KR102378034B1 - Toothpaste composition - Google Patents

Abstract

In the present invention, component (A): allantoin and/or derivatives thereof, component (B): one or more organic acids selected from the group consisting of citric acid, malic acid, tartaric acid, and phytic acid, component (C): glycerin, And Component (D): A dentifrice composition including water, wherein the content of the component (C) is 30% by mass to 60% by mass, and the content of the component (D) is 20% by mass to 50% by mass with respect to the total amount of the dentifrice composition provides The said dentifrice composition may contain the 1 type(s) or 2 or more types of abrasive|polishing agents chosen from the group which consists of component (E): silicic anhydride and calcium hydrogenphosphate further.

Description

skirt composition {TOOTHPASTE COMPOSITION}

The present invention relates to a skirt composition.

Conventionally, it has been known that allantoin and its derivatives are useful active ingredients that activate cell functions and have anti-inflammatory and anti-ulcer effects.

On the other hand, since allantoin and its derivatives have a property of being easily hydrolyzed, their stability is extremely poor. Therefore, various examinations are made in each field.

For example, Patent Document 1 describes that, in an aqueous formulation containing allantoin, an organic or inorganic acid, an amino acid, an alkali metal salt thereof, or a combination of two or more thereof is used to stably blend allantoin into an aqueous substrate. there is. Patent Document 2 describes that, in a liquid oral composition containing allantoin, a combination of citric acid and citric acid, citric acid and an alkali agent, or citrate and an acid has an allantoin hydrolysis inhibitory effect at high temperature retention. Patent Document 3 describes that the pH can be maintained within a pH range that maintains the stability of allantoin by blending lactic acid in a transparent liquid composition for oral cavity containing allantoin.

A dentifrice used for the purpose of being put on applicators, such as a toothbrush, and used for oral cleaning, requires moderate viscosity, and while suppressing stringiness, solidification of a paste It is required to suppress and maintain dispersibility. In order to maintain such usability, viscous agents, such as sorbit, have been conventionally mix|blended with dentifrice.

Patent Document 1: Japanese Patent Laid-Open No. 63-159317 Patent Document 2: Japanese Patent Laid-Open No. 2010-143889 Patent Document 3: Japanese Patent Laid-Open No. 2013-1651

However, when allantoin or a derivative thereof is blended with dentifrice, there is a problem that the stability of allantoin or a derivative thereof is insufficient. Even if the pH of the dentifrice was adjusted by adding an acid as in Patent Documents 1 to 3, the stability of allantoin or its derivative was not sufficiently improved, and the cause was not clear.

An object of the present invention is to provide a dentifrice composition capable of maintaining the stability of allantoin and its derivatives and not impairing the usability.

MEANS TO SOLVE THE PROBLEM The present inventors repeated earnest examination in order to solve the said subject. In the process, it discovered that the water content and sorbit had influence on the stability of allantoin or its derivative(s).

Then, the present inventors discovered that the said subject could be solved by containing glycerol as a viscous agent in a specific amount as a viscous agent in the dentifrice containing allantoin or its derivative(s) and a specific organic acid, and also specifying the moisture content, and discovered, and the present invention reached

The present invention provides the following [1] to [7].

[1] Component (A): Allantoin and/or its derivatives, Component (B): One or more organic acids selected from the group consisting of citric acid, malic acid, tartaric acid, and phytic acid, and Component (C): glycerin; and component (D): water, the content of the component (C) is 30% by mass to 60% by mass, and the content of the component (D) is 20% by mass to 50% by mass relative to the total amount of the skirt composition, the skirt composition.

[2] Component (E): The skirt composition according to the above [1], further comprising one or more abrasives selected from the group consisting of silicic anhydride and calcium hydrogen phosphate.

[3] The skirt composition according to the above [1] or [2], containing an anionic surfactant.

[4] The dentifrice composition according to the above [3], wherein the anionic surfactant contains at least one selected from acylamino acids, acyltaurines and salts thereof.

[5] The dentifrice composition according to the above [3] or [4], which contains a water-soluble inorganic salt having a solubility in purified water at 20°C of 10 g/100 ml to 500 g/100 ml.

[6] Further, a fatty acid having a branched chain structure having 8 to 22 carbon atoms, a fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms, and a polyglycerol fatty acid ester represented by the following formula (1):

RO-(C ₃ H ₆ O ₂ R) _n R (1)

[In formula (1), R represents a C5-C25 branched alkyl group or alkenyl group which may have a hydroxyl group. n represents the average degree of polymerization of glycerin, and is 1 to 20.]

The skirt composition according to any one of [1] to [5], which contains at least one selected from the group consisting of.

[7] One or more chelating agents selected from the group consisting of the following (J1) to (J2):

(J1): Condensed phosphoric acid and its salt having a pH of 1 to 5 in a 1% aqueous solution at 25°C;

(J2): The skirt composition according to any one of [1] to [6] above, comprising edetic acid and a salt thereof.

ADVANTAGE OF THE INVENTION According to this invention, while containing allantoin and/or its derivative(s) stably, a dentifrice composition with favorable usability can be provided.

The dentifrice composition of the present invention comprises, component (A): allantoin and/or derivatives thereof, component (B): one or more organic acids selected from the group consisting of citric acid, malic acid, tartaric acid, and phytic acid, and component (C) ): glycerin, and component (D): water, with respect to the total amount of the dentifrice composition, the content of the component (C) is 30% by mass to 60% by mass, and the content of the component (D) is 20% by mass to 50% by mass %am.

ADVANTAGE OF THE INVENTION According to this invention, while containing allantoin and/or its derivative(s) stably, a dentifrice composition with favorable usability can be provided.

The dentifrice composition of this invention may contain the 1 type(s) or 2 or more types of abrasive|polishing agents chosen from the group which consists of component (E): silicic anhydride and calcium hydrogenphosphate further. If it is set as such a structure, sufficient component (A) stabilizing effect can be acquired.

The dentifrice composition of this invention may contain the anionic surfactant.

With such a structure, the usability can be improved while suppressing the decomposition of allantoin and its derivatives.

In this invention, the anionic surfactant may contain 1 or more types chosen from acylamino acid, acyltaurine, and these salts.

With such a structure, irritation in an acidic region can be suppressed without impairing usability.

The dentifrice composition of this invention may contain the inorganic salt whose solubility with respect to the purified water in 20 degreeC is 10 g/100 ml - 500 g/100 ml.

When the compounding quantity of glycerol is made into the range suitable for stabilization of allantoin, when an anionic surfactant is mix|blended, a precipitate may arise and the external appearance stability of a dentifrice may be impaired. Then, if it is set as the structure as mentioned above, the stability of allantoin and its derivative(s) can be maintained in the dentifrice containing allantoin and anionic surfactant, and also the dentifrice composition with favorable external appearance stability can be provided.

The dentifrice composition further comprises a fatty acid having a branched chain structure having 8 to 22 carbon atoms, a fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms, and polyglycerol represented by the following formula (1) Fatty acid ester:

RO-(C ₃ H ₆ O ₂ R) _n R (1)

[In formula (1), R represents a C5-C25 branched alkyl group or alkenyl group which may have a hydroxyl group. n represents the average degree of polymerization of glycerin, and is 1 to 20.]

You may contain at least 1 sort(s) selected from the group which consists of.

It is different from the skin in that the oral cavity is always wet with saliva, and there are many cases of mouth sores after application of the formulation, so it is difficult to retain or absorb water-soluble ingredients on the wet gum surface or inside the gums. there is.

Then, when it sets as the structure as mentioned above, the dentifrice composition with improved retention and water absorption in oral tissues, especially gums of allantoin can be provided.

The dentifrice composition of the present invention comprises (J1): condensed phosphoric acid and a salt thereof having a pH of 1 to 5 at 25°C in a 1% aqueous solution, and (J2): one selected from the group consisting of edetic acid and a salt thereof; You may contain 2 or more types of chelating agents.

According to the said structure, while containing allantoin and/or its derivative(s) stably, it has a stain removal effect, and can provide the dentifrice composition with favorable usability.

The dentifrice composition of this invention contains a component (A)-(D), and may contain a component (E) further. Each component will be sequentially described below.

[Component (A)]

A component (A) is allantoin and/or its derivative(s), 1 type(s) or 2 or more types can be selected and used from these.

Examples of the derivative of allantoin include allantoin chlorhydroxyaluminum and allantoindihydroxyaluminum.

It is preferable that content of a component (A) is 0.03 mass % - 0.5 mass % with respect to dentifrice composition whole quantity. If it is 0.03 mass % or more, the periodontal disease inhibitory effect can fully be expressed. Moreover, generation|occurrence|production of an astringency can be suppressed by setting it as 0.5 mass % or less.

In addition, in this invention, content of each component in a dentifrice composition is based on the preparation amount of each component at the time of manufacturing a composition, unless there is a notice in particular.

[Component (B)]

Component (B) in the present invention is one or more organic acids selected from the group consisting of citric acid, malic acid, tartaric acid, and phytic acid.

It is preferable that a component (B) contains citric acid at least. It is preferable that it is 20-100 mass %, as for the ratio of the citric acid in a component (B), it is more preferable that it is 50-100 mass %, It is still more preferable that it is citric acid independent. Thereby, an oral composition can show favorable taste.

