CN106265423B - Oral care composition with effects of clearing fire and relieving pain - Google Patents
Oral care composition with effects of clearing fire and relieving pain Download PDFInfo
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- CN106265423B CN106265423B CN201610707791.0A CN201610707791A CN106265423B CN 106265423 B CN106265423 B CN 106265423B CN 201610707791 A CN201610707791 A CN 201610707791A CN 106265423 B CN106265423 B CN 106265423B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses an oral care composition with the effects of clearing away fire and relieving pain, which is prepared from the following raw materials in percentage by mass: 0.01 to 1 percent of bezoar, 0.1 to 5 percent of scutellaria root extract, 0.1 to 5 percent of honeysuckle extract, 0.1 to 5 percent of cimicifuga rhizome extract, 0.01 to 0.5 percent of borneol, 0.1 to 5 percent of sodium azulene sulfonate, 0.1 to 5 percent of nicotinamide and the balance of base materials. Aiming at the population easy to cause oral cavity inflammation and toothache and the population with symptoms of gingivitis and periodontitis, the oral care composition has the functions of cleaning the oral cavity and freshening breath, and has the effects of clearing away heat and relieving pain, relieving toothache, gingival bleeding and the like through a compounding technology.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to an oral care composition with effects of clearing heat and relieving pain.
Background
Toothache is a common oral disease, and symptoms of the toothache include root pain, red and swollen gum, pain due to irritation, swelling of cheek and the like. The toothache is caused mainly by the tooth itself having symptoms of pain under the influence of internal and external factors, such as caries, periodontitis, pulpitis, gingivitis, etc. Once people have toothache symptoms, great pain and inconvenience are brought to daily life. The method for preventing and treating toothache is a simple and practical method for keeping on brushing teeth with the traditional Chinese medicine toothpaste with the analgesic effect every day except that people pay attention to oral cavity cleanness and sanitation and eat more light foods everyday.
In modern society, people have fast pace of life and high working pressure, and the problems of toothache, oral ulcer and the like generally exist, so that the normal life of people is greatly influenced, and therefore, the toothpaste which can clear heat, reduce internal heat, reduce swelling and relieve pain in the daily use process is urgently needed to be used as a daily oral care product.
At present, a lot of products aiming at the problem of toothache exist in the market, and the added active ingredients are different, for example, the butylboron toothpaste added with clove and borax has excellent analgesic and astringent effects, but the borax has certain toxicity; such as toothpaste with fluoride added for dental pain caused by dental caries; the anti-sensitivity toothpaste aims at sensitive pain caused by enamel damage; however, the traditional Chinese medicine components are adopted to clear fire and relieve pain, and the toothpaste is not abundant.
Disclosure of Invention
In view of the above, there is a need to provide an oral care composition having the effects of clearing heat and relieving pain. The composition is added with calculus bovis, Borneolum Syntheticum, Scutellariae radix extract, flos Lonicerae extract, and cimicifugae rhizoma extract, and has effects of clearing away fire, relieving pain, and relieving toothache, gingival swelling and pain, and stomatocace pain.
The specific technical scheme is as follows:
the oral care composition with the effects of clearing heat and relieving pain is prepared from the following raw materials in percentage by mass:
0.01 to 1 percent of bezoar, 0.1 to 5 percent of scutellaria root extract, 0.1 to 5 percent of honeysuckle extract, 0.1 to 5 percent of cimicifuga rhizome extract, 0.01 to 0.5 percent of borneol, 0.1 to 5 percent of sodium azulene sulfonate, 0.1 to 5 percent of nicotinamide and the balance of base materials.
The above base is selected by those skilled in the art according to the type of oral care composition to be prepared, and when preparing toothpaste, the base includes an abrasive, a humectant, a binder, a surfactant, an essence, a sweetener, an efficacy additive, a pigment, a preservative, and water;
when preparing mouthwash, the base material comprises humectant, emulsifier, essence, sweetener, antibacterial agent, pH regulator, efficacy additive, pigment, antiseptic and water;
when preparing an oral spray, the base material includes a humectant, an emulsifier, a flavoring agent, ethanol, an essence, an efficacy additive, a pigment, a preservative, and water.
In some embodiments, the total amount of the bezoar, the scutellaria baicalensis extract, the honeysuckle extract, the cimicifuga foetida extract, the borneol, the sodium azulene sulfonate and the nicotinamide added accounts for 1-10% of the oral care composition with the effects of clearing heat and relieving pain.
