CN112137928A

CN112137928A - Multi-effect toothpaste and preparation method thereof

Info

Publication number: CN112137928A
Application number: CN202011005580.5A
Authority: CN
Inventors: 黄佐良; 陈习坚
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-09-22
Filing date: 2020-09-22
Publication date: 2020-12-29

Abstract

The invention provides a multi-effect toothpaste and a preparation method thereof, the toothpaste takes four aromatic traditional Chinese medicines of mint, agastache rugosus, rosemary and thyme and active polypeptide as main components, the aromatic traditional Chinese medicines can sterilize and remove viruses, and the active polypeptide can repair damaged cells and enhance the immune function. The toothpaste has the effects of resisting bacteria and diminishing inflammation, treating dental ulcer, and improving oral problems such as swelling and aching of gum, bleeding of gum, atrophic gingivitis and the like caused by gum injury due to long-term chronic inflammation and other reasons of the gum, wherein the swelling and aching of gum and the bleeding of gum are caused by gingivitis, periodontitis and the like; can also effectively prevent viral influenza, upper respiratory infection and the like. The main effective components of the toothpaste adopt traditional Chinese medicine components and active polypeptide with cell repairing effect, so that the toothpaste has no toxic or side effect and is more environment-friendly and safer.

Description

Multi-effect toothpaste and preparation method thereof

Technical Field

The invention relates to the technical field of oral health care, in particular to a multi-effect toothpaste and a preparation method thereof.

Background

The oral cavity is the initial part of the digestive tract of the human body, is connected with the throat part of the human body and contains organs such as tongue, teeth and the like inside the oral cavity. In daily life, people often suffer from symptoms such as halitosis, toothache, oral ulcer and dry mouth, and the like, which brings certain influence to the daily life of people. For example, oral mucosal diseases, which are the lesions of the oral mucosa, and the specific symptoms are: ulceration of the mouth and tongue, dry and cracked tongue body, hoarseness, dry mouth and bitter taste, which in turn causes oral diseases such as lichen planus, stomatitis, recurrent aphtha, cheilitis and the like, resulting in difficult eating, painful oral cavity and embarrassment, and once the disease condition is caused, the oral diseases are repeatedly attacked. And can cause various complications in vivo, and directly affect the physical health, life and work of patients. At present, western medicines are usually applied to the disease clinically to control symptoms, but the disease is difficult to be cured radically, and the western medicines are one of the major problems of the oral diseases.

In addition, plaque is also common affecting oral health. The main culprit of dental caries and periodontal disease is dental plaque, which is an extremely thin, very sticky, colorless film formed by the aggregation of a large number of bacteria, which is generally invisible to the eye, and which adheres very tightly to the tooth surface and cannot be removed by gargling. Bacteria in the plaque multiply to produce toxins, which can cause destruction of the teeth and periodontal tissues. If the bacterial plaque on the tooth surface is not removed in time, hard dental calculus is formed for a long time, and harmful stimulation is formed on the gum.

In addition, the oral cavity is also a key part for preventing respiratory infectious diseases. Infectious diseases of the respiratory tract, including influenza, acute viral and bacterial pharyngitis, laryngitis, sphagitis, tonsillitis, tracheitis, pneumonia and the like, seriously affect the health and life safety of human bodies. In particular, recent new coronavirus pneumonia (Corona Virus Disease 2019, COVID-19) epidemic situation is prevalent in the world, and the Disease is proved to be acute respiratory infectious Disease caused by 2019 new coronavirus infection. Preventive measures also include daily oral hygiene precautions. In daily life, if toothpaste with antiviral related efficacy is adopted for oral health care, the toothpaste can also play a certain role in preventing viral acute respiratory infectious diseases.

In recent years, due to changes of living habits and consumption concepts of people, more requirements are put forward on toothpaste, various toothpastes with health care functions emerge in the market, particularly, the Chinese herbal medicine toothpaste has a huge market share, and the Chinese herbal medicine toothpaste has the health care functions of inhibiting harmful bacteria in the oral cavity, refreshing breath, protecting teeth, preventing and treating oral diseases and the like. At present, the toothpaste containing Chinese herbal medicines is widely accepted for preventing and treating gingivitis, and has the characteristics of safety, simple operation, convenient carrying and the like. Along with the continuous improvement of living standard of people, more and more people have higher demands on the health of oral diseases, so that the toothpaste which has multiple functions, such as comprehensive effects of removing bacterial plaque, preventing various oral and respiratory diseases and repairing oral damaged mucosa, is safe and nontoxic and can ensure the demands on oral health is sought, and the toothpaste becomes a product which is urgently needed in the life of people.