It is preferable that it is 0.1 mass % or more with respect to the dentifrice composition whole quantity, and, as for content of the component (B) in the dentifrice composition of this invention, it is more preferable that it is 0.3 mass % or more. Thereby, sufficient component (A) stabilizing effect can be acquired.

Although there is no restriction|limiting in particular in the upper limit of content of a component (B), It is preferable that it is 3 mass % or less with respect to dentifrice composition whole quantity, and it is more preferable that it is 2 mass % or less. Thereby, acidity can be suppressed and favorable usability can be exhibited.

Moreover, in addition to component (B), it is preferable to contain the metal salt of the said organic acid further. As a metal salt of each said acid, a sodium salt, a potassium salt, and a calcium salt are preferable. A more preferable combination is citric acid and sodium citrate. 0.1 mass % or more is preferable with respect to the dentifrice composition whole quantity from the point of a component (A) stabilizing effect, as for total content of the metal salt of the said organic acid, 0.2 mass % or more is more preferable, 0.3 mass % is more preferable than Moreover, from the point of acidity suppression, 6 mass % or less is preferable, 5 mass % or less is more preferable, 3 mass % or less is still more preferable.

[Component (B)/Component (A)]

The ratio of the content of the component (B) to the content of the component (A) (hereinafter, abbreviated as component (B)/component (A)) is preferably 1 to 50, and 2 to 30 more preferably. Thereby, coexistence of the sufficient component (A) stabilizing effect and the favorable usability which suppressed acidity is attained.

[Component (C)]

Component (C) is glycerin.

Content of component (C) in the dentifrice composition of this invention is 30 mass % or more with respect to dentifrice composition whole quantity, It is preferable that it is 34 mass % or more, It is more preferable that it is 40 mass % or more. Thereby, sufficient component (A) stabilizing effect can be acquired.

It is 60 mass % or less with respect to dentifrice composition whole quantity, and, as for the upper limit of content of a component (C), it is preferable that it is 55 mass % or less, and it is more preferable that it is 51 mass % or less. Thereby, stringiness can be suppressed and intraoral dispersibility can be exhibited.

[Component (C)/Component (A)]

It is preferable that it is 50-8000, and, as for the ratio of content of component (C) with respect to content of component (A) (it abbreviates hereafter as component (C)/component (A).), it is more preferable that it is 100-5000 Do. Thereby, sufficient component (A) stabilizing effect can be acquired.

[Ingredient (D)]

Component (D) is water.

Content of the component (D) in the dentifrice composition of this invention is 20 mass % or more with respect to dentifrice composition whole quantity, and it is preferable that it is 25 mass % or more. Thereby, stringiness can be suppressed and intraoral dispersibility can be exhibited.

It is 50 mass % or less with respect to dentifrice composition whole quantity, and, as for the upper limit of content of a component (D), it is preferable that it is 45 mass % or less, and it is more preferable that it is 40 mass % or less. Thereby, sufficient component (A) stabilizing effect can be acquired.

In addition, content of the said component (D) means the total moisture content in a dentifrice composition.

[Ingredient (E)]

Component (E) is a 1 type(s) or 2 or more types of abrasive|polishing agent chosen from the group which consists of silicic anhydride and calcium hydrogenphosphate. In addition, silicic anhydride as an abrasive|polishing agent may be called "abrasive silica" hereafter.

The liquid absorption amount of the abrasive silica is usually 0.5 ml/g to 2.0 ml/g, preferably 0.7 ml/g to 1.5 ml/g.

In the present invention, the liquid absorption is a value measured by the following method. That is, 1 g of the sample is weighed on a glass plate, and the 42.5 mass % glycerin aqueous solution is added dropwise using a burette, while mixing with a spatula so that the liquid becomes uniform. The time when the sample becomes a single lump and is peeled cleanly from the glass plate with a spatula is taken as the end point, and the amount of glycerin aqueous solution required for 1.0 g of the sample is expressed as the amount of absorption (ml/g).

The component (E) may be any of silicic anhydride, calcium hydrogen phosphate, and combinations thereof, but is preferably silicic anhydride or calcium hydrogen phosphate, more preferably silicic anhydride. Thereby, sufficient component (A) stabilizing effect can be acquired.

When the dentifrice composition of this invention contains a component (E), it is preferable that content of a component (E) is 5 mass % or more with respect to dentifrice composition whole quantity. Thereby, the cleaning power with respect to colored substances, such as a stain, becomes remarkably favorable and is obtained.

Although there is no restriction|limiting in particular in the upper limit of content of a component (E), It is preferable that it is 30 mass % or less with respect to dentifrice composition whole quantity, and it is more preferable that it is 20 mass % or less. Thereby, sufficient component (A) stabilizing effect can be acquired.

The dentifrice composition of this invention, in addition to the said component, further an anionic surfactant [component (F)], a water-soluble inorganic salt [component (G)], a fatty acid which has a C8-C22 branched chain structure, C8-22 At least one selected from the group consisting of fatty acid esters having a linear or branched chain structure, and polyglycerol fatty acid esters represented by the formula (1) [component (H)], and a chelating agent [component (J)] It may contain 1 or more types of components selected from. Each component will be sequentially described below.

[Component (F)]

A component (F) is an anionic surfactant.

The anionic surfactant preferably has, as a lipophilic group, a saturated or unsaturated, linear or branched hydrocarbon group having 8 to 18 carbon atoms. As for carbon number of a hydrocarbon group, it is more preferable that it is 12-16. As the hydrophilic group, carboxylic acid, sulfonic acid, phosphoric acid, or a salt thereof is preferable. Specific examples of the anionic surfactant include α-olefinsulfonic acids and/or salts thereof such as sodium α-olefinsulfonate, alkyl sulfuric acids and/or salts thereof such as sodium lauryl sulfate, and acylamino acids and/or salts thereof such as sodium acylglutamate , acyltaurine and/or a salt thereof, and the like are exemplified.

As said salt, each pharmacologically acceptable salt may be sufficient, and it is not specifically limited. Examples of the pharmacologically acceptable salt include inorganic salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; and organic salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt. Among these salts, inorganic salts are preferable, alkali metal salts are more preferable, and sodium salts are still more preferable.

Among the component (F), it is preferable to use one or two or more selected from the group consisting of acylamino acids, acyltaurine, and salts thereof from the viewpoint of suppressing irritation to the oral mucosa, and acyltaurine and/or its A salt is more preferable. The preferable component (F) can effectively suppress irritation in an acidic region.

As R of the acyl group (RCO-) in the said acylamino acid, a C8-C18 saturated or unsaturated, linear or branched hydrocarbon group is preferable, and a C12-C16 thing is more preferable.

As a specific acyl group, for example, octanoyl group, nonanoyl group, decanoyl group, undecanoyl group, lauroyl group, tridecanoyl group, myristoyl group, pentadecanoyl group, palmitoyl group, heptadecanoyl group , a stearoyl group, an oleoyl group, a nonadecanoyl group, and an icosanoyl group.

Among the above, lauroyl group, tridecanoyl group, myristoyl group, pentadecanoyl group, and palmitoyl group are more preferable, and lauroyl group or myristoyl group is still more preferable.

Examples of the amino acid in the acylamino acid include glycine, alanine, glutamic acid, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, aspartic acid, glutamine, proline, phenylalanine, tyrosine, tryptophan, and the like; Further, examples of amino acid derivatives in which the amino group or imino group of these amino acids is substituted with an alkyl group having 1 to 3 carbon atoms (eg, a methyl group) include N-methylalanine and glutamic acid.

As an acyl amino acid, acyl glutamic acids, such as lauroyl glutamic acid and myristoyl glutamic acid, and acyl methyl alanine, such as lauroyl methyl alanine, are preferable. Among these, acyl glutamic acid is more preferable.

The taurine in acyl taurine may be a taurine derivative in which hydrogen in the amino group is substituted with an alkyl group having 1 to 3 carbon atoms (eg, a methyl group). Examples of the taurine derivative include N-methyltaurine.

As acyl taurine, lauroyl methyl taurine, palm oil fatty acid methyl taurine, and myristoyl methyl taurine are preferable, and lauroyl methyl taurine is more preferable.

As a more preferable component (F) in this invention, specifically, sodium lauroyl methyl taurine, sodium lauroyl glutamate, and sodium myristoyl glutamate are mentioned, 1 type(s) or 2 or more types selected from these are mentioned. more preferably. Since the penetration sterilization power with respect to the biofilm of a dentifrice composition can be raised and a taste can be made favorable, a more preferable component (F) is sodium lauroyl methyl taurine.

A component (F) can be used combining said each component 1 type or 2 or more types.

It is preferable that it is 0.3 mass % or more, and, as for content of the component (F) in the dentifrice composition of this invention, it is more preferable that it is 0.5 mass % or more. Thereby, sufficient foaming force can be acquired.

It is preferable that it is 3 mass % or less with respect to dentifrice composition whole quantity, and, as for the upper limit of content of a component (F), it is more preferable that it is 2.5 mass % or less, It is still more preferable that it is 2 mass % or less. Thereby, irritation can be suppressed.

