CN102548526A

CN102548526A - Dentifrice composition

Info

Publication number: CN102548526A
Application number: CN2010800429286A
Authority: CN
Inventors: 中村晶; 天野步; 平山隆
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2009-11-06
Filing date: 2010-11-01
Publication date: 2012-07-04
Anticipated expiration: 2030-11-01
Also published as: KR20120086685A; HK1171941A1; CN102548526B; JP2011098920A; JP5597970B2; WO2011055709A1; KR101821422B1

Abstract

Disclosed is a dentifrice composition which exhibits excellent bactericidal effect on biofilms, while having excellent hyperesthesia suppressing activity. The dentifrice composition is free from unpleasant taste and provides excellent feeling of use. Specifically disclosed is a dentifrice composition which is characterized by containing (A) isopropyl methyl phenol, (B) one or more substances selected from among potassium nitrate, aluminum lactate and strontium chloride, (C) one or more fragrance material components selected from among 3-octanol, 3-octyl acetate, 3-octanone and fenchone, and (D) an anionic surfactant and/or a nonionic surfactant. The dentifrice composition additionally contains (E) anisaldehyde.

Description

Dentrifice composition

Technical field

The present invention relates to biological film sterilizing power and hyperesthesia abirritation excellence, do not have unpleasant taste, and the excellent Dentrifice composition of usability.

Background technology

The gingival atrophyes such as development of periodontal disease cause dentin to expose thereby the dentin acroesthesia is, stimulations such as friction, cold material are passed on the nerve via dentinal tubule, cause the disease of pain.Therefore; Very effective in order to prevent and suppress the dentin acroesthesia, use to have concurrently the oral biological film antibacterial of killing the periodontal disease cause of disease with the composition for oral cavity of the nerve anesthesia that has used hyperesthesia mitigation composition or two kinds of effects of mitigation pain that dentinal tubule's blockade effect brings.

The antibacterial of oral biological film is the method for the various antibacterials in the biomembrane in the antagonism oral cavity, and these antibacterials are considered to cause the reason of dental caries, periodontal disease two big oral diseases.The oral cavity bacterium relevant with oral disease can be given an example; The Streptococcus mutans relevant streptococcus such as (S.mutans) with dental caries; The porphyromonas gingivalis relevant with periodontitis (P.gingivalis) etc. are master's antibacterial with obligate anaerobic property gram negative bacteria bacillus; In addition, also have the nuclear Fusobacterium oral cavity bacteriums such as (F.nucleatums) relevant with the reason of halitosis.As effective prevention, improve the means of oral disease, keep that the low-level of pathogenic bacteria number in the biomembrane is considered to useful in the oral cavity.

In order to reduce pathogen bacterial population in the oral cavity; It is effective using slightly water-soluble antibacterial, cationic antibacterial, anionic antibacterial etc.; Particularly for the antibacterial in the biomembrane; Have document to propose, the high isopropyl methyl phenol of infiltration bactericidal effect can be brought into play the effect (patent documentation 1: Japanese Patent Laid is opened 2006-182662 communique, patent documentation 2: Japanese Patent Laid is opened 2006-124315 communique, patent documentation 3: Japanese Patent Laid is opened 2005-179266 communique, patent documentation 4: Japanese Patent Laid is opened the 2006-69909 communique) that suppresses oral biological film.

On the other hand; Preventive measure about the dentin acroesthesia; There is document to propose the known effective ingredient potassium nitrate that nerve anesthesia is arranged, block the prevention hyperesthesia effect of dentinal tubule's effect, aluctyl., strontium chloride etc. are blended in the oral cavity composition, relaxes the technology of pain.For example propose in the patent documentation 5 (No. 3863006 description of United States Patent (USP)); The dentifrice that use contains potassium salt such as potassium nitrate was brushed teeth after several weeks; The minimizing of hemodia property; In the patent documentation 6 (Japanese Patent Laid is opened clear 60-48926 communique), propose potassium nitrate is attached to gingiva and the structural method of disposal of periodontal membrane.Disclose in the patent documentation 7 (japanese patent laid-open 5-155745 communique) in addition and used the oral cavity composition that contains aluminum salt such as aluctyl. to suppress the dentin acroesthesia; In the patent documentation 8 (Japanese Patent Laid is opened the 2001-172146 communique) a kind of composition for oral cavity has been proposed; It contains the aluminum salt such as potassium nitrate and aluctyl. of certain concentration; The prevention of dentin acroesthesia and therapeutic effect are excellent, and use feeling is good.Patent documentation 9 (No. 3122483 description of United States Patent (USP)) proposes to contain the composition for oral cavity of strontium chloride.

It has been generally acknowledged that, in Dentrifice composition, mix slightly water-soluble sterilization component and hyperesthesia mitigation compositions such as isopropyl methyl phenol, can have biomembranous bactericidal effect of periodontal and dentin hyperesthesia abirritation concurrently.But; Isopropyl methyl phenol and potassium nitrate, aluctyl., the such hyperesthesia of strontium chloride are relaxed composition and usefulness; Can produce distinctive unpleasant taste; The compositions that contains these two kinds of compositions is because said unpleasant taste produces usability by the shortcoming of significantly damaging, and expectation can improve this point.

Problem to the unpleasant taste that comes from isopropyl methyl phenol; Known have: for example; Through with specific acyl sarcosinates with respect to phenyl phenol with specific mixed proportion combined hybrid, reduce the abnormal flavour of antimicrobial component technology (patent documentation 10: Japanese Patent Laid is opened the 2007-161613 communique) thereby, through 1-menthol and sodium chloride are blended in the technology (patent documentation 11: Japanese Patent Laid is opened the 2008-143825 communique) that reduces foreign odor and abnormal flavour in the isopropyl methyl phenol with specific mass ratio.But during the macro-mixing acyl sarcosinates, can produce the oral mucosa of thinking to come from acyl sarcosinates stimulates, and in addition, during mixed chlorinated sodium, thereby produces because saline taste makes new problems such as the type of fragrance is restricted sometimes.