In some embodiments, the oral care composition with the effects of clearing heat and relieving pain is prepared from the following raw materials in percentage by mass:
bezoar 0.03-0.1%, scutellaria root extract 0.5-2.0%, honeysuckle extract 0.5-2.5%, cimicifuga rhizome extract 0.5-2%, borneol 0.03-0.1%, sodium azulene sulfonate 0.5-2.0%, nicotinamide 0.5-2.0% and the rest is base material;
the total adding amount of the bezoar, the scutellaria baicalensis extract, the honeysuckle extract, the cimicifuga foetida extract, the borneol, the sodium azulene sulfonate and the nicotinamide accounts for 3-7% of the oral care composition with the effects of clearing away fire and relieving pain.
In some of these embodiments, the oral care composition is a toothpaste, a mouthwash, an oral spray.
In some embodiments, the oral care composition is toothpaste, and the base material comprises the following raw materials in percentage by mass, and the following raw materials account for the oral care composition with the effects of clearing heat and relieving pain:
10-45% of grinding agent, 10-60% of humectant, 0.2-3% of adhesive, 0.5-4% of surfactant, 0.5-3% of essence, 0.1-1% of sweetening agent, 0-3% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the sum of the mass percentages of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
In some of these embodiments, the abrasive is selected from at least one of hydrated silica, calcium carbonate, dibasic calcium phosphate, microcrystalline cellulose;
the humectant is at least one selected from sorbitol, glycerol, polyethylene glycol, propylene glycol and xylitol;
the adhesive is selected from at least one of sodium carboxymethylcellulose, carrageenan, xanthan gum and guar gum;
the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine; or
The surfactant is: at least one selected from sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine, at least one selected from tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether;
the sweetener is at least one selected from saccharin sodium, sucralose, stevioside and aspartame;
the functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or bisabolol, paeonol, eugenol, and dipotassium glycyrrhizinate.
The base material for preparing the toothpaste comprises the following raw materials in part by weight: 15-30% of hydrated silica, 10-60% of humectant, 0.2-1% of sodium carboxymethylcellulose, 0.2-1% of xanthan gum, 0.5-3% of surfactant, 0.5-2.0% of essence, 0.1-0.6% of sweetening agent and 0-3% of efficacy additive.
In some embodiments, the oral care composition is a mouth wash, and the base material comprises the following raw materials in percentage by mass, and the following raw materials account for the oral care composition with the effects of clearing heat and relieving pain:
5.0-30.0% of humectant, 1.0-10.0% of emulsifier, 0.1-1.0% of essence, 0.05-1.0% of sweetening agent, 0.01-1.0% of antibacterial agent, 0-3.0% of pH regulator, 0-3.0% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the sum of the mass percentages of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
In some of these embodiments, the humectant is selected from at least one of sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol;
the emulsifier is at least one selected from Tween, polyoxyethylene and polyoxypropylene block copolymer, and hydrogenated castor oil polyoxyethylene ether, or
The emulsifier is as follows: at least one selected from tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether, and at least one selected from sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine;
the sweetener is at least one selected from saccharin sodium, sucralose, stevioside and aspartame;
the antibacterial agent is selected from cetylpyridinium chloride or chlorhexidine;
the pH regulator is at least one selected from disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium pyrophosphate and sodium malate;
the functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or bisabolol, paeonol, eugenol, and dipotassium glycyrrhizinate.
In some embodiments, the oral care composition is an oral spray, and the base material comprises the following raw materials in percentage by mass, and the following raw materials are in percentage by mass of the oral care composition with the effects of clearing heat and relieving pain:
5-40.0% of humectant, 1-10.0% of emulsifier, 0.1-3.0% of flavoring agent, 0-20.0% of ethanol, 0.1-2.0% of essence, 0-3.0% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the total mass percentage of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
In some of these embodiments, the humectant is selected from at least one of sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol;
the emulsifier is at least one selected from Tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether;
the flavoring agent is at least one selected from menthol, borneol, menthyl lactate, saccharin sodium, sucralose and stevioside;
the functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or bisabolol, paeonol, eugenol, and dipotassium glycyrrhizinate.
