CN104983744A - Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products - Google Patents
Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products Download PDFInfo
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- CN104983744A CN104983744A CN201510377497.3A CN201510377497A CN104983744A CN 104983744 A CN104983744 A CN 104983744A CN 201510377497 A CN201510377497 A CN 201510377497A CN 104983744 A CN104983744 A CN 104983744A
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Abstract
The invention relates to an oral care composition containing periplaneta americana, oral care products and preparation methods of the oral care composition and the oral care products. The composition mainly comprises the following raw materials in parts by mass: 0.1-20 parts of periplaneta americana extractive and 0.1-5 parts of sylvite; the oral care products comprise toothpaste, mouthwash, tooth gel, tooth paste or a tooth paste preparation, tooth powder, chewing gum, and the like, which all comprise the oral care composition containing periplaneta americana. The invention provides the oral care composition containing periplaneta americana good in dental ulcer treating and tooth sensitivity resisting effects, the oral care products and preparation methods of the oral care composition and the oral care products.
Description
Technical field
The present invention relates to a kind of oral care composition containing treating oral ulcer and anti-sensitivity of tooth component, specifically, is the oral care composition of American-cockroach-extract-containing, potassium salt, tranamic acid, oral-cavity article and preparation method thereof.
Background technology
Common oral disease comprises oral ulcer, periodontal disease, dental caries.Oral ulcer is divided into Catarrhal, aphthous, vesicle, phlegmonous, the type such as pseudomembranous, exedens and papular clinically, its common clinical symptoms all show as sialorrhea, inappetence or search for food slowly, oral malodor, oral mucosa flushing, heat, swelling and pain.Periodontal disease mainly refers to gingivitis and periodontitis; Gingivitis refers to acute, the chronic inflammatory disease that occur in gingiva tissue, common manifestation is gingival hemorrhage, red and swollen, distending pain, also can cause the recurrent exerbation of oral ulcer, both also can interact, and form vicious cycle, if do not carry out effectively treatment likely cause periodontitis to Deep Development, cause the problem that odontoseisis, loss of tooth etc. are more serious.Periodontitis is the chronic inflammatory disease invading gingiva and periodontal tissue, is a kind of destructive disease, many because bacterial plaque, tartar, food impaction, ill fitting prosthesis, stings wound etc. and causes various focusing depths represented swelling, makes bacterial plaque pile up simultaneously and increases the weight of, and prolong by expanding under gingivally on gum.Due to the feature of microecological environment under gum, the Periodontal Pathogens that virulence is larger is in a large number grown in subgingival plaque, as gingiva bacteroid, intermediate bacillus, spirillums etc., make the increased inflammation of gingiva and expand to prolong, cause periodontal pocket to be formed and frontal resorption, cause periodontitis, so the main inducing of periodontitis is also because the accumulation of dental plaque causes.
Sensitivity of tooth, that tooth is being subject to environmental stimuli, symptom of aching as caused in temperature (hot and cold), chemical substance (sour, sweet) and mechanism (rub or sting hard object) etc., its feature is for outbreak is rapid, pain is sharp-pointed, the time is of short duration.All enamel integrity that can make are damaged, the various dental diseases that dentin exposes, and dentin hypersensitivity all can occur, i.e. sensitivity of tooth as abrasion, wedge shaped defect, odontagma, dental caries and periodontal atrophy cause neck portion exposure etc.Dental hypersensitivity often annoyings the life of people, and severe patient also can cause other diseases such as oral cavity, heart.
