JP6125859B2 - Composition for external use - Google Patents

Description

  The present invention relates to a composition for external use that significantly improves the temporal stability of guaiazulene or guaiazulene sulfonates. More specifically, the present invention relates to an external composition comprising one or more selected from the group consisting of guaiazulene or guaiazulene sulfonates, a nonionic surfactant and a betaine acetate type surfactant.

  Azulene compounds such as guaiazulene and guaiazulene sulfonates have anti-inflammatory activity, epithelial tissue repairing action, and the like, and thus are used in compositions for external use. These oral compositions are aqueous compositions having water as a continuous phase for reasons such as a feeling of use, but these azulene compounds are unstable in aqueous solutions due to factors such as heat, light, and air exposure, When blended with an external composition, it has the problem of decomposing and decreasing over time. In particular, an azulene compound exhibits a blue to blue-violet color when mixed with an aqueous compound, so the appearance of the composition is often characterized, but since it fades over time, the appearance of the composition is greatly impaired and the anti-inflammatory effect is reduced. As well as the problem of greatly detracting from the aesthetic value of the product.

  Many solutions have been proposed for these problems. For example, a technique for improving light stability by blending a coloring substance (Patent Document 1), tocopherol acetate (Patent Document 2), bicarbonate and alcohol, organic acid and amino acid, dibutylhydroxytoluene and thiosulfate And nonionic surfactant, technology to improve stability by using berberine and polyvinylpyrrolidone and / or chondroitin in combination (Patent Document 3-6), degassing after container filling and replacing with inert gas Technology to improve the stability (Patent Document 7), Technology to improve the stability by blending nonionic surfactant, gelatin, water-soluble polymer and glycerin and emulsifying in petroleum hydrocarbon (Patent document 8) etc. are mentioned. However, these techniques are insufficient in effect, use compounds that cannot be used in the general composition, or have problems in palatability in oral compositions because of poor taste. Therefore, a sufficiently satisfactory effect cannot be obtained, and the problems have not been solved yet.

Japanese Patent Laid-Open No. 2005-2048 JP 2010-235508 A JP-A-63-51341 JP-A-2005-298542 JP 2004-196671 A JP 2005-298364 A JP-A-10-130141 JP-A-7-89850

  The present invention provides a composition for external use in which a nonionic surfactant and a betaine acetate type surfactant are blended with an azulene compound such as guaiazulene or guaiazulene sulfonate to significantly improve the temporal stability of the azulene compound.

  As a result of intensive studies in view of such circumstances, the present inventors have surprisingly found that at least one azulene compound selected from the group consisting of guaiazulene and guaiazulene sulfonate, alkylglycoside, polyoxyethylene hydrogenated castor oil, and It has been found that by adding one or more nonionic surfactants selected from the group consisting of sorbitan esters and betaine acetate type surfactants, an external composition can be obtained in which the temporal stability of the azulene compound is remarkably improved. The present invention has been completed.

That is, this invention provides the composition for external use of the following items 1-6 especially.
Item 1.
One or more azulene compounds selected from the group consisting of guaiazulene and guaiazulene sulfonates, and one or more nonionic surfactants (A) selected from the group consisting of alkylglycosides, polyoxyethylene hydrogenated castor oil and sorbitan esters, and An external composition comprising a betaine acetate type surfactant (B).
Item 2.
The blending amount of the nonionic surfactant (A) is 0.1 to 4.5% by mass, and the blending amount of the betaine acetate type surfactant (B) is 0.01 to 2% by mass. Item 2. A composition for external use according to Item 1.
Item 3.
Item 1 or 2, wherein the total amount of the nonionic surfactant (A) and the betaine acetate surfactant (B) is 0.5 to 4.0% by mass or less. The composition for external use according to Item.
Item 4.
Item 4. The composition for external use according to Item 3, wherein the total amount of the nonionic surfactant (A) and the betaine acetate surfactant (B) is 0.5 to 2.5% by mass.
Item 5.
Alkyl sulfate ester salt, polyoxyethylene alkyl ether sulfate ester salt, α-olefin sulfonate, fatty acid soap, polyoxyethylene alkyl ether carboxylate salt, alkyl phosphate ester salt, polyoxyethylene alkyl ether phosphate ester salt, N- Item 5. The external composition according to any one of Items 1 to 4, which does not contain an anionic surfactant selected from acylamino acid salts, alkylsulfosuccinates, and polyoxyethylene alkyl ether sulfosuccinates.
Item 6.
Item 6. The external composition according to Items 1 to 5, wherein the external composition is an oral composition.

