JP6322051B2 - Dentifrice composition - Google Patents

Description

  The present invention relates to a dentifrice composition.

  Allantoin and its derivatives are known to be useful active ingredients that activate cell functions and have anti-inflammatory and anti-ulcer effects. On the other hand, allantoin and its derivatives have the property of being easily hydrolyzed, and therefore their stability is extremely poor. Therefore, various studies have been made to improve the stability of allantoin and its derivatives in each field.

  For example, Patent Document 1 discloses that allantoin can be stably incorporated into an aqueous base material in an aqueous preparation containing an organic acid or inorganic acid, an amino acid, an alkali metal salt thereof, or a combination of two or more thereof together with allantoin. Is described. In Patent Document 2, in a composition for liquid oral cavity containing allantoin, the combination of citric acid and citrate, citric acid and alkali agent, or citrate and acid has an allantoin hydrolysis inhibiting effect at high temperature incubation. It is described that it has. Patent Document 3 describes that, in a composition for transparent liquid oral cavity containing allantoin, the pH can be maintained in a pH range that maintains the stability of allantoin by blending lactic acid.

  On the other hand, anionic surfactants are intended to provide foaming power, dirt (for example, plaque) removal power to dentifrice, or to assist bactericidal power (for example, isopropylmethylphenol). It is a useful ingredient to be blended.

JP-A 63-159317 JP 2010-143889 A JP20131651A

  However, when allantoin or a derivative thereof is added to a dentifrice, there is a problem that the stability of allantoin or a derivative thereof is not sufficient. Even if the pH of the dentifrice is adjusted by adding an acid, as in the aqueous preparations and solutions described in Patent Documents 1 to 3, the stability of allantoin or a derivative thereof is not sufficiently improved, and the cause is unknown. there were.

  An object of the present invention is to provide a dentifrice composition capable of maintaining the stability of allantoin and its derivatives, having good appearance stability and suppressing irritation in a dentifrice containing an allantoin and an anionic surfactant. Is to provide.

  The present inventors have intensively studied for improving the stability of the allantoin. In the process, it has been found that the stability of allantoin or a derivative thereof is not only related to pH, which is conventionally known, but also to the contents of sorbitol and glycerin as thickeners. However, when the amount of sorbitol and glycerin is suitable for stabilizing allantoin, it was found that when an anionic surfactant is added, precipitates are formed and the appearance stability of the dentifrice is impaired.

  As a result of further investigation by the present inventors to eliminate this problem, the content of glycerin in the dentifrice composition and the total content of glycerin and sorbitol are adjusted, and a predetermined amount of inorganic salt is added. The present inventors have found that allantoin and its derivatives are excellent in stability and can maintain appearance stability, and have reached the present invention.

That is, the present invention provides the following [1] to [2].
[1] Component (A): allantoin and / or a derivative thereof,
Component (B): anionic surfactant
Component (C): an inorganic salt having a solubility in purified water at 20 ° C. of 10 g / 100 mL to 500 g / 100 mL,
Component (D): Glycerin, or glycerin and sorbitol,
Containing
The ratio to the content of components of the content (C) of Ingredient (B) is from 0.03 to 60,
The content of component (D) with respect to the total amount of the dentifrice composition is 30% by mass to 60% by mass,
The content of the glycerin relative to the total amount of the dentifrice composition is 15% by mass to 60% by mass,
Dentifrice composition.
[2] The dentifrice composition according to [1], wherein component (B) is one or more anionic surfactants selected from acylamino acids, acyltaurines and salts thereof.

  According to the present invention, it is possible to provide a dentifrice composition in which decomposition of allantoin and / or a derivative thereof is suppressed, and at the same time, the appearance stability during storage is excellent and irritation is suppressed.

  The dentifrice composition of the present invention contains components (A) to (D). Each component will be sequentially described below.

[Component (A)]
Component (A) is allantoin and / or a derivative thereof.

