CN113520957A - Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and preparation method thereof - Google Patents
Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and preparation method thereof Download PDFInfo
- Publication number
- CN113520957A CN113520957A CN202111017831.6A CN202111017831A CN113520957A CN 113520957 A CN113520957 A CN 113520957A CN 202111017831 A CN202111017831 A CN 202111017831A CN 113520957 A CN113520957 A CN 113520957A
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- parts
- extract
- gingivitis
- herbal medicine
- chinese herbal
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a Chinese herbal medicine toothpaste formula aiming at gingivitis and gingival atrophy, which comprises 3-15 parts of honeysuckle flower extract, 3-15 parts of fortune eupatorium herb extract, 3-15 parts of dipsacus asper extract, 2-15 parts of American agrimony extract and 2-15 parts of garden burnet extract; 1-5 parts of propylene glycol, 10-60 parts of sorbitol, 1-10 parts of glycerol, 5-25 parts of silicon dioxide, 0.01-1 part of sodium fluoride, 0.1-1 part of titanium dioxide, 0.1-1 part of saccharin sodium, 0.5-2 parts of xylitol, 0.5-2 parts of carboxymethyl cellulose, 0.1-0.8 part of xanthan gum, 0-5 parts of sodium dodecyl sulfate, 0-1 part of preservative and the balance of deionized water. The Chinese herbal medicine extract in the formula adopts the Chinese herbal medicine extract regularly sold in the existing market as a raw material, and teeth stains are removed by mild friction; the trace food-grade sodium fluoride can clean and simultaneously strengthen teeth, and effectively reduce the occurrence of dental caries.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and a preparation method thereof.
Background
Most adults suffer from periodontal disease, most of which is usually caused by improper tooth brushing, bacterial growth caused by food residues and local inflammation, and chronic inflammation progresses slowly. Gingivitis is usually the most common origin, and the bleeding caused by brushing teeth is not noticeable because of no subjective symptoms. Gingivitis is periodontitis when it develops to a certain degree, and the gingivitis can cause oral odor, gingival atrophy, tooth looseness, larger and more sparse tooth gaps and tooth falling of severe patients. Western medicine treatment is generally used to control inflammatory exacerbations, with essentially no specific treatment for gingival atrophy, often considered irreversible.
According to the traditional Chinese medicine, the kidney governs bones, produces marrow, and the teeth are the rest of bones. The teeth are closely related to the gums and the kidneys, stomach and large intestine, so that observation of the teeth and gums allows an initial assessment of renal and gastrointestinal lesions. Kidney qi deficiency can cause teeth to be sparse or roots to be exposed. The gum is associated with the stomach and intestine, and the flaming up of the stomach fire may cause simple symptoms of gum redness and swelling, halitosis, etc. If chronic gingivitis is not cured for a long time, the chronic gingivitis can cause gingival atrophy, tooth loosening, even falling off and the like.
At present, toothpaste aiming at oral inflammation mainly comprises simple cleaning and fluorine-containing mothproof components in the market, can temporarily clean teeth and oral cavities and solve the problem of dental caries, but has limited effect on oral inflammation such as periodontitis, gingival bleeding, oral ulcer and the like. Or even some toothpastes are used for gingival bleeding by adding tranexamic acid which is a western medicine hemostatic ingredient.
Aiming at the problems, the inventor develops a high-efficiency mild Chinese herbal medicine toothpaste by compounding traditional Chinese medicines, and can effectively solve the problem of chronic gingivitis and gingival atrophy by using the toothpaste. Can be used for preventing and treating loose teeth and tooth loss after long-term use.
The patents applying for the traditional Chinese medicine toothpaste are found by searching and analyzing, and the patents have different defects. Such as: the forest yao is faithful; xujuan' an; the invention discloses a traditional Chinese medicine toothpaste, which has the following publication numbers: CN107929167A, which is characterized by comprising natural borneol with the weight content of 3-5%; 3-5% of madder root; 1-3% of phellodendron bark; 1-3% of rhizoma atractylodis. The preparation of the materials adopts the conventional drying, crushing and sieving methods, and then is blended with a friction agent, a thickening agent, a foaming agent, other auxiliary agents and purified water according to the formula proportion, stirred to form paste, and then made into toothpaste by special equipment. After the traditional Chinese medicine toothpaste is used every day, halitosis, canker sore and gingivitis can be effectively prevented. It is easy to see that the traditional method of drying, crushing and sieving is adopted for the raw materials of the medicine, the process is relatively low, the quality control is inconvenient, and the content of the effective components is difficult to reach the treatment expectation.
