CN113288833B

CN113288833B - A toothpaste containing extract of marrubium vulgare for relieving sensitivity

Info

Publication number: CN113288833B
Application number: CN202110358846.2A
Authority: CN
Inventors: 桑苏君
Original assignee: Beijing Shengyong Pharmaceutical Co ltd
Current assignee: Beijing Shengyong Pharmaceutical Co ltd
Priority date: 2021-04-02
Filing date: 2021-04-02
Publication date: 2022-08-30
Anticipated expiration: 2041-04-02
Also published as: CN113288833A

Abstract

The invention discloses a sensitivity-relieving toothpaste containing an Erysia extract, which comprises the following components: silicon dioxide composition, sorbitol, polyethylene glycol 600, glycerol, hydroxypropyl guar gum, hydroxyethyl cellulose, saccharin sodium, sodium lauryl sulfate, essence, cooling agent, methyl paraben, pigment, marrubium vulgare extract, cymene, thymol, strontium chloride, allantoin, tranexamic acid, potassium chloride, sodium azulene sulfonate and deionized water; according to the invention, the marrubium vulgare extract is added into the formula, so that toxic oxides which damage protein and lipid structures can be removed, cell metabolism is promoted, the adverse state of gum is improved, the sensitivity phenomenon is relieved, and the oral health index is effectively improved. The natural bactericidal component contained in the marrubium vulgare extract can help to inhibit the harm in the oral cavity and promote the balance of oral flora, and the oral cavity has faint scent and fresh breath like bathing forest.

Description

A toothpaste containing marrubium vulgare extract for relieving sensitivity

Technical Field

The invention relates to toothpaste, in particular to toothpaste containing an extract of marrubium vulgare for relieving sensitivity.

Background

Tooth brushing is the most widely used and obvious oral cavity cleaning method at present, and in order to improve the tooth plaque cleaning effect and reduce the abrasion to teeth, people focus on the improvement of the tooth brushing method, and researches dozens of different tooth brushing methods, but the unexpected effect is not achieved, and then people shift the focus of attention to the design of the toothbrush, so that different types of toothbrushes are produced, the ideal effect is not achieved, and the toothpaste is the focus of attention at present. At present, the components of toothpaste can be mainly divided into three types: base material, flavoring agent and functional additive. The raw materials mainly comprise an abrasive, a humectant, a foaming agent, a binder, a spice, a sweetener and the like, wherein the abrasive has the highest content which can sometimes reach more than 50%, is a powdery solid capable of wiping off foreign substances of teeth under slight pressure, is a chemically inert substance, is tasteless, can keep inherent chemical and physical properties in the production and storage processes of the product, is nontoxic and can be normally used, can be mixed with other components in the formula, and is a substance easy to disperse in the oral cavity.

With age, gingival tissue begins to atrophy, causing dentin exposure to cause allergic symptoms of the teeth, resulting in tooth pain. On the other hand, because periodontitis and gingivitis also cause tooth pain, tooth brushing is a basic method for maintaining oral health, and the prevention of periodontal diseases and dental caries requires daily tooth brushing, researches show that the mouth wash can reduce microorganisms in the oral cavity by 15 percent, the tooth brushing can reduce the microorganisms in the oral cavity by 60 percent, the tooth brushing time can be reduced by 20 to 40 percent by using the toothpaste, the removal of dental plaque can be obviously improved by an abrasive in the toothpaste, the higher the content, the particles and the hardness of the abrasive are, the higher the friction force of the toothpaste is, the better the removal effect of the dental plaque is, however, the toothpaste with large friction force can cause tooth abrasion while cleaning teeth, and research shows that the abrasive in the toothpaste increases the abrasion of the toothbrush to the teeth by 1.12 times, however, most toothpaste only studies the cleaning and whitening capability at present, and no attention is paid to the abrasion of teeth.

There is therefore a need for a soothing sensitive toothpaste containing an extract of marrubium vulgare that effectively cleans the oral cavity while reducing the damage to the teeth.