However, the toothpaste containing the traditional Chinese medicine composition in the current market has a single formula or insufficient functionality, or the curative effect is not very obvious. For example, cn201710210977.x, a toothpaste made from rhizoma Bletillae comprises the following Chinese medicinal materials: bletilla striata, radix ophiopogonis, bamboo leaves, chrysanthemum, pseudo-ginseng, rangooncreeper fruit and purslane can achieve the effects of sterilization and inflammation resistance, but do not have the effects of promoting the restoration of oral cavity injury mucosa and preventing viruses. In addition, as CN201510530268.0 toothpaste with the effects of stopping bleeding and protecting gum and a preparation method thereof, the combination of the pseudo-ginseng extract and tranexamic acid enables the toothpaste to have enhanced hemostatic effect and multidirectional gum protection effect. But the toothpaste also has no functions of promoting the repair of oral cavity damaged mucosa and resisting virus and preventing cold. For another example, CN 201210196187.8A biological environment-friendly antiviral anti-cold toothpaste and its preparation method, the toothpaste comprises the following components: alkyl glycoside (APG), precipitated silica, lysozyme, neutral protease, hydrolyzed protein, immunoglobulin, recombinant human epidermal growth factor, strontium chloride, sorbitol, butyl paraben, CMC, xanthan gum, glucosidase, skin penetrant, etc. The toothpaste has antiviral and cold preventing effects, but has no recorded oral mucosa injury repairing and bleeding stopping effects and gum protecting effects. For another instance, CN201711120602.0 is a traditional Chinese medicine toothpaste with the efficacy of preventing oral ulcer and repairing oral mucosa, the invention is based on the pharmacodynamic principle of four traditional Chinese medicines of phellodendron, massicot, pittosporum clypearia and sowthistle, and is compounded with efficacy accelerator to achieve the effects of clearing away heat and toxic material, relieving swelling and pain, removing necrotic tissue and promoting granulation, astringing and stopping bleeding in a synergistic manner, and the toothpaste has the effects of repairing damaged oral mucosa and preventing oral ulcer. But the toothpaste does not have the effects of resisting virus, preventing cold and strengthening teeth and protecting gum.

In conclusion, no toothpaste with the above multiple effects exists in the market at present. Therefore, there is a need to develop toothpaste with multiple effects of resisting bacteria and diminishing inflammation, treating oral ulcer, improving oral problems such as swelling and aching of gum, bleeding gum, atrophic gingivitis and the like caused by gingivitis, periodontitis and the like, and effectively preventing viral cold, upper respiratory infection and the like.

Disclosure of Invention

Aiming at the defects of the prior art, a great number of tests are carried out to develop a new toothpaste with multiple effects, the toothpaste contains a plurality of aromatic traditional Chinese medicines and active polypeptide compositions, and has the effects of resisting bacteria and diminishing inflammation, treating dental ulcer, and improving oral problems such as gum swelling and pain, gum bleeding, atrophic gingivitis and the like caused by gum injury due to long-term chronic inflammation of gum and other reasons caused by gingivitis, periodontitis and the like; can also effectively prevent viral influenza, upper respiratory infection and the like.

The invention is realized by the following technical scheme that the effective components of the toothpaste comprise an aromatic traditional Chinese medicine composition and an active polypeptide liquid; the fragrant traditional Chinese medicine composition is prepared from mint, agastache rugosus, rosemary and thyme according to a weight ratio of 2.4-3: 2.3-2.8: 2-2.6; the aromatic traditional Chinese medicine composition accounts for 5-25% of the total weight of the toothpaste; the active polypeptide liquid is prepared from acetyl hexapeptide, carnosine (beta-alanyl-L-histidine) and oligopeptide 32 according to the weight ratio of 1: 1; the active polypeptide liquid accounts for 5-30% of the total weight of the toothpaste.

Preferably, the aromatic traditional Chinese medicine composition accounts for 15-20% of the total weight of the toothpaste; the active polypeptide liquid accounts for 8-15% of the total weight of the toothpaste.

Preferably, the aromatic traditional Chinese medicine composition is as follows: the herba Menthae, herba Agastaches, herba Rosmarini officinalis and herba Thymi vulgaris in a weight ratio of 2.6:2.5: 2.4.

The toothpaste with multiple efficacies also comprises an abrasive, a humectant, a thickening agent, a foaming agent, a preservative, a sweetening agent and other additives.

The multi-effect toothpaste comprises the following components in percentage by weight: 5 to 25 percent of aromatic traditional Chinese medicine composition, 5 to 30 percent of active polypeptide liquid, 20 to 50 percent of abrasive, 10 to 40 percent of humectant, 0.5 to 2 percent of thickening agent, 1 to 5 percent of foaming agent, 0.1 to 0.4 percent of preservative, 0 to 0.3 percent of sweetening agent, 0 to 5 percent of other additives and the balance of water.

Preferably, the multiple-effect toothpaste comprises 21% of the aromatic traditional Chinese medicine composition, 9% of the active polypeptide liquid, 26% of the abrasive, 30% of the humectant, 1.5% of the thickening agent, 3% of the foaming agent, 0.4% of the preservative, 2.3% of other additives and the balance of water.

The abrasive is one or a mixture of more of rice husk ash, titanium dioxide, calcium carbonate, calcium hydrophosphate dihydrate, anhydrous calcium hydrophosphate, calcium pyrophosphate, silicon dioxide, aluminum hydroxide, alumina trihydrate, calcite powder and chlorite. The humectant is one or a mixture of sorbitol, glycerol, propylene glycol or polyethylene glycol. The thickener can be one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, xanthan gum, hydroxypropyl guar gum and carrageenan. The foaming agent is sodium dodecyl sulfate, cocamidopropyl betaine, sodium lauroyl sarcosinate and the like. The antiseptic is one or more of triclosan, methyl paraben, ethyl paraben and sodium benzoate. The other additives are one or a mixture of more of a coloring agent, an antioxidant, a pH regulator and a taste modifier; wherein the taste modifier is one or more of chitosan, saccharin sodium, aspartame, sucralose and sodium chloride; the colorant is at least one of chlorophyll, titanium dioxide, allura red pigment, brilliant blue pigment, lemon yellow pigment and pearl powder; the pH regulator is one or more of sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate and sodium silicate; the antioxidant is one or more of Butyl Hydroxy Anisol (BHA), dibutyl hydroxy toluene (BHT), stannous chloride, phytic acid, vitamin C, vitamin E and vitamin K.

Preferably, the friction agent is prepared from rice hull ash nano micro powder and calcium carbonate according to the weight ratio of 1-4: 1 are mixed. The rice hull ash nano micro powder is obtained by crushing white ash powder after rice hulls are whitened by burning to a nano level, and contains silicon dioxide, high silica, potassium, sodium and other components.

