JP2006347987A - Composition for oral cavity and method for enhancing foamability of composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for oral cavities, which foams in suitable volumes, enhances the sustainability of the produced foams, has reduced irritability, and gives excellent senses of use. <P>SOLUTION: This composition for oral cavities comprising xanthan gum, an alginate, an anionic surfactant and a nonionic surfactant, is characterized in that the content of the anionic surfactant is ≥1.7 mass% based on the total amount of the composition. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an oral composition having good foamability and excellent usability, and a method for increasing the foamability of the oral composition.

  Examples of oral compositions include toothpaste, liquid toothpaste, and mouthwash. These oral compositions may be added with binders such as alginates and xanthan gum in order to enhance the feeling of use and stability.

  For example, in the composition for oral cavity of patent document 1, sodium alginate and xanthan gum are used together, and these caking agents are said to increase the retention in the oral cavity of triclosan, which is a bactericide. Moreover, the composition for oral cavity of patent document 2 contains a xanthan gum, alginate, etc., The said composition does not have liquid separation but is said that stability is favorable.

  The composition for oral cavity described in Patent Document 3 also contains two or more binders in addition to the higher alcohol sulfate, and examples containing both alginate and xanthan gum are described. This composition for oral cavity is said to be excellent in high-temperature stability and good in use feeling such as “feeling of brushed teeth” and “texture of foam”. Although the composition for oral cavity of patent document 4 is a dentifrice composition with the high prevention and treatment effect of the periodontal disease which uses ascorbic acid etc. as an active ingredient, the Example containing both an alginate and a xanthan gum is described similarly. Yes.

In addition, the composition for oral cavity of patent document 5 contains halogenated diphenyl ethers, such as a triclosan, etc., and the Example containing both an alginate and a xanthan gum is described. This composition for oral cavity can suppress bacteria in the oral cavity for a long time and is said to have a good feeling of use, but since there was no other description on the feeling of use, the antibacterial property was enhanced. This is considered to be a feeling of use.
Japanese Patent Laid-Open No. 7-187975 (Claims, paragraph [0004], Examples) JP 11-71250 A (claims, paragraph [0001], examples) JP-A-11-180838 (Claim 1, paragraph [0001], Example 9) JP 2001-302476 A (paragraph [0001], Examples 7 and 9) JP 10-330230 A (paragraphs [0001], [0010], Examples 6 and 12)

  As described above, oral compositions containing both alginate and xanthan gum, which have been known for their feeling of use, have been known to have a moderate amount of foaming or to maintain the sustainability of the generated foam. None of the compositions were devised to improve the feeling of use. However, foaming at the time of use is very important in oral compositions such as toothpastes, liquid dentifrices, and mouthwashes. This is because a moderate amount of highly durable foam not only enhances the feeling of use but also has an effect of spreading the active ingredient throughout the oral cavity. In order to enhance this foaming property, it is necessary to add a surfactant, but on the other hand, it is also important to suppress stimulation by the surfactant.

  Therefore, the problem to be solved by the present invention is to provide a composition for oral cavity that has a moderate amount of foaming and has increased foam sustainability while being hypoallergenic and excellent in usability. .

  In order to solve the above-mentioned problems, the present inventors proceeded with studies on the component constitution of the oral composition. As a result, the inventors have found that the above problems can be solved by adding a relatively large amount of anionic surfactant and adding xanthan gum, sodium alginate or the like, and the present invention has been completed.

  That is, the oral composition of the present invention contains xanthan gum, alginate, an anionic surfactant and a nonionic surfactant, and the content of the anionic surfactant is 1.7% by mass or more based on the whole composition. It is characterized by being. In addition, "mass%" here means the ratio with respect to the whole composition, and it is the same also below.

  In the above composition, the contents of xanthan gum, alginate and nonionic surfactant, which are essential constituents other than the anionic surfactant, are 0.01 to 2% by mass, 0.01 to 2% by mass, and 0.002%, respectively. 3-2 mass% is suitable. This is because it is an amount that can satisfactorily exert the action and effect of each essential component such as the persistence of the generated foam and the reduction of irritation.