  Examples of allantoin derivatives include allantoinchlorohydroxyaluminum and allantoindihydroxyaluminum.

  Allantoin and derivatives thereof may be synthesized according to a known scheme or may be commercially available.

  As the component (A), one or more selected from allantoin and allantoin derivatives can be selected and used.

  It is preferable that content of the component (A) in the dentifrice composition of this invention is 0.03 mass% or more with respect to the dentifrice composition whole quantity. Thereby, a periodontal disease disease inhibitory effect can fully be expressed.

  It is preferable that the upper limit of content of a component (A) is 0.5 mass% or less with respect to the dentifrice composition whole quantity. Thereby, the occurrence of astringency can be suppressed.

  In addition, in this invention, content of each component in a dentifrice composition is based on the preparation amount of each component at the time of manufacturing a composition unless there is particular notice.

[Component (B)]
Component (B) is an anionic surfactant.

  As an anionic surfactant, what has a C8-C18 saturated or unsaturated, linear or branched hydrocarbon group as a lipophilic group is preferable. The number of carbon atoms of the hydrocarbon group is more preferably 12-16. As the hydrophilic group, carboxylic acid, sulfonic acid, phosphoric acid, or a salt thereof is preferable. Specific examples of the anionic surfactant include α-olefin sulfonic acid such as sodium α-olefin sulfonate and / or its salt, alkyl sulfuric acid such as sodium lauryl sulfate and / or its salt, acylamino acid and / or its salt, acyl Examples include taurine and / or a salt thereof.

  The salt is not particularly limited as long as it is a pharmacologically acceptable salt. Pharmacologically acceptable salts include inorganic salts such as sodium salt, potassium salt, calcium salt, magnesium salt and ammonium salt; organic salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt. Can be mentioned. Among these salts, inorganic salts are preferable, alkali metal salts are more preferable, and sodium salts are still more preferable.

  Among the components (B), from the viewpoint of suppression of irritation to the oral mucosa, it is preferable to use one or more selected from the group consisting of acylamino acids, acyltaurines, and salts thereof, and acyltaurine and / or The salt is more preferred. The preferable component (A) can effectively suppress irritation in the acidic region.

  The acylamino acid refers to a compound in which an amino group hydrogen atom of an amino acid is substituted with an acyl group. The hydrogen atom of the amino group to which the acyl group is bonded may be further substituted with an alkyl group such as a methyl group.

  The acyl taurine refers to a compound in which the amino group hydrogen atom of taurine is substituted with an acyl group. The hydrogen atom of the amino group to which the acyl group is bonded may be further substituted with an alkyl group such as a methyl group.

  As R of the acyl group (RCO-) in the acylamino acid, a saturated or unsaturated, straight-chain or branched hydrocarbon group having 8 to 18 carbon atoms is preferable, and one having 12 to 16 carbon atoms is more preferable. .

  Examples of the amino acid in the acylamino acid include conventionally known amino acids. For example, glycine, alanine, glutamic acid, aspartic acid, the hydrogen of the amino group or imino group of these amino acids is substituted with an alkyl group (for example, a methyl group). And amino acid derivatives. As amino acids, N-methylalanine and glutamic acid are preferred.

  As the acylamino acid, lauroylglutamic acid, acylglutamic acid such as myristoylglutamic acid, and acylmethylalanine such as lauroylmethylalanine are preferable. Of these, acylglutamic acid is more preferred.

  The acyl group in the acylamino acid is preferably a saturated or unsaturated group having 8 to 18 carbon atoms, and more preferably 12 to 16 carbon atoms.

  The taurine in the acyl taurine may be a taurine derivative in which the hydrogen of the amino group is substituted with an alkyl group (for example, a methyl group). Examples of the taurine derivative include N-methyltaurine.

  As the acyl taurine, lauroyl methyl taurine, palm oil fatty acid methyl taurine, and myristoyl methyl taurine are preferable, and lauroyl methyl taurine is more preferable.

