CN106265452A - A kind of green lemon toothpaste and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of green lemon toothpaste and preparation method thereof, the raw material making described toothpaste comprises fruit and vegerable extracting solution and the concentrated liquid of tradition Chinese medicine, and raw material and the parts by weight thereof of making described fruit and vegerable extracting solution are: green lemon 20 30 parts, Herba Portulacae 10 15 parts, Fructus Benincasae sarcocarp 10 15 parts, Herba Lactucae versicoloris 6 10 parts；Raw material and the parts by weight thereof of making described the concentrated liquid of tradition Chinese medicine are: Radix Scutellariae 68 parts, Flos Lonicerae 10 15 parts, Radix Gentianae 35 parts, Flos Chrysanthemi Indici 10 15 parts, Herba Houttuyniae 8 12 parts, Fructus Forsythiae 8 12 parts, Cortex Magnoliae Officinalis 35 parts, Rhizoma Cimicifugae 13 parts, Galla Chinensis 69 parts, the Radix Paeoniae Alba 69 parts, Eucalyptus globulus Labill 7 10 parts, Radix Glycyrrhizae Preparata 47 parts.This toothpaste can play energy antibacterial and anti-inflammation functions, the odontopathy such as effectively suppression pathogenic bacterium grow, prophylactic treatment periodontitis, moreover it is possible to pre-anti-bacteria virus is propagated to whole body by blood, causes more serious disease while cleaning tooth-whitening.

Description

A kind of green lemon toothpaste and preparation method thereof

Technical field

The present invention relates to oral cleaning nursing article technical field, especially a kind of green lemon toothpaste.

Background technology

Periodontitis is to invade gingiva and the chronic inflammatory disease of periodontal tissue, is a kind of destructive disease, and it is mainly characterized by tooth The week formation of bag and the inflammation of bag wall, frontal resorption and tooth gradually loosen, and it is cause adult's loss of tooth main Reason.Primary disease is many to be stung wound etc. cause because bacterial plaque, tartar, food impaction, ill fitting prosthesis, and various focusing depths represented swelling makes simultaneously Bacterial plaque is piled up and is increased the weight of, and is prolonged by expanding under gingivally on gum.Due to microecological environment under gum, subgingival plaque grow a large amount of The Periodontal Pathogens that virulence is bigger, such as gingiva bacteroid, intermediate bacillus, spirillum etc., makes the increased inflammation of gingiva expansion prolong, Cause periodontal pocket to be formed and frontal resorption, cause periodontitis.It is the cancer that continues, cardiovascular and cerebrovascular vessel disease that periodontitis is come to a conclusion by medical circle After disease, threaten the third-largest killer that human body is healthy, be also oral health " number one killer ".The Major Clinical of periodontitis Performance is that gingivitis, hemorrhage, periodontal pocket formation, frontal resorption, phatnoma bone height reduce, odontoseisis displacement, chew nothing Power, severe patient tooth can self falling or cause pulling out of tooth.There are substantial amounts of pathogenic bacterium in cementopathia position, these are thin Bacterium can produce endotoxin and invade blood, causes the change of clotting mechanism and hematoblastic degeneration, also can directly stimulate blood vessel, lead Cause arteriolospasm.If coronary artery is got involved, shrink spasm, add the effect of small thrombosis, will cause acute The generation of myocardial infarction.Periodontitis is the risk factor of arteriosclerosis and acute myocardial infarction.Infective endocarditis and periodontal Disease also has relation.Periodontitis causes toothache to allow patient suffering can't bear, simultaneously as every diseased tooth, itself be all one not The disconnected hotbed producing, replicating a large amount of pathogenic bacteria virus, every day is all being propagated to whole body by blood, and then it is strong to encroach on whole health Health, during this time, traditional oral cavity odontopathy Therapeutic Method, it has to take destructive exodontia therapy (to include exodontia, edge Tooth, root canal etc.), stop oral disease to deteriorate healthy various adverse effects, now have to sacrifice tooth Tooth is cost, and the life that patient can be given later causes the biggest inconvenience.If can be by the method for daily cleaning of teeth to periodontal disease Disease is prevented, or carries out disease initial therapy suppression disease progression, and prevention severe total infects, then can greatly reduce trouble The misery of person.

Summary of the invention

Present invention aim at providing a kind of green lemon toothpaste and preparation method thereof, this toothpaste contains the fruits such as green lemon Vegetables, Effective Component of Chinese Medicine can play energy antibacterial and anti-inflammation functions, have by daily process of brushing teeth while cleaning tooth-whitening The odontopathy such as suppression pathogenic bacterium grow effect, prophylactic treatment periodontitis, moreover it is possible to pre-anti-bacteria virus is propagated to whole body by blood, causes More serious disease.

