2016-04-13 | 青岛克立克信息技术有限公司 | Chinese medicinal toothpaste |
| CN108113915A (en) * | 2016-11-29 | 2018-06-05 | 房世俊 | A kind of Allergy-free toothpaste and preparation method thereof |
| CN110339107A (en) * | 2019-07-03 | 2019-10-18 | 安徽科技学院 | A kind of schefflera arboricola gum analgesic health-care toothpaste and preparation method thereof |
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- 2022-12-17 CN CN202211626050.1A patent/CN115721594B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267129A (en) * | 2015-11-25 | 2016-01-27 | 王晓伟 | Ginkgo leaf stain-removing toothpaste |
| CN105476919A (en) * | 2015-12-24 | 2016-04-13 | 青岛克立克信息技术有限公司 | Chinese medicinal toothpaste |
| CN108113915A (en) * | 2016-11-29 | 2018-06-05 | 房世俊 | A kind of Allergy-free toothpaste and preparation method thereof |
| CN110339107A (en) * | 2019-07-03 | 2019-10-18 | 安徽科技学院 | A kind of schefflera arboricola gum analgesic health-care toothpaste and preparation method thereof |
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