JP2010143842A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition which stably contains dextranase without losing its enzyme activity over a long period of time, is excellent in foamability and sense of use and exhibits little unusual taste and bitterness so as to offer refreshing sensation after use. <P>SOLUTION: The dentifrice composition comprises (A) dextranase, (B) sodium chondroitin sulfate and (C) coconut oil fatty acid amidopropyl betaine, wherein the amounts of (B) sodium chondroitin sulfate and (C) coconut oil fatty acid amidopropyl betaine compounded in the dentifrice composition are 0.1-3.0 mass% and 0.1-1.0 mass%, respectively, and the mass ratio of component (C) to component (B) is 0.1-3.0. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a dentifrice composition having high storage stability over time of dextranase in a preparation, excellent foaming, little off-taste and excellent refreshing feeling after use.

  Dextranase exhibits a caries prevention effect by decomposing plaque, and is therefore blended in the oral composition as an active ingredient.

  On the other hand, surfactants are blended in the oral composition from the viewpoint of usability and usability, and in particular, a large amount of abrasive is blended in the dentifrice composition, ensuring sufficient foamability. Therefore, an anionic surfactant such as sodium lauryl sulfate is blended. However, a dentifrice composition containing many anionic surfactants has a drawback that it is difficult to maintain the temporal stability of the enzyme due to its protein-denaturing action. In a dentifrice composition containing dextranase, However, the problem was the decrease in the stability of dextranase over time.

  For this reason, in dentifrice compositions containing dextranase, a technique for stabilizing dextranase in the preparation is indispensable. For stabilization, specific non-anionic surfactants such as polyoxyethylene alkyl ether Is known to be useful (Patent Document 1; Japanese Patent Laid-Open No. 61-176518).

  However, with these technical means, the protein denaturation action by anionic surfactants may be improved to some extent, but when a large amount of nonionic surfactant is added, a unique taste and stickiness of the preparation occur. From the above, there is a problem that the dispersibility in the oral cavity cannot be sufficiently secured, and the oral cavity after use, which is required for a dentifrice, cannot be sufficiently obtained. It was not satisfactory.

  Further, in the oral composition containing glucanase and sodium lauryl sulfate, as a method for providing a dentifrice composition capable of ensuring enzyme stability while ensuring a good foaming amount of sodium lauryl sulfate, Polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and 3 to 8 addition moles of ethylene oxide in the agent composition, and polyoxyethylene having 10 to 80 addition moles of ethylene oxide A technique for preliminarily mixing and dispersing hardened castor oil (Patent Document 2; JP-A-2005-41787) has been proposed. However, in the above technical means, although the feeling of use is improved by ensuring foamability, the stickiness peculiar to nonionic surfactants cannot be reduced, and it is insufficient for obtaining a refreshing feeling in the oral cavity. there were.

  On the other hand, sodium chondroitin sulfate has a wide biodistribution among mucopolysaccharides and is known to be contained in hard tissues such as articular cartilage and bone. In addition, in the oral composition, a technique for blending sodium chondroitin sulfate for the purpose of reducing the irritation of the preparation is proposed as a binder (Patent Document 3; JP-A-2006-8651). (Patent Document 4; JP 2007-176802 A). However, these techniques do not show that the stickiness unique to nonionic surfactants is reduced by the addition of chondroitin sodium sulfate, and the refreshing feeling after using the dentifrice is increased.

  In addition, amphoteric surfactants are used in various fields as foaming agents because they are less irritating to the skin and eyes and have a high foaming power and foam stability. Also in the oral cavity field, it has a stimulating and relaxing action in the mouth (Patent Document 5; Japanese Patent Laid-Open No. 57-171909) and an effect of suppressing reattachment of plaque on the tooth surface (Patent Document 6; Japanese Patent Laid-Open No. 2007-2007). 145740) is known. However, these technologies do not show that among the amphoteric surfactants, coconut oil fatty acid amidopropyl betaine has an effect of enhancing the storage stability of dextranase and enhancing the refreshing feeling in the mouth.

  In the dentifrice composition containing dextranase as described above, it has been difficult to satisfy both the storage stability of dextranase over time and the refreshing feeling in the mouth. Accordingly, there has been a demand for the development of a dentifrice composition that can stably maintain the enzyme activity of dextranase over time, has excellent foaming, has a little off-taste, and has a refreshing feeling after use.

