CN104127586A - Mouth wash capable of inhibiting gum bleeding and preparation method thereof - Google Patents
Mouth wash capable of inhibiting gum bleeding and preparation method thereof Download PDFInfo
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- CN104127586A CN104127586A CN201410394647.7A CN201410394647A CN104127586A CN 104127586 A CN104127586 A CN 104127586A CN 201410394647 A CN201410394647 A CN 201410394647A CN 104127586 A CN104127586 A CN 104127586A
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Abstract
The invention discloses mouth wash capable of inhibiting gum bleeding. Every 100ml of Bodinier's beauty-berry mouth wash comprises the following main components: 6-12g of Bodinier's beauty-berry water extract, 6-9g of euchresta japonica water extract and 3-6g of rhizoma cimicifugae water extract. The mouth wash is low in cost by adopting the traditional Chinese medicines more frequently seen locally as the raw materials. The mouth wash can eliminate food residues and soft mucinous deposits in caveolae, gullets, diastemata, gums, lip cheek grooves and the like of teeth, thus achieving the aims of cleaning oral cavities and inhibiting gum bleeding, and rapidly relieving the phenomenon of gum bleeding.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of collutory that suppresses gingival hemorrhage and preparation method thereof.
Background technology
Gingival hemorrhage is one of department of stomatology common sympton, refers to that gingiva is idiopathic or due to bleeding on a small quantity that minimal irritation causes.Gingival hemorrhage is often with halitosis.The lighter only shows as sucking, brush teeth, while chewing harder food in saliva with the blood streak, severe one is hemorrhage more even hematostaxis in the time that gingiva is subject to minimal irritation.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.Generally, gingival hemorrhage is common in the early stage of periodontitis---gingivitis.Gingival hemorrhage not only comes across the disease of the department of stomatology, it also there will be the Other diseases in whole body, may indicate the disease of other system, as leukemia, meet with after radioactive radiation, autoimmune disease etc., in recent years, the relation of periodontal disease and diabetes is also more and more familiar with by medical circle.
The cause of disease can be divided into local factor and systemic factor.Local factor: the 1. local excitation of bacterial plaque, tartar.The gathering of bacterial plaque, tartar, can, by initiations such as food impaction, bad dummy, bad oral sanitary habits, cause periodontal tissue's inflammation, as bacterial plaque gingivitis, periodontitis etc.2. other local excitation factors (non-bacterial plaque tartar) and bad habit.Under the stimulation of machinery, chemistry, bad dummy, bad obturator, bad appliance and mouth breathing etc., cause local inflammation, as hypertrophy gingivitis, periodontitis etc.3. local organization allergy.When local contact allergy is former, cause anaphylaxis, while involving gingiva, red swelling of gingiva is very easily hemorrhage, as plasma cell gingivitis.4. gingiva injures periodontal surgery outward.Systemic factor: 1. endocrine change.Under the impact that gonadal hormone raises, progesterone hormone raises, make gingiva tissue under minimal irritation, cause nonspecific inflammation, cause gingival hemorrhage, ooze out increase, gingival hyperplasia etc.As pubertal gingivitis, pregnancy gingivitis and epulis.2. systemic disease.As disease in the blood system, diabetes, cardiovascular disease, hepatic and renal function are abnormal, tumor etc.Pathogenic mode normally makes the immunity degradation of whole body, and then causes declining for local irritant resistance, brings out gingivitis; Blood coagulation system obstacle; The organic variation of blood vessel, the kinetics change of blood flow etc.3. some other extraneous factor that acts on whole body.As taking of smoking, anticoagulation medicine etc.Gingival hemorrhage has two kinds of situations, and a kind of situation is to be subject to minimal irritation as brushed teeth, feed, and hemorrhage when sucking waits, this hemorrhage multipotency stops voluntarily, and amount of bleeding is less.Another kind of situation is automatically to bleed when without any stimulation, and amount of bleeding is more, and without self limiting, the former is relevant with situation factor, and the latter is often that systemic factor causes.