  The composition for external use of the present invention can obtain excellent temporal stability of azulene compounds such as guaiazulene and guaiazulene sulfonate.

  The composition for a according to the present invention is one or more selected from the group consisting of one or more azulene compounds selected from the group consisting of guaiazulene and guaiazulene sulfonate, and alkylglycoside, polyoxyethylene hydrogenated castor oil and sorbitan ester. The nonionic surfactant (A) and the betaine acetate type surfactant (B) are blended.

  The azulene compound used in the present invention is a general term for compounds having an azulene skeleton in the molecule, and one or more selected from the group consisting of guaiazulene (1,4-dimethyl-7-isopropylazulene) and guaiazulene sulfonate. Can be combined. In the present invention, not only the synthesized compounds but also those extracted from chamomile, yarrow, mugwort, eucalyptus and the like can be used. The azulene compound can be added to the external composition of the present invention in an amount of 0.001 to 1% by mass, and preferably 0.01 to 0.5% by mass.

  The nonionic surfactant (A) used in the present invention is an alkyl glycoside, polyoxyethylene hydrogenated castor oil, and sorbitan ester, and one or a combination of two or more of these can be blended. Specific examples of the alkyl glycoside include alkyl (carbon number 8-10) glycoside, alkyl (carbon number 8-16) glycoside, alkyl (carbon number 12-16) glycoside, lauryl glycoside, cetostearyl glycoside and the like. . As polyoxyethylene hydrogenated castor oil, an average added mole number of ethylene oxide of 5 to 100 can be blended. Among these, the average added mole number is preferably 30 to 100, more preferably 40 to 80, and most preferably 60. As the sorbitan ester, sorbitan fatty acid ester and polyoxysorbitan fatty acid ester can be blended. Specifically, sorbitan monolaurate, sorbitan monostearate, sorbitan monooleate, sorbitan isostearate, polyoxyethylene monopalmitate (20) Examples include sorbitan, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (6) sorbitan monooleate, polyoxyethylene (20) sorbitan trioleate, and the like. These nonionic surfactants have an effect of suppressing a change in the appearance of the composition over time, and among these, when alkyl glucoside is added in an amount of 0.5% by mass or more, the stability of the azulene compound is slightly deteriorated. Although tending, polyoxyethylene hydrogenated castor oil does not affect the stability of the azulene compound, so it can be said that polyoxyethylene hydrogenated castor oil is the most preferred nonionic surfactant. These nonionic surfactants can be added to the external composition of the present invention in an amount of 0.1 to 4.5% by mass, preferably 0.4 to 3.0% by mass.

  The betaine acetate type surfactant (B) used in the present invention refers to an alkyl betaine type surfactant and a fatty acid amidopropyl betaine type surfactant, and one or a combination of two or more of these can be blended. Specific examples of the alkylbetaine surfactant include coconut oil alkyldimethylaminoacetic acid betaine, palm kernel oil alkyldimethylaminoacetic acid betaine, lauryldimethylaminoacetic acid betaine, myristyldimethylaminoacetic acid betaine, palmityldimethylaminoacetic acid betaine, stearyl. Examples include dimethylaminoacetic acid betaine and oleyldimethylaminoacetic acid betaine. Specific examples of fatty acid amidopropyl betaine type surfactants include palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, palm kernel oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauric acid amidopropyldimethylaminoacetic acid betaine, myristic acid amide. Examples thereof include propyldimethylaminoacetic acid betaine, palmitic acid amidopropyldimethylaminoacetic acid betaine, stearic acid amidopropyldimethylaminoacetic acid betaine, and oleic acid amidopropyldimethylaminoacetic acid betaine. These betaine acetate type surfactants can be blended in the external composition of the present invention in an amount of 0.01 to 2% by mass, preferably 0.1 to 1.5% by mass, and 0.3 to 1. It is most preferable to add 0% by mass.