Disclosure of Invention

The present invention aims to provide a toothpaste containing an extract of marrubium vulgare for alleviating sensitivity, so as to solve the problems in the background art.

In order to achieve the purpose, the invention provides the following technical scheme:

a desensitizing toothpaste containing an extract of marrubium vulgare comprises the following ingredients: silicon dioxide composition, sorbitol, polyethylene glycol 600, glycerol, hydroxypropyl guar gum, hydroxyethyl cellulose, saccharin sodium, sodium lauryl sulfate, essence, cooling agent, methyl paraben, pigment, marrubium vulgare extract, cymene, thymol, strontium chloride, allantoin, tranexamic acid, potassium chloride, sodium azulene sulfonate and deionized water.

As a further scheme of the invention: the paint comprises the following components in percentage by mass: silica composition: 15-25%, sorbitol: 40-70%, polyethylene glycol 600: 3-8%, glycerol: 3-8%, hydroxypropyl guar gum: 0.1-2%, hydroxyethyl cellulose: 0.1-2%, saccharin sodium: 0.1-2%, sodium lauryl sulfate: 1-10%, essence: 0.5-2%, cooling agent: 0.01-1%, methyl paraben: 0.01-0.15%, pigment: 0.001-0.01%, marrubium vulgare extract: 0.01-0.5%, cymene: 0.01-0.5%, thymol: 0.01-0.5%, strontium chloride: 0.1-2%, allantoin: 0.1-2%, tranexamic acid: 0.01-0.2%, potassium chloride: 0.1-2%, sodium azulene sulfonate: 0.01-1% and the balance of deionized water.

As a further scheme of the invention: the material consists of the following components in percentage by mass: silica composition: 18.5%, sorbitol: 59%, polyethylene glycol 600: 5%, glycerin: 5%, hydroxypropyl guar gum: 0.4%, hydroxyethyl cellulose: 0.4%, sodium saccharin: 0.25%, sodium lauryl sulfate: 2.4% and essence: 1.1%, cooling agent: 0.05%, methyl paraben: 0.1%, pigment: 0.002%, marrubium vulgare extract: 0.1%, cymene: 0.1%, thymol: 0.03%, strontium chloride: 0.5%, allantoin: 0.2%, tranexamic acid: 0.05%, potassium chloride: 0.5%, sodium azulene sulfonate: 0.01-0.5 percent, and the balance of deionized water.

As a further scheme of the invention: the silica composition comprises a friction silica and a thickening silica, the friction silica having a dentin friction value of less than 130.

As a further scheme of the invention: the proportion of the friction type silicon dioxide to the thickening type silicon dioxide is 1: 2-3.

As a further scheme of the invention: the raw material of the eriocaulon henryi extract is one of eriocaulon henryi leaves, eriocaulon henryi branches, eriocaulon henryi petals and eriocaulon henryi fruits;

or a mixture of the leaf blades and the branches of the marrubium vulgare in a ratio of 5: 2;

or a mixture of leaf blades, branches and petals of the European summer solstice according to a ratio of 7:2: 1;

or a mixture of the leaf of the European summer solstice, the branch of the European summer solstice, the petal of the European summer solstice and the fruit of the European summer solstice in a ratio of 15:3:2: 2.

As a further scheme of the invention: the preparation method of the marrubium vulgare extract comprises the following steps:

a, weighing raw materials in required parts by weight, washing, removing chlorophyll by using chloroform, washing again, and drying to obtain dried raw materials;

b, crushing the dried raw material to obtain powder;

and C, leaching the powder by using ethanol with the weight part 8-10 times that of the powder, wherein the leaching times are 2-5 times.

As a further scheme of the invention: the water content of the dried raw material in the step A is less than 5%.

As a further scheme of the invention: and the particle diameter of the powder in the step B is less than 200 meshes.

As a still further scheme of the invention: and the concentration of the ethanol in the step C is 65-75%.

