CN113318057B

CN113318057B - Old people nursing toothpaste and preparation method and application thereof

Info

Publication number: CN113318057B
Application number: CN202110635628.9A
Authority: CN
Inventors: 邓媛; 吴超
Original assignee: Yueyang Vocational Technical College
Current assignee: Yueyang Vocational Technical College
Priority date: 2021-06-08
Filing date: 2021-06-08
Publication date: 2022-04-22
Anticipated expiration: 2041-06-08
Also published as: CN113318057A

Abstract

The invention discloses nursing toothpaste for old people and a preparation method and application thereof. The toothpaste for nursing the old comprises a traditional Chinese medicine extract and a toothpaste matrix, wherein the traditional Chinese medicine extract comprises a honeysuckle extract, an eucommia ulmoides leaf extract, a cogongrass rhizome extract, a plantain herb extract and a gallnut extract. The toothpaste provided by the scheme of the invention is designed aiming at the oral problems of the old, has the effects of resisting inflammation, easing pain, resisting bacteria and pathogenic microorganisms, stopping bleeding, desensitizing, reducing pathogenic fire and the like, and the main effective components of the toothpaste are extracts of pure natural Chinese herbal medicines and do not contain antibiotics and hormone chemical medicines.

Description

Old people nursing toothpaste and preparation method and application thereof

Technical Field

The invention belongs to the technical field of daily chemicals, and particularly relates to nursing toothpaste for the aged, and a preparation method and application thereof.

Background

Along with the development and progress of the society, the cognition of people on oral care is gradually deepened, the requirement on toothpaste is not limited to tooth cleaning, people more require cleaning and care combination, the improvement of substance life follows, the oral health of people faces the unprecedented challenge, and the accidents of oral diseases caused by the change of living habits, oral environments and the like occur. In general, popular toothpaste products in the market not only have basic cleaning and sanitation functions, but also are often formed into functional toothpaste by adding functional ingredients, so that the functions of oral health care, adjuvant therapy and the like are increased, and the functions of the toothpaste are gradually developed from pure tooth cleaning to the direction of preventing and treating dental diseases, therefore, people have more and more great demand on the toothpaste with nursing efficacy, and particularly, the functional toothpaste becomes a market and research hotspot for special nursing toothpastes for different people.

The old people are a special group, and the teeth of the old people are easy to generate phenomena of acid numbness, pain and the like when being subjected to external stimulation, such as cold, hot, sour and sweet stimulation and the like. Meanwhile, many old people have weak drug absorption capacity due to reduced recovery capability, so that the old patients often suffer long-term treatment and repeated treatment in clinic, and the pain of the old people is aggravated. Therefore, by using a special care toothpaste, it is a simple and efficient way to care for the oral cavity of the elderly by brushing their teeth. However, since market purchasing power is mainly concentrated on the young population, there are few studies and reports on toothpaste for oral care for the elderly. Compared with the oral cavity of a young person, the oral cavity of an old person is more prone to the problems of ache, peculiar smell, bleeding, excessive internal heat, long-lasting foam and the like, and the effect of nursing the toothpaste of the old person can be greatly reduced by completely applying the existing toothpaste formula or completely adopting the toothpaste formula of the young group.

With the development of science and technology, raw materials capable of being used as toothpaste efficacy additives are continuously developed. When a plurality of research institutions and enterprises develop new toothpaste products, functional substances are added to enable the toothpaste to have specific functions, such as the fluorine-containing toothpaste added with fluoride, the toothpaste can play a role in effectively preventing decayed teeth and enhancing the capacity of resisting the decayed teeth; by adding substances such as strontium ions, potassium ions, urea, vitamin E nicotinate, nano hydroxyapatite and the like, the effects of sealing dentinal tubules, calming and anesthetizing dental pulp nerves, strengthening gums, repairing enamel and the like by the toothpaste can be realized, and the anti-allergy effect is achieved. The use of Chinese herbal medicines has long history in China, and partial enterprises or scientific research institutions extract the effective components of the Chinese herbal medicines through modern technology and add the effective components into toothpaste. The specific Chinese herbal medicines contain various alkaloids, tannins or volatile oil, and have the effects of diminishing inflammation and inhibiting bacteria, relieving pain, reducing local anesthesia, reducing internal heat, cleaning, astringing and the like. Has certain auxiliary curative effect on periodontitis, gingivitis, gingival bleeding and the like caused by certain reasons, and has certain effect on oral care of the old. Traditional Chinese medicine enterprises such as Yunnan Baiyao, Pianzaihuang and the like occupy a large market share in the high-end toothpaste market through the research and development and popularization of Chinese herbal medicine toothpaste. In a word, the effects of the toothpaste in various aspects such as bacteriostasis, caries prevention, inflammation resistance, desensitization, hemostasis, whitening, breath freshening and the like can be realized by adding the Chinese herbal medicine components. The existing research shows that the toothpaste product formed by adding the Chinese herbal medicine extract has certain effect on preventing and treating the oral problems of the old, however, the toothpaste in the related technology generally has only one effect and cannot comprehensively care the relatively complicated oral problems of the old.