The bezoar, the scutellaria baicalensis extract and the honeysuckle extract are used together with the borneol and the cimicifuga foetida extract, wherein the bezoar, the scutellaria baicalensis extract and the honeysuckle extract are mainly used for clearing heat and reducing internal heat and removing internal deficiency fire; the cimicifugae rhizoma extract has effects of invigorating yang, relieving exterior syndrome, and relieving headache, chills and fever, laryngalgia, and aphtha; the borneol has the effects of sterilizing, clearing heat from throat and benefiting throat; the sodium azulene sulfonate has the function of repairing the oral mucosa; the nicotinamide has strong oxidation resistance, and has the effects of relieving swelling and pain and repairing mucosa together with borneol and sodium azulene sulfonate. The traditional Chinese medicine composition is combined with the raw materials, and can eliminate heat and toxic materials, relieve swelling and pain, and repair oral environment, so that symptoms such as toothache, gum swelling and pain, gingivitis, oral ulcer and the like can be relieved.
The invention has the advantages and beneficial effects that:
1. according to the invention, the bezoar, the scutellaria baicalensis extract and the honeysuckle extract are compounded with the borneol and the cimicifuga foetida extract for the first time to serve as functional components for clearing fire and relieving pain, the traditional Chinese medicine components supplement each other to achieve the purpose of clearing fire and relieving pain together, and meanwhile, the sodium azulene sulfonate and the nicotinamide are added to sterilize and diminish inflammation, repair oral mucosa, improve the metabolism of oral cells and relieve pain caused by red and swollen gums, oral ulcers and the like;
2. analgesic experiments and clinical experiments prove that the effects of relieving toothache and repairing dental ulcer are obviously enhanced.
3. The oral care composition has the effects of relieving oral excessive internal heat, toothache and oral ulcer, is quick in effect taking, has no toxic or side effect, and is suitable for being used when symptoms of oral excessive internal heat and toothache appear and also suitable for being used for prevention in daily life.
Detailed Description
The raw materials used in the invention are all common products sold in the market.
The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to the examples. In the following examples, the percentages referred to are by weight unless otherwise indicated.
Example 1
The toothpaste with the effects of clearing fire and relieving pain is prepared from the following raw materials in percentage by mass: bezoar 0.1%, scutellaria baicalensis extract 1.5%, honeysuckle extract 1.0%, cimicifuga foetida extract 2.0%, borneol 0.03%, sodium azulene sulfonate 1.0%, nicotinamide 1.0%, hydrated silica 25.0%, sorbitol 40.0%, glycerin 5.0%, sodium carboxymethylcellulose 0.5%, xanthan gum 0.3%, sodium lauryl sulfate 1.6%, cocamidopropyl betaine 0.5%, essence 1.2%, sodium saccharin 0.2%, paeonol 0.1%, dipotassium glycyrrhizinate 0.1%, trace pigments (only meeting the national quality requirement standard), trace preservatives (only meeting the national quality requirement standard), and the balance of water.
The manufacturing process of the embodiment 1 comprises the following steps:
1) putting the weighed small materials such as bezoar, scutellaria baicalensis extract, honeysuckle extract, cimicifuga foetida extract, sodium azulene sulfonate, sodium saccharin, dipotassium glycyrrhizinate, pigment, preservative and the like and water into a liquid tank, stirring, sucking into an ointment making machine, and starting a stirrer to stir for 2-3 minutes;
2) sucking liquid materials such as sorbitol, glycerol and the like into a paste making machine, and starting a stirrer to stir uniformly;
3) putting sodium carboxymethylcellulose, xanthan gum, nicotinamide and half of hydrated silica into a powder bin, and stirring for 5-10 minutes to uniformly mix; then sucking the materials in the powder bin into a paste making machine, and stirring for 20-30 minutes;
4) adding the rest of hydrated silica and sodium lauryl sulfate into a paste making machine, and quickly stirring for 15 minutes in a vacuum state;
5) adding the metered essence (dissolved with borneol and paeonol) and the cocamidopropyl betaine into an ointment making machine, and starting vacuum stirring for 10-15 minutes; thus obtaining the paste.