JP-A 61-176518 JP 2005-41787 A JP 20068651 A JP 2007-176802 A Japanese Patent Laid-Open No. 57-171909 JP 2007-145740 A

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition having high storage stability over time of dextranase in a preparation, excellent foaming, little off-taste and excellent refreshing feeling after use. The purpose is to do.

  As a result of intensive studies to achieve the above object, the present inventor has (B) chondroitin sulfate and (C) coconut oil fatty acid amidopropyl betaine added to a dentifrice composition containing (A) dextranase. Combined, 0.1-3.0% by mass of the component (B) and 0.1-1.0% by mass of the component (C), so that the dextranase was excellently preserved over time in the dentifrice formulation. It was found that the stability was obtained, the foam had excellent foaming, had a good feeling of use with almost no off-flavor and bitterness derived from the surfactant, and a refreshing feeling in the oral cavity was also improved. It came to make.

  As a result of earnest research to achieve both stabilization of dextranase over time in a dentifrice composition and a refreshing sensation in the mouth, dextranase has sodium chondroitin sulfate, coconut oil fatty acid amidopropyl betaine and As is apparent from the examples described later, these components act synergistically, and the enzyme activity of dextranase is hardly inactivated even after long-term storage. In addition, dextranase can be remarkably stably blended in dentifrice preparations, and even if an anionic surfactant such as sodium lauryl sulfate is blended, it can be blended stably, and the taste and bitterness derived from the surfactant are almost felt. It was possible to achieve a special effect that the feeling of use was good and the feeling of refreshing in the oral cavity after brushing was high. Such effects of the present invention are considered to be derived from the dextranase stabilizing effect of coconut oil fatty acid amidopropyl betaine and the water retention effect of sodium chondroitin sulfate, and can be achieved when any of the components is lacking. In addition, it is impossible to use amidopropyl betaine with raw materials other than coconut oil fatty acid in combination with sodium chondroitin sulfate.

  The applicant uses sodium chondroitin sulfate in combination with dextranase, and further has an average added mole number of ethylene oxide of 40 to 100 moles of polyoxyethylene hydrogenated castor oil and / or an alkyl chain having a carbon chain length of 16 to 18. In addition, Japanese Patent Application No. 2007-216139 proposed a technique in which polyoxyethylene alkyl ether having an average addition mole number of ethylene oxide of 10 to 40 moles was selectively combined in a specific ratio, which was formulated with dextranase. In the liquid oral composition, the synergistic effect of the above-mentioned combined components increases the effect of inhibiting the formation of dextranase-derived plaque, and allows the user to effectively feel the smooth surface of the tooth surface after use. It is possible to suppress the occurrence of orientation over time and maintain good appearance stability. Formed both different technical idea.

Accordingly, the present invention provides the following dentifrice composition.
[Claim 1] (A) containing dextranase, (B) sodium chondroitin sulfate, and (C) coconut oil fatty acid amidopropyl betaine, wherein (B) the amount of sodium chondroitin sulfate is 0.1 to 3.0 mass %, (C) The dentifrice composition characterized by the compounding quantity of coconut oil fatty-acid amide propyl betaine being 0.1-1.0 mass%.
[2] The dentifrice composition according to [1], wherein the mass ratio of component (C) / component (B) is 0.1 to 3.0.

  The dentifrice composition of the present invention has a stable blend of enzyme activity of dextranase over a long period of time, is excellent in foaming, has little off-taste, and has a refreshing feeling after use by suppressing bitterness, usability Is excellent.

  Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is prepared in a paste form, liquid form, etc., and is preferably prepared as a dentifrice such as toothpaste and liquid toothpaste, particularly as a paste form toothpaste. It contains (A) dextranase, (B) sodium chondroitin sulfate, and (C) coconut oil fatty acid amidopropyl betaine.

  (A) As the dextranase, a dextranase obtained by a known method from a known dextranase-producing bacterium belonging to the genus Ketomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, Servibrio, etc. is suitable. However, dextranase produced from other microorganisms can also be used, and commercially available products such as those manufactured by Daiichi Sankyo Propharma Co., Ltd. can be used.

  The blending amount of dextranase is preferably 2 to 200 units / g (U / g), particularly 10 to 50 units / g in the composition. If it is less than 2 units / g, a sufficient plaque removing effect cannot be obtained, and the cleaning feeling after brushing may be inferior. If it exceeds 200 units / g, the stability may not be sufficient. Here, 1 unit of dextranase is the amount of dextranase that produces free reducing sugar corresponding to 1 μmol of glucose per minute when the reaction is carried out using dextran as a substrate. Usually, when 13000 units / g is used, the blending amount of dextranase is preferably 0.0154 to 1.54% (mass%, the same applies hereinafter) of the entire composition.

