CN110302292A - A kind of fresh breath oral nursing liquid and preparation method and application method - Google Patents
A kind of fresh breath oral nursing liquid and preparation method and application method Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention discloses a kind of fresh breath oral nursing liquids, are made of raw material from the following weight: 65~95 parts of wormwood hydrosol, 45~75 parts of radix pseudostellariae, 30~60 parts of peppermint, 30~60 parts of jasmine, 25~55 parts of field pennycress, 25~55 parts of the shell of areca nut, 35~55 parts of wrinkled giant hyssop, 50~80 parts of eupatorium extracting solution.The application fresh breath oral nursing liquid has many advantages, such as easy to carry, removing oral peculiar smell, inhibition plaque, the complication such as multiple oral disease and its caused dyssomnia, stress, indigestion can also be treated simultaneously, the advantages that being not in gingival discoloration, flora imbalance, secondary infection after use, oral nursing liquid contains sterilization and bacteriostasis effect, it is capable of the generation of the mouth diseases such as good pre- anti-caries, ulcer, simultaneously can also clearing heat and detoxicating, swelling and pain relieving, for gingivitis, periodontitis tool have a better effect.
Description
Technical field
The invention belongs to Nurse technology of TCM field more particularly to a kind of fresh breath oral nursing liquid and preparation method and
Application method.
Background technique
Mouth disease is all due to oral cavity including periodontitis, periodontal abscess, bleeding gums, canker sore and halitosis
In a large amount of pathogenic bacteria caused by.Oral cavity pathogen be it is normal in bacterium in human mouth, in health status, various microorganisms are being planted
Certain physiology combination is constituted in class and quantity.When flora imbalance, certain stronger pathogenic bacteria can excessively multiply and cause disease.
Related the survey showed that, and up to 97% adult perplexs by different degrees of oral problem in recent years.Pass through system
Fixed suitable nursing care plan, chooses appropriate nursing solution, can be substantially reduced the generation of mouth disease.Crossing oral care can subtract
Few intraoral bacterium, effective bactericidal haemostatic eliminate halitosis, protect the health of one's mouth, thus prevent bacterium and toxin from invading blood,
Achieve the purpose that prevent disease, promote salivary secretion, enhance oral cavity self-purification capacity, keep the kilter and function in oral cavity, drops
The incidence of the infection such as low oral cavity, respiratory tract, and be conducive to increase the comfort level of patient's physiology and psychology, improve minimal invasive treatment's matter
Amount.
Currently, the product about oral cavity nursing agent has, such as:
1, patent application CN201710310888.2 is related to a kind of pure natural oral nursing liquid, it contain propolis, radix scutellariae,
Green tea, Radix Glycyrrhizae, Chinese gall, peppermint, dandelion, mother chrysanthemum and Honegsukle flower P.E.The oral nursing liquid be a kind of pure Chinese medicinal preparation,
Without bacteriostatic agent, it has no toxic side effect, is non-stimulated, performance is stable, safe and reliable, is the good merchantable brand of common oral care.The patent
Although applying for that raw materials used is all pure Chinese medicine, it is added to the chemistry such as ethyl alcohol, polyglycerol monostearate during the preparation process
Reagent, finished product obtained still can more or less contain these chemical reagent, and ethyl alcohol is larger to the irritation in oral cavity, influences whether
Mouthfeel, smell of oral nursing liquid etc., so oral nursing liquid made from the patent application is not pure Chinese medicinal preparation, and these
The addition of chemical reagent might have insalubrious substance during the preparation process and generate, it is difficult to effectively promote.
2, patent application CN201710513133.2 discloses a kind of Blumea balsamifera oral nursing liquid, by weight, mainly
By 8~10 parts of Herba Blumeae Balsamiferae extract, 10~15 parts of active constituent stabilizer, 10~14 parts of sweetener, 20~30 parts of moisturizer, resist
5~8 parts of microbial inoculum, 8~10 parts of edible essence, 30~40 parts of edible alcohol, 50~80 parts of distilled water be made.The antibacterial agent is benzene
Formic acid；The active constituent stabilizer be one of Tween 80, Crodaret or lauryl sodium sulfate or
Two kinds；The sweetener is one or both of Aspartame, xylitol, honey element or acesulfame potassium；The moisturizer is mountain
One or both of pears alcohol, glycerol or propylene glycol；The edible essence is vanilla, Green tea essence, Mint Essence or indigo plant
One of certain kind of berries essence is a variety of.The patent application raw material is made of chemical raw material, although chemicals can play sterilization,
Antibacterial effect, but broad-spectrum antibiotic and chemical synthetic drug is used for a long time will destroy the micro- of oral cavity while removing pathogenic bacteria
Biobalance, and then cause or aggravate various oral inflammations.
