CN115364016B - Toothpaste with periodontal disease improving effect and preparation method thereof - Google Patents
Toothpaste with periodontal disease improving effect and preparation method thereof Download PDFInfo
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- CN115364016B CN115364016B CN202211186169.1A CN202211186169A CN115364016B CN 115364016 B CN115364016 B CN 115364016B CN 202211186169 A CN202211186169 A CN 202211186169A CN 115364016 B CN115364016 B CN 115364016B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses toothpaste with a periodontal disease improving effect and a preparation method thereof, wherein the toothpaste comprises the following components in parts by weight: 0.2 to 0.8 part of tartary buckwheat rutin, 0.5 to 1.0 part of tea polyphenol, 1 to 3 parts of honeysuckle extract, 0.5 to 1 part of licorice extract, 40 to 60 parts of humectant, 2 to 4 parts of surfactant, 3 to 5 parts of thickener, 15 to 20 parts of friction agent, 1 to 2 parts of sweetener, 0.5 to 1.5 parts of titanium dioxide, 1 to 2 parts of essence and 10 to 25 parts of water; the toothpaste can effectively inhibit pathogenic bacteria of periodontal disease, promote periodontal tissue injury repair, relieve and alleviate gingival red swelling and bleeding, and effectively improve periodontal disease, and finally achieve periodontal disease treatment purpose.
Description
Technical Field
The invention relates to the technical field of toothpaste preparation, in particular to toothpaste with a periodontal disease improving effect and a preparation method thereof.
Background
Gingivitis is an early, reversible inflammatory disorder of the gingival tissue, which is a periodontal disease. Gingivitis may occur if bleeding occurs during brushing or if a brush is found to be stained with blood. In addition, if the teeth are found to be stained with blood when biting hard objects such as apples or steamed bread, inflammation of gums may also be demonstrated. Since gingivitis is reversible, plaque and plaque on the teeth can be removed by effective brushing or clinical rinsing, thereby restoring the gums. Clinically, the most common oral diseases are caries and periodontal disease, which in turn includes gingivitis and periodontitis.
At present, most of the existing toothpastes are used for removing stains and improving the brightness of teeth, and few toothpastes have the efficacy of removing stains and improving periodontal diseases, so that it is particularly critical to provide a toothpaste with excellent efficacy of improving periodontal diseases.
Disclosure of Invention
The invention aims to provide the toothpaste with the effect of improving the periodontal disease and the preparation method thereof, and the toothpaste can effectively inhibit pathogenic bacteria of the periodontal disease, relieve and alleviate the problems of gum redness, bleeding and the like, effectively improve periodontal disease symptoms and has remarkable effect.
In order to achieve the above object of the present invention, the following technical solutions are specifically adopted:
the invention provides toothpaste with the efficacy of improving periodontal disease, which comprises the following components in parts by weight:
0.2 to 0.8 part of tartary buckwheat rutin, 0.5 to 1.0 part of tea polyphenol, 1 to 3 parts of honeysuckle extract, 0.5 to 1 part of licorice extract, 40 to 60 parts of humectant, 2 to 4 parts of surfactant, 3 to 5 parts of thickener, 15 to 20 parts of friction agent, 1 to 2 parts of sweetener, 0.5 to 1.5 parts of titanium dioxide, 1 to 2 parts of essence and 10 to 25 parts of water.
Preferably, the toothpaste comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of licorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water.
Preferably, the humectant is sorbitol and/or polyethylene glycol.
Preferably, the surfactant is sodium dodecyl sulfate and/or sodium lauryl sulfate.
Preferably, the thickener is at least one of xanthan gum, hydroxyethyl cellulose, and carbopol resin.
Preferably, the abrasive is calcium carbonate or hydrated silica.
Preferably, the sweetener is sodium saccharin or erythritol.
Preferably, the honeysuckle extract and the licorice extract are water extracts.
The second aspect of the present invention provides a method for preparing the above toothpaste, comprising the steps of:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Compared with the prior art, the invention has the beneficial effects that at least:
according to the toothpaste, the tartary buckwheat rutin is adopted to improve microcirculation of periodontal tissues, and the tea polyphenol and the honeysuckle extract are cooperated to achieve excellent antibacterial and anti-inflammatory effects, and the liquorice is used for improving cell activity in the periodontal tissues and harmonizing the effects of the components, so that pathogenic bacteria of periodontal diseases are effectively inhibited through combined action of the components, periodontal tissue injury repair is promoted, the problems of gum redness, swelling, bleeding and the like are relieved, periodontal disease symptoms are effectively improved, and finally the purpose of periodontal disease treatment is achieved.