  (B) As a chondroitin sulfate sodium salt, a commercial item can be used, for example, a commercial item which can be obtained from reagent makers, such as Wako Pure Chemical Industries Ltd. and Tokyo Chemical Industry Co., Ltd., can be used.

  The compounding quantity of chondroitin sodium sulfate is 0.1 to 3.0% of the whole composition, and 0.3 to 2.0% is particularly preferable. If the blending amount is less than 0.1%, a sufficient refreshing feeling cannot be obtained.

  (C) Coconut oil fatty acid amidopropyl betaine is amidopropyl betaine made from palm oil fatty acid containing saturated fatty acids such as lauric acid, myristic acid, and palmitic acid. For example, TEGO Betaine CK OK (30% aqueous solution manufactured by Degussa) ), Commercially available products such as Ahtoal 55AB (30% aqueous solution) manufactured by Kao Corporation. Instead of coconut oil fatty acid amide propyl betaine, using amide propyl betaine other than coconut oil fatty acid as a raw material, such as lauric acid amide propyl betaine, may cause bitterness and poor taste. A refreshing feeling cannot be obtained and the object of the present invention cannot be achieved.

  The blending amount of the coconut oil fatty acid amidopropyl betaine is 0.1 to 1.0% of the whole composition in terms of pure content, and particularly preferably 0.2 to 0.8%. If the blending amount is less than 0.1%, foaming is poor and sufficient refreshing feeling cannot be obtained, and the dextranase stability is inferior.

  The mass ratio ((C) / (B)) of (C) coconut oil fatty acid amidopropyl betaine and (B) sodium chondroitin sulfate is 0.1 to 3.0, particularly 0.3 to 2.0. From the viewpoints of dextranase stability, a refreshing feeling after use, and good taste. If (C) / (B) is less than 0.1, foaming may be poor and the refreshing feeling may be inferior, and if it exceeds 3.0, the taste may be deteriorated.

  In the dentifrice composition of the present invention, in addition to the above essential components, other additives can be blended as optional components depending on the dosage form as long as the effects of the present invention are not impaired. For example, when preparing a toothpaste, abrasives, thickeners, binders, surfactants, and if necessary, sweeteners, preservatives, active ingredients, colorants (pigments), fragrances, etc. can be blended. A component and water can be mixed and manufactured by a conventional method.

  Examples of the abrasive include dicalcium phosphate dihydrate, anhydrous dibasic calcium phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light carbonate Calcium, heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, quaternary calcium phosphate, eighth calcium phosphate, synthetic resin Examples thereof include system abrasives, precipitated silica, silica gel, aluminosilicate, and zirconosilicate. 5-50% of the whole composition is suitable for the compounding quantity of these abrasive | polishing agents.

  As the thickening agent, at least one of glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, polyvalent alcohol such as reduced starch saccharified product, and the like can be used. Usually, the compounding quantity of these thickeners is 10 to 40% of the whole composition.

  As a binder, in addition to chondroitin sodium sulfate, other binders can be added as long as the effects of the present invention are not hindered. For example, organic binders such as sodium alginate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, carrageenan, xanthan gum, carbopol, guar gum, gelatin, crystalline cellulose, montmorillonite, kaolin, bentonite, etc. And inorganic binders. Usually, the blending amount of these other binders is 0.5 to 3% of the entire composition.

  As the surfactant, in addition to the coconut oil fatty acid amidopropyl betaine, other surfactants can be added as long as the effects of the present invention are not hindered. For example, examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, lauroyl sarcosine salt, myristyl sarcosine salt, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, α-olefin sulfonate, and the like. . Nonionic surfactants include, for example, alkyl glycosides having 8 to 16 carbon atoms in the alkyl group, sucrose fatty acid esters having 12 to 18 carbon atoms in the fatty acid group such as sucrose mono or dilaurate, lactose fatty acid esters, Polyalkyl alcohol fatty acid esters such as lactitol fatty acid ester, maltitol fatty acid ester and stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, and alkyl such as lauroyl diethanolamide Roylethanolamide, polyoxyethylene polyoxypropylene glycol, decaglyceryl laurate, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, etc. It is.