3, patent application CN201811103554.9 discloses a kind of oral nursing liquid, by aloe, wight fig leaf, Sweet tea, gold
Honeysuckle flower, Poria cocos, radix ampelopsis, peppermint, walnut kernel, the fruit of glossy privet, honey, hawthorn, cassia seed, allantoin, trillium, Radix Paeoniae Alba, sorbierite,
Reasonable recipe of the invention is made in Radix Glycyrrhizae, can effectively adjust body equilibrium between yin and yang, dispersing stagnated hepatoqi, let out irascibility clearly, fundamentally press down
The growth of oral cavity germ processed, effectively dispels virus, is able to maintain oral health permanent uneasy to recur.But the patent application
To reach required technical effect, it is added to chemical reagent sorbierite in formula, it is unstable at high temperature, and have certain poison
Property, although oral nursing liquid bactericidal effect obtained is obvious, it is added to chemicals, also in human body while its sterilization
Profitable strain produce undesirable influence.
As the oral care consciousness of the mankind is gradually reinforced, all kinds of Chinese herbal medicine dental products of obvious effect, Small side effects
By chasing after stick.Therefore, existing oral care product cannot function as articles for daily use, just answer after the complication recovery from illness of oral cavity tissue
It stops using, in order to avoid cause normal flora imbalance in oral cavity and generate drug resistance.Wormwood is bitter in taste, pungent, warm, enter spleen, liver,
Kidney, have Wen Jing, dry, cold dispelling, hemostasis, anti-inflammatory, relieving asthma, cough-relieving, miscarriage prevention, antiallergy the effects of, and have and sterilize antitoxin effect；
Wherein, moxa-moxibustion be warm stimulation, with YIN and YANG balance regulating, temperature three-way meridian, disperse cold-evil, can make qi and blood coordinate, battalion Wei Hechang, blood vessels and
Benefit and the promoting flow of qi and blood circulation, dispersing blood stasis dissipating bind；Wormwood is also a kind of good food, in southern china traditional food, there is a kind of glutinous rice cake
Exactly wormwood is used to be made into as primary raw material.
In order to overcome in the prior art oral care formulations bacteriostatic active ingredients it is low, and add chemicals or using chemistry
Prepared by reagent, manufactured goods are not pure Chinese medicine product, poor, poor taste that there are stability, the easily drawbacks such as precipitating, and nurses effect
Fruit is bad.
Summary of the invention
The present invention is in order to solve the above technical problems, provide a kind of fresh breath oral nursing liquid and preparation method and use
Method.
In order to reach purpose described above, the invention adopts the following technical scheme:
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 65~95 parts of wormwood hydrosol, radix pseudostellariae
45~75 parts, 30~60 parts of peppermint, 30~60 parts of jasmine, 25~55 parts of field pennycress, 25~55 parts of the shell of areca nut, wrinkled giant hyssop 35~55
Part, 50~80 parts of eupatorium extracting solution.
Further, a kind of fresh breath oral nursing liquid, is made of raw material from the following weight: wormwood hydrosol
75~85 parts, 55~65 parts of radix pseudostellariae, 40~50 parts of peppermint, 40~50 parts of jasmine, 35~45 parts of field pennycress, the shell of areca nut 35~45
Part, 40~50 parts of wrinkled giant hyssop, 60~70 parts of eupatorium extracting solution.
Further, a kind of fresh breath oral nursing liquid, is made of raw material from the following weight: wormwood hydrosol
80 parts, 60 parts of radix pseudostellariae, 45 parts of peppermint, 45 parts of jasmine, 40 parts of field pennycress, 40 parts of the shell of areca nut, 45 parts of wrinkled giant hyssop, eupatorium extracting solution 75
Part.
Further, the wormwood hydrosol the preparation method comprises the following steps: clean wormwood is put into drift 3~5s of soup in boiled water, take
It is put into 4~6d of immersion in sterile cold water out, is then fed into wall-breaking machine polishing and wormwood hydrosol is made.