[Ingredient (G)]

Component (G) is a water-soluble inorganic salt having a solubility of 10 g/100 ml to 500 g/100 ml in purified water at 20°C.

Examples of such water-soluble inorganic salts include halide salts such as chloride salts, bromide salts and iodide salts, sulfate salts, and nitrates, and at least one selected from chloride salts, sulfate salts, and nitrates. desirable. As a salt, monovalent metal salts, such as a sodium salt and potassium salt, and divalent metal salts, such as a calcium salt, a magnesium salt, and a zinc salt, are preferable. Specific examples of the chloride salt include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and zinc chloride. As the sulfate, sodium sulfate is exemplified. Potassium nitrate is illustrated as a nitrate.

Component (G) is sodium chloride (solubility: 36 g/100 ml), potassium chloride (solubility: 34 g/100 ml), calcium chloride (solubility: 75 g/100 ml), magnesium chloride (solubility: 55 g/100 ml), zinc chloride ( Solubility: 395 g/100 ml), sodium sulfate (solubility: 20 g/100 ml), and potassium nitrate (solubility: 32 g/100 ml), preferably containing one or two or more selected from the group consisting of sodium chloride and It is still more preferable that it is/or sodium sulfate, and it is still more preferable that it is sodium sulfate from a taste point.

It is preferable that it is 0.05 mass % or more, and, as for content of the component (G) with respect to whole quantity of the dentifrice composition of this invention, it is more preferable that it is 0.1 mass % or more. Thereby, sufficient external appearance stability can be acquired. 12 mass % or less is preferable, as for the upper limit of content of component (G), it is more preferable that it is 5 mass % or less, It is still more preferable that it is 2 mass % or less. Thereby, irritation can be suppressed.

[(F)/(G)]

The ratio ((F)/(G)) of the content of the component (G) to the content of the component (F) with respect to the total amount of the dentifrice composition is 0.03 or more, preferably 0.06 or more, and more preferably 0.3 or more. . Thereby, irritation can be suppressed. (F) The upper limit of /(G) is 60 or less, 40 or less are preferable, and 20 or less are more preferable. Thereby, external appearance stability can be improved.

[Ingredient (H)]

(H) Since mixing|blending of a component can make the tissue retention property in oral cavity of allantoin and water absorption higher, it is preferable. The component [H] is selected from the group consisting of a fatty acid having a branched chain structure having 8 to 22 carbon atoms, a fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms, and a polyglycerol fatty acid ester represented by the formula (1). There is at least one

<A fatty acid having a branched chain structure having 8 to 22 carbon atoms>

Although it does not specifically limit as said fatty acid which has a C8-C22 branched structure, For example, isodecanoic acid, isotridecanoic acid, isomyristinic acid,

Isopalmitic acid, isostearic acid, etc. are mentioned. Among the above fatty acids, a higher fatty acid having 12 to 20 carbon atoms with high skin affinity is preferable, and isostearic acid is more preferable.

Although it does not specifically limit as a compounding quantity with respect to the whole quantity of the said fatty acid dentifrice composition, 0.01 mass % or more with higher allantoin retention and absorption effect is preferable, More preferably, it is 0.05 mass % or more. Moreover, as for an upper limit, it is preferable to set it as 1 mass % or less with more favorable taste, a smell, and a flavor, 0.3 mass % or less is more preferable, and its 0.2 mass % or less is still more preferable.

<A fatty acid ester having a linear or branched structure having 8 to 22 carbon atoms>.

Although it does not specifically limit as said fatty acid ester which has a C8-C22 linear or branched structure, It is preferable that a fatty acid residue has a branched structure. A C12-C20 thing is more preferable. Even more preferable fatty acid ester is isostearic acid ester. Moreover, as a kind of ester, the sterol ester which has a sterol skeleton is preferable, and among these, a phytosterol ester and a cholesterol ester are preferable, and a phytosterol ester is still more preferable. Specific examples of fatty acid esters include N such as N-lauroyl-L-glutamic acid di(cholesteryl/octyldodecyl) and N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl). -Acylamino acid sterol ester, butyrate cholesterol, cholesteryl stearate, cholesteryl isostearate, phytosteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, macadamia nuts milk fatty acid cholesterol Fatty acid sterol esters, such as a reel, are mentioned, Phytosteryl isostearate is more preferable.

Although it does not specifically limit as a compounding quantity of the said fatty acid ester, 0.01 mass % or more with higher retention and absorption effect of allantoin is preferable, and 0.05 mass % or more is still more preferable. From points, such as a taste, a smell, and a flavor, 1 mass % or less is preferable, 0.3 mass % or less is more preferable, and, as for an upper limit, 0.2 mass % or less is still more preferable.

<Polyglycerol fatty acid ester represented by Formula (1)>

Polyglycerol fatty acid ester represented by Formula (1) has the following structures.

RO-(C ₃ H ₆ O ₂ R) _n R (1)

In formula (1), R represents a C5-C25 branched alkyl group or alkenyl group which may have a hydroxyl group. As carbon number of R, 5-20 are more preferable, and 10-20 are still more preferable.

In formula (1), n shows the average degree of polymerization of glycerol, and is 1-20 normally, 1-15 are preferable and 1-12 are more preferable.

Examples of the fatty acid ester represented by the formula (1) include polyglyceryl monoisostearate, polyglyceryl diisostearate, hexaglyceryl polyricinoleate, etc., but It is preferable that it is hexaglyceryl polyricinoleate from a viewpoint of chemical conversion and oral use.

Although it does not specifically limit as a compounding quantity of the fatty acid ester represented by said Formula (1), 0.01 mass % or more with a higher retention and absorption effect of allantoin is preferable, and 0.05 mass % or more is more preferable. From points, such as a taste, a smell, and a flavor, 1 mass % or less is preferable, 0.3 mass % or less is more preferable, and, as for an upper limit, 0.2 mass % or less is still more preferable.

(H)component in this invention can use 1 type or 2 or more types together. As two or more types of combined use, it is preferable to use together the fatty acid having a branched chain structure having 8 to 22 carbon atoms and a fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms, and isostearic acid and phytosteryl isostearate are used in combination. It is more preferable to use together. At that time, the mixing ratio of each component (fatty acid having a branched chain structure of 8 to 22 carbon atoms: fatty acid ester having a straight chain or branched chain structure having 8 to 22 carbon atoms) is preferably 1:5 to 5:1 by mass. .

The total amount of the fatty acid having a branched chain structure having 8 to 22 carbon atoms and the fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms is preferably 0.01 to 2 mass%, more preferably 0.02 to 1 mass%, , 0.02-0.5 mass % is still more preferable.

[Ingredient (J)]

In the present invention, component (J) is one or more chelating agents selected from the group consisting of the following (J1) to (J2):

(J1): Condensed phosphoric acid and its salt having a pH of 1 to 5 in a 1% aqueous solution at 25°C;

(J2) Edetic acid and its salts

Although the kind of salt in each of (J1) and (J2) is not specifically limited, Metal salts, such as a sodium salt and potassium salt, are illustrated. The salt is preferably a sodium salt.

In (J1), it is preferable that it is 5 or less, and, as for the pH at 25 degreeC of condensed phosphoric acid and its salt, it is more preferable that it is pH 3 or less. Thereby, the chelating effect can be exhibited under acidic conditions. The lower limit is not particularly limited, and may be 1 or more.

As condensed phosphoric acid and its salt, the general formula: H _{x + 2} P _x O _{3x +1} [x≥1], M _x H _x P _x O _{3x +1} [x≥1], H(PO ₃ ) _x [x ≥1], M _x H _y (PO ₃ ) _{x +y} [x, y ≥ 1] may be mentioned (where M represents a metal ion), among them, sodium metaphosphate, fatigue Disodium dihydrogen phosphate is preferable, and sodium metaphosphate is more preferable.

As (J1), metaphosphoric acid and its salt and disodium dihydrogen pyrophosphate whose pH at 25 degreeC in 1% aqueous solution is 1-5 are preferable, and metaphosphoric acid and its salt are more preferable.

(J2) is preferably a salt of edetic acid, and preferably disodium edetic acid.

Each of (J1) to (J2) may be one type or two or more types. (J1) is preferable, and metaphosphoric acid and/or a salt thereof having a pH of 1 to 5 in a 1% aqueous solution at 25°C is even more preferable. Thereby, the stain removal effect and usability can be improved more.

It is preferable that it is 0.1 mass % or more with respect to the dentifrice composition whole quantity, and, as for content of the component (J) in the dentifrice composition of this invention, it is more preferable that it is 0.2 mass % or more. Thereby, a stain removal effect can be acquired.

It is preferable that it is 3 mass % or less with respect to dentifrice composition whole quantity, and, as for the upper limit of content of component (J), it is more preferable that it is 2 mass % or less. Thereby, irritation can be suppressed and favorable usability can be exhibited.

The dosage form of the dentifrice composition of this invention is not specifically limited, A paste form, liquid etc. are illustrated. The skirt composition prepared in the above formulation can be made into various skirt products such as a soft skirt, a liquid skirt, and a gel skirt. A preferred product form of the present invention is a ruffle skirt.