  In the composition for external use of the present invention, the total amount of both the nonionic surfactant (A) and the betaine acetate surfactant (B) is 0.5 to 4.0% by mass. In this case, the color tone peculiar to the azulene compound can be maintained, and it is preferably 2.5% by mass or less. If it exceeds 2.5% by mass, the surfactant may feel irritation and bitterness, which is not preferable.

  In the composition for external use of the present invention, when an anionic surfactant is contained, the color peculiar to the azulene compound is likely to fade over time. Therefore, it is preferable not to contain an anionic surfactant. The anionic surfactant here is alkyl sulfate ester salt, polyoxyethylene alkyl ether sulfate ester salt, α-olefin sulfonate, fatty acid soap, polyoxyethylene alkyl ether carboxylate, alkyl phosphate ester salt, It means a general term for polyoxyethylene alkyl ether phosphate ester salts, N-acyl amino acid salts, alkyl sulfosuccinates, and polyoxyethylene alkyl ether sulfosuccinates. Further, “containing an anionic surfactant” specifically means containing 0.5% by mass or more. That is, “does not contain an anionic surfactant” means “the total amount of the anionic surfactant is less than 0.5% by mass”, most preferably “an anionic interface” It does not contain an active agent. “No anionic surfactant” means “no intentionally containing an anionic surfactant”, and a small amount of anionic surfactant that is mixed in from other raw materials. The presence of means that it is acceptable since it does not affect the color change of the azulene compound.

  The composition for external use of the present invention is one or more nonionic ions selected from the group consisting of one or more azulene compounds selected from the group consisting of guaiazulene and guaiazulene sulfonate, and alkylglycosides, polyoxyethylene hydrogenated castor oil and sorbitan esters. In addition to the surfactant (A) and the betaine acetate surfactant (B), components that can be usually blended in the composition for external use may be further blended as long as the effects of the present invention are not impaired.

  As the surfactant, nonionic surfactants other than alkyl glycosides, polyoxyethylene hydrogenated castor oil and sorbitan esters, amphoteric surfactants other than betaine acetate surfactants, and the like can be blended. Specifically, as the nonionic surfactant, fatty acid alkanolamide, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene block A copolymer etc. are mentioned. Examples of the amphoteric surfactant include 2-undecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-coconut oil fatty acid acyl-N-carboxylmethyl-N-hydroxyethylethylenediamine sodium, and the like. Examples of the cationic surfactant include monoalkyltrimethylammonium salt, dialkyldimethylammonium salt, cetylpyridinium chloride and the like. These surfactants can be used singly or in combination of two or more.

  As abrasives, abrasive silica, calcium hydrogen phosphate, calcium phosphate, tertiary calcium phosphate, tertiary magnesium phosphate, calcium pyrophosphate, hydroxyapatite, insoluble sodium metaphosphate, aluminum silicate, zirconium silicate, calcium silicate, carbonic acid Examples include calcium, magnesium carbonate, alumina, aluminum hydroxide, calcium sulfate, polymethyl methacrylate, pumice, bentonite, and synthetic resin. These binders can be used alone or in combination of two or more.