  Specific examples of the particularly preferred component (B) in the present invention include sodium lauroylmethyl taurate, sodium lauroyl glutamate, and sodium myristoyl glutamate, and more preferably one or more selected from these. . Since the taste of a dentifrice composition can be made favorable, a more preferable component (B) is lauroyl methyl taurine sodium.

  The content of the component (B) in the dentifrice composition of the present invention is preferably 0.3% by mass or more, and more preferably 0.5% by mass or more. Thereby, sufficient foaming power can be obtained.

  The upper limit of the content of component (B) is preferably 3% by mass or less, and more preferably 2% by mass or less, based on the total amount of the dentifrice composition. Thereby, irritation can be suppressed.

[Component (C)]
Component (C) is a water-soluble inorganic salt having a solubility in purified water at 20 ° C. of 10 g / 100 mL to 500 g / 100 mL.

Examples of such water-soluble inorganic salts, such as chloride, bromides, halide salts such as iodide, sulfate, and nitrate, and the like, chlorides, one selected from sulfates, and nitrates The above is preferable. As the salt, monovalent metal salts such as sodium salt and potassium salt, and divalent metal salts such as calcium salt, magnesium salt and zinc salt are preferable. Specific examples of the chloride include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and zinc chloride. Examples of the sulfate include sodium sulfate. An example of the nitrate is potassium nitrate.

  Component (C) is sodium chloride (solubility: 36 g / 100 mL), potassium chloride (solubility: 34 g / 100 mL), calcium chloride (solubility: 75 g / 100 mL), magnesium chloride (solubility: 55 g / 100 mL), zinc chloride (solubility) : 395 g / 100 mL), sodium sulfate (solubility: 20 g / 100 mL), and potassium nitrate (solubility: 32 g / 100 mL), preferably one or more selected from the group consisting of sodium chloride and sodium sulfate It is more preferable that it contains 1 type, or 2 or more types, sodium chloride and / or sodium sulfate is more preferable, and sodium sulfate is still more preferable. Thereby, a taste can be made favorable.

  The content of the component (C) with respect to the total amount of the dentifrice composition of the present invention is preferably 0.05% by mass or more, and more preferably 0.1% by mass or more. Thereby, sufficient appearance stability can be obtained. The upper limit of the content of the component (C) is preferably 12% by mass or less, more preferably 5% by mass or less, and further preferably 2% by mass or less. Thereby, irritation can be suppressed.

[(B) / (C)]
The ratio to the content of components of the content (C) of Ingredient (B) ((B) / (C)) is 0.03 or more, preferably 0.06 or more, 0.3 or more It is more preferable that Thereby, irritation can be suppressed. The upper limit of (B) / (C) is 60 or less, preferably 40 or less, and more preferably 20 or less. Thereby, appearance stability can be improved.

[Component (D)]
Component (D) is glycerin, or glycerin and sorbitol.

  Content of the component (D) with respect to the total amount of a dentifrice composition is 30 mass% or more, and it is preferable that it is 34 mass% or more. Thereby, sufficient component (A) stabilization effect can be acquired. The upper limit of content of a component (D) is 60 mass% or less, 55 mass% or less is preferable and 51 mass% or less is more preferable. Thereby, appearance stability can be maintained and irritation can be suppressed.

  The content of glycerin as component (D) with respect to the total amount of the dentifrice composition is 15% by mass or more, and preferably 20% by mass or more. Thereby, sufficient decomposition | disassembly inhibitory effect of a component (A) can be acquired. The upper limit of the content of glycerin is 60% by mass or less, preferably 55% by mass or less, and more preferably 51% by mass or less. Thereby, appearance stability can be maintained and irritation can be suppressed. Moreover, when a component (D) is only glycerol, it is preferable that it is 30 mass% or more.

  When component (D) contains sorbitol, the content of sorbitol relative to the total amount of the dentifrice composition is preferably 15% by mass or more, and the upper limit is preferably 35% by mass or less, and 30% by mass or less. More preferably. Thereby, sufficient component (A) stabilization effect can be acquired.

