JP2014214107A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition which can impart an excellent cool feeling as well as which can prevent a precipitation of a crystal, and which is also excellent in preservation stability by preventing a fluid separation after being stored at a high temperature, while improving a texture of a dentifrice.SOLUTION: A dentifrice composition contains (A) a sugar alcohol whose solubility for 100 g of water at 20°C is 10 g to 120 g, (B) a glycerol and/or a sorbit, (C) a medium chain fatty acid triglyceride, and (D) water.

Description

  The present invention relates to a dentifrice composition that can give an excellent cool feeling, has no crystal precipitation, has a good dentifrice texture, and does not have liquid separation after high-temperature storage and has excellent storage stability.

  In general, one of the purposes of cleaning the oral cavity using a dentifrice composition is to obtain a refreshing feeling in the oral cavity, and a dentifrice composition having a more refreshing feeling is desired. The dentifrice composition gives a refreshing sensation by blending fragrance ingredients such as menthol and ethanol, giving a refreshing feeling, but when these fragrance ingredients and ethanol are blended in large amounts, irritation and bitterness in the oral cavity There was a problem that became stronger.

  In order to solve these problems, a dentifrice composition containing an endothermic hydration component has been proposed (Patent Document 1). This is because a cool sensation is produced in the oral cavity due to an endothermic reaction when the endothermic hydration component dissolves in the dentifrice. Patent Documents 2 to 6 propose a dentifrice composition that is excellent in coolness and coolness by containing an endothermic hydration component (erythritol), water, and a binder.

JP 2000-191383 A JP-A-2005-281306 JP 2007-63187 A JP 2007-63188 A JP 2007-70259 A JP 2007-70261 A

However, although these proposed compositions are excellent in the coolness and non-stickiness at the time of dentifrice, there are problems such as crystal precipitation, poor texture of the dentifrice, and separation at high temperature storage.

As a result of intensive studies to solve the above problems, the present inventors have found that a sugar alcohol having a solubility in 100 g of water at 20 ° C. of 10 to 120 g, glycerin and / or sorbit, medium-chain fatty acid triglyceride, water Containing a surprisingly cool feeling, can prevent crystal precipitation, improve the texture of the toothpaste, and suppresses liquid separation after storage at high temperatures. It was found that a product was obtained.

Accordingly, the present invention provides the following dentifrice composition.
Claim 1:
(A) A dentifrice composition comprising a sugar alcohol having a solubility in 100 g of water at 20 ° C. of 10 g to 120 g, (B) glycerin and / or sorbit, (C) medium chain fatty acid triglyceride, and (D) water. .
Claim 2:
The dentifrice composition according to claim 1, wherein the ratio (A) / (D) is 1.5 to 3.0.
Claim 3:
The dentifrice composition of Claim 1 or 2 which contains 15-40 mass% of (A) component, 10-35 mass% of (B) component, and 0.05-2 mass% of (C) component.

According to the present invention, an excellent cooling feeling can be imparted, crystal precipitation can be prevented, the texture of toothpaste can be improved, and liquid separation after storage at high temperatures is suppressed, resulting in excellent storage stability. Toothpaste compositions can be provided.

  The present invention will be described in further detail below. The dentifrice composition of the present invention is suitably prepared as a dentifrice such as a toothpaste, a liquid dentifrice, and a toothpaste, particularly a toothpaste, and (A) a sugar alcohol having a solubility in 100 g of water at 20 ° C. of 10 to 120 g, ( B) Contains glycerin and / or sorbit, (C) medium chain fatty acid triglyceride, and (D) water as essential components.

  Examples of the sugar alcohol having a solubility of 10 g to 120 g of the component (A) in 100 g of water at 20 ° C. include erythritol, xylitol, mannitol, reduced palatinose, maltitol, and the like. Can be used. The shape is not particularly limited, and may be powdery or granular, and may be dispersed in a solid form in the dentifrice composition and dissolved in the oral cavity during toothpaste. Among the sugar alcohols, erythritol and xylitol are particularly preferable. Specifically, commercial products manufactured by Mitsubishi Chemical Foods Co., Ltd. can be used as erythritol, and DuPont can be used as xylitol.