The following steps are repeated: a field emblem; panjunpo; ruanqipin discloses a preparation method of traditional Chinese medicine toothpaste, with publication number of CN108295023B, and is characterized in that the traditional Chinese medicine toothpaste comprises the following components in parts by weight: 10-20 parts of bletilla, 5-15 parts of mangnolia officinalis, 6-12 parts of gallnut, 5-10 parts of radix ophiopogonis, 25-28 parts of calcium carbonate, 10-16 parts of glycerol, 4-16 parts of silicon dioxide, 3-17 parts of sodium lauryl sulfate, 2-5 parts of sodium carboxymethylcellulose, 1-3 parts of sodium benzoate, 2-4 parts of saccharin sodium, 1-3 parts of menthol and 50 parts of water; the preparation method comprises the following steps: (1) weighing rhizoma Bletillae, cortex Magnolia officinalis, Galla chinensis and radix Ophiopogonis according to formula, preparing corresponding extracts, and mixing to obtain Chinese medicinal extract; (2) preparing glue; (3) preparing paste; (4) grinding the paste twice, vacuum degassing, and standing to obtain the traditional Chinese medicine toothpaste. The traditional Chinese medicine toothpaste prepared by the method not only can clean teeth, but also has the effects of resisting bacteria, diminishing inflammation and relieving pain of gum, and can prevent teeth. The common bletilla pseudobulb, the officinal magnolia bark, the Chinese gall, the dwarf lilyturf tuber and other traditional Chinese medicines are extracted by ethanol, the preparation process of the patent is relatively complex, and the preparation process is not suitable for the traditional Chinese medicine property of some traditional Chinese medicine extracts, for example, the ethanol extraction of the Chinese gall and the dwarf lilyturf tuber is not suitable. The traditional Chinese medicines have weak anti-inflammatory and antibacterial abilities.
Disclosure of Invention
The invention aims to provide a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and a preparation method thereof, so as to solve the problems in the background technology.
In order to realize the purpose, the invention provides the following technical scheme:
a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy comprises 3-15 parts of honeysuckle flower extract, 3-15 parts of eupatorium extract, 3-15 parts of dipsacus asperoides extract, 2-15 parts of American agrimony extract and 2-15 parts of sanguisorba officinalis extract; 1-5 parts of propylene glycol, 10-60 parts of sorbitol, 1-10 parts of glycerol, 5-25 parts of silicon dioxide, 0.01-1 part of sodium fluoride, 0.1-1 part of titanium dioxide, 0.1-1 part of saccharin sodium, 0.5-2 parts of xylitol, 0.5-2 parts of carboxymethyl cellulose, 0.1-0.8 part of xanthan gum, 0-5 parts of sodium dodecyl sulfate, 0-1 part of preservative and the balance of deionized water.
According to a further technical scheme, the honeysuckle flower extract is 5-10 parts, the eupatorium extract is 5-10 parts, the dipsacus asperoides extract is 5-10 parts, the Agrimonia pilosa extract is 5-10 parts, and the sanguisorba officinalis extract is 5-10 parts; 3-5 parts of propylene glycol, 30-60 parts of sorbitol, 5-10 parts of glycerol, 10-25 parts of silicon dioxide, 0.5-1 part of sodium fluoride, 0.5-1 part of titanium dioxide, 0.5-1 part of saccharin sodium, 1-2 parts of xylitol, 1-2 parts of carboxymethyl cellulose, 0.4-0.8 part of xanthan gum, 2-5 parts of sodium dodecyl sulfate, 0.5-1 part of preservative and the balance of deionized water.
As a further technical scheme of the invention, the honeysuckle flower extract is 5 parts, the eupatorium extract is 5 parts, the dipsacus asperoides extract is 5 parts, the agrimony extract is 5 parts, and the sanguisorba officinalis extract is 5 parts; 3 parts of propylene glycol, 30 parts of sorbitol, 5 parts of glycerol, 10 parts of silicon dioxide, 0.5 part of sodium fluoride, 0.5 part of titanium dioxide, 0.5 part of saccharin sodium, 1 part of xylitol, 1 part of carboxymethyl cellulose, 0.4 part of xanthan gum, 2 parts of sodium dodecyl sulfate, 0.5 part of preservative and the balance of deionized water.