  As a binder, carboxymethylcellulose sodium, carboxymethylethylcellulose salt, cellulose derivatives such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, microbially produced polymers such as xanthan gum, gellan gum, tragacanth gum, caraya gum, arabiya gum, carrageenan, dextrin, Natural polymers such as agar or natural rubbers, synthetic polymers such as polyvinyl alcohol and polyvinyl pyrrolidone, inorganic binders such as thickening silica and bee gum, O- [2-hydroxy-3- (trimethylammonio) propyl chloride ] Cationic binders such as hydroxyethyl cellulose. These binders can be used alone or in combination of two or more.

  As a flavoring agent, menthol, carvone, methyl salicylate, vanillin, benzyl succinate, methyl eugenol, anethole, limonene, ocimene, n-decyl alcohol, methyl acetate, citronenyl acetate, cineol, ethyl linalool, vanillin, thyme, Nutmeg, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, tea tree oil, tabana oil, star anise Examples include oil, fennel oil, diatom oil, and basil oil. These fragrance | flavors can be used 1 type or in combination of 2 or more types.

  Sweeteners include saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, saumatine, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, maltitol , Xylitol, lactitol and the like. These sweeteners can be used alone or in combination of two or more.

  Examples of the wetting agent and hydrotrope include ethanol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, isoprene glycol, glycerin, diglycerin, sorbit, and polyethylene glycol. These can be used alone or in combination of two or more.

  Examples of the viscosity modifier include hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, crystalline cellulose, carboxyvinyl polymer, polyacrylate, guar gum, xanthan gum, bentonite and hectorite. These can be used alone or in combination of two or more.

  Examples of the conditioning agent include silicone derivatives, cation-modified water-soluble polymers, fatty acid esters, trimethylglycine, protein hydrolysates, amino acids and derivatives thereof, urea, phospholipids, glycolipids, ceramides, and the like.

  Examples of other components include animal and vegetable oils and fats, powders, antiseptic / preservatives, pigments, pH adjusters, ultraviolet absorbers, and animal and plant extracts.

  Specific examples of the composition for external use of the present invention include a pharmaceutical composition, a quasi-drug composition, a cosmetic composition, an oral composition and the like. Among these, in the composition for oral cavity which should consider not only the external appearance but also the taste preference, it has a comprehensively excellent effect.

  Examples of the present invention will be described below, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

Azulene Compound Stability and Influence on Preference of Composition for External Use Compositions shown in Table 1 were prepared and used for testing. The evaluation was performed by measuring the appearance of the composition and the residual amount of the azulene compound. The appearance of the composition was filled in a glass bottle and allowed to stand at 55 ° C. for 3 months (3M), and then a visual evaluation using a 5 ° C. product as a standard was performed according to the following criteria. The stability of the azulene compound was filled in the composition shown in Table 1 in a glass screw tube (6 ml capacity), completely shielded from light with aluminum foil, and allowed to stand at 55 ° C. and 5 ° C. One month (1M) after standing, the azulene compound present in the composition was quantified, and the amount of residual azulene in the 55 ° C standing product was calculated with the 5 ° C standing product as 100. The overall evaluation was according to the following criteria. The obtained results are shown in Tables 1 and 2.
Method for quantifying azulene compound The quantification was carried out using a high performance liquid chromatograph under the following conditions.
Equipment used High performance liquid chromatograph LC-10AS (Shimadzu Corporation)
Detector Ultraviolet absorptiometer-Measurement wavelength 292nm
Column ODS column 15cm in length
Column temperature 40 ° C
Mobile phase Tetrabutylammonium hydroxide solution
(Water / ethanol mixture)
Flow rate Set the retention time of sodium azulene sulfonate to about 15 minutes

Appearance evaluation criteria (evaluation of the degree of color retention unique to Azulene)
5: Accepts the same color tone as the standard product
4: Slightly faded compared to standard products
3: Permits clear fading compared to standard products
2: Slight coloring is observed
1: Coloring is not recognized (colorless)

Comprehensive evaluation ◎ Azulene residual amount of products left at 55 ° C and 1M is 99.0% or more, and appearance evaluation is 5
○ Residual amount of azulene left at 55 ° C 1M is 95.0% or more and 4
Or the azulene residual amount of the product left at 55 ° C. and 1M is 95.0% or more and less than 99.0%,
And appearance evaluation is 5
× Other than above

  As shown in Tables 1 and 2, a composition comprising sodium azulenesulfonate sodium coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine and alkylglycoside and / or polyoxyethylene (60) hydrogenated castor oil is stable over time. It was found that there is an effect of improving the properties and suppressing the appearance change (fading) of the composition.