Detailed Description
Embodiments of the technical scheme of the present invention will be described in detail below with reference to the embodiments. The following examples are only for more clearly illustrating the technical aspects of the present invention, and thus are merely examples, and are not intended to limit the scope of the present invention.
It is noted that unless otherwise indicated, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.
The following examples used the following raw materials:
the tartary buckwheat rutin is prepared by the following steps:
(a) Selecting fresh tartary buckwheat flowers in a flowering period, and performing freeze grinding on the tartary buckwheat flowers for 0.2h to obtain tartary buckwheat powder;
(b) Under the ultrasonic condition of 600W, according to the mass ratio of the tartary buckwheat powder to the extracting solution of 1:10, placing the tartary buckwheat powder into the extracting solution with the pH value of 8.8, extracting for 0.5h at room temperature, and filtering to obtain the tartary buckwheat extracting solution, wherein the extracting solution comprises the following components: ethanol, sodium sulfite and water; the volume concentration of ethanol in the extracting solution is 60 percent, and the mass concentration of sodium sulfite is 0.2 percent;
(c) Regulating the pH value of the tartary buckwheat extracting solution to 3.5, standing for 5 hours, and filtering to obtain a tartary buckwheat rutin crude product;
(d) Washing the crude product of the tartary buckwheat rutin with water and drying in vacuum to obtain the tartary buckwheat rutin.
Honeysuckle water extract: are commonly and commercially available;
tea polyphenols: are commonly and commercially available;
aqueous licorice extract: are commercially available in general.
Example 1
1. Toothpaste with periodontal disease improving effect
The toothpaste with the periodontal disease improving effect comprises the following components in parts by weight:
0.2 part of tartary buckwheat rutin, 1.0 part of tea polyphenol, 3 parts of honeysuckle extract, 0.5 part of licorice extract, 40 parts of humectant, 2 parts of surfactant, 5 parts of thickener, 20 parts of friction agent, 1 part of sweetener, 1.5 parts of titanium dioxide, 2 parts of essence and 25 parts of water;
wherein the humectant is polyethylene glycol;
the surfactant is sodium dodecyl sulfate;
the thickener is carbomer resin;
the friction agent is calcium carbonate;
the sweetener is saccharin sodium;
2. preparation method
The preparation method of the toothpaste with the periodontal disease improving effect comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Example 2
1. Toothpaste with periodontal disease improving effect
The toothpaste with the periodontal disease improving effect comprises the following components in parts by weight:
0.8 part of tartary buckwheat rutin, 0.5 part of tea polyphenol, 1 part of honeysuckle extract, 1 part of licorice extract, 60 parts of humectant, 4 parts of surfactant, 3 parts of thickener, 15 parts of friction agent, 2 parts of sweetener, 0.5 part of titanium dioxide, 1 part of essence and 10 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickener is xanthan gum;
the friction agent is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the periodontal disease improving effect comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Example 3
1. Toothpaste with periodontal disease improving effect
The toothpaste with the periodontal disease improving effect comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of licorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickener is hydroxyethyl cellulose;
the friction agent is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the periodontal disease improving effect comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Comparative example 1
1. Toothpaste with periodontal disease improving effect
The toothpaste with the periodontal disease improving effect comprises the following components in parts by weight:
1.3 parts of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of licorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickener is hydroxyethyl cellulose;
the friction agent is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the periodontal disease improving effect comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Comparative example 2
1. Toothpaste with periodontal disease improving effect
The toothpaste with the periodontal disease improving effect comprises the following components in parts by weight:
1.3 parts of tartary buckwheat rutin, 2 parts of honeysuckle extract, 0.8 part of licorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water;
wherein the humectant is sorbitol;
the surfactant is sodium lauryl sulfate;
the thickener is hydroxyethyl cellulose;
the friction agent is hydrated silica;
the sweetener is erythritol;
2. preparation method
The preparation method of the toothpaste with the periodontal disease improving effect comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
Experimental example
90 patients with gingivitis are selected, the ages of the patients are 8-24 years, 42 men and 38 women are treated with gingivitis within 3 weeks; randomly dividing into 3 groups of 30 persons each, wherein the first group uses the toothpaste prepared in the example 3 to brush teeth, the second group uses the toothpaste prepared in the comparative example 1 to brush teeth, and the third group uses the toothpaste prepared in the comparative example 2 to brush teeth once in the morning and at night, each time is not less than 3 minutes, and a uniform toothbrush is adopted; treatment with no other drugs was performed during the experiment; brushing teeth continuously for 20 days;
the gum index and plaque index of each patient before and after brushing with the toothpastes of examples and comparative examples were measured according to the Loe-silness standard, and the measurement results are shown in table 1:
TABLE 1 gingival index and plaque index before and after treatment of different groups
As can be seen from table 1:
the toothpaste prepared by the embodiment of the invention and the comparative example has the effect of improving gingivitis, however, compared with the comparative example, the toothpaste prepared by the invention has more excellent treatment effect.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention, and are intended to be included within the scope of the appended claims and description.