  These other surfactants as optional components can be blended alone or in combination of two or more, and the blending amount is usually 0.1 to 5% with respect to the total amount of the composition, and coconut oil fatty acid amide A range in which the total amount of propylbetaine and the other surfactants described above is 0.2 to 6% of the entire composition is preferable.

  Sweeteners include sodium saccharin, xylitol, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin. Preservatives include parabens such as butylparaben and ethylparaben, paraoxybenzoic acid Nonionic antibacterial agents such as esters, sodium benzoate, and triclosan, cationic antibacterial agents such as benzethonium chloride, benzalkonium chloride, and cetylpyridinium chloride, and essential oil components can be blended.

  As various active ingredients, in addition to the essential ingredient (A) dextranase, other active ingredients can be added. For example, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, tranexamic acid, Epsilon-aminocaproic acid, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, sodium chloride, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, triclosan, isopropylmethylphenol, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycero Chelating phosphate compounds such as phosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid And derivatives thereof, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, benzethonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, sweet cherry extract, buckwheat extract, chamomile, Extracts such as clove, rosemary, ougon, safflower and the like can be mentioned. In addition, the addition amount of these active ingredients can be made into an effective amount in the range which does not prevent the effect of this invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Natural roses such as absolute rose and orange flower, and fragrances processed with these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powder fragrance, etc.), menthol, carvone , Anethole, cineol, methyl salicylate, syn Mic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral , Pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, Isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, and dentifrice composition The well-known perfume material used for can be used, and it is not limited to the perfume of an Example.

  The blending amount of the fragrance is not particularly limited, however, the above fragrance material is preferably used in a composition of 0.000001 to 1%. Moreover, as a fragrance | flavor for fragrance | flavor using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 No. is exemplified.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%. The blending amounts of coconut oil fatty acid amidopropyl betaine and lauric acid amidopropyl betaine in the table indicate blending amounts in terms of pure content.

Examples and comparative examples
The toothpaste compositions having the compositions shown in Tables 1 and 2 were prepared by the following method, and the innermost layer was a linear low-density polyethylene laminate tube having a diameter of 26 mm (LDPE55 / PET12 / LDPE20 / white LDPE60 / EMAA20 / AL10 / 50 g of EMAA30 / LDPE20 / LLDPE30 and a thickness of 257 μm (Dai Nippon Printing Co., Ltd.) was filled. The dextranase stabilizing effect, foaming, tastelessness, and refreshing feeling after use were evaluated by the following methods. The results are shown in Tables 1 and 2.

(1) Preparation of test dentifrice composition Preparation of a dentifrice composition was performed by dissolving a water-soluble substance such as sodium chondroitin sulfate, sodium saccharin, and sorbit in purified water, and then dispersing a binder such as sodium alginate. A propylene glycol solution was added, and coconut oil fatty acid amidopropyl betaine and polyoxyethylene (20) hydrogenated castor oil were added and stirred. Then, the fragrance | flavor, the abrasive | polishing agent, the dextranase, and the sodium lauryl sulfate were added in order, and also it stirred under pressure reduction (40 mmHg), and obtained the dentifrice composition. In addition, the unimixer (FM-SR-25, POWEX CORPORATION) was used for manufacture.

  For the preparation of these dentifrice compositions, dextranase (13,000 U / g product, manufactured by Daiichi Sankyo Propharma Co., Ltd.), chondroitin sodium sulfate (manufactured by Wako Pure Chemical Industries, Ltd.), coconut oil fatty acid amide Propyl betaine (manufactured by Degussa, TEGO Betaine CK OK, 30% aqueous solution), lauric acid amidopropyl betaine (manufactured by Kao Corporation, Amphithol 20AB, 30% aqueous solution) were used. In addition, sodium fluoride, sodium saccharin, sodium lauryl sulfate, anhydrous silicic acid, xanthan gum, sodium alginate, sodium polyacrylate, propylene glycol, polyoxyethylene (20) hydrogenated castor oil, water use quasi-drug raw material standard products It was. As the sodium polyacrylate, Rheojic 250H (manufactured by Nippon Pure Chemicals Co., Ltd.) was used. About sorbit, the dentifrice composition was prepared using the 70% aqueous solution goods, and the compounding quantity of 70% aqueous solution was shown in the table | surface.