A preparation method of a Chinese herbal medicine toothpaste formula aiming at gingivitis and gingival atrophy comprises the following steps:
step 1, putting deionized water, propylene glycol, sorbitol and glycerol into a main emulsifying pot, and uniformly stirring at normal temperature;
step 2, putting honeysuckle flower extract, eupatorium extract, Chinese teasel root extract, American agrimony extract, garden burnet extract, silicon dioxide, sodium fluoride, titanium dioxide, saccharin sodium, xylitol, carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and preservative into a powder stirring cylinder, stirring uniformly, and adding into a main emulsifying pot;
step 3, stirring uniformly;
and 4, inspecting and filling.
As a further technical scheme of the invention, the stirring adopts uniform directional stirring.
Compared with the prior art, the invention has the beneficial effects that: the Chinese herbal medicine extract in the formula adopts the Chinese herbal medicine extract which is normally sold in the existing market as the raw material, avoids the wastes such as dregs and the like generated by decocting the raw material decoction pieces, has accurate weighing, and simultaneously has high medicine purity and is convenient for quality control. Modern industrial production is adopted, food-grade silicon dioxide components are added in a proper amount, and tooth stains are removed by mild friction; the trace food-grade sodium fluoride can clean and simultaneously strengthen teeth, and effectively reduce the occurrence of decayed teeth; the taste of the toothpaste is improved by matching with a trace amount of saccharin sodium and xylitol, so that the taste is more suitable for the taste of the public, and the product has better acceptance degree, can be used for a long time, is safe and has no toxic or side effect. Can effectively solve various oral inflammation problems, such as gingivitis, oral ulcer and halitosis.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy comprises 3 parts of honeysuckle flower extract, 3 parts of eupatorium extract, 3 parts of dipsacus asperoides extract, 2 parts of American agrimony extract and 2 parts of sanguisorba extract; 1 part of propylene glycol, 10 parts of sorbitol, 1 part of glycerol, 5 parts of silicon dioxide, 0.01 part of sodium fluoride, 0.1 part of titanium dioxide, 0.1 part of saccharin sodium, 0.5 part of xylitol, 0.5 part of carboxymethyl cellulose, 0.1 part of xanthan gum, 0 part of sodium dodecyl sulfate, 0 part of preservative and the balance of deionized water.
Example 2, a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy, 5 parts of honeysuckle flower extract, 5 parts of eupatorium extract, 5 parts of teasel root extract, 5 parts of American agrimony extract and 5 parts of sanguisorba extract; 3 parts of propylene glycol, 30 parts of sorbitol, 5 parts of glycerol, 10 parts of silicon dioxide, 0.5 part of sodium fluoride, 0.5 part of titanium dioxide, 0.5 part of saccharin sodium, 1 part of xylitol, 1 part of carboxymethyl cellulose, 0.4 part of xanthan gum, 2 parts of sodium dodecyl sulfate, 0.5 part of preservative and the balance of deionized water.
Example 3, a Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy, 15 parts of honeysuckle flower extract, 15 parts of eupatorium extract, 15 parts of teasel root extract, 15 parts of American agrimony extract and 15 parts of sanguisorba extract; 5 parts of propylene glycol, 60 parts of sorbitol, 10 parts of glycerol, 25 parts of silicon dioxide, 1 part of sodium fluoride, 1 part of titanium dioxide, 1 part of saccharin sodium, 2 parts of xylitol, 2 parts of carboxymethyl cellulose, 0.8 part of xanthan gum, 5 parts of sodium dodecyl sulfate, 1 part of preservative and the balance of deionized water.
The invention also discloses a preparation method of the Chinese herbal medicine toothpaste formula aiming at gingivitis and gingival atrophy, which comprises the following steps:
step 1, putting deionized water, propylene glycol, sorbitol and glycerol into a main emulsifying pot, and uniformly stirring at normal temperature;
step 2, putting honeysuckle flower extract, eupatorium extract, Chinese teasel root extract, American agrimony extract, garden burnet extract, silicon dioxide, sodium fluoride, titanium dioxide, saccharin sodium, xylitol, carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and preservative into a powder stirring cylinder, stirring uniformly, and adding into a main emulsifying pot;
step 3, stirring uniformly;
and 4, inspecting and filling.