It is preferable to mix two or more anionic surfactants. Examples of the anionic surfactant include alkyl sulfate surfactants such as sodium lauryl sulfate, and sulfosuccinic acid such as sodium salt or magnesium salt of polyoxyethylene (0 to 7 mol) alkyl (C _10-16 ) sulfosuccinic acid. System surfactants, combinations thereof, and the like are suitable. An anionic surfactant is a very good additive component for controlling foaming, but if it is added excessively, there is a possibility that the irritation becomes strong. However, the above-mentioned anionic surfactant is very useful as a combination of other essential constituents and can suppress the irritation and moderate the amount of foaming to increase the sustainability of the generated foam. Moreover, the effect of these anionic surfactants is demonstrated by the below-mentioned Example.

  As the nonionic surfactant, a polyoxyethylene addition type surfactant is suitable. This is because the effect has been demonstrated in examples described later.

  As the composition for oral cavity, a composition further containing 0.1 to 1% by mass of sodium carboxymethylcellulose is preferable. It is because it is excellent as a component for further improving the sustainability of the foam.

  In addition, the method of the present invention is a method for enhancing the foaming property of an oral composition, wherein xanthan gum, alginate, an anionic surfactant and a nonionic surfactant are blended, and the blending amount of the anionic surfactant is 1 0.7 mass% or more.

  The oral composition of the present invention has a moderate foaming amount and a longer duration of the generated foam. That is, the foaming property is very good. In addition, the stimulation is reduced while having such excellent foamability. Therefore, the composition for oral cavity of the present invention is very useful as having excellent usability. In addition, the method of the present invention is useful as one that can improve the feeling of use by increasing the foamability of the oral composition.

  The oral composition of the present invention contains xanthan gum, alginate, an anionic surfactant and a nonionic surfactant, and the content of the anionic surfactant is 1.7% by mass or more based on the whole composition. It is characterized by.

  Xanthan gum, which is an essential component of the composition of the present invention, is a high-molecular polysaccharide produced by Xanthromonas campestrics outside the cell, and has a trisaccharide group consisting of one glucuronic acid and two mannoses in the side chain of the cellulose skeleton. It has a structure. Conventionally, it has been used mainly in foods and cosmetics as a stabilizer and thickener, and is safe. Although its molecular weight is said to be about 2 million, there are reports of 13 to 50 million. Since the molecular weight of the xanthan gum used can affect the viscosity and the like of the composition, xanthan gum corresponding to the properties of the target composition may be used as appropriate.

  0.01-2 mass% is suitable for the compounding quantity of the xanthan gum with respect to this invention composition. This is because if the amount is less than 0.01% by mass, the foam sustainability may not be sufficiently exhibited, whereas if it exceeds 2% by mass, the foaming property may be deteriorated. From such a viewpoint, 0.1 mass% or more is more preferable, 0.2 mass% or more is more preferable, 1.5 mass% or less is more preferable, and 1 mass% or less is further preferable.

  Alginate, which is an essential component of the composition of the present invention, is a salt of a linear molecule composed of β-1,4 bonds of mannuronic acid and guluronic acid, and is obtained using brown algae as a raw material. Conventionally, it is mainly used for food and cosmetics and is safe. Although its molecular weight is said to be about 2 million, it is thought to be due to molecular association, but there are reports of 13 to 50 million.

  The “alginate” may be a single salt or a mixture of two or more salts. Examples of the salt include sodium salt and potassium salt, and sodium salt is particularly preferable. Moreover, although a calcium salt or a magnesium salt may be used, a divalent metal salt may be in the form of a gel. In that case, the amount of divalent metal ions with respect to the carboxyl group of alginic acid is suppressed, or a monovalent metal What is necessary is just to mix salt.

  0.01-2 mass% is suitable for the compounding quantity of the alginate with respect to this invention composition. This is because if the amount is less than 0.01% by mass, the foam sustainability may not be sufficiently exhibited, whereas if it exceeds 2% by mass, the foaming property may be deteriorated. From such a viewpoint, 0.1 mass% or more is more preferable, 0.15 mass% or more is more preferable, 1.5 mass% or less is more preferable, and 1 mass% or less is further preferable.

