JP2015117215A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition which has a high intraoral retentivity of fluorine ion and a good usability at the time of use.SOLUTION: The invention provides a dentifrice composition containing (A) sodium fluoride, (B) a hydroxyethyl cellulose dimethyldiallylammonium salt, (C) polyoxyethylene hardened castor oil in which an average addition mole number of ethylene oxide is 10-30 mol, and (D) polyoxyethylene alkyl ether in which a carbon number of an alkyl group is 12-18 and an average mole number of ethylene oxide is 3-8, wherein the ratio of component (D)/(C) is 0.1-0.42, the dentifrice oral composition contains 0.9-2.0 mass% of component (C), and 0.1-0.7 mass% of component (D).

Description

  The present invention relates to a dentifrice composition with enhanced oral retention of fluorine, comprising sodium fluoride, hydroxyethylcellulose dimethyl diallylammonium salt, and two nonionic surfactants in a specific ratio.

Fluorine compounds such as sodium fluoride have been widely used in dentifrice compositions as an active ingredient having an effect of suppressing the development of dental caries and promoting the remineralization of teeth.
In order for fluorine compounds to effectively act on teeth, it is important to allow low-concentration fluorine ions to act on teeth regularly and for a long time, and it is considered effective to use a dentifrice containing fluorine compounds. It is done. However, since the dentifrice is washed away by rinsing after brushing, the amount of fluorine ions remaining in the oral cavity is only a very small amount, and usually the caries prevention effect may not be sufficiently exerted.

  Therefore, it is an important problem to keep the fluorine ions in the oral cavity in order to effectively cause the fluorine compound to act on the teeth in the dentifrice. As means for improving the retention of fluorine ions, a technique using hydroxyethyl cellulose dimethyl diallylammonium salt which is a kind of cationic polymer (Patent Document 1, Patent Document 2 and Patent Document 3) is known.

JP 2001-163743 A JP 2007-320894 A Japanese Patent No. 4899951

However, the effect is not always sufficient, and in the composition having a large amount of nonionic surfactant as in Patent Document 3, the oral cavity becomes sticky during use, the number of times of rinsing after dentifrice increases, and fluoride ions enter the oral cavity. There is a risk of lowering the persistence.
In view of the above problems, it has been desired to develop an oral composition having high retention of fluorine ions in the oral cavity and good usability during use.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a composition for oral cavity that has high retention of fluorine ions in the oral cavity and has no stickiness during use and good usability.

  As a result of intensive studies to achieve the above object, the inventors of the present invention have (A) sodium fluoride, (B) hydroxyethylcellulose dimethyl diallylammonium salt, and (C) an average addition mole number of ethylene oxide of 10 to 30 mol. Polyoxyethylene hydrogenated castor oil, and (D) a polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average ethylene oxide mole number of 3 to 8, and components (C) and (D). It was found that by using a specific ratio, the retention of fluorine ions in the oral cavity was high and stickiness during use was suppressed, and the present invention was completed.

The present invention provides the following inventions.
[1] (A) Sodium fluoride,
(B) hydroxyethylcellulose dimethyl diallylammonium salt,
(C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 10 to 30 moles,
(D) It contains a polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average ethylene oxide addition mole number of 3 to 8, and a ratio of component (D) / (C) is 0.1 to 0. The dentifrice composition [2] (C) component is 0.9 to 2.0% by mass, and the component (D) is 0.1 to 0.7% by mass. The dentifrice composition according to claim 1.

  By setting it as the said structure of this invention, it can be set as the favorable dentifrice which was excellent in the retention of a fluorine ion to the tooth | gear, and the stickiness in the oral cavity in use was suppressed.

  The dentifrice composition of the present invention contains components (A) to (D) as essential components. Hereinafter, components (A) to (D) will be described in detail.

