CN106974866A - A kind of folium artemisiae argyi formula toothpaste and preparation method thereof - Google Patents
A kind of folium artemisiae argyi formula toothpaste and preparation method thereof Download PDFInfo
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- CN106974866A CN106974866A CN201710233460.2A CN201710233460A CN106974866A CN 106974866 A CN106974866 A CN 106974866A CN 201710233460 A CN201710233460 A CN 201710233460A CN 106974866 A CN106974866 A CN 106974866A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The invention discloses a kind of folium artemisiae argyi formula toothpaste and preparation method thereof, belong to commodity technical field.Folium artemisiae argyi formula toothpaste includes Chinese medical extract, in terms of mass fraction, the Chinese medical extract includes 0.057~0.143 part of Folium Artemisiae Argyi extract, 0.043~0.107 part of isatis root extract, 0.03~0.07 part of mint extract, 0.014~0.036 part of Notogineng Extract, 0.014~0.036 part of bletilla striata extract, 0.014~0.036 part of Cortex Lycii extract, 0.014~0.036 part of pepperweed seed extract, 0.014~0.036 part of Magnolia cortex P.E.Folium artemisiae argyi formula toothpaste making process flow of the present invention is simple, easily operate, cost is low, be particularly suitable for use in factorial praluction；And each medicinal herb componentses are by cooperating and promoting in folium artemisiae argyi formula toothpaste of the present invention, complementation between taking into account, drug effect complements each other, a variety of oral problems can be solved simultaneously, reach antiallergic sense, hemostasis, whitening, anti-inflammatory, sterilization, the effect removed the pre- anti-caries of bacterial plaque, remove oral peculiar smell.
Description
Technical field
The present invention relates to commodity technical field, a kind of folium artemisiae argyi formula toothpaste and preparation method thereof is particularly related to.
Background technology
Dental care product is cleaning indispensable in people's daily life and health treatment, and this class product category is numerous
It is many, it is mainly used in keeping oral cavity and cleaning of teeth, promotes breath freshening, nurse gum, safeguard oral cavity good environment etc.；Toothpaste is
The cleaning supplies commonly used in daily life, there is very long history.In recent years, due to the continuous enhancing of consumer healthcare's consciousness,
Pursue the requirement of natural safety；And with the continuous development of scientific technology, technological equipment is updated and perfect, various
The toothpaste of type is come out one after another, and the quality and class of product are improved constantly, present toothpaste variety by single clean type toothpaste,
Develop into the Mobyneb toothpaste of great variety of goods, vdiverse in function, up to a hundred brands, meet the need of the different levels level of consumption
Ask.Because Chinese medicinal plant active component has the advantages that natural, safe, therefore in the market is turned into using the feature of active ingredient of Chinese herbs
The emphasis of Developing.
Existing Chinese medicine toothpaste mostly using adding single traditional Chinese medicine ingredients, on a variety of Chinese medicine composition simultaneously applied to toothpaste with
The toothpaste for solving a variety of oral problems is not studied, therefore, is needed badly to being studied using the toothpaste of a variety of Chinese medicine composition.
The content of the invention
In view of this, it is an object of the invention to propose a kind of folium artemisiae argyi formula toothpaste and preparation method thereof, folium artemisiae argyi formula
Plurality of Chinese extract is added in toothpaste, can be reached while solving effect of a variety of oral problems；And the folium artemisiae argyi is formulated tooth
Ointment preparation is simple, easily operation, and be particularly suitable for use in factorial praluction.
Toothpaste is formulated based on a kind of folium artemisiae argyi that the above-mentioned purpose present invention is provided, the folium artemisiae argyi formula toothpaste includes traditional Chinese medicine extraction
Thing, in terms of mass fraction, the Chinese medical extract includes 0.057~0.143 part of Folium Artemisiae Argyi extract, isatis root extract 0.043
~0.107 part, 0.03~0.07 part of mint extract, 0.014~0.036 part of Notogineng Extract, bletilla striata extract 0.014~
0.036 part, 0.014~0.036 part of Cortex Lycii extract, 0.014~0.036 part of pepperweed seed extract, Magnolia cortex P.E 0.014
~0.036 part.
Preferably, folium artemisiae argyi formula toothpaste also includes auxiliary material, in terms of mass fraction, the auxiliary material include NMF 40~
50 parts, 1.1~1.4 parts of thickener, 15~25 parts of rubbing agent, 1.5~2.5 parts of foaming agent, 0.8~1.0 part of bacteriostatic agent, sweetener
0.2~0.3 part, 1.0~1.4 parts of essence.
