KR20120086685A - Dentifrice composition - Google Patents

Abstract

The present invention provides a dentifrice composition that is excellent in biofilm sterilization and hypersensitivity suppressing action, and has no unpleasant taste and excellent usability. At least one selected from (A) isopropylmethylphenol, (B) potassium nitrate, aluminum lactate, and strontium chloride, and (C) at least one selected from 3-octanol, 3-octyl acetate, 3-octanone, and fencone. Or two or more flavor components, (D) anionic surfactant and / or nonionic surfactant. Furthermore, (E) anisealdehyde is mix | blended with the said horseshoe composition.

Description

Dentifrice composition {DENTIFRICE COMPOSITION}

The present invention relates to a dentifrice composition which is excellent in biofilm sterilizing power and perceptual hypersensitivity, and has no unpleasant taste and excellent usability.

Dentin perceptual hypersensitivity is a disease in which dentin is exposed by the retraction of the gums due to the progression of periodontal disease, and pain is caused by impulses such as abrasions and cold substances transmitted to the nerve through the dentinal tubules. Therefore, in order to prevent or suppress dentin perceptual hypersensitivity, it has both effects such as sterilization of oral biofilm which is the cause of periodontal disease, and relieving pain due to nerve dung and dentin capillary blockade using the components of perceptual hypersensitivity. The composition for oral cavity to be very effective.

Sterilization of the oral biofilm is directed to various bacteria in the oral biofilm, which is considered to be the cause of the two major oral diseases of caries and periodontal disease. Examples of oral bacteria related to oral diseases include streptococcus such as Streptococcus mutans related to caries, and anaerobic grams such as P. gingivalis such as porphyromonas-Jingivalis related to periodontal disease. Oral bacteria such as Fusobacterium nucleatum related to the cause of bad breath, as well as bacteria that have negative bacilli. As an effective means for the prevention and improvement of oral diseases, it is said that it is useful to keep the pathogenic bacteria count in the oral biofilm at a low level.

To reduce the number of pathogenic bacteria in the oral cavity, it is effective to use a hardly water-soluble fungicide, a cationic stone fungicide, and an anionic fungicide. Especially for the bacteria in the biofilm, isopropylmethylphenol having a high penetration sterilization effect is an oral biofilm. Has been proposed (Patent Document 1: Japanese Patent Application Laid-Open No. 2006-182662, Patent Document 2: Japanese Patent Application Laid-Open No. 2006-124315, Patent Document 3: Japanese Patent Laid-Open No. 2005-179266, Patent Document 4). : Japanese Patent Laid-Open No. 2006-69909).

On the other hand, as a preventive measure for dentin perceptual hypersensitivity, it has a neural glutamic action and a dentin capillary blockage effect, and known potassium nitrate, aluminum lactate, strontium chloride, and the like as an active ingredient for the prevention of perceptual hypersensitivity are formulated into the oral composition, and the pain is prevented. Mitigating techniques have been proposed. For example, Patent Document 5 (U.S. Pat.No. 3,386,063) discloses that a dentifrice containing potassium salts such as potassium nitrate reduces its hypersensitivity after brushing for several weeks. 48926) proposes a treatment method in which potassium nitrate is imparted to the gums and the periodontal tissue. Further, Patent Document 7 (Japanese Patent Laid-Open No. 5-155745) discloses that a composition for oral cavity containing aluminum salts such as aluminum lactate suppresses dentin hypersensitivity, and Patent Document 8 (Japanese Patent Laid-Open No. 2001-172146) The oral composition which contains aluminum salts, such as potassium nitrate and aluminum lactate of a specific density | concentration, is excellent in the prevention and treatment effect of dentin hypersensitivity hypersensitivity, and has good usability is proposed. Patent document 9 (the specification of US Patent 33122483) is proposed about the composition for oral cavity containing strontium chloride.

It is considered that by mixing a poorly water-soluble bactericidal component such as isopropylmethylphenol and a perceptual hypersensitivity component in the dentifrice composition, the bactericidal effect of the periodontal biofilm and the dentin hypersensitivity relieving effect can be combined. However, the combination of isopropylmethylphenol with potassium nitrate, aluminum lactate, strontium chloride, and the perceptual hypersensitivity component produces a distinctive unpleasant taste, and the composition containing both components has the drawback that the feeling of use is significantly impaired due to such unpleasant taste. Improvement of this point is desired.

About the problem of the unpleasant taste derived from isopropylmethylphenol, the technique which reduces the strange taste of an antibacterial component, for example by combining specific acyl sarcosine salt in combination with a specific compounding ratio with respect to phenoxy ethanol (patent document 10: Japan) Japanese Patent Application Laid-Open No. 2007-161613) discloses a technique (patent document 11: Japanese Patent Application Laid-Open No. 2008-143825) for reducing strange smell and strange taste by combining l-menthol and sodium chloride in a specific mass ratio with respect to isopropylmethylphenol. Known. However, when a large amount of acyl sarcosine salt is blended, oral mucosal irritation, which is thought to be derived from acyl sarcosine salt, may occur, or when the sodium chloride is blended, the type of flavor may be limited by the salty taste. New challenges are emerging.