  Component (A) is sodium fluoride, and the blending amount thereof is preferably 100 ppm or more as fluorine in the composition, more preferably 300 ppm or more, and further preferably 500 ppm or more. Thereby, the caries prevention effect is exhibited effectively. Further, the upper limit is preferably 3000 ppm or less as fluorine, more preferably 1500 ppm or less, and further preferably 1000 ppm or less. The amount of component (A) is preferably 100 to 3000 ppm, more preferably 300 to 1500 ppm, and even more preferably 500 to 1000 ppm.

  Component (B) is hydroxyethylcellulose dimethyl diallylammonium salt. The counter ion includes chloride ion, and hydroxyethyl cellulose dimethyl diallylammonium chloride can be preferably used. The hydroxyethylcellulose dimethyl diallylammonium salt used in the present invention has a 2% by weight aqueous solution viscosity (BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute) of 30 to 3,000 mPa · s. It is preferable that it is 35-350 mPa * s. Moreover, it is preferable that nitrogen content is 0.1-3 mass%, More preferably, it is 0.5-2.5 mass%. The weight average molecular weight of the hydroxyethyl cellulose dimethyl diallylammonium salt of the present invention is not particularly limited, but is preferably a weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance, preferably 250,000 to 1,500. , 000. As such hydroxyethyl cellulose dimethyl diallylammonium salt, Cellcoat L-200 (2% by mass viscosity: 35 to 350 mPa · s, BH Brookfield viscometer, rotor No. 2, commercially available from Nippon SC Co., Ltd., 20 rotations, 20 ° C., measurement time 1 minute, weight average molecular weight by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance: 250,000-350,000, cell coat H-100 (2 mass% viscosity) : 500-2,750 mPa · s, BH type Brookfield viscometer, rotor No. 2, 20 revolutions, 20 ° C., measurement time 1 minute, weight by gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance Average molecular weight: 1,300, 00～1,500,000), and the like. Among these, Cellcoat L-200 is preferable from the viewpoint of plaque removal power and liquid dripping from the mouth.

  The compounding amount of component (B) is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, and further preferably 0.02% by mass or more in the composition. . As a result, the fluorine ion retention, retention persistence, and liquid separation stability are particularly excellent. The upper limit of the amount of component (B) is preferably 1% by mass or less, more preferably 0.5% by mass or less, and 0.3% by mass in the composition in terms of dispersibility and taste. More preferably, it is% or less. The amount of component (B) is preferably 0.005 to 1% by mass, more preferably 0.01 to 0.5% by mass, and 0.02 to 0.3% by mass. Is more preferable.

  Component (C) is polyoxyethylene hydrogenated castor oil. From the viewpoint of fluorine ion retention and stickiness suppression, ethylene oxide having an average added mole number of 10 to 30 is used, and 20 is particularly preferable. As such polyoxyethylene hydrogenated castor oil, for example, HCO-10, HCO-20, HCO-30 from Nikko Chemicals Co., Ltd., HC-10, HC-20, HC-30 from Nippon Emulsion Co., Ltd., Aoki Yushi Kogyo Co., Ltd. BLAUNONRCW-20 (polyoxyethylene addition mole number 20) of a company etc. are mentioned.

  The blending amount of the polyoxyethylene hydrogenated castor oil is 0.9 to 2.0% by mass, particularly preferably 1.0 to 1% in the dentifrice composition from the viewpoint of fluorine ion retention and stickiness suppression during use. 0.8% by mass.

  Component (D) is a polyoxyethylene alkyl ether, and from the viewpoint of fluorine ion retention and stickiness suppression, those having an average added mole number of ethylene oxide of 3 to 8, preferably 3 to 5 moles are used. is there.

  Further, as the carbon chain of the alkyl group of the polyoxyethylene alkyl ether, those having 12 to 18 carbon atoms are used, preferably 16 to 18 carbon atoms, from the viewpoint of retention of fluorine ions in the teeth and suppression of stickiness. Is.

  A commercial item can be used as such a polyoxyethylene alkyl ether. Examples of commercially available products include Emulex 103, Emarex 105, Emarex 107, Emarex 603, Emarex 605, Emarex 606, and Emarex 608 from Nippon Emulsion Co., Ltd. (hereinafter “product name”).