The dentifrice composition of the present invention may contain, in addition to each of the above components, a known additive component (pharmacologically acceptable carrier) that can be used in the dentifrice composition within a range that does not impair the effects of the present invention. As these additive components, for example, an abrasive other than component (E), a binder, a viscous agent (wetting agent), surfactant other than component (F), a sweetener, a preservative, a fragrance|flavor, a coloring agent, a medicinal component, a pH adjuster, a solvent , and may be appropriately selected depending on the formulation. Although the specific example of an additive component is shown below, the component which may be contained in the dentifrice composition of this invention is not restrict|limited to these.

Examples of the abrasive (other abrasive) other than the component (E) include inorganic abrasives such as zeolite, calcium pyrophosphate, aluminum hydroxide, alumina, hydroxyapatite, magnesium carbonate, magnesium triphosphate, zirconium silicate, crystalline cellulose, etc. and synthetic resin-based abrasives.

It is preferable that they are 5 mass % - 30 mass % with respect to dentifrice composition whole quantity, and, as for total content (total amount including component (E)) of an abrasive, it is more preferable that they are 5 mass % - 20 mass %.

As a caking additive, an organic type caking additive and an inorganic type caking additive are illustrated, The 1 type selected from these may be sufficient, and 2 or more types of combination may be sufficient as it.

Examples of the organic binder include sodium polyacrylate, carrageenan, sodium carboxymethylcellulose, sodium alginate, xanthan gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, propylene glycol alginate, pullulan, gelatin. , hydroxypropyl cellulose, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymer. Examples of the inorganic binder include thickened silicic anhydride and bentnite, and thickened silicic anhydride is preferred. Moreover, it is preferable that it is 1.5 ml/g or more, and, as for the liquid absorption amount of viscous silicic anhydride, it is more preferable that they are 1.5 ml/g - 5 ml/g.

One type may be sufficient as each organic type caking additive and an inorganic substance caking additive, and 2 or more types of combinations may be sufficient as them. It is preferable that a caking additive is a combination of an organic type caking additive and an inorganic type caking additive.

When using an organic type binder, the content is 0.5 mass % - 3 mass % with respect to dentifrice composition whole quantity normally. When using an inorganic binder, it is preferable that the content is 1-10 mass %, It is more preferable that it is 1-7 mass %, It is still more preferable that it is 2-6 mass %. Thereby, a sufficient component (A) stabilizing effect can be acquired and oral dispersibility can be exhibited.

As a viscous agent (wetting agent), For example, Sugar alcohol, such as sorbitol, xylitol, maltitol, and erythritol; and polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, polyethylene glycol and polypropylene glycol. A viscous agent can be used individually by 1 type or in combination of 2 or more type. When using a viscous agent, the total content (summary with a component (C)) can be determined in the range which does not impair the effect of this invention, and is 30-70 mass % normally with respect to dentifrice composition whole quantity.

As surfactant other than component (F), a nonionic surfactant, an amphoteric surfactant, etc. can be used, for example.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene ether of glycerin ester, sucrose fatty acid ester, fatty acid alkylolamide , and glycerin fatty acid esters. Among these, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, fatty acid alkylolamide, sorbitan fatty acid ester and the like are preferably used from the viewpoint of versatility. As for polyoxyethylene alkyl ether, it is preferable that the carbon chain length of an alkyl chain is C12-18. As for polyoxyethylene alkyl ether, it is preferable that the average added mole number of ethylene oxide is 3-30. As for polyoxyethylene hydrogenated castor oil, it is preferable that ethylene oxide average added mole number (average added EO) is 20-100. As for fatty acid alkylolamide, it is preferable that the carbon chain length of an alkyl chain is C12-14. As for sorbitan fatty acid ester, it is preferable that carbon number of a fatty acid is 12-18. As for polyoxyethylene sorbitan fatty acid ester, it is preferable that carbon number of a fatty acid is 16-18. Moreover, as for polyoxyethylene sorbitan fatty acid ester, it is preferable that the average added mole number of ethylene oxide is 10-40.

Examples of the amphoteric surfactant include an alkylbetaine-based surfactant, an amine oxide-based surfactant, and an imidazolinium betaine-based surfactant. Specific examples of the amphoteric surfactant include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and palm oil fatty acid amide alkyl betaine, with palm oil fatty acid amide propyl betaine being preferred.

The surfactant other than (F) may be used individually by 1 type, or 2 or more types of combinations may be sufficient as it. When a dentifrice composition contains surfactant other than (F), it is preferable that the content is 0.01 mass % - 10 mass % with respect to dentifrice composition whole quantity.

Examples of the sweetener include sodium saccharin, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, palatinose (trademark), maltitol, xylitol, and arabitol. Single 1 type may be sufficient as a sweetener, and 2 or more types of combinations may be sufficient as it. When using a sweetener, content can be suitably determined in the range which does not impair the effect of this invention.

Examples of the preservative include paraoxybenzoate esters such as sodium benzoate, methylparaben, ethylparaben, and butylparaben, and benzalkonium chloride. Single 1 type may be sufficient as a preservative, and 2 or more types of combinations may be sufficient as it. When using a preservative, the content can be suitably determined in the range which does not impair the effect of this invention.

As a fragrance|flavor, the usual fragrance|flavor component which can be used for oral preparations can be used individually or as a fragrance|flavor composition which combined two or more. It is preferable that content of a fragrance|flavor is 0.00001 mass % - 3 mass % with respect to dentifrice composition whole quantity.

As a coloring agent, For example, natural pigments, such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, tamarind pigment; Legal pigments such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, riboflavin, sodium copper chloropine, titanium oxide, titanium dioxide, etc. can be heard When a dentifrice composition contains a coloring agent, it is preferable that the content is 0.00001 mass % - 3 mass % with respect to dentifrice composition whole quantity.

Examples of the medicinal component include components other than component (A), ie, the following components: fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, and strontium fluoride; sterilizing or antibacterial agents such as chlorhexidine hydrochloride, triclosan, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; tartar preventive agents such as condensed phosphates such as sodium pyrophosphate and sodium polyphosphate, zeolite, and phosphates such as sodium monohydrogen phosphate and trisodium phosphate; anti-inflammatory agents such as tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetic acid, ε-aminocaproic acid, and yellow white extract; astringents such as sodium chloride; Hypersensitivity inhibitors, such as potassium nitrate, aluminum lactate, and strontium chloride; Vitamins, such as ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, and tocopherol acetate ester, etc. are mentioned. Single 1 type may be sufficient as a medicinal component, and 2 or more types of combinations may be sufficient as it. When using a medicinal ingredient, the content can be suitably set in the pharmaceutically acceptable range with respect to each medicinal ingredient.

It is preferable that the dentifrice composition of this invention mix|blends a disinfectant|microbicide and/or an antibacterial agent among the said medicinal component. Thereby, a skirt composition can exhibit a higher sterilization power. A more preferable disinfectant|microbicide is isopropyl methyl phenol.

Although there is no limitation in particular in the lower limit of content of a disinfectant|microbicide, It is preferable with respect to whole quantity of the dentifrice composition of this invention, and it is preferable that it is 0.01 mass % or more, and it is more preferable that it is 0.02 mass % or more. Thereby, sufficient penetration sterilization force with respect to a biofilm can be acquired.

Although there is no limitation in particular in the upper limit of content of a disinfectant|microbicide, In order to suppress oral mucous membrane irritation, it is preferable that it is 0.3 mass % or less with respect to the whole quantity of the dentifrice composition of this invention, and it is more preferable that it is 0.2 mass % or less.

When the dentifrice composition of this invention contains a disinfectant|microbicide, it is preferable that it is 0.01-0.3 mass %, and, as for content with respect to whole quantity of the dentifrice composition, it is more preferable that it is 0.02-0.2 mass %. 2.5-150 are preferable and, as for the ratio (content of (F) component / content of disinfectant) of content with respect to content with respect to the whole quantity of the dentifrice composition of a disinfectant with respect to the whole quantity of the dentifrice composition of component (F), 2.5-120 This is more preferable.

As a solvent, C3 or less lower alcohols, such as ethanol and a propanol, etc. other than (D) water can be mix|blended, for example. When a dentifrice composition contains a lower alcohol, it is preferable that the content is 1 mass % - 20 mass % with respect to dentifrice composition whole quantity.

As a pH adjuster, well-known acids, alkalis, such as hydrochloric acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium phosphate, sodium dihydrogen phosphate, and a buffer are mentioned, for example. When using a pH adjuster, the content can be suitably determined in the range which does not impair the effect of this invention.

5.0 or more are preferable and, as for pH (20 degreeC) of the dentifrice composition of this invention, 5.4 or more are more preferable. Thereby, demineralization of the teeth can be suppressed. 6.5 or less are preferable and, as for the upper limit of pH, 6.0 or less are more preferable. Thereby, sufficient component (A) stabilizing effect can be acquired.

Example

The present invention will be specifically illustrated by way of examples below, but the present invention is, of course, not limited to these examples. Hereinafter, "%" means "mass %" unless otherwise specified.