To achieve these goals, the technical scheme that the present invention provides is as follows:

A kind of green lemon toothpaste, raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.1-0.3%, thin Lotus oil 0.3-0.5%, glycerol 7-10%, silicon dioxide 35-40%, sodium lauryl sulphate 0.5-0.7%, whitening agent 1-3%, Fruit and vegerable extracting solution 10-15%, the concentrated liquid of tradition Chinese medicine 5-10%, surplus is distilled water；Make described fruit and vegerable extracting solution raw material and Parts by weight are: green lemon 20-30 part, Herba Portulacae 10-15 part, Fructus Benincasae sarcocarp 10-15 part, Herba Lactucae versicoloris 6-10 part；Make described in The raw material of medicine concentrated solution and parts by weight thereof are: Radix Scutellariae 6-8 part, Flos Lonicerae 10-15 part, Radix Gentianae 3-5 part, Flos Chrysanthemi Indici 10-15 part, Herba Houttuyniae 8-12 part, Fructus Forsythiae 8-12 part, Cortex Magnoliae Officinalis 3-5 part, Rhizoma Cimicifugae 1-3 part, Galla Chinensis 6-9 part, Radix Paeoniae Alba 6-9 part, Eucalyptus globulus Labill 7-10 part, Radix Glycyrrhizae Preparata 4-7 part.

Preferably, the one during described whitening agent is sodium phytate, aloin, glycyrrhizin and glucoseoxidase Or it is multiple.

Preferably, described whitening agent is the mixture of aloin and glucoseoxidase, aloin and Fructus Vitis viniferae in whitening agent The mass ratio of carbohydrate oxidase is 3:2.

Preferably, described green lemon, Herba Portulacae, Fructus Benincasae sarcocarp, Herba Lactucae versicoloris are cut into small pieces mixing after cleaning, addition and mixture The deionized water of the quality such as material stands 0.5h after squeezing the juice, and crosses 200 mesh drainage screen gained filtrates and is described fruit and vegerable extracting solution.

Preferably, raw material and the parts by weight thereof of making described fruit and vegerable extracting solution are: green lemon 25 parts, Herba Portulacae 13 parts, Fructus Benincasae sarcocarp 12 parts, Herba Lactucae versicoloris 8 parts.

Preferably, the preparation method of described the concentrated liquid of tradition Chinese medicine is: Radix Scutellariae, Flos Lonicerae, Radix Gentianae, Flos Chrysanthemi Indici, Herba Houttuyniae, company Stick up, Cortex Magnoliae Officinalis, Rhizoma Cimicifugae, Galla Chinensis, the Radix Paeoniae Alba, Eucalyptus globulus Labill, Radix Glycyrrhizae Preparata co-grinding obtain 100 mesh mixed-powders, and gained mixed-powder adds The water soaking 1h of gross mass multiple 5 times, slow fire boiling 1h, cross 200 mesh drainage screens and obtain filtrate after decoction, gained filtrate is cooled to room Adding in low-temperature vacuum thickener after temperature, cryoconcentration (less than 40 DEG C) to relative density is the concentration of 1.20 ± 0.02 (40 DEG C) Liquid.

Preferably, raw material and the mass percent thereof of making described toothpaste be: make described the concentrated liquid of tradition Chinese medicine raw material and Its parts by weight are: Radix Scutellariae 7 parts, Flos Lonicerae 12 parts, Radix Gentianae 4 parts, Flos Chrysanthemi Indici 12 parts, Herba Houttuyniae 10 parts, Fructus Forsythiae 10 parts, Cortex Magnoliae Officinalis 4 Part, Rhizoma Cimicifugae 2 parts, Galla Chinensis 7 parts, the Radix Paeoniae Alba 8 parts, Eucalyptus globulus Labill 9 parts, Radix Glycyrrhizae Preparata 5 parts.

Preferably, raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.2%, and Oleum menthae 0.4% is sweet Oil 8%, silicon dioxide 37%, sodium lauryl sulphate 0.6%, whitening agent 2%, fruit and vegerable extracting solution 13%, the concentrated liquid of tradition Chinese medicine 7%, distilled water 31.8%.

The invention also discloses the preparation method of described green lemon toothpaste: by Oleum Caryophylli, Oleum menthae, glycerol, titanium dioxide Silicon, sodium lauryl sulphate, whitening agent, fruit and vegerable extracting solution, the concentrated liquid of tradition Chinese medicine and distilled water are weighed after getting the raw materials ready respectively, pre-dispersed Still disperses, mixes, open cream still vacuum pump processed and suck above-mentioned liquid material, then drive scraper, agitator and colloid mill, depend on after 50 minutes Secondary closedown colloid mill, agitator and scraper, vacuum breaker, obtain green lemon toothpaste.

Food debris remains on tooth after the meal, meeting breed bacteria in oral cavity, causes the disease such as periodontitis, pericoronitis, The especially existence of wisdom teeth, it is easier to food residual, diseases induced, sooner or later or brush teeth after the meal and can play to a certain extent The effect of cleaning tooth, but, the often formula of toothpaste the most on the market is fairly simple, and the main effect focusing on cleaning whitening Really, in terms of prophylactic treatment periodontitis, effect is the most barely satisfactory, and pathogenic bacterium cannot be suppressed to enter blood circulation, causes other tight Weight disease.The toothpaste of the present invention is using the extract component of the fruit and vegerable such as green lemon and Chinese medicine as principle active component, it is achieved antibacterial disappear Scorching effect, by brushing teeth while cleaning tooth-whitening, plays energy antibacterial and anti-inflammation functions, and effectively suppression pathogenic bacteria virus is grown Raw, the disease such as pre-preventing parodontitis, prevent to be propagated to whole body by blood by pathogenic bacteria virus simultaneously, cause more serious disease. Traditional Chinese doctors ' theory, preferably natural material preparation, formula is combined during preparing fruit and vegerable extracting solution and the concentrated liquid of tradition Chinese medicine Safe without toxic side effect, compatibility is proper, in selected raw material:

