JP2009149560A - Oral composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral composition having excellent recalcification promoting effect, not having astringent taste or bitter taste, and giving good feeling in use. <P>SOLUTION: The oral composition contains (A) calcium glycerophosphate, (B) sodium monofluorophosphate, and (C) raffinose and/or melibiose; and the composition is further compounded with (D) anethole and (E) a surfactant and/or an alcohol. The oral composition has high recalcification promoting effect and suppressed astringent taste and bitter taste derived from calcium glycerophosphate and sodium monofluorophosphate, gives good feeling in use, and is effective for the prevention or amelioration of dental caries. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a composition for oral cavity that is excellent in the effect of promoting remineralization, has a good palatability that suppresses astringency and bitterness, and is effective in preventing or reducing caries.

  Dental enamel is mainly composed of hydroxyapatite, and in the oral cavity, in general, elution of phosphate ions and calcium ions (decalcification) and crystallization into calcium phosphate and hydroxyapatite (remineralization) are balanced. It is in a state. When many calcium ions and phosphate ions are present in the oral cavity, the degree of saturation with respect to hydroxyapatite increases, thereby suppressing decalcification and promoting remineralization. Specifically, calcium glycerophosphate is degraded by the phosphatase enzyme in plaque, increasing calcium and phosphate concentration in plaque to promote remineralization, and preventing a significant decrease in plaque pH, It is thought to interfere with the metabolism of Streptococcus mutans (see Patent Document 1). In addition, fluoride ions suppress decalcification in an acidic environment, and in a neutral environment, caries can be prevented by promoting crystallization of calcium ions and phosphate ions, that is, remineralization.

  Conventionally, fluorine has been widely used to prevent caries and has a great track record. Various known techniques for improving the effectiveness of fluorine preparations have been proposed. For example, a mixed aqueous solution (pH 4.5 to 7.0) of a water-soluble calcium salt, a divalent metal salt other than calcium, a water-soluble phosphate and a fluoride is patented as a one-part water-based product for remineralization It is disclosed in Document 1. A technique for blending sodium fluoride, a water-soluble calcium salt and a sugar derivative to form a colloidal fluoride and improving the retention of fluorine (Patent Documents 2 and 3), fluoride, tartaric acid and water-soluble calcium salt And a technique for improving calcium supply (Patent Document 4), and Patent Documents 5 and 6 include sugar alcohols such as abrasive silica and xylitol, calcium ion supply compounds, and fluorine ion supply compounds. A technique has been proposed that mixes, suppresses the formation of calcium fluoride precipitates, promotes remineralization, and improves palatability.

  Patent Document 7 includes a calcium ion supply compound, a monofluorophosphate ion supply compound, lactic acid, malic acid or tartaric acid, and a sugar alcohol, and has a high calcium ion residual rate of pH 4 to 6.2. Oral compositions have been proposed. Patent Document 8 proposes a multi-composition system composed of a first composition containing a calcium ion supply compound and a second composition containing a fluorine ion supply compound, and malate ion supply compound and monofluorophosphate ion. An oral composition formulated in combination with a delivery compound is disclosed.

  As seen in the above-mentioned known literature, fluoride is also important for preventing or reducing caries, but most of the enamel is composed of hydroxyapatite and promotes remineralization. From the viewpoint, it is also important to supply calcium ions and phosphate ions. Fluorine ion supply compounds and calcium ion supply compounds are blended into the oral composition, and sugar alcohols are blended to provide a remineralization effect. Proposals to promote it have also been made.

  However, even in these techniques, it is difficult to say that the remineralization promoting strength and the taste of the composition are sufficient, and the oral composition has a higher remineralization effect and excellent usability. There is a strong demand for the development of technology that can provide products.

Japanese National Patent Publication No. 10-511104 Japanese Patent Laid-Open No. 03-72415 Japanese Patent Laid-Open No. 06-298631 Japanese Patent Publication No. 08-32619 JP 11-49653 A JP-A-11-106322 JP 2005-206592 A JP 2006-69990 A

  This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity which is excellent in the acceleration | stimulation effect of remineralization, has no astringency and bitterness, and has a favorable usability.