  The type of the anionic surfactant that is an essential component of the present invention is not particularly limited as long as it is conventionally used for oral cavity. For example, the number of carbon atoms of an alkyl group such as sodium lauryl sulfate, sodium myristyl sulfate, etc. A higher alkyl sulfate salt having a salt of 8 to 18; a sulfosuccinic acid surfactant; an N-acyl sarcosine sodium such as sodium N-lauroyl sarcosine and sodium N-myristoyl sarcosine; an N-long chain acyl amino acid salt; an α-olefin sulfonate Higher fatty acid sodium monoglyceride monosulfate; N-methyl-N-palmitoyl tauride salt; N-acyl glutamate; N-methyl-N-acyl taurine sodium; N-methyl-N-acylalanine sodium; α-olefin sulfone Acid sodium Can be mentioned.

  Of the above anionic surfactants, sulfosuccinic surfactants are a kind of anionic surfactant and are derivatives of sulfosuccinic acid having a sulfonic acid group substituted at the second position of succinic acid. Examples of such sulfosuccinic acid-based surfactants include those having the following chemical structure (I) (hereinafter referred to as “sulfosuccinic acid-based surfactant (I)”).

[In the formula, ^one of X ¹ and X ² represents R ¹ O— (AO) n — or R ¹ CO—B— (AO) n —, and the other represents M ² O—, where M ¹ and M ² are the same or different and each represents hydrogen, alkali metal, alkaline earth metal, ammonium or alkanolamine, R ¹ represents an alkyl group or alkenyl group having 8 to 22 carbon atoms, and AO represents 2 carbon atoms. An oxyalkylene group of ˜3, the average added mole number n is 0-20, and B is —NH— or a monoalkanolamine residue of 2 to 3 carbon atoms].

In the sulfosuccinic acid surfactant (I), R ¹ is a linear or branched alkyl group or alkenyl group having about 8 to 22 carbon atoms, which is naturally derived or synthesized. Examples thereof include lauryl, cocoyl, myristyl, stearyl, C _12-14 synthetic alkyl, isononyl, isododecyl, octenyl, dodecenyl and the like. Although the bitterness and irritation are reduced as the carbon number of R ¹ is longer, the effect of inhibiting the formation of stain becomes higher as the carbon number is shorter, so the carbon number of R ¹ is preferably about 10 to 16, more preferably about 12 to 14. In particular, C _12-14 synthetic alkyl or lauryl and myristyl are most preferably used in combination.

Examples of the alkali metal in the definitions of M ¹ and M ² include sodium and potassium. Examples of the alkaline earth metal include magnesium, and examples of the alkanolamine include monoethanolamine, diethanolamine, and triethanolamine. Among these, as M ¹ and M ² , sodium and magnesium are more preferable, and sodium is particularly preferable.

  As the AO group, an oxyethylene group is preferred. The average added mole number n of AO is preferably about 0 to 7, and most preferably about 0 to 2. Here, the average number of added moles of 0 means a sulfosuccinic acid monoester to which no oxyalkylene is added.

As a preferred sulfosuccinic acid type surfactant (I), R ¹ is an alkyl group having about 12 to 14 carbon atoms, AO group is an oxyethylene group, and its average added mole number n is about 0 to 2. Sodium salt. Specifically, polyoxyethylene (2 mol) alkyl (C _12-14 ) sulfosuccinic acid disodium, polyoxyethylene (1 mol) alkyl (C _12-14 ) sulfosuccinic acid disodium, alkyl (C _12-14 ) Examples include disodium sulfosuccinate. In the present invention, for example, even when the average added mole number of oxyethylene groups is 0 to 2, it is included in “polyoxyethylene”.

Specific examples of the sulfosuccinic surfactant include polyoxyethylene (7 mol) lauryl sulfosuccinate disodium, polyoxyethylene (2 mol) lauryl sulfosuccinate disodium, polyoxyethylene (1 mol) lauryl sulfosuccinic acid. Disodium, disodium lauryl sulfosuccinate, disodium polyoxyethylene (7 mol) myristyl sulfosuccinate, polyoxyethylene (2 mol) alkyl (C _12-14 ) disodium sulfosuccinate, polyoxyethylene (1 mol) alkyl ( _C12-14 ) disodium sulfosuccinate, alkyl ( _C12-14 ) disodium sulfosuccinate, polyoxyethylene (2 mol) magnesium lauryl sulfosuccinate, polyoxyethylene (2 mol) alkyl ( _C12-14 ) sulfosuccinic acid Mug Nesium, polyoxyethylene (7 mol) myristyl sulfosuccinic acid 2 triethanolamine, oleic acid amide sulfosuccinic acid disodium salt, polyoxyethylene (5 mol) lauroylethanolamide sulfosuccinic acid disodium salt, polyoxyethylene (2 mol) cocoyl isopropanolamide Examples include disodium sulfosuccinate.