In addition, for the problem of unpleasant taste derived from potassium nitrate, water soluble polyphosphate is blended in a specific ratio with respect to potassium nitrate, and a polyhydric alcohol is blended to improve bitterness, astringent taste convergence and neck discomfort (Patent Document 12: Japan). Japanese Patent Application Laid-Open No. 2006-96696) and a technique for masking bitter taste by combining specific organic compounds, plant extracts and acidic sodium bicarbonate (Patent Document 13: Japanese Patent Laid-Open No. 2002-302450) have been proposed. However, when mix | blending water-soluble polyphosphoric acid, the unpleasant taste derived from water-soluble polyphosphoric acid may arise, and when mix | blending a plant extract or acidic sodium bicarbonate, the unpleasant taste derived from both arises, etc., and a new problem arises. .

Regarding the problem of unpleasant taste originating in aluminum lactic acid, a technique for reducing bitterness and arin taste by adding sodium bicarbonate to a non-aqueous formulation has been proposed (Patent Document 14: Japanese Patent Laid-Open No. 2002-302429). However, in such a non-aqueous preparation, the effect of suppressing the perceptual hypersensitivity of potassium nitrate is not sufficiently obtained.

There is also a method of masking and reducing an unpleasant taste by a sweetener such as saccharin, but in this case, it cannot be said that the unpleasant taste can always be suppressed by too much emphasis on the taste of the sweetener.

In addition, Patent Document 8 is a technique for improving the astringent taste derived from potassium nitrate and aluminum lactate, and this technique cannot satisfactorily reduce the unpleasant taste peculiar to isopropylmethylphenol and the hypersensitivity suppressing component.

Moreover, when a fragrance | flavor is mix | blended in order to mask the unpleasant taste derived from isopropylmethylphenol and a perceptual hypersensitivity suppression component, you may feel an unpleasant taste in use for the unpleasant taste which the fragrance itself has.

As a technique which mix | blended isopropylmethylphenol and a fragrance component, patent document 11 is proposed, for example. As a technique which improves the bitter taste of potassium nitrate as a fragrance component, the technique (patent document 15: Unexamined-Japanese-Patent No. 2003-73282) which mix | blended anetol, a cinerol, vanillin, citronellal, and cinnamic aldehyde is proposed. In addition, the composition which mix | blended isopropyl methyl phenol and anisealdehyde is the Example 1-13 of patent document 1, the Examples 1-3 of 6, 6-12, 15-20, and patent document 16 (international publication). (Examples No. 2007/69447 pamphlet), and Examples 11 to 17, 20, 21, 23 of Patent Document 17 (Japanese Patent Laid-Open No. 2005-179266).

However, neither technique was able to sufficiently improve the unique unpleasant taste at the time of use derived from isopropylmethylphenol and the perceptual hypersensitivity component.

Therefore, there is a need for a new technique that is excellent in biofilm sterilization power and perceptual hypersensitivity action, and that an unpleasant taste derived from a blending component can be effectively reduced, and a dentifrice composition excellent in usability can be obtained.

Patent Document 1: Japanese Patent Application Laid-Open No. 2006-182662 Patent Document 2: Japanese Patent Application Laid-Open No. 2006-124315 Patent Document 3: Japanese Patent Application Laid-Open No. 2005-179266 Patent Document 4: Japanese Patent Application Laid-Open No. 2006-69909 Patent Document 5: US Patent No. 3863006 Patent Document 6: Japanese Patent Application Laid-Open No. 60-48926 Patent Document 7: Japanese Patent Application Laid-Open No. 5-155745 Patent Document 8: Japanese Patent Application Laid-Open No. 2001-172146 Patent Document 9: US Patent No. 332483 Patent Document 10: Japanese Patent Application Laid-Open No. 2007-161613 Patent Document 11: Japanese Patent Application Laid-Open No. 2008-143825 Patent Document 12: Japanese Patent Application Laid-Open No. 2006-96696 Patent Document 13: Japanese Patent Application Laid-Open No. 2002-302450 Patent Document 14: Japanese Patent Application Laid-Open No. 2002-302429 Patent Document 15: Japanese Patent Application Laid-Open No. 2003-73282 Patent Document 16: International Publication No. 2007/69447 Pamphlet Patent Document 17: Japanese Patent Application Laid-Open No. 2005-179266

This invention is made | formed in view of the said situation, and an object of this invention is to provide the dentifrice composition which is excellent in biofilm sterilization power and perceptual hypersensitivity action, and has no unpleasant taste and excellent in usability.

MEANS TO SOLVE THE PROBLEM As a result of earnestly examining in order to achieve the said objective, 1 or 2 or more types chosen from (A) isopropylmethylphenol, (B) potassium nitrate, aluminum lactate, strontium chloride, (C) 3- Surprisingly, by blending one or two or more flavor components selected from octanol, 3-octyl acetate, 3-octanone and fencon, (D) anionic surfactant and / or nonionic surfactant, The present invention has been realized by finding that a dentifrice composition which is excellent in bactericidal power and perceptual hypersensitivity, and which has no unpleasant taste and excellent in usability can be obtained.

That is, in the present invention, by using an isopropyl methylphenol and a specific perceptual hypersensitivity component in combination with a dentifrice composition containing an anionic surfactant and / or a nonionic surfactant, an excellent biofilm bactericidal and perceptual hypersensitivity action is achieved. By using together and blending a specific fragrance component in addition to these components, it is possible to effectively mask the unpleasant taste produced by the combination of isopropylmethylphenol and perceptual hypersensitivity component together with the said effect, and the unpleasant taste It also combines excellent ease of use.