  As a result of intensive studies to achieve the above object, the present inventors have obtained a high remineralization effect by blending calcium glycerophosphate, sodium monofluorophosphate, raffinose and / or melibiose. The astringency and bitterness derived from calcium glycerophosphate and sodium monofluorophosphate are reduced, and a good feeling of use is obtained. Furthermore, by blending anethole with a surfactant and / or alcohol, astringency -It discovered that bitterness was reduced further and the composition for oral cavity which was excellent with the acceleration | stimulation effect of remineralization can be obtained, and it came to make this invention.

  That is, as can be seen from the experimental examples described later, when a combination of calcium glycerophosphate and sodium monofluorophosphate is added, the astringency and bitterness are produced when the amount is increased in order to promote remineralization. It is difficult to exhibit a high remineralization effect. On the other hand, according to the present invention, by using the oligosaccharide raffinose and / or melibiose in combination with calcium glycerophosphate and sodium monofluorophosphate, these components act synergistically and have a high remineralization effect. And astringency and bitterness derived from calcium glycerophosphate and sodium monofluorophosphate are also suppressed, and it has both excellent remineralization promoting effect and good usability. By blending an activator and / or alcohol, these effects are further improved.

  Accordingly, the present invention provides an oral composition comprising (A) calcium glycerophosphate, (B) sodium monofluorophosphate, and (C) raffinose and / or melibiose, The above oral composition containing D) anethole and (E) a surfactant and / or alcohol is provided.

  The composition for oral cavity of the present invention has a high remineralization promoting effect, suppresses astringency and bitterness derived from calcium glycerophosphate and sodium monofluorophosphate, has a good feeling of use, and prevents or reduces caries. It is valid.

  Hereinafter, the present invention will be described in further detail. The oral composition of the present invention contains (A) calcium glycerophosphate, (B) sodium monofluorophosphate, and (C) contains raffinose and / or melibiose. .

As calcium glycerophosphate, a commercially available product can be used, and “calcium glycerophosphate” manufactured by Iwaki Pharmaceutical Co., Ltd. can be exemplified.
The blending amount of calcium glycerophosphate is preferably 0.01 to 5.0% (mass%, the same shall apply hereinafter), particularly 0.1 to 3.0%, particularly 0.3 to 2.0% of the entire composition. When the blending amount is less than 0.01%, a sufficient remineralization effect may not be obtained, and when it exceeds 5.0%, astringency and bitterness may be felt and the feeling of use may be insufficient. .

  A commercially available product can be used as sodium monofluorophosphate, and examples include “Sodium Monofluorphosphate” by Albright & Wilson UK Limited.

  The blending amount of sodium monofluorophosphate is preferably 0.01 to 2.0% of the total composition, more preferably 0.01 to 1.0%, and still more preferably 0.1 to 0.8%. . When the amount is less than 0.01%, a sufficient remineralization effect may not be obtained, and when it exceeds 2.0%, astringency and bitterness may occur.

  In the present invention, raffinose and / or melibiose is blended. Raffinose is a trisaccharide composed of one molecule each of D-galactose, D-glucose and D-fructose, in which galactose is bound to sucrose, and can be obtained by separation and purification from beet (sugar radish). It is a natural oligosaccharide. Melibiose is a disaccharide composed of one molecule each of D-galactose and D-glucose, and raffinose is decomposed into melibiose and fructose by heating raffinose or by reacting raffinose with invertase or dilute acid. Obtained. In the present invention, by combining raffinose and / or melibiose among oligosaccharides, an excellent remineralization effect and an astringent / bitter taste suppressing effect can be obtained. Raffinose, melibiose D-galactose, D-glucose It is thought that this part greatly contributes to the improvement of the remineralization effect and the suppression of astringency and bitterness.

  In the present invention, raffinose and melibiose can use commercially available products. As raffinose, “Nitten raffinose” manufactured by Nippon Sugar Sugar Co., Ltd., “Meiji Beat Oligo”, “Meiji Beat Oligo FP” manufactured by Meiji Food Materia Co., Ltd. Commercially available reagents from Wako Pure Chemical Industries, Ltd. can be used.

In the present invention, either raffinose or melibiose may be used alone, or both components may be used in combination. The total amount of raffinose and / or melibiose is 0.1 to 30%, particularly 1 to 20%, especially 1 to 10% of the whole composition, and sufficient remineralization effect if less than 0.1%. In some cases, the effect of suppressing astringency and bitterness may not be obtained, and if it exceeds 30%, the sweetness of the oral composition may become too strong.
In addition, the blending amount of raffinose is preferably 0.1 to 20%, particularly 1 to 15%, particularly 1 to 10%. The blending amount of melibiose is 0.1 to 30%, particularly 1 to 20%, particularly 1 to 10%.