The sulfosuccinic surfactants may be used alone or in combination of two or more. For example, in sulfosuccinate surfactant (I), in the case the number of carbon atoms in R ¹ is 12 to 14, may be a number of carbon atoms of R ¹ is 12 single sulfosuccinate surfactant, of R ¹ It may be a mixture of three types of sulfosuccinic surfactants having 12, 13, and 14 carbon atoms.

  The anionic surfactant for the composition of the present invention is 1.7% by mass or more. This is because if the amount is less than 1.7% by mass, the effect of improving the amount of foaming and the sustainability of the generated foam may not be exhibited. On the other hand, if the amount is too large, the irritation may be strong, so the content is preferably 5% by mass or less.

  As the anionic surfactant, a higher alkyl sulfate salt is preferable, and among them, sodium lauryl sulfate is preferable.

In the present invention, it is preferable to use a combination of two or more anionic surfactants. This is because the stimulation can be reduced while improving the sustainability of the generated foam by making the amount of foaming moderate. As a combination of two or more, for example, an alkyl sulfate surfactant such as sodium lauryl sulfate and a sodium salt or magnesium salt of polyoxyethylene (0 to 7 mol) alkyl (C _10-16 ) sulfosuccinic acid A combination with a sulfosuccinic acid surfactant can be mentioned.

The type of the nonionic surfactant that is an essential component of the present invention is not particularly limited as long as it is conventionally used for oral cavity. For example, polyoxyethylene sorbitan such as polyoxyethylene sorbitan monolaurate is used. Polyoxyethylene fatty acid ester such as fatty acid ester, polyoxyethylene hydrogenated castor oil, lauric acid monoethanolamide, myristic acid monoethanolamide, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene poly Oxypropylene fatty acid ester alkyl glycoside (for example, alkyl chain: about C _8-16 ), polyglycerol fatty acid ester (for example, alkyl chain of fatty acid portion: about C _8-16 ), sucrose fatty acid ester (for example, alkyl chain of fatty acid portion: C _8-16 degree ), And the like. Among these, polyoxyethylene addition type surfactants are preferred, and polyoxyethylene addition selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene sorbitan fatty acid ester A type of surfactant is more preferred.

  The blending amount of the nonionic surfactant with respect to the composition of the present invention is preferably 0.3 to 2% by mass. If the amount is less than 0.3% by mass, the effect of improving the foaming property may not be exhibited. On the other hand, if it exceeds 2% by mass, the foaming property may be deteriorated.

  In addition to the above essential components, sodium carboxymethylcellulose is preferably added as a binder to the oral composition of the present invention. This is because the durability of the foam is further improved. Moreover, 0.1-1 mass% is suitable for the compounding quantity. If the amount is less than 0.1% by mass, the effect of improving the sustainability of the foam may not be sufficiently exhibited. If the amount exceeds 1% by mass, the viscosity of the composition may increase and the feeling of use may be deteriorated. .

  The oral composition of the present invention can be formulated into powdered toothpaste, toothpaste, gel, profi paste, pasta, liquid toothpaste, mouthwash, chewing gum, dental floss, patch, sealant, tablet and the like by conventional methods. From the viewpoint of usability, a dentifrice, a liquid dentifrice or a mouthwash is particularly preferred.

  In the composition for oral cavity of the present invention, water, lower alcohol, higher alcohol and additives usually used in the field can be appropriately blended in addition to the above essential components depending on the dosage form. Examples of such additives include abrasives, excipients, foaming agents, fragrances, sweeteners, binders, pH adjusters, wetting agents, preservatives, colorants, various medicinal ingredients, and the like. It can mix | blend in the range which is not impaired.

  Although the compounding quantity of water can be suitably set according to a dosage form etc., it is about 0-90 mass% normally with respect to the whole composition, Preferably it is about 10-85 mass%. The compounding quantity of a lower alcohol is about 0-20 mass% normally with respect to the whole composition, Preferably it is about 0-10%. The compounding quantity of a higher alcohol is about 0-70 mass% normally with respect to the whole composition, Preferably it is about 5-50 mass%.