  In the dentifrice composition of the present invention, the mass ratio of component (D) to component (C) (component (D) / component (C)) is 0.1 or more, preferably 0.2 or more. . Thereby, the retention of fluorine ions is particularly good. Further, the component (D) / component (C) is 0.42 or less, and more preferably 0.35 or less. Thereby, the retention of fluorine ions and the sticking suppression effect during use are particularly good. Component (D) / component (C) is 0.1 to 0.42, preferably 0.2 to 0.35.

  The moisture content of the dentifrice composition is preferably 45% by mass or more, more preferably 48% by mass or more, and still more preferably 53% by mass or more in the composition. The upper limit of the moisture content is not particularly limited, but is usually 80% by mass or less.

  The dosage form of the dentifrice composition of the present invention is not particularly limited, and examples thereof include powder toothpaste, moistened toothpaste, toothpaste, liquid toothpaste, liquid toothpaste and gel toothpaste, preferably toothpaste, liquid toothpaste and liquid. It is toothpaste and gel-like toothpaste.

    In the dentifrice composition of the present invention, various other components that are acceptable for dentifrices, such as abrasives, binders, surfactants, thickeners, fragrances, as long as the effects of the present invention are not impaired. Sweetening agents, coloring agents, preservatives, various drugs, and the like can be blended.

Examples of the abrasive include the following: silica-based abrasives such as silicic anhydride, precipitated silica, silica gel, aluminosilicate, zirconosilicate, aluminum silicate, titanium bonded silicate; dicalcium phosphate 2 Hydrate and anhydrous, calcium phosphate-based abrasives such as monocalcium phosphate, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate; calcium carbonate, calcium hydroxide, calcium sulfate, aluminum hydroxide , Inorganic abrasives such as alumina, magnesium carbonate, tribasic magnesium phosphate, titanium dioxide, zeolite, bentonite, hydroxyapatite, fluoroapatite, calcium deficient apatite; polymethyl methacrylate, -Crystalline synthetic resins such as cellulose, semi-synthetic resin or natural organic abrasives like. Among these, preferred abrasives are silica-based abrasives.

  5-60 mass% is preferable in a composition, and, as for the compounding quantity in the case of mix | blending an abrasive | polishing agent, 8-50 mass% is more preferable especially.

  Examples of the binder include the following: cellulose derivatives such as sodium carboxymethylcellulose, sodium hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, methylcellulose; carrageenan, guar gum, tragacanth gum, karaya gum, arabic gum, Polysaccharides such as locust bean gum and sodium alginate; synthetic resins such as polyvinyl alcohol and carboxyvinyl polymer; inorganic substances such as silica gel, laponite and aluminum silica gel; clay minerals such as montmorillonite and beegum. The binder may be one type or a combination of two or more types.

  It is preferable that the compounding quantity in the case of mix | blending a binder is 0.2-3 mass% in a composition.

  Examples of optional surfactants other than the components (C) and (D) of the present invention include amphoteric surfactants, anionic surfactants, nonionic surfactants, and amphoteric surfactants.

  Examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; acyl sarcosine salts such as sodium lauroyl sarcosine and sodium myristoyl sarcosine; sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate N-acyl glutamate such as sodium lauryl sulfoacetate and sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate and the like.

  Nonionic surfactants include, for example, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, etc. as optional ones other than (C) and (D). Examples of the amphoteric surfactant include lauryl dimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, coconut oil fatty acid amide propyldimethylaminoacetic acid betaine, coconut oil fatty acid amide. And propylbetaine.

  Arbitrary surfactant may be 1 type and may be a combination of 2 or more types. When the surfactant is added, the total amount of the surfactant including (C) and (D) is preferably 1.0 to 10% by mass in the composition.

  Examples of the thickener include the following: sugar alcohols such as sorbit, xylit, maltitol, and lactitol; polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol, 1,3-butylene glycol, and polypropylene glycol; Alcohols such as ethanol and denatured ethanol; sugar alcohol reduced starch saccharified products and the like.