Example 2
The toothpaste with the effects of clearing fire and relieving pain is prepared from the following raw materials in percentage by mass: 0.03% of bezoar, 0.5% of scutellaria baicalensis extract, 1.5% of honeysuckle extract, 1.0% of cimicifuga foetida extract, 0.05% of borneol, 1.3% of sodium azulene sulfonate, 0.5% of nicotinamide, 20.0% of hydrated silica, 55.0% of sorbitol, 3.0% of polyethylene glycol, 0.3% of sodium carboxymethylcellulose, 0.4% of carrageenan, 2.2% of sodium lauryl sulfate, 1.2% of essence, 0.15% of sucralose, 0.8% of sodium monofluorophosphate, trace pigments (only meeting the national quality requirement standard), trace preservatives (only meeting the national quality requirement standard), and the balance of water.
The manufacturing process of the embodiment 2 includes the following steps:
1) putting the weighed small materials such as bezoar, scutellaria baicalensis extract, honeysuckle extract, cimicifuga foetida extract, sodium azulene sulfonate, sucralose, sodium monofluorophosphate, pigment, preservative and the like and water into a liquid tank, stirring, sucking into a paste making machine, and starting a stirrer to stir for 2-3 minutes;
2) sucking liquid materials such as sorbitol, polyethylene glycol and the like into an ointment making machine, and starting a stirrer to stir uniformly;
3) putting sodium carboxymethylcellulose, carrageenan, nicotinamide and half of hydrated silica into a powder bin, and stirring for 5-10 minutes to uniformly mix; then sucking the materials in the powder bin into a paste making machine, and stirring for 20-30 minutes;
4) adding the rest of hydrated silica and sodium lauryl sulfate into a paste making machine, and quickly stirring for 15 minutes in a vacuum state;
5) adding the metered essence (with the borneol dissolved) into a paste making machine, and starting vacuum stirring for 10-15 minutes; thus obtaining the paste.
Example 3
The toothpaste with the effects of clearing fire and relieving pain is prepared from the following raw materials in percentage by mass: bezoar 0.08%, scutellaria baicalensis extract 1.0%, honeysuckle extract 0.5%, cimicifuga foetida extract 1.8%, borneol 0.1%, sodium azulene sulfonate 1.0%, nicotinamide 1.5%, calcium carbonate 32.0%, hydrated silica 5%, sorbitol 30.0%, propylene glycol 3.0%, sodium carboxymethylcellulose 0.5%, guar gum 0.4%, sodium lauryl sulfate 2.2%, essence 1.2%, saccharin sodium 0.1%, stevioside 0.5%, strontium chloride 2.0%, trace pigments (only required to meet the national quality requirement standard), trace preservatives (only required to meet the national quality requirement standard), and the balance of water.
The manufacturing process of the embodiment 3 includes the following steps:
1) putting the weighed small materials such as bezoar, scutellaria baicalensis extract, honeysuckle extract, cimicifuga foetida extract, sodium azulene sulfonate, saccharin sodium, stevioside, strontium chloride, pigment, preservative and the like and water into a liquid material tank, stirring, sucking into an ointment making machine, and starting a stirrer to stir for 2-3 minutes;
2) sucking liquid materials such as sorbitol, propylene glycol and the like into a paste making machine, and starting a stirrer to stir uniformly;
3) putting sodium carboxymethylcellulose, guar gum, nicotinamide and half of calcium carbonate into a powder bin, and stirring for 5-10 minutes to uniformly mix; then sucking the materials in the powder bin into a paste making machine, and stirring for 20-30 minutes;
4) adding the rest of calcium carbonate, hydrated silica and sodium lauryl sulfate into a paste making machine, and quickly stirring for 15 minutes in a vacuum state;
5) adding the metered essence (with the borneol dissolved) into a paste making machine, and starting vacuum stirring for 10-15 minutes; thus obtaining the paste.
Example 4
A mouth wash with effects of clearing fire and relieving pain is prepared from the following raw materials in percentage by mass:
bezoar 0.05%, scutellaria baicalensis extract 0.8%, honeysuckle extract 1.1%, cimicifuga foetida extract 0.8%, borneol 0.05%, sodium azulene sulfonate 1.0%, nicotinamide 0.5%, sorbitol 10.0%, glycerin 5.0%, propylene glycol 5.0%, poloxamer 3.0%, polysorbate-201.0%, cocamidopropyl betaine 0.5%, essence 0.2%, saccharin sodium 0.1%, cetylpyridinium chloride 0.5%, disodium hydrogen phosphate 0.6%, sodium dihydrogen phosphate 0.3%, sodium monochlorophosphate 0.8%, trace pigments (only meeting national quality requirement standards), trace preservatives (only meeting national quality requirement standards), and the balance of water.