Dental plaque in the middle of oral cavity, after Tooth surface forms, as removed not in time, can harden gradually, forms tartar.Tartar multidigit is in the binding site of tooth body and gingiva, this harder tartar produces lasting stimulation for gingiva, when normal gingiva is subject to the stimulation of inflammation, the blood capillary of gingiva increases, become congested, gingiva color is dimmed, once be upset, gingiva is just easily hemorrhage, the reason of Here it is gingival hemorrhage.When periodontitis, not only gingival hemorrhage, and also tooth starts to occur loosening.Common oral cavity theory thinks, gingival hemorrhage is the gingiva tissue C that is deficient in vitamin, and causes growing and break out and causing of a kind of anaerobe, and this saying just makes an explanation from superficial phenomenon, does not in fact find the root of problem.Modern physiological Study discovery, gingival hemorrhage is the too early physiology degradation phenomena of the one of gingiva tissue, then causes gingiva auxotrophy.In addition also have many health care theories to think, gingival hemorrhage is to cause by getting angry.
At present, the medicine that suppresses gingival hemorrhage also has a lot, for the problems referred to above, publication number 102871854A(application number 201210338497.9) patent a kind of toothpaste that prevents gingival hemorrhage is disclosed, it is to be formed for phenyl two guanidine radicals hexanes and deionized water mixed preparing by calcium carbonate, calcium hydrosilicate three water salt, calcium hydrogen phosphate anhydrous salt, hydronium(ion) oxidation sodium, aluminium hydroxide, citric acid, Mentholum, sodium lauryl sulfonate, sodium carbonate, spice, xylitol, dioxygen, and the weight portion of described each component is: calcium carbonate: 10-15 part; Calcium hydrosilicate three water salt: 10-15 part; Calcium hydrogen phosphate anhydrous salt: 1-1.5 part; Hydronium(ion) oxidation sodium: 20-30 part; Aluminium hydroxide: 6-10 part; Citric acid: 4-6 part; Mentholum: 4-6 part; Sodium lauryl sulfonate: 0.5-1.5 part; Sodium carbonate: 0.5-1.5 part; Spice: 1-2 part; Xylitol: 0.1-0.5 part; Dioxygen is for phenyl two guanidine radicals: 4-6 part; Deionized water: 30-40 part.Publication number 103599420A(application number 201310626251.6) patent a kind of Chinese medicine composition for the treatment of gingival hemorrhage is disclosed, component by following weight parts forms: Rhizoma Coptidis 20-30 part, Herba Menthae 20-30 part, Herba Houttuyniae 20-30 part, Radix Rehmanniae 20-30 part, Herba Lophatheri 20-30 part, Fructus Gardeniae 20-30 part, Radix Isatidis 10-20 part, Lignum Aquilariae Resinatum 10-20 part, Semen Raphani 10-20 part, Fructus Forsythiae 10-20 part, Cortex Moutan 10-20 part, 10-20 parts of Flos Loniceraes, Radix Ophiopogonis 1-10 part, Folium Callicarpae Formosanae 1-10 part, Rhizoma Phragmitis 1-10 part, Radix Arnebiae (Radix Lithospermi) 1-10 part, Herba Andrographis 1-10 part, Aloe 1-10 part, Folium Nelumbinis 1-10 part.Publication number 101780229A(application number 201010151148.7) patent a kind of Chinese medicine composition for the treatment of gingival hemorrhage and preparation method thereof is disclosed, mainly formed by the crude drug of following weight portion: Rhizoma Coptidis 1-100 part, Radix Scutellariae 1-100 part, Radix Trichosanthis 1-150 part, Gypsum Fibrosum 1-100 part, Rhizoma Anemarrhenae 1-100 part, Rhizoma Phragmitis 1-100 part, Herba Lophatheri 1-100 part, Fructus Gardeniae 1-100 part, Lignum Aquilariae Resinatum 1-50 part, Lignum Dalbergiae Odoriferae 1-50 part, Semen Raphani 1-100 part, Radix Rehmanniae 1-100 part, Fructus Forsythiae 1-100 part, Herba Taraxaci 1-100 part, Herba Violae 1-100 part, Radix Scrophulariae 1-100 part, Cortex Moutan 1-100 