  One type of thickener may be used, or a combination of two or more types may be used. The compounding quantity in the case of mix | blending a thickener is 5-60 mass% normally when the whole composition is 100 mass%.

  The perfume may be any known perfume used in dentifrice compositions, and for example, the following perfume ingredients can be used: peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, Clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, Natural fragrances such as bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Iris concrete, absolute peppermint, absolute rose, orange flower; Rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene , Menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octyl acetate, citral, pulegone, calbeet acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate , Ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethylsulfur Ido, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate and other single flavors; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor Formulated flavors such as tropical fruit flavors.

  The perfume component may be one type or a combination of two or more types. The blending amount when blending the fragrance component is preferably 0.000001 to 1% by mass in the composition, although it depends on the fragrance tone and each fragrance component. The total amount of the fragrance is preferably 0.01 to 2% by mass in the composition.

  Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perlartin, thaumatin and the like.

  Examples of the colorant include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201 and Blue No. 204. , Green No. 3, titanium oxide and the like.

  Examples of the preservative include parabens such as butyl paraben, methyl paraben, and ethyl paraben, sodium benzoate, and the like.

  The blending amount in the case of blending a sweetener, a coloring agent, and a preservative can be set within a range not impeding the effect of the present invention and a range of a usual blending amount for a dentifrice.

  Examples of the various drugs include various drugs that can be added to the dentifrice composition other than the component (A), such as the following: water-soluble phosphate compounds such as potassium phosphate and sodium salt of orthophosphate Enzymes such as dextranase, amylase, proteinase, mutanase; tranexamic acid, epsilon-aminocaproic acid, aluminum chlorohydroxy allantoin, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, copper Sodium chlorophyllin, chlorophyll, chelating phosphate compounds (such as glycerophosphate), copper compounds (such as copper gluconate), aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and their derivatives Glycyrrhizic acid and its salts, glycyrrhetinic acid, polyvinyl pyrrolidone, epi-dihydro cholesterol, triclosan, lysozyme chloride; polyphosphates, anticalculus agents such as zeolite. The various drugs may be one type or a combination of two or more types. In addition, each compounding amount of the drug can be an appropriate effective amount.

The manufacturing method of the dentifrice composition of this invention is not specifically limited, According to dosage form, it can manufacture with a well-known manufacturing method. For example, the said component (A)-(D), water, and another arbitrary component as needed can be mix | blended and manufactured by a normal method.
The container which accommodates the dentifrice composition of this invention is not restrict | limited in particular, Usually, the container used for a dentifrice composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon, laminated tube containers, and the like can be used.

(Examples 1-3)
With the composition shown in Table 1, a dentifrice composition was produced by a known dentifrice production method.

  Each dentifrice composition was evaluated as follows.

(1) Method for evaluating retention of fluorine ions The manufactured dentifrice composition was diluted 4-fold with purified water and centrifuged at 3000 rpm for 10 minutes. A hydroxyapatite (HA) disk (Φ7 mm, thickness 3.5 mm, manufactured by PENTAX) was immersed in the supernatant for 3 minutes and immediately washed with purified water. The NaF concentration in the dentifrice composition was adjusted assuming that a general dentifrice was diluted four times in the oral cavity. After the HA disk was dried, the upper surface of the HA disk was decalcified with acid for 2 minutes. The decalcified liquid was recovered, and the fluoride ion concentration contained in the decalcified liquid was measured with a fluorine ion meter (Orion 1115000 4-Star: manufactured by Thermo Fisher Scientific Co., Ltd.). An average value (N = 6) was calculated and used as the amount of fluoride ions in the extract. The amount of fluoride ions in the extract of each dentifrice composition was compared with the amount of fluoride ions in the extract of the control product, and classified into ◎, ○, Δ, and × according to the following evaluation criteria. The results of classification are shown in Table 1 as the retention of fluorine ions.

