CN108685833A - Containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof - Google Patents
Containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof Download PDFInfo
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- CN108685833A CN108685833A CN201810795274.2A CN201810795274A CN108685833A CN 108685833 A CN108685833 A CN 108685833A CN 201810795274 A CN201810795274 A CN 201810795274A CN 108685833 A CN108685833 A CN 108685833A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses it is a kind of containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is related to field of oral care, the toothpaste contains the natural nursing tooth-paste of propolis, Radix Notoginseng, moutan bark, the coptis, licorice, has significant curative effect to gingivitis, bleeding gums, canker sore, halitosis oral peculiar smell etc..Propolis, which has, promotes tissue repair, antibacterial bacteriostatic, anti-inflammatory, analgesia, hemostasia effect.Radix Notoginseng has promoting blood circulation and hemostasis, antithrombotic, enhancing immune, is effectively improved mucous membrane of mouth microcirculation.It is moutan bark clearing heat and cooling blood, anti-inflammatory analgesic, promoting blood circulation and removing blood stasis.Coptis clearing away the heart-fire, clearing heat and detoxicating, Anhydroalkannin is antiviral.Radix Glycyrrhizae has effects that heat-clearing, removing toxic substances, purging intense heat.Therefore used simultaneously in toothpaste so that the toothpaste analgesic antiphlogistic, resist gingivitis, bleeding gums and pain, repair oral cavity mucous membrane tissue containing propolis, Radix Notoginseng, moutan bark, the coptis, licorice, antibacterial anti-halitosis, oral peculiar smell effect is more notable.
Description
Technical field
The present invention relates to field of oral care, it is more particularly related to it is a kind of containing propolis, Radix Notoginseng, moutan bark,
The toothpaste and preparation method thereof of the coptis, Radix Glycyrrhizae.
Background technology
Canker sore is commonly called as " aphtha ", is a kind of common ulcerative damages illness for betiding mucous membrane of mouth, is more common in
The mucous membrane at the positions such as lip inside, tongue, tongue abdomen, cheek mucous membrane, soft palate, these positions lacks keratinization layer or angling is poor.Oral cavity
It is big that ulcer frequently occurs in people's stress, or is being busy with one's work, and rest is bad, or has indigestion or women premenstrual in the moon,
On the inside of lip, mouth bottom often occurs single or two or three of round or ovate aphthas on soft palate or tongue, and feels burning
Pain.Bleeding gums refer to gum spontaneity, or are bled on a small quantity caused by minimal irritation, and sucking, brush are embodied in
The trace of blood is carried in saliva when tooth, chewing harder food, for severe patient when gum is by minimal irritation, bleeding is more or even is formed
Hematostaxis phenomenon.Caused by the common cause of bleeding gums is the chronic inflammation by gum, periodontitis and gingivitis patients
It is more common.Dental caries be using bacterium as under chief reason, cause that dental hard tissue occurs that chronic progressive destroys it is a kind of most
For a kind of common mouth disease.The acidic metabolite generated in bacterial metabolism carbohydrate bacterial plaque, can cause enamel
Demineralization, dissolving, and then develop and form dental caries.If therefore energy can effectively control bacterial plaque, can effectively control the occurrence and development of dental caries.
The raw materials for production that existing toothpaste uses are all more traditional, in addition to cleaning tooth, ineffective treatment and prevention canker sore,
The mouth diseases such as bleeding gums, dental caries.
Invention content
Problem to be solved by this invention be to provide it is a kind of containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and
Preparation method can not only clean tooth, but also can prevent mouth disease, and anti-inflammatory is antibacterial, by repairing oral mucosas tissue, improve
Oral mucosa microcirculation, analgesia, promoting blood circulation and hemostasis promote canker sore healing and gum hemostasis, anti-inflammatory.It simultaneously can also be by subtracting
Few plaque bacteria and the acidity of generation reach the prevention pathogenetic effect of dental caries, the effectively occurrence and development of control and anticaries.
To achieve the goals above, the technical solution that the present invention takes is:
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is characterised in that its raw material
Weight percent is:
Propolis extract 0.03~3.2%
Notogineng Extract 0.1~1.5%
Cortex Moutan extract 0.01~0.3%
Coptis extract 0.1~1.5%
Licorice 0.1~1.5%
Natural whiting 20~35%
Silica 8~26%
Glycerine 3~13.5%
Polyethylene glycol-400 1~10%
Sodium pyrophosphate 0.2~1%
Xanthans 0.2~1.5%
Carboxymethyl cellulose 0.1~1.5%
Sorbierite 3~15%
Saccharin sodium 0.1~1%
Lauryl sodium sulfate 1~5%
Nipagin A sodium 0.05~0.5%
Soluble propylhydroxybenzoate 0.02~2%
Essence 0.2~3%
Zinc citrate 0.05~2%
Water surplus.