In addition, although the fragrance component of the said (C) component has the characteristic fragrance all, and it is used a trace amount in combination fragrances, such as cheese, since it is an unpleasant fragrance itself, use as a fragrance | flavor of a dentifrice composition is limited. It was. When the present inventors use such a specific flavor of (C) component together with isopropylmethylphenol and a specific perceptual hypersensitivity component, surprisingly, the unique unpleasant taste derived from isopropylmethylphenol and a specific perceptual hypersensitivity component, namely I can effectively suppress the unpleasant taste peculiar to the bitterness derived from isopropylmethylphenol and the astringency derived from the perceptual hypersensitivity suppression component, and the unpleasant taste derived from a compounding fragrance is not felt anymore, and is common to a dentifrice composition until now It was confirmed that a good feeling of use, which is difficult to achieve with the fragrance used, was obtained.

In this invention, when the mass ratio of (B) component / (A) component is 2-700, biofilm sterilization power and the inhibitory effect of an unpleasant taste can be heightened more.

Moreover, in this invention, by mix | blending (E) anisealdehyde with the dentifrice composition which mix | blended said (A)-(D) component, an unpleasant taste can be reduced more and a usability can be improved further.

Therefore, this invention provides the following dentifrice composition.

Claim 1: (A) isopropylmethylphenol,

(B) one or two or more selected from potassium nitrate, aluminum lactate, strontium chloride,

(C) one or two or more flavor ingredients selected from 3-octanol, 3-octyl acetate, 3-octanone, fencone,

(D) anionic surfactants and / or nonionic surfactants

A dentifrice composition, comprising the composition.

The mass ratio of (B) component / (A) component is 2-700, The dentifrice composition of Claim 1 characterized by the above-mentioned.

3. The component (D) is an alkyl sulfate, polyoxyethylene cured castor oil and / or polyoxyethylene alkyl ether, wherein the dentifrice composition according to claim 1 or 2 is used.

Claim 4: 0.01-0.2 mass% of (A) component, 0.1-15 mass% of (B) component, 0.0001-0.1 mass% of (C) component, and 0.1-5 mass% of (D) component The dentifrice composition of Claim 1, 2 or 3 characterized by the above-mentioned.

5: The dentifrice composition according to any one of claims 1 to 4, further comprising (E) anisealdehyde.

6: The dentifrice composition according to claim 5, which contains 0.0001 to 0.1 mass% of (E) component.

7: Claims 1 to 10, prepared by mixing 10 to 70% by mass of the viscous agent, 0.1 to 5% by mass of the binder, and 0 to 50% by mass of the abrasive, and as a softener. The dentifrice composition of any one of Claims 6.

The dentifrice composition of the present invention is excellent in biofilm bactericidal power and perceptual hypersensitivity action, has no unpleasant taste, and is excellent in use, and is effective in preventing or treating dentin hypersensitivity.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is one or two or more selected from (A) isopropylmethylphenol, (B) potassium nitrate, aluminum lactate, strontium chloride, (C) 3-octanol, 3-octyl acetate, It is characterized by containing one or two or more flavor components selected from 3-octanone, fencone, (D) anionic surfactant and / or nonionic surfactant.

(A) isopropylmethylphenol used by this invention is 4-isopropyl-3-methylphenol, and can use commercial items, such as the thing sold by Osaka Chemical Co., Ltd ..

As for the compounding quantity of (A) isopropyl methyl phenol, 0.01-0.2% (mass% or less), especially 0.02-0.1% of the whole composition are suitable. If it is less than 0.01%, sufficient sterilization effect may not be exhibited, and if it exceeds 0.2%, the unpleasant taste derived from isopropylmethylphenol may become strong, and the taste may worsen.

Potassium nitrate, aluminum lactate, and strontium chloride as components (B) are blended as active ingredients for preventing or treating dentin hypersensitivity. Among them, potassium nitrate and aluminum lactate are preferably used in view of the hypersensitivity inhibitory action. Can be. A commercial item can be used for these (B) components, For example, potassium nitrate is marketed by Matsumoto Bridge, aluminum lactate is marketed by Musashino Chemical Co., Ltd., and strontium chloride salt is pure water. Strontium chloride hexahydrate commercially available from Chemical Corporation, etc. are mentioned.

Although said (B) component may mix | blend 1 type independently, it is preferable to use 2 types or 3 types together. For example, it is preferable to use a combination of potassium nitrate and aluminum lactate, potassium nitrate and strontium chloride, and among them, combination of potassium nitrate and aluminum lactate is preferable.

As for the compounding quantity of (B) component, 0.1 to 15% of the whole composition, especially 0.3 to 10%, and most preferably 0.5 to 10% is preferable. If it is less than 0.1%, the hypersensitivity relieving effect may not be exhibited, and if it exceeds 15%, the unpleasant taste may be too strong and difficult to use.