part, Radix Paeoniae Rubra 1-100 part, Radix Arnebiae (Radix Lithospermi) 1-100 part, Herba Houttuyniae 1-50 part, Flos Lonicerae 1-100 part, Rhizoma Smilacis Glabrae 1-100 part, Herba Andrographis 1-50 part, Herba Artemisiae Annuae 1-50 part, Radix Cynanchi Atrati 1-50 part, Cortex Lycii 1-100 part, Radix Stellariae 1-50 part, Rhizoma Picrorhizae 1-50 part, Radix Et Rhizoma Rhei 1-50 part, Aloe 1-50 part, Semen Pruni 1-50 part, Massa Medicata Fermentata 1-120 part.Though treating of gingival hemorrhage had to certain curative effect to a certain extent, generally speaking, the clinical cure rate of these medicines is lower, and some medicine also has toxic and side effects to patient.
Summary of the invention
For the deficiencies in the prior art, the present invention further probes on the basis of existing technology, provides a kind of technique simple, with low cost, and medicament sources suppresses the collutory of gingival hemorrhage widely.One of object of the present invention is to provide a kind of collutory that suppresses gingival hemorrhage, there is antiinflammatory, hemostasis, the effect of sterilization, can dispose food debris and soft dirt that alveole ditch, diastema, gingiva, lip buccal groove of remaining in tooth etc. are located, intraoral bacterial number is reduced relatively, thereby reach cleaning oral cavity and suppress the object of gingival hemorrhage, phenomenon that can rapid recovery gingival hemorrhage.Another object of the present invention is just to provide the preparation method of above-mentioned collutory.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Suppress the collutory of gingival hemorrhage, the main component of every 100ml collutory: 6-12g(is preferred for Folium Callicarpae Formosanae water extract, Folium Callicarpae Formosanae water extract 7-10g, is more preferably, Folium Callicarpae Formosanae water extract 9g), Radix Sophorae Tonkinensis water extract 6-9g, Rhizoma Cimicifugae water extract 3-6g.
Suppress the collutory of gingival hemorrhage, preferably scheme is, the main component of every 100ml collutory: Folium Callicarpae Formosanae water extract 8-10g, Radix Sophorae Tonkinensis water extract 7-8g, Rhizoma Cimicifugae water extract 4-5g.
Suppress the collutory of gingival hemorrhage, the scheme being more preferably is, the main component of every 100ml collutory: Folium Callicarpae Formosanae water extract 9g, Radix Sophorae Tonkinensis water extract 7.5g, Rhizoma Cimicifugae water extract 4.5g.
The preparation method of the collutory of above-mentioned inhibition gingival hemorrhage, step is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked to 1-2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1-2 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, mix homogeneously, sterilizing, sterile packaged.
According to preparation method recited above: step (1) amount of water be advisable to soak medicated powder 3-5cm (preferably, amount of water was to soak medicated powder 4cm).
According to preparation method recited above: step (1) is dried (preferably, drying at 700 DEG C) at 600 DEG C-800 DEG C.
According to preparation method recited above: step (2) adds the ethanol that is equivalent to 4-6 times of quality of Folium Callicarpae Formosanae coarse powder, (preferably, adding the ethanol that is equivalent to 5 times of quality of Folium Callicarpae Formosanae coarse powder).
According to preparation method recited above: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (2).
According to preparation method recited above: step (2) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, be concentrated into relative density and be 1.3 thick paste).
According to preparation method recited above: step (3) sterilizing at 80 DEG C-120 DEG C (preferably, sterilizing at 100 DEG C).
