JP6522877B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition which is hypoallergenic and highly foamable.

  In oral compositions such as dentifrices and mouthrinses, a surfactant is usually incorporated for the purpose of enhancing the detergency and further giving the user a pleasant feeling of use and a feeling of cleaning by foaming in the oral cavity. There is. The surfactant used in such an oral composition is required to have high safety because it is applied to the oral mucosa. An anionic surfactant such as sodium lauryl sulfate or sodium laureth sulfate, which can satisfy the safety for the oral cavity, can exhibit high foaming property, and is relatively inexpensive, is conventionally used.

  In addition, in order to enhance the foamability of the composition for oral cavity to improve foaming in the oral cavity and to achieve a satisfactory feeling of use and a feeling of cleaning, a formulation including a large amount of the above-mentioned anionic surfactant is assembled. It is common to However, the combination of a large amount of anionic surfactant enhances the stimulation of the oral mucosa by the anionic surfactant, and in particular, patients suffering from dry mouth and hypersensitivity feel discomfort and strong irritation. Therefore, they tend to be avoided. Therefore, although an oral composition containing only a non-irritant nonionic surfactant as a surfactant is also provided (see, for example, Patent Document 1), foaming is sufficient to satisfy consumers for a high price. It was difficult to exert the nature and the cleaning action.

  In addition, amino acid based anionic surfactants such as lauroyl methyl taurine and lauroyl sarcosine are also known as mild surfactants. However, these surfactants are also inferior in foamability to conventionally used surfactants such as sodium lauryl sulfate, and foams which satisfy the user were not obtained. From such a background, there has been a demand for an oral composition having reduced irritation to the oral cavity and having sufficient foamability.

Special table 2011-514386

  An object of the present invention is to provide an oral composition which is mild and has excellent foamability.

  As a result of intensive studies to solve the above problems, the present inventors applied the compound to the mouth by combining and combining an amino acid based anionic surfactant, touki, peony and methyl salicylate in a predetermined ratio. It has been found that an oral composition having sufficient foaming power can be obtained while the irritation during the treatment is reduced. The present invention has been completed as a result of further studies based on these findings.

That is, the present invention provides the composition for oral cavity of the following aspect.
Item 1. (A) An amino acid type anionic surfactant, and (B) at least one selected from the group consisting of a touki, a peony, salicylic acid, a derivative of salicylic acid and a salt of salicylic acid, and based on 100 parts by weight of the component (A) The composition for oral cavity whose content of the said (B) component is 0.1-500 weight part.
Item 2. The composition for oral cavity described in Item 1, wherein the content of the component (B) is 2 to 200 parts by weight with respect to 100 parts by weight of the component (A).
Item 3. The composition for oral cavity as described in said claim | item 1 or 2 in which the said amino acid type | system | group anionic surfactant has a C8-C18 saturated or unsaturated acyl group.
Item 4. The composition for oral cavity as described in any one of Items 1 to 3, wherein the ratio of the amino acid based anionic surfactant to the total weight of the anionic surfactant contained in the composition for oral cavity is 50% by weight or more.
Item 5. The component (A) is lauroyl methyl taurine, a salt of lauroyl methyl taurine,
The oral composition according to any one of Items 1 to 4, which is at least one selected from the group consisting of lauroyl glutamic acid, a salt of lauroyl glutamic acid, lauroyl sarcosine, and a salt of lauroyl sarcosine.
Item 6. The oral composition according to any one of Items 1 to 5, wherein the component (A) is lauroyl methyl taurine and / or a salt thereof.
Item 7. 7. The composition for oral cavity described in any one of Items 1 to 6, which is a dentifrice or a mouthwash.

  According to the composition for oral cavity of the present invention, irritation and pain when applied to the oral cavity can be reduced, and sufficient foaming can be realized as a composition for oral cavity. Therefore, according to the present invention, it is possible to provide an oral composition having excellent feeling in use and practicality.