Green lemon: Fructus Citri Limoniae is one of fruit having medical value most, it rich in vitamin C, saccharide, calcium, phosphorus, Ferrum, vitamin B1, vitamin B2, nicotinic acid quininic acid, citric acid, malic acid, Hesperidin, naringin, coumarin, a large amount potassium element With low amounts sodium element etc., Fructus Citri Limoniae has removing heat-phlegm effect, and Fructus Citri Limoniae is rich in vitamin C, and the effect playing human body is just as natural Antibiotic, has anti-inflammation, strengthens the multiple efficacies such as body immunity, and Fructus Citri Limoniae, rich in vitamin C and Citrin, can strengthen Blood vessel elasticity and toughness, can prevent and treat hypertension and myocardial infarction symptoms；

Herba Portulacae: cold in nature, sweet in the mouth acid, enter the heart, liver, spleen, large intestine channel, have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, Diuretic dries, and dissipates blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae is to dysentery bacterium, Bacillus typhi There is stronger inhibitory action with escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", simultaneously Herba Portulacae is also rich in vitamin C, and vitamin C has good antioxidation can be with whitening nourishes rough skin, and modern medicine finds, Herba Portulacae has higher nutritive value and medical value, except containing nutrition units such as conventional proteins,vitamins,and mineralses Outside element, Herba Portulacae is possibly together with unique bioactive ingredients, it is possible to strengthens the activity of Human Epithelial Cells, helps lend some impetus to ulcer And healing；

Fructus Benincasae: sweet in the mouth, light, cool in nature, has the lung moistening and production of body fluid promoting, reduces phlegm and quench the thirst, inducing diuresis to remove edema, clearing summer heat, removing toxic substances and promoting pus discharge, available , expectorant heat syndrome cough thirsty in summer-heat is breathed heavily, edema, tinea pedis, distension, quench one's thirst, acne, speckle, proctoptosis, hemorrhoid etc., moreover it is possible to solve fish, alcoholism；

Herba Lactucae versicoloris: cold in nature, bitter in the mouth, there is the effect of eliminating inflammation and expelling toxin, it is adaptable to appendicitis, enteritis, cervicitis, mastitis, flat The diseases such as Fructus Persicae body inflammation, pharyngolaryngitis, acute icterohepatitisshock, bacillary dysentery. can anti-curing cancers, function of gallbladder promoting liver, anti-gastric-ulcer, external can Treatment furuncle and phyma, beneficially wound healing, ease the pain, and it is that hepatopathy is had certain curative effect.Due to the iron content in Herba Lactucae versicoloris Height, can prevent anemia and promote upgrowth and development of children, and edible Herba Sonchi Oleracei helps lend some impetus to the synthesis of people's internal antibody, enhancing body Immunity is eaten for a long time and can improve body immunity, prevents disease, promotes cerebral function, containing vitamin C 88 milligrams in Herba Lactucae versicoloris, Carotene 3.22 milligrams, is 2.1 and 2.3 times of content in Herba Spinaciae respectively.In Herba Lactucae versicoloris tender leaf, amino acid classes is complete, and various Between aminoacid, ratio is suitable；

Radix Scutellariae: bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive, cures mainly epidemic febrile disease, upper breathing The diseases such as road infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle are yellow The clinical antibiotic property of a kind of reed mentioned in ancient books is better than Rhizoma Coptidis, and does not develops immunity to drugs；

Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind, cure mainly swollen Completely descending disease, epidemic febrile disease to generate heat, the disease such as pyretic toxicity carbuncle and ulcer and tumor, it makees thirsty, hyperhidrosis unhappiness, enteritis, bacterium for dizzy dizzy, xerostomia Dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, the parotid gland The diseases such as inflammation, suppurative tonsillitis all have certain curative effect, experiment in vitro to show, this product is to various pathogens such as golden yellow Fructus Vitis viniferae Coccus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. all have and necessarily press down Make use, the most effective to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus；

Radix Gentianae: eliminating pathogen in the liver gallbladder excess-fire, except damp-heat in lower-JIAO.Treating the liver is through intenseness of heat, and infantile convulsion is manic, encephalitis B, headache, conjunctival congestion, pharynx Bitterly, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen, for damp and hot yellow cellulitis, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, Deafness, hypochondriac pain, bitter taste, convulsion with spasms, the gentiopicrin contained by Radix Gentianae has direct hepatoprotective effect, and gentiopicrin can also stimulate stomach Liquid stomach function regulating takes secretion, has digestion promoting function, and test tube method proves that Radix Gentianae decoct is to bacillus pyocyaneus, Bacillus proteus, Bacillus typhi, dysentery Bacillus, staphylococcus aureus etc. has inhibitory action in various degree；

Flos Chrysanthemi Indici: cold nature, has dispelling wind and heat pathogens, subduing swelling and detoxicating, can treat furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, head The disease such as dizziness bitterly；

Herba Houttuyniae: cold nature, bitter in the mouth, heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, control pneumonia, lung abscess, hematodiarrhoea, malaria Disease, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies, Herba Houttuyniae can strengthen the phagocytic activity of WBC, Improving serum properdin, Herba Houttuyniae improves immunity of organisms, and the treatment to venereal infection has great significance, and carries in Herba Houttuyniae Obtain a kind of yellow oil, various microorganisms (especially yeast and mycete) are all had inhibitory action, the hammer to hemolytic Bacterium, staphylococcus aureus, hemophilus influenza, micrococcus catarrhalis, streptococcus pneumoniae have obvious inhibitory action；

Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has in vitro Antibacterial action, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, Fructus Vitis viniferae Coccus, streptococcus etc.；

Cortex Magnoliae Officinalis: toil, temperature, warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant, control chest and abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappears, expectorant Drink is breathed with cough, cold-damp dysentery, and its aqueous solution has certain bacteriostasis to staphylococcus aureus, sarcina and bacillus subtilis, Cortex Magnoliae Officinalis also has antibacterial activity to Diplococcus pneumoniae and dysentery bacterium；

Rhizoma Cimicifugae: pungent, micro-sweet, is slightly cold, and delivers rash, heat-clearing and toxic substances removing, rises and lifts yang-energy, for headache due to pathogenic wind-heat, and toothache, aphtha, Laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle, proctoptosis, uterine prolapse；

Galla Chinensis: cold in nature, sour in the mouth, puckery, there is the effects such as pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore, main Controlling the diseases such as chronic cough of deficiency lung, chronic diarrhea chronic dysentery, hemorrhoidal bleeding of having blood in stool, carbuncle sore tumefacting virus, Skin wet and rotten, Galla Chinensis decoct is to Staphylococcus aureus Bacterium, beta hemolytic streptococcus, streptococcus pneumoniae, bacillus pyocyaneus, dysentery bacterium, anthrax bacillus, diphtheria corynebacterium, escherichia coli, wound Cold and Salmonella paratyphi etc. all has the most antibacterial and bactericidal action；

The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, it is slightly cold, there is the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, Being applicable to fever due to yin deficiency, menoxenia, the chest and abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, band are inferior Disease, Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus Deng；

Eucalyptus globulus Labill: the micro-hardship pungent, micro-of taste, property is put down.Dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, and anticorrosion is antipruritic.For prevent influenza, Epidemic cerebrospinal meningitis, controls upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery Disease, filaricide；Burn and scald, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin are controlled in external Sterilization；

Radix Glycyrrhizae Preparata: containing multiple chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and resistance state Reagentia, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, Lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.

The traditional Chinese medical science thinks that the Etiological of periodontitis is to attack outside wind heat, gastrointestinal intrinsic heat, and liver and gall fire is contained caused, the toothpaste of the present invention Contained natural fruit and vegetables and the effective ingredient of Chinese medicine extract, use antibacterial bacteriostatic, heat-clearing and toxic substances removing, the method for soothing the liver pathogenic fire purging, have The oral diseases such as effect preventing and treating periodontitis.Make in the raw material of principle active component, Radix Scutellariae, Flos Lonicerae, Herba Portulacae, Herba Lactucae versicoloris, Radix Gentianae, Herba Houttuyniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Galla Chinensis, green lemon, the Radix Paeoniae Alba, Eucalyptus globulus Labill share has good bactericidal and bacteriostatic effect, can be residual in cleaning Effectively kill pathogenic bacterium while staying the food debris on tooth, prevent and treat all kinds of oral cavity infection；Radix Scutellariae, Herba Lactucae versicoloris, Flos Lonicerae, Dens Equi Herba Amaranthi tricoloris, Flos Chrysanthemi Indici, Herba Houttuyniae, Fructus Benincasae, Fructus Forsythiae, Rhizoma Cimicifugae, green lemon, Eucalyptus globulus Labill share the effect also with heat-clearing and toxic substances removing, Radix Gentianae, Cortex Magnoliae Officinalis, Galla Chinensis, the Radix Paeoniae Alba share the effect that can be total to long memorial liver pathogenic fire purging, and the effective ingredient of toothpaste acts in oral cavity, at cleaning tooth and mouth Chamber, while anti-inflammation, it is also possible to removes oral cavity endogenous wind pathogenic heat poison, regulates internal environment of oral cavity, effectively prevents and treats multiple oral cavity disease Sick；Raw material Radix Glycyrrhizae can make the property of medicine more gentle with coordinating the actions of various ingredients in a prescription, promotes drug effect, the comprehensive synergism of each material effective component, joins 5 is proper, while safely and effectively cleaning tooth, can effectively prevent and treat the multiple diseases such as periodontitis.In addition, raw material green grass or young crops lemon Lemon also rich in Citrin can strengthen blood vessel wall intensity, protect intraoral blood capillary, recover blood capillary elastic, have Effect prevents from being caused affected part Permeability of Capillary Wall to increase by inflammation, causes substantial amounts of pathogenic bacterium to enter blood through capillary wall Liquid, thus cut off the pathogenic bacterium path with blood born, effectively prevention reduces the complication generation of other histoorgans.Raw material is blue or green Fructus Citri Limoniae also has aromatic odor, share with Oleum Caryophylli and Oleum menthae, can cover the taste of part Chinese medicine so that toothpaste abnormal smells from the patient is more Pleasant, facilitate life-time service.Citric acid contained by green lemon makes this toothpaste show faintly acid, more easily dissolves during cleaning tooth With removing tartar, play the effect preferably cleaning tooth-whitening.This toothpaste uses natural fruit and vegetables and Chinese medicine extract as having Effect becomes, it is achieved the effect of anti-inflammation, and formula more safety is gentle, and life-time service has no side effect, and can be used for periodontal oral cavity disease Sick daily protection.