It is highly preferred that the NMF is sorbierite and polyethylene glycol 400, the matter of the sorbierite and polyethylene glycol 400
Amount is than being (40~50):(0.2~1).
It is highly preferred that the thickener is sodium carboxymethylcellulose, hydroxyethyl cellulose and guar gum, the carboxymethyl is fine
The mass ratio of the plain sodium of dimension, hydroxyethyl cellulose and guar gum is (0.3~0.4):(0.4~0.5):(0.4~0.5).
It is highly preferred that the rubbing agent is one kind in silica or calcium carbonate.
It is highly preferred that the foaming agent is one kind in sldium lauryl sulfate or sodium lauroyl sarcosine.
It is highly preferred that the bacteriostatic agent is sodium copper chlorophyllin.
It is highly preferred that the sweetener is one kind in sucrose, xylitol or honey element.
Based on identical inventive concept, present invention also offers the preparation method that a kind of folium artemisiae argyi is formulated toothpaste, including it is as follows
Step：
(1) in terms of mass fraction, weigh Chinese medical extract in folium artemisiae argyi as claimed in claim 2 formula formulation of tooth-paste and
Auxiliary material, the Chinese medical extract is well mixed；
(2) by foaming agent, sweetener, bacteriostatic agent it is soluble in water mixed solution；
(3) NMF, thickener, rubbing agent and essence are added in mixed solution obtained by step (2), is evenly stirred until increasing
Thick dose is completely dispersed to obtain auxiliary material solution；
(4) Chinese medical extract in step (1) is added in the auxiliary material solution of step (3), mixing is produced.
Effect of each traditional Chinese medicine ingredients is as follows in folium artemisiae argyi formula toothpaste of the present invention：
Folium artemisiae argyi：It is China's traditional Chinese medicine for the perennial wild herb of composite family artemisia, successive dynasties medicine writings are recorded " for hemostasis
Key medicine ", is one of gynaecology's common medicine；Have sedation to nervous system, and with eliminating cold to stop pain, control outside pruitus, antibacterial,
Anticancer, cholagogic, eliminating the phlegm, hemostasis and anti-freezing, antianaphylactic effect.
Radix Isatidis：Fall the dry algae root of orchid, bitter, cold in nature, enter liver stomach two for acanthaceous plant kalimeris or crucifer
Through；Clearing heat and detoxicating, the clearing throat of energy, can control acute fever, abscess of throat, aphtha etc.；Have an antibacterial resistant effect, antimicrobial spectrum compared with
Extensively, there is antibacterial action to a variety of Gram-negatives and positive bacteria, it is good to a variety of viral infection curative effects.
Peppermint：Popular name, " lunar caustic grass ", is a kind of conventional Chinese medicine, is swollen and ache available for treatment influenza, gum
Disease；Peppermint contains certain alkenes, can reach lung via blood circulation so that breathing breath freshening；Meanwhile, peppermint can also delay
Solve various gums uncomfortable, reduce bacteria breed.
Pseudo-ginseng：For Araliaceae, first recorded in《Compendium of Materia Medica》, Li Shizhen (1518-1593 A.D.) says that " that person says left three right sides four of its leaf, therefore named three
Seven ... say it is near it, invaluable, valuable title "；The effect of pseudo-ginseng has dissipate stasis of blood hemostasis, detumescence ding-tong, it is extensive in recent years
In terms of applied to the Coryza Treated by Syndrome Differentiation of inside and outside section's disease, especially oral health nursing, with positive effect；Add pseudo-ginseng activity
The toothpaste of extract can aid in promotion mucous membrane of mouth microcirculation, improve gingivitis cardinal symptom.
The bletilla striata：Bitter, sweet and puckery, cold nature, enter lung channel；Function with hemostasis, detumescence, can treat raw sore bleeding, carbuncle
Subcutaneous ulcer pyogenic infections, ulcer, rhagadia manus et pedis；《Weinan book on Chinese herbal medicine》It is called " to control pain and hinder lung qi, tonifying lung is empty, and cough-relieving is coughed, and disappear lung rash hemoptysis, convergence
Lung qi ".