Periplaneta americana is a kind of traditional pharmaceutical insects, and be Blattaria Blattidae Periplaneta insecticide, research shows, periplaneta americana has and promotes blood vessel hyperplasia, tissue repair, strengthening heart and boosting pressure, improves microcirculation, antimicrobial antiphlogistic, antiviral, antitumor, strengthens the effects such as immunity, can be used for skin, oral cavity.Porphyromonas gingivalis is the periodontal disease especially topmost dominant bacteria of adult periodontitis's diseased region, and the medicine of periodontal disease must suppress periodontal pathogen effectively, and Hu Shaopeng etc. confirm that American-cockroach-extract effectively can suppress the growth of porphyromonas gingivalis.Xiao little Qin etc. also demonstrate that American-cockroach-extract has obvious inhibitory action to the tissue edema that inflammation causes with oozing out, and have significant analgesic activity, have anti-inflammation detumescence effect.And the extraction process of American-cockroach-extract is ripe, it also has gratifying prospect in the preventing and treating of periodontal, and can be used for treating stomatitis, oral ulcer, alveolus dry socket, exodontia complication, periodontitis, chronic periapical periodontitis etc.Such as: publication number is CN103083363A, name is called a kind of preparation method of American-cockroach-extract and the Chinese patent of novelty teabag, then disclose the method for preparing extractive of periplaneta americana, the Chinese patent that publication number is CN101837019A, name is called a kind of American cockroach medicament composition for the treatment of oral ulcer and preparation method thereof, the proportioning then disclosing periplaneta americana and metronidazole combines, and also has more patent and document to disclose the preparation about periplaneta americana and the application in oral ulcer thereof.
The report of the anti-sensitivity of tooth of potassium salt is a lot, as publication number be CN1528260, name is called the Chinese patent of the double antianaphylaxis tooth paste containing potassium salt and strontium salt, disclose potassium salt for the application in antianaphylactic toothpaste, its mechanism of action can reduce Dentinal permeability because potassium ion enters Dentinal tubule, and have affinity interaction with teleneuron, improve the transmission of Nerve impulse.In the process of brushing teeth with potassium nitrate toothpaste, the potassium ion in potassium nitrate can discharge from toothpaste, enters into dentinal tubule, and passes through the signal of inhibition of Chemical Reaction teleneuron conducting pain, thus reaches lenitive object.If use a period of time continuously, potassium ion in dentinal tubule can be made to reach certain dynamic equilibrium, and effect is continuous and effective more.
Tranamic acid is white crystalline powder, odorless, mildly bitter flavor, and be a kind of hemorrhage, its hemostatic mechanism is identical with aminocaproic acid, and haemostatic effect comparatively aminocaproic acid is strong 5-10 times.It is reported that fibrinoclase and periodontal have close contacting, along with increasing the weight of of periodontal disease, fibrinoclase also increases thereupon.Tranamic acid is a kind of preparation of fibrinolysis enzyme, has antagonism to said process, is thus applied to abnormal bleeding when preventing and reduce operation, and the sick and hemophiliac periodontal scaling of purple paralysis is front.Also people is had to add in toothpaste by tranamic acid, obtain the effect alleviating gingival hemorrhage, Luan Qing first waits and has done Clinical evaluation to containing tranamic acid toothpaste, the effect alleviating gingival hemorrhage can be played, such as, the Chinese patent that publication number is CN103027873A, name is called a kind of anti-inflammatory hemostatic toothpaste, discloses the effect of tranamic acid for stopping blooding in toothpaste.
In oral-cavity article, add separately periplaneta americana only can have certain help to oral ulcer, adding separately potassium salt can only have certain help to antiallergic, adds separately tranamic acid and also only can play certain anastalsis.But gingivitis, often along with gingival hemorrhage, if can not treat gingivitis in time, will cause the recurrent exerbation of oral ulcer, and the gingival atrophy that gingivitis causes, can Root exposnre be made, cause sensitivity of tooth, cause multiple oral problem.American-cockroach-extract has good muscular tissue repairing activity to various traumatic surface and body ulcer, the healing of oral ulcer can be promoted, it has antibiotic property simultaneously, effectively can safeguard gums healthy, but it does not have hemostatic function, tranamic acid add the anti-microbial property that can coordinate American-cockroach-extract, safeguard gums healthy better, avoid the vicious cycle of oral ulcer and gingivitis.Potassium salt can suppress the signal of teleneuron conducting pain, alleviating pain, the while of antianaphylactic, alleviates the pain that periodontal problems causes.So American-cockroach-extract, potassium salt and tranamic acid can play effect jointly, solve the problem such as gingival hemorrhage, sensitivity of tooth, oral ulcer recurrent exerbation that gingivitis causes, thus improve ulcer healing rate, shorten healing.Therefore, inventor by periplaneta americana, potassium salt composition, after periplaneta americana, potassium salt, tranamic acid compositions proportioning, make toothpaste, find make toothpaste time and good stability, time and poor stability, and effective during the effect of antiallergic, treatment oral ulcer, time and effect is poor; Stability then refers to, toothpaste remains closely, fine and smooth and evenly, can not have to be separated water outlet, dry and hardly to harden and the generation of the phenomenon such as flatulence.As can be seen here, if can by American-cockroach-extract, potassium salt, tranamic acid according to a certain ratio with the use of, and proportion relation etc. it between composite by adjustment moisturizing system, binding agent simultaneously, the effect for the treatment of oral ulcer, gingivitis and anti-sensitivity of tooth can be realized, solve the problem of high salt oral-cavity article poor stability.