  When the composition of the present invention is used as a dentifrice, dibasic calcium phosphate dihydrate and anhydrous, calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silica gel, aluminum silicate Precipitating silica, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin, and the like can be used. These abrasives may be used alone or in combination of two or more, and the blending amount is usually about 5 to 90% by mass with respect to the whole composition, and 5 to 50% in the case of toothpaste. %.

  Examples of the excipient include igneous silica, thickened silica (generally showing silica having an RDA value of about 30 or less), powdered cellulose such as crystalline cellulose, and the like. Of these, ignitable silica and thickened silica are preferred. The compounding quantity of an excipient | filler is about 0.1-30 mass% normally with respect to the whole composition, Preferably it is about 0.5-10 mass%.

In addition to the surfactant that is an essential component of the present invention, an amphoteric surfactant and a cationic surfactant that are usually used in oral compositions may be blended. Examples of such a surfactant include N-alkyldiaminoethylglycine, alkylbetaine, fatty acid amidopropylbetaine (for example, alkyl chain of fatty acid moiety: about C _8-16 ), alkylsulfobetaine, alkylbetaine, imidazolinium. Examples include amphoteric surfactants such as betaine; cationic surfactants such as alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, and alkyldimethylammonium chloride.

  The compounding amount of the surfactant excluding the anionic surfactant and the nonionic surfactant which are essential components is usually about 0.001 to 5% by mass, preferably 0.01 to 2% by mass with respect to the whole composition. %.

  Examples of the binder include cellulose derivatives such as sodium carboxymethiscellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose; propylene glycol alginate; gums such as tragacanth gum, karaya gum, gum arabic, carrageenan; polyvinyl alcohol, sodium polyacrylate, carboxy Synthetic binders such as vinyl polymer and polyvinyl pyrrolidone are listed. A binder may be used independently or may use 2 or more types together. The compounding quantity is about 0.3-5 mass% normally with respect to the whole composition.

  As a fragrance, vanillin, anethole, benzyl succinate, menthol, carvone, eugenol, methyl salicylate, limonene, osimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineol, linalool, Examples include ethyl linalool, crocodile and thymol. These may be used as single product compounds, but may be blended as plant extracts such as essential oils containing them. Such plant extract fragrances include thyme oil, nutmeg oil, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla oil, winter green Oil, eucalyptus oil, basil oil, tea tree oil, tabana oil and the like. A fragrance | flavor may be used independently or may use 2 or more types together. The compounding quantity of a fragrance | flavor is about 0.05-10 mass% normally with respect to the whole composition, Preferably it is about 0.1-5 mass%.

  Examples of the sweetener include saccharin sodium, trehalose, stevioside, acesulfame K, glycyrrhizin or a salt thereof, perilartin, thaumatin, aspartylphenylalanine methyl ester, xylitol, palatinose, palatinit, erythritol, maltitol and the like. Sweetening agents may be used alone or in combination of two or more. The compounding quantity of a sweetener is about 0.01-5 mass% normally with respect to the whole composition.

  Examples of the wetting agent include sorbite liquid, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, lactit and the like. A wetting agent may be used independently or may use 2 or more types together, and the compounding quantity is about 5-70 mass% normally with respect to the whole composition.

  Examples of pH adjusters include phosphoric acid and its salts (sodium phosphate, sodium hydrogen phosphate, etc.), citric acid and its salts (sodium salt, etc.), phosphoric acid and its salts, malic acid and its salts, gluconic acid And salts thereof, maleic acid and salts thereof, aspartic acid and salts thereof, gluconic acid and salts thereof, succinic acid and salts thereof, glucuronic acid and salts thereof, fumaric acid and salts thereof, glutamic acid and salts thereof, adipic acid and salts thereof , Hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium silicate, and the like. A pH adjuster may be used independently or may use 2 or more types together. Although the compounding quantity of a pH adjuster will not be restrict | limited especially as long as it becomes desired pH, It is about 0.01-5 mass% normally with respect to the whole composition, Preferably it is about 0.1-3 mass%. The pH of the composition of the present invention is not particularly limited as long as the effect of the present invention is exerted, but is usually about 4 to 10, and preferably about 5.5 to 9.

  Examples of preservatives include benzoates such as sodium benzoate; parabens such as methylparaben and butylparaben. A preservative may be used independently or may use 2 or more types together. The compounding amount of the preservative is usually about 0.01 to 3% by mass with respect to the whole composition.