Compared with the prior art, the invention has the beneficial effects that:

according to the invention, the marrubium vulgare extract is added into the formula, so that toxic oxides which damage protein and lipid structures can be removed, cell metabolism is promoted, the bad state of gum is improved, the sensitive phenomenon is relieved, and the oral health index is effectively improved. The natural bactericidal component contained in the marrubium vulgare extract can help to inhibit the harm in the oral cavity and promote the balance of oral flora, and the oral cavity has faint scent and fresh breath like bathing forest.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention will be further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used merely to facilitate describing the invention and to simplify the description, and do not indicate or imply that the referenced devices or elements must be constructed and operated in a particular orientation within the specification and are not to be considered limiting of the invention.

Furthermore, the terms "first", "second", "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

In the invention, the toothpaste containing the marrubium vulgare extract for relieving sensitivity comprises the following components: silicon dioxide composition, sorbitol, polyethylene glycol 600, glycerol, hydroxypropyl guar gum, hydroxyethyl cellulose, saccharin sodium, sodium lauryl sulfate, essence, cooling agent, methyl paraben, pigment, marrubium vulgare extract, cymene, thymol, strontium chloride, allantoin, tranexamic acid, potassium chloride, sodium azulene sulfonate and deionized water.

Sodium saccharin as a sweetener can cause sweet reaction in taste, but does not contain sugar, so that the sodium saccharin should be added into toothpaste to improve the taste of the toothpaste and avoid adverse effects on diabetics.

Allantoin, also known as N- (2, 5-dioxo-4-imidazolidinyl) urea, has a molecular formula of C4H6N4O3, is a hydantoin derivative, has a good bactericidal effect, can kill harmful bacteria in the oral cavity when being used as a toothpaste preservative, and has physiological functions of promoting cell growth, accelerating wound healing, softening keratin and the like.

The sodium azulene sulfonate is an anti-inflammatory and anti-ulcer medicine with little side effect, has good treatment effect on common oral diseases, and can effectively eliminate symptoms such as edema, hyperemia, abscess, gingival bleeding, halitosis, odontoseisis and the like caused by the common oral diseases.

The silica composition includes a friction silica and a thickening silica, the friction silica having a dentin friction value of less than 130.

In the daily tooth brushing process, the higher the friction value of the ointment is, the better the cleaning effect is, meanwhile, the higher the hardness of enamel on the outer layer of the tooth is, the limited influence of the abrasive is, however, although the dentin is wrapped in the tooth, only a thin layer of cementum wraps the dentin at the junction of the tooth and the gum, and once the fragile cementum is abraded, the less hard dentin can be completely exposed. The prevalence rate of periodontitis in China is very high and reaches 80% -90%. On the other hand, periodontitis causes gingival atrophy, once gingival atrophy occurs, cementum is exposed, and from the clinical experience, many people cannot well master a proper tooth brushing method, and from both points of view, if a product with a high friction value is used, teeth are damaged, so that damage to teeth can be effectively alleviated by using a friction-type silica having a dentin friction value of less than 130 as an abrasive.

The proportion of the friction type silicon dioxide to the thickening type silicon dioxide is 1: 2-3.

The raw material of the marrubium vulgare extract is one of the leaves, branches, petals and fruits of the marrubium vulgare;

or a mixture of leaf blades and branches of the European summer solstice according to a ratio of 5: 2;

or the mixture of the leaf of the European summer solstice, the branch of the European summer solstice, the petal of the European summer solstice and the fruit of the European summer solstice according to the proportion of 15:3:2: 2.

The marrubium vulgare is also called yue fu grass, belongs to the marrubium vulgare, has the smell like thyme, has square stems, is mainly distributed in Yili areas of Xinjiang in China, and can be used for treating chronic diseases of respiratory organs in the aspect of medicine and can be used as a substitute of Jinji naoshan cream skin; meanwhile, the marrubium vulgare extract can calm and soothe, detoxify and expel toxin, reduce the phenomenon of blood vessel congestion, effectively resist histamine and eliminate allergen.