The root bark of Chinese wolf-berry：For clear bone heat, the cool blood key medicine of strict generation book on Chinese herbal medicine；It is sweet in flavor and cold in property, return lung, liver and kidney channel；Cool blood, reducing the asthenic fever,
Purte the white；Suitable for deficiency of Yin hectic fever, night sweat, hectic fever due to yin, cough with lung heat, blood-heat bleeding goes out blood trouble；Its decoction liquor is added into toothpaste
In medicated toothpaste is made is to employ being used in conjunction with method and organically combining for medicine and toothpaste, can thus brush teeth
During produce due drug effect, reach day for preventing and treating odontopathy.
Lepidium seed：It is pungent, it is bitter, it is cold in nature；Drink, inducing diuresis for removing edema are exempted from purging the lung of pathogenic fire；Inflammatory can be suppressed to ooze out, energy similar to semen brassicae
Suppress capillary permeability, suppress inflammatory and ooze out, ooze out serous coat, synovial membrane, the inflammatory of alveolar parietal vessel and reduce and make to ooze out
Liquid reabsorption.
The bark of official magnolia：Pungent, hardship, it is warm-natured；There are eliminating dampness, promoting the circulation of qi, dissolving phlegm, except mite, can suppress to cause the bacterium of ulcer,
And the pre- anti-caries of bacterial plaque can be removed, oral peculiar smell is eliminated.
The addition of sodium copper chlorophyllin can be sterilized, deodorization anti-inflammation hemostasia, play synergy, and can cover ground bone
Skin decocts the pigment brought into of agent, thus avoid by the degassing of Chinese medicine root bark of Chinese wolf-berry decoction liquor cause effective ingredient loss and
Reduce drug effect.
From the above it can be seen that the advantages of the present invention are：
(1) each medicinal herb componentses are by cooperating and promoting in the folium artemisiae argyi formula toothpaste of the present invention, between taking into account
Complementation, drug effect complemented each other, and a variety of oral problems can be solved simultaneously, is reached antiallergic sense, hemostasis, whitening, anti-inflammatory, is killed
Bacterium, the effect removed the pre- anti-caries of bacterial plaque, remove oral peculiar smell.
(2) folium artemisiae argyi formula toothpaste making process flows of the present invention are simple, easily operate, cost is low, be particularly suitable for use in factory
Metaplasia is produced.
Embodiment
For the object, technical solutions and advantages of the present invention are more clearly understood, below in conjunction with specific embodiment, to this hair
It is bright to be further described.
First, embodiment is prepared
Embodiment 1
A kind of folium artemisiae argyi is formulated toothpaste, including Chinese medical extract and auxiliary material, and in terms of mass fraction, the Chinese medical extract includes
0.057 part of Folium Artemisiae Argyi extract, 0.107 part of isatis root extract, 0.03 part of mint extract, 0.036 part of Notogineng Extract, the bletilla striata
0.014 part of extract .036 parts of Cortex Lycii extract, 0.036 part of pepperweed seed extract, 0.014 part of Magnolia cortex P.E；With quality
Number meter, the auxiliary material include 40 parts of NMF, 1.1 parts of thickener, 15 parts of rubbing agent, 2.5 parts of foaming agent, 1.0 parts of bacteriostatic agent,
0.3 part of sweetener, 1.4 parts of essence；
The NMF is that mass ratio is 40:1 sorbierite and polyethylene glycol 400, the thickener is that mass ratio is
0.3:0.4:0.5 sodium cellulose glycolate, hydroxyethyl cellulose and guar gum, the rubbing agent is silica；Described
Infusion is sldium lauryl sulfate, and the bacteriostatic agent is sodium copper chlorophyllin, and the sweetener is sucrose；
Its preparation method comprises the following steps：
(1) weighs the Chinese medical extract and auxiliary material in the folium artemisiae argyi formula formulation of tooth-paste in terms of mass fraction, will be described
Chinese medical extract is well mixed；
(2) foaming agent, sweetener, bacteriostatic agent are dissolved in deionized water by obtains mixed solution；；
(3) adds NMF, thickener, rubbing agent and essence in mixed solution obtained by step (2), is evenly stirred until
Thickener is completely dispersed to obtain auxiliary material solution；
(4) adds the Chinese medical extract in step (1) in the auxiliary material solution of step (3), and mixing is produced.