1. Composition for oral cavity The composition for oral cavity of the present invention is at least one selected from the group consisting of (A) an amino acid based anionic surfactant, (B) touki, peony, salicylic acid, derivatives of salicylic acid and salts of salicylic acid. And a seed, and the content of the component (B) is 0.1 to 500 parts by weight with respect to 100 parts by weight of the component (A). Hereinafter, the composition for oral cavity of this invention is explained in full detail.

(A) Component The amino acid-based anionic surfactant which is the component (A) of the composition for oral cavity of the present invention can be appropriately selected from known ones and used, for example, having 8 to 18 carbon atoms, preferably Examples are amino acids or taurines having a saturated or unsaturated acyl group having a carbon number of 10 to 16, more preferably 10 to 14, and further preferably 12 to 14. The acyl group is formed by combining an amino group of an amino acid or taurine with a carboxyl group. Here, specific examples of the acyl group include octyl group, decyl group, lauroyl group, myristoyl group, palmitoyl group, stearyl group and the like.

  In addition, the amino acid surfactant of the present invention may be used in the form of a salt, for example, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as magnesium; monoethanolamine, triethanolamine and the like And organic amine salts of

  Specific examples of the component (A) of the present invention include acyl sarcosine and its salts such as lauroyl sarcosine, sodium lauroyl sarcosine and myristoyl sarcosine triethanolamine; lauroyl methyl-β-alanine, lauroyl methyl-β-alanine sodium, palmitoyl methyl Acylalanine such as β-alanine sodium and salts thereof; lauroyl methyltaurine, lauroylmethyltaurine sodium, sodium cocoylmethyltaurine, palmitoylmethyltaurine, palmitoylmethyltaurine sodium and other acyltaurines and salts thereof; myristoyl sodium glutamate, cocoyl glutamate potassium , Lauroyl glutamate, sodium lauroyl glutamate, lauroyl glutamate triethanolate Acyl glutamic acid and its salts such emissions; myristoyl glutamate, cocoyl glutamate, acyl glutamic like such as lauroyl glutamate are exemplified. Among these, lauroyl methyl taurine or a salt thereof, lauroyl glutamic acid or a salt thereof, lauroyl sarcosine or a salt thereof, or the like from the viewpoint of safety when applied to the mouth and lower irritation to the oral mucosa. Preferably, lauroyl methyl taurine or a salt thereof is mentioned as a further preferred one. One of these may be used alone, or two or more may be used in combination.

  About lauroyl methyl taurine sodium, it is commercially available from Nikko Chemicals Co., Ltd. etc., for example. Lauroyl glutamate sodium is commercially available, for example, from Ajinomoto Co., Ltd. Lauroyl sarcosine sodium is commercially available, for example, from Nikko Chemicals Co., Ltd., Kawaken Fine Chemical Co., Ltd., Croda Japan Co., Ltd., and the like.

  The content of the component (A) in the composition for oral cavity of the present invention is 0.3 to 2.5% by weight, preferably 0.5 to 2% by weight, more preferably 0. 5 to 1.5% by weight, more preferably 0.5 to 1.0% by weight can be mentioned.

  The composition for oral cavity of the present invention is not limited to the surfactant generally used in the field other than the above-mentioned amino acid based anionic surfactant. However, the composition for oral cavity of the present invention achieves a satisfactory foamability to the user while reducing irritation when applied to the mouth by using an amino acid based anionic surfactant. . Therefore, the amino acid-based anionic surfactant contained in the composition for oral cavity of the present invention is 50% by weight or more, preferably 80% by weight or more, more preferably 90% by weight with respect to the total weight with other surfactants. It is desirable to be included in a proportion of% or more. Further, among the surfactants contained in the composition for oral cavity of the present invention, the ratio of the amino acid based anionic surfactant to the total weight of the anionic surfactant is 50% by weight or more, preferably 80% by weight or more, It is desirable that 90% by weight or more is contained.

(B) Component In the composition for oral cavity of the present invention, as the component (B), at least one selected from the group consisting of toki, shakuyaku, salicylic acid, derivatives of salicylic acid and salts of salicylic acid is used.