In addition, although the compounding quantity of each said perceptual hypersensitivity suppression component can be suitably adjusted within the range of the compounding quantity of the said (B) component, the compounding quantity of potassium nitrate is 0.1-15% of the whole composition, Especially 1-10% is preferable, Less than 0.1% may not exhibit the effect of perceptual hypersensitivity, and stably blend oil phase and water phase containing poorly water-soluble components such as isopropylmethylphenol, perfume components, and the like. An unpleasant taste may become strong by the influence of the mineral salt which affects the state of emulsification and dispersion used for that purpose being small. If it exceeds 15%, the unpleasant taste may be too strong to be used.

As for the compounding quantity of aluminum lactate or strontium chloride, 0.1-10%, especially 0.5-5% of the whole composition are preferable respectively. Less than 0.1% may not exhibit the effect of perceptual hypersensitivity, and the state of emulsification or dispersion used for stably blending an oil phase and an aqueous phase containing poorly water-soluble components such as isopropylmethylphenol and flavoring components. The influence of inorganic salts on the surface may become smaller, and the unpleasant taste may become stronger. If it exceeds 10%, the unpleasant taste may be too strong to be difficult to use.

In the present invention, the blending ratio of the component (B) / (A) is preferably 1 to 1000, particularly 2 to 700, by mass ratio. If (B) / (A) is less than 1, unpleasant taste derived from isopropylmethylphenol may be strongly felt, and if it exceeds 1000, satisfactory biofilm sterilization power cannot be obtained, or unpleasant taste derived from (B) component This feeling is strongly felt and the usability may be inferior.

(C) component is a fragrance component effective in masking the unique unpleasant taste derived from isopropylmethylphenol and (B) component, and is 1 type chosen from 3-octanol, 3-octyl acetate, 3-octanone, and fencone. Or two or more perfume ingredients.

When combining 2 or more types of the said fragrance components, the combination with 3-octanol, 3-octyl acetate, and / or fencone is suitable.

Moreover, even if octanol is a fragrance | flavor which concerns on this invention since 1-octanol which is general as a fragrance | flavor of a dentifrice composition cannot mask the unpleasant origin derived from the target isopropylmethylphenol and (B) component satisfactorily, It is not suitable as a component.

As the component (C), commercially available products may be used. For example, 3-octanol is a product of Shiono Flavor Co., Ltd., 3-octyl acetate and 3-octanone are each a product of Inoue Co., Ltd. Products of Hyangyoung Industry Co., Ltd. can be used.

Although the total compounding quantity of (C) component is not specifically limited, 0.0001 to 0.1%, especially 0.0005 to 0.05%, and most preferably 0.001 to 0.02% are preferable with respect to the composition whole quantity. If the blending amount is less than 0.0001%, the unique unpleasant taste of isopropylmethylphenol and the component (B) cannot be masked, and the usability may be inferior. If the content exceeds 0.1%, the flavor of the perfume component itself is too strong and unpleasant. There may be a taste.

(D) component is an anionic surfactant and / or nonionic surfactant, and can mix | blend 1 type, or 2 or more types. In this case, the anionic surfactant or the nonionic surfactant may be blended alone (mixed only with the anionic surfactant or blended with the nonionic surfactant), or may be used in combination with the anionic surfactant and the nonionic surfactant. , Combinations of anionic surfactants and nonionic surfactants are suitable.

Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosine salts such as sodium lauroyl sarcosine and sodium myristoyl sarcosine, sodium dodecylbenzene sulfonate, and hydrogenated coconut fatty acid mono. N-acyl glutamate, such as sodium glyceride monosulfate, sodium laurylsulfoacetic acid and sodium N-palmitoylglutamate, sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Etc. can be mentioned. Among these, alkyl sulfates, especially alkyl sodium sulfate salts, are preferred from the viewpoint of biofilm sterilization power, solubilization and dispersibility of (A) and (C) components, and suppression of unpleasant taste.

Specifically as an alkyl sulfate, sodium lauryl sulfate is NIKKOL SLS (manufactured by Nikko Chemicals Co., Ltd.), emal 0PT (manufactured by Gao Corporation), TEXAPON OC-P as having a mixed alkyl group of lauryl and myristyl. Commercial items, such as (made by Cognis Japan Ltd.), can be used.

As nonionic surfactant, for example, polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monosthialate, polyoxyethylene polyoxypropylene glycol, alkyl leuco Seed, lauric acid decaglyceryl, etc. are used. Among these, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable from the viewpoint of biofilm sterilizing power, solubilization and dispersibility of (A) and (C) component, and suppression of unpleasant taste.

As polyoxyethylene hardened castor oil, it is preferable that the average added mole number of ethylene oxide is 10-30 mol, especially 10-20 mol from the point that there is no unpleasant taste at the time of use. If it is less than 10 mol, emulsification of a dentifrice composition may become inadequate and the unpleasant taste at the time of use may not be fully suppressed, and what exceeds 30 mol is generally not marketed.

A commercial item can be used for such polyoxyethylene hardened castor oil. For example, NIKKOL HCO-10 (polyoxyethylene (10) hardened castor oil, Nikko Chemicals Co., Ltd.), NIKKOL HCO-20 (polyoxyethylene (20) hardened castor oil, Nikko Chemicals Co., Ltd. product ), NIKKOL HCO-30 (polyoxyethylene (30) hardened castor oil, Nikko Chemicals Co., Ltd.), NIKKOL HCO-40 (polyoxyethylene (40) hardened castor oil, Nikko Chemicals Co., Ltd. product), NIKKOL HCO-60 (polyoxyethylene (60) hardened castor oil, Nikko Chemicals Co., Ltd.), NIKKOL HCO-80 (polyoxyethylene (80) hardened castor oil, Nikko Chemicals Co., Ltd. product), NIKKOL HCO -100 (polyoxyethylene (100) hardened castor oil, Nikko Chemicals Corporation make), etc. are mentioned.