Further, a kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 6~8 times of radix pseudostellariae weight of pure water logging is added
8~10h is steeped, is put into iron pan and decocts, cooled to room temperature, natural filtration collects filtrate, obtains Chinese medicine liquid；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 35~40 DEG C carries out resurgence processing；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 500~600 meshes, the fresh breath oral nursing liquid is made.
Further, in step (1), the decoction is in the item that pressure is 0.05~0.1MPa, temperature is 95~100 DEG C
10~12h of decoction is carried out under part.
Further, in step (2), the airing with a thickness of 30~40mm, controlling environment temperature is 23~28 DEG C, booth
It dries in the air to water content lower than 50%.
Further, in step (2), the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when being sprayed object
The water content that control is sprayed material when expecting to carry out Chinese medicine liquid sprinkling when water content is lower than 20%, and spraying Chinese medicine liquid is not higher than
85%.
Further, in step (3), the frequency of the ultrasonic wave is 10KHZ~20KHz, and power is 350~450W, when
Between be 7~10min.
Further, application of a kind of fresh breath oral nursing liquid as described above in terms of oral care, it is described
The application method of fresh breath oral nursing liquid are as follows: oral nursing liquid is placed in the mouth containing 100~120s, or uses oral nursing liquid
Clean gauze is drenched, then with the gauze brushing teeth, is then spat, then gargled two or three times with clear water, nursing 2 on the one~
3 times, 3~5mL is used every time, and 7d is as a treatment course.
Raw material used herein has effects that as follows:
Wormwood: it Wen Jing, dries, cold dispelling, hemostasis, anti-inflammatory, relieving asthma, cough-relieving, miscarriage prevention, antiallergy.
Radix pseudostellariae: replenishing qi to invigorate the spleen, promoting production of body fluid and nourishing the lung.Tired, loss of appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration for spleen deficiency body
It is thirsty, dryness of the lung dry cough.
Peppermint: dispelling wind and heat from the body, head clearing, relieving sore-throat promoting eruption, soothing the liver promoting the circulation of qi.Affection of exogenous wind-heat, headache, abscess of throat, food stagnation
Inflatable, aphtha, toothache, sore scabies, urticaria, warm disease is from the beginning of, rubella itch, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
Jasmine: qi-regulating, open it is strongly fragrant, ward off it is dirty, and in.For diarrhea abdominal pain, red eyes swollen, sore.
Field pennycress: it is clearing heat and detoxicating, the effect of eliminating the phlegm apocenosis, it is usually used in acute appendicitis, pulmonary abscess, dysentery, postpartum blood stasis abdominal pain, carbuncle swells
Furunculosis.
The shell of areca nut: ventilating, line water detumescence.For retention of damp leading to blockage of QI, it is bored that stomach duct and abdomen is swollen, not well, edema swelling of defecating, tinea pedis
Edema, difficult urination.
Wrinkled giant hyssop: eliminating dampness with aromatics and middle preventing or arresting vomiting, delivers relieving summer-heat.
Eupatorium: there are antipyretic clear heat, dispelling damp-cold from the stomach and improving appetite and digestion, preventing or arresting vomiting.
When carrying out oral care using oral nursing liquid of the present invention, it can be combined with brushing teeth while carry out, protected with the oral cavity
After reason liquid has moistened tooth, the 60~70s that brushes teeth is carried out using electric toothbrush, after being gargled with clear water, then toothpaste is used to brush teeth；Or
Person sequentially exchanges toothpaste and using for the oral nursing liquid, i.e., is first brushed teeth with toothpaste, is then brushed teeth using the oral nursing liquid.
Fresh breath oral nursing liquid of the present invention meets as defined in " cosmetics safety technical specification " (version in 2015) standard
Sanitation performance index.
Since present invention employs above technical schemes, have the advantages that
(1) raw material used in oral nursing liquid of the present invention is Chinese herbal medicine, and is not added during the preparation process any organic
The chemical reagent such as solvent, do not add any additive as Antibacterial Constituents yet, wormwood hydrosol used have permeability it is strong,
Sterilizing, anti-inflammatory effect, in other Chinese herbal medicines of arranging in pairs or groups, oral cavity can sufficiently be killed and be inhibited to oral nursing liquid obtained
Harmful bacteria, and there is protective effect to beneficial bacterium, Oral normal flora balance is kept, and wormwood is still able to edible food,
Product obtained is the pure Chinese medicine product of Nantural non-toxic, and mouthfeel does not stimulate mildly, obtains liking for people.