(Fluorine ion retention evaluation criteria)
◎: The amount of fluoride ions in the extract is significantly higher than the control product, and the average value is 1.3 times or more. ○: The amount of fluoride ions in the extract is significantly higher than the control product, and the average value 1.1 times or more and less than 1.3 times Δ: The amount of fluoride ions in the extract was not significantly different from the control product. ×: The amount of fluoride ions in the extract was compared with the control product. Significantly lower

(2) Stickiness suppression evaluation method during use Special panelists evaluated by a sensory test using 10 people. Each panelist evaluated the test dentifrice composition filled in a laminated tube having an aperture of 8 mm on a toothbrush by using a method of brushing a normal tooth about 1.5 cm.

(Evaluation criteria for stickiness suppression during use)
5 points: no stickiness 4 points: almost no stickiness 3 points: slightly sticky 2 points: sticky 1 point: I feel quite sticky

The average of the results evaluated by 10 expert panelists is shown by the following criteria.
A: The average score is 4. 5 points or more 5. 0 points or less ○: Average score is 4. 0 points or more 4. Less than 5 points Δ: Average score is 3. 0 points or more 4. Less than 0 point ×: Average score is 3. Less than 0

・ Hydroxyethylcellulose dimethyldiallylammonium chloride: “CELLCOAT L-200” manufactured by Akzo Nobel)

Example 4
(A) Sodium fluoride 0.21
(B) Hydroxyethylcellulose dimethyl diallylammonium chloride 0.05
(C) Polyoxyethylene (20) hydrogenated castor oil 1.3
(D) Polyoxyethylene (5) stearyl ether 0.3
Sodium lauryl sulfate 1
Sodium alginate 1
Carrageenan 0.5
Sorbit liquid (70%) 45
Propylene glycol 3
Silicic anhydride (abrasive) 20
Silicic anhydride (thickening silica) 4
Titanium oxide 0.4
Saccharin sodium 0.2
Fragrance 1.3
Purified water balance (total 100% by mass)

(Example 5)
(A) Sodium fluoride 0.21
(B) Hydroxyethylcellulose dimethyl diallylammonium chloride 0.05
(C) Polyoxyethylene (20) hydrogenated castor oil 1.8
(D) Polyoxyethylene (3) stearyl ether 0.5
Sodium lauryl sulfate 1
Sodium alginate 1
Carrageenan 1
Sorbit liquid (70%) 40
Propylene glycol 3
Silicic anhydride (abrasive) 20
Silicic anhydride (thickening silica) 2
Titanium oxide 0.4
Saccharin sodium 0.2
Fragrance 1.3
Purified water balance (total 100% by mass)

(Example 6)
(A) Sodium fluoride 0.21
(B) Hydroxyethylcellulose dimethyl diallylammonium chloride 0.05
(C) Polyoxyethylene (20) hydrogenated castor oil 1.3
(D) Polyoxyethylene (5) stearyl ether 0.3
Sodium lauryl sulfate 1
Palm oil fatty acid amidopropyl betaine 2
Dextranase 0.2
Sodium alginate 1
Xanthan gum 1
Sorbit liquid (70%) 40
Propylene glycol 3
Silicic anhydride (abrasive) 20
Silicic anhydride (thickening silica) 6
Titanium oxide 0.4
DL-alanine 0.2
Saccharin sodium 0.2
Fragrance 1.3
Purified water balance (total 100% by mass)

Claims (2)

(A) sodium fluoride,
(B) hydroxyethylcellulose dimethyl diallylammonium salt,
(C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 10 to 30 moles,
(D) It contains polyoxyethylene alkyl ether having 12 to 18 carbon atoms and an average ethylene oxide mole number of 3 to 8 in the alkyl group, and the ratio of component (D) / (C) is 0.1 to 0.42. Dentifrice composition characterized in that The dentifrice composition for oral cavity according to claim 1, comprising 0.9 to 2.0 mass% of component (C) and 0.1 to 0.7 mass% of component (D).