As polyoxyethylene alkyl ether, the average added mole number of ethylene oxide is 3-40 mol, especially 5-20 mol, The thing of 12-18, especially 16-18 carbon atoms of an alkyl group is biofilm bactericidal power, (A) and ( It is preferable at the point of solubilization, dispersibility, and suppression of an unpleasant taste of C) component. Specifically, the average added mole number of ethylene oxide is polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether and the like in the above range.

A commercial item can be used as such a polyoxyethylene alkyl ether. For example, as polyoxyethylene cetyl ether, it is EMALEX103 (polyoxyethylene (3) cetyl ether, Japan Emulsion Co., Ltd. product), EMALEX105 (polyoxyethylene (5) cetyl ether, Japan emulsion Co., Ltd. product), EMALEX107. As polyoxyethylene stearyl ether, such as (polyoxyethylene (7) cetyl ether and the Japan emulsion Co., Ltd. product), EMALEX603 (polyoxyethylene (3) stearyl ether, Japan emulsion Co., Ltd. product), EMALEX605 (poly Oxyethylene (5) stearyl ether, Japan Emulsion Co., Ltd., EMALEX606 (polyoxyethylene (6) stearyl ether, Japan Emulsion Co., Ltd.), EMALEX608 (polyoxyethylene (8) stearyl ether, Japan Emulsion Co., Ltd.), EMAREX620 (polyoxyethylene (20) stearyl ether, Japan Emulsion Co., Ltd.), EMAREX630 (polyoxyethylene (30) stearyl ether, Japan Emulsion Co., Ltd.), EMAREX640 (poly As polyoxyethylene lauryl ether, such as oxyethylene (40) stearyl ether and Nippon Emulsion Co., Ltd., EMAREX705 ( Reoxyethylene (5) lauryl ether, Japan Emulsion Co., Ltd., EMAREX710 (polyoxyethylene (10) lauryl ether, Japan Emulsion Co., Ltd.), EMAREX720 (polyoxyethylene (20) lauryl ether, Nippon Emulsion Co., Ltd. product, EMAREX730 (polyoxyethylene (30) lauryl ether, Nippon Emulsion Co., Ltd. product) etc. are mentioned.

As a combination of an anionic surfactant and a nonionic surfactant, the combination of alkyl sulfate and polyoxyethylene hardened castor oil and / or polyoxyethylene alkyl ether, especially the combination of alkyl sulfate and polyoxyethylene hardened castor oil are suitable among these.

As for the compounding quantity of (D) anionic surfactant and / or nonionic surfactant, 0.1-5%, especially 0.2-3% of the whole composition are suitable. If the blending amount is less than 0.1%, the biofilm sterilization power may be lowered. If the blending amount is more than 5%, the unpleasant taste at the time of use becomes worse and the feeling of use may be inferior.

In addition, in this invention, it is preferable to mix | blend anisealdehyde as (E) component, and to add anisealdehyde in addition to the fragrance component of (C) component, the characteristic unpleasant peculiar to isopropylmethylphenol and (B) component The effect which masks a taste can be heightened more, and it becomes a favorable flavor.

As anise aldehyde, commercial items, such as a product of Ocean fragrance Inc., can be used. The blending amount is preferably 0.0001 to 0.1%, particularly 0.0005 to 0.05%, and most preferably 0.001 to 0.02% based on the total amount of the composition. If the blending amount is less than 0.0001%, the masking effect of the unpleasant taste derived from isopropylmethylphenol and the component (B) may not be sufficiently increased. If the blending amount exceeds 0.1%, the smell of the anisealdehyde itself is too strong, and the unpleasant taste may be caused. It may occur, and may cause a discomfort to a user.

(E) When mix | blending anisealdehyde, the sum total of (C) component and (E) component from the point which raises the masking effect of the unpleasant taste derived from isopropylmethylphenol and (B) component, and improves a flavor more. The compounding quantity can be 0.0002 to 0.15%, especially 0.002 to 0.03%. If the total blending amount is less than 0.0002%, the masking effect of an unpleasant taste may not be sufficiently increased, and if it exceeds 0.2%, the flavor of the components (C) and (E) itself may be too strong, resulting in an unpleasant taste.

Moreover, as a combination of (C) component and (E) component, especially the combination of 3-octanol and anisealdehyde is preferable, and the masking effect especially excellent with respect to unique unpleasant taste is exhibited by this.

The dentifrice composition of the present invention can be formulated and applied as a dentifrice, a liquid dentifrice, and the like, in particular as a dentifrice, and in addition to the above components, other known appropriate ingredients can be blended. Optional components include, for example, viscous agents, caking agents, abrasives, and, if necessary, fragrances, surfactants, active ingredients, pH adjusters, preservatives, sweeteners, colorants, and the like, in a range that does not interfere with the effects of the present invention. It can mix. The composition of this invention can be manufactured by a conventional method by mixing these components and water.