In conclusion, the development of the toothpaste for nursing the old is very necessary, and the toothpaste for nursing the old has a wide market prospect with the daily increase of the population of the old in China, and the current market is fresh with the products.

Statements in this background are not admitted to be prior art to the present disclosure.

Disclosure of Invention

The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides the toothpaste for nursing the old, which has a good nursing effect on the oral cavity of the old.

The invention also provides a preparation method of the toothpaste for nursing the old people.

The invention also provides an application of the toothpaste for nursing the old people.

According to one aspect of the invention, the toothpaste for nursing the aged is provided, and comprises traditional Chinese medicine extracts and a toothpaste matrix, wherein the traditional Chinese medicine extracts comprise honeysuckle extracts, eucommia ulmoides leaf extracts, lalang grass rhizome extracts, plantain herb extracts and gallnut extracts.

According to a preferred embodiment of the present invention, at least the following advantages are provided: the toothpaste provided by the scheme of the invention is designed aiming at the oral problems of the old, and has the effects of resisting inflammation, easing pain, resisting bacteria and pathogenic microorganisms, stopping bleeding, desensitizing, reducing pathogenic fire and the like, the main functional components of the product are extracts of pure natural Chinese herbal medicines, and the product does not contain antibiotics and hormone chemical medicines, and the eucommia ulmoides leaves have an antibacterial effect on the oral pathogenic bacteria and also have the effects of resisting inflammation and easing pain; the rhizoma Imperatae has effects of shortening blood coagulation time and bleeding time, relieving inflammation and pain, and desensitizing; the plantain herb has the effects of reducing pathogenic fire, treating ulcer, resisting inflammation and the like; the Chinese gall has the effects of astringing, stopping bleeding, inhibiting bacteria and the like, the honeysuckle has the effects of clearing heat, reducing internal heat, diminishing inflammation, relieving pain, removing halitosis and the like, the added Chinese herbal medicine extract has the effects of diminishing inflammation, relieving pain, resisting bacteria and pathogenic microorganisms, stopping bleeding, desensitizing, reducing internal heat and the like in a composite synergistic mode, has no toxic or side effect, is particularly suitable for oral care of the old, and has a good market prospect.

In some embodiments of the invention, the mass ratio of the honeysuckle extract to the eucommia ulmoides leaf extract to the cogongrass rhizome extract to the plantain herb extract to the gallnut extract is 4-6: 2-5: 3-5: 2-4.

In some preferred embodiments of the present invention, the mass ratio of the honeysuckle extract, the eucommia ulmoides leaf extract, the cogongrass rhizome extract, the plantain herb extract and the gallnut extract is about 5:2.8:3:3.5: 3.

In some embodiments of the invention, the toothpaste base comprises an abrasive; preferably, the abrasive agent comprises at least one of silica or calcium carbonate; more preferably, the particle size of the silica is 0.5 to 30 μm.

In some embodiments of the invention, the toothpaste base comprises a humectant; preferably, the humectant comprises at least one of glycerin or propylene glycol.

In some preferred embodiments of the present invention, the toothpaste base comprises a surfactant; preferably, the surfactant is selected from at least one of sodium lauroyl sarcosinate, sodium lauryl sulfate or sodium laureth sulfate.

In some embodiments of the invention, the toothpaste base comprises a preservative; preferably, the preservative comprises at least one of paraben or sodium benzoate.

In some embodiments of the invention, the toothpaste base comprises a thickening agent; preferably, the thickener comprises at least one of xanthan gum or xanthan gum.