Beneficial effects of the present invention: providing a kind of green lemon toothpaste and preparation method thereof, this toothpaste contains green lemon Can play and can make by anti-inflammation by daily process of brushing teeth while cleaning tooth-whitening Deng fruit and vegerable, Effective Component of Chinese Medicine With, the odontopathy such as effectively suppression pathogenic bacterium grow, prophylactic treatment periodontitis, moreover it is possible to pre-anti-bacteria virus is passed to whole body by blood Broadcast, cause more serious disease.Specifically:

(1) natural fruit and vegetables contained by the toothpaste of the present invention and the effective ingredient of Chinese medicine extract, make principle active component Raw material in, Radix Scutellariae, Flos Lonicerae, Herba Portulacae, Herba Lactucae versicoloris, Radix Gentianae, Herba Houttuyniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Galla Chinensis, green lemon, the Radix Paeoniae Alba, indigo plant Eucalyptus globulus is share has good bactericidal and bacteriostatic effect, effectively can kill pathogenic while cleaning remains in the food debris on tooth Bacterium, prevents and treats all kinds of oral cavity infection；Radix Scutellariae, Herba Lactucae versicoloris, Flos Lonicerae, Herba Portulacae, Flos Chrysanthemi Indici, Herba Houttuyniae, Fructus Benincasae, Fructus Forsythiae, Rhizoma Cimicifugae, blue or green lemon Lemon, Eucalyptus globulus Labill share the effect also with heat-clearing and toxic substances removing, and Radix Gentianae, Cortex Magnoliae Officinalis, Galla Chinensis, the Radix Paeoniae Alba share the effect that can be total to long memorial liver pathogenic fire purging, tooth The effective ingredient of cream acts in oral cavity, in cleaning tooth and oral cavity, while anti-inflammation, it is also possible to remove ailment said due to cold or exposure in oral cavity Pyretic toxicity, regulates internal environment of oral cavity, effectively prevents and treats multiple oral disease；Raw material Radix Glycyrrhizae can make the property of medicine more gentle with coordinating the actions of various ingredients in a prescription, Promoting drug effect, the comprehensive synergism of each material effective component, compatibility is proper, while safely and effectively cleaning tooth, and can be effective The multiple diseases such as preventing and treating periodontitis.

(2) raw material green lemon also rich in Citrin can strengthen blood vessel wall intensity, protect intraoral blood capillary, Recover blood capillary elastic, effectively prevent from being caused affected part Permeability of Capillary Wall to increase by inflammation, cause substantial amounts of pathogenic bacterium Entering blood through capillary wall, thus cut off the pathogenic bacterium path with blood born, effectively prevention reduces other organizers The complication of official produces.

(3) raw material green lemon has aromatic odor, share with Oleum Caryophylli and Oleum menthae, can cover the taste of part Chinese medicine, Make toothpaste abnormal smells from the patient more pleasant, facilitate life-time service.Citric acid contained by green lemon makes this toothpaste show faintly acid, cleans tooth More easily dissolve during tooth and remove tartar, playing the effect preferably cleaning tooth-whitening.This toothpaste use natural fruit and vegetables and Chinese medicine extract is as effectively becoming, it is achieved the effect of anti-inflammation, and formula more safety is gentle, and life-time service has no side effect, Can be used for the daily protection of periodontal oral disease.

Detailed description of the invention

According to following embodiment, the present invention be may be better understood.But, as it will be easily appreciated by one skilled in the art that reality Execute concrete material proportion, process conditions and result thereof described by example be merely to illustrate the present invention and not should also without limitation on The present invention described in detail in claims.

Embodiment 1

A kind of green lemon toothpaste, raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.2%, Oleum menthae 0.4%, glycerol 8%, silicon dioxide 37%, sodium lauryl sulphate 0.6%, whitening agent 2%, fruit and vegerable extracting solution 13%, Chinese medicine Concentrated solution 7%, distilled water 31.8%；Described whitening agent is the mixture of aloin and glucoseoxidase, Aloe in whitening agent The mass ratio of element and glucoseoxidase is 3:2；Raw material and the parts by weight thereof of making described fruit and vegerable extracting solution are: green lemon 25 Part, Herba Portulacae 13 parts, Fructus Benincasae sarcocarp 12 parts, Herba Lactucae versicoloris 8 parts；Raw material and the mass percent thereof of making described toothpaste be: makes institute Raw material and the parts by weight thereof of stating the concentrated liquid of tradition Chinese medicine are: Radix Scutellariae 7 parts, Flos Lonicerae 12 parts, Radix Gentianae 4 parts, Flos Chrysanthemi Indici 12 parts, Herba Houttuyniae 10 parts, Fructus Forsythiae 10 parts, Cortex Magnoliae Officinalis 4 parts, Rhizoma Cimicifugae 2 parts, Galla Chinensis 7 parts, the Radix Paeoniae Alba 8 parts, Eucalyptus globulus Labill 9 parts, Radix Glycyrrhizae Preparata 5 parts.