The preparation process of the multi-effect toothpaste comprises the following steps: mixing the aromatic Chinese medicinal composition superfine powder, active polypeptide liquid, humectant and antiseptic, adding into deionized water, stirring to obtain deionized water solution, adding thickener, friction agent, foaming agent and other additives, mixing, high-speed stirring and grinding in a three-in-one vacuum paste making machine for 25-40 min, vacuum degassing, adding other materials, stirring and grinding for 10-25 min, mixing to obtain toothpaste, aseptically packaging, and packaging.

Mixing the aromatic Chinese medicinal composition superfine powder, active polypeptide liquid, humectant and antiseptic, adding into deionized water, stirring to obtain deionized water solution, adding thickener, friction agent, foaming agent and other additives, mixing, high-speed stirring and grinding in a three-in-one vacuum paste making machine for 25-40 min, vacuum degassing, adding other materials, stirring and grinding for 10-25 min, and mixing to obtain toothpaste. The preparation method comprises the steps of aseptic filling, subpackaging and packaging.

Wherein the superfine powder of the aromatic Chinese medicinal composition is 1000 mesh superfine powder; the friction agent is prepared by cleaning rice hull, air drying or oven drying, burning in a furnace for whitening, decarburizing, burning to obtain white rice hull ash, micronizing to obtain 500-mesh rice ash nanometer micropowder, and mixing with calcium carbonate at a weight ratio.

The efficacy of the drugs used in the present invention is described below:

aromatic plants are a group of plants having properties common to both medicinal plants and natural aromatic plants. In recent scientific research, aromatic plants contain various medicinal components and aromatic components, as well as antioxidant substances, antibacterial substances and the like, and the odor released by some aromatic plants can kill bacteria and viruses and expel mosquitoes and flies. Aromatic plants have a history of widespread use in healthcare. As early as more than 1000 years ago, the records of 'smelling fragrance to cure diseases' and 'removing odor and avoiding epidemic' exist in the Shen nong Ben Cao Jing and other medical monographs. Volatile plant essential oil emitted by aromatic plants, after being inhaled by human beings, the molecules of the essential oil firstly enter the system of the marginal lobe of the brain, and the molecules enter the alveoli along with the inhaled air to be directly absorbed and then are transmitted to the blood to flow to the heart, and directly act on the coronary artery and microcirculation of the nourishing heart and spread all over the body. Meanwhile, the aromatic molecules directly act on nasal mucosa, nasopharynx and laryngopharynx, trachea and bronchus mucosa, so that the natural protective barrier effect is achieved, respiratory tract infection and infectious diseases can be prevented, and the human body immunity function can be improved.

Agastache rugosa (Agastache rugosa), also known as Vanilla repens, a perennial aromatic herb Agastache rugosa has a long history of being used for epidemic prevention and disease treatment. As early as in the book of materia medica, it is pointed out that "Huo Xiang, its qi is fragrant and good at moving stomach qi, so as to regulate middle energizer and cure vomiting and cholera, so as to quicken qi, remove filth and stuffiness, that" Xiang can harmonize five internal organs, and Xin can relieve nine orifices, so if it is used for post disease, it does not invade exogenous pathogenic factors internally, and has the force of governing healthy qi "; in Ben Cao Zheng Yi (Chinese materia medica treatment), Huo Xiang is also called to avoid foul and eliminate epidemic qi. Can be used for preventing common cold and respiratory tract infection, and has effects in relieving vomit, promoting stomach qi circulation, relieving abdominal distention, and relieving summer-heat.

The mint (Mentha arvensisi) is also called wild mint, is used for detoxifying, dispelling wind heat, treating influenza, headache, conjunctival congestion and sore throat, diminishing inflammation and relieving pain in traditional Chinese medicine, has aromatic odor, refreshment and energy multiplication, has extremely strong sterilization and virus removal effects, can prevent viral influenza and oral diseases, and also has the effects of refreshing oral cavity and removing halitosis.

The thyme, the volatile oil in the herb contains thymol, carvacrol and other aromatic substances, and also contains saponin, ursolic acid, green collagen and flavonoid compounds. The volatile oil, especially Moschus camphor, has antiseptic, disinfectant and antibacterial effects, and can be used for sterilizing oral cavity and throat, and inhibiting Staphylococcus aureus and Escherichia coli. It has effects in inhibiting gram-positive and gram-negative bacteria and fungi, killing respiratory bacteria, eliminating phlegm, and preventing and treating respiratory infection, nasopharynx, pharyngolaryngitis, tracheobronchitis, and pertussis.

Rosemary contains abundant rosemary oil, antioxidant, flavonoid and triterpenes. Can be used for treating blood malignancy tumor and cardiovascular disease, inhibiting HIV infection, and preventing respiratory infection. The rosmarinic acid has effects of resisting blood platelet aggregation and increasing fibrinolytic activity to achieve antithrombotic effect, and can be used for preventing cardiovascular and cerebrovascular embolism. The rosmarinic acid has obvious antipyretic, analgesic and anti-inflammatory effects, can improve the activity of antioxidant enzyme, scavenge free radicals, reduce the generation of oxygen lipid, and has the effect of delaying aging.

The rosemary, the wrinkled giant hyssop, the thyme, the mint and the like in the invention play the following main roles: 1. can kill or inhibit the growth and reproduction of bacteria and viruses on respiratory tract, nose, nasopharynx, oropharynx, and laryngopharynx tracheal bronchial mucosa. Preventing various diseases and epidemic diseases of respiratory system. 2. Relieving flatulence, dyspepsia, nausea, emesis, chest distress, etc. 3. Refreshing brain, relieving fever and pain. 4. Cleaning oral cavity, and eliminating halitosis.

