CN101062005B - Medical toothpaste including sodium azulene sulfonate - Google Patents
Medical toothpaste including sodium azulene sulfonate Download PDFInfo
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- CN101062005B CN101062005B CN2007100574171A CN200710057417A CN101062005B CN 101062005 B CN101062005 B CN 101062005B CN 2007100574171 A CN2007100574171 A CN 2007100574171A CN 200710057417 A CN200710057417 A CN 200710057417A CN 101062005 B CN101062005 B CN 101062005B
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Abstract
The invention discloses a pharmaceutical toothpaste, wherein each 100g of the toothpaste base material contains sodium azulenesulfonate 0. 01-1g and 0. 1-20% of Chinese herbal constituents including honeysuckle flower, capsule of weeping forsythia, isatic root, dandelion, Philippine violet herb, wild chrysanthemum flower, purslane, cortex dictamni radicis,Chinese olive, bamboo leaves, green tea, mentha and mulberry leaf.
Description
Technical field
The present invention relates to a kind of toothpaste, particularly relate to a kind of medicated toothpaste that contains Sodium Azulenesulfonate that can obviously alleviate or remove oral pathology symptoms such as gingivitis, periodontitis, alveolar abscess, oral ulcer.
Background technology
Intraoral periodontal support tissue is subjected to local excitation, as tartar, food impaction, bad dummy etc., secular mechanical stimulus, denture are uneven, part tooth gmatjpdumamics burden is excessive, and incorrect method for brushing teeth, chemicals, burn, hypovitaminosis C, oral cavity bacterium growth etc. all can cause oral cavity commonly encountered diseases such as gingivitis, periodontitis and alveolar abscess.
At present, occur the medicated toothpaste of a lot of treatments oral cavity commonly encountered diseases at home on the market, it mainly contains Chinese medicinal toothpaste.Chinese medicinal toothpaste is to have added the Chinese medicine with heat clearing away, Detoxication on the basis of ordinary toothpaste, and gingivitis, periodontitis, halitosis are had definite therapeutical effect, and the inflammation of alleviating gingiva is had certain assosting effect.And antiinflammatory toothpaste is to have added some antibacterials on the basis of ordinary toothpaste, is used to suppress the formation of dental plaque.But the antiinflammatory toothpaste that adds antibacterials can not life-time service, otherwise can cause the normal flora imbalance oral cavity in, generally is applied to replacing in 1～2 month once.
Sodium Azulenesulfonate is the very little antiinflammatory of a kind of side effect, antiulcerative, particularly be equipped with Chinese herbal medicine common oral disease is had the good curing effect, can effectively eliminate symptoms such as the edema that causes by above-mentioned disease, hyperemia, abscess, gingival hemorrhage, halitosis, odontoseisis.Oral ulcer is a kind of diseases of oral mucosa of outbreak repeatedly, and Sodium Azulenesulfonate is equipped with Chinese herbal medicine oral ulcer is also had good curative effect.
Pharmacological research to Sodium Azulenesulfonate shows that Sodium Azulenesulfonate has non-steroidal antiinflammation and anti-stick film ulcer effect, and main pharmacology is: antiinflammatory, promotion mucosa metabolism, and epidermis forms, but antibacterial action is very weak.In ordinary toothpaste, add Sodium Azulenesulfonate and in the oral cavity, use and can not destroy normal oral cavity flora balance, and inflammatory reaction such as intraoral red, swollen, hot, pain are had good therapeutical effect.
Summary of the invention
Technical problem to be solved by this invention is that a kind of medicated toothpaste that contains Sodium Azulenesulfonate that can obviously alleviate or remove oral pathology symptoms such as gingivitis, periodontitis, alveolar abscess, oral ulcer is provided.
The technical solution adopted in the present invention is: a kind of medicated toothpaste that contains Sodium Azulenesulfonate, the Sodium Azulenesulfonate that in per 100 gram toothpaste matrixes, adds 0.01～1 gram, also adding has 0.1～20% Chinese medicine ingredients, and its Chinese medicine ingredients is a kind of in Flos Lonicerae and the Herba Lophatheri.
Technical scheme in addition of the present invention is: a kind of medicated toothpaste that contains Sodium Azulenesulfonate, in per 100 gram toothpaste matrixes, add 0.01～1 Sodium Azulenesulfonate that restrains, and also adding has 0.1～20% Chinese medicine ingredients, and its Chinese medicine ingredients is Flos Lonicerae and Herba Lophatheri.
The medicated toothpaste that contains Sodium Azulenesulfonate of the present invention, owing in common toothpaste, added Sodium Azulenesulfonate and had the Chinese medicine of heat clearing away, Detoxication, to common oral inflammation, gingival hemorrhage, swell and ache, diseases such as oral ulcer, halitosis have good preventing and therapeutic effect.And the medicated toothpaste that contains Sodium Azulenesulfonate of the present invention can not destroy normal oral cavity flora balance, can life-time service.