The present invention by adding American-cockroach-extract, potassium salt, tranamic acid, reach mutually supplement, object collaborative each other, play prevention and therapy oral ulcer, periodontitis, sensitivity of tooth, effect that red swelling of gingiva is hemorrhage.Up to now, at home and abroad there is no report about American-cockroach-extract, potassium salt, the application of tranamic acid compositions in the oral-cavity article such as toothpaste, collutory.
Summary of the invention
The technical problem to be solved in the present invention be to provide a kind of treat oral ulcer, gingivitis and anti-sensitivity of tooth effective containing the oral care composition, oral-cavity article and preparation method thereof of periplaneta americana.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: containing the oral care composition of periplaneta americana, its raw material is primarily of American-cockroach-extract, potassium salt composition, and its raw materials quality number is: American-cockroach-extract 0.1 ~ 20 part; Potassium salt 0.1 ~ 5 part.
Adopt technical solution of the present invention containing the oral care composition of periplaneta americana, American-cockroach-extract mainly plays the effect for the treatment of oral ulcer and periodontitis, suppression oral cavity bacterium; Potassium salt mainly plays the effect of prevention and therapy sensitivity of tooth.Both are with after aforementioned proportion mixing, and the additive made, is added in oral-cavity article, and it treats the effective of oral ulcer, gingivitis and anti-sensitivity of tooth.
Preferably, described raw material also has tranamic acid, and the mass fraction of each raw material is: American-cockroach-extract 0.1 ~ 20 part; Potassium salt 0.1 ~ 5 part; Tranamic acid 0.01 ~ 0.1 part.Tranamic acid mainly plays alleviates the effect of gingival hemorrhage, on the basis for the treatment of oral ulcer, gingivitis, plays anastalsis, avoids gingival hemorrhage, the mass fraction of each raw material with said ratio, its better effects if.
Preferably, the mass fraction of described raw material is: American-cockroach-extract 0.5 ~ 10 part; Potassium salt 0.3 ~ 5 part.It is in toothpaste, and stability is better.
Preferably, the mass fraction of described raw material is: American-cockroach-extract 0.5 ~ 10 part; Potassium salt 0.3 ~ 5 part; Tranamic acid 0.015 part.It is in toothpaste, and stability is better.
Preferably, described American-cockroach-extract comprises one or more mixture in the water extract of periplaneta americana different parts or alcohol extract, periplaneta americana fine powder.
Containing the oral-cavity article of the oral care composition of periplaneta americana, comprise toothpaste, collutory, dentifrice, tooth paste or ointment preparation, tooth gel and chewing gum.
Preferably, the raw materials quality number of the oral care composition in described toothpaste is: American-cockroach-extract 6 parts; Potassium salt 5 parts; Tranamic acid 0.015 part.In toothpaste, its best results, optimal stability.
Preferably, the raw materials quality number of the oral care composition in described collutory is: American-cockroach-extract 5 parts; Potassium salt 1 part; Tranamic acid 0.015 part.In collutory, its best results.