In addition; Problem to the unpleasant taste that comes from potassium nitrate; Following these technology have been proposed: with specific ratio mixing water dissolubility polyphosphoric acids in potassium nitrate; And polyols blend, thereby improve the sense of discomfort of bitterness, astringent taste, convergence and throat technology (patent documentation 12: Japanese Patent Laid is opened the 2006-96696 communique) thereby, mix the technology (patent documentation 13: Japanese Patent Laid is opened the 2002-302450 communique) that specific organic compound, plant extract and sodium bicarbonate are covered bitterness.But, during mixing water dissolubility polyphosphoric acids, produce the unpleasant taste that comes from the water solublity polyphosphoric acids sometimes, when mixed plant extract or sodium bicarbonate, can produce the new problems such as unpleasant taste that come from the two.

To the problem of the unpleasant taste that comes from aluctyl., thereby proposed through in the preparation of non-water system, adding the technology (patent documentation 14: Japanese Patent Laid is opened the 2002-302429 communique) that sodium bicarbonate reduces bitterness, astringent taste.But the hyperesthesia that the preparation of so non-water system can not fully obtain potassium nitrate suppresses effect.

Cover the method that reduces unpleasant taste thereby also have through sweeting agents such as glucide, still, in this case, so necessarily can suppress unpleasant taste hardly because the taste of sweeting agent is crossed by force.

Patent documentation 8 is to improve potassium nitrate and the technology that comes from the astringent taste of aluctyl. of coming from, and this technology reduces the distinctive unpleasant taste that comes from isopropyl methyl phenol and hyperesthesia inhibition composition unsatisfactorily.

In addition, come from unpleasant taste and the potpourri that isopropyl methyl phenol or hyperesthesia suppress composition, because the unpleasant taste that spice itself has, in use can feel unpleasant taste sometimes in order to cover.

Technology as mixing isopropyl methyl phenol and fragrance component for example has patent documentation 11.Have anethole and the blended technology of eucalyptole, vanillin, citronellal and cinnamic aldehyde (patent documentation 15: Japanese Patent Laid is opened the 2003-73282 communique) as the technology of improving the bitterness of potassium nitrate through fragrance component.In addition, it is on the books in the embodiment 11～17,20,21,23 of the embodiment 17 of the embodiment 1～3,6～12,15～20 of the embodiment 1～13 of patent documentation 1, patent documentation 4, patent documentation 16 (No. 2007/69447 pamphlet of International Publication), patent documentation 17 (spy opens the 2005-179266 communique) to have mixed the composition of isopropyl methyl phenol and anisaldehyde.

But these technology all can not be improved the unpleasant taste that comes from isopropyl methyl phenol and hyperesthesia inhibition uniqueness composition, in use fully.

Therefore, seek to obtain not only biological film sterilizing power and hyperesthesia abirritation excellence, and come from the new technique of the Dentrifice composition that unpleasant taste is effectively reduced, usability is excellent of blending constituent.

The prior art document

Patent documentation

Patent documentation 1: Japanese Patent Laid is opened the 2006-182662 communique

Patent documentation 2: Japanese Patent Laid is opened the 2006-124315 communique

Patent documentation 3: Japanese Patent Laid is opened the 2005-179266 communique

Patent documentation 4: Japanese Patent Laid is opened the 2006-69909 communique

Patent documentation 5: No. 3863006 description of United States Patent (USP)

Patent documentation 6: Japanese Patent Laid is opened clear 60-48926 communique

Patent documentation 7: japanese patent laid-open 5-155745 communique

Patent documentation 8: Japanese Patent Laid is opened the 2001-172146 communique

Patent documentation 9: No. 3122483 description of United States Patent (USP)

Patent documentation 10: Japanese Patent Laid is opened the 2007-161613 communique

Patent documentation 11: Japanese Patent Laid is opened the 2008-143825 communique

Patent documentation 12: Japanese Patent Laid is opened the 2006-96696 communique

Patent documentation 13: Japanese Patent Laid is opened the 2002-302450 communique

Patent documentation 14: Japanese Patent Laid is opened the 2002-302429 communique

Patent documentation 15: Japanese Patent Laid is opened the 2003-73282 communique

Patent documentation 16: No. 2007/69447 pamphlet of International Publication

Patent documentation 17: Japanese Patent Laid is opened the 2005-179266 communique

Summary of the invention

The present invention In view of the foregoing forms, and purpose is to provide a kind of biological film sterilizing power and hyperesthesia abirritation excellence, does not have unpleasant taste, and the excellent Dentrifice composition of usability.

The invention people is for reaching the conscientiously research repeatedly of said purpose, and the result finds, through mixing (A) isopropyl methyl phenol,

(B) be selected from potassium nitrate, aluctyl., the strontium chloride more than a kind or 2 kinds, (C) be selected from the fragrance component more than a kind or 2 kinds, (D) anion surfactant and/or non-ionic surface active agent in 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone; All of a sudden can obtain biological film sterilizing power and hyperesthesia abirritation excellence, not have unpleasant taste and the excellent Dentrifice composition of usability, and accomplish the present invention.

Promptly; The present invention is through also suppressing composition with isopropyl methyl phenol and specific hyperesthesia and it being mixed in the Dentrifice composition that contains anion surfactant and/or non-ionic surface active agent; Can bring into play excellent biological film sterilizing power and hyperesthesia abirritation; And then; Through also using and mixing the specific fragrance component except these compositions, can also when obtaining said effect, cover effectively owing to also suppressing the unpleasant taste that composition produces with isopropyl methyl phenol and hyperesthesia, be the Dentrifice composition that does not have the usability that has excellence concurrently of unpleasant taste.