As the viscous agent, one kind or two or more kinds of sugar alcohols such as sorbet, glycerin, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, and reduced starch saccharide and polyhydric alcohol can be blended. As for the compounding quantity of the said viscous agent, 10 to 70% and a liquid dentifrice are preferable in the case of a softening agent with respect to the whole composition.

Examples of the caking agent include cellulose-based binders such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxymethylethyl cellulose, and methyl cellulose, xanthan rubber, carrageenan, guar gum, and alginic acid. Sodium, cationized cellulose, montmorillonite, gelatin, sodium polyacrylate, etc. are mentioned, These can be mix | blended with 1 type (s) or 2 or more types. A compounding quantity is 0.1 to 5% with respect to the whole composition normally.

In addition to the component (C) and, further, the component (E), other flavors such as eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, Peppermint oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, citron oil, sweet oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, celery Oil, bay oil, oliganum oil, pine needle oil, neroli oil, lemon glass oil, rose oil, jasmine oil, patchouli oil, iris concrete, rose absolut, orange flower absolut, vanilla absolut, mango absolut , Natural fragrances such as patchouli solution, ginger oleoresin, pepper oleoresin, capsicum oleoresin, and red pepper extract, and processing of these natural fragrances (current cut, wake cut) , Fractionation, liquid extraction, essence, powdered fragrance, etc.) And, limonene, pinene, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linarool, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol , Anetol, thymol, methylchabicol, eugenol, carbon, menton, pullegon, 1,8-cineol, yonon, charon, n-hexanal, trans-2-hexenal, citral, cinnamic aldehyde, Benzaldehyde, ethyl acetate, ethyl butyrate, isoamyl acetate, hexyl acetate, ethyl2-methylbutylate, arylhexanoate, allylcyclohexanepropionate, linalyl acetate, menthyl acetate, menthyl lactate, carbyl acetate, Phenoxyethyl isobutylate, methyl jasmonate, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol, gamma of 4 to 12 carbon atoms and delta lactone , Ambretolide, dimethyl sulfide, Trimethylpyrazine, ethylβ-methylthiopropionate, praneol, ethylcyclopentenolone, cyclotene, 2-methylbutyric acid, propionic acid, p-methoxycinnamicaldehyde, 3-l-menthoxypropane- Single-flavor fragrances such as 1,2-diol, mentonglycerin acetal, spytolitol, monomenthyl succinate, linalool oxide, vanylylbutyl ether, and isopulegol, and strawberry flavor and apple flavor , Melon flavor, banana flavor, beach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor, plum flavor, orange flavor, lemon flavor, grapefruit flavor Dentifrices such as tea flavors, butter flavors, milk flavors, and fragrance solvents such as ethyl alcohol, propylene glycol, triacetin, and glycerin fatty acid esters. It can be used combining the well-known fragrance | flavor material used for a composition. Although the compounding quantity of these perfume raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for fragrance using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a composition.

As surfactant, in addition to the anionic surfactant and nonionic surfactant of (D) component, you may mix | blend an amphoteric surfactant. As an amphoteric surfactant, for example, lauryl dimethylamino acetic acid betaine, N- palm oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, palm oil fatty acid amidepropyl dimethylamino acetic acid betaine, Palm oil fatty acid amidepropyl betaine etc. are used, but it is not limited to the above. When mix | blending an amphoteric surfactant, the compounding quantity is 0.1 to 5% normally.

As various active ingredients, in addition to (A) isopropylmethylphenol, (B) potassium nitrate, aluminum lactate and strontium chloride, other active ingredients, for example, fluorine compounds such as sodium fluoride, sodium monofluorophosphate and tin fluoride Enzymes such as dextranase, mutanase, water soluble phosphate compounds such as potassium salt of phosphate, sodium salt, tranexamic acid, epsilon-aminocaproic acid, allantoinchlorhydroxyaluminum, hinoki thiol, lauroyl sarcosine Sodium, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azlene, glycyrrhetitin, glycyrrhetinic acid, sodium copper chlorophyllin, chlorophyll, glycerophosphate Copper compounds such as chelating phosphate compounds, copper gluconate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, methoxyethylene anhydride Reic acid copolymer, polyvinylpyrrolidone, epidihydrocholesterine, cetylpyridinium chloride, benzetonium chloride, dihydrocholesterol, trichlorocarvanilide, zinc citrate, sugar extract, chamomile extract, chamomile, cloves And extracts such as rosemary, gold, safflower and the like. In addition, the compounding quantity of these active ingredients can be made an effective amount in the range which does not prevent the effect of this invention.

Examples of the abrasive include silica-based abrasives such as silica gel, aluminosilicate and zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate dihydrate, tribasic calcium phosphate, tetracalcium phosphate, calcium octaphosphate and pyrophosphate Calcium phosphate abrasives such as calcium, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethylmethacrylate, insoluble metaphosphate, hard calcium carbonate, heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, Zirconium silicate, hydroxyapatite, fluoroapatite, calcium-deficient apatite, synthetic resin-based abrasives and the like can be used alone or in combination. The compounding amount is usually 0 to 50%, particularly 5 to 40%, based on the total amount of the composition of the softener, 0 to 30%, especially 2 to 15% of the total amount of the composition of the liquid dentifrice.