  Examples of the colorant include legal dyes such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3; mineral dyes such as ultramarine blue, enhanced ultramarine blue, and bitumen; and titanium oxide. A colorant may be used independently or may use 2 or more types together. The compounding quantity of a coloring agent is about 0.0001-1 mass% normally with respect to the whole composition.

  Examples of medicinal ingredients include cetylpyridinium chloride, benzethonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, quaternary ammonium salts such as laurylpyridinium chloride, chlorhexidine hydrochloride, Cationic fungicides such as biguanide fungicides such as chlorhexidine acetate, chlorhexidine gluconate, alexidine hydrochloride, alexidine acetate, alexidine gluconate; anionic fungicides such as sodium n-lauroyl sarcosine; triclosan, isopropylmethylphenol, thymol, hinokitiol Nonionic fungicides such as dextranase, amylase, papain, protease, mutanase, Enzymes such as teams, lytic enzymes (Litec Enzymes); zinc compounds such as zinc oxide and zinc chloride; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, sodium fluoride, stannous fluoride , Fluorides such as silver fluorinated diamine, tea and extracts thereof, seaweed and extracts thereof; vitamin E derivatives such as tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholesterol, tocopherol acetate; other glycyrrhizin salts, Examples thereof include glycyrrhetinic acid, glycerophosphate, chlorophyll, potassium nitrate, sodium chloride, caropeptide, and a water-soluble inorganic phosphate compound.

As a water-soluble inorganic phosphate compound,
Formula (II): M _{m + 2} P _m O _{3m + 1}
[Wherein M represents sodium or potassium, m is an integer of 2 or more], and general formula (III): (MPO ₃ ) _q
[In the formula, M represents sodium or potassium, and q is an integer of 3 or more.]
The compound represented by these can be illustrated.

  m is an integer of 2 or more, preferably an integer of about 2-6. q is usually an integer of 3 or more, preferably an integer of about 3 to 6.

  Specific examples of the compound represented by the general formula (II) include sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate and the like.

  Specific examples of the compound represented by the general formula (III) include sodium tetrametaphosphate and sodium hexametaphosphate.

  An active ingredient may be used independently or may use 2 or more types together. The blending amount of the active ingredient is not particularly limited as long as the desired effect is obtained, and can be appropriately set according to the type of the active ingredient. The compounding quantity of an active ingredient is about 0.001-30 mass% normally with respect to the whole composition, Preferably it is about 0.01-20 mass%.

  The manufacturing method of this invention composition should just use the conventional method according to a dosage form, and is not specifically limited. For example, xanthan gum and alginate may be dispersed in a polyhydric alcohol solvent such as glycerin, dissolved by adding water, and further kneaded until other additive components are added and dissolved or uniformly dispersed. In addition, if it is a manufacturing condition from which a formulation becomes favorable, it can be employ | adopted.

  In addition, the method of the present invention is a method for enhancing the foaming property of an oral composition, wherein xanthan gum, alginate, an anionic surfactant and a nonionic surfactant are blended, and the blending amount of the anionic surfactant is 1 0.7 mass% or more. By blending these ingredients into the oral composition, the foaming amount of the composition can be moderated to increase the sustainability of the generated foam, while the irritation can be reduced and as a result, the feeling of use can be improved. It becomes.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited by the following examples, but may be appropriately modified within a range that can meet the purpose described above and below. It is also possible to implement, and they are all included in the technical scope of the present invention.

Example 1 Foaming property test The ingredients shown in Table 1 (values in Table 1 are% by mass), ethanol 0.9% by mass, sodium saccharin 0.1% by weight as a sweetener, and peppermint oil 0.1% by weight as a flavoring agent % Was added to distilled water for dissolution, and further distilled water was added to dilute it four times to prepare compositions (Nos. 1 to 17). 10 mL of this composition was put into a 50 mL female lidar with a lid, and stirred for 1 minute by a vortex mixer, and the composition was foamed and allowed to stand. Immediately thereafter, the memory at the uppermost end of the foam was read after 5 minutes, 15 minutes, 20 minutes, and 30 minutes. The results are shown in Table 2. Further, Table 3 shows the change of the numerical value. The surfactants and abbreviations used in Table 1 are as follows.