  When content of glycerol with respect to the whole quantity of a dentifrice composition is 30 mass% or more, it is preferable that a component (D) is only glycerol.

  The dentifrice composition of the present invention contains a known additive component (pharmacologically acceptable carrier) that can be used in the dentifrice composition within a range not impairing the effects of the present invention, in addition to the above-described components. May be. Examples of such additional components include abrasives, binders, thickeners (wetting agents), surfactants other than component (B), sweeteners, preservatives, fragrances, colorants, medicinal ingredients, pH adjusters. , Solvent, and oil component, and may be appropriately selected depending on the dosage form. Although the specific example of an additional component is shown below, the component which the dentifrice composition of this invention may contain is not restrict | limited to these.

  Examples of the abrasive include silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate. Examples thereof include dihydrate, calcium pyrophosphate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasive. Of these, anhydrous silicic acid and calcium hydrogen phosphate are preferred, and anhydrous silicic acid is more preferred.

  An abrasive | polishing agent can be used individually by 1 type or in combination of 2 or more types. When mix | blending an abrasive | polishing agent, it is preferable that the compounding quantity is 2 mass%-40 mass% of the whole dentifrice composition, and it is more preferable that it is 5 mass%-20 mass%.

  Examples of the binder include sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, sodium alginate, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, propylene glycol alginate, pullulan, gelatin, hydroxypropylcellulose, gum arabic, guar gum And organic binders such as locust bean gum, polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, and inorganic binders such as thickening silicic anhydride and bentonite.

  A binder can be used individually by 1 type or in combination of 2 or more types. The amount of the binder used is preferably 0.5% by mass to 10% by mass with respect to the total amount of the dentifrice composition.

  Examples of the thickener (wetting agent) include sugar alcohols such as xylitol, maltitol, and erythritol; and polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, polyethylene glycol, and polypropylene glycol. A thickener can be used individually by 1 type or in combination of 2 or more types. When using a thickener, the total content (total with a component (D)) can be defined in the range which does not prevent the effect of this invention, and is normally 30 mass%-with respect to the dentifrice composition whole quantity. 70% by mass.

  As the surfactant other than the component (B), for example, nonionic surfactants, amphoteric surfactants and the like can be used.

  Nonionic surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, glycerin ester polyoxyethylene ether, sucrose fatty acid ester, fatty acid alkylol Examples include amide, glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester and the like. Of these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, fatty acid alkylolamide, sorbitan fatty acid ester and the like are preferably used from the viewpoint of versatility. The polyoxyethylene alkyl ether preferably has a carbon chain length of 12 to 18 carbon atoms. The polyoxyethylene alkyl ether preferably has an average ethylene oxide addition mole number of 3 to 30. The polyoxyethylene hydrogenated castor oil preferably has an ethylene oxide average addition mole number (average addition EO) of 20 to 100. The fatty acid alkylolamide preferably has an alkyl chain with a carbon chain length of 12 to 14 carbon atoms. The sorbitan fatty acid ester preferably has 12 to 18 carbon atoms in the fatty acid. The polyoxyethylene sorbitan fatty acid ester preferably has 16 to 18 carbon atoms in the fatty acid. In addition, the polyoxyethylene sorbitan fatty acid ester preferably has an average ethylene oxide addition mole number of 10 to 40.

  Examples of amphoteric surfactants include alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples of the amphoteric surfactant include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkylbetaine, and coconut oil fatty acid amidopropyl betaine is preferred.

  The surfactant other than the component (B) may be used alone or in combination of two or more. When the dentifrice composition contains a surfactant other than the component (B), the total content of the content of the component (B) and the content of the surfactant other than the component (B) is the total amount of the dentifrice composition. It is preferable that it is 0.3 mass%-10 mass% with respect to.