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae the preparation method of toothpaste include the following steps:
(1) that propolis, Radix Notoginseng, moutan bark, the coptis, licorice be first dissolved in 95% ethyl alcohol is standby as propolis alcoholic solution
With;
(2) sodium pyrophosphate is dissolved in glycerine, then xanthans is well-dispersed in glycerine, then carboxymethyl cellulose is added to fill
It is scattered in glycerine, it is spare;
(3) saccharin sodium, nipagin A sodium, soluble propylhydroxybenzoate are dissolved in water, it is spare;
(4) sorbierite and polyethylene glycol-400 mixing is spare;
(5) silica, natural whiting, lauryl sodium sulfate and zinc citrate are mixed, it is spare;
(6) essence is ready to spare;
(7) standby in above-mentioned steps 2,3,4,5,6 is put into Manufacturing medicine extract machine, in vacuum degree -0.09, start high speed and
Scraper plate stirs evenly 20 minutes at a slow speed, and the propolis alcoholic solution of step 1 is then added, stirs evenly;The lotion in Manufacturing medicine extract machine, to the greatest extent
Amount sucking storage pot is stirred again;Sterilizing, packing.
Advantageous effect:The toothpaste contains the natural nursing tooth-paste of propolis, Radix Notoginseng, moutan bark, the coptis, licorice, right
Gingivitis, bleeding gums, canker sore, halitosis oral peculiar smell etc. have significant curative effect.Propolis, which has, promotes tissue repair, antibacterial suppression
Bacterium, anti-inflammatory, analgesia, hemostasia effect.Radix Notoginseng has promoting blood circulation and hemostasis, antithrombotic, enhancing immune, is effectively improved that mucous membrane of mouth is micro- to follow
Ring.It is moutan bark clearing heat and cooling blood, anti-inflammatory analgesic, promoting blood circulation and removing blood stasis.Coptis clearing away the heart-fire, clearing heat and detoxicating, Anhydroalkannin is antiviral.Radix Glycyrrhizae has
Heat-clearing, removing toxic substances, purging intense heat effect.Therefore containing propolis, Radix Notoginseng, moutan bark, the coptis, licorice in toothpaste simultaneously use so that
The toothpaste analgesic antiphlogistic, resist gingivitis, bleeding gums and pain repair oral cavity mucous membrane tissue, antibacterial anti-halitosis, oral peculiar smell
Effect it is more notable.It can also reach the prevention pathogenetic effect of dental caries by reducing the acidity of plaque bacteria and generation simultaneously,
The effectively occurrence and development of control and anticaries.
Specific implementation mode
Embodiment 1:
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is characterised in that its raw material
Weight percent is:
Propolis extract 0.4%
Notogineng Extract 1.5%
Cortex Moutan extract 0.3%
Coptis extract 1.2%
Licorice 0.5%
Natural whiting 35% (rubbing agent)
Silica 26% (rubbing agent)
Glycerine 3% (moisturizer)
Polyethylene glycol-400 1% (moisturizer)
Sodium pyrophosphate 0.2% (stabilizer)
Xanthans 0.2% (thickener)
Carboxymethyl cellulose 0.1% (stalemate agent)
Sorbierite 3% (moisturizer, detergent, adhesive, sweetener)
Saccharin sodium 0.1% (sweetener)
Lauryl sodium sulfate 1% (foaming agent)
Nipagin A sodium 0.05% (preservative)
Soluble propylhydroxybenzoate 0.02% (preservative)
Essence 0.2% (fumet)
Zinc citrate 0.05% (eliminates bacterial plaque and gingivitis)
Water surplus.
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae the preparation method of toothpaste include the following steps:
(1) that propolis, Radix Notoginseng, moutan bark, the coptis, licorice be first dissolved in 95% ethyl alcohol is standby as propolis alcoholic solution
With;
(2) sodium pyrophosphate is dissolved in glycerine, then xanthans is well-dispersed in glycerine, then carboxymethyl cellulose is added to fill
It is scattered in glycerine, it is spare;
(3) saccharin sodium, nipagin A sodium, soluble propylhydroxybenzoate are dissolved in water, it is spare;
(4) sorbierite and polyethylene glycol-400 mixing is spare;
(5) silica, natural whiting, lauryl sodium sulfate and zinc citrate are mixed, it is spare;
(6) essence is ready to spare;
(7) standby in above-mentioned steps 2,3,4,5,6 is put into Manufacturing medicine extract machine, in vacuum degree -0.09, start high speed and
Scraper plate stirs evenly 20 minutes at a slow speed, and the propolis alcoholic solution of step 1 is then added, stirs evenly;The lotion in Manufacturing medicine extract machine, to the greatest extent
Amount sucking storage pot is stirred again;Sterilizing, packing.