The rice hull ash contains potassium carbonate, cellulose, lignin, silicon dioxide (70%), sodium, potassium, high ash content (7% -9%) and high silica (about 20%), and has good toughness, porosity and low density (112-144 kg/m)³). The white rice husk ash ultrafine powder is added into toothpaste according to a certain proportion to have a very good effect as a friction agent. The components of sodium, potassium and calcium in the rice hull ash powder rub teethHas the help effect that the silicon dioxide has obvious erosion effect on tartar, wipes off soft on the surface of teeth and relieves the foreign substances such as dental stain, dental plaque, dental calculus and the like. The rice husk white ash nanometer micropowder has moderate particle texture, and does not damage enamel and dentin. Can be used as an ideal abrasive for toothpaste. Moreover, the price of the toothpaste friction agent prepared from the rice hull ash is low, the preparation is simple and convenient, and the effect of changing waste into valuables is achieved.

According to the invention, the research shows that the friction agent prepared by mixing the rice hull ash nano micro powder and the calcium carbonate according to the weight ratio has excellent effect. There are two important indexes for evaluating toothpaste abrasive: firstly, the cleaning effect of the friction on tooth stains can wipe off soft dirt on the surfaces of teeth and lighten tooth stains. PCR is widely used in European and American toothpaste industry to evaluate the effect of abrasives or toothpaste on physically removing extrinsic stains. Second, the abrasives have moderate abrasion values for enamel and dentin, and are usually measured by a radioactive dentin examination method, which is abbreviated as RDA value. The ideal toothpaste abrasive should have a proper PCR value and a lower RDA value, not only has good cleaning effect, but also does not damage enamel and dentin. The existing abrasive cleans the enamel by means of physical friction, and high cleaning effect is often accompanied with abrasion of the enamel. Or the PCR value is low, and the cleaning effect cannot be achieved; or the PCR value is high, the cleaning effect is good, but the RDA value is also high, the damage to enamel and dentin is large, and the long-term use can cause wedge defect of teeth and influence the oral health. Some of the abrasives currently in common use are calcium carbonate (Caco)₃) Calcium hydrogen phosphate dihydrate (CaHpo)₄) Calcite powder (Caco)₃) And the RDA value of the abrasive is higher, the dentin can be damaged by excessive friction, and the RDA value of the abrasive generally does not exceed 250.

The weight ratio of the developed rice hull ash nano micro powder to calcium carbonate is 1-4: 1 the blend is excellent as an abrasive. Wherein the ratio of the rice hull ash nano micro powder to the calcium carbonate is 2:1 is best as an abrasive when mixed. Tests prove that the rice hull white powder abrasive has moderate PCR value and RDA value and moderate abrasive particle diameter, and is the most ideal toothpaste abrasive.

At present, no document reports that the toothpaste and the toothpaste with similar formula are applied to oral health are available. The toothpaste with multiple effects contains various aromatic traditional Chinese medicines capable of sterilizing and removing viruses and active polypeptides capable of repairing damaged cells and enhancing immune function, so that the toothpaste with multiple effects has the following beneficial effects:

(1) the toothpaste of the invention is added with active polypeptide liquid prepared from acetyl hexapeptide, carnosine and oligopeptide 32, and has good anti-inflammatory and repairing effects. The oral cavity and dental diseases such as gingivitis, periodontitis, gingival atrophy, oral ulcer and the like can be better prevented and treated, and particularly the oral ulcer treatment effect is obvious.

(2) The toothpaste of the invention has the functions of sterilization and antivirus. Four aromatic Chinese medicinal materials of rosemary, agastache rugosus, thyme and mint are subjected to nano-technology ultramicro to 1000-mesh powder to serve as effective components, so that bacteria and viruses can be killed, and viral respiratory infectious diseases and various bacterial infectious respiratory inflammations can be prevented and treated. In the process of using the toothpaste, the medicine in the toothpaste can be quickly absorbed through the oral cavity, and the medicine components can be slowly accumulated in the human body after long-term use, so that the immunity and the antiviral capability of the human body can be gradually improved. Experimental observations have found that the incidence of colds consistently used for more than one year on demand is significantly lower than the average.

(3) The rice hull ash nano micro powder and the calcium carbonate are used as the abrasive, so that dental plaque is effectively removed, enamel is not damaged, the tooth is gently cleaned, and the tooth and the gum are protected. Due to the adoption of the unique friction agent, the granularity and the friction value are optimal. Therefore, the toothpaste of the invention has better effects of removing dental plaque, cleaning and polishing teeth than the common toothpaste, but does not excessively abrade enamel. Moreover, the rice hull ash nano micro powder can absorb water to expand in the paste preparation process, so that the traditional Chinese medicine ultra-micro powder and the active polypeptide liquid can be absorbed into the paste to form certain protection, and the large loss of effective components in the preparation, storage and use processes can be effectively prevented. And the effective components are further released by the friction between the toothbrush and the teeth in the process of brushing the teeth, so that the effective components in the toothpaste can better act on the teeth, and the tooth brushing effect and the sensory experience are improved. The nano-grade micro-powder has better adsorption property after water absorption and expansion than common friction agents, can effectively remove stains, has softer texture and cannot damage tooth glaze. The preparation process can reduce cost and has no adverse effect on other functional components.

(4) The toothpaste ingredients of the invention are safer, the main effective ingredients adopt traditional Chinese medicine components and active polypeptide with cell repairing function, and the toothpaste has no toxic or side effect. The components are more environment-friendly and safer. Therefore, the toothpaste is also suitable for the oral cavity and tooth health care of teenagers and children.