  Touki (Toki) is the root of the Tochii Angelica acutiloba Kitagawa or other related plants of the Umbelliferae (Umbelliferae), and is usually blanched, and as a herbal medicine (Japanese Pharmacopoeia), a gynecological drug, a medicine for cold, health It is used by combining it with prescriptions such as tonics, drugs for neuropsychiatric drugs and drugs for urinary tract diseases. Touki is commercially available from Maruzen Pharmaceutical Co., Ltd., Mikuni Co., Ltd., Ichimaru Falcos Co., Ltd., and the like.

  A peony (peculiar) is the root of Paeonia lactiflora Pallas or other related plants of the family Peaoniaceae, and mainly as an herbal medicine (Japanese Pharmacopoeia) an analgesic and antispasmodic drug (a gastrointestinal drug), a gynecological drug, a medicine for chills, Used for cold medicine and other uses. Peony is a herbal medicine name (Japanese Pharmacopoeia) and a plant name. The peony is commercially available from Maruzen Pharmaceutical Co., Ltd., Mikuni Co., Ltd., Ichimaru Falcos Co., Ltd., and the like.

Salicylic acid is a compound represented by C ₆ H ₄ (OH) COOH. In the present invention, in addition to salicylic acid as the component (B), derivatives of salicylic acid and salts of salicylic acid can be used as well. As derivatives of salicylic acid, for example, acetylsalicylic acid, sulfosalicylic acid, methyl salicylate, ethyl salicylate, glycol salicylate, ethylene glycol salicylate, ethylene glycol salicylate, dipropylene glycol salicylate, titanium salicylate, 2-ethylhexyl salicylate, homomentyl salicylate, phenyl salicylate, salicylic acid amide, etc. It can be mentioned. Moreover, as a salt of salicylic acid, for example, alkali metal salts such as sodium and potassium; alkaline earth metal salts such as magnesium and the like can be mentioned. Specific examples of the salt of salicylic acid used in the present invention include sodium salicylate, potassium salicylate, calcium salicylate, magnesium disalicylate and the like. Among these, salicylic acid, salts of salicylic acid, methyl salicylate and ethyl salicylate are mentioned as suitable ones, and among these, methyl salicylate is mentioned as further preferable one. Methyl salicylate is commercially available, for example, from Tokyo Chemical Industry Co., Ltd., Filmenich Co., Ltd., JQC Co., etc.

  In the present invention, as the component (B), one or two or more species of touki, peony, salicylic acid, a derivative of salicylic acid or salicylate may be used alone or in combination. Specific combinations in the case of using two or more kinds in combination are not particularly limited, and examples thereof include touki and peony; touki and methyl salicylate; peony and methyl salicylate; touki, peony and methyl salicylate and the like. In particular, from the viewpoint of a high effect of enhancing foaming, a combination of touki and methyl salicylate or a combination of touki, peony and methyl salicylate is preferred. Moreover, the ratio in the case of using 2 or more types together is not specifically limited, Although it may adjust suitably, for example, each compound can be used by equivalent amount.

The composition for oral cavity of the present invention contains the component (B) in a ratio of 0.1 to 500 parts by weight with respect to 100 parts by weight of the component (A). Moreover, as a preferable mixture ratio of (B) component, 1 to 200 parts by weight, more preferably 2 to 200 parts by weight, and still more preferably 10 to 200 parts by weight can be mentioned. For example, in the case of using Touki as the component (B), the preferable blending ratio is 1 to 200 parts by weight, more preferably 2 to 200 parts by weight, still more preferably 10 to 200 parts by weight with respect to 100 parts by weight of the component (A). Department is listed. In addition, a preferable blending ratio in the case of using peony as the component (B) is 1 to 200 parts by weight, more preferably 2 to 200 parts by weight, still more preferably 6.6 to 100 parts by weight of the component (A). 200 parts by weight can be mentioned. Furthermore, when using at least one selected from the group consisting of salicylic acid, derivatives of salicylic acid and salts of salicylic acid, a preferable blending ratio is 1 to 200 parts by weight, more preferably 2 with respect to 100 parts by weight of the component (A). -200 parts by weight, more preferably 10-200 parts by weight can be mentioned.