The preparation method of this toothpaste comprises the following steps:

(1) fruit and vegerable extracting solution is prepared: described green lemon, Herba Portulacae, Fructus Benincasae sarcocarp, Herba Lactucae versicoloris are cut into small pieces after cleaning mixing, The deionized water of the quality such as addition and mixed material stands 0.5h after squeezing the juice, and crosses 200 mesh drainage screen gained filtrates and is described fruit Vegetables extracting solution；

(2) prepare the concentrated liquid of tradition Chinese medicine: Radix Scutellariae, Flos Lonicerae, Radix Gentianae, Flos Chrysanthemi Indici, Herba Houttuyniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Rhizoma Cimicifugae, five times Son, the Radix Paeoniae Alba, Eucalyptus globulus Labill, Radix Glycyrrhizae Preparata co-grinding obtain 100 mesh mixed-powders, and gained mixed-powder adds the water of gross mass multiple 5 times Soaking 1h, slow fire boiling 1h, cross 200 mesh drainage screens and obtain filtrate after decoction, gained filtrate adds cryogenic vacuum after being cooled to room temperature In thickener, cryoconcentration (less than 40 DEG C) to relative density is the concentrated solution of 1.20 ± 0.02 (40 DEG C)；

(3) toothpaste is prepared: by Oleum Caryophylli, Oleum menthae, glycerol, silicon dioxide, sodium lauryl sulphate, whitening agent, fruit and vegerable Extracting solution, the concentrated liquid of tradition Chinese medicine and distilled water are weighed after getting the raw materials ready respectively, disperse, mix in pre-dispersed still, open cream still vacuum pump processed Suck above-mentioned liquid material, then drive scraper, agitator and colloid mill, after 50 minutes, close colloid mill, agitator and scraper successively, broken Vacuum, obtains green lemon toothpaste.

Embodiment 2

A kind of green lemon toothpaste, raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.1%, Oleum menthae 0.3%, glycerol 7%, silicon dioxide 35%, sodium lauryl sulphate 0.5%, whitening agent 1%, fruit and vegerable extracting solution 10%, Chinese medicine Concentrated solution 5%, distilled water 41.1%；Described whitening agent is sodium phytate；Make described fruit and vegerable extracting solution raw material and Parts by weight are: green lemon 20 parts, Herba Portulacae 10 parts, Fructus Benincasae sarcocarp 10 parts, Herba Lactucae versicoloris 6 parts；Make the former of described the concentrated liquid of tradition Chinese medicine Expect and parts by weight are: Radix Scutellariae 6 parts, Flos Lonicerae 10 parts, Radix Gentianae 3 parts, Flos Chrysanthemi Indici 10 parts, Herba Houttuyniae 8 parts, Fructus Forsythiae 8 parts, Cortex Magnoliae Officinalis 3 parts, Rhizoma Cimicifugae 1 part, Galla Chinensis 6 parts, the Radix Paeoniae Alba 6 parts, Eucalyptus globulus Labill 7 parts, Radix Glycyrrhizae Preparata 4 parts.

The preparation method of the toothpaste of embodiment 2 is identical with embodiment 1.

Embodiment 3

A kind of green lemon toothpaste, raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.3%, Oleum menthae 0.5%, glycerol 10%, silicon dioxide 40%, sodium lauryl sulphate 0.7%, whitening agent 3%, fruit and vegerable extracting solution 15%, Chinese medicine Concentrated solution 10%, distilled water 20.5%；Described whitening agent is glycyrrhizin；Make raw material and the weight thereof of described fruit and vegerable extracting solution Number is: green lemon 30 parts, Herba Portulacae 15 parts, Fructus Benincasae sarcocarp 15 parts, Herba Lactucae versicoloris 10 parts；Make described the concentrated liquid of tradition Chinese medicine raw material and Its parts by weight are: Radix Scutellariae 8 parts, Flos Lonicerae 15 parts, Radix Gentianae 5 parts, Flos Chrysanthemi Indici 15 parts, Herba Houttuyniae 12 parts, Fructus Forsythiae 12 parts, Cortex Magnoliae Officinalis 5 Part, Rhizoma Cimicifugae 3 parts, Galla Chinensis 9 parts, the Radix Paeoniae Alba 9 parts, Eucalyptus globulus Labill 10 parts, Radix Glycyrrhizae Preparata 7 parts.

The preparation method of the toothpaste of embodiment 3 is identical with embodiment 1.

Embodiment 4

30 volunteers are divided into 3 groups, and use embodiment 1-3 toothpaste, morning and evening every day each brush is once, front and continuous to using Mottle index LSI after using 3 months tests respectively, and method of testing and scoring rule see Shanghai Communications University and permitted son unit Master thesis " the clinical efficacy evaluation study of a kind of novel whitening toothpaste " page 5～6 1.4.1.

LSI scoring method, concrete scoring rule is as follows:

0 point-exist without mottle；

1 point-mottle size is less than the 1/3 of facing；Degree is slight mottle (yellow or yellowish-brown)；

2 points-mottle size is less than the 2/3 of facing；Degree is moderate mottle (moderate brown)；

3 points-mottle size is more than the 2/3 of facing；Degree is severe mottle (dark-brown or black).

Statistics experimenter uses front LSI value and uses LSI value after March, calculates the front LSI meansigma methods of use and uses March Rear LSI meansigma methods, then calculate mottle index LSI rate of descent, mottle index LSI rate of descent (%)=[the front LSI meansigma methods of use- Use LSI meansigma methods after March]/use front LSI meansigma methods × 100%.Result is as shown in the table:

	Mottle index LSI rate of descent (%)
		Embodiment 1	38.9
Embodiment 2	22.3
		Embodiment 3	26.5

Test result indicate that, use the toothpaste after 3 months of embodiment 1 to 3, being decreased obviously of LSI value, the toothpaste of the present invention The toothpaste whitening effect with preferable whitening effect, especially embodiment 1 is the most obvious.