Embodiment 2
A kind of folium artemisiae argyi is formulated toothpaste, including Chinese medical extract and auxiliary material, and in terms of mass fraction, the Chinese medical extract includes
0.143 part of Folium Artemisiae Argyi extract, 0.043 part of isatis root extract, 0.07 part of mint extract, 0.014 part of Notogineng Extract, the bletilla striata
0.036 part of extract, 0.014 part of Cortex Lycii extract, 0.014 part of pepperweed seed extract, 0.036 part of Magnolia cortex P.E；With matter
Number meter is measured, the auxiliary material includes 50 parts of NMF, 1.4 parts of thickener, 25 parts of rubbing agent, 1.5 parts of foaming agent, bacteriostatic agent 0.8
Part, 0.2 part of sweetener, 1.0 parts of essence；
The NMF is that mass ratio is 50:0.2 sorbierite and polyethylene glycol 400, the thickener is that mass ratio is
0.4:0.5:0.4 sodium cellulose glycolate, hydroxyethyl cellulose and guar gum, the rubbing agent is calcium carbonate；The foaming
Agent is sodium lauroyl sarcosine, and the bacteriostatic agent is sodium copper chlorophyllin, and the sweetener is xylitol；
Its preparation method comprises the following steps：
(1) weighs the Chinese medical extract and auxiliary material in the folium artemisiae argyi formula formulation of tooth-paste in terms of mass fraction, will be described
Chinese medical extract is well mixed；
(2) foaming agent, sweetener, bacteriostatic agent are dissolved in deionized water by obtains mixed solution；；
(3) adds NMF, thickener, rubbing agent and essence in mixed solution obtained by step (2), is evenly stirred until
Thickener is completely dispersed to obtain auxiliary material solution；
(4) adds the Chinese medical extract in step (1) in the auxiliary material solution of step (3), and mixing is produced.
Embodiment 3
A kind of folium artemisiae argyi is formulated toothpaste, including Chinese medical extract and auxiliary material, and in terms of mass fraction, the Chinese medical extract includes
0.1 part of Folium Artemisiae Argyi extract, 0.075 part of isatis root extract, 0.05 part of mint extract, 0.025 part of Notogineng Extract, the bletilla striata carry
Take 0.025 part of thing, 0.025 part of Cortex Lycii extract, 0.025 part of pepperweed seed extract, 0.025 part of Magnolia cortex P.E；With quality
Number meter, the auxiliary material include 43 parts of NMF, 1.2 parts of thickener, 18 parts of rubbing agent, 1.8 parts of foaming agent, 0.9 part of bacteriostatic agent,
0.2 part of sweetener, 1.3 parts of essence；
The NMF is that mass ratio is 43:0.8 sorbierite and polyethylene glycol 400, the thickener is that mass ratio is
0.3:0.5:0.5 sodium cellulose glycolate, hydroxyethyl cellulose and guar gum, the rubbing agent is calcium carbonate；The foaming
Agent is sodium lauroyl sarcosine, and the bacteriostatic agent is sodium copper chlorophyllin, and the sweetener is honey element；
Its preparation method comprises the following steps：
(1) weighs the Chinese medical extract and auxiliary material in the folium artemisiae argyi formula formulation of tooth-paste in terms of mass fraction, will be described
Chinese medical extract is well mixed；
(2) foaming agent, sweetener, bacteriostatic agent are dissolved in deionized water by obtains mixed solution；；
(3) adds NMF, thickener, rubbing agent and essence in mixed solution obtained by step (2), is evenly stirred until
Thickener is completely dispersed to obtain auxiliary material solution；
(4) adds the Chinese medical extract in step (1) in the auxiliary material solution of step (3), and mixing is produced.
Embodiment 4
A kind of folium artemisiae argyi is formulated toothpaste, including Chinese medical extract and auxiliary material, and in terms of mass fraction, the Chinese medical extract includes
0.079 part of Folium Artemisiae Argyi extract, 0.09 part of isatis root extract, 0.04 part of mint extract, 0.032 part of Notogineng Extract, the bletilla striata
0.019 part of extract, 0.03 part of Cortex Lycii extract, 0.031 part of pepperweed seed extract, 0.021 part of Magnolia cortex P.E；With quality
Number meter, the auxiliary material include 48 parts of NMF, 1.3 parts of thickener, 23 parts of rubbing agent, 2.3 parts of foaming agent, 0.8 part of bacteriostatic agent,
0.25 part of sweetener, 1.1 parts of essence；
The NMF is that mass ratio is 48:0.4 sorbierite and polyethylene glycol 400, the thickener is that mass ratio is
0.4:0.4:0.5 sodium cellulose glycolate, hydroxyethyl cellulose and guar gum, the rubbing agent is silica；Described
Infusion is sldium lauryl sulfate, and the bacteriostatic agent is sodium copper chlorophyllin, and the sweetener is sucrose；
Its preparation method comprises the following steps：
(1) weighs the Chinese medical extract and auxiliary material in the folium artemisiae argyi formula formulation of tooth-paste in terms of mass fraction, will be described
Chinese medical extract is well mixed；
(2) foaming agent, sweetener, bacteriostatic agent are dissolved in deionized water by obtains mixed solution；；
(3) adds NMF, thickener, rubbing agent and essence in mixed solution obtained by step (2), is evenly stirred until
Thickener is completely dispersed to obtain auxiliary material solution；
(4) adds the Chinese medical extract in step (1) in the auxiliary material solution of step (3), and mixing is produced.