In the present invention, the total amount of (C) raffinose and / or melibiose with respect to the total amount of (A) calcium glycerophosphate and (B) sodium monofluorophosphate ((C) / ((A) + (B ))) Is preferably 1 or more, particularly 2 to 20, particularly 2 to 15 in terms of mass ratio, and by blending at such a ratio, a higher remineralization effect is exhibited and astringency・ Bitterness is also sufficiently suppressed.
In addition, when it does not contain anethole, (C) / ((A) + (B)) is 2 or more, particularly 5-20, especially 5-15, and when it contains anethole, (C) / ((A) + (B)) is preferably 1 or more, in particular 2 to 20, in particular 2 to 10.

  It is preferable to further blend (D) anethole into the composition of the present invention, and by blending these components, a more excellent remineralization effect and an astringent taste / bitter taste suppressing effect can be obtained.

Anethole (trans-1-methoxy-4- (prop-1-en-1-yl) benzene) is the main component of anise oil (containing 50-80% anethole) and is insoluble in water, A fragrance that is soluble in a surfactant and / or alcohol.
In the present invention, as anethole, anethole commercially available as a reagent from Wako Pure Chemical Industries, Ltd. may be used, or anise oil (for example, manufactured by Koei Kogyo Co., Ltd.) may be used as it is.

  The blending amount of anethole is preferably 0.01 to 2.0%, particularly 0.1 to 1.0%, especially 0.2 to 1.0% of the whole composition. If the blending amount is less than 0.01%, the astringency / bitter taste suppressing effect may not be sufficiently exhibited, and if it exceeds 2.0%, the flavor of the oral composition may become too strong.

  Since anethole does not dissolve in water, when blending anethole, (E) a surfactant and / or alcohol is blended together. In this case, the surfactant may be blended alone or the alcohol may be blended alone, or the surfactant and the alcohol may be blended in combination, and they are appropriately selected according to the dosage form and the like. For example, surfactants and alcohols are used in dentifrice compositions, and alcohol alone or in combination with surfactants and / or alcohols in mouthwash compositions.

As the surfactant, one or more selected from anionic surfactants, nonionic surfactants and zwitterionic surfactants may be blended.
Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzene sulfonate, Hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, α-olefin Sodium sulfonate, sodium dioctyl sulfosuccinate and the like are used.

  Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, polyoxyethylene sorbitan monolaurate, poly Polyoxyethylene fatty acid esters such as polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, fatty acid diethanolamides such as lauric acid mono or diethanolamide, myristic acid mono or diethanolamide, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxy Ethylene hydrogenated castor oil, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene Polyoxypropylene fatty acid ester or the like is used.

  As the zwitterionic surfactant, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, 2-alkyl-1-hydroxyethylimidazoline One or more kinds of betaine sodium, N-alkyl-lauryldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium, etc. It is possible to mix.

Surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, anionic surfactants such as sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, and average addition of ethylene oxide. A polyethylene glycol type nonionic surfactant such as polyoxyethylene hydrogenated castor oil having a mole number of 20 to 100 mol is preferred.
When mix | blending these surfactant, the compounding quantity is 0.1 to 10% of the whole composition, Especially 0.2 to 5% is preferable.

As the alcohol, a monohydric alcohol and / or a polyhydric alcohol having a solubilizing power with respect to anethole can be blended. For example, C2-C4 monohydric alcohols such as ethanol, isopropanol, butanol, propanol, etc., glycerin, ethylene glycol, diethylene glycol, hexylene glycol, propylene glycol, butylene glycol, pentanediol, polyhydric alcohols such as polyethylene glycol 200-400 It is possible to blend one or more of these. Of these, ethanol, glycerin, propylene glycol, and polyethylene glycol 200, 300, and 400 are preferable.
When the alcohol is blended, the blending amount is preferably 1 to 40%, particularly 2 to 20% of the entire composition.

  In addition, when mix | blending surfactant and / or alcohol, the total compounding quantity is 0.1 to 50% of the whole composition, and 0.5 to 40% is especially preferable.