In some preferred embodiments of the present invention, the toothpaste for geriatric care comprises the following raw materials in parts by weight: 20-25 parts of silicon dioxide, 25-35 parts of glycerol, 2-4 parts of sodium laureth sulfate, 1-2 parts of xanthan gum, 0.5-1.5 parts of essence, 2-7 parts of flavoring agent, 0.1-0.3 part of nipagin ester, 4-6 parts of honeysuckle extract, 2-5 parts of eucommia ulmoides leaf extract, 3-5 parts of cogongrass rhizome extract, 3-5 parts of plantain herb extract, 2-4 parts of Chinese gall extract and 10-25 parts of deionized water. The added components all conform to the GB22115-2008 specification of raw materials for toothpaste, and the toothpaste has good industrial application prospect.

In some embodiments of the invention, the flavoring agent is at least one of sodium saccharin, stevioside, D-sorbitol, xylitol, menthol.

In some embodiments of the invention, the fragrance is at least one of peppermint, spearmint, cinnamon, or oil of wintergreen.

According to another aspect of the present invention, there is provided a method for preparing a toothpaste for geriatric care, comprising the steps of:

s1, taking powdery honeysuckle extract, eucommia ulmoides leaf extract, cogongrass rhizome extract, plantain herb extract and gallnut extract, and mixing the powdery honeysuckle extract, the eucommia ulmoides leaf extract, the cogongrass rhizome extract, the plantain herb extract and the gallnut extract with an abrasive to obtain traditional Chinese medicine extract mixture powder;

mixing humectant, surfactant and thickener, adding water, stirring to obtain a semi-transparent viscous liquid, and standing to obtain toothpaste matrix mixture;

s2, mixing the traditional Chinese medicine extract powder with the toothpaste matrix mixture to obtain the aged people care toothpaste.

According to some embodiments of the invention, the preparation method further comprises the steps of preparing a powdered honeysuckle extract, an eucommia ulmoides leaf extract, a cogongrass rhizome extract, a plantain herb extract and a gallnut extract, and specifically comprises the steps of extracting the powdered honeysuckle extract, the eucommia ulmoides leaf extract, the cogongrass rhizome extract, the plantain herb extract and the gallnut extract to obtain a liquid honeysuckle extract, the eucommia ulmoides leaf extract, the cogongrass rhizome extract, the plantain herb extract and the gallnut extract with relative mass density of 1.02-1.08 at 55-65 ℃, and freeze-drying the liquid honeysuckle extract, the eucommia ulmoides leaf extract, the cogongrass rhizome extract, the plantain herb extract and the gallnut extract.

According to some embodiments of the present invention, the stirring speed in the step S1 is 650-800 rpm; preferably 750 rpm.

According to some embodiments of the invention, the stirring time in step S1 is 18-25 min; preferably 20 min.

According to some embodiments of the invention, the temperature of the mixture during the stirring in the step S1 is maintained at 65-80 ℃; preferably 70 deg.c.

According to some embodiments of the invention, the standing time in the step S1 is 8-15 h; preferably 10 hours.

According to some embodiments of the invention, the step S1 further includes adding a flavoring agent when adding the frictionizer.

According to some embodiments of the present invention, the step S1 further comprises adding essence and preservative to the mixture after standing under stirring again.

According to some embodiments of the invention, the rotation speed of the re-stirring is 650 to 800 rpm; preferably, the time is 5-10 min; more preferably 65 to 80 ℃.

According to some preferred embodiments of the invention, the rotation speed of the re-stirring is 750 rpm; preferably, the time is 6 min; more preferably 70 deg.c.

According to some embodiments of the present invention, the vacuum degree of the mixing process in the step S2 is maintained between-0.09 MPa and-0.098 MPa (preferably-0.095 MPa), and the time is 8-10 min (preferably 9 min).

The preparation method according to a preferred embodiment of the present invention has at least the following advantageous effects: the preparation method provided by the invention has the advantages of simple preparation process, simplicity and convenience in operation and good industrial application prospect.

According to a further aspect of the invention, the application of the toothpaste for nursing the aged in the preparation of the oral care products for the aged is provided.

According to some embodiments of the invention, the senior oral care product further comprises at least one of a toothbrush, a mouthwash, a dentifrice, a tooth gel, or a chewing gum.