Embodiment 5
A kind of folium artemisiae argyi is formulated toothpaste, including Chinese medical extract and auxiliary material, and in terms of mass fraction, the Chinese medical extract includes
It is 0.123 part of Folium Artemisiae Argyi extract, 0.057 part of isatis root extract, 0.059 part of mint extract, 0.018 part of Notogineng Extract, white
0.031 part of splendid achnatherum extract, 0.022 part of Cortex Lycii extract, 0.021 part of pepperweed seed extract, 0.030 part of Magnolia cortex P.E；With
Mass fraction meter, the auxiliary material includes 45 parts of NMF, 1.2 parts of thickener, 20 parts of rubbing agent, 2.0 parts of foaming agent, bacteriostatic agent
0.9 part, 0.3 part of sweetener, 1.2 parts of essence；
The NMF is that mass ratio is 45:0.6 sorbierite and polyethylene glycol 400, the thickener is that mass ratio is
0.35:0.45:0.45 sodium cellulose glycolate, hydroxyethyl cellulose and guar gum, the rubbing agent is calcium carbonate；Described
Infusion is sldium lauryl sulfate, and the bacteriostatic agent is sodium copper chlorophyllin, and the sweetener is honey element；
Its preparation method comprises the following steps：
(1) weighs the Chinese medical extract and auxiliary material in the folium artemisiae argyi formula formulation of tooth-paste in terms of mass fraction, will be described
Chinese medical extract is well mixed；
(2) foaming agent, sweetener, bacteriostatic agent are dissolved in deionized water by obtains mixed solution；；
(3) adds NMF, thickener, rubbing agent and essence in mixed solution obtained by step (2), is evenly stirred until
Thickener is completely dispersed to obtain auxiliary material solution；
(4) adds the Chinese medical extract in step (1) in the auxiliary material solution of step (3), and mixing is produced.
Test example 1
Folium artemisiae argyi is formulated the stability test of toothpaste
The folium artemisiae argyi prepared using embodiment 1~5 is formulated in toothpaste, the baking oven for being respectively placed in 50 DEG C, is seen every 10 days
Examine a toothpaste and whether there is fuel-displaced water outlet phenomenon, outward appearance and color whether to change, under toothpaste smell and normal temperature smell whether
Unanimously.Observation 3 months is simultaneously recorded.
As a result：The toothpaste of embodiment 1~5 is without fuel-displaced water outlet phenomenon, and outward appearance does not change substantially with color, toothpaste gas
Taste with it is basically identical under normal temperature；Illustrate that the folium artemisiae argyi formula toothpaste of the present invention is basically identical with properties under normal temperature at high temperature,
It is overall that there is good stability.
Test example 2
Folium artemisiae argyi is formulated the skin irritation test of toothpaste
From 100 health volunteers, each 50 of men and women, the age between 15 to 65 years old, with reference to the acute skins of GB7919-87
The folium artemisiae argyi formula toothpaste that skin Irritation Test Method is prepared to the embodiment of the present invention 1~5 is detected, according to by GB7919-87 skins
Skin stimulates evaluation criterion, and folium artemisiae argyi formula toothpaste prepared by 1-5 of the embodiment of the present invention is nonirritant.
Test example 3
From 50 health volunteers, using 0~10 lineal scale by a series of attributes in embodiment 1~5
Various toothpaste are evaluated, as shown in table 1 to the average result experienced in the use of toothpaste：
Table 1.
As shown in Table 1, folium artemisiae argyi formula toothpaste viscosity of the present invention is moderate, and sand type appropriateness, foam quality and quantity are suitable,
Cleannes are higher, and Consumer's Experience is good.