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
The pharmacological effect of each crude drug is respectively:
Folium Callicarpae Formosanae: acrid in the mouth, hardship, property is flat.Return liver, spleen, stomach warp.There is dissipating blood stasis hemostasis, effect of reducing swelling and alleviating pain.Folium Callicarpae Formosanae bitter in the mouth, puckery, the property of medicine are flat, have the function of hemostasis, dissipating blood stasis, antiinflammatory.Leaves contains a kind of hemostatic compositions that is referred to as flavonoid condensed tannin, so have effect of hemostasis, dissipating blood stasis, antiinflammatory.With the formulated injection of Folium Callicarpae Formosanae extract, the hemorrhage and postoperative hemorrhage of otch while can be used for treating gastrointestinal hemorrhage, surgical operation.Leaf is mainly used in spitting blood, spitting of blood, and epistaxis, has blood in stool; External curing traumatic hemorrhage.Root is mainly used in treating swelling and pain by traumatic injury, rheumatic ostalgia.Can astringing to arrest bleeding, again can cooling blood for hemostasis, be applicable to various interior traumatic hemorrhage, be especially used for lung gastrorrhagia.Folium Callicarpae Formosanae, except having anastalsis, still has good anti-anti-infectious function and astriction, tries out in burning, scald texts also better.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature.Attach to the lung and stomach meridians.For the dry root and rhizome of leguminous plant Sophora tonkinensis Gagnep..There is heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain.Pent up laryngopharynx swelling and pain, gingivitis, throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention for fire-toxin.
Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature.For the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.Return lung, spleen, stomach, large intestine channel.There is the rash of delivering, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome is sent out speckle, proctoptosis, uterine prolapse.
The present invention is summing up on the basis of forefathers' experience, adopts pure natural draft Chinese medicine unique formula and technique to refine and forms, and adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.There is antiinflammatory, pain relieving, the effect of sterilization, inhibition gingival hemorrhage.
Technical advantage of the present invention is also embodied in:
1, selected materials is Chinese medicine material, has no side effect;
2, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Brief description of the drawings
Fig. 1 uses embodiment 5 gained to suppress gingival hemorrhage situation after the collutory of gingival hemorrhages;
Fig. 2 uses embodiment 5 gained to suppress diet situation after the collutory of gingival hemorrhages.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the preparation process of the collutory of inhibition gingival hemorrhage is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked 1 day, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, control the main component of the every 100ml of collutory of the inhibition gingival hemorrhage of gained: Folium Callicarpae Formosanae water extract 6g, Radix Sophorae Tonkinensis water extract 6g, Rhizoma Cimicifugae water extract 3g, mix homogeneously, sterilizing, sterile packaged.
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
embodiment 2the preparation process of the collutory of inhibition gingival hemorrhage is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, control the main component of the every 100ml of collutory of the inhibition gingival hemorrhage of gained: Folium Callicarpae Formosanae water extract 12g, Radix Sophorae Tonkinensis water extract 9g, Rhizoma Cimicifugae water extract 6g, mix homogeneously, sterilizing, sterile packaged.
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
model case one:cao XX, female, 21 years old, people from Liaocheng of Shandong Province.Main suit: lower labial teeth place often has pus to overflow more than January.History of present illness: patient is hemorrhage when gingiva is brushed teeth often in this year, has halitosis.Nearly lower labial teeth in January place has pyorrhea to go out requirement diagnosis and treatment.History of past illness: inquiry patient denies great illness history and hematologic disease history.Check: bottom right 12 lower-left 12 malalinements, tartar 2 is spent, and red swelling of gingiva leans out blood, and the dark about 4-5mm of week bag, has pus, loosening 1 degree.X-ray inspection AQL absorbs and reaches long 1/3 left and right of root.Diagnosis: bottom right 12 lower-left 12 adult periodontitises.Another diagnosis: have gingivitis, form without periodontal pocket, without frontal resorption, without typical periodontitis clinical manifestations such as odontoseisiies.