The manufacturing process of the embodiment 4 comprises the following steps:
1) adding the weighed small materials such as bezoar, scutellaria baicalensis extract, honeysuckle extract, cimicifuga foetida extract, sodium azulene sulfonate, sodium saccharin, sodium monochloro phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, pigment, preservative and the like into water, and stirring for 2-5 minutes to dissolve the small materials to obtain a liquid phase;
2) adding appropriate amount of liquid materials such as sorbitol, glycerol, propylene glycol and the like into the liquid phase, and stirring for 2-5 minutes to dissolve the liquid materials;
3) adding poloxamer, polysorbate-20 and cetylpyridinium chloride, and stirring for 5-10 minutes; finally, sequentially adding the cocamidopropyl betaine, the nicotinamide and the essence (with the borneol dissolved), and stirring until a transparent uniform solution is formed;
4) standing, filtering, and filling into a storage tank for filling.
Example 5
An oral spray with the effects of clearing fire and relieving pain is prepared from the following raw materials in percentage by mass:
bezoar 0.05%, scutellaria baicalensis extract 0.5%, honeysuckle extract 2.5%, cimicifuga foetida extract 0.6%, borneol 0.06%, sodium azulene sulfonate 0.8%, nicotinamide 0.5%, sorbitol 15.0%, glycerol 6.0%, poloxamer 2.0%, polysorbate-201.0%, menthol 0.3%, ethanol 8.0%, essence 0.5%, saccharin sodium 0.15%, sodium monofluorophosphate 0.8%, trace pigment (only meeting the national quality requirement standard), trace preservative (only meeting the national quality requirement standard), and the balance of water.
The manufacturing process of the embodiment 5 comprises the following steps:
adding the weighed small materials such as bezoar, scutellaria baicalensis extract, honeysuckle extract, cimicifuga foetida extract, sodium azulene sulfonate, sodium saccharin, sodium monofluorophosphate, pigment, preservative and the like into water, and stirring for 2-5 minutes to dissolve the small materials to obtain a liquid phase; dissolving polysorbate-20 in glycerol, adding into liquid phase together with poloxamer, adding sorbitol, ethanol, and nicotinamide, and stirring; adding menthol and essence (with Borneolum dissolved), and stirring to obtain transparent uniform solution; filtering, and filling into a storage tank for filling.
Clinical test part-analgesia test
The test substance: the toothpastes (inventive toothpaste group 1, inventive toothpaste group 2), diclofenac diethylamine emulsion (nataline group), blank control (physiological saline) (blank control group), and toothpaste (toothpaste blank matrix group) with the raw materials containing only the base material part of example 1, which have the effects of clearing heat and relieving pain, which are prepared according to examples 1 and 2.
The experimental method comprises the following steps: healthy Kunming female mice are selected, the temperature of a hot plate instrument is controlled to be 55 +/-0.5 ℃, the mice are placed on a hot plate to measure the pain threshold value of each mouse (the time from the time that the mice contact the hot plate to lick the feet), and 30 qualified mice are selected and randomly divided into 5 groups when the time that the mice lick the feet is less than 5s or more than 30s and the skipper is abandoned. And (3) repeating the method for 2 times to measure the normal pain threshold of the mice in each group, wherein the interval between every two times is 15 minutes, and taking the average value of the normal pain threshold of the two times as the pain threshold of the mice in the group before administration.
The hind paw of each group of mice was administered with 0.2 g/mouse of the corresponding test substance, the blank group was administered with 0.2 ml/mouse of physiological saline, and the pain threshold of the mice was measured 3 minutes and 20 minutes after administration of the test substance. If the mouse still has no response for 60s, the mouse is taken out to avoid scalding, and the pain threshold is calculated as 60 s.
The toothpaste with the effects of clearing fire and relieving pain prepared according to the examples 1 and 2 is subjected to an analgesic experiment, and the toothpaste and a toothpaste blank matrix group are used as reference substances to be subjected to analgesic experiment verification. The results are shown in table 1:
From the data in the table above, it can be seen that: the toothpaste group of the invention has improved pain threshold values for mice at 3 minutes and 20 minutes, but has no obvious advantages compared with the nataline group at 20 minutes.
The analgesic test shows that: compared with a blank group, the pain threshold of the mice in the toothpaste group is obviously improved, and the toothpaste has an obvious analgesic effect. Clinical application proves that the invention achieves the aim.