The application according to a preferred embodiment of the invention has at least the following advantageous effects: the toothpaste of the invention can be combined with other oral care products into an oral care product, so that the oral care product is more convenient to carry and use, and can comprehensively and effectively care the oral cavity.

Detailed Description

The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention. The test methods used in the examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are commercially available reagents and materials unless otherwise specified.

Example 1

The toothpaste for nursing the old people comprises the following raw materials in percentage by weight:

20% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 5% of honeysuckle extract, 2.8% of eucommia ulmoides leaf extract, 3% of cogongrass rhizome extract, 3.5% of plantain herb extract, 3% of nutgall extract and the balance of deionized water.

A preparation method of a toothpaste for nursing old people comprises the following steps:

(1) taking folium cortex eucommiae, rhizoma imperatae, plantain, Chinese gall and honeysuckle, extracting (respectively extracting by the following method, namely taking traditional Chinese medicinal materials, fully mixing, crushing into coarse powder, putting the coarse powder into an ultrasonic extractor, adding 60% (v/v) ethanol with 6 times of volume, carrying out ultrasonic extraction once, filtering an extracting solution, adding 15% (v/v) ethanol into filter residues, carrying out ultrasonic extraction for 1 time, filtering the extracting solution, combining 2 times of filtrate, recovering ethanol, concentrating to a liquid medicine with the relative mass density of 1.02-1.08 at 60 ℃ to respectively obtain a honeysuckle extract, an folium cortex eucommiae extract, a rhizoma imperatae extract, a plantain extract and a Chinese gall extract, respectively carrying out freeze drying on the liquid medicine to obtain extract powder, and respectively carrying out freeze drying on the powder obtained according to the formula, silicon dioxide and a flavoring agent weighed according to the formula to obtain powder A;

(2) weighing glycerol, sodium laureth sulfate and xanthan gum according to a formula, uniformly mixing, adding deionized water, stirring, setting the temperature of a stirrer at 70 ℃, the rotating speed at 750r/min, stirring for 20 minutes until the mixture is in a uniform, semitransparent and sticky liquid state, and standing for 10 hours to obtain a mixture A;

(3) adding essence and nipagin ester into the mixture A obtained in the step (2) according to a formula, setting the temperature of a stirrer at 70 ℃, the rotating speed at 750r/min and the stirring time at 6 minutes, and stirring until the mixture is uniformly mixed to obtain a mixture B;

(4) adding the mixture B and the powder A into a vacuum paste making machine, starting a vacuum pump of the paste making machine to vacuumize while stirring, keeping the vacuum degree at-0.095 MPa, and closing the vacuum pump and the vacuum paste making machine after 9 minutes to obtain paste;

(5) pouring out paste, filling into a toothpaste hose, and sealing the tail by a tail sealing machine.

(6) The real-time indexes of the toothpaste are detected according to the national standard GB/T8372-2017 toothpaste, and the result meets the standard requirement.

Example 2

25% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 4% of honeysuckle extract, 3% of eucommia ulmoides leaf extract, 3% of cogongrass rhizome extract, 4% of plantain herb extract, 2.5% of nutgall extract and the balance of deionized water.

(2) weighing glycerol, sodium laureth sulfate and xanthan gum according to a formula, uniformly mixing, adding deionized water, stirring, setting the temperature of a stirrer at 70 ℃, the rotating speed at 800r/min and the stirring time at 25 minutes until the mixture is in a uniform, semitransparent and viscous liquid state, and standing for 12 hours to obtain a mixture A;

(3) adding essence and nipagin ester into the mixture A in the step (2) according to a formula, setting the temperature of a stirrer to be 70 ℃, the rotating speed to be 800r/min and the stirring time to be 7 minutes, and stirring until the mixture is uniformly mixed to obtain a mixture B;

Example 3

25% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 6% of honeysuckle extract, 5% of eucommia ulmoides leaf extract, 5% of cogongrass rhizome extract, 5% of plantain herb extract, 4% of nutgall extract and the balance of deionized water.

Example 4

20% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 5% of honeysuckle extract, 5% of eucommia ulmoides leaf extract, 5% of cogongrass rhizome extract, 5% of plantain herb extract, 5% of nutgall extract and the balance of deionized water.