The pharmacology of the traditional Chinese medicine raw materials used in the invention is as follows:
1. the honeysuckle flower contains various organic acids, flavonoids, triterpenoid saponins, iridoid, volatile oil and the like. It is sweet and cold in nature and enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials and dispelling wind and heat. Modern pharmacological research shows that the honeysuckle has the pharmacological effects of resisting bacteria, viruses, inflammation, oxidation, liver protection, immunity regulation and the like.
2. Radix Dipsaci contains triterpenoid saponin and its ester glycoside. The root contains alkaloid and volatile oil, the volatile oil has strong antibacterial ability, and the oil mainly contains ethyl propionate, 4-methylphenol, etc. It is slightly warm in nature, bitter and pungent in flavor. It enters liver and kidney meridians. Has the functions of dispelling wind and removing dampness, and strengthening tendons and bones, is clinically used for treating soreness and weakness of waist and knees caused by liver and kidney deficiency, nonunion fracture caused by trauma, and can also be used for treating menorrhagia and metrostaxis. Modern pharmacological research shows that the medicine has the functions of discharging pus, stopping bleeding, relieving pain and promoting tissue regeneration for mucosal ulcer.
3. Herba Eupatorii contains coumaric acid, coumarins essence, thymoquinol, taraxasterol, etc. volatile oil. It is fragrant, slightly bitter, pungent and mild in nature and flavor, and enters spleen, stomach and lung meridians. Has effects in eliminating dampness, activating spleen, stimulating appetite, relieving exterior syndrome, and relieving summer-heat. Can be used for treating damp turbidity obstruction in middle energizer, gastric fullness, emesis, halitosis, excessive salivation, summer-heat, damp exterior syndrome, fever, listlessness, chest distress, etc. Palmitate, taraxasterol acetate and the like are used as aromatic dampness-resolving spleen-enlivening drugs, and the clinical application range is wide. Recent researches show that the eupatorium has various chemical components and has various pharmacological effects of resisting inflammation, eliminating phlegm, resisting tumors and the like.
4. The western Agrimonia pilosa, also called Agrimonia pilosa, contains agrimonine (Agrimon-ins), and known 6 kinds of agrimonine A (Agrimon A), agrimonine B (Agrimon B), agrimonine C, agrimonine D, agrimonine E, and agrimonine Hei. It is bitter and astringent in flavor, slightly warm and mild. It enters heart and liver meridians. Has the function of astringing to stop bleeding, and is clinically used for various bleeding syndromes. Modern pharmacological studies show that the hot water or ethanol extract of herba et Gemma Agrimoniae has inhibitory effect on Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri and Salmonella typhi in test tube, and also has inhibitory effect on human type Bacillus tuberculosis.
5. Sanguisorba contains various tannin components such as sanguisorbain (sanguinin), etc., and sanguisorba root is used as a medicine, and has cold property, bitter and sour taste and no toxicity; it enters liver, lung, kidney and large intestine meridians. Modern medical research proves that the garden burnet has the effects of stopping bleeding, cooling blood, clearing away heat and toxic materials, astringing, arresting discharge and inhibiting various pathogenic microorganisms and tumors.
The traditional Chinese medicine formula of the toothpaste for treating stomatitis provided by the invention addresses both the symptoms and root causes, and is safe, reliable and free of side effects. In addition, the invention has the excellent effect that the selected medicinal materials are nontoxic and harmless substances with mild medicinal properties, can be used for a long time and can play roles in cleaning teeth and preventing and treating oral diseases.
The formula of the traditional Chinese medicine composition completely accords with the pharmacology of the traditional Chinese medicine:
1. in terms of the traditional Chinese medicine formula 'monarch, minister, assistant and guide': the eupatorium fortunei has the effects of eliminating dampness by fragrance and eliminating the breeding source of oral bacteria, is a monarch drug and is used for treating the root cause of the oral bacteria; the honeysuckle flower and the American agrimony have the functions of clearing away heat and toxic material, sterilizing and diminishing inflammation, and the American agrimony also has the function of stopping bleeding. Radix Dipsaci has effects of dispelling pathogenic wind, removing dampness, strengthening tendons and bones, expelling pus, stopping bleeding, relieving pain, and promoting tissue regeneration for treating mucosal ulcer. The three medicines are used as a ministerial medicine to treat the root; radix Sangusorbae has effects of stopping bleeding, cooling blood, clearing away heat and toxic materials, astringing, inducing astringency, and inhibiting various pathogenic microorganisms. Is an adjuvant drug, strengthens the treatment effect of a monarch drug and a ministerial drug, and does not need a messenger drug because the monarch drug and the ministerial drug directly act on the oral cavity and the gum. The five traditional Chinese medicine components are matched with each other, so that the gingivitis and gingival bleeding can be integrally conditioned, and both the symptoms and root causes can be treated.