Clinical laboratory-anti-inflammatory test
The test substance: toothpastes according to the invention prepared according to examples 1, 2 (inventive toothpaste group 1, inventive toothpaste group 2), toothpastes whose raw materials comprise only the binder fraction of example 1 (toothpaste blank base group), benzoic acid ointment (benzoic acid ointment group), blank control (physiological saline) (blank control group).
The experimental method comprises the following steps: anti-inflammatory effect of acute inflammation swelling of auricularia of mice caused by paraxylene
40 healthy Kunming white mice were selected and randomly divided into 5 groups of 8 mice each. In the experiment, 0.1ml of dimethylbenzene is smeared on the inner and outer surfaces of the right ear corridor of each animal in each group until inflammation occurs, and the left ear is not treated to be used as a self blank control group. After coating dimethylbenzene for 25min, each group of animals is respectively and uniformly coated with 0.1 g/animal sample on the inner and outer surfaces of the right ear corridor. After the test object is given for 1h, the white mouse is killed by dislocation of the cervical vertebra, the two ear galleries are cut off, a sample of the test object of the right ear gallery is washed off by normal saline, a dry cotton ball is used for wiping, two round lugs are chiseled at the same part by a puncher, and the weight of the right lug minus the weight of the left lug is taken as a swelling value.
From the data in the table above, it can be seen that: compared with a blank group, the toothpaste group disclosed by the invention can relieve the acute inflammation swelling auricular corridor value of a white mouse, and obviously inhibit acute inflammation swelling of the auricular corridor of the white mouse caused by xylene, so that the toothpaste disclosed by the invention has an obvious anti-inflammatory effect on acute inflammation.
Clinical trial for treating oral ulcer
Oral ulcer manifestation: one or more 2-15 mm round or oval oral mucosa can be seen, the edge is neat, shallow ulcer with a slightly concave surface is formed, the reddish halo around the ulcer is obvious sometimes, severe baking pain is often accompanied, and the ulcer is especially obvious when the ulcer is chewed and contacted with pungent food such as sour and spicy food.
The method comprises the following steps: the toothpaste of the invention is used for brushing teeth twice a day in the morning and evening, and each time is at least 3 minutes. Meanwhile, the mouthwash of the invention is used for gargling for more than 2 times, and gargling for at least 1 minute each time.
The curative effect standard is as follows: and (3) curing: the ulcer is completely cured, and the pain disappears; improvement: reduction of ulcer area or ulcer, pain relief; and (4) invalidation: the ulcer did not heal and pain was present.
The treatment results are as follows: in 12 cases, ulcer heals within 10 cases within 3-7 days, pain disappears, and the cure rate is 83%; in 2 cases, the ulcer was reduced and the pain was relieved.
According to the oral care composition prepared by the formula provided by the embodiment of the invention, a user can use the oral care composition once a day in the morning and at night or when oral discomfort symptoms occur, so that the symptoms of oral cavity excessive internal heat, toothache, gum swelling and pain, oral ulcer and the like can be relieved. The use of the oral care compositions of the present invention in the absence of any symptoms reduces the frequency of oral problems.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The oral care composition with the effects of clearing heat and relieving pain is characterized by being prepared from the following raw materials in percentage by mass:
bezoar 0.03-0.1%, scutellaria root extract 0.5-2.0%, honeysuckle extract 0.5-2.5%, cimicifuga rhizome extract 0.5-2%, borneol 0.03-0.1%, sodium azulene sulfonate 0.5-2.0%, nicotinamide 0.5-2.0% and the rest is base material;
the total adding amount of the bezoar, the scutellaria baicalensis extract, the honeysuckle extract, the cimicifuga foetida extract, the borneol, the sodium azulene sulfonate and the nicotinamide accounts for 3-7% of the oral care composition with the effects of clearing away fire and relieving pain.
2. The oral care composition with the effects of clearing heat and relieving pain according to claim 1, which is prepared from the following raw materials:
bezoar 0.1%, scutellaria root extract 1.5%, honeysuckle extract 1%, cimicifuga rhizome extract 2%, borneol 0.03%, sodium azulene sulfonate 1%, nicotinamide 1%, and the balance of base materials.
3. The oral care composition with the effects of clearing heat and relieving pain according to claim 1, wherein the bezoar is 0.03%, the scutellaria baicalensis extract is 0.5%, the honeysuckle extract is 1.5%, the cimicifuga foetida extract is 1%, the borneol is 0.05%, the sodium azulene sulfonate is 1.3%, the nicotinamide is 0.5%, and the balance is a base material.