The blending amount of the sugar alcohol is 15 to 40% (mass%, the same applies hereinafter), preferably 20 to 35%, more preferably 20 to 30% of the entire composition. If the blending amount is less than 15%, a sufficient cooling sensation when brushing teeth and a refreshing feeling after rinsing cannot be obtained. If the blending amount exceeds 40%, the hardness when pushing the toothpaste out of the tube becomes hard, and the texture of the toothpaste worsens There is a tendency.
As the component (B), sorbitol and glycerin, those commonly used in dentifrice compositions can be used. Generally, sorbit is blended as a 60-70% aqueous solution, and glycerin is blended as an approximately 85% aqueous solution or 95% or more concentrated glycerin. Specifically, commercially available products can be used. For example, Sorbit is available as NEOSORB 70 / 02SB manufactured by Rocket Co., Ltd., and D-sorbitol solution (70%) manufactured by Towa Kasei Kogyo Co., Ltd. It can be obtained from Co., Ltd.

  The blending amount of sorbit and / or glycerin is 10 to 35% of the total composition in terms of pure content, and particularly preferably 15 to 25%. If the blending amount is less than 10%, the hardness when extruding the toothpaste from the tube becomes hard, and if it exceeds 35%, the texture of the dentifrice tends to be poor.

  The medium chain fatty acid triglyceride of component (C) is a triglyceride composed of a fatty acid having 6 to 12 carbon atoms, and examples thereof include caprylic acid triglyceride, caprylic acid / capric acid triglyceride, and caprylic acid / capric acid / lauric acid triglyceride. . Specifically, commercially available products such as Cocoonado RK, Coconut MT, and Coconut ML manufactured by Kao Corporation can be used.

  (C) The compounding quantity of the medium chain fatty acid triglyceride of component is 0.05 to 2% of the whole composition, Preferably it is 0.1 to 1%, More preferably, it is 0.2 to 0.5%. If it is less than 0.05%, liquid separation may occur, and if it exceeds 2%, foaming tends to deteriorate.

  (D) The compounding quantity of the water which is a component is 5 to 20% of the whole composition, Preferably it is 7 to 15%. If it is less than 5%, the hardness when the toothpaste is pushed out from the tube becomes hard, and if it exceeds 20%, the texture of the toothpaste tends to be poor.

  Furthermore, the ratio (A / D) of erythritol to water is preferably 1.5 to 3.0. If it is less than 1.5, the texture of dentifrice will worsen, and if it exceeds 3.0, it exists in the tendency when the hardness at the time of pushing out toothpaste from a tube becomes hard.

  The dentifrice composition of this invention can mix | blend the well-known component according to another dosage form as needed in addition to the said component. For example, abrasives, binders, surfactants, sweeteners, preservatives, dyes, fragrances, various active ingredients, and the like are blended.

  Examples of the abrasive include silica-based abrasives such as silica gel, precipitated silica, and aluminosilicate, dicalcium phosphate dihydrate and anhydrous, tertiary calcium phosphate, tertiary magnesium phosphate, tetrabasic calcium phosphate, calcium pyrophosphate, etc. Examples thereof include calcium phosphate compounds, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, zirconium silicate, hydroxyapatite, and synthetic resin abrasives.

  The blending amount of these abrasives is usually 0 to 50% of the whole composition, in particular, 10 to 50% for toothpaste and 0 to 30% for liquid toothpaste.

  Examples of the binder include xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin, sodium polyacrylate, and the like. Of these, hydroxyethyl cellulose and carrageenan are preferable. 0.1-5% is suitable for the compounding quantity of these binders.

  As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended. Specifically, examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, and sodium α-olefin sulfonate. Etc.

  Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Ether type or ester type activator such as polyhydric alcohol fatty acid ester such as fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, And fatty acid alkanolamides such as lauric acid diethanolamide.

  Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.

  The blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.

  Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

  Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as o-acetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above.