Example 5

20% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 3% of honeysuckle extract, 3% of eucommia ulmoides leaf extract, 3% of cogongrass rhizome extract, 3% of plantain herb extract, 3% of nutgall extract and the balance of deionized water.

Comparative example 1

20% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 5% of honeysuckle extract, 2.8% of eucommia ulmoides leaf extract, 3% of cogongrass rhizome extract, 3.5% of plantain herb extract and the balance of deionized water.

(1) taking folium cortex eucommiae, rhizoma imperatae, plantain and honeysuckle, extracting (respectively extracting by the following method: taking Chinese medicinal materials, fully mixing, crushing into coarse powder, placing in an ultrasonic extractor, adding 60% (v/v) ethanol with 6 times volume amount, carrying out ultrasonic extraction once, filtering an extracting solution, adding 15% (v/v) ethanol into filter residue, carrying out ultrasonic extraction for 1 time, filtering the extracting solution, combining 2 times of filtrate, recovering ethanol, concentrating to a liquid medicine with a relative mass density of 1.02-1.08 at 60 ℃) to respectively obtain a honeysuckle extract, an folium cortex eucommiae extract, a rhizoma imperatae extract and a plantain extract, respectively carrying out freeze drying on the liquid medicine to obtain extract powder, and respectively carrying out freeze drying on the powder obtained according to the formula and silicon dioxide and a flavoring agent weighed according to the formula to obtain powder A;

Comparative example 2

20% of silicon dioxide, 30% of glycerol, 3% of sodium laureth sulfate, 1.5% of xanthan gum, 1% of peppermint, 0.5% of spearmint, 2% of D-sorbitol, 4% of xylitol, 0.2% of nipagin ester, 5% of honeysuckle extract, 3% of cogongrass rhizome extract, 3.5% of plantain herb extract, 3% of Chinese gall extract and the balance of deionized water.

(1) taking plantain herb, cogongrass rhizome, Chinese gall and honeysuckle, extracting (respectively extracting by the following method, namely taking Chinese medicinal materials, fully mixing, crushing into coarse powder, putting the coarse powder into an ultrasonic extractor, adding 60% (v/v) ethanol with 6 times of volume, carrying out ultrasonic extraction once, filtering an extracting solution, adding 15% (v/v) ethanol into filter residues, carrying out ultrasonic extraction for 1 time, filtering the extracting solution, combining 2 times of filtrate, recovering ethanol, concentrating to a liquid medicine with the relative mass density of 1.02-1.08 at 60 ℃ to respectively obtain a honeysuckle extract, a plantain herb extract, a cogongrass rhizome extract and a Chinese gall extract, respectively carrying out freeze drying on the liquid medicine to obtain extract powder, and respectively carrying out freeze drying on the powder obtained according to the formula and silicon dioxide and a flavoring agent weighed according to the formula to obtain powder A;

Test example

1. Physical, chemical and sensory evaluation

The toothpaste prepared in each example and comparative example was subjected to physicochemical and sensory evaluations, and the evaluation results are shown in table 1.

TABLE 1 physicochemical and sensory evaluation

Product(s)	Appearance of the product	Phenomenon of wire drawing	Particles of excessive hardness	pH
					Example 1	Light yellow, fine and moderate consistency	Is obvious	Without particles of excessive hardness	7.07
Example 2	Light yellow, fine and thick	Is obvious	Without particles of excessive hardness	7.01
					Example 3	Light yellow, fine and thick	Is obvious	Without particles of excessive hardness	7.10
Example 4	Light yellow, fine and moderate consistency	Is obvious	Without particles of excessive hardness	7.05
					Example 5	Light yellow, fine and moderate consistency	Is obvious	Without particles of excessive hardness	7.03
Comparative example 1	Light yellow, fine and moderate consistency	Is obvious	Without particles of excessive hardness	7.04
					Comparative example 2	Light yellow, fine and moderate consistency	Is obvious	Without particles of excessive hardness	7.02

As can be seen from Table 1, the toothpastes prepared according to the examples and comparative examples of the present invention have good overall appearance and stringiness, no excessively hard particles, and satisfactory pH.

2. Anti-inflammatory assay

The toothpastes prepared in the examples and comparative examples were subjected to an experiment for the influence of swelling of auricles of mice caused by p-xylene to investigate the anti-inflammatory effect.