The fragrance component of said (C) composition all has unique fragrance, and trace uses in cheese flavor spice etc. is in harmonious proportion spice sometimes, but because himself offending fragrance, therefore the use as Dentrifice composition spice is restricted.The inventor suppresses composition and usefulness with the specific spice of such (C) composition with isopropyl methyl phenol and specific hyperesthesia; Be surprised to find that; Can effectively suppress to come from isopropyl methyl phenol and specific hyperesthesia is suppressed to the peculiar unpleasant taste of branch; The distinctive unpleasant taste that promptly produces with the astringent taste that comes from hyperesthesia inhibition composition by the bitterness that comes from isopropyl methyl phenol; And, the imperceptible unpleasant taste that comes from potpourri, the spice that can obtain in Dentrifice composition, generally to use at present unapproachable good usability.

Among the present invention, (B) composition/(A) mass ratio of composition is 2～700, thus, can improve the inhibition effect of biological film sterilizing power, unpleasant taste better.

And then, among the present invention,, can reduce unpleasant taste better through in the Dentrifice composition that has mixed said (A)～(D) composition, mixing (E) anisaldehyde, can further improve usability.

Therefore, the present invention provides following Dentrifice composition.

(1) a kind of Dentrifice composition is characterized in that, contains

(A) isopropyl methyl phenol,

(B) be selected from potassium nitrate, aluctyl., the strontium chloride more than a kind or 2 kinds,

(C) be selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone the fragrance component more than a kind or 2 kinds and

(D) anion surfactant and/or non-ionic surface active agent

Form.

(2) like the Dentrifice composition of (1) record, it is characterized in that (B) composition/(A) mass ratio of composition is 2～700.

(3) like the Dentrifice composition of (1) or (2) record, it is characterized in that (D) composition is alkyl sulfate and polyoxyethylene hardened castor oil and/or polyoxyethylene alkyl ether.

(4) like the Dentrifice composition of (1), (2) or (3) record, it is characterized in that, contain (A) composition 0.01～0.2 quality %, (B) composition 0.1～15 quality %, (C) composition 0.0001～0.1 quality %, (D) composition 0.1～5 quality %.

(5) like the Dentrifice composition of any 1 record of (1)～(4), it is characterized in that, also contain (E) anisaldehyde.

(6) like the Dentrifice composition of (5) record, it is characterized in that, contain (E) composition 0.0001～0.1 quality %.

(7) a kind of toothpaste further mixes thickening agent 10～70 quality %, binding agent 0.1～5 quality %, 0～50 quality % is formulated for grinding agent in the Dentrifice composition of any 1 record of (1)～(6).

The invention effect

Dentrifice composition of the present invention, biological film sterilizing power and hyperesthesia abirritation are excellent, do not have unpleasant taste, and usability is excellent, and be therefore effective for the prevention or the treatment of dentin acroesthesia.

The specific embodiment

Below, the present invention will be described in more detail.The characteristic of Dentrifice composition of the present invention is, contain (A) isopropyl methyl phenol, (B) be selected from potassium nitrate, aluctyl., the strontium chloride more than a kind or 2 kinds, (C) be selected from the fragrance component more than a kind or 2 kinds, (D) anion surfactant and/or non-ionic surface active agent in 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone.

(A) isopropyl methyl phenol that uses among the present invention is 4-isopropyl-3-methylphenol, can use Osaka to change into the commercially available article such as commodity that (strain) sells.

(A) combined amount of isopropyl methyl phenol is preferably 0.01～0.2% all (quality %, down together) of compositions, is more preferably 0.02～0.1%.Less than 0.01% can not be brought into play sufficient bactericidal effect sometimes, surpasses 0.2%, comes from the unpleasant taste grow of isopropyl methyl phenol, and taste is variation sometimes.

(B) potassium nitrate of composition, aluctyl. and strontium chloride are blended as being used for preventing or treating the effective ingredient of dentin acroesthesia, wherein, from hyperesthesia inhibitory action this point, preferably use potassium nitrate and aluctyl..These (B) compositions can use commercially available article; For example; The potassium nitrate potassium nitrate that (strain) マ Star モト hands over the merchant to sell of can giving an example, the aluctyl. aluctyl. that the wild chemistry of Musashi (strain) is sold of can giving an example, strontium chloride salt can give an example strontium chloride six water that pure chemistry (strain) sells and thing etc.

Said (B) composition can mix a kind separately, but it is desirable to and with 2 kinds or 3 kinds.For example, preferred compositions is used potassium nitrate and aluctyl., potassium nitrate and strontium chloride, wherein it is desirable to and with potassium nitrate and aluctyl..

(B) combined amount of composition it is desirable to compositions all 0.1～15%, especially it is desirable to 0.3～10%, it is desirable to 0.5～10% especially.Less than 0.1% can not be brought into play the hyperesthesia abirritation sometimes, surpasses 15%, and unpleasant taste is strong excessively, becomes sometimes to use.

Said hyperesthesia suppresses the combined amount separately of composition; Adjustment can suit in the combined amount scope of said (B) composition; The combined amount of potassium nitrate it is desirable to compositions all 0.1～15%, it is desirable to 1～10% especially, the words of less than 0.1%; Sometimes can not bring into play the hyperesthesia abirritation; Even, occur such situation sometimes, thereby make its influence that reaches the inorganic salt of emulsifying, dispersity unpleasant taste grow that diminishes for what the oil phase that makes slightly water-soluble compositions such as containing isopropyl methyl phenol and fragrance component etc. used with stable mixing of water.Surpass 15%, unpleasant taste is strong excessively, should not use sometimes.