Embodiment 5 antiinflammatory pharmacological experiment

Xylol is used to cause the antiinflammatory action experimental technique of Mice Auricle acute inflammation swelling.Take healthy male Kunming kind White mice 30, body weight 18～22g, the most equal 3 groups, often group 10.Blank group (normal saline 0.1ml/ is only), it is right to treat According to group (fluocinonide cream 0.1g/ is only), toothpaste sample group (is prepared by embodiment 1,0.1g/ is only).Respectively every is organized during experiment Inside and outside animal auris dextra exterior feature, two sides uniform application dimethylbenzene 0.1ml/ is only, causes inflammation, and left ear is untreated makees self-blank comparison.Smear After dimethylbenzene 30min, inside and outside every animal auris dextra exterior feature of each group, two sides uniform application group tested material sample 0.1g/ respectively is only.Give After medicine 1h, mice cervical dislocation is put to death, and cuts two auricles, washes away auris dextra exterior feature tested material sample with normal saline, and dry cotton ball is cleaned, Overlapping two auricles, take two circle auricles with the card punch of internal diameter 8mm at same position chisel, respectively at FA1004 type electronic analytical balance On weigh, it is swelling value that auris dextra sheet weight deducts left auricle weight, and data carry out statistics t inspection, and result is as shown in the table.

Group	Dosage	Auricle edema value (mg)
			Blank group	0.1ml/ is only	17.01±2.56
Treatment matched group	0.1g/ is only	11.23±1.89**
			Collutory sample controls group	0.1g/ is only	13.28±1.56**

Compare with blank group: * P ＜ 0.05, * * P ＜ 0.01.

Test result indicate that, the toothpaste of the present invention and fluocinonide cream group all can make chmice acute inflammation swelling auricle Weight significantly alleviates, hence it is evident that suppression dimethylbenzene induced mice auricle acute inflammation swelling, shows that acute inflammation is had by this collutory There is obvious antiinflammatory action.

Embodiment 6 bacteriostatic experiment

1, experimental strain: beta hemolytic streptococcus (CICC 10373)

2, bacterium culture medium: blood plate and nutrient broth medium.

3, bacteriostatic experiment divides three experimental grouies and negative control group, and experimental group A is the toothpaste of gained in embodiment 1, experiment Group B is the toothpaste of gained in embodiment 2, and experimental group C is the toothpaste of gained in embodiment 3, and negative control group is blank.

4, specific experiment step:

(1) prepared by susceptibility sense sheet: double-round board qualitative filter paper card punch is made the round scraps of paper of diameter 6mm and put into cleaning and be dried Penicillin empty bottle in, bottleneck is wrapped up with monolayer kraft paper, 121 DEG C of autoclaving 30min, then through 100 DEG C of drying, airtight preservation Standby.The most respectively the scraps of paper are dipped in 2h in the toothpaste of embodiment 1 to 3, after liquid is absorbed by the scraps of paper completely, take Going out filter paper, it is standby that susceptibility sheet is made in 50 DEG C of drying, and 5 susceptibility sense sheets prepared by every kind of unguentum, prepare 5 blank sterilizings simultaneously The scraps of paper as negative control group；

(2) prepare bacterium solution: beta hemolytic streptococcus strain is placed in 10ml nutrient broth medium, cultivate 18h for 37 DEG C； Take 0.9% aseptic sodium chloride solution that culture fluid 1ml adds 9ml, use 10 times of incremental dilution methods, be diluted to 105～106cfu/ Ml, standby；

(3) the test bacterium solution that above-mentioned steps (2) prepares uniformly is inoculated on blood plate, left at room temperature 5min, will step Suddenly the 15 susceptibility sense sheets and the 5 blank sterilizing scraps of paper that prepare in (1) are laid on this blood plate, and flat board is inverted into cultivation In case after 37 DEG C of cultivation 24h, measure the antibacterial circle diameter (mm) of each susceptibility sheet, calculate the antibacterial circle diameter meansigma methods of each group, with Upper operation is sterile working.

5, experimental observation is measured:

Observe: represent with "-" without inhibition zone；

Antibacterial circle diameter ＜ 10mm is the most antibacterial, with "+" represent；

Antibacterial circle diameter 10～14mm is that moderate is antibacterial, represents with " ++ "；

Antibacterial circle diameter ＞ 14mm is that height is antibacterial, represents with " +++ "；

	Negative control	Experimental group A	Experimental group B	Experimental group C
					Inhibitory action	-	+++	++	+++

Test result indicate that, the toothpaste of the present invention has more significant fungistatic effect, can play preferable antibacterial bacteriostatic Effect.

The above, the only explanation embodiment of the present invention, not the present invention is appointed and formal and substantial restriction, It should be pointed out that, for those skilled in the art, on the premise of without departing from the inventive method, that makes some changes Enter and supplement and also should be regarded as protection scope of the present invention.All those skilled in the art, in the spirit without departing from the present invention In the case of scope, utilize a little change that disclosed above technology contents is made, the equivalent variations modified and develop, all Equivalent embodiments for the present invention；Meanwhile, what above-described embodiment was done by the substantial technological of all foundation present invention appoints and equivalent change Change change, modify and develop, all still fall within the scope of technical scheme.It is existing at the most detailed disclosure of the present invention Technology.