Detailed Description

The present invention will be described in detail with reference to specific embodiments in order to clearly understand the objects, technical features, advantages and novel points of the present invention.

Example 1 preparation of a multiple efficacy toothpaste

The formula and the dosage of the toothpaste are detailed in the unit proportion of 11000 g in the table

The preparation method comprises the following steps:

the method comprises the following steps: the preparation method comprises the steps of preparing medicinal materials of mint, agastache rugosus, thyme and rosemary according to the cleaning operation procedures of the traditional Chinese medicinal materials, processing the medicinal materials into 1000-mesh superfine powder by adopting a nanometer technology, and weighing and mixing the superfine powder into the aromatic traditional Chinese medicine composition for later use according to the weight ratio.

Step two: mixing acetyl hexapeptide, carnosine (beta-alanyl-L-histidine) and oligopeptide 32 according to the proportion of 1:1:1 to prepare active polypeptide liquid for later use.

Step three: cleaning rice hulls, airing or drying, placing the rice hulls in a furnace for whitening combustion, decarburizing and burning to prepare white rice hull ash with certain chemical activity, carrying out superfine grinding by a ball mill to obtain 500-mesh rice ash nano micro powder, and mixing the nano powder with calcium carbonate according to a weight ratio to serve as a friction agent for later use.

Step four: mixing the aromatic Chinese medicinal composition superfine powder, active polypeptide liquid, humectant and antiseptic, adding into deionized water, stirring to obtain deionized water solution, adding thickener, friction agent, foaming agent and other additives, mixing, high-speed stirring and grinding in a three-in-one vacuum paste making machine for 25-40 min, vacuum degassing, adding other materials, stirring and grinding for 10-25 min, mixing to obtain toothpaste, aseptically packaging, and packaging.

Example 2 preparation of a multiple efficacy toothpaste

The toothpaste formulations and amounts are detailed in table 2, and the preparation method is the same as example 1.

TABLE 2 toothpaste prescription 1000g as unit proportion

Example 3 preparation of a multiple efficacy toothpaste

The toothpaste formulations and amounts are detailed in table 3, and the preparation method is the same as example 1.

TABLE 3 toothpaste prescription 1000g as unit proportion

Example 4 preparation of a multiple efficacy toothpaste

The toothpaste formulations and amounts are detailed in table 4, the preparation method is the same as example 1.

TABLE 4 toothpaste prescription 1000g as unit proportion

Example 5 preparation of a multiple efficacy toothpaste

The toothpaste formulations and amounts are detailed in table 5, the preparation method is the same as example 1.

TABLE 5 toothpaste prescription 1000g as unit proportion

The products obtained in examples 1 to 5 were tested according to QB8372-2008, with the following criteria: paste stability: the paste is not abnormal in a 40 ℃ oven for 4.5 months, no liquid is separated, and the fragrance and the color are normal. Color: the color faded in the 40 ℃ oven for 145 days. pH value: 7.0, the physicochemical index accords with the QB8372 standard.

According to QB8372-2008 standard, various sensory indexes, physicochemical indexes and health indexes of the toothpaste completely meet QB8372-2008 standard, meanwhile, samples are placed at-10 ℃ and 48 ℃ for 48 hours respectively, and are taken out and recovered to room temperature, the paste is found to be uniform, free of foreign matters and deterioration, and the freezing resistance and heat resistance of the paste are very good.

The toothpastes prepared in examples 1 to 5 exhibited uniform color and luster, and the paste extruded through the tube body remained a cylindrical strip-shaped paste, which did not exhibit a water phenomenon even after a centrifugal test was performed at a rotation speed of 3500 rpm for 45 minutes, and remained a cylindrical strip-shaped paste after a cold and heat test at a constant temperature of 45 ℃ for 60 days or at a constant temperature of 5 ℃ for 60 days, confirming that the toothpastes provided by the present invention had excellent stability.

The above toothpaste formulations of examples 1-5 were studied in depth and the results showed that:

1. the weight ratio of the four aromatic traditional Chinese medicines including the mint, the agastache rugosus, the thyme and the rosemary is optimal in the ratio of 2.6:2.5:2.5:2.4, the fragrance is natural, more attractive and more suitable for the public, and the anti-inflammatory and bactericidal effects are also better.

2. The abrasive in the toothpaste is prepared by mixing the rice hull ash white ultrafine powder and calcium carbonate according to a ratio of 2:1, the abrasive has a better friction effect, and the abrasive for removing dental plaque on the surface of teeth is better than the abrasive with other ratios.

3. The proportioning of each component is best according to the proportioning in the fourth table of the example.

It should be noted that, in order to better compare the weight ratios of the four aromatic traditional Chinese medicines and the ratios of the abrasives, the toothpaste of the embodiments 1 to 5 of the present invention comprises the following other components: the humectant, thickener, foaming agent, preservative, sweetener, and other additives are the same. However, it is well known to those skilled in the art that it is obvious that the humectant may be one or a mixture of glycerin, propylene glycol or polyethylene glycol in addition to sorbitol; the thickener can be one or more of hydroxyethyl cellulose, carbomer, xanthan gum, hydroxypropyl guar gum and carrageenan besides sodium carboxymethylcellulose; the foaming agent can be sodium lauryl sulfate, cocamidopropyl betaine and the like besides sodium lauroyl sarcosine; the antiseptic can be one or more of triclosan, methyl paraben and ethyl paraben; the other additives can be one or more of common colorant, antioxidant, pH regulator and taste modifier besides vitamin E and vitamin K.