1 course for the treatment of of collutory that uses embodiment 2 gained to suppress gingival hemorrhage is used 20ml at every turn, tells every day 3 times after gargling 2 minutes.The symptom that gingiva place pus overflows is eased, and gingival hemorrhage also obviously alleviates, and self-induction halitosis symptom alleviates.1 course for the treatment of of collutory of continuing to use embodiment 2 gained, the phenomenon that gingival hemorrhage comes to a head disappears substantially.See this curative effect, Mrs Cao is very excited, holds on and consolidates the state of an illness 1 course for the treatment of with this collutory, and self-induction is fully recovered.In the following up a case by regular visits to of later stage, learn, Mrs Cao fully recovers.
embodiment 3the preparation process of the collutory of inhibition gingival hemorrhage is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, control the main component of the every 100ml of collutory of the inhibition gingival hemorrhage of gained: Folium Callicarpae Formosanae water extract 8g, Radix Sophorae Tonkinensis water extract 7g, Rhizoma Cimicifugae water extract 4g, mix homogeneously, sterilizing, sterile packaged.
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
embodiment 4the preparation process of the collutory of inhibition gingival hemorrhage is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, control the main component of the every 100ml of collutory of the inhibition gingival hemorrhage of gained: Folium Callicarpae Formosanae water extract 10g, Radix Sophorae Tonkinensis water extract 8g, Rhizoma Cimicifugae water extract 5g, mix homogeneously, sterilizing, sterile packaged.
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
model case two:open XX, man, 29 years old, people from Zibo City of Shandong Province.When patient haves a medical check-up, be diagnosed as " periodontitis ", while brushing teeth, gingival hemorrhage 5 years, conscious of halitosis, and idol has spontaneous hemorrhage, brushes teeth every day 2 times, and non-smoking history, without periodontal treatment history.Check: poor oral hygiene, tartar (++-+++), gingiva color is red, and matter is soft, BI3-4.Labial teeth PD3-5mm, backteeth, PD5-9mm, 16 26 III ° are become flexible, gingival recession 3-4mm, PD 7-9 mm, FI12 °-3 °, 16 periodontal pyorrheas.41 III ° are loosening, PD6-8mm, and gingival recession 2mm, center is closed and is early contacted with protracting to have closed.36 37 46 47 I °-II is ° loosening, PD7-9mm, FI2 °.History of past illness and family history are without special, and systemic conditions is good.X sheet checks: dental pattern groove bone bone ridge backform is stuck with paste, and bone hardboard disappears.41 frontal resorption are to the tip of a root 1/3rd, the film broadening of root week.16 and 26 cheek side alveolar bones extensively absorb to the tip of a root, and palate side frontal resorption is to the tip of a root 1/4th.46 alveolar bone arcs are capable to be absorbed to the tip of a root 1/3rd, the film broadening of root week, furcation area shade.Remaining tooth frontal resorption is to the tip of a root 1/3rd to 1/2nd.Doctor gives oral cephalo, VC, and VB, every day 3 times, continuous use about 1 week, bleeding is inhibited, and, after a wheat harvesting period, gingiva is still hemorrhage.
In the time that Mr. Zhang is hopeless, listen unintentionally colleague to introduce the present invention for suppressing the collutory of gingival hemorrhage, so use embodiment 4 gained to suppress after the course for the treatment of of collutory of gingival hemorrhages, gingival hemorrhage phenomenon obviously alleviates, see this curative effect, Mr. Zhang continues to use 2 courses for the treatment of of collutory of embodiment 4 gained, and gingival hemorrhage phenomenon disappears, and self-induction odontoseisis phenomenon also improves.Later stage learns that the phenomenon of Mr. Zhang's gingival hemorrhage is fully recovered in following up a case by regular visits to.
embodiment 5the preparation process of the collutory of inhibition gingival hemorrhage is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked 2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder.