  Examples of the sweetening agent include saccharin sodium, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, palatinose (registered trademark), maltitol, xylitol, arabitol and the like. One sweetener may be used alone, or two or more sweeteners may be used in combination. When using a sweetener, content can be suitably determined in the range which does not impair the effect of this invention.

  Examples of the preservative include paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, and butylparaben, ethylenediaminetetraacetate, benzalkonium chloride, and the like. One preservative may be used alone, or two or more preservatives may be used in combination. In the case of using a preservative, the content can be appropriately determined within a range not impairing the effects of the present invention.

  As a fragrance | flavor, the normal fragrance | flavor component which can be used for a formulation for oral cavity can be used individually or as a fragrance | flavor composition which combined multiple. It is preferable that content of a fragrance | flavor is 0.00001 mass%-3 mass% with respect to dentifrice composition whole quantity.

  Examples of the colorant include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red potato pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina pigment, tamarind pigment, and the like. Red 3, No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and other legal dyes, riboflavin, copper chlorofin sodium, titanium oxide, titanium dioxide, etc. Is mentioned. When a dentifrice composition contains a coloring agent, it is preferable that the content is 0.00001 mass%-3 mass% with respect to dentifrice composition whole quantity.

  Examples of the medicinal component include components other than the component (A), that is, the following components, for example: fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, strontium fluoride; Bactericidal or antibacterial agents such as cidin, triclosan, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride; condensed phosphates such as sodium pyrophosphate and sodium polyphosphate, zeolite, sodium monohydrogen phosphate and phosphoric acid Calculus preventive agents such as phosphates such as trisodium; anti-inflammatory agents such as tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, ε-aminocaproic acid, and buckwheat extract; astringents such as sodium chloride; Potassium nitrate, lactate al Examples include hypersensitivity inhibitors such as minium and strontium chloride; vitamins such as ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, and tocopherol acetate. One medicinal component may be used alone, or two or more medicinal components may be used in combination. When using a medicinal component, the content can be appropriately set within a pharmaceutically acceptable range for each medicinal component.

  Examples of the solvent include water and lower alcohols having 3 or less carbon atoms such as ethanol and propanol, and water is preferable. In addition, as a total water content contained in a dentifrice composition, 20 mass%-40 mass% are preferable.

  Examples of the pH adjuster include citric acid, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate. And acids such as sodium hydrogen citrate, sodium phosphate, sodium dihydrogen phosphate, and buffering agents. Of these, organic acids are preferred, and citric acid is more preferred. By using citric acid, the taste of the dentifrice composition can be improved. When using an organic acid, it is preferable to use an organic acid salt in addition to the organic acid, and it is more preferable to combine citric acid and sodium citrate. When using a pH adjuster, the content can be suitably determined within a range not impairing the effects of the present invention.

  The pH (20 ° C.) of the dentifrice composition of the present invention is preferably 4.5 or more, and more preferably 5.0 or more. Thereby, mucous membrane irritation can be suppressed. The upper limit of pH is preferably 6.2 or less, and more preferably 6.0 or less. Thereby, sufficient component (A) stabilization effect can be acquired.

  Examples of oil components include higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, isomyristic acid, isostearic acid, cholesteryl butyrate, cholesteryl stearate, cholesteryl isostearate, and phytosteryl isostearate. And fatty acid sterol esters such as cholesteryl hydroxystearate, cholesteryl oleate, and macadamia nut oil fatty acid cholesteryl. When a dentifrice composition contains an emulsifier, it is preferable that the content is 0.01 mass%-5 mass% with respect to the dentifrice composition whole quantity.

  EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to such examples. In the following, “%” means “mass%” unless otherwise specified.