Experimental example I, the toothpaste provided by the invention is used for observing the treatment effect on chronic gingivitis and periodontitis.

Patients with chronic gingivitis and periodontitis who are generally in good general condition at age 14-70 years old are selected. Clinical examination diagnosed chronic gingivitis and periodontitis patients.

The main cause of gingivitis and periodontitis is the accumulation of plaque (a sticky substance consisting of bacteria, saliva and food debris) on the teeth. Bacteria in the tartar and plaque, and toxins produced by the bacteria, infect and stimulate the gums to form gingivitis. Periodontitis develops when the infection progresses to the ligaments and bone tissue surrounding the teeth. Periodontitis is a cause of loose and lost teeth. Therefore, gingivitis and periodontitis need to be treated in time.

Firstly, testing personnel:

172 volunteers with varying degrees of gingivitis and periodontitis were randomized into two groups. One group was 86 persons in the test group (toothpaste according to example 4 of the present invention). One group was 86 persons as a control group (ordinary gum-protecting toothpaste series).

II, a test method:

the test group members brushed their teeth using the toothpaste of the present invention. The control group uses common toothpaste, and adopts half an hour of brushing teeth before breakfast and after dinner, and 3g of toothpaste is used each time, and the brushing teeth are brushed for about 5 minutes with moderate force.

The effects of gingivitis and plaque were observed and recorded for the test and control groups. During the experiment, no relevant adverse reaction occurs in two groups of subjects. Both groups of subjects used the Gingival Index (GI) and gingival plaque index (PLI) as observations and were reviewed, examined and enrolled for treatment efficacy after two weeks.

Scoring criteria for the gingival index (G1) among others: 0 ═ gum health. 1 ═ gingival mild inflammation: the color of the gum is slightly changed and slightly edematous, and bleeding is not detected. 2 ═ moderate inflammation of the gums: the gum is red, edema is bright, and bleeding is detected. 3 ═ gingival severe inflammation: the gums are markedly inflamed or ulcerated and have a tendency to bleed spontaneously.

Gingival area plaque index (PLI) score criteria: 0. no plaque is found in the gingival margin; 1. thin bacterial plaque is on the tooth surface of the gingival margin area, and the bacterial plaque is scraped out by the surface of the tooth when the vision examination is invisible; 2. moderate amounts of plaque were visible at the gingival margin or adjacent surface.

Thirdly, test results:

the observations of the chronic gingivitis (G1 and PL1) test group versus the control group are shown in the following table:

table I comparison of G1 and PL1 efficacy between two groups of patients with chronic gingivitis and periodontitis before and after treatment

Statistical analysis of the data in the experimental group and the control group showed that the effect of the experimental group was significantly better than that of the control group regardless of the gingival index (G1) or the plaque index (PL 1).

Experimental example II, observation of the prevention and treatment effect of the toothpaste of the present invention on gingival atrophy

Gingival atrophy refers to recession and shrinkage of gingiva covering the surfaces of tooth roots and alveolar bones, so that part of the tooth roots are exposed, and is a common disease caused by various reasons, mainly manifested by enlarged slits, exposed tooth roots, sensitive teeth and the like. Besides affecting the beauty of teeth, the dental caries can cause repeated attacks of long-term chronic infection and inflammation of periodontal tissues. Not only the chewing function of the oral cavity is damaged, but also the whole body health is seriously influenced. Diagnosis of gingival atrophy, gingivitis with gingival tissue atrophy, alveolar bone resorption, exposed tooth root, and enlarged gap between teeth. The experiment observes that the toothpaste has the curative effect of preventing and treating the gingival atrophy.

Firstly, testing personnel:

120 patients with gingival atrophy were randomly divided into two groups, 60 cases each of the experimental group (toothpaste of example 4 of the present invention) and the control group (toothpaste of the ordinary gum-protecting series).

II, a test method:

the test group members brushed their teeth using the toothpaste of the present invention. The control group used common toothpaste, 3g of which was applied, the toothpaste was smeared on the gum with soft bristles, and after about 5 minutes of brushing the teeth and the slits between the teeth, the teeth were kept in the oral cavity for about 10 minutes, and rinsed with warm boiled water. Before and after breakfast, after lunch and after dinner every day, the treatment effect is checked and registered after february without eating snacks after brushing teeth.

Evaluation criteria for therapeutic effect of gingival atrophy: and (3) curing: the discomfort of local pain disappears, the tooth becomes loose and disappears, the tooth root is exposed and disappears, and the tooth gap becomes narrow. The effect is shown: gingival inflammation disappears, gingival atrophy, teeth are loose, and gingival exposure is improved. Improvement: the inflammation of the gum disappears, the gum atrophy is improved, and the teeth are still loose and the tooth root is still exposed. And (4) invalidation: gingival inflammation, tooth loosening, tooth root exposure and the like are not improved.

Thirdly, test results:

analysis of treatment effect on gingival atrophy: the treatment effect of the toothpaste of the invention and the treatment effect of the common toothpaste of the control group are statistically analyzed, and the effects are evaluated as follows:

TABLE II comparison of the treatment effects of the gingival atrophy cases of the experimental group and the control group

And (3) analyzing test results: the treatment effect of the test group and the control group is shown by statistical treatment: compared with a control group (common gum protecting series toothpaste), the experimental group (the toothpaste disclosed by the invention) has a better curative effect on gingival atrophy than the common toothpaste.