Deionized water and a toothpaste base without Chinese herbal medicines (the content of the toothpaste base is the same as that in example 1) are respectively used as a negative control group 1 and a negative control group 2, dexamethasone acetate ointment is used as a positive control group, the toothpastes obtained in examples 1-5 are used as test groups 1-5, and the toothpastes obtained in comparative examples 1-2 are used as comparative groups 1-2. 100 female white mice qualified for quarantine are randomly divided into ten groups and 10 mice per group according to body weight. Respectively a negative control group 1, a negative control group 2, a positive control group, a test group 1, a test group 2, a test group 3, a test group 4, a test group 5, a comparison group 1 and a comparison group 2.

Xylene was evenly applied to the inner and outer surfaces of the auricle of the right ear of each mouse to cause inflammation at a dose of 100. mu.L/mouse (50. mu.L/mouse per single surface), and the left ear was left untreated as a blank control. After 10 minutes of xylene-induced inflammation, the mice were individually coated with deionized water (0.1 mL/mouse), a herbal-free toothpaste base (0.1 g/mouse), dexamethasone acetate ointment (0.1 g/mouse), the corresponding numbered example or comparative toothpaste (0.1 g/mouse), according to the group. After 20 minutes of xylene-induced inflammation, the mice were coated with deionized water (0.1 mL/mouse), a herbal-free toothpaste base (0.1 g/mouse), dexamethasone acetate ointment (0.1 g/mouse), the correspondingly numbered toothpaste of the examples or comparative example (0.1 g/mouse), respectively, in groups.

After applying the toothpaste for 30 minutes for the second time, the cervical vertebrae of the tested mouse are dislocated and killed, auricles on two sides are cut off, the tested object on the auricles on the right side is cleaned by normal saline, and residual normal saline is sucked by a cotton ball. The auricles of both ears were overlapped and the left and right auricles were punched out at once with a sharp punch. The ear pieces were weighed separately and the swelling value was calculated, the smaller the swelling value, the better the anti-inflammatory effect. The test results are shown in Table 2.

Table 2 swelling value measuring table

The test results show that the anti-inflammatory effect of the toothpaste adopting the embodiment of the invention is equivalent to the level of a positive control group, wherein the effect of the honeysuckle extract, the eucommia ulmoides leaf extract, the lalang grass rhizome extract, the plantain herb extract and the gallnut extract in the mass ratio of 4-6: 2-5: 3-5: 2-4 is better than that of the positive control group, the effect of the toothpaste with the ratio out of the range is slightly weaker than that of the positive control group, the effect of the toothpaste containing only part of the Chinese herbal medicine extract is obviously weaker than that of the toothpaste of the test group and the positive control group, and the traditional Chinese medicine extracts in the scheme of the invention have a synergistic effect.

3. Analgesic test

Selecting female mice with the weight of 18 g-22 g by adopting a hot plate test, and selecting 100 female mice with the pain threshold of 5 s-30 s for carrying out the hot plate test by using the time for licking hind feet or jumping reaction of the mice as an index of the pain threshold. 100 mice were randomly divided into 10 groups of 10 mice each. Deionized water and toothpaste matrix without Chinese herbal medicines are respectively used as a negative control group 1 and a negative control group 2, aspirin is used as a positive control group, the toothpaste obtained in examples 1-5 is used as test groups 1-5, and the toothpaste obtained in comparative examples 1-2 is used as comparative groups 1-2. 100 female white mice qualified for quarantine are randomly divided into ten groups and 10 mice per group according to body weight. Respectively a negative control group 1, a negative control group 2, a positive control group, a test group 1, a test group 2, a test group 3, a test group 4, a test group 5, a comparison group 1 and a comparison group 2.

The mice used in different experimental groups are numbered and respectively placed on hot plates at 55 ℃ for 60 seconds, the time for the mice to lick the hind paw or jump is observed, the pain threshold value is observed twice, the time interval between the two observations is ten minutes, and the average value is taken as the pain threshold value before administration. Then, the four limbs of each mouse were smeared with 0.1g of the drug per foot, administered 2 times with 30-minute intervals each time, 30 minutes after the second administration, respectively placed on hot plates at 55 ℃ for 60 seconds, the time of the mouse licking the hind paw or the skip reaction was observed, the pain threshold was observed twice, the interval between the two observations was ten minutes, and the average value was taken as the pain threshold after administration. A higher pain threshold indicates a better analgesic effect. The results are shown in Table 3.