[Main raw materials used in Examples , Reference Examples and Comparative Examples]
The main raw materials used in Examples , Reference Examples and Comparative Examples are described below.
<Component (A)>
Allantoin (manufactured by Permachem Asia)
Allanto chlorohydroxyaluminum (manufactured by Permachem Asia Co., Ltd., trade name "Alcloxa")
Allantoindihydroxyaluminum (manufactured by Permachem Asia, trade name “Arjiki”)
<Component (B)>
Lauroylmethyl taurine sodium (manufactured by Nikko Chemicals, trade name “NIKKOL LMT”)
<Ingredient (C)>
Sodium sulfate (solubility in purified water at 20 ° C .: 20 g / 100 mL)
Sodium chloride (solubility in purified water at 20 ° C .: 36 g / 100 mL)
<Component (D)>
85% glycerin (manufactured by Lion Chemical)
70% sorbitol (Rocket)

  As for other additive components, outer standard products were used.

Examples 1-3, 6-21, Reference Examples 1-2, and Comparative Examples 1-6
Using the above-mentioned components, a dentifrice composition (toothpaste) was prepared by the following preparation method according to the blending amounts shown in Tables 1 to 5. In addition, the compounding quantity of each component shown to Tables 1-5 is the value (AI) converted into a pure part except for 85% glycerol and 70% sorbitol liquid. The values (AI) in terms of pure content for 85% glycerin and 70% sorbitol solution are also shown in the table. The unit of each blending amount is mass%.

[Method for preparing dentifrice composition]
(1) Dissolve component (A), component (B), component (C), sodium fluoride, saccharin sodium, citric acid, sodium citrate in purified water, and further silicic anhydride (thickening), component (D) At room temperature and mixed (mixture X).
(2) Sodium carboxymethyl cellulose and sodium polyacrylate were dispersed in propylene glycol at room temperature (mixture Y). The mixture Z was prepared by adding and mixing titanium oxide and the mixture Y into the stirring mixture X.
(3) In the mixture Z, a fragrance | flavor and silicic acid anhydride (abrasiveness) are mixed at normal temperature using a kneader (product made from Miyagawa Shoten), defoaming by reduced pressure (5.3 kPa), and a dentifrice composition is obtained. It was.
The pH was measured using a pH meter (Mettler Toledo Co., Ltd. Seven Easy).

  The following test was done with respect to the obtained dentifrice composition.

(1) Evaluation method of decomposition inhibitory effect of allantoin and its derivatives About the dentifrice composition after 1 week preservation | save at 60 degreeC, the allantoin density | concentration was measured using the high performance liquid chromatography (HPLC) according to the following test conditions. The residual rate when the allantoin concentration immediately after the manufacture of each dentifrice composition was set to 100% was calculated, and the decomposition inhibition effect of allantoin was determined according to the following criteria.

<Test conditions>
・ Detector: UV absorption photometer (measurement wavelength: 210 nm)
Column: Inertsil NH ₂ (4.6 mmφ × 250 mm) (manufactured by GL Sciences)
-Column temperature: 35 ° C
Mobile phase: acetonitrile / phosphate buffer solution mixture (4: 1)
・ Flow rate: 1 mL / min
・ Phosphate buffer solution:
5.75 g of ammonium dihydrogen phosphate was dissolved in 750 mL of water, phosphoric acid was added to adjust the pH to 2.5, and water was added to make 1,000 mL.

<Devices used>
・ Pump: JASCO PU-980
・ Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X
-Detector: JASCO Corporation UV-970
Column thermostat: Senshu Science Co., Ltd. SCC-2100

<Criteria>
◎: Allantoin remaining rate is 95% or more and 100% or less ○: Allantoin remaining rate is 90% or more and less than 95% ×: Allantoin remaining rate is less than 90%

(2) Appearance Stability Evaluation Method After filling the dentifrice composition into a tube and storing it at 30 ° C. for 6 months, the appearance of the dentifrice composition at the mouth when the cap was removed was evaluated according to the following criteria. Among three tubes, the worst sample was evaluated.