The combined amount of aluctyl. or strontium chloride it is desirable to account for respectively compositions all 0.1～10%, especially it is desirable to 0.5～5%.The words of less than 0.1%; Sometimes can not bring into play the hyperesthesia abirritation; Even; Occur such situation sometimes, thereby make its influence that reaches the inorganic salt of emulsifying, dispersity unpleasant taste grow that diminishes for what the oil phase that makes slightly water-soluble compositions such as containing isopropyl methyl phenol and fragrance component etc. used with stable mixing of water.Surpass 10%, unpleasant taste is strong excessively, should not use sometimes.

Among the present invention, (B) composition/(A) blending ratio of composition it is desirable to 1～1000 by quality ratio, it is desirable to 2～700 especially.(B)/(A) less than 1, and the unpleasant taste sensation that comes from isopropyl methyl phenol sometimes is strong, surpasses 1000, can not obtain satisfied biological film sterilizing power sometimes, and the unpleasant taste sensation that comes from (B) composition is strong, and usability is poor.

(C) composition is to be used for covering coming from isopropyl methyl phenol and (B) effective fragrance component of the unpleasant taste of the uniqueness of composition, is the fragrance component more than a kind or 2 kinds that is selected from 3-capryl alcohol, 3-octyl acetate, 3-octanone, the fenchone.

When making up 2 kinds of the above fragrance components, suitable is the combination of 3-capryl alcohol and 3-octyl acetate and/or fenchone.

Even capryl alcohol generally can not reach as the 1-capryl alcohol of the spice of Dentrifice composition and cover satisfactorily from the isopropyl methyl phenol and (B) target of the unhappy abnormal smells from the patient of composition, and is therefore suitable to fragrance component of the present invention.

Said (C) composition can use commercially available article, and for example the 3-capryl alcohol can use the product of the wild spice of salt (strain), 3-octyl acetate and 3-octanone can use respectively (strain) aboveground spice manufacturing product, fenchone can use the product of fragrant Rong Xingye (strain) etc.

(C) the not special restriction of total combined amount of composition with respect to total composition, it is desirable to 0.0001～0.1%, it is desirable to 0.0005～0.05% especially, especially it is desirable to 0.001～0.02%.Combined amount less than 0.0001% can not be covered the unpleasant taste of the uniqueness that isopropyl methyl phenol and (B) composition have sometimes, and usability is poor, surpasses 0.1%, and the fragrance of fragrance component itself is strong excessively sometimes, the generation unpleasant taste.

(D) composition is anion surfactant and/or non-ionic surface active agent, can mix more than a kind or 2 kinds.Under such situation; Anion surfactant or non-ionic surface active agent can mix (a mixed anion surfactant or only mix non-ionic surface active agent) separately; Perhaps can and with anion surfactant and non-ionic surface active agent, still it is desirable to and with anion surfactant and non-ionic surface active agent.

Anion surfactant can give an example N-acyl glutamate, N-methyl-N acyl methyltaurin sodium, N-methyl-N-acyl group Sodium L-alaninate, the alpha-olefin sodium sulfonate etc. such as acyl sarcosinates, dodecylbenzene sodium sulfonate, hydrogenated coconut glycerine monofatty ester sulfate mono sodium, lauryl sulfoethanoic acid. sodium, N-palmityl sodium glutamate of alkyl sulfates such as sodium lauryl sulfate, sodium tetradecyl sulfate, sodium N-lauroyl sarcosinate, tetradecanoyl sodium sarcosinate etc.; Wherein, Alkyl sulfate; Especially alkylsurfuric acid sodium salt; From biological film sterilizing power, (A) and (C) the dissolving with dispersibility, suppress unpleasant taste this some of composition, comparatively suitable.

In the alkyl sulfate; The alkyl sulfate that concrete, sodium lauryl sulfate can use NIKKOL SLS (daylight ケミカ Le ズ (strain) system), have a mixed alkyl of lauryl and myristyl can use エマ one Le 10PT (flower king (strain) makes), TEXAPON OC-P commercially available article such as (Cognis Japan Ltd. systems).

Non-ionic surface active agent can use for example polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl polyglucoside, lauric acid ten polyglycerin ester etc.Wherein, from biological film sterilizing power, (A) and (C) the dissolving with dispersibility, suppress unpleasant taste this some of composition, it is desirable to polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether.

Do not have the unpleasant taste this point when using, it is desirable to that the average addition molal quantity of ethylene oxide is 10～30 moles in the polyoxyethylene hardened castor oil, especially it is desirable to 10～20 moles.10 moles of less thaies, the emulsifying of Dentrifice composition becomes insufficient, and the unpleasant taste in the time of can not fully suppressing to use sometimes surpasses on 30 moles the open market and does not sell.

Such polyoxyethylene hardened castor oil can use commercially available article.For example; NIKKOL HCO-10 (polyoxyethylene (10) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-20 (polyoxyethylene (20) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-30 (polyoxyethylene (30) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-40 (polyoxyethylene (40) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-60 (polyoxyethylene (60) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-80 (polyoxyethylene (80) hardened castor oil; Daylight ケミカ Le ズ (strain) system); NIKKOL HCO-100 (polyoxyethylene (100) hardened castor oil; Daylight ケミカ Le ズ (strain) system) etc.

From biological film sterilizing power, (A) and (C) the dissolving with dispersibility, suppress unpleasant taste this some of composition; It is desirable to; The average addition molal quantity of ethylene oxide is 3～40 moles in the polyoxyethylene alkyl ether; Especially it is desirable to 5～20 moles, the carbon number of alkyl it is desirable to 12～18, it is desirable to 16～18 especially.Particularly, can give an example Polyoxyethylene cetyl ether in said scope of the average addition molal quantity of ethylene oxide, polyoxyethylene octadecyl ether, polyoxyethylene lauryl ether etc.