(2) the application fresh breath oral nursing liquid has easy to carry, removing oral peculiar smell, inhibition plaque etc. a variety of
Advantage, while the complication such as multiple oral disease and its caused dyssomnia, stress, indigestion can also be treated, make
The advantages that being not in gingival discoloration, flora imbalance, secondary infection after, oral nursing liquid contain sterilization and bacteriostasis effect, energy
The generation of the mouth diseases such as enough good pre- anti-caries, ulcer, at the same can also clearing heat and detoxicating, swelling and pain relieving, for gingivitis, periodontal
Inflammation tool has a better effect.
(3) the application fresh breath oral nursing liquid is preferable for the prevention and treatment effect of oral problem, to oral cavity disease
The cure rate of disease is up to 82%, and total effective rate is up to 94%.
(4) the application wormwood, radix pseudostellariae, the shell of areca nut are same dirty with having invigorating the spleen to remove, and dehumidifying helps fortune, the effect of eliminating bad breath；It loses
Sauce grass heat-clearing has the effect of preventing swill invalid glycolysis；Wrinkled giant hyssop, eupatorium, jasmine, peppermint kill with with aroma and dampness elimination
The effect of bacterium deodorization, fresh breath.All medicines share plays invigorating the spleen except dirty, fresh breath, sterilization and antibacterial function altogether.
Specific embodiment
Specific embodiments of the present invention will be described in further detail below, but the invention is not limited to these realities
Mode is applied, it is claimed to still fall within the claims in the present invention for any improvement or replacement on the present embodiment essence spirit
Range.
Embodiment 1
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 65 parts of wormwood hydrosol, radix pseudostellariae 45
Part, 30 parts of peppermint, 30 parts of jasmine, 25 parts of field pennycress, 25 parts of the shell of areca nut, 35 parts of wrinkled giant hyssop, 50 parts of eupatorium extracting solution.
Further, the wormwood hydrosol is put the preparation method comprises the following steps: clean wormwood is put into drift soup 3s, taking-up in boiled water
Enter in sterile cold water and impregnate 4d, is then fed into wall-breaking machine polishing and wormwood hydrosol is made.
A kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 6 times of radix pseudostellariae weight of pure water is added and impregnates
8h is put into iron pan and decocts, cooled to room temperature, and natural filtration collects filtrate, obtains Chinese medicine liquid；The decoction is in pressure
Decoction 10h is carried out under conditions of being 95 DEG C for 0.05MPa, temperature；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 35 DEG C carries out resurgence processing；The airing with a thickness of 30mm, control ring
Border temperature is 23 DEG C, and airing to water content is lower than 50%；In the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when
Control is sprayed the water content of material when carrying out Chinese medicine liquid sprinkling when being sprayed material moisture lower than 20%, and spraying Chinese medicine liquid
Not higher than 85%；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 500 meshes, the fresh breath oral nursing liquid is made；The ultrasonic wave
Frequency is 10KHZ, power 350W, time 7min.
A kind of application of fresh breath oral nursing liquid as described above in terms of oral care, the fresh breath mouth
The application method of chamber conditioning liquid are as follows: oral nursing liquid is placed in the mouth containing 100s, or is drenched clean gauze with oral nursing liquid
It is wet, it then with the gauze brushing teeth, then spits, then gargled two or three times with clear water, nurses 2~3 times within 1st, use every time
3mL。
Embodiment 2
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 95 parts of wormwood hydrosol, radix pseudostellariae 75
Part, 60 parts of peppermint, 60 parts of jasmine, 55 parts of field pennycress, 55 parts of the shell of areca nut, 55 parts of wrinkled giant hyssop, 80 parts of eupatorium extracting solution.
Further, the wormwood hydrosol is put the preparation method comprises the following steps: clean wormwood is put into drift soup 5s, taking-up in boiled water
Enter in sterile cold water and impregnate 6d, is then fed into wall-breaking machine polishing and wormwood hydrosol is made.
A kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 8 times of radix pseudostellariae weight of pure water is added and impregnates
10h is put into iron pan and decocts, cooled to room temperature, and natural filtration collects filtrate, obtains Chinese medicine liquid；The decoction is to press
Power is 0.1MPa, temperature carries out decoction 12h under conditions of being 100 DEG C；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 40 DEG C carries out resurgence processing；The airing with a thickness of 40mm, control ring
Border temperature is 28 DEG C, and airing to water content is lower than 50%；In the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when
Control is sprayed the water content of material when carrying out Chinese medicine liquid sprinkling when being sprayed material moisture lower than 20%, and spraying Chinese medicine liquid
Not higher than 85%；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 600 meshes, the fresh breath oral nursing liquid is made；The ultrasonic wave
Frequency is 20KHz, power 450W, time 10min.
A kind of application of fresh breath oral nursing liquid as described above in terms of oral care, the fresh breath mouth
The application method of chamber conditioning liquid are as follows: oral nursing liquid is placed in the mouth containing 120s, or is drenched clean gauze with oral nursing liquid
It is wet, it then with the gauze brushing teeth, then spits, then gargled two or three times with clear water, nurses 2~3 times within 1st, use every time
5mL。
Embodiment 3
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 75 parts of wormwood hydrosol, radix pseudostellariae 55
Part, 40 parts of peppermint, 40 parts of jasmine, 35 parts of field pennycress, 35 parts of the shell of areca nut, 40 parts of wrinkled giant hyssop, 60 parts of eupatorium extracting solution.
Further, the wormwood hydrosol the preparation method comprises the following steps: clean wormwood is put into drift soup 3.5s in boiled water, take out
It is put into sterile cold water and impregnates 4.5d, be then fed into wall-breaking machine polishing and wormwood hydrosol is made.
A kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 6.5 times of radix pseudostellariae weight of pure water logging is added
8.5h is steeped, is put into iron pan and decocts, cooled to room temperature, natural filtration collects filtrate, obtains Chinese medicine liquid；It is described decoction be
Pressure is 0.06MPa, temperature carries out decoction 10.5h under conditions of being 96 DEG C；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 36 DEG C carries out resurgence processing；The airing with a thickness of 32mm, control ring
Border temperature is 24 DEG C, and airing to water content is lower than 50%；In the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when
Control is sprayed the water content of material when carrying out Chinese medicine liquid sprinkling when being sprayed material moisture lower than 20%, and spraying Chinese medicine liquid
Not higher than 85%；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 520 meshes, the fresh breath oral nursing liquid is made；The ultrasonic wave
Frequency is 12KHz, power 370W, time 8min.
A kind of application of fresh breath oral nursing liquid as described above in terms of oral care, the fresh breath mouth
The application method of chamber conditioning liquid are as follows: oral nursing liquid is placed in the mouth containing 105s, or is drenched clean gauze with oral nursing liquid
It is wet, it then with the gauze brushing teeth, then spits, then gargled two or three times with clear water, nurses 2~3 times within 1st, use every time
3.5mL。
Embodiment 4
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 85 parts of wormwood hydrosol, radix pseudostellariae 65
Part, 50 parts of peppermint, 50 parts of jasmine, 45 parts of field pennycress, 45 parts of the shell of areca nut, 50 parts of wrinkled giant hyssop, 70 parts of eupatorium extracting solution.
Further, the wormwood hydrosol the preparation method comprises the following steps: clean wormwood is put into drift soup 4.5s in boiled water, take out
It is put into sterile cold water and impregnates 5.5d, be then fed into wall-breaking machine polishing and wormwood hydrosol is made.
A kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 7.5 times of radix pseudostellariae weight of pure water logging is added
9.5h is steeped, is put into iron pan and decocts, cooled to room temperature, natural filtration collects filtrate, obtains Chinese medicine liquid；It is described decoction be
Pressure is 0.09MPa, temperature carries out decoction 11.5h under conditions of being 99 DEG C；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 39 DEG C carries out resurgence processing；The airing with a thickness of 39mm, control ring
Border temperature is 27 DEG C, and airing to water content is lower than 50%；In the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when
Control is sprayed the water content of material when carrying out Chinese medicine liquid sprinkling when being sprayed material moisture lower than 20%, and spraying Chinese medicine liquid
Not higher than 85%；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 590 meshes, the fresh breath oral nursing liquid is made；The ultrasonic wave
Frequency is 18KHz, power 430W, time 9min.