Embodiment 2:
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is characterised in that its raw material
Weight percent is:
Notogineng Extract 0.8%
Propolis extract 1.6%
Cortex Moutan extract 0.09%
Coptis extract 0.3%
Licorice 1.5%
Natural whiting 30% (rubbing agent)
Silica 1 0% (rubbing agent)
Glycerine 10% (moisturizer)
Polyethylene glycol-400 7% (moisturizer)
Sodium pyrophosphate 0.5% (stabilizer)
Xanthans 1.2% (thickener)
Carboxymethyl cellulose 1.3% (stalemate agent)
Sorbierite 15% (moisturizer, detergent, adhesive, sweetener)
Saccharin sodium 0.8% (sweetener)
Lauryl sodium sulfate 3% (foaming agent)
Nipagin A sodium 0.3% (preservative)
Soluble propylhydroxybenzoate 1.2% (preservative)
Essence 1.6% (fumet)
Zinc citrate 1.6% (eliminates bacterial plaque and gingivitis)
Water surplus.
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae the preparation method of toothpaste include the following steps:
(1) that propolis, Radix Notoginseng, moutan bark, the coptis, licorice be first dissolved in 95% ethyl alcohol is standby as propolis alcoholic solution
With;
(2) sodium pyrophosphate is dissolved in glycerine, then xanthans is well-dispersed in glycerine, then carboxymethyl cellulose is added to fill
It is scattered in glycerine, it is spare;
(3) saccharin sodium, nipagin A sodium, soluble propylhydroxybenzoate are dissolved in water, it is spare;
(4) sorbierite and polyethylene glycol-400 mixing is spare;
(5) silica, natural whiting, lauryl sodium sulfate and zinc citrate are mixed, it is spare;
(6) essence is ready to spare;
(7) standby in above-mentioned steps 2,3,4,5,6 is put into Manufacturing medicine extract machine, in vacuum degree -0.09, start high speed and
Scraper plate stirs evenly 20 minutes at a slow speed, and the propolis alcoholic solution of step 1 is then added, stirs evenly;The lotion in Manufacturing medicine extract machine, to the greatest extent
Amount sucking storage pot is stirred again;Sterilizing, packing.
Embodiment 3:
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is characterised in that its raw material
Weight percent is:
Notogineng Extract 1.5%
Propolis extract 3.2%
Cortex Moutan extract 0.03%
Coptis extract 1.5%
Licorice 0.6%
Natural whiting 20% (rubbing agent)
Silica 8% (rubbing agent)
Glycerine 13.5% (moisturizer)
Polyethylene glycol-400 10% (moisturizer)
Sodium pyrophosphate 1.0% (stabilizer)
Xanthans 1.5% (thickener)
Carboxymethyl cellulose 1.5% (stalemate agent)
Sorbierite 10% (moisturizer, detergent, adhesive, sweetener)
Saccharin sodium 1% (sweetener)
Lauryl sodium sulfate 5% (foaming agent)
Nipagin A sodium 0.5% (preservative)
Soluble propylhydroxybenzoate 2% (preservative)
Essence 3% (fumet)
Zinc citrate 2% (eliminates bacterial plaque and gingivitis)
Water surplus.
This contain propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae the preparation method of toothpaste include the following steps:
(1) that propolis, Radix Notoginseng, moutan bark, the coptis, licorice be first dissolved in 95% ethyl alcohol is standby as propolis alcoholic solution
With;
(2) sodium pyrophosphate is dissolved in glycerine, then xanthans is well-dispersed in glycerine, then carboxymethyl cellulose is added to fill
It is scattered in glycerine, it is spare;
(3) saccharin sodium, nipagin A sodium, soluble propylhydroxybenzoate are dissolved in water, it is spare;
(4) sorbierite and polyethylene glycol-400 mixing is spare;
(5) silica, natural whiting, lauryl sodium sulfate and zinc citrate are mixed, it is spare;
(6) essence is ready to spare;
(7) standby in above-mentioned steps 2,3,4,5,6 is put into Manufacturing medicine extract machine, in vacuum degree -0.09, start high speed and
Scraper plate stirs evenly 20 minutes at a slow speed, and the propolis alcoholic solution of step 1 is then added, stirs evenly;The lotion in Manufacturing medicine extract machine, to the greatest extent
Amount sucking storage pot is stirred again;Sterilizing, packing.
Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair
Equivalent structure or equivalent flow shift made by bright specification and embodiment content is applied directly or indirectly in other correlations
Technical field, be included within the scope of the present invention.
Claims (2)
1. it is a kind of containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof, it is characterised in that its raw material
Weight percent is:
Propolis extract 0.03~3.2%
Notogineng Extract 0.1~1.5%
Cortex Moutan extract 0.01~0.3%
Coptis extract 0.1~1.5%
Licorice 0.1~1.5%
Natural whiting 20~35%
Silica 8~26%
Glycerine 3~13.5%
Polyethylene glycol-400 1~10%
Sodium pyrophosphate 0.2~1%
Xanthans 0.2~1.5%
Carboxymethyl cellulose 0.1~1.5%
Sorbierite 3~15%
Saccharin sodium 0.1~1%
Lauryl sodium sulfate 1~5%
Nipagin A sodium 0.05~0.5%
Soluble propylhydroxybenzoate 0.02~2%
Essence 0.2~3%
Zinc citrate 0.05~2%
Water surplus.
A kind of containing propolis, Radix Notoginseng, moutan bark, the coptis, the toothpaste of Radix Glycyrrhizae and its preparation side 2. described in accordance with the claim 1
Method, it is characterised in that:The preparation method of toothpaste containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae includes the following steps:
(1) that propolis, Radix Notoginseng, moutan bark, the coptis, licorice be first dissolved in 95% ethyl alcohol is spare as propolis alcoholic solution;
(2) sodium pyrophosphate is dissolved in glycerine, then xanthans is well-dispersed in glycerine, then carboxymethyl cellulose is added fully to divide
It dissipates in glycerine, it is spare;
(3) saccharin sodium, nipagin A sodium, soluble propylhydroxybenzoate are dissolved in water, it is spare;
(4) sorbierite and polyethylene glycol-400 mixing is spare;
(5) silica, natural whiting, lauryl sodium sulfate and zinc citrate are mixed, it is spare;
(6) essence is ready to spare;
(7) standby in above-mentioned steps 2,3,4,5,6 is put into Manufacturing medicine extract machine, in vacuum degree -0.09, start high speed and at a slow speed
Scraper plate stirs evenly 20 minutes, and the propolis alcoholic solution of step 1 is then added, stirs evenly;The lotion in Manufacturing medicine extract machine, inhale as possible
Enter to store pot and be stirred again;Sterilizing, packing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810795274.2A CN108685833A (en) | 2018-07-16 | 2018-07-16 | Containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810795274.2A CN108685833A (en) | 2018-07-16 | 2018-07-16 | Containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108685833A true CN108685833A (en) | 2018-10-23 |
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|---|---|---|---|
| CN201810795274.2A Pending CN108685833A (en) | 2018-07-16 | 2018-07-16 | Containing propolis, Radix Notoginseng, moutan bark, the coptis, Radix Glycyrrhizae toothpaste and preparation method thereof |
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| CN109846794A (en) * | 2019-01-04 | 2019-06-07 | 无限极（中国）有限公司 | A kind of composition, microballoon comprising the composition and preparation method thereof |
| CN110812316A (en) * | 2019-12-13 | 2020-02-21 | 西安千禾药业股份有限公司 | Toothpaste containing various traditional Chinese medicine compositions, preparation method and application thereof |
| CN111166698A (en) * | 2019-12-30 | 2020-05-19 | 南京中山制药有限公司 | Chinese medicinal toothpaste containing radix et rhizoma Rhei, and its preparation method |
| CN112370413A (en) * | 2020-12-11 | 2021-02-19 | 陈祎 | Toothpaste tube |
| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113476375A (en) * | 2021-08-13 | 2021-10-08 | 陈日和 | Bee venom toothpaste and preparation method thereof |
| CN115531239A (en) * | 2022-05-19 | 2022-12-30 | 海默斯（重庆）医学生物技术有限公司 | Nano-particles, toothpaste and preparation method thereof |
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| CN112569154A (en) * | 2020-12-30 | 2021-03-30 | 柳州两面针股份有限公司 | Plant antibacterial oral care product |
| CN113476375A (en) * | 2021-08-13 | 2021-10-08 | 陈日和 | Bee venom toothpaste and preparation method thereof |
| CN115531239A (en) * | 2022-05-19 | 2022-12-30 | 海默斯（重庆）医学生物技术有限公司 | Nano-particles, toothpaste and preparation method thereof |
| CN115531239B (en) * | 2022-05-19 | 2023-12-12 | 海默斯（重庆）医学生物技术有限公司 | Nanoparticle, toothpaste and preparation method thereof |
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Application publication date: 20181023 |