Preferably, in the raw material composition of described toothpaste, wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water is comprised.
Preferably, in the raw material composition of described collutory, wetting agent, water, surfactant, sweeting agent, two full gear ethanol, emulsifying agent, essence is also comprised.
Containing the preparation method of toothpaste in the oral-cavity article of the oral care composition of periplaneta americana, first wetting agent is added, add binding agent rapid stirring homogenizing again, then sweeting agent, American-cockroach-extract, potassium salt, tranamic acid is added successively, add surfactant, antiseptic again, and uniform stirring; Then evacuation adds abrasivus, stirs homogenizing, finally adds essence, and stir homogenizing, degassed, preparation completes.
Detailed description of the invention
One, (1) is containing the composition of each embodiment Raw of toothpaste of the oral care composition of periplaneta americana, potassium salt and quality, and unit is g, as shown in table 1:
Table 1
Comparative example one: without adding American-cockroach-extract and potassium salt;
Comparative example two: be with the difference of embodiment one: the amount of periplaneta americana is 0.4g, the amount of potassium salt is 5.1g;
Comparative example three: be with the difference of embodiment one: the amount of periplaneta americana is 21g, the amount of potassium salt is 0.09g;
Comparative example four: be with the difference of embodiment one: the amount of periplaneta americana is 6g, and potassium salt is 0g;
Comparative example five: be with the difference of embodiment one: the amount of potassium salt is 5g, the amount of periplaneta americana is 0g.
(2) containing composition and the quality of each embodiment Raw of toothpaste of the oral care composition of periplaneta americana, potassium salt, tranamic acid, unit is g, as shown in table 2:
Table 2
Comparative example six: without the toothpaste adding American-cockroach-extract, potassium salt, tranamic acid;
Comparative example seven: be with the difference of embodiment ten: American-cockroach-extract 0.4g, potassium salt 5.1g, tranamic acid 0.015g;
Comparative example eight: be with the difference of embodiment ten: American-cockroach-extract 21g, potassium salt 0.09g, tranamic acid 0.009g;
Comparative example nine: be with the difference of embodiment ten: American-cockroach-extract 20g, potassium salt 0.09g, tranamic acid 0.11g;
Comparative example ten: be with the difference of embodiment ten: American-cockroach-extract 6g, potassium salt 0g, tranamic acid 0g;
Comparative example 11: be with the difference of embodiment ten: American-cockroach-extract 0g, potassium salt 5g, tranamic acid 0g;
Comparative example 12: be with the difference of embodiment ten: American-cockroach-extract 0g, potassium salt 0g, tranamic acid 0.015g;
American-cockroach-extract, what adopt is the water extract of adult bombay canary, certainly, the mixture of any two kinds, three kinds in the water extract of a kind of or adult bombay canary in adult bombay canary alcohol extract, periplaneta americana fine powder, large Lian adult alcohol extract, periplaneta americana fine powder is taked also can, also water extract, the alcohol extract of the different parts such as head, body part, foot of periplaneta americana can be taked, its effect is consistent with the effect of the water extract adding adult bombay canary, before using, filter with 200 eye mesh screens.The preparation method of the water extract of adult bombay canary, adopt first soak, decoct again, rear concentrated mode extracts; The preparation method of the alcohol extract of adult bombay canary, the mode of take alcohol to soak, filtering is extracted.The preparation process of toothpaste is for first to add wetting agent, add binding agent rapid stirring homogenizing again, add the small powders such as sweeting agent, American-cockroach-extract, potassium salt, tranamic acid successively, potassium salt, except using except potassium nitrate, also can use other potassium salt such as potassium chloride, potassium carbonate; Add surfactant, antiseptic again, and uniform stirring; Then evacuation adds abrasivus, stirs homogenizing, finally adds essence, and stir homogenizing, degassed, prepared by mastic.