<Evaluation criteria>
◎: No change in the appearance ○: Almost no change in the appearance ×: There are clear precipitates and the appearance is inferior

(3) Evaluation method of irritation to oral mucosa Four monitors evaluated the irritation in the oral cavity when the dentifrice composition was placed on a toothbrush and the oral cavity was washed according to the following evaluation criteria. The average of the four evaluation points was classified into the following criteria.

<Evaluation criteria>
4 points: I do not feel irritation in the oral cavity 3 points: I feel some stimulation in the oral cavity 2 points: I feel irritation in the oral cavity 1 point: I feel irritation very much in the oral cavity

<Criteria>
◎: Average point 3.5 points or more ○: Average point 2.5 points or more and less than 3.5 points △: Average point 2.0 to less than 2.5 ×: Average point less than 2.0 points

The composition and evaluation results of the dentifrice compositions (Examples 1 to 3 , 6 to 21, Reference Examples 1 to 2 and Comparative Examples 1 to 6) are shown in Tables 1 to 5 below.

(Footnotes in Tables 1-5)
*: Indicates a value converted into a pure content.

From Tables 1 to 5, the following can be understood. The dentifrice compositions of Examples 1 to 3 and 6 to 21 were excellent in all evaluations of the allantoin decomposition inhibitory effect, the appearance stability, and the irritation inhibitory effect on the oral mucosa. On the other hand, in Comparative Example 1 not including the component (C) and in Comparative Example 3 in which (B) / (C) exceeds 60, the appearance stability is inferior, and (B) / (C) is less than 0.03. In Comparative Example 2, irritation to the oral mucosa was high. Moreover, in the comparative example 4 whose content of glycerol is less than 15 mass%, and the comparative example 6 whose content of a component (D) is less than 30 mass%, the allantoin decomposition inhibitory effect was inferior. Furthermore, in Comparative Example 5 in which the component (D) exceeds 60% by mass, the appearance stability and irritation to the oral mucosa were high.

  These results show that in the dentifrice composition of the present invention, the decomposition of allantoin and its derivatives is suppressed, and at the same time, the appearance stability is excellent, the irritation is suppressed, and the usability is good. ing.

  Formulation examples of the dentifrice composition of the present invention are shown below.

[ Reference Formulation Example 1] Dentifrice Allantoin 0.1
Sodium lauryl sulfate 1.4
Sodium chloride 12
85% glycerin 25
70% sorbite solution 20
Citric acid 0.5
Sodium citrate 0.5
Isopropyl methylphenol 0.05
Cetylpyridinium chloride 0.05
Triclosan 0.02
Sodium fluoride 0.21
Tranexamic acid 0.05
Dipotassium glycyrrhizinate 0.2
Polyoxyethylene (20) hydrogenated castor oil 1.6
Propylene glycol 3
Sodium carboxymethylcellulose 1
Sodium polyacrylate 0.5
Propylene glycol alginate 0.1
Polyethylene glycol 4000 0.4
Saccharin sodium 0.18
Silicic anhydride (thickening) 5
Titanium oxide 0.1
Fragrance 1.28
Silicic anhydride (abrasive) 10
Isostearic acid 0.3
Phytosteryl isostearate 0.3
Water remaining
100% by mass

[Prescription Example 2] Dentifrice Allantoin 0.1
Myristoyl glutamate 1
Sodium sulfate 0.5
85% glycerin 40
Citric acid 0.7
Sodium citrate 0.5
Isopropyl methylphenol 0.05
Cetylpyridinium chloride 0.05
Triclosan 0.02
Sodium fluoride 0.21
β-glycyrrhetinic acid 0.2
ε-aminocaproic acid 0.2
Polyoxyethylene (20) hydrogenated castor oil 0.8
Polyoxyethylene (5) stearyl ether 0.8
Palm oil fatty acid amidopropyl betaine 1
Propylene glycol 3
Xanthan gum 1.5
Sodium alginate 0.5
Propylene glycol alginate 0.1
Polyethylene glycol 4000 0.4
Saccharin sodium 0.18
Silicic anhydride (thickening) 5
Titanium oxide 0.1
Fragrance 1.28
Calcium hydrogen phosphate 10
Isostearic acid 0.5
Phytosteryl isostearate 0.5
Water remaining
100% by mass