Effect of Azulene Compound Stability and Oral Composition on Preference The dentifrice composition shown in Table 3 was produced according to a conventional method and subjected to the test. Evaluation was carried out by sensory evaluation of the dentifrice composition and appearance evaluation after leaving at 55 ° C. for 3M. Sensory evaluation evaluated the irritation | stimulation and bitter taste which were felt in the oral cavity after brushing for 3 minutes based on the following reference | standard. The appearance evaluation after leaving at 55 ° C. for 3M was performed using the same method and standard as described above. The overall evaluation was according to the following criteria. The obtained results are shown in Table 3.

Evaluation criteria for sensory evaluation 5 Feel little bitterness / irritant 4 Feel slightly bitterness / irritant 3 Feel bitterness / irritant but don't mind 2 Feel bitterness / stimulation slightly 1 Feel strongly bitterness / irritation

Overall evaluation ◎ All evaluations are 4 or more ○ All evaluations are 3 or more and 1 or more 3 evaluations × Other than the above

  As shown in Table 3, a composition in which sodium azulenesulfonate was mixed with palm oil fatty acid amidopropyldimethylaminoacetic acid betaine and alkyl glycoside and / or polyoxyethylene (60) hydrogenated castor oil was used to change the appearance of the dentifrice composition ( It has been found that favorable fading can be obtained by suppressing (fading).

  Hereinafter, although the formulation example of this invention is described, this invention is not limited to the following example. In the following, “%” means “mass%” unless otherwise specified.

Formulation Example 1 Mouthwash

Component amount
Sodium azulene sulfonate 0.01
Polyoxyethylene (60) hydrogenated castor oil 0.4
Stearate amidopropyldimethylaminoacetate betaine 0.06
Glycerin 10
Propylene glycol 3
Sodium benzoate 0.2
Sodium citrate 0.07
Cetylpyridinium chloride 0.05
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 2 Mouthwash

Component amount
Sodium azulene sulfonate 0.02
Polyoxyethylene (40) hydrogenated castor oil 1
Laminate amidopropyldimethylaminoacetic acid betaine 0.01
Glycerin 10
Propylene glycol 3
Methylparaben 0.2
Cetylpyridinium chloride 0.05
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Sodium hydroxide
Purified water balance
Total 100.0
Adjust to pH 7.5 with sodium hydroxide

Formulation Example 3 Mouthwash

Component amount
Sodium azulene sulfonate 0.001
Polyoxyethylene (40) hydrogenated castor oil 2
Coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine 2
Glycerin 10
Propylene glycol 3
Sodium benzoate 0.2
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 4 Mouthwash

Component amount
Sodium azulene sulfonate 0.02
Polyoxyethylene (20) hydrogenated castor oil 0.1
Palm kernel oil fatty acid amidopropyldimethylaminoacetic acid betaine 0.1
Glycerin 10
Propylene glycol 3
Sodium benzoate 0.2
Cetylpyridinium chloride 0.05
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 5 Mouthwash

Component amount
Sodium azulene sulfonate 0.5
Polyoxyethylene (20) hydrogenated castor oil 4.5
Oleic acid amidopropyldimethylaminoacetic acid betaine 0.5
Glycerin 10
Propylene glycol 3
Methylparaben 0.2
Benzethonium chloride 0.01
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 6 Mouthwash

Component amount
Sodium azulene sulfonate 0.1
Alkyl (8-10) glycosides 0.1
Myristyldimethylaminoacetic acid betaine 0.3
Glycerin 10
Propylene glycol 3
Sodium benzoate 0.2
Cetylpyridinium chloride 0.05
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 7 Mouthwash