Certainly, in the mastic preparation of toothpaste, wetting agent can also be used alone the one in glycerol, sorbitol, propylene glycol or Polyethylene Glycol, or uses the mixture of its combination in any, mass fraction also can select other numerical value except 10g, 35g, and numerical range is at 10 ~ 70g; Binding agent can use sodium hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum or carbomer single component or compound, and mass fraction is at 0.1 ~ 10g; Surfactant can use single component or the mixture such as anion, cation, both sexes or non-ionic surface active agent, as the mixture of sodium lauryl sulphate, sodium lauryl sulfate, N-sarcosinate, hydramine, poloxamer etc., sodium lauryl sulphate, sodium lauryl sulfate, amount ranges can be 0.1 ~ 10g; Sweeting agent can use saccharin sodium, it is sweet to sharp teeth, one or more mixing in stevioside, stevioside, xylitol, amount ranges 0.1 ~ 3g, essence can use one or more mixing in Herba Menthae, Oleum Menthae Rotundifoliae, Mentha piperita, anethole, amount ranges 0.1 ~ 5g, antiseptic uses one or more mixture in benzoate, sodium benzoate, methyl hydroxybenzoate, amount ranges 0.1 ~ 2g.More than select to be the routine making toothpaste to select.
Toothpaste shown in his-and-hers watches 1, table 2 and comparative example carry out clinical oral test, choose the people suffering from sensitivity of tooth, oral ulcer, often organize ten people.They use the toothpaste of embodiment one ~ embodiment 17, comparative example one ~ comparative example 12 respectively on the basis of daily habits (brush every day twice tooth), continue one week.
Result is as follows:
(1), the result on trial of embodiment one ~ embodiment nine, comparative example one ~ comparative example five is as shown in table 3:
Table 3
The stability of toothpaste: the stability of embodiment two ~ embodiment six is all better, and do not occur being separated water outlet, dry and hard situation of hardening, slight separation water outlet phenomenon appears in embodiment one, embodiment seven, embodiment eight, embodiment nine, but does not affect use; And water outlet, dry and hard situation of hardening all appear being separated in comparative example two, three, impact uses.
From the stability result of table 3 and toothpaste, we can find out, the therapeutic effect of embodiment one ~ embodiment nine is significantly better than the therapeutic effect of comparative example one ~ comparative example five, optimal stability, the effect of embodiment two ~ embodiment six are best, and the effect of embodiment one, embodiment seven, embodiment eight, embodiment nine is better than comparative example one ~ comparative example five, embodiment one, embodiment seven ~ embodiment nine, although stability is slightly poor, do not affect use.Shown by the result of embodiment four with comparative example four, comparative example five, although the American-cockroach-extract added separately in the comparative example four of adding in toothpaste, comparative example five, the content of potassium salt are all consistent with embodiment four, but result but differs greatly, this just illustrates that American-cockroach-extract, potassium salt composition effectively can treat oral ulcer, alleviate the symptom of sensitivity of tooth, both only with the use of time, best results, and the optimal stability of American-cockroach-extract, the potassium salt toothpaste when the mass fraction scope of embodiment two ~ embodiment six.
(2), as shown in table 4 to the result on trial of embodiment ten ~ embodiment 17, comparative example six ~ comparative example 12:
Table 4
The stability of toothpaste: the stability of embodiment 11 ~ embodiment 15 is all better, and do not occur being separated water outlet, dry and hard situation of hardening, slight separation water outlet phenomenon appears in embodiment ten, embodiment 16, embodiment 17, but does not affect use; And water outlet, dry and hard situation of hardening all appear being separated in comparative example eight ~ comparative example 12, impact uses.
From the stability result of table 4 and toothpaste, we can find out, the therapeutic effect of embodiment ten ~ embodiment 17 is significantly better than the therapeutic effect of comparative example one ~ comparative example five, optimal stability, the effect of embodiment 11 ~ embodiment 15 are best, and the effect of embodiment ten, embodiment 16, embodiment 17 is better than comparative example six ~ comparative example 12, although stability is slightly poor, do not affect use.By embodiment 13 and comparative example ten, comparative example 11, the result of comparative example 12 shows, although the comparative example ten of adding in toothpaste, comparative example 11, the American-cockroach-extract added separately in comparative example 12, potassium salt, the content of tranamic acid is all consistent with embodiment 13, but result but differs greatly, this just illustrates American-cockroach-extract, potassium salt composition effectively can treat oral ulcer, gingivitis, alleviate the symptom of sensitivity of tooth, three only with the use of time, best results, and American-cockroach-extract, potassium salt, the optimal stability of tranamic acid toothpaste when the mass fraction ratio range of embodiment ten ~ embodiment 15.