A kind of application of fresh breath oral nursing liquid as described above in terms of oral care, the fresh breath mouth
The application method of chamber conditioning liquid are as follows: oral nursing liquid is placed in the mouth containing 115s, or is drenched clean gauze with oral nursing liquid
It is wet, it then with the gauze brushing teeth, then spits, then gargled two or three times with clear water, nurses 2~3 times within 1st, use every time
4.5mL。
Embodiment 5
A kind of fresh breath oral nursing liquid, is made of raw material from the following weight: 80 parts of wormwood hydrosol, radix pseudostellariae 60
Part, 45 parts of peppermint, 45 parts of jasmine, 40 parts of field pennycress, 40 parts of the shell of areca nut, 45 parts of wrinkled giant hyssop, 75 parts of eupatorium extracting solution.
Further, the wormwood hydrosol is put the preparation method comprises the following steps: clean wormwood is put into drift soup 4s, taking-up in boiled water
Enter in sterile cold water and impregnate 5d, is then fed into wall-breaking machine polishing and wormwood hydrosol is made.
A kind of preparation method of fresh breath oral nursing liquid, comprising the following steps:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 7 times of radix pseudostellariae weight of pure water is added and impregnates
8h is put into iron pan and decocts, cooled to room temperature, and natural filtration collects filtrate, obtains Chinese medicine liquid；The decoction is in pressure
Decoction 11h is carried out under conditions of being 98 DEG C for 0.08MPa, temperature；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of 38 DEG C carries out resurgence processing；The airing with a thickness of 35mm, control ring
Border temperature is 25 DEG C, and airing to water content is lower than 50%；In the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, when
Control is sprayed the water content of material when carrying out Chinese medicine liquid sprinkling when being sprayed material moisture lower than 20%, and spraying Chinese medicine liquid
Not higher than 85%；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, ultrasound
Wave processing, is then fed into wall-breaking machine and was crushed to 550 meshes, the fresh breath oral nursing liquid is made；The ultrasonic wave
Frequency is 15KHz, power 400W, time 8.5min.
A kind of application of fresh breath oral nursing liquid as described above in terms of oral care, the fresh breath mouth
The application method of chamber conditioning liquid are as follows: oral nursing liquid is placed in the mouth containing 110s, or is drenched clean gauze with oral nursing liquid
It is wet, it then with the gauze brushing teeth, then spits, then gargled two or three times with clear water, nurses 2~3 times within 1st, use every time
4mL。
Comparative example 1
It is carried out according to the embodiment in patent application CN201710310888.2.
Comparative example 2
It is carried out according to the embodiment in patent application CN201710513133.2.
Comparative example 3
It is carried out according to the embodiment in patent application CN201811103554.9.
The technical effect can be reached in order to further illustrate the present invention, do following experiment:
One, toxicity test
1, acute toxicity test is carried out with mouse
Sign comparable mouse 100 are chosen, is randomly divided into 5 groups, respectively the oral nursing liquid made from Examples 1 to 5
To mouse feeding, each 100 ± 30/mL of feeding of every mouse, once a day.The dose ratio of the feeding is washed once to people are daily
The dosage that head uses is big.As a result mouse none only there is intoxicating phenomenon or death.
2, long term toxicity test is carried out with SD rat
Sign comparable SD rat 100 are chosen, is randomly divided into 5 groups, respectively the oral care made from Examples 1 to 5
Liquid, give SD feeding rats, each 240~250mL of feeding of every SD rat, once a day, continuous feeding 3 months.As a result SD is big
Mouse none only there is intoxicating phenomenon or death.
By the above toxicity test it is found that fresh breath oral nursing liquid produced by the present invention is safe.In rodent
Acute and long term toxicity experiment in, do not find that fresh breath oral nursing liquid produced by the present invention has apparent toxicity and pair
Effect.