TABLE 3 Effect of toothpaste on analgesic Effect in mice

As can be seen from the above table, the toothpaste according to the embodiment of the present invention has a good analgesic effect, and the comparative group also has a certain analgesic effect compared to the common toothpaste without Chinese herbal medicines on the market, but is much weaker than the toothpaste according to the embodiment, thereby indicating that the toothpaste has a good analgesic effect.

4. Detection of odor removal and breath freshening performance

270 old patients with bad breath were selected, the oral hygiene environment was equivalent, the ages were 55-75 years old, and the groups were randomly divided into 9 groups, and the toothpaste obtained in examples 1-5, the toothpaste obtained in comparative examples 1-2, the comparative example 3 (commercially available common toothpaste), and the comparative example 4 (toothpaste not containing the Chinese herbal medicine of the present invention) were used 2 times a day (once in the morning and evening), the usage period was one month, and the bad breath removal condition was counted after one month, and the results are shown in table 4.

TABLE 4

The experimental result shows that the toothpaste obtained in the embodiment of the invention has a good odor removing effect, and the comparative example group has a certain odor removing effect, but the performance is obviously weaker than that of the embodiment group, so that the traditional Chinese medicine extract composition provided by the scheme of the invention also has a synergistic effect in the aspect of removing oral odor.

In conclusion, according to the mechanism of nursing the oral cavity of the old people by the Chinese herbal medicines, the invention skillfully adopts the effective Chinese herbal medicine extract composition by combining the characteristics of the Chinese herbal medicines and aiming at the oral cavity characteristics of the old people, and the special composition of the scheme of the invention is added into the toothpaste, so that the formula of the toothpaste for nursing the old people with better effect and the preparation method thereof are formed. The selected Chinese herbal medicines and the substances of the toothpaste both accord with the GB22115-2008 specification of raw materials for toothpaste, and the selected Chinese herbal medicines are common, safe and nontoxic Chinese herbal medicines with moderate price, are not forbidden, are limited to use, are controversial and the like. The invention preferably selects five common traditional Chinese medicines, namely eucommia ulmoides leaves, lalang grass rhizome, plantain, gallnut and honeysuckle, which are respectively added into the toothpaste in the form of extracts.

Eucommia leaves are widely planted in China, and contain rich nutrient substances including VB1, VE, beta-carotene and other vitamins, 17 free amino acids, selenium and other 15 trace elements. The active components of folium Eucommiae include flavonoids, iridoids, phenylpropanoids, lignanoids, polysaccharides, and gutta Percha. The main pharmacological actions are blood pressure reduction, blood fat reduction, blood sugar reduction, inflammation resistance, virus resistance, fatigue resistance, muscle and bone strengthening, aging resistance and the like.

Cogongrass rhizome, which is distributed in most areas of China. Is cold in nature, sweet in taste, slow in nature, and capable of entering blood, and has the functions of clearing heat, promoting urination, cooling blood, stopping bleeding, etc., the medicinal part is dry rhizome, and the main chemical components are triterpenes, lactone, organic acid, etc. Studies show that the cogongrass rhizome can shorten the blood coagulation time and the bleeding time, and also has the effects of resisting inflammation and easing pain.

Plantain herb is distributed in most areas of China. Plantain herb is sweet in flavor and cold in nature. Can be used for treating urinary obstruction, stranguria with turbid urine, conjunctival congestion, swelling and pain, pharyngitis, cough, and skin ulcer. It is also shown by research that plantain herb also has the function of scavenging oxygen free radicals and has certain effect on inflammation.

Galla chinensis is produced in Sichuan, Guizhou, Yunnan, Shaanxi, Guangxi, etc. areas of China. The main ingredient is Galla chinensis tannin, and in addition contains gallic acid, fat, resin and wax. The Galla chinensis has astringent, antidiarrheal, hemostatic, and antibacterial effects, and can be used for treating thrush, stomatitis, and odontitis.

Honeysuckle is a plant of Caprifoliaceae, widely distributed in south and north of China, is a common Chinese herbal medicine for clearing heat and reducing internal heat, has the main functions of clearing heat and removing toxicity and dispelling wind and heat, and is mainly used for treating deficient fire rising, carbuncle and furuncle, epidemic febrile disease and fever, heat toxin and bloody dysentery, wind-heat type common cold and the like. And has the functions of clearing away heat, removing internal heat, diminishing inflammation, relieving pain and eliminating halitosis.