Test example 4
The folium artemisiae argyi formula anti-sensitive property of toothpaste crosses detection
From 50 health volunteers, using 0~10 lineal scale by a series of attributes to being made in embodiment 1~5
Standby folium artemisiae argyi formula toothpaste carries out antiallergic performance evaluation, and specific method is：Prepare the molten of the vinegar that mixes in equal volume of 30ml and syrup
Liquid, and 50 DEG C of warm water；Subject cleans oral cavity, and above-mentioned solution is contained in 30 seconds in the mouth, then spued；Subject uses implementation
One kind in example 1~5 in toothpaste is clear after scrubbing 3 minutes；Subject drinks warm water, experiences the pain of tooth to evaluate toothpaste
Antiallergic performance；Aforesaid operations are repeated with the formula toothpaste of other in test example 1~5, the test interval is more than 1 hour；
Test result is as shown in table 2：
Table 2.
As shown in Table 2, folium artemisiae argyi formula toothpaste of the present invention has good anti-sensitive property.
Test example 5
Folium artemisiae argyi formula toothpaste anti-microbial property detection
With commercially available Colgate-Palmolive toothpaste as a control group, the folium artemisiae argyi formula toothpaste and control group tooth that prepared by detection embodiment 1~5
The anti-microbial property of cream, testing result is as shown in table 3：
| Strain | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Control group |
| Typhoid bacillus | 99.5% | 99.6% | 99.3% | 99.5% | 99.2% | 77.8% |
| Escherichia coli | 99.9% | 99.3% | 99.8% | 99.5% | 99.6% | 73.9% |
| Diplococcus pneumopniae | 99.1% | 99.3% | 99.2% | 99.6% | 99.5% | 74.6% |
| Staphylococcus | 99.8% | 99.6% | 99.3% | 99.7% | 99.5% | 72.6% |
Table 3.
As shown in Table 3, folium artemisiae argyi formula toothpaste of the present invention has good anti-microbial property.
Test example 6
The hemostasis of folium artemisiae argyi formula toothpaste, anti-inflammatory performance detection
Choose the patient 180 with bleeding gums or gingivitis, 15~60 years old age, no systemic disease, blood routine, blood
Platelet, clotting time and bleeding time are normal；In identical environment, it is divided into six groups, every group of 30 people, five groups of patients use system in embodiment 1~5
Standby folium artemisiae argyi formula toothpaste is experimental group, and one group of patient is that control group toothpaste uses commercially available Colgate-Palmolive toothpaste, and every group is brushed teeth sooner or later
Twice, using effect is observed after 3 minutes, 7 days every time；Using effect is as shown in table 4：
| Group class | Sum | It is not relieved number | It is relieved number | Recovery from illness number |
| Embodiment 1 | 30 | 0 | 14 | 16 |
| Embodiment 2 | 30 | 2 | 16 | 12 |
| Embodiment 3 | 30 | 0 | 18 | 12 |
| Embodiment 4 | 30 | 2 | 16 | 12 |
| Embodiment 5 | 30 | 0 | 16 | 14 |
| Control group | 30 | 24 | 6 | 0 |
Table 4.
As shown in Table 4, folium artemisiae argyi formula toothpaste of the present invention has good anti-inflammatory, haemostatic effect, to bleeding gums and gum
Inflammation has significant therapeutic effect.
Test example 7
Folium artemisiae argyi is formulated the whitening effect of toothpaste
The tooth for taking 6 jaundice to black is tested, respectively numbering 1,2,3,4,5,6, wherein 1~No. 5 tooth is right respectively
The folium artemisiae argyi prepared in embodiment 1~5 should be used to be formulated toothpaste processing, No. 6 teeth are commercially available Colgate-Palmolive toothpaste using control toothpaste
Processing.Six identical toothbrushes are taken, according to the amount of paste and normal brush dynamics normally brushed teeth, corresponding tooth is scrubbed respectively
Tooth, brush was to 3 to 5 minutes every time, progress 15 times altogether.The pollution index of the tooth of before processing is 100, the tooth after processing
Pollution index is as shown in table 5：
| Numbering teeth | Toothpaste used | Use rear pollution index |
| 1 | Embodiment 1 | 10 |
| 2 | Embodiment 2 | 7 |
| 3 | Embodiment 3 | 9 |
| 4 | Embodiment 4 | 5 |
| 5 | Embodiment 5 | 6 |
| 6 | Control group | 50 |
Table 5.
As shown in Table 5, folium artemisiae argyi formula toothpaste of the present invention has good whitening effect.