Can draw from table 3, table 4, toothpaste containing American-cockroach-extract, potassium salt obviously can treat oral ulcer, alleviate teeth sensitive symptoms, and the toothpaste containing American-cockroach-extract, potassium salt, tranamic acid obviously can treat oral ulcer, gingivitis, alleviation teeth sensitive symptoms, and its effect is all effective than un-added toothpaste.
Two, (1) is containing the composition of each embodiment Raw of collutory of the oral care composition of periplaneta americana, potassium salt and quality, and unit is g, as shown in table 5:
Table 5
Comparative example 13: without adding American-cockroach-extract and potassium salt;
Comparative example 14: be with the difference of embodiment one: the amount of periplaneta americana is 0.4g, the amount of potassium salt is 5.1g;
Comparative example 15: be with the difference of embodiment one: the amount of periplaneta americana is 21g, the amount of potassium salt is 0.09g;
Comparative example 16: be with the difference of embodiment one: the amount of periplaneta americana is 5g;
Comparative example 17: be with the difference of embodiment one: the amount of potassium salt is 1g.
(2) containing composition and the quality of each embodiment Raw of collutory of the oral care composition of periplaneta americana, potassium salt, tranamic acid, unit is g, as shown in table 6:
Table 6
Comparative example 18: without the toothpaste adding American-cockroach-extract, potassium salt, tranamic acid;
Comparative example 19: be with the difference of embodiment ten: American-cockroach-extract 0.4g, potassium salt 5.1g, tranamic acid 0.015g;
Comparative example 20: be with the difference of embodiment ten: American-cockroach-extract 21g, potassium salt 0.09g, tranamic acid 0.009g;
Comparative example 21: be with the difference of embodiment ten: American-cockroach-extract 20g, potassium salt 0.09g, tranamic acid 0.11g;
Comparative example 22: be with the difference of embodiment ten: American-cockroach-extract 6g, potassium salt 0g, tranamic acid 0g;
Comparative example 23: be with the difference of embodiment ten: American-cockroach-extract 0g, potassium salt 5g, tranamic acid 0g;
Comparative example 24: be with the difference of embodiment ten: American-cockroach-extract 0g, potassium salt 0g, tranamic acid 0.015g;
American-cockroach-extract, what adopt is the water extract of adult bombay canary, certainly, the mixture of any two kinds, three kinds in the water extract of a kind of or adult bombay canary in adult bombay canary alcohol extract, periplaneta americana fine powder, large Lian adult alcohol extract, periplaneta americana fine powder is taked also can, also can take water extract, the alcohol extract of the different parts such as head, body part, foot of periplaneta americana, its effect is consistent with the effect of the water extract adding adult bombay canary.Sieve with 200 eye mesh screens before preparation, avoid residue to enter in collutory.The preparation process of collutory, for first wetting agent, water, sweeting agent are mixed into aqueous phase, add American-cockroach-extract, potassium salt, tranamic acid, essence is mixed to without after muddy shape, becomes to stir limit and slowly add aqueous phase, and filter subpackage, prepared by collutory.
Clinical oral test is carried out to the collutory of embodiment 18 ~ 33, comparative example 13 ~ comparative example 24, chooses the people suffering from sensitivity of tooth, oral ulcer, often organize ten people.They use the collutory of embodiment 18 ~ 33, comparative example 13 ~ comparative example 24 respectively on the basis of daily habits (every day gargles three times), continue one week.