Component amount
Sodium azulene sulfonate 0.05
Alkyl (12-16) glycosides 4.5
Lauryldimethylaminoacetic acid betaine 0.1
Glycerin 10
Propylene glycol 3
Sodium benzoate 0.2
Benzalkonium chloride 0.01
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 8 Mouthwash

Component amount
Sodium azulene sulfonate 1
Polyoxyethylene (60) hydrogenated castor oil 0.5
Palm oil fatty acid amidopropyldimethylaminoacetic acid betaine 0.2
Glycerin 5
Propylene glycol 2
L-Menthol 0.5
Sodium benzoate 0.2
Cetylpyridinium chloride 0.05
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.01
Fragrance 0.1
Purified water balance
Total 100.0

Formulation Example 9 Gel Agent

Component amount
Sodium azulene sulfonate 0.5
Polyoxyethylene (60) hydrogenated castor oil 0.4
Oleic acid amidopropyldimethylaminoacetic acid betaine 0.3
Glycerin 10
1,3-propanediol 3
Hydroxyethyl cellulose 1
Sodium benzoate 0.2
Cetylpyridinium chloride 0.05
Sodium citrate 0.07
Citric anhydride 0.01
Saccharin sodium 0.2
Fragrance 0.3
Purified water balance
Total 100.0

Formulation Example 10 Gel

Component amount
Sodium azulene sulfonate 1
Polyoxyethylene (60) hydrogenated castor oil 0.5
Coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine 1
Glycerin 25
Sorbit 25
Hydrogenated starch degradation product 10
Inositol 5
1,3-butylene glycol 2
Sodium polyacrylate 1.5
Xanthan gum 0.1
Methyl benzoate 0.2
Purified water balance
Total 100.0

Formulation Example 11 Skin Cream

Component amount
Sodium azulene sulfonate 2
Polyoxyethylene (60) hydrogenated castor oil 3
Coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine 0.01
White petrolatum 10
Concentrated glycerin 10
Cetanol 3
Glyceryl monostearate 2
Squalane 2
1,3-butylene glycol 1
Neopentyl glycol dicaprate 1
Purified water balance
Total 100.0

Formulation Example 12 Latex

Component amount
Sodium azulene sulfonate 1.5
Polyoxyethylene (60) hydrogenated castor oil 1.5
Coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine 0.05
Concentrated glycerin 10
1,3-butylene glycol 5
Glyceryl monostearate 3.5
Cetanol 3
Squalane 2
Sorbitan monostearate 1
Purified water balance
Total 100.0

Formulation Example 13 Lotion

Component amount
Sodium azulene sulfonate 1
Polyoxyethylene (60) hydrogenated castor oil 0.3
Laminate amidopropyldimethylaminoacetic acid betaine 0.01
Ethyl alcohol 5
Concentrated glycerin 4
Trimethylglycine 3
Polyoxyethylene (20) sorbitan monostearate 1
Phenoxyethanol 0.7
Polyethylene glycol (average molecular weight 100,000) 0.1
Citric acid 0.08
Sodium citrate 0.08
Perfume 0.03
Purified water balance
Total 100.0

Claims (3)

A composition for external use, comprising one or more azulene compounds selected from the group consisting of guaiazulene and guaiazulene sulfonate, polyoxyethylene hydrogenated castor oil (A), and betaine acetate surfactant (B). (However, the pH of the composition for external use is 7 or more.) The blending amount of the polyoxyethylene hydrogenated castor oil (A) is 0.5 to 2.0 % by mass, and the blending amount of the betaine acetate surfactant (B) is 0.05 to 1.5 % by mass. The composition for external use according to claim 1. The total amount of the polyoxyethylene hydrogenated castor oil (A) and the betaine acetate type surfactant (B) is 1.0 to 4.0% by mass, either 1 or 2, The composition for external use according to Item.