  Various active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphate, glucanases such as dextranase and mutanase, and allantochlorhydroxyaluminum. , Hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, acetic acid dl-tocophenol, α-bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid Copper compounds such as copper chlorophyllin sodium and copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, Sodium phosphate, zeolite, amylase, methoxyethylene, maleic anhydride copolymer, polyvinyl pyrrolidone, epidihydrocholesterine, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, sweet cherry extract, buckwheat extract, clove, Examples include extracts such as rosemary, ougon, safflower. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. In addition, glycerin was a 98% solution and sorbit was a 70% solution, and the blending amounts in the table shown below were expressed as pure amounts.
[Examples and Comparative Examples]
The dentifrice compositions shown in Tables 1 to 3 were prepared and evaluated by the following methods. The results are shown in Tables 1-3.
Preparation method of dentifrice composition:
Preparation of the dentifrice composition was carried out by dissolving a water-soluble substance such as sodium fluoride and sorbite solution in purified water, and separately adding a solution in which a binder was dispersed in polyethylene glycol and stirring. Then, a fragrance | flavor, an abrasive | polishing agent, etc. were added, and also it stirred under pressure reduction (pressure 4kPa), and obtained the dentifrice composition. For the production, a 1.5 L kneader (manufactured by Ishiyama Kogakusha Co., Ltd.) was used.
Raw materials used:
The detail of each component used for preparation of a dentifrice composition is shown below.
(A1) Erythritol; Cargill Erythritol (A2) Xylitol: Danisco Xylitol (C1) Caprylic / Capric triglyceride: Cognis MYRITOL 318
(C2) Caprylic acid triglyceride: Actor M2 manufactured by Riken Vitamin
For other ingredients, those conforming to the Quasi-drug Raw Material Standard 2006 were used.
Evaluation method;
(1) Extrusion Hardness (1-1) Evaluation Method Evaluation was made by a sensory test using five specialized panelists. The test dentifrice composition filled in a laminate tube having a diameter of 8 mm was stored at 50 ° C. for one month, and then evaluated for ease of extrusion when put out on a toothbrush according to the following criteria. Judgment was made according to the following table from the average score of the results of five people.
(1-2) Evaluation criteria and judgment criteria Evaluation criteria;
5 points: Easily extrude 4 points: Difficult to extrude slightly 3 points: Difficult to extrude 2 points: Very difficult to extrude 1 point: Criteria for non-existence ◎: Average point 4.5 to 5.0 points ○: Average Points: 4.0 points or more and less than 4.5 points Δ: Average point is 3.0 points or more and less than 4.0 points ×: Average point is less than 3.0 points (2) Appearance of dentifrice (2-1) Evaluation method Evaluation was conducted by a sensory test using five professional panelists. The test dentifrice composition filled in a laminated tube having an aperture of 8 mm was stored at 60 ° C. for 1 week, and then the appearance when it was put out on a toothbrush was evaluated according to the following criteria. Judgment was made according to the following table from the average score of the results of five people.
(2-2) Evaluation criteria and judgment criteria Evaluation criteria;
5 points: Precipitation of crystals is not observed and texture is good 4 points: Precipitation of crystals is not observed, but texture is slightly bad 3 points: Precipitation of crystals is slightly recognized and texture is slightly bad 2 points: Precipitation of crystals is observed and texture is poor 1 point: Criterion of crystal precipitation is considerably recognized and texture is poor ◎: Average point is 4.5 to 5.0 points ○: Average point is 4.0 points More than less than 4.5 points △: Average score is 3.0 or more and less than 4.0 points ×: Average score is less than 3.0 points (3) Dentifrice liquid separation (3-1) Evaluation method 5 expert panelists Evaluation was made by the sensory test used. After the test dentifrice composition filled in an 8 mm diameter laminated tube was stored at 50 ° C. for one month, the exudation of the liquid from the dentifrice when it was put on a toothbrush was evaluated according to the following criteria. Judgment was made according to the following table from the average score of the results of five people.
(3-2) Evaluation Criteria and Judgment Criteria Evaluation Criteria 5 points: No exudation is observed 4 points: Exudation is slightly recognized 3 points: Exudation is recognized 2 points: Exudation is considerably recognized 1 Point: Criteria for liquid coming out of tube ◎: Average point is 4.5 or more and 5.0 or less ○: Average point is 4.0 or more and less than 4.5 △: Average point is 3.0 Less than 4.0 points x: Average point is less than 3.0 points (4) Cool feeling (4-1) Evaluation method Evaluation was made by a sensory test using five professional panelists. The test dentifrice composition filled in a laminated tube having a diameter of 8 mm was placed on a toothbrush by about 1.5 cm, used for 2 minutes by a method of brushing normal teeth, and the cooling feeling during brushing was evaluated according to the following criteria. Judgment was made according to the following table from the average score of the results of five people.
(4-2) Evaluation criteria and judgment criteria Evaluation criteria;
5 points: Feel cool enough 4 points: Feel cool 3 points: Feel slightly cool 2 points: Feel almost no cool 1 point: Criteria not feel cool at all ◎: Average score is 4 .5 point or more and 5.0 point or less ○: Average point is 4.0 point or more and less than 4.5 point Δ: Average point is 3.0 point or more and less than 4.0 point ×: Average point is less than 3.0 point 1