The marrubium vulgare extract is used in a toothpaste formula, can help to remove toxic oxides which damage protein and lipid structures, promote cell metabolism, improve the bad state of gum, relieve the sensitive phenomenon and effectively improve the oral health index. The natural bactericidal component contained in the marrubium vulgare extract can help to inhibit the harm in the oral cavity and promote the balance of oral flora, and the oral cavity has faint scent and fresh breath like bathing forest.

The preparation method of the marrubium vulgare extract comprises the following steps:

b, crushing the dried raw material to obtain powder;

and C, leaching the powder by using ethanol with the weight part being 8-10 times that of the powder, wherein the leaching times are 2-5.

The water content of the dried raw material in the step A is less than 5%.

And the particle diameter of the powder in the step B is less than 200 meshes.

And the concentration of the ethanol in the step C is 65-75%.

Example 1:

a desensitizing toothpaste containing an extract of marrubium vulgare is composed of the following components in percentage by mass: silica composition: 18.5%, sorbitol: 59%, polyethylene glycol 600: 5%, glycerin: 5%, hydroxypropyl guar gum: 0.4%, hydroxyethyl cellulose: 0.4%, sodium saccharin: 0.25%, sodium lauryl sulfate: 2.4% and essence: 1.1%, cooling agent: 0.05%, methyl paraben: 0.1%, pigment: 0.002%, marrubium vulgare extract: 0.1%, cymene: 0.1%, thymol: 0.03%, strontium chloride: 0.5%, allantoin: 0.2%, tranexamic acid: 0.05%, potassium chloride: 0.5%, sodium azulene sulfonate: 0.5 percent and the balance of deionized water.

Wherein the ratio of the friction type silica to the thickening type silica in the silica composition is 1:2, and the dentin friction value of the friction type silica is 120-130.

Example 2:

silica composition: 16.5%, sorbitol: 52%, polyethylene glycol 600: 4% and glycerin: 6% and hydroxypropyl guar gum: 0.3%, hydroxyethyl cellulose: 0.3%, sodium saccharin: 0.4%, sodium lauryl sulfate: 2.2% and essence: 0.8%, cooling agent: 0.08%, methyl paraben: 0.15%, pigment: 0.004%, marrubium vulgare extract: 0.15%, cymene: 0.2%, thymol: 0.07%, strontium chloride: 0.4%, allantoin: 0.25%, tranexamic acid: 0.1%, potassium chloride: 0.5%, sodium azulene sulfonate: 0.5 percent and the balance of deionized water.

Comparative example 1:

the present comparative example is different from example 1 in that the silica of friction type has a dentin friction value of 190-210.

Comparative example 2:

this comparative example differs from example 1 in that no friction silica was added.

Comparative example 3:

this comparative example differs from example 1 in that no marrubium vulgare extract was added to the formulation.

Comparative example 4:

the comparative example differs from example 1 in that the content of marrubium vulgare extract in the formulation is 0.03%.

And (4) performance testing:

test 1:

1. test materials: example 1, example 2, comparative examples 1-4.

2. Test subjects: 120 subjects are selected to participate in the test, and the male and the female account for half of the test; photographing oral gums of a subject; the average was divided into example 1, example 2, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, each of which was 20 persons.

3. The test method comprises the following steps: the subjects brushed their teeth in the morning and evening 1 time each for 3 minutes with the corresponding toothpaste for 1 week continuously. All the subjects in each group can not use other oral cavity cleaning products in the test period, the oral cavity gingiva of the subjects are photographed after 1 week, the effects before and after use are compared, and the statistics is carried out on the experimental subjects with obviously improved oral cavity gingiva inflammation before and after the test. The statistical results are shown in table 1:

TABLE 1

As is apparent from the data in table 1, the toothpastes of examples 1, 2 and 2 have a significant improvement effect on oral gingival inflammation, and the toothpaste of comparative example 2, in which no abrasive silica is added, has the best improvement effect because it has the least damage to the gingival, and meanwhile, according to the data of comparative example 1, the abrasive agent with a high dentin abrasion value has a greater damage to the gingiva and dentin, and can inhibit the improvement of gingival inflammation to a certain extent; comparative observation of the data of example 1, comparative example 3 and comparative example 4 shows that the marrubium vulgare extract has significant efficacy in improving oral gingival inflammation.