  By blending the component (B) at such a ratio, the foaming power of the component (A) can be improved, and rich foaming in the mouth can be realized, and the use feeling and cleaning feeling superior to the user can be realized. Can be given. Moreover, what is necessary is just to adjust so that the said compounding ratio may be satisfy | filled as a total amount of (B) component, when using 2 or more types together as (B) component.

2. Preferred embodiment The dosage form of the composition for oral cavity of the present invention may be any of powder, liquid, gel, granules, and tablets, and it is possible to clean the mouth, give a refreshing feeling, sterilize, prevent bad breath, etc. As long as it is applied to the intraoral as an object, it can be appropriately selected from conventionally known modes. Specific examples of the dosage form of the composition for oral cavity of the present invention include toothpastes such as powder toothpaste, toothpaste, gel toothpaste and liquid toothpaste, and mouthwash. In addition, the liquid dosage form may be a type that is used as it is as a stock solution, or may be a concentration type that is used by diluting at the time of use. By applying a dosage form of the composition for oral cavity of the present invention to a dentifrice or a mouthwash, it is possible to realize the reduction of irritation to the oral mucosa and the excellent foamability more remarkably when applied to the mouth From these, these are mentioned as suitable dosage forms in the present invention. In particular, in the toothpaste and gel dentifrice, the correlation between the foamability and the feeling of cleaning is strong, and when the foamability is improved, the difference can be perceived sensitively, so toothpaste and gel toothpaste The agent is mentioned as a suitable dosage form in the present invention.

  In the composition for the oral cavity of the present invention containing the above components (A) and (B), various kinds of abrasives, foaming agents, and the like which can be usually blended in the composition for oral cavity within the range not impairing the effects of the present invention. Add additives such as thickener, flavor, sweetening agent, wetting agent, antioxidant, pH adjuster, coloring agent, preservative, etc., pharmacologically active ingredient, solvent etc. It can be prepared.

  As the polishing agent, various polishing agents generally used in oral compositions can be blended, and are not particularly limited. For example, primary calcium phosphate, secondary calcium phosphate dihydrate and anhydrate Calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silica gel, anhydrous silica, aluminum silicate, precipitated silica, insoluble sodium metaphosphate, magnesium phosphate, magnesium carbonate, calcium sulfate, polymethacrylic acid And methyl acid, bentonite, zirconium silicate, titanium-bonded silicate and the like.

  As the foaming agent, an anionic surfactant other than the amino acid based anionic surfactant, which is the component (A) of the present invention, a nonionic surfactant, a cationic surfactant, or an amphoteric surfactant can be blended. More specifically, examples of the anionic surfactant include sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium α-olefin sulfonate and the like. As a nonionic surfactant, for example, sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan monostearate, polyoxyethylene higher alcohol ether, polyoxyethylene cured Castor oil, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerin fatty acid ester and the like can be mentioned. Examples of the cationic surfactant include lauryl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzethonium chloride, cetyl pyridinium chloride, benzalkonium chloride, stearyl dimethyl benzyl ammonium chloride and the like. As an amphoteric surfactant, for example, coconut oil fatty acid amidopropyl betaine, lauryl dimethylaminoacetic acid betaine, lauryl dimethyl amine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine, N-lauryl diaminoethyl glycine , N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like. In the present invention, the blending ratio of surfactants other than the amino acid based anionic surfactant is desirably 2.5% by weight or less, preferably 2% by weight or less, based on the whole composition.

  As the thickener, xanthan gum, sodium alginate, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, polyvinyl pyrrolidone and the like can be mentioned.

  As a flavor, l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene Spiranthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furanoleol, maltol, ethyl maltol, gamma / delta decalactone, gamma / Deltown Decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthylca Flavor components such as Bonate; Peppermint oil, spearmint oil, eucalyptus oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil etc. Natural essential oils; Blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt etc. may be mentioned.

  As the sweetening agent, saccharin sodium, acesulfame K, stevioside, neohespolysil dihydrochalcone, glycyrrhizin, perilaltin, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinnamic aldehyde, aspartame, xylitol, erythritol and the like can be mentioned.

  The wetting agent may, for example, be Sorbit, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol or the like.