Such polyoxyethylene alkyl ether can use commercially available article.For example; Polyoxyethylene cetyl ether can give an example EMALEX 103 (polyoxyethylene (3) cetyl ether, Japanese エマ Le ジヨ Application (strain) system), EMALEX105 (polyoxyethylene (5) cetyl ether, Japanese エマ Le ジヨ Application (strain) system), EMALEX107 (polyoxyethylene (7) cetyl ether, Japanese エマ Le ジヨ Application (strain) system) etc.; Polyoxyethylene octadecyl ether can give an example EMALEX603 (polyoxyethylene (3) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMALEX605 (polyoxyethylene (5) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMALEX606 (polyoxyethylene (6) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMALEX608 (polyoxyethylene (8) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX620 (polyoxyethylene (20) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX630 (polyoxyethylene (30) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX640 (polyoxyethylene (40) octadecyl ether, Japanese エマ Le ジヨ Application (strain) system) etc., polyoxyethylene lauryl ether can give an example EMAREX705 (polyoxyethylene (5) lauryl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX710 (polyoxyethylene (10) lauryl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX720 (polyoxyethylene (20) lauryl ether, Japanese エマ Le ジヨ Application (strain) system), EMAREX730 (polyoxyethylene (30) lauryl ether, Japanese エマ Le ジヨ Application (strain) system) etc.

Combination as anion surfactant and non-ionic surface active agent; Wherein, The also usefulness of suitable alkyl sulfate and polyoxyethylene hardened castor oil and/or polyoxyethylene alkyl ether, especially suitable is also using of alkyl sulfate and polyoxyethylene hardened castor oil.

(D) combined amount of anion surfactant and/or non-ionic surface active agent is suitable be compositions all 0.1～5%, especially suitable is 0.2～3%.Combined amount less than 0.1%, biological film sterilizing power descends sometimes, surpasses 5%, the unpleasant taste grow when using sometimes, usability is poor.

And then; It is desirable to mix anisaldehyde among the present invention as (E) composition; Come from the isopropyl methyl phenol and (B) effect of the distinctive unpleasant taste of composition, improved flavour through except the fragrance component of (C) composition, also adding anisaldehyde, can more effectively improve to cover.

Anisaldehyde can use the commercially available article such as product of ocean spice (strain).With respect to total composition, it is 0.0001～0.1% that its combined amount it is desirable to, and it is desirable to 0.0005～0.05% especially, especially it is desirable to 0.001～0.02%.The words of combined amount less than 0.0001%; Sometimes can not fully improve and come from the isopropyl methyl phenol and (B) the coverage effect of the unpleasant taste of composition, surpass 0.1%, the abnormal smells from the patient of anisaldehyde itself is strong excessively; Sometimes produce unpleasant taste, bring unplessantness displeasure to user.

When mixing (E) anisaldehyde; From improving the coverage effect come from the isopropyl methyl phenol and (B) unpleasant taste of composition better, improving fragrance this some better; Can make (C) composition and (E) the total combined amount of composition is 0.0002～0.15%, especially 0.002～0.03%.Add up to combined amount less than 0.0002%, can not fully improve the coverage effect of unpleasant taste sometimes, surpass 0.2%, (C) fragrance with (E) composition itself is strong excessively, produces unpleasant taste sometimes.

In addition,, especially it is desirable to the combination of 3-capryl alcohol and anisaldehyde, thus, can bring into play excellent especially coverage effect for the unpleasant taste of uniqueness as (C) composition and (E) combination of composition.

Dentrifice composition of the present invention can be mixed with toothpaste, liquid dentifrice etc. aptly, especially suits to be mixed with toothpaste, corresponding to its dosage form, except that said composition, can also mix other suitable known composition.Any can give an example for example thickening agent, binding agent, grinding agent of composition; And the spice that adds as required, surfactant, effective ingredient, pH regulator agent, antiseptic, sweeting agent, coloring agent etc., can in the scope of not damaging effect of the present invention, mix.Can these compositions be mixed according to usual way with water and make compositions of the present invention.

As thickening agent, can mix in the sugar alcohol, polyhydric alcohol of Sorbitol, glycerol, Polyethylene Glycol, propylene glycol, ethylene glycol, 1,3 butylene glycol, reduction starch saccharification thing etc. more than a kind or 2 kinds.The combined amount of said thickening agent, all with respect to compositions, it is desirable to 10～70% for toothpaste, it is desirable to 20～90% for liquid dentifrice.

Binding agent can give an example cellulose-based binding agent, xanthan gum, carrageenan, guar gum, sodium alginate, Poise C-80M, montorillonite clay, gelatin, sodium polyacrylate etc. such as sodium carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, hydroxymethyl ethyl cellulose, methylcellulose can mix these binding agents more than a kind or 2 kinds.Usually, combined amount is 0.1～5% with respect to total composition.