Result is as follows:
(1), the result on trial of embodiment 18 ~ embodiment 25, comparative example 13 ~ comparative example 24 is as shown in table 7:
Table 7
From table 7, can find out, the therapeutic effect of embodiment 18 ~ embodiment 25 is significantly better than the therapeutic effect of comparative example 13 ~ comparative example 17, and the best results of embodiment 19 ~ embodiment 23, American-cockroach-extract, potassium salt are described, the proportion relation of tranamic acid three determines its therapeutic effect.By embodiment 21 and comparative example 16, the result of comparative example 17 shows, although the American-cockroach-extract added separately in the comparative example 16 ~ comparative example 17 of adding in collutory, potassium salt, the content of tranamic acid is all consistent with embodiment 21, but result but differs greatly, this just illustrates American-cockroach-extract, potassium salt, the compositions of tranamic acid effectively can treat oral ulcer, the symptom of gingivitis and alleviation sensitivity of tooth, three only with the use of time, best results, this just illustrates American-cockroach-extract, potassium salt, tranamic acid compositions effectively can treat oral ulcer, gingival hemorrhage, alleviate the symptom of sensitivity of tooth.
(2), the result on trial of embodiment 26 ~ embodiment 33, comparative example 18 ~ comparative example 24 is as shown in table 8:
Table 8
From table 8, can find out, the therapeutic effect of embodiment 26 ~ embodiment 33 is significantly better than the therapeutic effect of comparative example 18 ~ comparative example 24, and the best results of embodiment 27 ~ embodiment 31, American-cockroach-extract, potassium salt are described, the proportion relation of tranamic acid three determines its therapeutic effect.Shown by the result of embodiment 29 with comparative example 22 ~ comparative example 24, although the American-cockroach-extract added separately in the comparative example 22 ~ comparative example 24 of adding in collutory, potassium salt, the content of tranamic acid is all consistent with embodiment 29, but result but differs greatly, this just illustrates American-cockroach-extract, potassium salt, the compositions of tranamic acid effectively can treat oral ulcer, the symptom of gingivitis and alleviation sensitivity of tooth, three only with the use of time, best results, this just illustrates American-cockroach-extract, potassium salt, tranamic acid compositions effectively can treat oral ulcer, gingival hemorrhage, alleviate the symptom of sensitivity of tooth.
Can draw from table 7, table 8, collutory containing American-cockroach-extract, potassium salt obviously can treat oral ulcer, alleviate teeth sensitive symptoms, and the collutory containing American-cockroach-extract, potassium salt, tranamic acid obviously can treat oral ulcer, gingivitis, alleviation teeth sensitive symptoms, and its effect is all effective than un-added collutory.
For a person skilled in the art, under the prerequisite not departing from technical solution of the present invention, can also make some distortion and improvement, these also should be considered as protection scope of the present invention, and these all can not affect effect of the invention process and practical applicability.
Claims (10)
1. containing the oral care composition of periplaneta americana, it is characterized in that: its raw material is primarily of American-cockroach-extract, potassium salt composition, and its raw materials quality number is: American-cockroach-extract 0.1 ~ 20 part; Potassium salt 0.1 ~ 5 part.
2., as claimed in claim 1 containing the oral care composition of periplaneta americana, it is characterized in that: described raw material also has tranamic acid, the mass fraction of each raw material is: American-cockroach-extract 0.1 ~ 20 part; Potassium salt 0.1 ~ 5 part; Tranamic acid 0.01 ~ 0.1 part.
3., as claimed in claim 1 containing the oral care composition of periplaneta americana, it is characterized in that: the mass fraction of described raw material is: American-cockroach-extract 0.5 ~ 10 part; Potassium salt 0.3 ~ 5 part.
4., as claimed in claim 2 containing the oral care composition of periplaneta americana, it is characterized in that: the mass fraction of described raw material is: American-cockroach-extract 0.5 ~ 10 part; Potassium salt 0.3 ~ 5 part; Tranamic acid 0.015 part.
5. as in claim 1 ~ 4 as described in any one containing the oral care composition of periplaneta americana, it is characterized in that: described American-cockroach-extract comprises one or more mixture in the water extract of periplaneta americana different parts or alcohol extract, periplaneta americana fine powder.