  As an antioxidant, rosemary extract, stevia extract, sunflower seed extract, propyl gallate, dibutylhydroxytoluene, butylhydroxyanisole, L-cysteine hydrochloride, phytic acid, hydroquinone and its glycoside, nor dihydrochloride Guararetic acid, guaiac fat, polyphenol, tocopherol acetate, pine extract, ascorbic acid and the like can be mentioned.

  Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and their potassium salts, sodium salts or ammonium salts, sodium hydroxide and the like. The pH of the composition for oral cavity of the present invention is not particularly limited as long as there is no problem with safety in the oral cavity and the human body. For example, 30 g of the composition for oral cavity was dissolved in 70 mL of water at 25 ° C. The pH range of the case includes pH 4-9. The pH of the composition for oral cavity of the present invention can be adjusted to the relevant range using the above-mentioned pH adjuster, if necessary.

  As a coloring agent, for example, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Yellow No. 1, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204 Green, No. 3, mica titanium, titanium oxide and the like.

  Examples of the preservative include parabens such as sodium benzoate, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, cetyl pyridinium chloride, alkyldiaminoethyl glycine hydrochloride, potassium sorbate and the like.

  As pharmacologically active ingredients, for example, bactericidal or antibacterial agents such as chlorhexidine, triclosan, isopropylmethylphenol, cetyl pyridinium chloride, zinc gluconate, zinc citrate and the like; anti-inflammatory agents such as tranexamic acid, glycyrrhizinic acid dipotassium salt; allantoin, allantoin chlorate Hydroxyaluminum, ascorbic acid, lysozyme chloride, glycyrrhizinic acid and salts thereof, astringent agents such as sodium chloride and aluminum lactate; enzymes such as dextranase, amylase, protease, mutanase, lysozyme; hypersensitivity inhibitors such as strontium chloride and potassium nitrate And the like, and these can be used in a pharmaceutically acceptable range.

  As the solvent, ethanol, isopropyl alcohol or the like can be used.

  The content of optional components in the composition for oral cavity of the present invention may be appropriately set according to the amount of each component to be blended, the type of carrier, additive, etc., but 1 to 80% by weight as a total Be

  The oral composition of the present invention may also contain pharmacologically acceptable conventionally known carriers. Examples of such carriers include aqueous carriers such as water (ion-exchanged water, distilled water, purified water etc.), physiological saline, etc .; and oily carriers such as higher fatty acids, vegetable oils, animal oils, silicone oils, metal soaps, etc. . In the present invention, the content of these carriers is adjusted to correspond to the components (A) and (B) and the balance other than the other optional components in the composition for oral cavity.

  The application amount of the composition for oral cavity of the present invention is not particularly limited and may be appropriately adjusted depending on the application, but in the case of a toothpaste, for example, 0.2 to 1 g may be mentioned. In the case of mouth drops, 5 to 20 mL can be mentioned.

  The present invention will be specifically described by way of examples and the like below. However, the present invention is not limited to these.

[Evaluation of foaming power]
The dentifrices shown in Tables 1 to 10 below were prepared by degassing the raw materials at room temperature (about 25 ° C.). More specifically, component (A), purified water, concentrated glycerine, sorbit solution and silicic anhydride are stirred and mixed for 10 minutes and then separately mixed with component (B), ethanol and polyoxyethylene hydrogenated castor oil. Was added and stirred for 10 minutes, and finally sodium carboxymethylcellulose and sodium polyacrylate were added and stirred for another 15 minutes for degassing.

  To 15 g of the obtained dentifrice, 75 g of purified water (25 ° C.) was added, and well suspended to prepare a sample solution. 60 mL of the sample solution was placed in a measuring cylinder, and the stirring blade of the homogenizer (System POLYTRON PT-K) was placed at a position about two thirds from the liquid surface. After rotating for 10 seconds at a rotation speed of about 5000 rpm at room temperature (about 25 ° C.), when the stirring blade is stopped and the foam is stabilized (after about 5 seconds), the graduation (mL Was measured. The difference between the foam portion and the liquid portion (60 mL) was taken as the foam amount as shown in the following Formula 1.