Except (C) composition and (E) the composition; Can also make up the spice that uses other; For example, natural perfume materials such as Eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, basil oil, Cardamom oil, Fructus Coriandri oil, Fructus Piperis peppermint oil, Oleum Menthae Rotundifoliae, Herba Menthae (Ha Star カ) oil, orange oil, Fructus Citri Limoniae oil, citrus seed oil, lime oil, oil of grapefruit, grape-fruit seed oil, platinum Fructus Citri grandis oil, Oleum lavandula angustifolia, oil of rosemary, bay oil, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, Celery oil, bay tree leaf oil, Herba Origani oil, pinke needle oil, orange blossom oil, lemongrass oil, attar of roses, Jasmin oil, patchouli oil, flag flower extractum, rose absolute, orange flower absolute, Rhizoma et radix valerianae absolute oil, Fructus Mangifera Indicae absolute oil, Herba Pogostemonis absolute oil, gingerin, Fructus Piperis resinon, green pepper (Capsicum) resinon, Fructus Capsici extract; And the spice of these spice processed being crossed (heat up in a steamer portion before going, go then heat up in a steamer portion, fractional distillation, liquid-liquid extraction, purification, powder perfumeization); And limonene, sobrerone, butanols, isoamyl alcohol, n-hexylene alcohol, cis-3-hexenol, cis-6-nonenol, linalool, alpha-terpineol, menthol, benzyl alcohol, phenethanol, anethole, thymol, estragole (Methyl chavicol), eugenol, carvone, menthone, pulegone, 1; The γ of 8-eucalyptol, ionone, watermelon ketone, n-hexyl aldehyde, trans-the 2-hexenoic aldehyde, citral, cinnamic aldehyde, benzaldehyde, ethyl acetate, ethyl n-butyrate., isoamyl acetate, Exceed 600, ethyl 2-methylbutyrate, allyl bexanoate, cyclohexane extraction allyl propionate, linalyl acetate, menthyl acetate, menthyl lactate, carvacryl acetate, phenoxyethyl isobutanoate, (-)-methyl cis-2-pent-2'-enyl-3-oxocyclopentylacetate, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl 2-aminobenzoate, phenylethyl glycidic ester, ethyl lactate, vanilione, maltol, carbon number 4～12 and δ lactone, ambrettolide, dimethylsulphide, trimethylpyrazine, Beta-methyl ethyl thio, furanone, ethylcyclopentenolone, 3-methyl cyclopentane-1; 2-diketone (Cyclotene), 2-Methyl Butyric Acid, propanoic acid, p-met hoxycinnamic aldehyde, 3-1-menthoxypropane-1; Single article spice such as 2-glycol, menthone glycerol acetal, spilanthol, monomethyl succinate, linalool oxide, vanillyl butyl ether, isopulegol; And then; Can also make up the mediation spice that uses strawberry essence, apple essence, melon essence, flavoring banana essence, flavoring peach essence, rasp berry essence, flavoring pineapple essence, grape essence, tropical fruit (tree) essence, Fructus Mangifera Indicae essence, prunus mume (sieb.) sieb.et zucc. essence, orange essence, Fructus Citri Limoniae essence, grapefruit essence, tea essence, butter essence, milk flavour etc., and the known perfume base that in Dentrifice composition, uses such as the perfume solvent of ethanol, propylene glycol, glyceryl triacetate, fatty acid glyceride etc.The combined amount of these perfume bases is not special to be limited, and it is desirable in compositions, use 0.000001～1%.In addition, use spice, preferably in compositions, use 0.1～2.0% as the tax of using above-mentioned perfume base is fragrant.

Surfactant can also mix amphoteric surfactant except the anion surfactant of (D) composition, non-ionic surface active agent.Amphoteric surfactant for example can use; Lauryl dimethyl aminoacetic acid betanin, N-fatty acid distribution of coconut oil acyl group-N-carboxyl methyl-N-hydroxyethyl imidazoles betanin, fatty acid distribution of coconut oil amido propyl dimethylamino acetic acid betanin, fatty acid distribution of coconut oil amido propyl betaine etc., be not limited to above-mentioned these.When mixing amphoteric surfactant, its combined amount normally 0.1～5%.

As various effective ingredient; Except (A) isopropyl methyl phenol, (B) potassium nitrate, aluctyl., strontium chloride; Can also mix other effective ingredient, for example copper compounds such as chelating property phosphate cpd, copper gluconate, berberine, hydroxamic acid and derivants thereof such as water-soluble phosphorus acid compounds such as the potassium salt of enzymes such as fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannic fluoride, glucanase, change dextranase, phosphoric acid, sodium salt, tranexamic acid, EACA, allantoin chloro hydroxy Al, hinokitol, sodium N-lauroyl sarcosinate, ascorbic acid, acetic acid dl-tocopherol, beta-cholestanol, α-bisabolol, chlorhexidine salt, azulene, enoxolone, glycyrrhizic acid, sodium copper chlorophyllin, chlorophyll, glycerophosphate, sodium tripolyphosphate, zeolite, methoxy-ethylene-copolymer-maleic anhydride, polyvinyl pyrrolidone, epidihydrocholesterol, cetylpyridinium chloride, benzethonium chloride, beta-cholestanol, neko, zinc citrate, Radix Angelicae Sinensis pilular extract, Cortex Phellodendri extractum, Flos Matricariae chamomillae, Flos Caryophylli, Herba Rosmarini Officinalis, the extract etc. of Radix Scutellariae, Flos Carthami etc.These mixing active ingredients amounts in the scope that does not hinder effect of the present invention, can be used effective dose.

Grinding agent can use for example silica gel; Aluminosilicate; The silicon based abrasive of zircoaluminate etc.; Calcium monohydrogenphosphate 2 hydrates; Calcium monohydrogenphosphate does not have hydrate; Calcium phosphate; Tetracalcium phosphate; OCP; The series of calcium phosphate grinding agent of calcium pyrophosphate etc.; Aluminium hydroxide; Aluminium oxide; Titanium dioxide; Crystallinity silicic acid zirconium; Polymethyl methacrylate; Insoluble calcium metaphosphate; Precipitated calcium carbonate; Ground calcium carbonate; Magnesium carbonate; Magnesium phosphate; Zeolite; Zirconium orthosilicate.; Hydroxyapatite; Fluoro apatite; Calcium deficiency apatite; In the synthetic resin based abrasive etc. more than a kind or 2 kinds.Under the situation of toothpaste, combined amount is generally 0～50% with respect to total composition, and especially 5～40%, under the situation of aqueous dentifrice, combined amount is generally 0～30% with respect to total composition, and especially 2～15%.

In the scope of not damaging effect of the present invention; Can add p-phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, pyrophosphoric acid, phosphoglycerol and carbonic acid and their potassium salt, sodium salt and ammonium salt, ribonucleic acid and its esters with common amount, so hydroxide water acidify sodium etc. more than a kind or 2 kinds as the pH regulator agent.