Test example 8
Folium artemisiae argyi formula toothpaste removes the detection of oral peculiar smell
(1) subject and packet
Oral cavity was not used in 18~60 years old subject with serious halitosis symptom 90,1 month in the selection age
Medicine or gargle, dental care was not received in 3 months；Subject is divided into six groups, five groups of subjects make as experimental group
The folium artemisiae argyi prepared with embodiment 1~5 is formulated toothpaste, and one group of subject is as a control group commercially available Colgate-Palmolive tooth using control toothpaste
Cream.
Five groups of experimental group subjects are brushed teeth 2 times using folium artemisiae argyi formula toothpaste daily, 3~5 minutes every time, control group subject
Daily using commercially available black younger sister's toothpaste brush teeth 2 this, 3~5 minutes every time, test 30 days, observe result.
(2) observation index
Halitosis be divided into without, it is light, in, again；Slight halitosis：Halitosis is felt, other people can't smell；Moderate halitosis：When speaking other people
Halitosis can be smelt；Severe halitosis：Other people can smell halitosis when silent.
Subject is examined in for 30 days using sample by same doctor, and is recorded, as a result as shown in table 6：
| Group class | Sum | Nothing | Gently | In | Weight |
| Embodiment 1 | 15 | 7 | 5 | 2 | 1 |
| Embodiment 2 | 15 | 8 | 4 | 2 | 1 |
| Embodiment 3 | 15 | 9 | 5 | 1 | 0 |
| Embodiment 4 | 15 | 9 | 3 | 1 | 2 |
| Embodiment 5 | 15 | 8 | 4 | 2 | 1 |
| Control group | 15 | 2 | 3 | 4 | 6 |
Table 6.
As shown in Table 6, folium artemisiae argyi formula toothpaste of the present invention can effectively understand oral peculiar smell.
Test example 9
Folium artemisiae argyi formula toothpaste removes dental plaque performance detection
(1) subject and packet
The selection age was not used mouth cavity medicine in 18~65 years old subject with bacterial plaque 120,1 month or contained
Gargarism, dental care was not received in 3 months；Subject is divided into six groups, five groups of subjects use embodiment 1 as experimental group
~5 folium artemisiae argyi formula toothpaste prepared, one group of subject is as a control group commercially available Colgate-Palmolive toothpaste using control toothpaste.
Five groups of experimental group subjects are brushed teeth 2 times using folium artemisiae argyi formula toothpaste daily, 3~5 minutes every time, control group subject
Daily using commercially available Colgate-Palmolive toothpaste brush teeth 2 this, 3~5 minutes every time, test 30 days, observe result.
(2) observation index
Plaque index (PLI) is by Quigley and Hein proposition in 1962, scoring 0~5.
Plaque index (PLI) scoring criteria：0=Yin Yuan areas are without bacterial plaque；The facing in 1=Yin Yuan areas has thin bacterial plaque, but regards
Examine invisible, if bacterial plaque can be scraped with the side of probe pinpoint；2=is in gum edge or the visible moderate bacterial plaque of proximal surface；In 3=gingival sulcus or
Yin Yuan areas and proximal surface have a large amount of soft dirts.
Subject is examined in for 30 days using sample by same doctor, and is recorded, as a result as shown in table 7：
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Control group |
| PLI | 0.51±0.31 | 0.52±0.41 | 0.58±0.39 | 0.56±0.32 | 0.49±0.24 | 1.57±0.98 |
Table 7.
As shown in Table 7, folium artemisiae argyi formula toothpaste of the present invention can effectively understand the pre- anti-caries of dental plaque, suppress the life of bacterial plaque
Into.
It is that can be seen that by above-described embodiment 1~5 and the result of test example 1~9：Folium artemisiae argyi of the present invention is formulated toothpaste making process
Flow is simple, easily operate, cost is low, be particularly suitable for use in factorial praluction；And in each in the folium artemisiae argyi formula toothpaste of the present invention
Herb ingredients are by cooperating and promoting, and the complementation between taking into account, drug effect complements each other, can solved simultaneously many
Oral problem is planted, antiallergic sense, hemostasis, whitening, anti-inflammatory, sterilization, the work(removed the pre- anti-caries of bacterial plaque, remove oral peculiar smell is reached
Effect.
Those of ordinary skills in the art should understand that：The discussion of any of the above embodiment is exemplary only, not
It is intended to imply that the scope of the present disclosure (including claim) is limited to these examples；Under the thinking of the present invention, above example
Or can also not be combined between the technical characteristic in be the same as Example, and there is the different aspect of the present invention as described above
Many other changes, in order to it is concise they provided not in details.Therefore, within the spirit and principles of the invention,
Any omission, modification, equivalent substitution, improvement for being made etc., should be included in the scope of the protection.