Experimental example III, observation of the prevention and treatment effects of the toothpaste on canker sore

The oral ulcer is commonly called aphtha, is an ulcerative disease of oral mucosa which repeatedly attacks in the oral cavity, can occur on any part of the oral mucosa, and can occur on the labial side, the buccal side and the gum. Canker sores can develop recurrent attacks. Canker sores are caused by a variety of factors, such as dyspepsia, deficiency of trace elements, mental stress, or trauma to residual roots in the mouth. Because the cause of the oral ulcer is not clear, the oral ulcer can not be cured radically at present. The treatment principle is to eliminate the cause of disease, strengthen the physique and treat the disease symptomatically, so as to reduce the recurrence frequency, prolong the intermittence period of the disease, relieve the pain and promote the healing.

Firstly, testing personnel:

60 patients with oral ulcers were randomized into treatment and control groups of 30 patients each.

II, a test method:

the efficacy of the test group (toothpaste of the invention in example 4) and the control group (toothpaste of the general gum-protecting series) on the treatment of oral ulcer was analyzed. The oral ulcer is diagnosed according to the diagnosis standard of oral ulcer in 'oral mucosa diseases and the like'.

Test groups: the toothpaste is smeared on the ulcer surface of a patient suffering from dental ulcer; control group: the common toothpaste is smeared on the ulcer surface of a patient suffering from dental ulcer. The toothpaste is applied for 1 time before and after breakfast, after lunch and after dinner, and is rinsed with warm boiled water after applying toothpaste for 30 minutes each time, and the diagnosis and treatment effects are reviewed and recorded after 10 days.

Evaluation standard of treatment effect of oral ulcer: and (3) curing: the local pain symptom disappears, and the ulcer surface disappears; the effect is shown: local pain symptoms basically disappear, and the ulcer surface is obviously reduced or the number of ulcers is reduced; the method has the following advantages: local pain symptoms are relieved, and the ulcer surface and the number are reduced; and (4) invalidation: the symptoms of local pain are not reduced, the ulcer surface is not obviously reduced, the number of ulcers is not reduced, the symptoms are not reduced after the treatment for 4 days by the method, and patients abandon the method and become invalid patients.

Thirdly, test results:

analysis of treatment effect of oral ulcer: the treatment effect of the toothpaste of the invention and the treatment effect of the common toothpaste of the control group are reviewed for 10 days and observed for statistical analysis, and the effect is evaluated.

TABLE III comparison of the efficacy of the test and control groups

And (3) analyzing test results: the treatment effect of the test group and the control group is shown by statistical treatment: the comparison and analysis of the curative effect of the experimental group (the toothpaste of the invention) and the control group (the common toothpaste) on treating the dental ulcer have obvious difference (P <0.01), which shows that the effect of the toothpaste of the invention on treating the dental ulcer is obviously better than that of the common toothpaste of the control group.

Fourth experimental example, observation of prevention and treatment effects of the toothpaste of the present invention on upper respiratory tract inflammation and respiratory tract infectious disease

Respiratory infectious diseases are diseases with respiratory symptoms as main parts, and are mainly caused by pathogens such as viruses, bacteria, chlamydia, mycoplasma and the like. Common respiratory infectious diseases, influenza. The toothpaste of the invention has certain inhibiting and killing effects on viruses and bacteria. Therefore, the experiment verifies and researches the prevention effect of the toothpaste on the respiratory inflammation and the upper respiratory tract infectious diseases.

Firstly, testing personnel:

the first two students in a school are selected to have 4 classes and 200 students in men and women, the 200 students are randomly divided into two groups, namely a test group and a control group, each student in the test group sends one toothpaste according to the embodiment 4 of the invention, and each student in the control group sends one common toothpaste.

II, a test method:

after the toothpaste was dispensed, 4 senior five-sense-department doctors began to perform unified list registration diagnosis of the nose, throat and throat examination and clinical symptoms of 200 classmates at the same time. Among 200 classmates, 81 persons with upper respiratory inflammation were examined with an incidence of 40.5%, of which 41 persons in the test group and 40 persons in the control group.

Each student uses the toothbrush and toothpaste to brush the teeth: the students are ordered to brush teeth with the toothpaste of the invention and the common toothpaste which are distributed daily, the teeth are brushed once in the morning and at night, 3g of toothpaste is used each time, and the toothpaste is brushed for 5 minutes with moderate force.

Thirdly, test results:

3.1 Observation of therapeutic Effect on respiratory tract inflammation

After 30 days, the same 4 doctors in the department of five sense organs performed nose, nasopharynx, pharynx and laryngopharynx examinations on the former examined classmates with airway inflammation and asked about upper airway symptoms and list registration.

Experimental results comparative analysis: the changes of upper respiratory tract and symptoms observed after 30 days in the test group and the control group are compared and analyzed, and the summary comparison is carried out.

TABLE IV comparison of the effects of test and control groups on upper airway inflammation

The results in the table show that the curative effect of the test group and the control group is statistically analyzed, and the effect of the test group is obviously better than that of the control group. The research proves that the toothpaste has good effect on the upper respiratory tract inflammation.

3.2 Observation of prophylactic Effect against respiratory infectious diseases

The statistical comparison analysis is carried out on the number of the upper respiratory tract inflammation and the respiratory tract infectious diseases which are newly generated within 6 months in the study of the experimental group and the control group.

TABLE V comparison of the effect of the test group and the control group in preventing respiratory diseases

The data of preventing upper respiratory inflammation and upper respiratory infectious diseases of the test group and the control group in the table are statistically processed, and the toothpaste of the invention is found to be better than the common toothpaste in preventing the upper respiratory infection and the upper respiratory infectious diseases.

