JP5493731B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition excellent in biosterilizing power in the oral cavity and excellent in feeling of use (good foaming, unpleasant taste, and no irritation).

  The cause of oral diseases represented by caries and periodontal disease is bacteria that live in the oral cavity. Caries are infections caused by oral streptococci represented by Streptococcus mutans, and periodontal diseases are infections caused by bacteria mainly composed of anaerobic gram-negative bacilli such as Porphyromonas gingivalis. . Therefore, it is considered useful to sterilize or bacteriologically pathogenic bacteria in the oral cavity as an effective means for preventing and improving these oral diseases.

  On the other hand, these pathogenic bacteria form a biofilm in the oral cavity, and the bacteria in the biofilm are significantly less sensitive to drugs compared to planktonic bacteria that do not form a biofilm. Therefore, it has been considered that drugs that were effective against planktonic bacteria are not necessarily effective against bacteria in biofilms.

  In order to reduce the number of pathogenic bacteria in the oral cavity against such bacteria in a biofilm, it is effective to use a slightly water-soluble bactericidal agent, a cationic bactericidal agent, or an anionic bactericidal agent. Among these bacteria, isopropylmethylphenol having a high osmotic sterilization effect is preferably used (Patent Documents 1 and 2).

  However, the composition containing isopropylmethylphenol has a disadvantage that the feeling of use is remarkably impaired because it has a peculiar taste, and improvement of this point has been demanded.

  For such a problem, for example, a technique for reducing the taste of antibacterial components by combining a specific acyl sarcosine salt in combination with phenoxyethanol at a specific mixing ratio (Patent Document 3), l-menthol and sodium chloride in isopropyl The technique (patent document 4) which reduces a strange odor and taste by mix | blending with a specific mass ratio with respect to methylphenol is proposed. However, when a large amount of acyl sarcosine salt is added, oral mucosal irritation, which is considered to be derived from the acyl sarcosine salt, occurs, and when sodium chloride is added, the flavor type may be limited depending on the salty taste. It was difficult to say that it was a satisfactory experience.

  In addition, there is a method of reducing the taste by masking with a sweetener such as saccharin. However, in this case, the taste of the sweetener is emphasized too much and it cannot always be said that the taste can be suppressed. For this reason, in addition to being excellent in the biofilm sterilization effect derived from isopropylmethylphenol, a new technology that can satisfactorily reduce the taste symptom derived from isopropylmethylphenol has been demanded.

  By the way, when suffering from periodontal disease, a strong inflammatory reaction often occurs in the gums, and the gums may be sensitive to physical and chemical stimuli, and you feel subjective symptoms such as pain and bleeding when brushing your teeth. There are many things. For this reason, it is necessary to brush the tooth over a certain amount of time in order to effectively exert the bactericidal effect of isopropylmethylphenol in the oral cavity. In this case, the preventive effect of periodontal disease is improved without causing an inflammatory reaction. Therefore, there has been a need for a dentifrice composition that is either non-irritating or very low.

  In addition, the dentifrice composition is also required to have a cleaning feeling, and one of the textures that provides a satisfactory cleaning feeling is the foaminess when brushing teeth. However, in order to improve foaming at the time of brushing, generally the amount of sodium lauryl sulfate is often increased. In this case, there is a concern that irritation in the oral cavity becomes strong, and there is room for improvement. was there.

  Therefore, a dentifrice composition containing isopropylmethylphenol is required to have excellent biofilm sterilizing power in the oral cavity and excellent usability (good foaming, unpleasant taste, and no irritation). However, in the prior art, it was difficult to combine these characteristics.

  Patent Document 5 proposes a caries preventive coating composition containing a fragrance component (one or more selected from menthone, carvone, and ethyl butyrate), a bactericide, and a surfactant. In Example 23, a composition containing isopropylmethylphenol is described. However, this composition does not have sufficient effect of reducing the odor derived from isopropylmethylphenol and lack of irritation when brushing teeth.

JP 2005-179266 A JP 2006-182661 A JP 2007-161613 A JP 2008-143825 A JP 2005-187333 A

  The present invention has been made in view of the above circumstances, and is a dentifrice composition that is excellent in biofilm sterilization power in the oral cavity and excellent in feeling when brushing teeth (good foaming, unpleasant taste, and no irritation). The purpose is to provide.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) isopropylmethylphenol and (B) at least one fragrance selected from 3-octanol, 3-octyl acetate, and 3-octanone. A dentifrice composition having surprisingly superior oral biofilm sterilizing power and feeling of use (good foaming, tastelessness, and no irritation) by blending an ingredient and (C) acyl taurine salt Has been found to yield the present invention.