Claims (9)

1. a green lemon toothpaste, it is characterised in that raw material and the mass percent thereof of making described toothpaste be: Oleum Caryophylli 0.1- 0.3%, Oleum menthae 0.3-0.5%, glycerol 7-10%, silicon dioxide 35-40%, sodium lauryl sulphate 0.5-0.7%, whitening Agent 1-3%, fruit and vegerable extracting solution 10-15%, the concentrated liquid of tradition Chinese medicine 5-10%, surplus is distilled water；Make described fruit and vegerable extracting solution Raw material and parts by weight thereof are: green lemon 20-30 part, Herba Portulacae 10-15 part, Fructus Benincasae sarcocarp 10-15 part, Herba Lactucae versicoloris 6-10 part；System The raw material and the parts by weight thereof that become described the concentrated liquid of tradition Chinese medicine are: Radix Scutellariae 6-8 part, Flos Lonicerae 10-15 part, Radix Gentianae 3-5 part, Flos Chrysanthemi Indici 10-15 part, Herba Houttuyniae 8-12 part, Fructus Forsythiae 8-12 part, Cortex Magnoliae Officinalis 3-5 part, Rhizoma Cimicifugae 1-3 part, Galla Chinensis 6-9 part, Radix Paeoniae Alba 6-9 part is blue Eucalyptus globulus 7-10 part, Radix Glycyrrhizae Preparata 4-7 part.

2. green lemon toothpaste as claimed in claim 1, it is characterised in that described whitening agent be sodium phytate, aloin, One or more in glycyrrhizin and glucoseoxidase.

3. green lemon toothpaste as claimed in claim 2, it is characterised in that described whitening agent is aloin and glucoseoxidase Mixture, in whitening agent, the mass ratio of aloin and glucoseoxidase is 3:2.

4. green lemon toothpaste as claimed in claim 1, it is characterised in that described green lemon, Herba Portulacae, Fructus Benincasae sarcocarp, Herba Lactucae versicoloris Be cut into small pieces after Xi Jinging mixing, adds after the deionized water with the quality such as mixed material is squeezed the juice and stands 0.5h, crosses 200 mesh drainage screens Gained filtrate is described fruit and vegerable extracting solution.

5. green lemon toothpaste as claimed in claim 4, it is characterised in that make raw material and the weight thereof of described fruit and vegerable extracting solution Number is: green lemon 25 parts, Herba Portulacae 13 parts, Fructus Benincasae sarcocarp 12 parts, Herba Lactucae versicoloris 8 parts.

6. green lemon toothpaste as claimed in claim 1, it is characterised in that the preparation method of described the concentrated liquid of tradition Chinese medicine is: Radix Scutellariae, Flos Lonicerae, Radix Gentianae, Flos Chrysanthemi Indici, Herba Houttuyniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Rhizoma Cimicifugae, Galla Chinensis, the Radix Paeoniae Alba, Eucalyptus globulus Labill, Radix Glycyrrhizae Preparata co-grinding obtain 100 Mesh mixed-powder, gained mixed-powder adds water soaking 1h, the slow fire boiling 1h of gross mass multiple 5 times, crosses 200 mesh mistakes after decoction Filter screen obtains filtrate, and gained filtrate adds in low-temperature vacuum thickener after being cooled to room temperature, and cryoconcentration (less than 40 DEG C) is to relatively Density is the concentrated solution of 1.20 ± 0.02 (40 DEG C).

7. a kind of green lemon toothpaste as claimed in claim 6, it is characterised in that make raw material and the quality hundred thereof of described toothpaste Proportion by subtraction is: raw material and the parts by weight thereof of making described the concentrated liquid of tradition Chinese medicine are: Radix Scutellariae 7 parts, Flos Lonicerae 12 parts, Radix Gentianae 4 parts, Herba Dendranthematis indici Spend 12 parts, Herba Houttuyniae 10 parts, Fructus Forsythiae 10 parts, Cortex Magnoliae Officinalis 4 parts, Rhizoma Cimicifugae 2 parts, Galla Chinensis 7 parts, the Radix Paeoniae Alba 8 parts, Eucalyptus globulus Labill 9 parts, Radix Glycyrrhizae Preparata 5 Part.

8. green lemon toothpaste as claimed in claim 1, it is characterised in that make raw material and the mass percent thereof of described toothpaste For: Oleum Caryophylli 0.2%, Oleum menthae 0.4%, glycerol 8%, silicon dioxide 37%, sodium lauryl sulphate 0.6%, whitening agent 2%, fruit and vegerable extracting solution 13%, the concentrated liquid of tradition Chinese medicine 7%, distilled water 31.8%.

9. the preparation method of the green lemon toothpaste as according to any one of claim 1 to 8, it is characterised in that described preparation side Method is: by Oleum Caryophylli, Oleum menthae, glycerol, silicon dioxide, sodium lauryl sulphate, whitening agent, fruit and vegerable extracting solution, traditional Chinese drug inspissation Liquid and distilled water are weighed after getting the raw materials ready respectively, disperse, mix in pre-dispersed still, open cream still vacuum pump processed and suck above-mentioned liquid material, so After drive scraper, agitator and colloid mill, close colloid mill, agitator and scraper, vacuum breaker after 50 minutes successively, obtain green lemon Toothpaste.