Formula 1
Foaming amount = scale on top of foam part-liquid part (60 mL)

  The results are shown in Tables 1 to 10 below.

  As shown in Table 1, when sodium lauroyl methyl taurine is used as the amino acid-based anionic surfactant, the surfactant and the herbal medicine or essential oil other than the component (B) of the present invention, such as birch, oat, coriander or eucalyptus The amount of foaming of the dentifrices of Reference Comparative Examples 1 to 4 combined with the above is lower than that of dentifrices containing sodium lauroyl methyl taurine alone (Comparative Example 1), and a satisfactory amount of foaming can not be obtained. Indicated.

  As shown in Tables 2 to 4, using sodium lauroyl methyl taurine as the component (A) and combining methyl salicylate, toki or peony as the component (B), it was shown that excellent foamability can be obtained. (Implementation 1-23).

  When 0.5% by weight of sodium lauroyl methyl taurine is contained as component (A), the blending amount of methyl salicylate as component (B) is 10 to 200 parts by weight with respect to 100 parts by weight of component (A). As a result, it was shown that the amount of increase in foaming can be made to be 115% or more as compared with the case where the component (A) alone is contained (Comparative Example 1), and a further excellent foaming power can be provided (Example 1-4). Further, even when using Touki as the component (B), the foaming increase amount can be made 115% or more by setting the blending amount of the touki to 10 to 200 parts by weight with respect to 100 parts by weight of the component (A). (Examples 8 to 11). Furthermore, in the case of using peony as the component (B), the foaming increase amount can be made 115% or more by setting the blending amount of peony to 6.6 to 200 parts by weight with respect to 100 parts by weight of the component (A). It was shown that when the blending amount of peony is 6.6 to 50 parts by weight (Examples 14 to 18), the foamability can be further improved (Examples 15 to 18).

  Moreover, when the salicylic acid methyl salicylate, touki, and peony were respectively used in combination as the component (B), an increase in the amount of foaming was similarly shown (Examples 20 to 23). In particular, it was shown that higher foaming power can be imparted when methyl salicylate and toki were combined (Example 20) and when methyl salicylate, touki and peony were combined (Example 21).

  From Tables 5 and 6, when 1% by weight of sodium lauroyl methyl taurine is contained as the component (A), the blending amount of methyl salicylate of the component (B) is 10 to 200 parts by weight with respect to 100 parts by weight of the component (A) As a result, it was shown that the amount of increase in foaming was 114% or more, and it was possible to impart more excellent foamability (Examples 24 to 27). Moreover, when using a touki as (B) component, it was shown that the still more outstanding foaming power is provided by the compounding quantity with respect to 100 weight part of (A) component being 10-200 weight part. Examples 29-32). Furthermore, even when using peony as the component (B), an increase in the amount of foaming was observed by setting the amount to 10 to 200 parts by weight with respect to 100 parts by weight of the component (A) (Examples 34 to 37)

  As shown in Tables 7 and 8, when 2 wt% of lauroyl methyl taurine sodium is contained as the component (A), the blending amount of methyl salicylate of the component (B) is 10 to 10 parts by weight of the component (A). By setting the amount to 50 parts by weight, it was possible to impart even more excellent foaming power (Examples 40 to 42). Moreover, when using Touki as a (B) component, the still higher foamability was shown by making the compounding quantity with respect to 100 weight part of (A) component into 10 to 50 weight part (Examples 45 to 47) ). Furthermore, in the case of using peony as the component (B), higher foamability was shown by setting the compounding amount to 10 to 200 parts by weight with respect to 100 parts by weight of the component (A). (Examples 49-52). In Examples 44, 48, and 53, the increase rate of the foam amount is about 107% in all cases, and the foam increase amount is relatively small as compared with the other examples. When applied to a brush and brushed using a toothbrush, it is possible to realize a moderate improvement in lathering, and a practically sufficient foaming power is imparted.

  As shown in Table 9, even when sodium lauroyl glutamate is used as component (A), the amount of foaming is obtained by combining it with component (B) as in the case where sodium lauroyl methyl taurine is used as component (A). It was shown that can increase and give excellent foaming power.