  The composition for oral cavity according to the present invention can be made into various forms such as solid, solid, liquid, liquid, gel, paste, gum and the like, such as toothpaste, liquid toothpaste, liquid toothpaste, and toothpaste. It can be prepared in various dosage forms such as a dentifrice, mouthwash, mouthwash, and freshener in the mouth, and is particularly suitable as a toothpaste. As the production method, a conventional method according to the dosage form can be adopted, and depending on the purpose, the dosage form of the composition, etc., in addition to the above components, other appropriate components are further blended. can do. Specifically, in the case of mouthwashes, dentifrices, and mouth fresheners, binders, sweeteners, fragrances, coloring agents, preservatives, active ingredients, etc., and dentifrices additionally contain abrasives, thickeners, etc. It can be used in a normal amount as long as the effects of the present invention are not hindered.

  Specifically, in the case of dentifrice, for example, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate. Aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, synthetic resin-based abrasive and the like are preferably used. The blending amount of these abrasives is preferably 2 to 40%, particularly 10 to 30% of the entire composition.

  In the case of dentifrice, it is possible to mix sugar alcohols such as sorbit, polyethylene glycol 1000 to 20000, etc. as a thickening agent, and the blending amount is preferably 1 to 50%, particularly 2 to 40% of the whole composition. .

  As the binder, one or more of sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, carbopol, guar gum, montmorillonite, gelatin and the like can be blended. Although the compounding quantity of a binder can be adjusted with a dosage form, it is 0.1 to 5% for toothpaste, and can be 0 to 5% for liquid dosage forms, such as a liquid toothpaste and a mouthwash.

  Sweeteners other than raffinose and melibiose, such as saccharin sodium, erythritol, xylitol, lactitol, maltitol, mannitol, palatinose, reduced palatinose (palatinite), thaumatin, aspartame, acesulfame K, cyclamate sodium, stevioside, stevia extract , Paramethoxycinnamic aldehyde, neohesberyl dihydrochalcone, perilartin, p-methoxycinnamic aldehyde, trehalose, palatinose, palatinit, soybean oligosaccharide, dairy oligosaccharide, xylooligosaccharide, L-aspartyl-L-phenylalanine methyl ester, sucralose 1 type, or 2 or more types, such as glycyrrhizin, can be blended within a range not impeding the effects of the present invention.

As a preservative, it is possible to mix | blend 1 type (s) or 2 or more types, such as p-hydroxybenzoic acid ester, benzoic acid, and a benzoate.
Examples of the colorant include blue No. 1, yellow No. 4, green No. 3, and the like.

  In addition, various organic acids that can be usually blended in oral compositions can be used. Examples of organic acids include citric acid, isocitric acid, malic acid, acetic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, maleic acid. , Fumaric acid, aconitic acid, lactic acid, tartaric acid, pyruvic acid, ascorbic acid, glycolic acid or salts thereof. Among these, citric acid, malic acid, tartaric acid, lactic acid, or salts thereof are particularly suitable, and one or more can be blended.

  As medicinal ingredients, in addition to sodium monofluorophosphate and calcium glycerophosphate, other active ingredients such as sodium azulenesulfonate, ε-aminocaproic acid, allantoin, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, epidihydrocholesterin, dihydro Cholesterol, sodium chloride, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, isopropylmethylphenol, cetylpyridinium chloride, decalinium chloride, chloride Benzalkonium, benzethonium chloride, alkyldiaminoethylglycine hydrochloride, chlorhydrochloride Hexidine, triclosan, ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, zeolite, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, monophosphate Sodium hydrogen, trisodium phosphate, sodium polyphosphate, sodium fluoride, tin fluoride, polyvinylpyrrolidone, polyvinylpyrrolidone K25, polyvinylpyrrolidone K30, polyvinylpyrrolidone K90, lysozyme chloride, copper chlorophyllin sodium, hinokitiol, tranexamic acid, dextranase Aluminum lactate, potassium nitrate, protease and the like can be blended according to the purpose. The compounding quantity of the said medicinal component can be made into an effective quantity in the range which does not prevent the effect of this invention (mixing quantity usually 0.001 to 5%).