As a pH adjuster, 1 type, such as a phthalic acid, phosphoric acid, a citric acid, a succinic acid, an acetic acid, a fumaric acid, a malic acid, a pyrophosphoric acid, a glycerophosphate, and a carbonic acid, their potassium salt, a sodium salt, and an ammonium salt, ribonucleic acid, its salt, and sodium hydroxide, or 2 or more types can be added in a normal amount in the range which does not prevent the effect of this invention.

Examples of the preservative include palaoxybenzoic acid esters such as butyl paraben, propyl paraben, ethyl paraben and methyl paraben, benzoates such as sodium benzoate, potassium sorbate and the like.

Examples of the sweetening agent include sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamicaldehyde, neohepyridinedihydrochalcone, peraryllatin, and the like.

As a coloring agent, Blue No. 1, Yellow No. 4 (FD & C, Yellow No. 5 (19140), Green No. 3, Red No. 105, etc.) are illustrated.

In addition, the compounding quantity of these components can be made into the normal amount in the range which does not prevent the effect of this invention.

As a container, the material of the container accommodated is not restrict | limited, Usually, the container used for a softening agent composition and a liquid dentifrice composition can be used.

Example

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to a following example. In addition, in the following example,% is the mass% unless there is particular description.

[Examples and Comparative Examples]

The dentifrice composition of the composition shown to Tables 1-3 was prepared by the following manufacturing method.

(Manufacturing method)

The preparation of the dentifrice composition was dissolved in purified water and dissolved in water-soluble substances such as sodium saccharin, sodium monofluorophosphate, and sorbitan solution, followed by addition of a solution obtained by dispersing a binder in propylene glycol, followed by stirring. Then, polyoxyethylene hardened castor oil, heat-dissolved polyoxyethylene (5) stearyl ether, a flavoring agent, an abrasive, sodium alkyl sulfate, etc. were added, and it stirred again under reduced pressure (pressure 4kPa), and obtained the dentifrice composition. A unimixer (FM-SR-25, POWEREX CORPORATION) was used for manufacture.

In addition, in preparation of such a dentifrice composition, isopropylmethylphenol (manufactured by Osaka Chemical Co., Ltd.), potassium nitrate (Matsumoto Corporation), aluminum lactate (manufactured by Musashino Chemical Co., Ltd.), strontium chloride (pure chemistry) 3-octanol (manufactured by Shiono Flavor Co., Ltd.), 3-octyl acetate and 3-octanone (manufactured by Inoue Co., Ltd.), Fencon (manufactured by Hyangyoung Industry Co., Ltd.), Anise Aldehyde (made by Ocean fragrance Co., Ltd.), 1-octanol (made by Takasago fragrance industry), sodium lauryl sulfate (made by Nikko Chemicals, NIKKOL SLS), polyoxyethylene (20) hardening caster Freedom (manufactured by Nikko Chemicals Co., Ltd., NIKKOL HCO-20), polyoxyethylene (5) stearyl ether (manufactured by Japan Emulsion Co., Ltd., EMALEX605), silica (Rhodia Chemical Co., Ltd. product, TIXOSIL 73), Sor Beet (product made from Towa Kasei Kogyo Co., Ltd., D-sorbitol solution (70% aqueous solution)), sodium carboxymethyl cellulose (DICEC CHEMICAL CO., LTD., CMC1250) are used, and sodium monofluorophosphate Propylene glycol, sodium saccharin, titanium dioxide, purified water was used as the raw material suitable for quasi-standard 2006.

As for sorbet, a dentifrice composition was prepared using the 70% aqueous solution product. As the fragrance, the fragrance compositions A to I shown in Table 4 were produced and blended using the flavor composition shown in Table 5.

The obtained dentifrice composition is a laminate tube (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / EMAA30 / LDPE20 / LLDPE30) whose innermost layer is composed of linear low density polyethylene (thickness nippon) 50g was filled to the printing.

In the layer structure of the used laminated tube, the symbol and name are as follows, and the number following the symbol shows the thickness (micrometer) of each layer.

LDPE: Low Density Polyethylene

LDPE: White Low Density Polyethylene

LLDPE: Linear Low Density Polyethylene

AL: Aluminum

PET: Polyethylene Terephthalate

EMAA: Copolymer Resin of Ethylene Methacrylic Acid

The following methods evaluated the biofilm sterilization power, the perceptual hypersensitivity inhibitory effect, and the unpleasant taste of the obtained dentifrice composition by the following method. The results are written together in Tables 1-3.

(1) Evaluation method of model biofilm sterilization effect

A hydroxyapatite (HA) plate having a diameter of 7 mm was treated with phosphorus-free stimulant saliva filtered with a 0.45 μm filter for 4 hours, followed by streptococcus mu in tryticase soy broth containing hemin and menadione. Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, and porphyromonas-ginjivalis Model biofilms were formed on the HA plate by continuous incubation for 2 weeks in a 5 strain mixture system of Porphyromonas gingivalis). Once a day after 2 weeks of incubation, the skirt preparation shown in the table below was used as a human saliva (50 mmol / L KCl + 1 mmol / L KH ₂ PO ₄ +1 mmol / L CaCl ₂ +0.1 mmol / L MgCl ₂ (pH7). 2x mass) was added, the centrifugal supernatant after dispersion was used as a test chemical liquid, and the model biofilm was immersed in this for 3 minutes, and cultured again for 3 days. At the end of the cultivation, the model biofilm was taken out, and after dispersion, the biomass of each species in the model biofilm was obtained by culturing on an agar plate. The viable cell number fluctuates somewhat depending on the culture conditions, but when population saliva is applied instead of the test drug solution, it is about 8.5 log cfu (colony forming units / HA version), and less than 6.0 log cfu / HA version. It was judged that biofilm sterilization power was high. In addition, evaluation criteria are shown below.