  As shown in Table 10, even when sodium lauroyl sarcosine is used as component (A), the amount of foaming is obtained by combining it with component (B) as in the case where sodium lauroyl methyl taurine is used as component (A). It was shown that can increase and give excellent foaming power.

  In addition, when the dentifrices of Examples 1 to 65 in Tables 1 to 10 were actually applied in the mouth and brushed using a toothbrush, not only the improvement of foaming but also the improvement of cleaning effect in correlation with the improvement of foaming. I was able to feel

[Formulation example: toothpaste]
Tables 11 to 17 below show formulation examples of toothpaste. The toothpaste is prepared by stirring and mixing the component (A), purified water, concentrated glycerin, sorbit solution, silicic anhydride, silicic anhydride, dipotassium glycyrrhizinate, allantoin, pine extract, sodium citrate and citric acid for 10 minutes and separately mixing Stirred (B) component, ethanol, polyoxyethylene hydrogenated castor oil, tocopherol acetate and l-menthol for 10 minutes, finally add sodium carboxymethylcellulose and sodium polyacrylate, and stir for additional 15 minutes for degassing It was done by

[Example of formulation: liquid dentifrice, mouthwash]
Table 18 below shows formulation examples of liquid dentifrices or mouthrinses. Liquid dentifrice or mouthrint was mixed separately after stirring (A) component, purified water, concentrated glycerin, sorbit solution, dipotassium glycyrrhizinate, allantoin, pine extract, sodium citrate and citric acid for 10 minutes It is prepared by further stirring for 10 minutes with the component (B), ethanol, tocopherol acetate, polyoxyethylene hydrogenated castor oil and L-menthol.

  The oral composition of any of the above formulations has a foaming power that reduces the irritation to the mouth and provides a satisfactory feeling of use and a feeling of cleaning.

Claims (8)

(A) an amino acid type anionic surfactant, and (B) at least one selected from the group consisting of a touki, peony, salicylic acid, methyl salicylate, ethyl salicylate, and a salt of salicylic acid,
(A) the component is an amino acid based anionic surfactant and (B) the component contains peony, or
The component (A) comprises at least one selected from the group consisting of lauroyl glutamic acid and / or a salt of lauroyl glutamic acid and the component (B) comprises a salt of salicylic acid, methyl salicylate, methyl salicylate, ethyl salicylate and salicylic acid;
The composition for oral cavity whose content of the said (B) component is 0.1-500 weight part with respect to 100 weight part of said (A) component. (A) an amino acid type anionic surfactant, and (B) at least one selected from the group consisting of a touki, peony, salicylic acid, methyl salicylate, ethyl salicylate, and a salt of salicylic acid,
The component (A) contains lauroyl methyl taurine and / or a salt thereof, and the component (B) contains chili pepper,
The content of the component (B) is 0.1 to 500 parts by weight with respect to 100 parts by weight of the component (A),
The composition for oral cavity whose ratio of the said (A) component with respect to the total weight of the anionic surfactant contained in the composition for oral cavity is 50 weight% or more.   The composition for oral cavity described in Claim 1 or 2 whose content of the said (B) component is 2-200 weight part with respect to 100 weight part of said (A) component.   The composition for oral cavity as described in any one of Claims 1-3 in which the said amino acid type anionic surfactant has a C8-C18 saturated or unsaturated acyl group.   The oral composition according to any one of claims 1, 3 and 4, wherein the ratio of said amino acid based anionic surfactant to the total weight of the anionic surfactant contained in the composition for oral cavity is 50% by weight or more. object.   When the component (A) is an amino acid anionic surfactant and the component (B) is peony, the component (A) is lauroyl methyl taurine, a salt of lauroyl methyl taurine, lauroyl glutamate, a salt of lauroyl glutamate, lauroyl sarcosine The oral composition according to claim 1, which is at least one selected from the group consisting of a salt of lauroyl sarcosine and a salt of lauroyl sarcosine.   The oral composition according to claim 6, wherein the component (A) is lauroyl methyl taurine and / or a salt thereof. The oral composition according to any one of claims 1 to 7, which is a dentifrice or a mouthwash.