Claims (9)
1. a kind of folium artemisiae argyi is formulated toothpaste, it is characterised in that the folium artemisiae argyi formula toothpaste includes Chinese medical extract, with mass fraction
Meter, the Chinese medical extract includes 0.057~0.143 part of Folium Artemisiae Argyi extract, 0.043~0.107 part of isatis root extract, peppermint
0.03~0.07 part of extract, 0.014~0.036 part of Notogineng Extract, 0.014~0.036 part of bletilla striata extract, the root bark of Chinese wolf-berry are carried
Take 0.014~0.036 part of thing, 0.014~0.036 part of pepperweed seed extract, 0.014~0.036 part of Magnolia cortex P.E.
2. folium artemisiae argyi as claimed in claim 1 is formulated toothpaste, it is characterised in that the folium artemisiae argyi formula toothpaste also includes auxiliary material, with
Mass fraction meter, the auxiliary material includes 40~50 parts of NMF, 1.1~1.4 parts of thickener, 15~25 parts of rubbing agent, foaming agent
1.5~2.5 parts, 0.8~1.0 part of bacteriostatic agent, 0.2~0.3 part of sweetener, 1.0~1.4 parts of essence.
3. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the NMF is sorbierite and polyethylene glycol
400, the mass ratio of the sorbierite and polyethylene glycol 400 is (40~50):(0.2~1).
4. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the thickener is sodium carboxymethylcellulose, hydroxyl
Ethyl cellulose and guar gum, the mass ratio of the sodium carboxymethylcellulose, hydroxyethyl cellulose and guar gum for (0.3~
0.4):(0.4~0.5):(0.4~0.5).
5. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the rubbing agent is in silica or calcium carbonate
One kind.
6. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the foaming agent is sldium lauryl sulfate or bay
One kind in acylsarcosine sodium.
7. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the bacteriostatic agent is sodium copper chlorophyllin.
8. folium artemisiae argyi as claimed in claim 2 is formulated toothpaste, it is characterised in that the sweetener is sucrose, xylitol or sweetness
One kind in element.
9. a kind of folium artemisiae argyi as described in any one of claim 1~8 is formulated the preparation method of toothpaste, it is characterised in that including such as
Lower step：
(1) in terms of mass fraction, Chinese medical extract in folium artemisiae argyi as claimed in claim 2 formula formulation of tooth-paste is weighed and auxiliary
Material, the Chinese medical extract is well mixed；
(2) by foaming agent, sweetener, bacteriostatic agent it is soluble in water mixed solution；
(3) NMF, thickener, rubbing agent and essence are added in mixed solution obtained by step (2), is evenly stirred until thickener
It is completely dispersed to obtain auxiliary material solution；
(4) Chinese medical extract in step (1) is added in the auxiliary material solution of step (3), mixing is produced.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175730A (en) * | 2018-03-05 | 2018-06-19 | 弘美制药（中国）有限公司 | It is a kind of for the composition in oral cavity and its application and preparation method |
| CN108635256A (en) * | 2018-05-07 | 2018-10-12 | 合肥钢骨玻璃制品有限公司 | A kind of environment-friendly type toothpaste using glass base abrasive material |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876972A (en) * | 2012-12-23 | 2014-06-25 | 吕子玉 | Anti-allergic toothpaste containing traditional Chinese medicinal components |
| CN106177465A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract and preparation method thereof |
| CN106236649A (en) * | 2016-08-26 | 2016-12-21 | 李时珍医药集团有限公司 | A kind of Folium Artemisiae Argyi toothpaste |
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2017
- 2017-04-11 CN CN201710233460.2A patent/CN106974866A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876972A (en) * | 2012-12-23 | 2014-06-25 | 吕子玉 | Anti-allergic toothpaste containing traditional Chinese medicinal components |
| CN106177465A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract and preparation method thereof |
| CN106236649A (en) * | 2016-08-26 | 2016-12-21 | 李时珍医药集团有限公司 | A kind of Folium Artemisiae Argyi toothpaste |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175730A (en) * | 2018-03-05 | 2018-06-19 | 弘美制药（中国）有限公司 | It is a kind of for the composition in oral cavity and its application and preparation method |
| CN108635256A (en) * | 2018-05-07 | 2018-10-12 | 合肥钢骨玻璃制品有限公司 | A kind of environment-friendly type toothpaste using glass base abrasive material |
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