[Main raw materials used in Examples and Comparative Examples]

<Component (A)>

Allantoin (manufactured by Pharmachem Asia)

Allantoin chlorhydroxyaluminum (manufactured by Pharmachem Asia, trade name "Arukuroki")

Allantoindihydroxyaluminum (manufactured by Pharmachem Asia, trade name "Arugioki")

<Component (B)>

Citric acid (manufactured by Fuso Chemical Industries, Ltd., trade name “citric acid-hydrate”)

(Comparative example) Phosphoric acid (manufactured by Kanto Chemical Co., Ltd., trade name “Phosphoric Acid”)

<Component (C)>

85% glycerin (manufactured by Lion Chemicals)

<Ingredient (E)>

Silicic anhydride (abrasiveness, liquid absorption 1.0ml/g) (manufactured by Daki Chemical Co., Ltd.)

<Component (F)>

Sodium lauroylmethyltaurine (manufactured by Nikko Chemicals, trade name "NIKKOL LMT")

Sodium lauroyl glutamate (manufactured by Asahi Kasei Chemicals, trade name "Amino Sapacuto (registered trademark) ALMS-P1")

Sodium myristoyl glutamate (manufactured by Asahi Kasei Chemicals, trade name "Amino Sapacuto (registered trademark) AMMS-P1")

<Ingredient (G)>

Sodium sulfate (solubility in purified water at 20°C: 20g/100ml)

Sodium chloride (solubility in purified water at 20°C: 36g/100ml)

<Component (J)>

(J1) Sodium metaphosphate (pH (25°C) of 1% aqueous solution: 1.7 to 3.0, maker name: Taihei Chemical Industry Co., Ltd., trade name 「Ultoraporin」)

(J1) Disodium dihydrogen pyrophosphate (pH (25°C) of 1% aqueous solution: 3.8 to 4.5, maker name: Taihei Chemical Industry Co., Ltd., trade name “sodium acid pyrophosphate”)

(J2): Disodium edetate (Manufacturer name: Akzo Nobel Co., Ltd., trade name "Deizorubin NA2")

<Other ingredients>

Silicic anhydride (thickening, liquid absorption 2.5 ml/g) (DSL Japan, trade name "Capurex")

Isopropylmethylphenol (disinfectant) (Osaka Chemical Co., Ltd., trade name "Isopropylmethylphenol")

70% sorbitol (manufactured by Rocket)

As for the other added ingredients, standard products from Oe Won-gyu were used.

[Examples 1 to 16 and Comparative Examples 1 to 7]

(The preparation method of the dentifrice composition of Examples 1-16 and Comparative Examples 1-7)

Using the above-mentioned component, according to the compounding quantity shown in Tables 1-3, the dentifrice composition of Examples 1-16 and Comparative Examples 1-7 was prepared by the following preparation method. In addition, the compounding quantity of each component shown in Tables 1-3 is the value (AI) converted by the pure part except 85% glycerol. The value (AI) in terms of pure fractions for 85% glycerin is also shown in the table. The unit of each compounding quantity is mass %.

(1) Component (A), component (B), sodium fluoride, sodium saccharin, silicic anhydride (thickening), sodium citrate and component (C) were mixed and dissolved in purified water at room temperature (mixture (X)).

(2) Sodium carboxymethylcellulose and sodium polyacrylate were dispersed in propylene glycol at room temperature (mixture (Y)). Titanium oxide and mixture (Y) were added and mixed in mixture (X) during stirring to prepare mixture (Z).

(3) In the mixture (Z), the fragrance, sodium lauryl sulfate and component (E) were mixed at room temperature using a kneader (manufactured by Miyagawa Shoji), and defoaming was performed under reduced pressure (5.3 kPa) to obtain a skirt composition. .

About the prepared dentifrice composition, according to the following procedure, the allantoin degradation inhibitory effect in an oral cavity, stringiness, and intraoral dispersibility were evaluated. The evaluation results are shown in Tables 1-3.

(Method for evaluating the allantoin degradation inhibitory effect)

Regarding the skirt composition after storage at 50°C for 1 month, the allantoin concentration was measured using HPLC according to the following test conditions. The residual ratio when the allantoin concentration immediately after preparation of each sample was set to 100% was calculated, and the decomposition inhibitory effect of allantoin was judged according to the following criteria.

<Test conditions>

Detector: Ultraviolet Absorption Photometer (Measurement Wavelength: 210nm)

Column: Inertsil NH ₂ (4.6mmφ×250mm)

Column temperature: 35℃

Mobile phase: acetonitrile/phosphate buffer solution (4: 1)

Phosphate buffer solution: 5.75 g of ammonium dihydrogen phosphate was dissolved in 750 ml of water, pH was adjusted to 2.5 by adding phosphoric acid, and then water was added to make 1,000 ml.

<Device used>

Pump : Nippon Spectroscopy Co., Ltd. PU-980

Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X

Detector: Nippon Spectroscopy Co., Ltd. UV-970

Column thermostat: Senshu Science SCC-2100

Flow rate: 1ml/min

<Judgment Criteria>

◎ : 95% or more and 100% or less

○ : 90% or more and less than 95%

× : less than 90%

(Method for evaluating formality)

The pulled height of the thread when the tube mouth is pressed so that it is vertical on the paper, and the skirt composition is ejected by 1 cm in length, and then pulled up vertically, e.g. It was set as a private evaluation, and the following criteria evaluated.

<Judgment Criteria>

◎: The thread height is less than 1.0 cm

○: The thread height is 1.0 cm or more and less than 2.0 cm

△: The height of the yarn is 2.0 cm or more and less than 3.0 cm

×: the height of the thread is 3.0 cm or more

(Method for evaluating dispersibility in the oral cavity)

The following evaluation criteria evaluated the feeling of ten monitors putting the dentifrice composition on the toothbrush, and washing|cleaning the inside of an oral cavity. The average of the evaluation points of 10 persons was classified according to the following criterion.

<Evaluation criteria>

4 points|pieces: The touch of the dentifrice composition disperse|distributed in an oral cavity is felt very much

3 points|pieces: The feeling of the dentifrice composition being disperse|distributed in an oral cavity is felt

2 points|pieces: The feeling of the dentifrice composition disperse|distributing in an oral cavity is slightly felt.

1 point|piece: The feeling of dispersing the dentifrice composition in the oral cavity is not felt.

<Judgment Criteria>

◎: Average score of 3.5 or higher

○: Average point 3.0 or more and less than 3.5

△: average score of 2.0 or more but less than 3.0

×: Average score less than 2.0

[Table 1]

[Table 2]

[Table 3]

Tables 1-3 show the following. The dentifrice compositions of Examples 1 to 16 were excellent in any evaluation of the allantoin decomposition inhibitory effect, stringiness, and dispersibility in the oral cavity. On the other hand, Comparative Examples 1 and 4 in which the content of the component (C) is less than 30% by mass, Comparative Example 5 in which the moisture content exceeds 50% by mass, Comparative Example 6 in which the component (B) is not included, and the component (B) In Comparative Example 7 containing phosphoric acid instead, the allantoin degradation inhibitory effect was inferior. In the comparative example 2 in which content of a component (C) exceeds 60 mass %, and the comparative example 3 whose moisture content is less than 20 mass %, it was inferior to stringiness and oral dispersibility.

These results show that the dentifrice composition of this invention has a component (A) stabilizing effect and is excellent also in usability.

[Examples 2-1 to 2-26]

(Preparation of the dentifrice composition of Examples 2-1 to 2-26)

Using the component mentioned above, according to the compounding quantity shown in Tables 4-7, the dentifrice composition was prepared by a regular method. In addition, the compounding quantity of each component shown in Tables 4-7 is the value (AI) converted by the pure part except 85% glycerol. The value (AI) in terms of pure fractions for 85% glycerin is also shown in the table. The unit of each compounding quantity is mass %.

The following tests were done about the obtained skirt composition.

(1) Evaluation method of decomposition inhibitory effect of allantoin and its derivatives

The concentration of allantoin (a) immediately after each dentifrice composition was prepared and the concentration (b) of allantoin after each dentifrice composition was stored at 50° C. for 1 month were measured by high performance liquid chromatography ( HPLC) was used. Assuming that the allantoin concentration of the dentifrice composition immediately after production is 100%, the allantoin residual ratio of the dentifrice composition after storage at 50° C. for 1 month (((b)/(a))×100 (%)) is calculated and the decomposition inhibitory effect of allantoin and its derivatives was determined according to the following criteria.

<Test conditions>

・Detector: Ultraviolet Absorption Photometer (Measurement Wavelength: 210nm)

·Column: Inertsil NH ₂ (4.6mmφ×250mm) (manufactured by GL Sciences)

·Column temperature: 35℃

Mobile phase: acetonitrile/phosphate buffer solution (4: 1)

Flow rate: 1ml/min

· Phosphate Buffer Solution:

5.75 g of ammonium dihydrogen phosphate was dissolved in 750 ml of water, pH was adjusted to 2.5 by adding phosphoric acid, and then water was added to make 1,000 ml.

<Device used>

·Pump: Nippon Spectroscopy Co., Ltd. PU-980

·Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X

Detector: Nihon Spectroscopy Co., Ltd. UV-970

·Column thermostat: Senshu Science Co., Ltd. SCC-2100

<Judgment Criteria>

◎: Allantoin residual rate is 90% or more and 100% or less

○: Allantoin residual rate is 85% or more and less than 90%

×: Allantoin residual rate is less than 85%

(2) Evaluation method of oral mucosa irritation

The following evaluation criteria evaluated the irritation|stimulation to the oral cavity at the time of putting a dentifrice composition on the toothbrush and washing|cleaning the inside of an oral cavity. The average of the evaluation points of 10 persons was classified according to the following criterion.