Fifth Experimental example, observation of the effect of the toothpaste of the present invention on enamel and dentin

The cleaning effect of the toothpaste on teeth is mostly realized by an abrasive, and the abrasive in the toothpaste is a main factor for mechanically removing dental plaque and stain in the process of brushing teeth. The ability of the abrasive to remove plaque and tooth stains is related to the amount of abrasive added to the toothpaste formulation, the hardness, particle size, shape, etc. of the abrasive. If toothpaste with too high a friction force is used, the hard tissues of the teeth can be abraded while the teeth are cleaned. Abrasives have been found to be less damaging to enamel, while abrasion occurs primarily in dentin. This is primarily due to the higher hardness of enamel, which is lower than or close to the mohs hardness of the abrasives in toothpaste formulations. Thus, when considering the wear of toothpaste on the hard tissues of teeth, much attention is paid to the wear of dentin.

Thus, this experiment investigated the relative wear of dentin and the relative wear of enamel for the toothpastes of examples 1-5 and three general toothpastes commercially available, each group using 3 enamel and dentin specimens, respectively, and the average wear was counted, with the results as given in the following table:

table VI relative abrasion values for enamel and dentin for the toothpastes of examples 1-5

As can be seen from the table, the toothpaste of the invention adopts the rice hull ash nano micro powder and the calcium carbonate as the abrasive, thereby effectively removing dental plaque without damaging enamel and dentin, being mild and clean, protecting teeth and protecting gum. In the experimental process, the toothpaste disclosed by the invention is lower in tooth abrasion, and has very little abrasion to enamel and dentin, and can be ignored, compared with the common commercial toothpaste. Therefore, the toothpaste of the invention has better effects of removing dental plaque, cleaning and polishing teeth than the common toothpaste, but does not excessively abrade enamel. The reason is that the effective components can better act on the teeth by the friction between the toothbrush and the teeth in the process of tooth brushing due to the adoption of the nano-scale rice hull ash micropowder, thereby improving the tooth brushing effect. The nano-grade micro-powder has better adsorption property after water absorption and expansion than common friction agents, can effectively remove stains, has softer texture and cannot damage tooth glaze. In a word, the toothpaste has the advantages of good safety, high effectiveness, multiple effects and low cost, and is an original multiple-effect toothpaste.

Claims

1. The multi-effect toothpaste is characterized in that the effective components of the toothpaste comprise an aromatic traditional Chinese medicine composition and active polypeptide liquid; the fragrant traditional Chinese medicine composition is prepared from mint, agastache rugosus, rosemary and thyme according to a weight ratio of 2.4-3: 2.3-2.8: 2-2.6; the aromatic traditional Chinese medicine composition accounts for 5-25% of the total weight of the toothpaste; the active polypeptide liquid is prepared from acetyl hexapeptide, carnosine and oligopeptide 32 according to the weight ratio of 1: 1; the active polypeptide liquid accounts for 5-30% of the total weight of the toothpaste.

2. The multi-effect toothpaste as claimed in claim 1, wherein the aromatic Chinese medicinal composition is: the herba Menthae, herba Agastaches, herba Rosmarini officinalis and herba Thymi vulgaris in a weight ratio of 2.6:2.5: 2.4.

3. The multi-effect toothpaste of claim 1, wherein the aromatic traditional Chinese medicine composition accounts for 15-20% of the total weight of the toothpaste; the active polypeptide liquid accounts for 8-15% of the total weight of the toothpaste.

4. The multi-effect toothpaste according to claim 1 further comprising abrasives, humectants, thickeners, foaming agents, preservatives, sweeteners and other additives.

5. The multi-effect toothpaste as claimed in claim 1, wherein the multi-effect toothpaste comprises the following components by weight percent: 5 to 25 percent of aromatic traditional Chinese medicine composition, 5 to 30 percent of active polypeptide liquid, 20 to 50 percent of abrasive, 10 to 40 percent of humectant, 0.5 to 2 percent of thickening agent, 1 to 5 percent of foaming agent, 0.1 to 0.4 percent of preservative, 0 to 0.3 percent of sweetening agent, 0 to 5 percent of other additives and the balance of water.

6. The multiple-effect toothpaste according to claim 5, wherein the multiple-effect toothpaste comprises, by weight, 21% of the aromatic traditional Chinese medicine composition, 9% of the active polypeptide solution, 26% of the abrasive, 30% of the humectant, 1.5% of the thickener, 3% of the foaming agent, 0.4% of the preservative, 2.3% of other additives, and the balance of water.

7. The toothpaste with multiple efficacies as claimed in claim 5 or 6, wherein the abrasive is prepared from rice hull ash nano micropowder and calcium carbonate according to the weight ratio of 1-4: 1 are mixed.

8. The multi-effect toothpaste as claimed in claim 7, wherein the abrasive is prepared from rice husk ash nanopowder and calcium carbonate in a weight ratio of 2:1 are mixed.

9. A preparation method of a multi-effect toothpaste is characterized in that superfine powder of an aromatic traditional Chinese medicine composition, active polypeptide liquid, a humectant and a preservative are mixed and put into deionized water to be stirred to prepare a deionized water solution, then a thickening agent, a friction agent, a foaming agent and other additives are added to be mixed, the mixture is sent into a three-in-one vacuum paste making machine to be stirred and milled at a high speed for 25-40 minutes, vacuum degassing is carried out, then all other materials are added, and then the mixture is stirred and milled for 10-25 minutes to be mixed uniformly to obtain a toothpaste body.

10. The method for preparing a multifunctional toothpaste according to claim 9 wherein the abrasive is prepared by washing rice hulls, air drying or oven drying, burning in a furnace for whitening, decarburizing, burning to obtain white rice hull ash, micronizing to obtain rice ash nanopowder, and mixing with calcium carbonate at a weight ratio.