Antiseptic can give an example benzoates such as p-Hydroxybenzoates such as butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, ethylparaben, methyl parahydroxybenzoate, sodium benzoate, potassium sorbate etc.

Sweeting agent can give an example saccharin sodium, aspartame, stevioside, Flos Chrysanthemi extract, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine etc.

Coloring agent can give an example blue No. 1, yellow No. 4 (FD&C, Yellow No.5 (19140), green No. 3, red No. 105 etc.

The combined amount of these compositions in the scope of not damaging effect of the present invention, can be used common amount.

As container, the not special restriction of the material of accepting container can be used dentifrice composition, the normally used container of aqueous Dentrifice composition.

Embodiment

Below, enumerate embodiment and comparative example the present invention is detailed, but the present invention is not limited by following examples.In the following example, the short of special record of % all is meant quality %.

(embodiment, comparative example)

According to the Dentrifice composition of forming shown in following manufacturing approach preparation table 1～3.

(manufacturing approach)

The preparation of Dentrifice composition is as follows, in pure water, dissolves water-soluble substanceses such as saccharin sodium, sodium monofluorophosphate, D-sorbitol solution, then, to wherein adding in addition binding agent is dispersed in the propylene glycol and the liquid that obtains stirs.Then, polyoxyethylene (5) the octadecyl ether of adding polyoxyethylene hardened castor oil, heating for dissolving, spice, grinding agent, alkyl sodium sulfate etc., under reduced pressure (pressure 4kPa) continues to stir, and obtains Dentrifice composition.Use even blender (ユニミキサ one) (FM-SR-25, POWEREX CORPORATION society) in the manufacturing.

In the preparation of these Dentrifice compositions; Use isopropyl methyl phenol (Osaka changes into (strain) system), potassium nitrate ((strain) マ Star モト hands over merchant's system), aluctyl (the wild chemistry of Musashi (strain) system), strontium chloride (pure chemistry (strain) system), 3-octanol (the wild spices of salt (strain) system), 3-octyl acetate and 3-octanone ((strain) aboveground spices is made made), fenchone (fragrant Rong Xingye (strain) system), anisaldehyde (ocean spices (strain) system), 1-octanol (high sand perfume industry (strain) system), NaLS (daylight ケミカ Le ズ (strain) system, NIKKOL SLS), polyoxyethylene (20) hardened castor oil (daylight ケミカ Le ズ (strain) system, NIKKOL HCO-20), polyoxyethylene (5) octadecyl ether (Japanese エマ Le ジヨ Application (strain) system, EMALEX605), silica (ロ one デイア solar corona (strain) is made, TIXOSIL 73), D-sorbite (eastern and change into that industry (strain) is made, D-D-sorbitol solution (70% aqueous solution)), sodium carboxymethylcellulose (ダイセ Le chemical industry (strain), CMC1250); In addition, sodium monofluorophosphate, propane diols, saccharin sodium, titanium dioxide, pure water use the material that is suitable in the quasi drug raw material specification (medicine part outer article raw material specification) 2006.

About Sorbitol, use 70% aqueous solution article preparation Dentrifice composition.About spice, use the flavor compositions A～I shown in the perfume composition making shown in the table 5, the mixture table 4.

The Dentrifice composition 50g that obtains is filled in the laminated tube (the white LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30 of LDPE55/PET12/LDPE20/, thick 257 μ m (Dai Nippon Printing's (strain) system)) of the diameter 26mm that innermost layer is made up of straight chain shape low density polyethylene (LDPE).

Abbreviation and title in the layer structure of the laminated tube that uses are as follows, the thickness of latter linked each layer of numeral of abridging (μ m).

LDPE: low density polyethylene (LDPE)

White LDPE: white low density polyethylene

LLDPE: straight chain shape low density polyethylene (LDPE)

AL: aluminum

PET: PETG

EMAA: the copolymer resin of ethylene methacrylic acid

Have or not degree evaluation according to following method to what biological film sterilizing power, the hyperesthesia of the Dentrifice composition that obtains suppressed effect, unpleasant taste.The result is recorded in table 1～3 in the lump.

(1) model biological film sterilizing Evaluation on effect method

Handle hydroxyapatite (HA) plate of diameter 7mm with the non-stimulated saliva of the people behind the membrane filtration of 0.45 μ m; Handled 4 hours; In having added the pancreas peptone soybean broth culture medium of chlorhematin and menadione; 5 strain mixed stockers of continuous culture 2 all Streptococcus mutans (Streptococcus mutans), actinomyces naeslundii (Actinomyces naeslundii), veillonella parvula (Veillonella parvula), Fusobacterium nucleatum (Fusobacterium nucleatum) and porphyromonas gingivalis (Porphyromonas gingivalis) form the model biomembrane on the HA plate.Cultivate 2 Zhou Houqi, 1 time on the 1st, in the dentifrice formulation shown in the following table, add 2 times of quality population saliva (50mmol/L KCl+1mmol/L KH ₂PO ₄+ 1mmol/L CaCl ₂+ 0.1mmol/L MgCl ₂(pH7.0)), the centrifuged supernatant after the dispersion impregnated in the model biomembrane wherein as test medicine liquid, and impregnation process 3 minutes was cultivated 3 again.Cultivate when finishing, take out the model biomembrane, after the dispersion, on agar plate, cultivate, obtain the viable count of each bacterial classification in the model biomembrane thus.Viable count is because of condition of culture more or less changes, and makes population saliva replace test medicine to do the time spent, is about 8.5log cfu (CFU/HA plate), is judged as biological film sterilizing power height during not enough 6.0log cfu/HA plate.