Claims (9)
1. A toothpaste with periodontal disease improving effect, which is characterized by comprising the following components in parts by weight:
0.2 to 0.8 part of tartary buckwheat rutin, 0.5 to 1.0 part of tea polyphenol, 1 to 3 parts of honeysuckle extract, 0.5 to 1 part of licorice extract, 40 to 60 parts of humectant, 2 to 4 parts of surfactant, 3 to 5 parts of thickener, 15 to 20 parts of friction agent, 1 to 2 parts of sweetener, 0.5 to 1.5 parts of titanium dioxide, 1 to 2 parts of essence and 10 to 25 parts of water.
2. The toothpaste according to claim 1, wherein the toothpaste comprises the following components in parts by weight:
0.5 part of tartary buckwheat rutin, 0.8 part of tea polyphenol, 2 parts of honeysuckle extract, 0.8 part of licorice extract, 50 parts of humectant, 3 parts of surfactant, 4 parts of thickener, 18 parts of friction agent, 1.5 parts of sweetener, 1 part of titanium dioxide, 1.4 parts of essence and 17 parts of water.
3. The toothpaste according to claim 1, wherein the humectant is sorbitol and/or polyethylene glycol.
4. The toothpaste according to claim 1, wherein the surfactant is sodium dodecyl sulfate and/or sodium lauryl sulfate.
5. The toothpaste of claim 1, wherein the thickening agent is at least one of xanthan gum, hydroxyethyl cellulose, and carbopol resin.
6. The toothpaste of claim 1, wherein the abrasive is calcium carbonate or hydrated silica.
7. The toothpaste of claim 1, wherein the sweetener is sodium saccharin or erythritol.
8. The toothpaste of claim 1, wherein the honeysuckle extract and licorice extract are aqueous extracts.
9. A method of preparing a toothpaste according to any one of claims 1 to 8, comprising the steps of:
(a) Weighing the components according to the weight parts;
(b) Mixing the above materials, stirring to obtain paste, and packaging.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211186169.1A CN115364016B (en) | 2022-09-27 | 2022-09-27 | Toothpaste with periodontal disease improving effect and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211186169.1A CN115364016B (en) | 2022-09-27 | 2022-09-27 | Toothpaste with periodontal disease improving effect and preparation method thereof |
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| CN115364016A CN115364016A (en) | 2022-11-22 |
| CN115364016B true CN115364016B (en) | 2023-07-25 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003039452A2 (en) * | 2001-11-06 | 2003-05-15 | The Quigley Corporation | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| CN103083209A (en) * | 2013-01-25 | 2013-05-08 | 中山大学 | Master slice for mouthwash and preparation method thereof |
| CN107929173A (en) * | 2017-12-29 | 2018-04-20 | 南宁圣特生物科技有限公司 | Buckwheat Chinese mugwort tea seed essential oil and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110256072A1 (en) * | 2008-11-28 | 2011-10-20 | Ezaki Glico Co., Ltd. | Food and composition each comprising phosphorylated saccharide, polyphenol and fluoride |
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- 2022-09-27 CN CN202211186169.1A patent/CN115364016B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003039452A2 (en) * | 2001-11-06 | 2003-05-15 | The Quigley Corporation | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| CN103083209A (en) * | 2013-01-25 | 2013-05-08 | 中山大学 | Master slice for mouthwash and preparation method thereof |
| CN107929173A (en) * | 2017-12-29 | 2018-04-20 | 南宁圣特生物科技有限公司 | Buckwheat Chinese mugwort tea seed essential oil and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 苦荞抗氧化活性研究;李谣;中国酿造;第6卷(第32期);24-27 * |
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