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, control the main component of the every 100ml of collutory of the inhibition gingival hemorrhage of gained: Folium Callicarpae Formosanae water extract 9g, Radix Sophorae Tonkinensis water extract 7.5g, Rhizoma Cimicifugae water extract 4.5g, mix homogeneously, sterilizing, sterile packaged.
Using method: use 10-20ml at every turn, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity, tell after preferably gargling 2 minutes at every turn.Every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.
test example:in order to verify that embodiment 5 gained suppress the collutory of gingival hemorrhage, we have carried out contrast test.Gingival hemorrhage patient 300 people are selected in experiment, are divided into randomly matched group and experimental group, and every group number is identical, is respectively 150 people.With observation post administration and record patient's gingival hemorrhage situation.Experimental group: the collutory that uses the inhibition gingival hemorrhage of embodiment 5 gained, each 10-20ml that uses, collutory is contained in mouth, then agitate two cheeks and lip, solution is fully contacted with tooth in oral cavity, and utilize waterpower to rinse repeatedly each position, oral cavity collutory is contained in mouth, after gargling 2 minutes, tell at every turn, every day 3-5 time, three use after the meal and before sleep, within 2 days, are a course for the treatment of.Matched group: adopt other treatment scheme, such as oral amoxicillin, tinidazole, VB2, VC etc.Wherein criterion of therapeutical effect: cure: gingival hemorrhage symptom disappears completely; Effective: gingival hemorrhage symptom part disappears; Invalid: gingival hemorrhage symptom is without alleviating and recurrence in 1 month.Wherein effectively comprise healing and effective.
Observation period was limited to for 3 courses for the treatment of, and observed content is as follows:
1, observed once every 2 days, record the situation of gingival hemorrhage symptom, add up the number of each course for the treatment of of bleeding recovery from illness, result is as accompanying drawing 1:
Analyze: from accompanying drawing 1, can find out, the collutory of the inhibition gingival hemorrhage of embodiment 5 gained, has good mitigation to bleeding, more than the good effect that adopts other treatment scheme.
2, observed once every 2 days, record diet situation, add up the number that each course for the treatment of, diet situation was improved, result is as accompanying drawing 2:
Analyze: from accompanying drawing 2, can find out, the collutory of the inhibition gingival hemorrhage of embodiment 5 gained, has good improvement effect to appetite, more than the good effect that adopts other treatment scheme.
3, matched group oral western medicine and experimental group use the collutory of the inhibition gingival hemorrhage of embodiment 5 gained to obtain Comparison of therapeutic, and result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, use the embodiment of the present invention 5 gained suppress gingival hemorrhages collutory only have 2 people invalid, and adopt other treatment scheme have 12 people invalid.And using the cure rate of collutory that embodiment 5 gained suppress gingival hemorrhages up to 92.7%, effective percentage has reached 98.7%, adopts the cure rate of other treatment scheme only to reach 68%, comparatively speaking, uses the cure rate of collutory of the present embodiment 5 higher, more reliable.Experiment show to use embodiment 5 gained suppress gingival hemorrhages collutory experimental group and adopt compared with the matched group of other treatment scheme, its curative effect increases substantially, and cure rate significantly promotes, and inefficiency is low, has reduced potential risks.
Can find out from accompanying drawing 1-2, the experimental group of the collutory of use embodiment 5 gained inhibition gingival hemorrhages and the matched group of employing other treatment scheme are in 3 courses for the treatment of of observation period, what use collutory has up to more than 97% patient's self-induction symptom recovery from illness, and adopt more than 75% sensory symptoms that only has of other treatment scheme to fully recover, so can find out, use embodiment 5 gained to suppress the more remarkable treatment effect of the collutory of gingival hemorrhage.And can significantly find out, the collutory of the inhibition gingival hemorrhage of embodiment 5 gained just has the patient's who exceedes 2/3 symptom to be eased the 1st course for the treatment of, and curative effect is faster, subtracts the slight illness that has greatly alleviated patient.Prove through clinical trial, the collutory that the present invention suppresses gingival hemorrhage has antiinflammatory, hemostasis, the effect of sterilization, can dispose simultaneously and remain in food debris and the soft dirt that the alveole ditch, diastema, gingiva, lip buccal groove etc. of tooth are located, thereby reach cleaning oral cavity and suppress the object of gingival hemorrhage, phenomenon that can rapid recovery gingival hemorrhage.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the collutory that suppresses gingival hemorrhage, is characterized in that the main component of every 100ml collutory: Folium Callicarpae Formosanae water extract 6-12g, Radix Sophorae Tonkinensis water extract 6-9g, Rhizoma Cimicifugae water extract 3-6g.