Model biological film sterilizing effect assessment benchmark

◎: not enough 5.0log cfu/HA plate

Zero: more than the 5.0log cfu/HA plate～not enough 6.0log cfu/HA plate

△: more than the 6.0log cfu/HA plate～not enough 7.0log cfu/HA plate

*: more than the 7.0log cfu/HA plate

(2) hyperesthesia suppresses effect

Make when cold water keeps in the mouth tooth feel use 4 weeks test Dentrifice compositions continuously to 10 freezing people's acroesthesia juries; Then; The test Dentrifice composition that is filled in the laminated tube is extruded 1cm to toothbrush; According to brushing teeth 2 minutes, estimate according to the metewand-1 shown in following with usual identical method.Estimate 10 people's average mark according to metewand-2.

Metewand-1

5 minutes: after brushing teeth, when cold water kept in the mouth, it is freezing that tooth is not felt fully

4 minutes: after brushing teeth, when cold water kept in the mouth, it is freezing that tooth is not felt

3 minutes: after brushing teeth, when cold water kept in the mouth, tooth was not almost felt freezing, no problem level

2 minutes: after brushing teeth, when cold water kept in the mouth, tooth feel was freezing

1 minute: after brushing teeth, when cold water kept in the mouth, it is freezing that tooth is obviously felt

Metewand-2

◎: 10 people's average mark is more than 4.0 minutes

Zero: 10 people's average mark more than 3.0 minutes, less than 4.0 minutes

△: 10 people's average mark more than 2.0 minutes, less than 3.0 minutes

*: 10 people's average mark less than 2.0 minutes

(3) have or not the evaluation of unpleasant taste

Use 10 people's jury of experts to carry out sensory test.The about 1g of Dentrifice composition is placed on the commercially available article toothbrush, brushed teeth 3 minutes, have or not in using according to following scoring evaluation and feel unpleasant taste.Obtain the meansigma methods of 10 people's evaluation result,, will guarantee that the Dentrifice composition that ◎ and zero estimates is judged to be the Dentrifice composition that does not have unpleasant taste according to following benchmark.

(scoring)

4 minutes: do not have unpleasant taste fully

3 minutes: almost do not have unpleasant taste

2 minutes: unpleasant taste is arranged slightly

1 minute: unpleasant taste is arranged

(metewand)

◎: more than 3.7 minutes～below 4.0 minutes

◎～more than zero: 3.3 minute～less than 3.7 minutes

More than zero: 3.0 minute～less than 3.3 minutes

△: more than 2.0 minutes～less than 3.0 minutes

*: less than 2.0 minutes

[table 1-1]

[table 1-2]

[table 1-3]

[table 2]

[table 3-2]

[table 3-3]

[table 3-4]

Result by table 1～3 can know; When lacking any in (A)～(D) composition, when perhaps the combined amount of these compositions is improper, biological film sterilizing power, hyperesthesia inhibitory action and have or not a certain in the unpleasant taste can variation; Relative with it; Dentrifice composition of the present invention (embodiment), biological film sterilizing power and hyperesthesia inhibitory action be excellent, do not have unpleasant taste and usability good, possesses these excellent characteristics simultaneously.In addition, among the embodiment 1～80, any one that changes flavor compositions A into flavor compositions B～I also obtains same result.

[table 4]

*: said spice does not contain 3-capryl alcohol, 3-octyl acetate, 3-octanone, fenchone, anisaldehyde in forming.

[table 5-1]

< essence 1 is formed >

[table 5-2]

< essence 2 is formed >

[table 5-3]

< essence 3 is formed >
		Wintergreen oil	1 mass parts
Olibanum oil	1
		Orange blossom oil	1
Indian oil of verbena	1
		Oleum Rosae Rugosae	1
Rose absolute	1
		The Fructus Mangifera Indicae absolute oil	1
Flag flower extractum	1
		Orange flower absolute	1
Ethanol	1
		Add up to	10 mass parts

[table 5-4]

< essence 4 is formed >
		Menthyl lactate	1 mass parts
3-1-menthoxypropane-1, the 2-glycol	1
		The menthone glycerin ether	1
Spilanthol	1
		Monomethyl succinate	1
The linalool oxide	1
		The vanillyl butyl ether	1
Isopulegol	1
		Fructus Capsici extract	1
Gingerin	1
		The Fructus Piperis resinon	1
The green pepper resinon	1
		Ethanol	1
Add up to	13 mass parts

[table 5-5]

< essence 5 is formed >
		Furanone	1 mass parts
Ethylcyclopentenolone	1
		3-methyl cyclopentane-1, the 2-diketone	1
2-Methyl Butyric Acid	1
		Propanoic acid	1
P-met hoxycinnamic aldehyde	1
		Ethanol	1
Add up to	7 mass parts

[table 5-6]

< essence 6 is formed >

Claims

1. a Dentrifice composition is characterized in that, contains

(A) isopropyl methyl phenol,

(D) anion surfactant and/or non-ionic surface active agent

Form.

2. like the Dentrifice composition of claim 1 record, it is characterized in that (B) composition/(A) mass ratio of composition is 2～700.

3. like the Dentrifice composition of claim 1 or 2 records, it is characterized in that (D) composition is alkyl sulfate and polyoxyethylene hardened castor oil and/or polyoxyethylene alkyl ether.

4. like the Dentrifice composition of claim 1,2 or 3 records, it is characterized in that, contain (A) composition 0.01～0.2 quality %, (B) composition 0.1～15 quality %, (C) composition 0.0001～0.1 quality %, (D) composition 0.1～5 quality %.

5. like the Dentrifice composition of any 1 record of claim 1～4, it is characterized in that, also contain (E) anisaldehyde.

6. like the Dentrifice composition of claim 5 record, it is characterized in that, contain (E) composition 0.0001～0.1 quality %.

7. toothpaste further mixes thickening agent 10～70 quality %, binding agent 0.1～5 quality %, 0～50 quality % is formulated for grinding agent in the Dentrifice composition of any 1 record of claim 1～6.