That is, as a result of investigations by the present inventors, oral biofilm bactericidal power can be obtained by adding isopropylmethylphenol to the dentifrice composition, but in this case, the user feels unpleasant and irritating at the time of brushing. The feeling of use was not satisfactory, and it was difficult to combine excellent oral biofilm sterilizing power and good feeling of use. According to the present invention, the dentifrice composition containing isopropylmethylphenol is blended with at least one fragrance component selected from 3-octanol, 3-octyl acetate, and 3-octanone, and an acyl taurine salt. , Which can solve these problems, has excellent bactericidal ability of oral biofilm, has good foaming when brushing teeth, has almost no taste of isopropylmethylphenol, and has almost no irritation in the mouth. An excellent dentifrice composition can be obtained.

In addition, since the fragrance | flavor component of said (B) component has characteristic fragrance | flavor and is used for trace amounts of some compound flavors, such as cheese, since it is unpleasant fragrance itself, dentifrice composition The use of things as perfumes was limited. The present inventors have surprisingly found that when the specific fragrance of the above component (B) is used in combination with isopropylmethylphenol in a dentifrice composition, the odor derived from isopropylmethylphenol can be sufficiently suppressed. .
Furthermore, in the present invention, an unpleasant masking effect can be further enhanced by adding (D) anisaldehyde to the dentifrice composition containing (A) to (C).

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
(A) 0.01-0.2% by mass of isopropylmethylphenol,
(B) 0.0004 to 0.1% by mass of at least one fragrance component selected from 3-octanol, 3-octyl acetate, and 3-octanone;
(C) A dentifrice composition comprising 0.1 to 5% by mass of an acyl taurine salt.
Claim 2 :
Furthermore, according to claim 1 dentifrice composition, wherein the containing (D) anisaldehyde.
Claim 3 :
(D) Dentifrice composition of Claim 2 containing 0.0001-0.1 mass% of component.

  The dentifrice composition containing isopropylmethylphenol of the present invention is excellent in oral biofilm bactericidal power and excellent in feeling when brushing teeth (good foaming, unpleasant taste, and no irritation). It is effective for prevention or improvement of oral diseases such as peri-disease.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is suitably prepared as a dentifrice such as a toothpaste, a liquid dentifrice, and a toothpaste, especially a toothpaste. (A) Isopropylmethylphenol, (B) 3-octanol, 3-octyl acetate And at least one fragrance component selected from 3-octanone and (C) an acyl taurine salt as an essential component.

  (A) Isopropylmethylphenol used in the present invention is 4-isopropyl-3-methylphenol, and commercially available products such as those manufactured by Osaka Kasei Co., Ltd. can be used.

The blending amount of (A) isopropylmethylphenol is preferably 0.01 to 0.2% (mass%, the same applies hereinafter), particularly 0.02 to 0.1% of the entire composition. If it is less than 0.01%, a sufficient bactericidal effect is not exhibited . If it exceeds 0.2%, an odor derived from isopropylmethylphenol is produced and the taste is deteriorated .

The component (B) is a fragrance component that is effective for masking the bad taste derived from isopropylmethylphenol and making it a good flavor. Among 3-octanol, 3-octyl acetate, 3-octanone, and Fencon , 3-octanol , 3-octyl acetate and 3-octanone are one or more fragrance ingredients.
When combining 2 or more types of the said fragrance | flavor components, the combination of 3-octanol, 3-octyl acetate, and / or Fencon is suitable.
Even if it is octanol, 1-octanol, which is general as a fragrance for a dentifrice composition, does not have an effect of masking the odor derived from isopropylmethylphenol, and is not suitable as a fragrance component according to the present invention.

The component (B) may be a commercial product, for example, 3-octanol product Shiono perfume Ltd., 3-octyl acetate, 3-octanone be used as each Ltd. Inoue perfume Mill Products Can do. Fencon can use products from Koei Kogyo Co., Ltd.

The total amount of component (B) is preferably 0.0004 to 0.1%, particularly 0.0005 to 0.05%, and particularly preferably 0.001 to 0.02%, based on the total amount of the composition. The amount is less than 0.0001% can not mask the disagreeable from isopropyl methylphenol, Ri poor usability exceeds 0.1%, produces a slap and flavor of perfume ingredients itself too strong.