Two, stability test
By oral nursing liquid made from the embodiment of the present invention 1 be placed on temperature be 40~50 DEG C at electro-heating standing-temperature cultivator in
It places 35~45 days, after then restoring room temperature, observes its stability；By oral nursing liquid made from embodiment 2 in temperature 0~50
It heats up or cools down processing 15~30 days repeatedly between DEG C, after then restoring room temperature, observe its stability；3 oral cavity of embodiment is protected
Reason liquid replaces storage 3 times in the case where -5 DEG C of temperature, room temperature are with 40 DEG C, and storage for 24 hours, i.e., is stored for 24 hours, then at room temperature at -5 DEG C every time
Storage for 24 hours, is then placed in 40 DEG C of insulating boxs and stores for 24 hours, circuit sequentially 3 times, observe its stability；4 oral cavity of embodiment is protected
Reason liquid is stored 1 week at -5 DEG C, observes its stability.As a result, it has been found that oral nursing liquid made from the application is in above-mentioned treatment process
In without precipitating, peculiar smell, discoloration iso-metamorphism phenomenon.
Three, fresh breath effect test
In Guizhou Province hospital screen 800 be diagnosed as saprodontia, oral peculiar smell, gingivitis, periodontitis, bleeding gums,
The volunteer patients of toothache, the age, wherein male 400, were randomly divided into 8 groups by women 400 at 20~65 years old, and every group 100,
Wherein, totally 5 groups of experimental group, totally 3 groups of control group, experimental group is respectively adopted oral nursing liquid made from Examples 1 to 5 and is gargled
Mouthful, control group is respectively adopted oral nursing liquid made from comparative example 1~3 and gargles, and each group volunteer patients, which are used continuously 2 weeks, is
1 course for the treatment of, with 2 courses for the treatment of.Volunteer patients are allowed to score the sense organs such as mouthfeel, the smell of oral nursing liquid used, sensory evaluation
Full marks very, and make a record.Curative effect situation criterion are as follows: cure: malaise symptoms disappear, the symptoms such as halitosis, oral cavity discomfort
It disappears；Effective: malaise symptoms mitigate or partial disappearance, oral cavity malaise symptoms are improved；Invalid: malaise symptoms are unchanged.It is real
It is as shown in table 1 below to test result.
Table 1
By 1 experimental data of table it is found that the application fresh breath oral nursing liquid sensory evaluation scores are higher, for oral problem
Therapeutic effect is preferable, and cure rate is up to 82%, and total effective rate is up to 94%, and embodiment 5 relative to other embodiments effect more
It is good.
In conclusion the application fresh breath oral nursing liquid has easy to carry, removing oral peculiar smell, inhibition plaque
Etc. a variety of advantages, while it is concurrent to treat multiple oral disease and its caused dyssomnia, stress, indigestion etc.
The advantages that disease is not in gingival discoloration, flora imbalance, secondary infection after use, oral nursing liquid contain sterilization and antibacterial work
With, be capable of the generation of the mouth diseases such as good pre- anti-caries, ulcer, while can also clearing heat and detoxicating, swelling and pain relieving, for gum
Scorching, periodontitis tool has a better effect.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, nothing
By from the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended
Claim rather than above description limit, it is intended that by the institute in the meaning and scope for the equivalent loins for falling in claim
It changes and includes within protection scope of the present invention.
Claims (10)
1. a kind of fresh breath oral nursing liquid, which is characterized in that be made of raw material from the following weight: wormwood hydrosol 65~95
Part, 45~75 parts of radix pseudostellariae, 30~60 parts of peppermint, 30~60 parts of jasmine, 25~55 parts of field pennycress, 25~55 parts of the shell of areca nut, the leaves of pulse plants
It is 35~55 parts, 50~80 parts of eupatorium extracting solution fragrant.
2. a kind of fresh breath oral nursing liquid according to claim 1, which is characterized in that by the raw material of following parts by weight
It is made: 75~85 parts of wormwood hydrosol, 55~65 parts of radix pseudostellariae, 40~50 parts of peppermint, 40~50 parts of jasmine, field pennycress 35~45
Part, 35~45 parts of the shell of areca nut, 40~50 parts of wrinkled giant hyssop, 60~70 parts of eupatorium extracting solution.
3. a kind of fresh breath oral nursing liquid according to claim 1, which is characterized in that by the raw material of following parts by weight
It is made: 80 parts of wormwood hydrosol, 60 parts of radix pseudostellariae, 45 parts of peppermint, 45 parts of jasmine, 40 parts of field pennycress, 40 parts of the shell of areca nut, wrinkled giant hyssop 45
Part, 75 parts of eupatorium extracting solution.