Anionic surfactant 1: Sodium lauryl sulfate Anionic surfactant 2: Polyoxyethylene (2 mol) alkyl (C _12-14 ) Disodium sulfosuccinate Anionic surfactant 3: n-lauroyl sarcosine sodium Nonionic surfactant 1 : POE (60) hydrogenated castor oil non-ionic surfactant 2: lauric acid diethanolamide nonionic surfactant 3: monoethanolamide CMC ones of the center of the coconut oil fatty acid C _12: carboxymethylcellulose sodium

  As the result, even when only one kind of anionic surfactant is contained (Composition No. 5, 6, 8), or even when two or more kinds of anionic surfactant are contained, the total is 1.7 mass. When it is less than% (Nos. 1 and 2), foaming is not sufficient, or the persistence of the foam is not sufficient. In addition, the composition containing no xanthan gum (No. 3), the one containing no alginate (No. 4), and the one containing no nonionic surfactant (No. 7) have good foaming, but persistence. Is not enough.

  On the other hand, the composition (Nos. 9 to 17) included in the scope of the present invention has good foaming and sufficient sustainability of the generated foam. Therefore, the excellent foaming property of the present invention was demonstrated.

Example 2 Sensory test Each composition prepared in Example 1 above was put in the mouth of a total of 3 adults, 2 adult men and 1 adult woman. Almost no stimulation, 3: Slight stimulation, 4: Strong stimulation, 5: Very strong stimulation. The results are shown in Table 4.

  From the results, it was revealed that the composition of the present invention has a relatively low irritation and there is nothing that cannot be used. In particular, composition no. The foaming properties of 9 and 12 to 15 were good and there was little irritation.

Example 3 Foaming property test The composition No. 18 and 19 were prepared. As the POE alkyl sulfosuccinate Na, polyoxyethylene (2 mol) alkyl (C _12-14 ) sulfosuccinate disodium was used.

  The composition No. 300 ml of each of 18 and 19 was diluted 4-fold with distilled water, and a foaming tester (a cylindrical container having an inner diameter of about 11 cm and a height of about 20 cm, a net having a diameter of 5 cm concentric with the container, a central stirring blade, and It consists of a foam height sensor, and it is put into a device that can create foam by rotating the stirring blades and measure the height of the foam with the sensor) and stirred at 1500 rpm for 5 minutes while keeping the temperature of each composition at 40 ° C. Bubbling. The height and time of the foam at that time were set to 0, and the height (unit: mm) of the foam after 1 minute, 5 minutes, 10 minutes, 15 minutes, 20 minutes, and 30 minutes was measured. The difference from the bubble height at time 0 was determined. The results are shown in FIG. 1 as an average value for each three cases.

  According to the result, composition No. containing no xanthan gum and alginate was used. Since the bubble height of 19 decreased with time, it can be said that the bubble persistence is low. On the other hand, No. which is the composition of the present invention. In No. 18, the bubble height once decreased after the stirring was stopped, but thereafter the bubble height was increased. Thus, it was demonstrated that the composition of the present invention has excellent foam persistence.

Example 4 Dentifrice Xanthan gum 0.4% by mass
Sodium alginate 0.4% by mass
POE (7 mol) myristyl sulfosuccinic acid 2Na 0.7 mass%
Sodium myristyl sulfate 1.3% by mass
POE (20) hydrogenated castor oil 0.5% by mass
Sodium carboxymethyl cellulose 0.4% by mass
Glycerin 10% by mass
Sorbit liquid (70%) 20% by mass
Calcium hydrogen phosphate, anhydrous 30% by mass
Calcium hydrogen phosphate dihydrate 5.0% by mass
Thickening silica 5.0% by mass
Titanium oxide 0.2% by mass
Saccharin sodium 0.1% by mass
Benzethonium chloride 0.1% by mass
Sodium benzoate 0.5% by mass
Methylparaben 0.2% by mass
Fragrance 1.0% by mass
Water, etc.

Example 5 Dentifrice Xanthan gum 0.5% by mass
Sodium alginate 0.2% by mass
Carrageenan 0.1% by mass
Sodium lauryl sulfosuccinate 0.5% by mass
Sodium lauryl sulfate 1.0 mass%
n-Lauroyl sarcosine sodium 0.5 mass%
POE (80) hydrogenated castor oil 0.7% by mass
Sodium carboxymethyl cellulose 0.3% by mass
Sorbit liquid (70%) 20% by mass
Calcium carbonate 40% by mass
Saccharin sodium 0.1% by mass
Xylitol 5.0% by mass
Trehalose 5.0% by mass
Aminocaproic acid 0.1% by mass
Fragrance 1.0% by mass
Water, etc.