4. The oral care composition with the effects of clearing heat and relieving pain according to any one of claims 1 to 3, wherein the oral care composition is toothpaste, mouthwash or oral spray.
5. The oral care composition with the effects of clearing heat and relieving pain according to claim 4, wherein the oral care composition is toothpaste, and the base material comprises the following raw materials in percentage by mass:
10-45% of grinding agent, 10-60% of humectant, 0.2-3% of adhesive, 0.5-4% of surfactant, 0.5-3% of essence, 0.1-1% of sweetening agent, 0-3% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the sum of the mass percentages of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
6. The oral care composition having the effects of clearing heat and relieving pain according to claim 5, wherein the abrasive is selected from at least one of hydrated silica, calcium carbonate, calcium hydrogen phosphate, microcrystalline cellulose;
the humectant is at least one selected from sorbitol, glycerol, polyethylene glycol, propylene glycol and xylitol;
the adhesive is selected from at least one of sodium carboxymethylcellulose, carrageenan, xanthan gum and guar gum;
the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine; or
The surfactant is: at least one selected from sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine, at least one selected from tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether;
the sweetener is at least one selected from saccharin sodium, sucralose, stevioside and aspartame;
the functional additive is at least one of sodium fluoride, sodium monofluorophosphate, potassium nitrate, strontium chloride, zinc citrate, zinc lactate, bisabolol, paeonol, eugenol and dipotassium glycyrrhizinate.
7. The oral care composition with the effects of clearing heat and relieving pain according to claim 4, wherein the oral care composition is a mouth wash, the base material comprises the following raw materials in percentage by mass, and the following raw materials are in percentage by mass of the oral care composition with the effects of clearing heat and relieving pain:
5.0-30.0% of humectant, 1.0-10.0% of emulsifier, 0.1-1.0% of essence, 0.05-1.0% of sweetening agent, 0.01-1.0% of antibacterial agent, 0-3.0% of pH regulator, 0-3.0% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the sum of the mass percentages of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
8. The oral care composition with the effects of clearing heat and relieving pain according to claim 7, wherein the humectant is selected from at least one of sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol;
the emulsifier is at least one selected from Tween, polyoxyethylene and polyoxypropylene block copolymer, and hydrogenated castor oil polyoxyethylene ether, or
The emulsifier is as follows: at least one selected from tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether, and at least one selected from sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate or cocamidopropyl betaine;
the sweetener is at least one selected from saccharin sodium, sucralose, stevioside and aspartame;
the antibacterial agent is selected from cetylpyridinium chloride;
the pH regulator is at least one selected from disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium pyrophosphate and sodium malate;
the functional additive is at least one of sodium fluoride, sodium monofluorophosphate, potassium nitrate, strontium chloride, zinc citrate, zinc lactate or bisabolol, paeonol, eugenol and dipotassium glycyrrhizinate.
9. The oral care composition with the effects of clearing heat and relieving pain according to claim 4, wherein the oral care composition is an oral spray, and the base material comprises the following raw materials in percentage by mass:
5-40.0% of humectant, 1-10.0% of emulsifier, 0.1-3.0% of flavoring agent, 0-20.0% of ethanol, 0.1-2.0% of essence, 0-3.0% of efficacy additive, trace pigment, trace preservative and the balance of water, wherein the total mass percentage of all the raw materials of the oral care composition with the effects of clearing fire and relieving pain is 100%.
10. The oral care composition with the effects of clearing heat and relieving pain according to claim 9, wherein the humectant is selected from at least one of sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol;
the emulsifier is at least one selected from Tween, polyoxyethylene and polyoxypropylene block copolymer and hydrogenated castor oil polyoxyethylene ether;
the flavoring agent is at least one selected from menthol, borneol, menthyl lactate, saccharin sodium, sucralose and stevioside;
the functional additive is at least one of sodium fluoride, sodium monofluorophosphate, potassium nitrate, strontium chloride, zinc citrate, zinc lactate, bisabolol, paeonol, eugenol and dipotassium glycyrrhizinate.
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CN104688810A (en) * | 2014-12-29 | 2015-06-10 | 昆明皕凯科技有限公司 | Antibacterial composition based on natural plant raw material and application of antibacterial composition |
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