4. a kind of preparation method of described in any item fresh breath oral nursing liquids, feature exist according to claim 1~3
In: the wormwood hydrosol floats 3~5s of soup the preparation method comprises the following steps: clean wormwood is put into boiled water, and taking-up is put into sterile cold water
4~6d of middle immersion is then fed into wall-breaking machine polishing and wormwood hydrosol is made.
5. a kind of preparation method of fresh breath oral nursing liquid according to claim 4, which is characterized in that including following
Step:
(1) radix pseudostellariae, the shell of areca nut and wrinkled giant hyssop are weighed according to parts by weight, and 6~8 times of radix pseudostellariae weight of pure water is added and impregnates 8
~10h, is put into iron pan and decocts, cooled to room temperature, and natural filtration collects filtrate, obtains Chinese medicine liquid；
(2) peppermint, jasmine, field pennycress are weighed according to parts by weight, under inert gas shielding, evenly laid out airing, then 35
The Chinese medicine liquid that above-mentioned half is sprayed under the conditions of~40 DEG C carries out resurgence processing；
(3) material that resurgence is handled well is uniformly mixed with wormwood hydrosol, eupatorium extracting solution and remaining Chinese medicine liquid, at ultrasonic wave
Reason, is then fed into wall-breaking machine and was crushed to 500~600 meshes, the fresh breath oral nursing liquid is made.
6. a kind of preparation method of fresh breath oral nursing liquid according to claim 5, it is characterised in that: in step
(1), described decoct is to carry out 10~12h of decoction under conditions of pressure is 0.05~0.1MPa, temperature is 95~100 DEG C.
7. a kind of preparation method of fresh breath oral nursing liquid according to claim 5, it is characterised in that: in step
(2), the airing with a thickness of 30~40mm, controlling environment temperature is 23~28 DEG C, and airing to water content is lower than 50%.
8. a kind of preparation method of fresh breath oral nursing liquid according to claim 5, it is characterised in that: in step
(2), in the resurgence treatment process, Chinese medicine liquid is performed in multiple times sprinkling, is lower than the progress of 20% when being sprayed material moisture
Chinese medicine liquid sprinkling, and control is sprayed the water content of material not higher than 85% when sprinkling Chinese medicine liquid.
9. a kind of preparation method of fresh breath oral nursing liquid according to claim 5, it is characterised in that: in step
(3), the frequency of the ultrasonic wave is 10KHZ~20KHz, and power is 350~450W, and the time is 7~10min.
10. a kind of application of the fresh breath oral nursing liquid in terms of oral care as described in claim 1~9, feature
It is, the application method of the fresh breath oral nursing liquid are as follows: oral nursing liquid is placed in the mouth containing 100~120s, or is used
Oral nursing liquid drenches clean gauze, then with the gauze brushing teeth, then spits, then gargled two or three times with clear water,
It nurses within 1st 2~3 times, uses 3~5mL every time.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112057387A (en) * | 2020-09-30 | 2020-12-11 | 海南鸿翼医疗器械有限公司 | Gargle for relieving oral wound pain and preparation method thereof |
| CN116548612A (en) * | 2023-06-01 | 2023-08-08 | 江中药业股份有限公司 | Composition, hawthorn and dandelion micro-bubble tablet and preparation method thereof |
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| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN107126392A (en) * | 2017-05-16 | 2017-09-05 | 何玉凤 | A kind of mouthwash solution in nursing oral cavity and preparation method thereof |
| CN107303249A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound lavender aromatic mouthwass |
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2019
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| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN107303249A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound lavender aromatic mouthwass |
| CN107126392A (en) * | 2017-05-16 | 2017-09-05 | 何玉凤 | A kind of mouthwash solution in nursing oral cavity and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112057387A (en) * | 2020-09-30 | 2020-12-11 | 海南鸿翼医疗器械有限公司 | Gargle for relieving oral wound pain and preparation method thereof |
| CN112057387B (en) * | 2020-09-30 | 2022-08-02 | 海南鸿翼医疗器械有限公司 | Gargle for relieving oral wound pain and preparation method thereof |
| CN116548612A (en) * | 2023-06-01 | 2023-08-08 | 江中药业股份有限公司 | Composition, hawthorn and dandelion micro-bubble tablet and preparation method thereof |
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Application publication date: 20191008 |