The specific embodiment
Below in conjunction with specific embodiment, describe the medicated toothpaste that contains Sodium Azulenesulfonate of the present invention in detail.
The medicated toothpaste that contains Sodium Azulenesulfonate of the present invention is the Sodium Azulenesulfonate that adds 0.01～1 gram in per 100 gram toothpaste matrixes.
Can add again also in above-mentioned per 100 gram toothpaste matrixes that 0.1～20% Chinese medicine ingredients, its Chinese medicine ingredients are arranged is one or more in Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Taraxaci, Herba Violae, Flos Chrysanthemi, Herba Portulacae, Cortex Dictamni, Fructus Canarii, Herba Lophatheri, green tea, Herba Menthae, the Folium Mori.
Above-mentioned toothpaste matrix includes: calcium bicarbonate, carboxymethyl cellulose, glucide, glycerol, sodium lauryl sulphate, tetrasodium pyrophosphate, calcium phosphate dibasic anhydrous, dicalcium phosphate dehydrate, sorbitol, sodium laurylsulfate, calcium carbonate, soap flakes, starch, distilled water, essence, spice etc.
The Sodium Azulenesulfonate chemical name that uses in the medicated toothpaste of the present invention is 1.4-dimethyl-7-isopropyl-3-Sodium Azulenesulfonate, and chemical general formula is: C
15H
17SO
3Na1/2H
2O, structural formula is:
It in the embodiments of the invention Sodium Azulenesulfonate that in every 100g ordinary toothpaste substrate, adds 0.01～1g; The Flos Lonicerae leaching liquid of 3～5g; The Herba Lophatheri leaching liquid of 2～4g.Specific embodiment is as follows.
Embodiment 1:(unit gram)
Calcium bicarbonate 49
Carboxymethyl cellulose 1.2
Glucide 0.3
Glycerol 25
Sodium lauryl sulphate 3
Tetrasodium pyrophosphate 1
Distilled water 19.2
Essence 1.3
Sodium Azulenesulfonate 0.02
Flos Lonicerae leaching liquid 3
Herba Lophatheri leaching liquid 2
Embodiment 2:(unit gram)
Calcium phosphate dibasic anhydrous 2
Dicalcium phosphate dehydrate 45
Carboxyl methyl cellulose 1
Glucide 0.4
Glycerol 10
Sorbitol 10
Sodium laurylsulfate 2
Distilled water 28.6
Essence 1
Sodium Azulenesulfonate 0.025
Flos Lonicerae leaching liquid 4
Herba Lophatheri leaching liquid 3
Embodiment 3:(unit gram)
Calcium carbonate 40
Glucide 0.2
Glycerol 15
Soap flakes 10
Starch 5
Spice 1
Distilled water 28.8
Sodium Azulenesulfonate 0.03
Flos Lonicerae leaching liquid 5
Herba Lophatheri leaching liquid 4
Observation of curative effect:
In order to observe the medicated toothpaste curative effect that is added with Sodium Azulenesulfonate and Chinese medicinal ingredients, use the Cavia porcellus that manually causes suffering from gingivitis to test.Select for use under the healthy guinea pig room temperature and raise a week, body weight reaches 250g and treats the experiment use.Test divides 4 groups, and 25 every group, with 4 positions of pricking wound Cavia porcellus gums, manufacture of intraocular gingivitis.After being inflamed 24 hours, inflammation is observed by the swelling degree.The swelling degree at each position was estimated with 5 stages, and its inflammation swelling degree is closed with score and is: normal 0 minute; Some swollen 1 minute a little; Obviously swollen 2 minutes; Quite swollen 3 minutes; Very swollen 4 minutes.With the swelling degree of artificial acupuncture Cavia porcellus gingiva after 24 hours is radix, calculates the medicated toothpaste scribble Sodium Azulenesulfonate and Chinese medicinal ingredients and the ordinary toothpaste recovery rate the 2nd to the 8th swelling degree, and its computing formula is as follows:
Recovery rate=(inflammation degree score value/acupuncture that 1-observes is inflammation degree score value after 24 hours) * 100
Observed result please see Table one.The data of comparison sheet one are as can be seen: three groups of data using the medicated toothpaste that is added with Sodium Azulenesulfonate and Chinese medicinal ingredients than the artificial Cavia porcellus gingivitis inflammation swelling degree of ordinary toothpaste recover fast, and effect is obvious.
Table 1:
Claims (2)
1. a medicated toothpaste that contains Sodium Azulenesulfonate is characterized in that, adds the Sodium Azulenesulfonate of 0.01～1 gram in the toothpaste matrixes at per 100 grams, adds also that 0.1～20% Chinese medicine ingredients, its Chinese medicine ingredients are arranged is a kind of in Flos Lonicerae and the Herba Lophatheri.