[Prescription Example 3] Dentifrice Allantoin 0.1
Lauroylmethyl taurine sodium 1.2
Sodium sulfate 0.5
85% glycerin 50
Citric acid 0.7
Sodium citrate 0.5
Isopropyl methylphenol 0.05
Cetylpyridinium chloride 0.05
Triclosan 0.02
Sodium fluoride 0.21
Tranexamic acid 0.05
Polyoxyethylene (20) hydrogenated castor oil 1.6
Propylene glycol 3
Sodium carboxymethylcellulose 1.2
Sodium polyacrylate 0.6
Propylene glycol alginate 0.1
Polyethylene glycol 4000 0.4
Saccharin sodium 0.18
Silicic anhydride (thickening) 5
Titanium oxide 0.1
Fragrance 1.28
Silicic anhydride (abrasive) 10
Isostearic acid 0.1
Phytosteryl isostearate 0.1
Water remaining
100% by mass

[ Reference Formulation Example 4] Dentifrice Allantoin 0.1
Lauroylmethyl taurine sodium 0.6
Sodium lauryl sulfate 0.6
Sodium chloride 0.5
85% glycerin 25
70% sorbit solution 25
Citric acid 0.7
Sodium citrate 0.5
Isopropyl methylphenol 0.05
Cetylpyridinium chloride 0.05
Triclosan 0.02
Sodium fluoride 0.21
β-glycyrrhetinic acid 0.2
ε-aminocaproic acid 0.2
Polyoxyethylene (20) hydrogenated castor oil 1.6
Propylene glycol 3
Sodium carboxymethylcellulose 1
Sodium polyacrylate 0.6
Sodium alginate 0.5
Propylene glycol alginate 0.1
Polyethylene glycol 4000 0.4
Saccharin sodium 0.18
Silicic anhydride (thickening) 5
Titanium oxide 0.1
Fragrance 1.28
Silicic anhydride (abrasive) 15
Isostearic acid 0.1
Phytosteryl isostearate 0.1
Water remaining
100% by mass

Claims (6)

Component (A): one or more selected from the group consisting of allantoin, allantoinchlorohydroxyaluminum, and allantoindihydroxyaluminum,
Component (B): One or more anions selected from the group consisting of acyl glutamic acid having an acyl group having 12 to 16 carbon atoms , acyl taurine having an acyl group having 12 to 16 carbon atoms , and salts thereof Surfactant,
Component (C): 20 1, two or more inorganic salts solubility Bareru 10g / 100mL~500g / 100mL der Ru sulfate salt or al election to purified water in ° C.,
Component (D): Glycerin, or glycerin and sorbitol,
Containing
The ratio of the content of component (B) to the content of component (C) is 0.03-60,
The content of component (D) with respect to the total amount of the dentifrice composition is 30% by mass to 60% by mass,
The content of the glycerin relative to the total amount of the dentifrice composition is 15% by mass to 60% by mass,
Dentifrice composition. The content of the component (B) is 0.3% by mass to 3% by mass and the content of the component (C) is 0.05% by mass to 12% by mass with respect to the total amount of the dentifrice composition. The dentifrice composition of Claim 1 satisfy | filling at least any one of these .   The dentifrice composition of Claim 1 or 2 whose component (C) is 1 type, or 2 or more types chosen from monovalent metal salt and bivalent metal salt.   The dentifrice composition of any one of Claims 1-3 whose water content with respect to the whole quantity in a dentifrice composition is 20 mass%-40 mass%.   The dentifrice composition of any one of Claims 1-4 whose pH in 20 degreeC is 4.5-6.2.   The dentifrice composition according to any one of claims 1 to 5, which is a toothpaste.