  As the acylmethyl taurine salt of component (C), those having an acyl group having 8 to 18 carbon atoms, particularly 12 to 16 carbon atoms are preferred. Specifically, caprynoyl methyl taurine salt, lauroyl methyl taurine salt, cocoyl methyl taurine salt , Myristoyl methyl taurine salt, palmitoyl methyl taurine salt, stearoyl methyl taurine salt and the like. Among these, lauroyl methyl taurine salt and cocoyl methyl taurine salt are preferable, and lauroyl methyl taurine salt is particularly preferable. As the salt of acylmethyl taurine, alkali metal salts such as sodium salt and potassium salt are preferable, and sodium salt is particularly preferable.

  (C) The acyl taurine salt can use a commercial item, for example, N-cocoyl methyl taurine sodium aqueous solution (brand name: CMT-30, 30% aqueous solution), N-lauroyl methyl taurine sodium liquid of Nippon Emulsion Co., Ltd. (Trade name: LMT-30, 30% aqueous solution), N-myristoylmethyl taurine sodium (trade name: MMT) and the like can be used.

(C) The compounding quantity of acyl taurine salt is 0.1 to 5% of the whole composition, and 0.5 to 2% is especially preferable. When the amount is less than 0.1%, foaming is inferior . If it exceeds 5%, a bad taste occurs .

  Furthermore, in the present invention, it is preferable to blend (D) anisaldehyde, and by adding anisaldehyde in addition to the fragrance component of component (B), it is possible to further enhance the masking effect against the tasting taste derived from isopropylmethylphenol. And a better flavor can be obtained.

  As anisaldehyde, commercially available products such as products of Taiyo Perfume Co., Ltd. can be used. The blending amount is preferably 0.0001 to 0.1%, particularly 0.001 to 0.02%, based on the entire composition. If the blending amount is less than 0.0001%, the masking effect of the tastelessness may not be sufficiently enhanced. If the amount exceeds 0.1%, the flavor of the anisaldehyde itself is too strong as in the case of the component (B). May occur.

When (D) anisaldehyde is blended, the total blending amount of the component (B) and the component (D) is 0.0002 to 0.15%, particularly 0, in order to further enhance the masking effect of the taste that is derived from isopropylmethylphenol. It is desirable to be 0.002 to 0.03%. If the total blending amount is less than 0.0002%, the masking effect of disgusting may not be sufficiently increased, and if it exceeds 0.15%, the flavors of the components (B) and (D) themselves are too strong and disgusting. May occur.
As the combination of the component (B) and the component (D), a combination of 3-octanol and anisaldehyde is particularly preferable, and an especially excellent masking effect is exerted with respect to an odor derived from isopropylmethylphenol. The

  In the dentifrice composition of the present invention, in addition to the above-mentioned components, various other known components that are usually used in dentifrice compositions are blended as necessary within a range not impairing the effects of the present invention. Can do. Optional ingredients that can be blended include a binder, a surfactant, an abrasive, a wetting agent, a sweetener, a fragrance, a pH adjuster, an active ingredient or a medicinal ingredient, and an antiseptic.

  As binder, inorganic binder such as thickening silica, aluminum silicate, xanthan gum, sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, sodium alginate, tragacanth gum, karaya gum, arabiya gum, locust bean gum, Organic binders such as polyvinyl alcohol, sodium polyacrylate, cross-linked sodium polyacrylate, carboxyvinyl polymer, carbopol, and bee gum may be blended. The compounding amount of these binders is preferably 0.1 to 3% of the entire composition.

  As the surfactant, (C) an anionic surfactant other than the acyl taurine salt, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended, one kind alone or two or more kinds Can be combined.

Examples of the anionic surfactant include (C) acyl taurate, alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristol sarcosine, and dodecyl. Examples thereof include sodium benzenesulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, and N-acyl glutamate such as sodium N-palmitoyl glutamate.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.

  Nonionic surfactants include polyglycerin fatty acid esters, sucrose fatty acid esters, sucrose fatty acid esters such as maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactol fatty acid esters, alkylol amides, polyoxy Polyoxyethylene sorbitan fatty acid ester such as ethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether , Polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, pluronic and the like. Examples of amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

  In addition, when mix | blending the said surfactant, the compounding quantity is 0.1 to 5% of the whole composition, especially 0.3 to 5 as the total compounding quantity added with the compounding quantity of (C) acylmethyl taurine salt. % Is preferred.