  As perfumes, peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil in addition to anethole and anise oil , Mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, Natural fragrances such as grapefruit oil, sweetie oil, straw oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractionation, essence, powder Perfume and men) Alcohol, carvone, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentane -3-Carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone , Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethylthio For oral compositions such as single flavors such as cetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The known perfume materials used can be used in combination.

  EXAMPLES Hereinafter, although an experiment example and an Example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% of the blending amount is mass%.

[Experimental example]
About the test solution which mix | blended the chemical | medical agent, the remineralization effect and the intensity of astringency and bitterness were evaluated by the following method.

<Evaluation of remineralization effect>
The following experiment was conducted according to the method described in Journal of Oral Hygiene 54: 2-8, 2004.
Preparation of decalcified sample:
Divide the enamel part of the bovine teeth into a cross with a hard tissue cutting machine MICRO CUTTER (MC-201 Marto), make 4 enamel blocks from 1 tooth, and select a total of 100 blocks (5 per group) did. The enamel surfaces of these blocks were mirror-polished and coated with nail enamel so that an approximately 4 × 4 mm window was exposed. One block was immersed in 10 ml of a decalcification solution having the composition shown in Table 1 and allowed to stand at 37 ° C. for 3 days to form an artificial surface demineralized lesion. Five of the 100 samples were used as a baseline (decalcification treatment only) for comparison.

Remineralization treatment:
A test solution having the composition shown in Table 2 was diluted 3-fold with distilled water (test solution: distilled water (mass ratio) = 1: 2), and the decalcified sample (each group 5 enamel block) was 1 It was immersed for 5 minutes at room temperature twice a day (around 9 o'clock and 18 o'clock) one block at a time. The decalcified sample after immersion was cleaned for about 30 seconds under running tap water after cleaning the window surface for about 10 strokes with a toothbrush (PC CLINICA ION HABASH STANDARD LION Co., Ltd.). It was immersed in 10 ml of the remineralization solution having the composition shown in Table 1 and maintained at 37 ° C. This remineralization solution is similar to the plaque fluid composition 30 minutes after ingestion of sucrose and is supplemented with acid phosphatase having MFPase activity (derived from P-3627 wheat). . This series of operations continued for 14 days.

Measurement of mineral loss by Transverse Microradiography (TMR):
The sample after decalcification and after the remineralization treatment was dehydrated, embedded and cured using a resin (Rigolac 70F, Rigolac 2004; Ohken Shoji Co., Ltd.). After cutting with MICRO CUTTER (MC-201 Marto), it was polished, and a section having a thickness of about 110 μm passing through the window portion was produced. Aluminum sections for each section and calibration curve were arranged on a photoplate, and irradiated with X-rays under the conditions of a current of 3 mA, a voltage of 10 kV, and an irradiation time of 10 minutes to obtain a microscopic radiograph (TMR image). Using an image analyzer (PIAS-V, PIAS), the mineral density from the enamel surface of the TMR image toward the deep layer was analyzed. Mineral density of the background and healthy enamel was set to 0 and 100%, and the mineral loss amount (ΔZ; vol% · μm) of the polished slice sample was measured and calculated from these mineral concentration profiles (in each group n = 5) Measured average). The smaller the amount of mineral loss, the smaller the amount of demineralization and the higher the remineralization effect.

<Sensory evaluation method>
About the test solution which melt | dissolved the chemical | medical agent shown in Table 2 in distilled water, sensory evaluation of the strength of astringency and bitterness was carried out by 10 test subjects (8 men, 2 women), and evaluated according to the following evaluation criteria. Distilled water was used as a control, and each drug was subjected to sensory evaluation with the astringency and bitterness of distilled water as 5 points. The result was shown by the average value of the scores of 10 subjects.

Evaluation criteria 5: No astringency or bitterness 4: Level of almost no astringency or bitterness 3: Slight astringency or bitterness 2: Slightly astringent or bitterness 1: Astringency・ Strong bitterness

Anethole: Wako Pure Chemical Industries, Ltd.
l-Carvone: Sigma Aldrich Japan Co., Ltd.
l-Menthol: Wako Pure Chemical Industries, Ltd.
Trehalose: Hayashibara Shoji Co., Ltd. “Treha”
Maltose: Hayashibara Shoji "Fine Toe"