<Evaluation criteria>

4 points|pieces: The irritation|stimulation to the oral cavity is not felt.

3 points|pieces: The irritation|stimulation to the oral cavity is slightly sensed.

2 points|pieces: The irritation|stimulation to the oral cavity is sensed.

1 point|piece: The irritation|stimulation to the oral cavity is felt very much.

<Judgment Criteria>

◎ : Average score of 3.5 or higher

○: Average point 3.0 or more and less than 3.5

△: average score of 2.0 or more but less than 3.0

×: Average score less than 2.0

(3) Evaluation method of pogoseong (泡高性)

After dispersing 1 g of the dentifrice composition in 20 ml of purified water, the entire amount was transferred to a 50 ml Nessler-type colorimetric tube, and mixed by shaking 20 times in 10 seconds. After that, it is left still, and the scale of the upper surface of the foam is measured after 5 minutes.

<Judgment Criteria>

◎ : 40ml or more

○: 35ml or more and less than 40ml

×: less than 35ml

(4) Evaluation method of penetrating sterilization power for biofilm

A hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm was treated with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours, and this was treated as a model biofilm production carrier. body) was used. As the culture medium, a solution obtained by dissolving 30 g of trypticase soy broth (manufactured by Difco) in 1 liter of purified water was used in which 5 mg/l of hemin (manufactured by Sigma) and 1 mg/l of vitamin K (manufactured by Wako Pure Chemical Industries, Ltd.) were added. All oral bacteria used for the construction of the model biofilm were purchased from the American Type Culture Collection (ATCC), and Streptococcus gordonii ATCC51656 strain and Actinomyces as oral bacteria common to the oral cavity. Naeslundi (Actinomyces naeslundii) ATCC51655 strain, Porphyromonas gingivalis ATCC33277 strain was used as a pathogenic bacterium. Each of these 3 strains was inoculated into the above-mentioned culture solution so as to become 2×10 ⁷ cfu/ml (colony forming units), and 37° C. with a saliva-treated HA carrier under anaerobic conditions (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) for 2 weeks (the substitution rate of the culture solution was 10 vol%), and a model biofilm of a mixture of three strains was formed on the surface of the HA carrier.

The model biofilm formed was evaluated as an evaluation agent (in the skirt composition, artificial saliva (CaCl ₂ : 2.2 mmol/L, KH ₂ PO ₄ : 2.2 mmol/L, acetic acid: 0.1 mol/L, Clostridium histolyticum-derived collagenase (Type 1A) , Sigma): 1.0 unit/ml, pH 6.5) was added twice by mass, dispersed, immersed in 2 ml of centrifuged supernatant) for 3 minutes, and 6 times with 1 ml of sterile physiological saline washed. Thereafter, the model biofilm is dispersed in sterile physiological saline by ultrasonication (200 μA, 10 seconds) in 4 ml of sterile physiological saline, and 50 μl smeared on a Bacteroides agar plate. Thus, anaerobic culture (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) was performed until colonies could be visually confirmed. The number of grown colonies was counted, the viable cell number (cfu) of the remaining Porphyromonas gingivalis bacteria was calculated|required, and it judged according to the following reference|standard.

<Evaluation criteria>

◎: cfu less than 10 ⁶

○: cfu 10 ⁶ or more and less than 10 ⁷

×: cfu is 10 ⁷ or more

The formulation of the dentifrice composition (Examples 2-1 to 2-26) and the evaluation result are shown in Tables 4 to 7 below.

[Table 4]

[Table 5]

[Table 6]

[Table 7]

According to the compositions shown in Tables 4 to 7, the decomposition of allantoin and its derivatives was suppressed, and the foaming property was excellent, and the irritation to the oral mucosa was reduced.

[Example 3-1 to 3-3]

[Recipe]

The dentifrice composition (example and blank formulation) of the composition (mass %) shown in Table 8 was prepared by the following method, it filled in the container (aluminum-laminated tube), and the following method evaluated it. The results are shown in Table 8.

<Preparation method>

(1) A water-soluble component and a viscosity modifier were mixed and dissolved in purified water at room temperature (mixture (X)).

(2) The binder was dispersed in propylene glycol at room temperature (mixture (Y)), and the mixture (Y) was added and mixed in the mixture (X) being stirred to prepare a mixture (Z).

(3) In mixture (Z), fragrance|flavor, anionic surfactant, and abrasive|polishing agent were mixed at normal temperature using a kneader, defoaming by reduced pressure (5.3 kPa) was performed, and the dentifrice composition was obtained.

[Test method]

(1) Retention and absorption test method of water-soluble active ingredient

<Experiment method>

The skin of a 7-week-old male hairless mouse cut into 1.5 cm squares (Nippon S.E. Co., Ltd.; Lavoskin) was placed on a 6-well plate, 5 ml of artificial saliva was added, and left for 2 hours. did Place a glass frame on the skin so that the penetration area (about 0.8 cm2) is constant, and inject 300 μl of a solution diluted 3 times with artificial saliva of the oral compositions of the examples or comparative examples shown in the table below. , and left still for 5 minutes. Thereafter, the diluted solution was discarded, 5 ml of water was added, and the mixture was washed at 160 rpm for 1 minute using a shaker. The above washing was repeated and performed twice in total.

The washing liquid was discarded, the skin was collected in a tube, 1 ml of EtOH (90%) was added, and extraction was performed for 5 minutes with a vortex mixer. The extract was collected, and after equal-fold dilution with purified water, tranexamic acid was quantified by HPLC.

Allantoin was quantified using HPLC according to the following test conditions. The retention and absorption rates when the retention and absorption rates of allantoin in the blank formulation were set to 100% were calculated, and the retention and absorption effects of allantoin were determined according to the following criteria.

(device used)

·Pump: Nippon Spectroscopy Co., Ltd. PU-980

·Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X

Detector: Nihon Spectroscopy Co., Ltd. UV-970

·Column thermostat: Senshu Science Co., Ltd. SCC-2100

·Eluent flow rate: 1ml/min

(Exam conditions)

HPLC conditions for quantifying allantoin are as follows.

・Detector: Ultraviolet Absorption Photometer (Measurement Wavelength: 210nm)

·Column: Inertsil NH ₂ (4.6mmφ×250mm)

·Column temperature: 35℃

·Eluent: acetonitrile/phosphate buffer solution (4:1)

(A phosphate buffer solution was prepared by dissolving 5.75 g of ammonium dihydrogen phosphate in 750 ml of water, adjusting the pH to 2.5 by adding phosphoric acid, and adding water to make 1000 ml.)

・Injection amount: 5 μl

(Criteria for judgment in the table below)

◎◎ : 200% or more

◎ : 175% or more and less than 200%

○∼◎ : 150% or more and less than 175%

○ : 125% or more and less than 150%

△: 100% or more and less than 125%

× : less than 100%

(2) Usability evaluation method

The following evaluation criteria evaluated the usability|use_condition (odor and taste) when ten monitors put the composition for oral cavity on a toothbrush, and wash|cleaned the inside of an oral cavity. The average of the evaluation points of 10 persons was classified according to the following criterion.

(Smell evaluation criteria)

4 points|pieces: No odor is felt in the oral cavity.

3 points|pieces: The odor is slightly unpleasant in an oral cavity.

2 points|pieces: An odor is felt unpleasantly in an oral cavity.

1 point|piece: In oral cavity, odor is felt very unpleasantly.

(Standards for odor determination in the table below)

◎ : Average score of 3.5 or higher

○: Average point 3.0 or more and less than 3.5

△: average score of 2.0 or more but less than 3.0

×: Average score less than 2.0

(Taste evaluation criteria)

4 points|pieces: No irritation is felt in the oral cavity.

3 points|pieces: In the oral cavity, slight burning sensation is felt.

2 points|pieces: An image is felt in the oral cavity.

1 point|piece: In the oral cavity, it is very sensitive.

(Taste criteria in the table below)

◎ : Average score of 3.5 or higher

○: Average point 3.0 or more and less than 3.5

△: average score of 2.0 or more but less than 3.0

×: Average score less than 2.0

[Table 8]

A prescription example is shown below.