Examples of abrasives include dicalcium phosphate dihydrate and anhydrous salts, calcium phosphate compounds such as primary calcium phosphate, tertiary calcium phosphate, and calcium pyrophosphate, silica-based abrasives such as precipitated silica and aluminosilicate, calcium carbonate, 1 type (s) or 2 or more types, such as calcium hydroxide, aluminum hydroxide, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, can be mix | blended.
The blending amount of the abrasive is usually 0 to 25%, particularly 2 to 20% of the whole composition.

  Examples of the wetting agent include glycerin, propylene glycol, polyhydric alcohols such as polyethylene glycol having an average molecular weight of 200 to 6,000, ethylene glycol, and 1,3-butylene glycol, and sugar alcohols such as sorbitol and reduced starch saccharified product. A seed | species can be mix | blended individually or in combination of 2 or more types. The blending amount is preferably 15 to 45% of the entire composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. The compounding quantity of a sweetener is 0.01 to 5% of the whole composition normally.
In addition, there is a method to reduce taste by masking sweet taste by blending sweeteners, but sweetener blends cannot suppress taste taste because the taste of sweetener is emphasized too much, and contain isopropylmethylphenol In such a dentifrice composition, it is not sufficient as a technique for suppressing the tasting taste derived from isopropylmethylphenol.

  In addition to the component (B), and the component (D), other fragrances include, for example, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, Peppermint oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, Celery oil, bay oil, origanum oil, pine needle oil, neroli oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchoulia absolute, ginger Natural fragrances such as leoresin, pepper oleoresin, capsicum oleoresin, capsicum extract, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume, limonene, pinene, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linalool, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol, anethole, thymol , Methylchavicol, eugenol, carvone, menthone, pulegone, 1,8-cineole, yonon, caron, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl butyrate , Isoamyl acetate, hexyl acetate, ethyl 2-methylbutyrate, allyl hexanoate, allyl cyclohexane propionate, linalyl acetate, menthyl acetate, menthyl lactate, carbyl acetate, phenoxyethyl isobutyrate, methyl jasmonate, Methyl salicylate, ethyl salicylate, methyl cinnamate, methyl anthranilate, phenyl ethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, ambretlide, dimethyl sulfide, trimethylpyrazine, ethyl β -Methylthiopropionate, furaneol, ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propionic acid, p-me Single fragrances such as xycinamic aldehyde, 3-l-menthoxypropane-1,2-diol, menthone glycerin acetal, spiranthol, monomenthyl succinate, linalool oxide, vanillyl butyl ether, isopulegol, strawberry flavor, apple flavor , Melon flavor, banana flavor, peach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor, ume flavor, orange flavor, lemon flavor, grapefruit flavor, tea flavor, butter flavor, milk flavor, etc. And ethyl alcohol, propylene glycol, triacetin, glycerin fatty acid ester Known perfume materials used in dentifrice compositions, such as perfume solvents such as stealth, can be used in combination. Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for perfume using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a composition.

  Examples of the pH adjuster include organic acids such as citric acid, lactic acid, malic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate. .

Medicinal or active ingredients include, in addition to isopropylmethylphenol, enzymes such as dextranase, amylase, protease, mutanase, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetic acid, chloride Anti-inflammatory agents such as sodium and vitamins, antibacterial agents such as copper chlorophyll, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, triclosan, hinokitiol and lysozyme chloride, calculus prevention such as pyrophosphates, polyphosphates and zeolites Amino acids such as glycine and proline can be added. In addition, the compounding quantity of a medicinal ingredient or an active ingredient can be made into an effective quantity in the range which does not interfere with the effect of this invention.
Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof.

  In addition, as an optional component, inorganic compounds such as calcium hydrogen phosphate, zeolite, hydroxyapatite, titanium mica, etc., granulated products thereof, granules of cellulose organic powder such as crystalline cellulose, agar, gelatin, starch , Natural polymer compounds such as glucomannan, synthetic polymer compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyvinyl chloride and copolymers thereof, carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, Waxes such as paraffin wax, higher alcohols such as cetanol and stearyl alcohol, latex rubbers such as polyisobutylene, polybutadiene, urethane, silicone, natural rubber, etc. obtained by crosslinking, polymerization, molding, etc., or these raw materials mixture Objects or lame film was collected using can be employed. Lame films include organic resin laminated film powder, laminated film powder in which a vapor deposition layer such as aluminum is introduced into the organic resin laminated film, specifically, polyethylene terephthalate / polymethyl methacrylate laminated film powder, polyethylene terephthalate・ Aluminum / epoxy laminated powder or the like can be blended within a range not impeding the effects of the present invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%. Moreover, 70% aqueous solution was used for sorbite, and 30% aqueous solution was used for N-lauroylmethyltaurine sodium, and the compounding amounts in the table shown below were expressed as pure amounts.