Model biofilm sterilization effect evaluation criteria

◎: less than 5.0 log cfu / HA version

(Circle): 5.0 log cfu / HA version or more and 6.0 log cfu / HA version or less

△: 6.0 log cfu / HA version or more to less than 7.0 log cfu / HA version

×: 7.0 log cfu / HA version or more

(2) hypersensitivity inhibitory effect

With cold water in the mouth, 10 panelists of sensitized hypersensitivity were used for 4 weeks with the test skirt composition, and then, the test skirt composition filled in the laminate tube was extruded 1 cm onto the toothbrush, and the same method as usual. It brushed for 2 minutes, and evaluated by the evaluation criteria-1 shown below. The average score of 10 people was evaluated by the evaluation criteria-2.

Evaluation criteria-1

5 points | pieces: If I hold cold water in my mouth after brushing teeth, my teeth don't get sore at all.

4 points | pieces: If I hold cold water in my mouth after brushing teeth, my teeth don't get sore

3 points | pieces: If you have cold water in your mouth after brushing your teeth, your teeth will not be sore

2 points | pieces: If you hold cold water in your mouth after brushing your teeth, your teeth will be sore

1 point: After brushing teeth and having cold water in my mouth, my teeth are remarkable.

Evaluation criteria-2

◎: Average score of 10 or more

○: Average score of 10 people is 3.0 or more and less than 4.0

(Triangle | delta): An average score of 10 persons is 2.0 or more and less than 3.0

X: The average score of 10 persons is less than 2.0

(3) evaluation of no unpleasant taste

Sensory tests were conducted using 10 expert panelists. About 1 g of a dentifrice composition was applied to a commercially available toothbrush and brushed for 3 minutes, and the unpleasant taste felt in use was evaluated according to the following ratings. The average value of the evaluation result of ten people was calculated | required, and it was judged that it is a dentifrice composition with no unpleasant taste that the evaluation of (circle) and (circle) was ensured on the following references | standards.

(grade)

4 points | pieces: There is no unpleasant taste at all

3 points | pieces: There is little unpleasant taste.

2 points | pieces: There is a little unpleasant taste.

1 point | piece: There is an unpleasant taste.

(Evaluation standard)

◎: 3.7 or more and 4.0 or less

◎ to ○: 3.3 or more and less than 3.7

(Circle): 3.0 or more and less than 3.3 points

△: 2.0 or more and less than 3.0 points

×: less than 2.0 points

[Table 1-1]

[Table 1-2]

[Table 1-3]

[Table 2]

Table 3-1

Table 3-2

Table 3-3

Table 3-4

From the results of Tables 1 to 3, when any one of the components (A) to (D) is lacking or when the blending amount of these components is inadequate, any of biofilm sterilizing power, hypersensitivity inhibitory action, and no unpleasant taste In contrast to one, the dentifrice composition (Example) of the present invention was found to be excellent in biofilm sterilizing power and hypersensitivity inhibiting action, to have no unpleasant taste, to have good usability, and to combine these excellent characteristics. In Examples 1 to 80, the same results were obtained even when the perfume composition A was replaced with any one of the perfume compositions B to I.

[Table 4]

*: 3-octanol, 3-octyl acetate, 3-organone, phencone, anisealdehyde are not included in the fragrance composition.

Table 5-1

Table 5-2

Table 5-3

Table 5-4

Table 5-5

Table 5-6

Claims (7)

(A) isopropylmethylphenol,
(B) one or two or more selected from potassium nitrate, aluminum lactate, strontium chloride,
(C) one or two or more flavor ingredients selected from 3-octanol, 3-octyl acetate, 3-octanone, fencone,
(D) A dentifrice composition characterized by containing an anionic surfactant and / or nonionic surfactant. The method of claim 1,
The mass ratio of (B) component / (A) component is 2-700, The dentifrice composition characterized by the above-mentioned. 3. The method according to claim 1 or 2,
(D) component is an alkyl sulfate, polyoxyethylene hardened castor oil, and / or polyoxyethylene alkyl ether, The dentifrice composition characterized by the above-mentioned. The method according to claim 1, 2 or 3,
0.01 to 0.2% by mass of component (A), 0.1 to 15% by mass of component (B), 0.0001 to 0.1% by mass of component (C), and 0.1 to 5% by mass of component (D). Dentifrice composition. The method according to any one of claims 1 to 4,
Moreover, (E) dentifrice composition containing anisealdehyde. 6. The method of claim 5,
(E) The dentifrice composition containing 0.0001-0.1 mass% of components. 7. The method according to any one of claims 1 to 6,
Furthermore, the dentifrice composition characterized by mix | blending 10-70 mass% of viscous agents, 0.1-5 mass% of caking additives, and 0-50 mass% of abrasives, and prepared as a softening agent.