2. In view of four flavors and five tastes: honeysuckle flower is sweet and cold in nature; eupatorium pungent and mild; dipsacus asperoides is slightly warm in nature and bitter and pungent in flavor; the western agrimony is bitter and astringent in taste, slightly warm and even; sanguisorba officinalis is slightly cold in nature, bitter and sour in taste and non-toxic. The five traditional Chinese medicines are mutually compatible, are warm and cool, have mild nature and taste and are easily accepted by human bodies.
3. From meridian tropism: honeysuckle flower belongs to the lung, heart and stomach channels; radix Dipsaci belongs to liver and kidney meridians; the eupatorium fortunei belongs to spleen, stomach and lung channels; the American agrimony enters liver and heart meridians; sanguisorba enters liver, lung, kidney and large intestine meridians. The five traditional Chinese medicines are mutually compatible, focus on the pathogenesis of gingivitis, dispel damp-heat in heart, spleen, stomach, lung, liver and gallbladder and large intestine channels, and discharge the damp-heat out of the body through the kidney. In addition, the dipsacus root has the functions of nourishing liver and kidney, expelling pus, stopping bleeding, easing pain and promoting tissue regeneration for treating mucosal ulcer. Is beneficial to the elimination of chronic gingivitis and the repair of atrophic gum.
In conclusion, the invention creatively compounds five traditional Chinese medicines with different natures and natures, ingeniously mixes the traditional Chinese medicine components and the components of toothpaste base material silicon dioxide and the like, and removes tooth stains by mild friction; the trace food-grade sodium fluoride can clean and simultaneously strengthen teeth, and effectively reduce the occurrence of decayed teeth; the taste of the toothpaste is improved by matching with a trace amount of saccharin sodium and xylitol, so that the taste is more suitable for the taste of the public, and the product has better acceptance degree, can be used for a long time, is safe and has no toxic or side effect. Can effectively solve the problems of gingivitis, halitosis, gingival atrophy and the like, and prevent the loose teeth or even tooth loss caused by gingival atrophy.
Typical case, a woman, 56 years old. The patient can be diagnosed after the gum is repeatedly bleeding for 3 years after the teeth are cleaned by the dental calculus. When the teeth are cleaned in stomatology in a certain hospital for 3 years, food stains are easy to remain in gaps among the teeth after the teeth are cleaned, the gum is bled when the teeth are automatically removed, bleeding occurs during each tooth cleaning, and the local part is slightly painful. There is no improvement when the medicines such as metronidazole and amoxicillin are taken orally in sequence. Gingival atrophy, mild redness of gingiva and sparse teeth were observed. The toothpaste is given to the toothpaste to brush teeth in the morning after eating and before sleeping. Gingival bleeding stopped after three days of use. The red swelling and pain disappeared in one week. The gum atrophy disappears after the gargling is kept for half a year.
Gingivitis is mainly located in free gingiva and gingival papilla, and the pathogenesis of gingivitis is mainly the dysbiosis of microbial flora on the surface of teeth, dental plaque is stubborn, conventional tooth brushing is difficult to clean, early-stage tooth brushing is not easy to detect, and the phenomena of inflammation, swelling, bleeding and the like of a patient occur along with the occurrence of inflammation. Chronic gingivitis and gingival atrophy are not cured for a long time and are easy to develop.
Chronic gingivitis is a chronic inflammation of the oral cavity, and the symptoms of bleeding of the gums are particularly obvious after tooth brushing. In the later stage, the gum atrophy and the teeth loose and fall off early.
Aiming at gingivitis, the treatment of the toothpaste (an observation group) and a certain brand of toothpaste (a control group) are compared and researched. The report is as follows:
general data:
60 gingivitis patients were selected and randomly divided into control and observation groups, 30 each. General data are shown in Table 1
1.1, table 1 general data comparison results:
note: no statistical difference in sex, age and course of disease was observed between the two groups (P > 0.05).
1.2, inclusion and exclusion criteria:
inclusion criteria were: the diagnostic standard of gingivitis is met; and signing the related file with informed consent. Exclusion criteria: those with liver and kidney dysfunction, diabetes, and those who are not matched with the present researchers.