[Table 9]

[Table 10]

[Formulation 3-11] dentifrice

Pyridoxine Hydrochloride 0.2

Citric acid 0.7

85% Glycerin 50

Isopropylmethylphenol 0.1

Sodium lauroyl sarcosine 0.2

Sodium citrate 0.6

Sodium Lauryl Sulfate 1.0

Ferry 1.2

Polyoxyethylene (20) hydrogenated castor oil 1.2

isostearic acid 0.3

Phytosteryl isostearate 0.3

Silicic anhydride (abrasive) 10

Silicic anhydride (thickening) 5

Sodium polyacrylate 0.5

xanthan gum 0.9

Sodium saccharin 0.2

Propylene Glycol 3.0

Methyl paraoxybenzoate 0.05

Butyl paraoxybenzoate 0.01

Titanium Oxide 0.1

Sodium Fluoride 0.21

water rest

Total 100.0% by mass

[Formulation 3-12] dentifrice

Dipotassium glycyrrhizinate 0.2

85% Glycerin 50

Isopropylmethylphenol 0.1

Sodium lauroyl sarcosine 0.2

Sodium Lauryl Sulfate 1.0

Ferry 1.2

Polyoxyethylene (20) hydrogenated castor oil 1.2

isostearic acid 0.3

Polyricinoleate hexaglyceryl 0.3

Silicic anhydride (abrasive) 10

Silicic anhydride (thickening) 5

Sodium polyacrylate 0.5

xanthan gum 0.9

Sodium saccharin 0.2

Propylene Glycol 3.0

Methyl paraoxybenzoate 0.05

Butyl paraoxybenzoate 0.01

Titanium oxide 0.1

Sodium Fluoride 0.21

water rest

Total 100.0% by mass

[Example 4-1 to 4-18]

(Preparation of the skirt composition of Examples 4-1 to 4-18)

Using the above-mentioned component, according to the compounding quantity shown in Tables 11-14, the skirt composition (plain skirt) was prepared by the following preparation method. In addition, the compounding quantity of each component shown in Tables 11-14 is the value (AI) converted into pure parts except 85% glycerol and 70% sorbitol liquid. The values (AI) in terms of pure parts for 85% glycerin and 70% sorbitol are also shown in the table. The unit of each compounding quantity is mass %.

[Method for preparing skirt composition]

(1) Dissolve component (A), component (F), component (G), sodium fluoride, sodium saccharin, citric acid, sodium citrate in purified water, and add silicic anhydride (thickening property) and component (C) at room temperature and mixed (Mixture (X)).

(2) Sodium carboxymethylcellulose and sodium polyacrylate were dispersed in propylene glycol at room temperature (mixture (Y)). Titanium oxide and mixture (Y) were added and mixed in mixture (X) during stirring to prepare mixture (Z).

(3) In the mixture (Z), perfume and silicic anhydride (abrasive properties) were mixed at room temperature using a kneader (manufactured by Miyagawa Shoji), and defoaming was performed under reduced pressure (5.3 kPa) to obtain a skirt composition.

The measurement of pH was performed using the pH meter (Metora Toledo Co., Ltd. Seven Easy).

The following tests were done about the obtained skirt composition.

(1) Evaluation method of decomposition inhibitory effect of allantoin and its derivatives

About the skirt composition after storage at 60 degreeC for 1 week, the allantoin concentration was measured using high performance liquid chromatography (HPLC) according to the following test conditions. The residual ratio when the allantoin concentration immediately after preparation of each dentifrice composition was set to 100% was calculated, and the decomposition inhibitory effect of allantoin was judged according to the following criteria.

<Test conditions>

・Detector: Ultraviolet Absorption Photometer (Measurement Wavelength: 210nm)

·Column: Inertsil NH ₂ (4.6mmφ×250mm) (manufactured by GL Sciences)

·Column temperature: 35℃

Mobile phase: acetonitrile/phosphate buffer solution (4: 1)

Flow rate: 1ml/min

·Phosphate Buffer Solution:

5.75 g of ammonium dihydrogen phosphate was dissolved in 750 ml of water, pH was adjusted to 2.5 by adding phosphoric acid, and then water was added to make 1,000 ml.

<Device used>

·Pump: Nippon Spectroscopy Co., Ltd. PU-980

·Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X

Detector: Nihon Spectroscopy Co., Ltd. UV-970

·Column thermostat: Senshu Science Co., Ltd. SCC-2100

<Judgment Criteria>

◎: Allantoin residual rate is 95% or more and 100% or less

○: Allantoin residual rate is 90% or more and less than 95%

×: Allantoin residual rate is less than 90%

(2) Appearance stability evaluation method

The dentifrice composition was filled in a tube, and the following reference|standard evaluated the external appearance of the dentifrice composition at the time of taking off the cap after storage at 30 degreeC for 6 months. Of the three tubes evaluated, it was judged as the worst sample evaluation.

<Evaluation criteria>

◎: No change in appearance is recognized

○: Almost no change in appearance is recognized

x: There is a clear precipitate, and an external appearance is inferior.

(3) Evaluation method of irritation to oral mucosa

The following evaluation criteria evaluated the irritation|stimulation in the oral cavity at the time of 4 monitor immersing the dentifrice composition on the toothbrush and washing|cleaning the oral cavity. The average of the four evaluation points was classified according to the following criterion.

<Evaluation criteria>

4 points|pieces: No irritation|stimulation is felt in the oral cavity.

3 points: slight irritation in the oral cavity

2 points|pieces: irritation|stimulation is felt in the oral cavity

1 point: I feel the irritation very much in the oral cavity

<Judgment Criteria>

◎ : Average score of 3.5 or higher

○: Average score of 2.5 or more and less than 3.5

△: average point less than 2.0 to 2.5

×: Average score less than 2.0

The blending and evaluation results of the dentifrice composition (Examples 4-1 to 4-18) are shown in Tables 11 to 14 below.

[Table 11]

[Table 12]

[Table 13]

[Table 14]

(Footnotes in Tables 11 to 14)

* : Shows the value converted to pure fraction.

According to the compositions shown in Tables 11 to 14, the decomposition of allantoin and its derivatives was suppressed, and at the same time, it was excellent in appearance stability, and the irritation was suppressed, so that the usability was good.

A formulation example of the dentifrice composition of the present invention is shown below.

[Formulation 4-1] dentifrice

Allantoin 0.1

Sodium Lauryl Sulfate 1.4

Sodium Chloride 12

85% Glycerin 25

70% sorbit solution 20

Citric acid 0.5

Sodium citrate 0.5

Isopropylmethylphenol 0.05

Cetylpyridinium Chloride 0.05

Triclosan 0.02

Sodium Fluoride 0.21

tranexamic acid 0.05

Dipotassium glycyrrhizinate 0.2

Polyoxyethylene (20) hydrogenated castor oil 1.6

Propylene glycol 3

Carboxymethylcellulose sodium 1

Sodium polyacrylate 0.5

Propylene glycol alginate 0.1

Polyethylene glycol 4000 0.4

Sodium saccharin 0.18

Silicic anhydride (thickening) 5

Titanium Oxide 0.1

Ferry 1.28

Silicic anhydride (abrasive) 10

isostearic acid 0.3

Phytosteryl isostearate 0.3

water rest

Total 100% by mass

[Prescription 4-2] dentifrice

Allantoin 0.1

Sodium myristoyl glutamate 1

Sodium sulfate 0.5

85% Glycerin 40

Citric acid 0.7

Sodium citrate 0.5

Isopropylmethylphenol 0.05

Cetylpyridinium Chloride 0.05

Triclosan 0.02

Sodium Fluoride 0.21

β-glycyrrhetinic acid 0.2

ε-aminocaproic acid 0.2

Polyoxyethylene (20) hydrogenated castor oil 0.8

Polyoxyethylene (5) stearyl ether 0.8

Coconut oil fatty acid amide propyl betaine 1

Propylene glycol 3

Xanthan Gum 1.5

Sodium Alginate 0.5

Propylene glycol alginate 0.1

Polyethylene glycol 4000 0.4

Sodium saccharin 0.18

Silicic anhydride (thickening) 5

Titanium oxide 0.1

Ferry 1.28

Calcium hydrogen phosphate 10

isostearic acid 0.5

Phytosteryl isostearate 0.5

water rest

Total 100% by mass

[Formulation 4-3] dentifrice

Allantoin 0.1

Sodium lauroylmethyltaurine 1.2

sodium sulfate 0.5

85% glycerin 50

Citric acid 0.7

Sodium citrate 0.5

Isopropylmethylphenol 0.05

Cetylpyridinium Chloride 0.05

Triclosan 0.02

Sodium Fluoride 0.21

tranexamic acid 0.05

Polyoxyethylene (20) hydrogenated castor oil 1.6

Propylene glycol 3

Sodium Carboxymethylcellulose 1.2

Sodium polyacrylate 0.6

Propylene glycol alginate 0.1

Polyethylene glycol 4000 0.4

Sodium saccharin 0.18

Silicic anhydride (thickening) 5

Titanium oxide 0.1

Ferry 1.28

Silicic anhydride (abrasive) 10

Isostearic acid 0.1

Phytosteryl isostearate 0.1

water rest

Total 100% by mass

[Formulation 4-4] dentifrice

Allantoin 0.1

Sodium lauroylmethyltaurine 0.6

Sodium Lauryl Sulfate 0.6

sodium chloride 0.5

85% Glycerin 25

70% Sorbit Solution 25

Citric acid 0.7

Sodium citrate 0.5

Isopropylmethylphenol 0.05

Cetylpyridinium Chloride 0.05

Triclosan 0.02

Sodium Fluoride 0.21

β-glycyrrhetinic acid 0.2

ε-aminocaproic acid 0.2

Polyoxyethylene (20) hydrogenated castor oil 1.6

Propylene glycol 3

Carboxymethylcellulose sodium 1

Sodium polyacrylate 0.6

Sodium Alginate 0.5

Propylene glycol alginate 0.1

Polyethylene glycol 4000 0.4

Sodium saccharin 0.18

Silicic anhydride (thickening) 5

Titanium oxide 0.1

Ferry 1.28

Silicic anhydride (Abrasiveness) 15

Isostearic acid 0.1

Phytosteryl isostearate 0.1

water rest

Total 100% by mass

[Examples 5-1 to 5-11]

(Preparation of the skirt composition of Examples 5-1 to 5-11]

Using the above-mentioned component, according to the compounding quantity shown in Tables 15-17, the skirt composition (plain skirt) was prepared by the following preparation method. In addition, the compounding quantity of each component shown in Table 18 - Table 21 is the value (AI) converted into pure parts except 85% glycerol and 70% sorbitol. The values (AI) in terms of pure parts for 85% glycerin and 70% sorbitol are also shown in the table. The unit of each compounding quantity is mass %.