The dentifrice composition was prepared by the following production method.
(Production method)
(1) A phase was prepared by mixing and dissolving water-soluble components (excluding binder and propylene glycol) in purified water at room temperature.
(2) A phase B in which a binder was dispersed at room temperature in propylene glycol was prepared.
(3) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(4) In Phase C, ingredients other than water-soluble ingredients such as fragrances and abrasives are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kogakusho), defoamed under reduced pressure (4 kPa), and dentifrice The agent composition 1.2kg was obtained.

[Examples 1 to 19 and Comparative Examples 1 to 5]
A dentifrice composition (toothpaste) having the composition shown in Tables 3 and 4 was prepared by the above method, and the feeling of use (no taste at the time of brushing, no irritation, good foaming) was evaluated by the following method. The results are shown in Tables 3 and 4.

<Method for evaluating model biofilm bactericidal effect>
A 7 mm diameter hydroxyapatite (HA) plate was treated with human unstimulated saliva filtered through a 0.45 μm filter for 4 hours, and Streptococcus mutans, Actino in trypticase soy broth to which hemin and menadione were added. Cultivated by Actinomyces naeslundii, Bayonella parvula, Fusobacterium nucleatum, and Porphyromonas genivaris on Porphyromonas spp. A model biofilm was formed. Once a day after culturing for 2 weeks, artificial saliva (50 mmol / L KCl + 1 mmol / L KH ₂ PO ₄ +1 mmol / L CaCl ₂ +0.1 mmol / L MgCl ₂ (pH 7.0) was added to the dentifrice formulations shown in Tables 3 to 5 below. )) Was added twice as much and dispersed, and the centrifuged supernatant was used as a test drug solution. The model biofilm was immersed in the solution for 3 minutes and further cultured for 3 days. At the end of the culture, the model biofilm was taken out, dispersed, and cultured on an agar plate to determine the number of viable bacteria of each bacterial species in the model biofilm. Although the number of viable bacteria may fluctuate somewhat depending on the culture conditions, when artificial saliva is used instead of the test drug, it is about 8.5 log cfu (colony forming units / HA plate), less than 6.0 log cfu / HA plate In this case, it was judged that the biofilm sterilizing power was high. The evaluation criteria are shown below.
(Evaluation criteria for model biofilm bactericidal effect)
A: Less than 5.0 log cfu / HA plate O: More than 5.0 log cfu / HA plate to less than 6.0 log cfu / HA plate Δ: More than 6.0 log cfu / HA plate to less than 7.0 log cfu / HA plate ×: 7.0 log cfu / HA board or higher

<Feeling of use (no disgust)>
A sensory test using 10 expert panelists was conducted. About 1 g of the test dentifrice composition filled in a laminate tube with a diameter of 8 mm was placed on a commercial toothbrush and brushed for 3 minutes by the usual brushing method, and the unpleasant taste felt during use was evaluated according to the following ratings: did. An average value of the evaluation results of 10 persons was obtained, and those for which evaluations of ◎ and ◯ were ensured based on the following criteria were judged to be dentifrice compositions without taste.
(Score)
4 points: no disgusting 3 points: little disgusting 2 points: slightly disgusting 1 point: disgusting (judgment criteria for the average of the evaluation results of 10 professional panelists)
◎: 3.7 points to 4.0 points ◎ to ○: 3.3 points to less than 3.7 points ○: 3.0 points to less than 3.3 points Δ: 2.0 points to 3 points Less than 0 point x: Less than 2.0 point

<Feeling of use (no stimulation)>
Evaluation was conducted by a sensory test using 10 professional panelists. About 1 g of the test dentifrice composition filled in a laminated tube having a diameter of 8 mm was placed on a toothbrush, brushed for 3 minutes by a method of brushing normal teeth, and the absence of irritation during brushing was evaluated according to the following criteria. Judgment was made according to the following criteria from the average score of the results of 10 people.
(Score)
5 points: I do not feel stimulation 4 points: I feel almost no stimulation 3 points: I feel weak stimulation 2 points: I feel stimulation 1 point: I feel strong stimulation (Judgment criteria of the average value of the evaluation results of 10 professional panelists) )
◎: Average score is 4.5 or more and 5.0 or less ○: Average score is 4.0 or more and less than 4.5 △: Average score is 3.0 or more and less than 4.0 ×: Average score is Less than 3.0