From the results in Table 2, when a combination of calcium glycerophosphate and sodium monofluorophosphate and raffinose and / or melibiose is combined, the remineralization effect is enhanced, and the astringency derived from calcium glycerophosphate and sodium monofluorophosphate. -It was confirmed that bitterness was improved (experimental example). On the other hand, when any of the essential requirements of the present invention was lacking, the remineralization effect was not improved, and the astringency and bitterness were not improved (Comparative Experimental Example). As is clear from the results of Comparative Experimental Examples 2 and 4, trehalose and maltose were hardly observed to improve the astringency and bitterness derived from calcium glycerophosphate and sodium monofluorophosphate.
Furthermore, it was confirmed that by adding anethole, it is possible to provide a composition for oral cavity that is more excellent in remineralization effect, excellent in caries reduction and prevention effect, and has a good feeling of use (Experimental Example 9). ).

  Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

[Example 1] Toothpaste silica 20.0%
Propylene glycol 3.0
Glycerin 25.0
Sodium carboxymethylcellulose 1.4
Calcium glycerophosphate 0.5
Sodium monofluorophosphate 0.76
Raffinose 5.0
Erythritol 2.0
Sodium lauryl sulfate 1.2
Sodium N-lauroyl sarcosinate 0.1
Saccharin sodium 0.1
Methylparaben 0.1
Sodium fluoride 0.21
Fragrance 0.8
Purified water balance
Total 100.0%

[Example 2] Toothpaste aluminum hydroxide 42.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Calcium glycerophosphate 0.4
Sodium monofluorophosphate 0.8
Raffinose 5.0
Melibiose 2.0
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Anethole 0.1
Purified water balance
Total 100.0%

[Example 3] Toothpaste heavy calcium carbonate 25.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Calcium glycerophosphate 2.0
Sodium monofluorophosphate 0.3
Melibiose 25
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 4] Toothpaste silica 15.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Calcium glycerophosphate 1.2
Sodium monofluorophosphate 0.08
Raffinose 15.0
Palatinose 2.5
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Purified water balance
Total 100.0%

[Example 5] Toothpaste dicalcium phosphate 40.0%
Propylene glycol 3.0
70% sorbit 25.0
Sodium carboxymethylcellulose 1.2
Calcium glycerophosphate 3.0
Sodium monofluorophosphate 0.35
Raffinose 2.0
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Butylparaben 0.02
Fragrance 1.0
Anethole 0.3
Purified water balance
Total 100.0%

[Example 6] Toothpaste silica 20.0%
Propylene glycol 3.0
Glycerin 25.0
Sodium carboxymethylcellulose 1.4
Calcium glycerophosphate 0.5
Sodium monofluorophosphate 0.76
Raffinose 5.0
Melibiose 2.0
Erythritol 2.0
Sodium lauryl sulfate 1.2
Saccharin sodium 0.1
Methylparaben 0.1
Sodium fluoride 0.21
Fragrance 0.8
l-Menthol 0.1
Purified water balance
Total 100.0%

[Example 7] Mouthwash glycerin 5.0%
Ethanol 8.0
Calcium glycerophosphate 1.2
Sodium monofluorophosphate 1.2
Polyoxyethylene hydrogenated castor oil (100 EO) 0.8
Raffinose 3.0
Melibiose 12.0
Erythritol 5.0
Sodium citrate 0.1
Citric acid 0.3
Sodium benzoate 0.5
Fragrance 0.2
Anethole 0.2
Purified water balance
Total 100.0%

[Example 8] Mouth freshener glycerin 13.0%
Ethanol 40.0
Polyoxyethylene hydrogenated castor oil (60 EO) 3.0
Calcium glycerophosphate 0.2
Sodium monofluorophosphate 0.6
Raffinose 1.0
Reduced palatinose 1.5
Xylitol 2.0
Sodium citrate 0.1
Citric acid 0.03
Fragrance 0.4
l-Menthol 0.5
Purified water balance
Total 100.0%

  The oral compositions of these examples were all excellent in the remineralization effect of surface layered decalcification, excellent in the astringency and bitterness suppressing effects of calcium glycerophosphate and sodium monofluorophosphate, and had a good feeling in use. .

Claims (2)

  An oral composition comprising (A) calcium glycerophosphate, (B) sodium monofluorophosphate, and (C) raffinose and / or melibiose.   The composition for oral cavity according to claim 1, further comprising (D) anethole and (E) a surfactant and / or an alcohol.