6., as contained the oral-cavity article of the oral care composition of periplaneta americana in claim 1 ~ 4 as described in any one, it is characterized in that: comprise toothpaste, collutory, dentifrice, tooth paste or ointment preparation, tooth gel and chewing gum.
7. oral-cavity article as claimed in claim 6, is characterized in that: the raw materials quality number of the oral care composition in described toothpaste is: American-cockroach-extract 6 parts; Potassium salt 5 parts; Tranamic acid 0.015 part.
8. oral-cavity article as claimed in claim 6, is characterized in that: the raw materials quality number of the oral care composition in described collutory is: American-cockroach-extract 5 parts; Potassium salt 1 part; Tranamic acid 0.015 part.
9. the oral-cavity article as described in claim 7, is characterized in that: in the raw material composition of described toothpaste, also comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water.
10. the preparation method of toothpaste in oral-cavity article as claimed in claim 9, it is characterized in that: first add wetting agent, add binding agent rapid stirring homogenizing again, then sweeting agent, American-cockroach-extract, potassium salt, tranamic acid is added successively, add surfactant, antiseptic again, and uniform stirring; Then evacuation adds abrasivus, stirs homogenizing, finally adds essence, and stir homogenizing, degassed, preparation completes.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510641A (en) * | 2017-07-22 | 2017-12-26 | 深圳诺漫斯生物科技有限公司 | A kind of early dress toothpaste of American-cockroach-extract-containing and preparation method thereof |
| CN108066397A (en) * | 2016-11-16 | 2018-05-25 | 上海星恺医药科技有限公司 | Pharmaceutical composition |
| CN108403723A (en) * | 2018-05-07 | 2018-08-17 | 中国科学院昆明动物研究所 | A kind of American-cockroach-extract that intervening AD and its extracting method and application |
| CN113456567A (en) * | 2021-04-30 | 2021-10-01 | 唐山青木生物科技有限公司 | Periplaneta americana mouthwash and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101563064A (en) * | 2006-11-14 | 2009-10-21 | 新时代株式会社 | Oral composition containing crystalline cellulose surface-treated with water-soluble substance |
| US20100152304A1 (en) * | 2008-12-17 | 2010-06-17 | Geng Funeng | Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations |
| CN101837019A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN102302518A (en) * | 2011-08-12 | 2012-01-04 | 云南省腾冲制药厂 | Cockroach extractive and prepared oral care composition as well as preparation method and applications |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
| CN104688648A (en) * | 2013-12-05 | 2015-06-10 | 耿福能 | Oral composition and preparation method thereof |
-
2015
- 2015-07-01 CN CN201510377497.3A patent/CN104983744A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101563064A (en) * | 2006-11-14 | 2009-10-21 | 新时代株式会社 | Oral composition containing crystalline cellulose surface-treated with water-soluble substance |
| US20100152304A1 (en) * | 2008-12-17 | 2010-06-17 | Geng Funeng | Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations |
| CN101837019A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN102302518A (en) * | 2011-08-12 | 2012-01-04 | 云南省腾冲制药厂 | Cockroach extractive and prepared oral care composition as well as preparation method and applications |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN104688648A (en) * | 2013-12-05 | 2015-06-10 | 耿福能 | Oral composition and preparation method thereof |
| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066397A (en) * | 2016-11-16 | 2018-05-25 | 上海星恺医药科技有限公司 | Pharmaceutical composition |
| CN107510641A (en) * | 2017-07-22 | 2017-12-26 | 深圳诺漫斯生物科技有限公司 | A kind of early dress toothpaste of American-cockroach-extract-containing and preparation method thereof |
| CN108403723A (en) * | 2018-05-07 | 2018-08-17 | 中国科学院昆明动物研究所 | A kind of American-cockroach-extract that intervening AD and its extracting method and application |
| CN113456567A (en) * | 2021-04-30 | 2021-10-01 | 唐山青木生物科技有限公司 | Periplaneta americana mouthwash and preparation method thereof |
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