<Usage (good foaming)>
A sensory test using 10 expert panelists was conducted. About 1 g of the test dentifrice composition filled in a laminate tube with a diameter of 8 mm was placed on a commercial toothbrush and brushed for 3 minutes by the usual brushing method. The foaming feeling felt during use was evaluated according to the following rating. . An average value of the evaluation results of 10 people was obtained, and those for which evaluations of ◎ and ○ were ensured based on the following criteria were judged to be dentifrice compositions with good foaming.
(Score)
5 points: Foaming is quite good 4 points: Foaming is good 3 points: Neither can be said 2 points: Foaming is bad 1 point: Foaming is quite bad (judgment criteria for the average of the evaluation results of 10 professional panelists)
◎: 4.5 points to 5.0 points ○: 4.0 points to less than 4.5 points △: 3.0 points to less than 4.0 points ×: less than 3.0 points

The raw materials and fragrance compositions used in the following examples are as follows.
Isopropylmethylphenol; 3-octanol manufactured by Osaka Chemical Co., Ltd .; 3-octyl acetate manufactured by Shiono Koryo Co., Ltd .; 3-octanone manufactured by Inoue Kako Co., Ltd .; Fencon manufactured by Inoue Kako Co., Ltd .; Anisaldehyde manufactured by Co., Ltd .; 1-octanol manufactured by Taiyo Perfume Co., Ltd .; N-lauroylmethyl taurine sodium solution (30% aqueous solution) manufactured by Takasago International Corporation;
LMT-30 manufactured by Nikko Chemicals Co., Ltd.
Sodium lauryl sulfate; manufactured by Toho Chemical Industry Co., Ltd. As fragrances, fragrance compositions A to I having the compositions shown in Tables 1 and 2 were prepared and blended. In addition, 3-octanol, 3-octyl acetate, 3-octanone, Fencon, and anisaldehyde are not included in the fragrance compositions shown in Tables 1 and 2.

From the results of Tables 3 and 4, when (A) isopropylmethylphenol is not contained, the biofilm bactericidal effect is inferior (Comparative Example 1). Even when other fragrances were added, taste was felt (Comparative Examples 2 and 3). (C) When the acylmethyl taurine salt was not contained, the foaming was inferior (Comparative Example 4), and when sodium lauryl sulfate was added, the foaming was good, but the irritation was strong and the usability was inferior (Comparative Example 5). On the other hand, the dentifrice compositions (Examples) containing the components (A) to (C) are excellent in biofilm sterilization effect and have a feeling of use (good foaming, unpleasant taste, and no irritation). It was found that the object of the present invention can be achieved. Further, Oite the examples in Table 3, the perfume composition A perfume composition or similar result be replaced by the B~I was obtained.

[Examples 20 to 38 ]
A toothpaste composition having the composition shown in Table 5 was prepared in the same manner as described above, and the feeling of use (no taste at the time of brushing, no irritation, good foaming) was evaluated by the following method. The results are shown in Table 5.
In the following examples, the components (A) to (C) were the same as those used in the above examples, and the following were used as anisaldehyde.
Anisaldehyde; manufactured by Taiyo Fragrance Co., Ltd.

From the results of Table 5, it was found that, when (D) anisaldehyde was added in addition to the components (A) to (C), the masking effect of the tasting taste derived from isopropylmethylphenol was further enhanced. Further, Oite the examples in Table 5, the perfume composition A perfume composition or similar result be replaced by the B~I was obtained.

From these results, by containing (A) isopropyl methylphenol, (B) 3-octanol, 3-octyl acetate, at least one fragrance component selected from 3-octanone, and (C) acyl taurine salt, It was found that a dentifrice composition excellent in oral biofilm sterilizing power and feeling of use (good foaming, unpleasant taste, and no irritation) can be realized.

Claims (3)

(A) 0.01-0.2% by mass of isopropylmethylphenol,
(B) 0.0004 to 0.1% by mass of at least one fragrance component selected from 3-octanol, 3-octyl acetate, and 3-octanone;
(C) A dentifrice composition comprising 0.1 to 5% by mass of an acyl taurine salt. Furthermore, according to claim 1 dentifrice composition, wherein the containing (D) anisaldehyde. (D) Dentifrice composition of Claim 2 containing 0.0001-0.1 mass% of component.