1.3, method:
the toothpaste is adopted in the observation group, and 1-2 ml of toothpaste is taken out every time for brushing teeth for not less than 5 minutes after eating and before sleeping; the control group adopts a certain brand of toothpaste and the method is the same as that of the observation group; the observation time was 7 days, and the treatment effect was evaluated after 7 days.
1.4, statistical analysis:
the data are counted and processed by SPSS 22.0, the measured data are expressed as (+/-s), the counting data are expressed as (%), the data are compared by a t test or a x 2 test, and the difference is obvious when P < 0.05.
As a result:
the total effective rate of gingivitis and periodontitis by an observation group is 100%, the total effective rate of a control group is 25.0%, the total effective rate of the observation group is obviously higher than that of the control group, and the difference has statistical significance (P is less than 0.05; see table 2).
Table 2: gingivitis and periodontitis efficacy comparison [ n,% ];
it will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (5)
1. The Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy is characterized by comprising 3-15 parts of honeysuckle flower extract, 3-15 parts of fortune eupatorium herb extract, 3-15 parts of dipsacus asperoides extract, 2-15 parts of American agrimony extract and 2-15 parts of garden burnet extract; 1-5 parts of propylene glycol, 10-60 parts of sorbitol, 1-10 parts of glycerol, 5-25 parts of silicon dioxide, 0.01-1 part of sodium fluoride, 0.1-1 part of titanium dioxide, 0.1-1 part of saccharin sodium, 0.5-2 parts of xylitol, 0.5-2 parts of carboxymethyl cellulose, 0.1-0.8 part of xanthan gum, 0-5 parts of sodium dodecyl sulfate, 0-1 part of preservative and the balance of deionized water.
2. The Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy according to claim 1, wherein the toothpaste comprises 5-10 parts of honeysuckle flower extract, 5-10 parts of eupatorium fortunei extract, 5-10 parts of dipsacus asperoides extract, 5-10 parts of American agrimony extract and 5-10 parts of sanguisorba officinalis extract; 3-5 parts of propylene glycol, 30-60 parts of sorbitol, 5-10 parts of glycerol, 10-25 parts of silicon dioxide, 0.5-1 part of sodium fluoride, 0.5-1 part of titanium dioxide, 0.5-1 part of saccharin sodium, 1-2 parts of xylitol, 1-2 parts of carboxymethyl cellulose, 0.4-0.8 part of xanthan gum, 2-5 parts of sodium dodecyl sulfate, 0.5-1 part of preservative and the balance of deionized water.
3. The Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy according to claim 1, wherein the honeysuckle flower extract is 5 parts, the eupatorium fortunei extract is 5 parts, the dipsacus asperoides extract is 5 parts, the agrimony western extract is 5 parts, and the sanguisorba officinalis extract is 5 parts; 3 parts of propylene glycol, 30 parts of sorbitol, 5 parts of glycerol, 10 parts of silicon dioxide, 0.5 part of sodium fluoride, 0.5 part of titanium dioxide, 0.5 part of saccharin sodium, 1 part of xylitol, 1 part of carboxymethyl cellulose, 0.4 part of xanthan gum, 2 parts of sodium dodecyl sulfate, 0.5 part of preservative and the balance of deionized water.
4. A preparation method of a Chinese herbal medicine toothpaste formula aiming at gingivitis and gingival atrophy is characterized by comprising the following steps:
step 1, putting deionized water, propylene glycol, sorbitol and glycerol into a main emulsifying pot, and uniformly stirring at normal temperature;
step 2, putting honeysuckle flower extract, eupatorium extract, Chinese teasel root extract, American agrimony extract, garden burnet extract, silicon dioxide, sodium fluoride, titanium dioxide, saccharin sodium, xylitol, carboxymethyl cellulose, xanthan gum, sodium dodecyl sulfate and preservative into a powder stirring cylinder, stirring uniformly, and adding into a main emulsifying pot;
step 3, stirring uniformly;
and 4, inspecting and filling.
5. The method for preparing a herbal toothpaste formulation for gingivitis and gingival atrophy according to claim 4, wherein the stirring is performed by directional stirring at a constant speed.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114177123A (en) * | 2022-01-06 | 2022-03-15 | 九江学院 | Aromatic Chinese herbal medicine toothpaste and preparation method thereof |
| CN114177123B (en) * | 2022-01-06 | 2023-04-25 | 九江学院 | Fragrant Chinese herbal medicine toothpaste and preparation method thereof |
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Application publication date: 20211022 |