(Method for preparing skirt composition)

The skirt composition of the composition (mass %) shown in Tables 15-17 was prepared by the following method, it filled in the container (aluminum-laminated tube), and the following method evaluated it. The results are shown in Tables 15 to 17.

<Preparation method>

(1) A water-soluble component and a viscosity modifier were mixed and dissolved in purified water at room temperature (mixture (X)).

(2) The binder was dispersed in propylene glycol at room temperature (mixture (Y)), and the mixture (Y) was added and mixed in the mixture (X) being stirred to prepare a mixture (Z).

(3) In mixture (Z), fragrance|flavor, anionic surfactant, and abrasive|polishing agent were mixed at normal temperature using a kneader, defoaming by reduced pressure (5.3 kPa) was performed, and the dentifrice composition was obtained.

About the prepared skirt composition, the allantoin degradation inhibitory effect, the stain removal effect, and usability were evaluated according to the following procedure. The evaluation results are shown in Tables 15 to 17.

(1) Evaluation method of allantoin degradation inhibitory effect

Regarding the skirt composition after storage at 50°C for 2 weeks, the concentration of allantoin was measured using HPLC according to the following test conditions. The residual ratio when the allantoin concentration immediately after preparation of each sample was set to 100% was calculated, and the decomposition inhibitory effect of allantoin was determined according to the following criteria.

<Test conditions>

Detector: Ultraviolet Absorption Photometer (Measurement Wavelength: 210nm)

Column: Inertsil (registered trademark) NH ₂ (4.6 mmφ×250 mm)

Column temperature: 35℃

Mobile phase: acetonitrile/phosphate buffer solution (4:1)

Phosphate Buffer Solution:

5.75 g of ammonium dihydrogen phosphate was dissolved in 750 ml of water, pH was adjusted to 2.5 by adding phosphoric acid, and then water was added to make 1,000 ml.

<Device used>

Pump : Nippon Spectroscopy Co., Ltd. PU-980

Sample introduction part: Kyowa Precision Co., Ltd. KSP-100X

Detector: Nippon Spectroscopy Co., Ltd. UV-970

Column thermostat: Senshu Science SCC-2100

Flow rate: 1ml/min

<Judgment Criteria>

◎ : 95% or more and 100% or less

○ : 90% or more and less than 95%

× : less than 90%

(2) Evaluation method of stain removal effect

A hydroxyapatite plate (HOYA Co., Ltd., φ7.0 mm × 3.5 mm, hereinafter referred to as HAP plate) whose surface was previously sandblasted was mixed with 0.5% albumin aqueous solution, tannin solution and 0.56% ferric (III) citrate. It was immersed in each solution of the aqueous solution at room temperature for 30 minutes in sequence. This operation was repeated 8 to 9 times per day, and continued until the stain sufficiently adhered to the HAP plate.

For the tannin solution, 50 g of Japanese tea (species: cypress) and 5 black tea tea bags (Lipton, Brisk tea bags) are extracted with hot water, and after cooling, 12 g of powdered coffee (Nescafe) is added, and purified water It was obtained by adjusting to 1200 ml.

The degree of adhesion of the stain to the HAP plate was determined from the L* value measured using a spectrophotometer (Nippon Denko Co., Ltd., SE-2000). The L* value of the HAP plate before the treatment was set as the initial value, and the L* value after the treatment was set as the blank value.

Next, the stained HAP plate is immersed in a dentifrice solution 3 times diluted with artificial saliva (50mM KCl, 1mM CaCl ₂ , 0.1mM MgCl ₂ , 1mM KH ₂ PO ₄ , pH 7.0) at 37° C. for 2.5 minutes, followed by a flat plate grinder was used for brushing in the same test solution. The brushing process was performed 100 times. It washed with water after brushing, the L* value was measured, and the stain removal effect was evaluated.

<Evaluation criteria for stain removal effect>

◎: 50% or more of stain removal

○: Stain removal rate of 40% or more and less than 50%

△: A stain removal rate of 30% or more and less than 40%

×: The stain removal rate is less than 30%

(3) Evaluation method of usability

The following evaluation criteria evaluated the feeling of use (beauty and irritation) at the time of ten monitors applying the dentifrice composition to the toothbrush and washing|cleaning the oral cavity. The average of the evaluation points of 10 persons was classified according to the following criterion.

<Unevaluated criteria>

4 points: No irritation in the oral cavity

3 points: Slight sensation in the oral cavity

2 points: I feel already in the oral cavity.

1 point: I feel very already in the oral cavity.

<Non-judgment criteria>

◎: Average score of 3.5 or higher

○: Average point 3.0 or more and less than 3.5

△: average score of 2.0 or more but less than 3.0

×: Average score less than 2.0

<Oral irritation evaluation criteria>

4 points|pieces: No irritation|stimulation is felt in the oral cavity.

3 points: slight irritation in the oral cavity

2 points|pieces: irritation|stimulation is felt in the oral cavity

1 point: Very irritation is felt in the oral cavity.

<Criteria for Oral Irritation Judgment>

◎ : Average score of 3.0 or higher

○: Average score of 2.5 or more but less than 3.0

△: Average score of 1.5 or more and less than 2.5

×: Average point less than 1.5 points

[Table 15]

[Table 16]

[Table 17]

(Footnotes in Table 15 to Table 17)

* : Shows the value converted to pure fraction.

The compositions shown in Tables 15 to 17 had a component (A) stabilizing effect, and were also excellent in the stain removal effect and usability.

Claims (13)

Component (A): one or more selected from the group consisting of allantoin, allantoin chlorhydroxyaluminum and allantoin dihydroxyaluminum;
Component (B): one or more organic acids selected from the group consisting of citric acid, malic acid, tartaric acid, and phytic acid;
Ingredient (C): glycerin and
Component (D): Contains moisture,
Content of component (C) with respect to whole quantity of dentifrice composition is 34 mass % - 60 mass %, and content of component (D) is 20 mass % - 50 mass %, The dentifrice composition characterized by the above-mentioned. The method of claim 1,
The content of the component (B) with respect to the total amount of the dentifrice composition is 0.3 mass % - 3 mass %, The dentifrice composition characterized by the above-mentioned. 3. The method of claim 1 or 2,
The ratio of content of component (B) with respect to content of component (A) is 2-30, The skirt composition characterized by the above-mentioned. 3. The method of claim 1 or 2,
The ratio of content of component (C) with respect to content of component (A) is 100-5000, The skirt composition characterized by the above-mentioned. 3. The method of claim 1 or 2,
The content of the component (A) with respect to the whole amount of the dentifrice composition is 0.03 mass % - 0.5 mass %, The dentifrice composition characterized by the above-mentioned. The method of claim 1,
Component (E): A skirt composition further comprising one or more abrasives selected from the group consisting of silicic anhydride and calcium hydrogen phosphate. 7. The method of claim 6,
The content of the component (E) with respect to the whole quantity of the dentifrice composition is 5 mass % - 30 mass %, The dentifrice composition characterized by the above-mentioned. 3. The method of claim 1 or 2,
pH in 20 degreeC is 5.0-6.5, The skirt composition characterized by the above-mentioned. The method of claim 1,
A skirt composition further comprising an anionic surfactant. 10. The method of claim 9,
A skirt composition characterized in that the anionic surfactant contains at least one selected from acylamino acids, acyltaurines and salts thereof. 10. The method of claim 9,
A skirt composition, characterized in that it further contains a water-soluble inorganic salt having a solubility in purified water at 20°C of 10 g/100 ml to 500 g/100 ml. The method of claim 1,
A fatty acid having a branched chain structure having 8 to 22 carbon atoms, a fatty acid ester having a linear or branched chain structure having 8 to 22 carbon atoms, and a polyglycerol fatty acid ester represented by the following formula (1):
RO-(C ₃ H ₆ O ₂ R) _n R (1)
[In formula (1), R represents a C5-C25 branched alkyl group or alkenyl group which may have a hydroxyl group. n represents the average degree of polymerization of glycerin, and is 1 to 20.]
A skirt composition further comprising at least one selected from the group consisting of The method of claim 1,
One or two or more chelating agents selected from the group consisting of the following (J1) to (J2):
(J1): Condensed phosphoric acid and its salt having a pH of 1 to 5 in a 1% aqueous solution at 25°C;
(J2): A skirt composition characterized by further comprising edetic acid and a salt thereof.