Table 2

Table 3

  From the results of Table 3, when there is no sugar alcohol having a solubility in 100 g of water at 20 ° C. that is (A) component of 10 g to 120 g, no cooling sensation is obtained, and glycerin and / or component (B) is not obtained. In the absence of sorbit, the texture was poor, and liquid separation occurred when there was no medium chain fatty acid triglyceride as component (C). Furthermore, when there is no water which is (D) component, the extrusion hardness from dentifrice will become hard and texture will worsen. In contrast, the dentifrice compositions (Examples: Tables 1 and 2) containing appropriate amounts of each component have excellent cooling feeling, no crystal precipitation, good dentifrice texture, and high temperature. It was found to be a good dentifrice composition without liquid separation after storage.

A prescription example is shown below.
<Prescription Example 1>
Erythritol 25.0
Glycerin 20.0
Caprylic acid / Capric acid triglyceride 0.2
Purified water 12.5
Precipitated silica 2.0
Fine calcium carbonate 1.0
Sodium monofluorophosphate 0.76
Isopropyl methylphenol 0.05
Dipotassium glycyrrhizinate 0.05
Sodium lauryl sulfate 2.5
Polyoxyethylene (20 mol) hydrogenated castor oil 0.3
Carrageenan 0.3
Hydroxyethyl cellulose 0.4
Polyethylene glycol # 400 2.0
Highly polymerized polyethylene glycol 0.05
Saccharin sodium 0.05
Methyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.02
Sodium silicate 0.05
Fragrance 1.5
Calcium carbonate balance ――――――――――――――――――――――――――――――
Total 100.0
<Prescription Example 2>
Erythritol 25.0
Glycerin 15.0
Sorbit 5.0
Caprylic acid triglyceride 0.3
Purified water 12.0
Precipitated silica 1.5
Thickening silica 0.2
Fine calcium carbonate 1.5
Sodium monofluorophosphate 0.76
Isopropyl methylphenol 0.05
Dipotassium glycyrrhizinate 0.05
Sodium lauryl sulfate 2.5
Polyoxyethylene (20 mol) hydrogenated castor oil 0.3
Carrageenan 0.3
Hydroxyethyl cellulose 0.3
Polyethylene glycol # 400 2.0
Highly polymerized polyethylene glycol 0.1
Saccharin sodium 0.05
Methyl paraoxybenzoate 0.1
Ethyl paraoxybenzoate 0.1
Sodium silicate 0.05
Fragrance 1.0
Calcium carbonate balance ――――――――――――――――――――――――――――――
Total 100.0
Each of the above-mentioned formulation examples was an excellent dentifrice composition having excellent cooling feeling, no crystal precipitation, good dentifrice texture, and no liquid separation after high-temperature storage.

Claims (3)

  (A) A dentifrice comprising a sugar alcohol having a solubility in 100 g of water at 20 ° C. of 10 g to 120 g, (B) glycerin and / or sorbit, (C) medium chain fatty acid triglyceride, and (D) water. Composition.   The dentifrice composition according to claim 1, wherein the ratio (A) / (D) is 1.5 to 3.0. The dentifrice composition of Claim 1 or 2 which contains 15-40 mass% of (A) component, 10-35 mass% of (B) component, and 0.05-2 mass% of (C) component.