2. a medicated toothpaste that contains Sodium Azulenesulfonate is characterized in that, adds the Sodium Azulenesulfonate of 0.01～1 gram in per 100 gram toothpaste matrixes, and also adding has 0.1～20% Chinese medicine ingredients, and its Chinese medicine ingredients is Flos Lonicerae and Herba Lophatheri.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100574171A CN101062005B (en) | 2007-05-22 | 2007-05-22 | Medical toothpaste including sodium azulene sulfonate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100574171A CN101062005B (en) | 2007-05-22 | 2007-05-22 | Medical toothpaste including sodium azulene sulfonate |
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| Publication Number | Publication Date |
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| CN101062005A CN101062005A (en) | 2007-10-31 |
| CN101062005B true CN101062005B (en) | 2011-06-08 |
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| CN2007100574171A Active CN101062005B (en) | 2007-05-22 | 2007-05-22 | Medical toothpaste including sodium azulene sulfonate |
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Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102000005B (en) * | 2010-11-27 | 2013-03-27 | 天津市顶硕科贸有限公司 | Oral care solution |
| CN102160886A (en) * | 2011-03-30 | 2011-08-24 | 天津市顶硕科贸有限公司 | Compound buccal tablet containing sodium azulene sulfonate and application |
| CN102267929B (en) * | 2011-06-20 | 2014-02-19 | 四川国康药业有限公司 | Preparation of novel N-amino acid substituted azulene sulfamide medicine and anti-gastric ulcer actions thereof |
| CN102228417A (en) * | 2011-06-27 | 2011-11-02 | 天津市顶硕科贸有限公司 | Chinese herbal medicine toothpaste composition containing sodium gualenate |
| CN102283949B (en) * | 2011-08-31 | 2014-03-19 | 天津市顶硕科贸有限公司 | Spraying agent containing sodium gualenate for treating canker sore |
| CN102600122A (en) * | 2011-12-02 | 2012-07-25 | 辽宁盛生医药集团有限公司 | Paster for treating dental ulcer and preparation method thereof |
| CN102579312B (en) * | 2012-03-23 | 2013-12-11 | 常熟市虞山绿茶有限公司 | Toothpaste for preventing and treating gingivitis and preparation method for toothpaste |
| CN102805717B (en) * | 2012-08-28 | 2013-11-06 | 吴嵩滨 | Preparation method of beautyberry herbal toothpaste |
| CN102793641B (en) * | 2012-08-28 | 2013-09-25 | 吴嵩滨 | Preparation method of beautyberry herbal mouth wash |
| CN103919709B (en) * | 2014-03-24 | 2016-09-07 | 顾玉奎 | A kind of Chinese material bathe agent and preparation method thereof |
| CN104644460A (en) * | 2015-03-06 | 2015-05-27 | 北京华素制药股份有限公司 | Medicinal toothpaste composition and preparation method and application thereof |
| CN104958220A (en) * | 2015-07-13 | 2015-10-07 | 李丽芬 | Traditional Chinese medicine toothpaste |
| CN106265423B (en) * | 2016-08-23 | 2020-04-10 | 广州立白企业集团有限公司 | Oral care composition with effects of clearing fire and relieving pain |
| CN107412064A (en) * | 2017-08-15 | 2017-12-01 | 何家平 | A kind of Chinese herbal toothpaste |
| CN107308067A (en) * | 2017-08-15 | 2017-11-03 | 何家平 | A kind of compound Chinese herbal medicine toothpaste |
| CN107811890A (en) * | 2017-10-31 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | A kind of oral cavity caring toothpaste composition |
| CN107929428B (en) * | 2017-12-20 | 2021-01-26 | 弘美制药（中国）有限公司 | Composition for oral cavity and application thereof |
| CN108042384B (en) * | 2018-01-08 | 2020-07-10 | 弘美制药（中国）有限公司 | A composition with oral cleaning and treating effects |
| CN108175730B (en) * | 2018-03-05 | 2020-06-16 | 弘美制药（中国）有限公司 | Composition for oral cavity and application and preparation method thereof |
| CN108606939B (en) * | 2018-03-14 | 2020-07-07 | 弘美制药（中国）有限公司 | Composition with oral health care function and application and preparation method thereof |
| CN112089680A (en) * | 2019-05-31 | 2020-12-18 | 王飞 | Effervescent tablet for self-made mouthwash |
| CN113288833B (en) * | 2021-04-02 | 2022-08-30 | 北京圣永制药有限公司 | A toothpaste containing extract of marrubium vulgare for relieving sensitivity |
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| CN1947697A (en) * | 2006-09-27 | 2007-04-18 | 天津市希勒玛生物科技有限公司 | Herbal water and its prepn. method |
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| CN101062005A (en) | 2007-10-31 |
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Address after: 300457, Tianjin free trade test area (Airport Economic Zone), No. 80 North River Road Airport Business Park East 8 building, B205 Patentee after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300384 Tianjin Huayuan Industrial Zone, Road No. 3 1001-1 Patentee before: Tianjin top pharmaceutical technology Co., Ltd. |
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