The abbreviations and names in the layer structure of the laminated tube used are as follows, and the numbers following the abbreviations indicate the thickness (μm) of each layer.
LDPE: Low density polyethylene white LDPE: White low density polyethylene LLDPE: Linear low density polyethylene AL: Aluminum EAA: Copolymer resin of ethylene / acrylic acid PET: Polyethylene terephthalate EMAA: Copolymer resin of ethylene / methacrylic acid SiOx -PET: Glass-deposited polyethylene terephthalate

(2) Evaluation of dextranase stabilization effect 50 g of the dentifrice composition was filled in the above laminate tube and stored at 40 ° C. for 1 month, and then 0.6 g of the dentifrice composition was added to 15 mL of 0.1 M phosphate buffer. The suspension was centrifuged as a test solution. 1 mL of this test solution was added to 2 mL of a 1% dextran solution, reacted in a constant temperature bath at 40 ° C. for exactly 10 minutes, and the amount of reducing sugar produced was measured using the Somogy Nelson method. One unit of dextranase was defined as the amount of dextranase that produces free reducing sugar corresponding to 1 μmol of glucose per minute, and the average value of the residual rate of dextranase three times was determined and evaluated according to the following criteria.

Score standard ◎: Residual rate 95% or more ○: Residual rate 85% or more and less than 95% △: Residual rate 75% or more and less than 85% ×: Residual rate <75%

(3) Evaluation of foaming Evaluated by a sensory test using 10 expert panelists, about 1 g of a dentifrice composition was placed on a commercial product toothbrush and used for a method of brushing normal teeth. The foaming of the dentifrice composition in the oral cavity during use was evaluated in the following four stages in comparison with the control product (Comparative Example 3). The average score of 10 people was calculated and judged according to the following criteria.

Good foaming (control product: Comparative Example 3)
4: The amount of foaming is very large and the feeling of use is excellent 3: The amount of foaming is quite large and the feeling of use is satisfactory 2: The amount of foaming is slightly large and the feeling of use is slightly good 1: The amount of foaming is the same or less, The feeling of use is bad
Criteria for foaming ◎: 3.0 to 4.0 points ○: 2.0 to less than 3.0 points △: 1.5 to less than 2.0 points ×: Less than 1.5 points

(4) Evaluation of tastelessness It evaluated by the sensory test using ten expert panelists. About 1 g of the dentifrice composition was placed on a commercial product toothbrush, brushed for 3 minutes, and the taste felt after use was evaluated in the following four stages in comparison with the control product (Comparative Example 2). The average score of 10 people was calculated and judged according to the following criteria.

No taste (control product: Comparative Example 2)
4: No nasty taste 3: Little nasty taste and no problem 2: Has an odd taste equivalent to the control product 1: Has an odd taste
Criteria for lack of taste ◎: 3.5 to 4.0 points ○: 3.0 to less than 3.5 points △: 2.0 to less than 3.0 points ×: Less than 2.0 points

(5) Evaluation of refreshing feeling after use It evaluated by the sensory test using 10 expert panelists. About 1 g of the dentifrice composition was placed on a commercially available toothbrush, brushed for 3 minutes, and a refreshing feeling in the oral cavity felt after use (the formulation was not sticky in the oral cavity and could be rinsed quickly, and the user was refreshed. The following four levels were evaluated in comparison with the control product (Comparative Example 2). The average score of 10 people was calculated and judged according to the following criteria.

Refreshing feeling after use (control product: Comparative Example 2)
4: The feeling of refreshing is very high 3: The feeling of refreshing is quite high 2: The feeling of refreshing is slightly high 1: The same feeling as the control product or inferior to the target product
Judgment criteria for refreshing feeling ◎: 3.0 to 4.0 points ○: 2.0 to less than 3.0 points △: 1.5 to less than 2.0 points ×: Less than 1.5 points

  From the results shown in Tables 1 and 2, the dentifrice composition of the present invention has a high aging storage stabilizing effect of dextranase, excellent foaming, almost no off-taste, and a refreshing sensation in the oral cavity can be obtained satisfactorily. It was confirmed.

Claims (2)

  (A) dextranase, (B) sodium chondroitin sulfate, and (C) coconut oil fatty acid amidopropyl betaine, (B) the amount of sodium chondroitin sulfate is 0.1 to 3.0% by mass, (C ) Dentifrice composition, wherein the blending amount of coconut oil fatty acid amidopropyl betaine is 0.1 to 1.0% by mass.   The dentifrice composition according to claim 1, wherein the mass ratio of component (C) / component (B) is 0.1 to 3.0.