2. collutory according to claim 1, is characterized in that, the main component of every 100ml collutory: Folium Callicarpae Formosanae water extract 8-10g, Radix Sophorae Tonkinensis water extract 7-8g, Rhizoma Cimicifugae water extract 4-5g.
3. collutory according to claim 1, is characterized in that, the main component of every 100ml collutory: Folium Callicarpae Formosanae water extract 9g, Radix Sophorae Tonkinensis water extract 7.5g, Rhizoma Cimicifugae water extract 4.5g.
4. according to the preparation method of the arbitrary described collutory of claim 1-3, it is characterized in that, step is as follows:
(1) respectively Radix Sophorae Tonkinensis and Rhizoma Cimicifugae are soaked to 1-2 days, be placed in marmite, decoct with water twice, boil 1 hour at every turn, twice filtrate merges, concentrated, dries, and obtains respectively Radix Sophorae Tonkinensis water extract and Rhizoma Cimicifugae water extract;
(2) Folium Callicarpae Formosanae is made to coarse powder, water extraction twice is boiled 1-2 hour at every turn, and twice filtrate merges, and is concentrated into thick paste shape, add ethanol, fully stir, washing, puts on cloth formula funnel and separates, discard ethanol mother solution, precipitation, 60 DEG C of following being dried, obtains Folium Callicarpae Formosanae water extract dry powder;
(3) step (1) and step (2) gains are placed in to glass container, add distilled water, mix homogeneously, sterilizing, sterile packaged.
5. the preparation method of collutory according to claim 4, is characterized in that: step (1) amount of water was advisable to soak medicated powder 3-5cm (preferably, amount of water was to soak medicated powder 4cm).
6. the preparation method of collutory according to claim 4, is characterized in that: step (1) is dried (preferably, at 700 DEG C, drying) at 600 DEG C-800 DEG C.
7. the preparation method of collutory according to claim 4, is characterized in that: step (2) adds the ethanol that is equivalent to 4-6 times of quality of Folium Callicarpae Formosanae coarse powder, (preferably, adding the ethanol that is equivalent to 5 times of quality of Folium Callicarpae Formosanae coarse powder).
8. the preparation method of collutory according to claim 4, is characterized in that: the preferred Callicarpa nudiflora of Folium Callicarpae Formosanae, Callicarpa lobo-apiculata Metc. or the Folium Callicarpae Macrophyllae described in step (2).
9. the preparation method of collutory according to claim 4, is characterized in that: step (2) is concentrated into the thick paste that relative density is 1.2-1.4 (preferably, be concentrated into relative density and be 1.3 thick paste).
10. the preparation method of collutory according to claim 4, is characterized in that: step (3) sterilizing at 80 DEG C-120 DEG C (preferably, sterilizing at 100 DEG C).
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| CN104739742A (en) * | 2015-03-04 | 2015-07-01 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine mouth wash for treating gum bleeding and preparation method of traditional Chinese medicine mouth wash |
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| CN109329587A (en) * | 2018-12-26 | 2019-02-15 | 湖北中博绿亚生物技术有限公司 | The food additives and preparation method thereof that dog cat eliminates bad breath |
| CN113398040A (en) * | 2021-08-07 | 2021-09-17 | 兰州市食品药品检验检测研究院 | Mouthwash as well as preparation method and use method thereof |
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