The toothpaste formula is based on the pharmacological effects of the five Chinese herbal medicines, and is subjected to repeated experiments (including experiments on stability, decontamination capability, anti-inflammatory analgesic capability, antibacterial and pathogenic microorganism capability, hemostasis desensitization capability, fire reduction capability, sensory evaluation and the like) and small-range use tests, the addition amount and addition proportion of the Chinese herbal medicine extract are repeatedly researched, and the formula of adding the honeysuckle extract, the eucommia ulmoides leaf extract, the lalang grass rhizome extract, the plantain herb extract and the gallnut extract is finally determined, so that the toothpaste formula has a good nursing effect on the oral cavity of the old.

The additive is a pure natural Chinese herbal medicine compound extract, in order to keep the original color of the added Chinese herbal medicine, the Chinese herbal medicine is not decolored, and a certain amount of essence and flavoring agent can be added, so that the special smell of the Chinese herbal medicine can be covered, the toothpaste can show different tastes according to the needs, the taste of the toothpaste is greatly improved, and the effect of taking both the effect and the sense organ into consideration is realized.

In a word, the formula and the preparation method of the toothpaste for nursing the aged provided by the invention realize the composite action among the added substances by adding the specific Chinese herbal medicine extract substances with relatively fixed weight ratio, and can better meet the requirements of the toothpaste for nursing the aged. Related researches show that when the functional components are added into the functional toothpaste, the phenomena of limited action of single substances, poor synergistic effect of combined substances and the like are easy to occur, and comprehensive care of the oral cavity is difficult to realize.

The embodiments of the present invention have been described in detail, but the present invention is not limited to the embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

Claims

1. An old people nursing toothpaste is characterized in that: comprises traditional Chinese medicine extracts and toothpaste matrix, wherein the traditional Chinese medicine extracts comprise honeysuckle extract, eucommia bark leaf extract, cogongrass rhizome extract, plantain herb extract and gallnut extract; the mass ratio of the honeysuckle extract to the eucommia ulmoides leaf extract to the lalang grass rhizome extract to the plantain herb extract to the gallnut extract is 5:2.8:3:3.5: 3.

2. The toothpaste according to claim 1, wherein: the toothpaste base comprises an abrasive.

3. The toothpaste according to claim 2, wherein: the abrasive includes at least one of silica or calcium carbonate.

4. The toothpaste according to claim 3, wherein: the particle size of the silicon dioxide is 0.5-30 mu m.

5. The toothpaste according to claim 1, wherein: the toothpaste matrix comprises a humectant.

6. The toothpaste according to claim 5, wherein: the humectant includes at least one of glycerin or propylene glycol.

7. The toothpaste according to claim 1, wherein: the toothpaste base comprises a surfactant.

8. The toothpaste according to claim 7, wherein: the surfactant is selected from at least one of sodium lauroyl sarcosinate, sodium dodecyl sulfate or sodium laureth sulfate.

9. The toothpaste according to claim 1, wherein: the toothpaste for nursing the aged comprises the following raw materials in parts by weight: 20-25 parts of silicon dioxide, 25-35 parts of glycerol, 2-4 parts of sodium laureth sulfate, 1-2 parts of xanthan gum, 0.5-1.5 parts of essence, 2-7 parts of flavoring agent, 0.1-0.3 part of nipagin ester, 4-6 parts of honeysuckle extract, 2-5 parts of eucommia ulmoides leaf extract, 3-5 parts of cogongrass rhizome extract, 3-5 parts of plantain herb extract, 2-4 parts of Chinese gall extract and 10-25 parts of deionized water.

10. A method of preparing the toothpaste for geriatric care according to any one of claims 1 to 9, wherein: the method comprises the following steps:

11. The method of preparing a toothpaste for geriatric care according to claim 10, wherein: the stirring speed in the step S1 is 650-800 r/min.

12. The method of preparing a toothpaste for geriatric care according to claim 10, wherein: the stirring time in the step S1 is 18-25 min.

13. The method of preparing a toothpaste for geriatric care according to claim 10, wherein: the temperature of the mixture is maintained at 65-80 ℃ in the stirring process in the step S1.