Example 6 Dentifrice (without abrasive)
Xanthan gum 0.8% by mass
Sodium alginate 0.5% by mass
POE (2 mol) alkyl (C _12-14 ) sodium sulfosuccinate 1.0% by mass
Sodium lauryl sulfate 1.0 mass%
POE (5) stearyl ether 0.5% by mass
Sodium carboxymethylcellulose 0.5% by mass
Sorbit liquid (70%) 50% by mass
Polyethylene glycol 400 5.0% by mass
Saccharin sodium 0.1% by mass
Palatinit 10% by mass
Sodium fluoride 0.2% by mass
Isopropyl methylphenol 0.1% by mass
Fragrance 1.0% by mass
Water, etc.

Example 7 Mouthwash Xanthan gum 0.2% by mass
Sodium alginate 0.15% by mass
POE (5 mol) palmitylsulfosuccinic acid 2Na 0.7% by mass
Sodium lauryl sulfosuccinate 0.5% by mass
Sodium lauryl sulfate 0.5% by mass
POE (40) hydrogenated castor oil 1.0% by mass
Glycerin 20% by mass
Propylene glycol 5.0% by mass
Ethanol 10% by mass
Saccharin sodium 0.01% by mass
Triclosan 0.1% by mass
Tocopherol acetate 0.1% by mass
Butylparaben 0.01% by mass
Methylparaben 0.1% by mass
Water, etc.

Example 8 Dentifrice Xanthan gum 0.3% by mass
Sodium alginate 0.5% by mass
Sodium lauryl sulfate 1.0 mass%
n-Lauroyl sarcosine sodium 1.0 mass%
POE (60) hydrogenated castor oil 0.7% by mass
Sodium carboxymethyl cellulose 0.4% by mass
Sorbit liquid (70%) 30% by mass
Aluminum hydroxide 30% by mass
Calcium hydrogen phosphate, anhydrous 10% by mass
Thickening silica 7.0% by mass
Saccharin sodium 0.1% by mass
Tocopherol acetate 0.1% by mass
Fragrance 1.0% by mass
Water, etc.

It is a figure which shows the sustainability of the foam by the composition for oral cavity of this invention. (B) shows the average value of each measured value, and (A) is a line graph of the average value. It has been demonstrated that the composition of the present invention exhibits excellent foam persistence, whereas the effect of the conventional composition reduces the foaming amount over time.

Claims (10)

  A composition for oral cavity comprising xanthan gum, alginate, an anionic surfactant and a nonionic surfactant, wherein the content of the anionic surfactant is 1.7% by mass or more based on the whole composition.   The composition for oral cavity according to claim 1, wherein the contents of xanthan gum, alginate and nonionic surfactant are 0.01 to 2% by mass, 0.01 to 2% by mass and 0.3 to 2% by mass, respectively. object.   The composition for oral cavity of Claim 1 or 2 containing 2 or more types of anionic surfactant.   The composition for oral cavity in any one of Claims 1-3 containing an alkyl sulfate type | system | group surfactant as an anionic surfactant.   The oral composition according to claim 4, wherein the alkyl sulfate surfactant is sodium lauryl sulfate.   The oral composition according to any one of claims 1 to 5, wherein the nonionic surfactant is a polyoxyethylene addition type surfactant.   The composition for oral cavity in any one of Claims 1-6 containing a sulfosuccinic-acid type surfactant as an anionic surfactant. The oral composition according to claim 7, wherein the sulfosuccinic acid surfactant is a sodium or magnesium salt of polyoxyethylene (0 to 7 mol) alkyl (C _10-16 ) sulfosuccinic acid.   Furthermore, the composition for oral cavity in any one of Claims 1-8 containing 0.1-1 mass% of carboxymethylcellulose sodium.   A method for enhancing foamability of an oral composition by blending xanthan gum, alginate, an anionic surfactant and a nonionic surfactant, and adjusting the blending amount of the anionic surfactant to 1.7% by mass or more.

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