Test 2:

1. test materials: toothpaste prepared according to example 1, example 2 and comparative examples 1-4.

2. Test subjects: 120 subjects are selected to participate in the test, and the male and the female account for half of the test; the average was divided into example 1, example 2, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, each of which was 20 persons.

3. The test method comprises the following steps: the subjects use the corresponding toothpastes to brush teeth respectively for 1 time in the morning and evening, each time lasts for 3 minutes and lasts for 1 week, and then the used toothpastes are graded and evaluated, wherein the grading contents comprise the cleaning effect, the anti-allergy effect and the breath refreshing effect of the toothpastes, the grading score is 1-5, and the grading score of 5 is the best effect. The average score is shown in table 2:

TABLE 2

As can be seen from the data in table 2, the toothpaste added with the marrubium vulgare extract has good anti-allergy effect and refreshing effect, and meanwhile, although the cleaning effect of the comparative example 1 is remarkable, the oral inflammation cannot be relieved and the anti-allergy toothpaste cannot effectively play a role due to the fact that the toothpaste has a high friction value and is greatly damaged to gum tissues and dentin.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims

1. A desensitizing toothpaste comprising an extract of marrubium vulgare, characterized by: the paint comprises the following components in percentage by mass: silica composition: 15-25%, sorbitol: 40-70%, polyethylene glycol 600: 3-8%, glycerol: 3-8%, hydroxypropyl guar gum: 0.1-2%, hydroxyethyl cellulose: 0.1-2%, saccharin sodium: 0.1-2%, sodium lauryl sulfate: 1-10%, essence: 0.5-2%, cooling agent: 0.01-1%, methyl paraben: 0.01-0.15%, pigment: 0.001-0.01%, marrubium vulgare extract: 0.1-0.5%, cymene: 0.01-0.5%, thymol: 0.01-0.5%, strontium chloride: 0.1-2%, allantoin: 0.1-2%, tranexamic acid: 0.01-0.2%, potassium chloride: 0.1-2%, sodium azulene sulfonate: 0.01-1% and the balance of deionized water;

the silica composition comprises a friction silica and a thickening silica, the friction silica having a dentin friction value of less than 130;

the proportion of the friction type silicon dioxide to the thickening type silicon dioxide is 1: 2-3;

2. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 1, wherein: silica composition: 18.5%, sorbitol: 59%, polyethylene glycol 600: 5%, glycerin: 5%, hydroxypropyl guar gum: 0.4%, hydroxyethyl cellulose: 0.4%, sodium saccharin: 0.25%, sodium lauryl sulfate: 2.4% and essence: 1.1%, cooling agent: 0.05%, methyl paraben: 0.1%, pigment: 0.002%, marrubium vulgare extract: 0.1%, cymene: 0.1%, thymol: 0.03%, strontium chloride: 0.5%, allantoin: 0.2%, tranexamic acid: 0.05%, potassium chloride: 0.5%, sodium azulene sulfonate: 0.01-0.5 percent, and the balance of deionized water.

3. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 1, wherein: the preparation method of the marrubium vulgare extract comprises the following steps:

b, crushing the dried raw material to obtain powder;

4. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 3, wherein: the water content of the dried raw material in the step A is less than 5%.

5. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 3, wherein: and the particle diameter of the powder in the step B is less than 200 meshes.

6. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 3, wherein: and the concentration of the ethanol in the step C is 65-75%.

7. The allergy-relieving toothpaste containing an extract of marrubium vulgare according to claim 4, wherein: the leaching time in the step C is 65-75min, and the leaching temperature is 65-75 ℃.