JPWO2017094582A1 - Oral composition - Google Patents

Abstract

(A) α-olefin sulfonate, (B) peppermint oil, and (C) the following (C-1) and (C-2) component (C-1) a lactone having 6 to 12 carbon atoms. 1 type or 2 types or more (C-2) 1 type or 2 types or more chosen from C2-C12 aldehyde are contained, and (C-1) / (C-2) is 20-1 as mass ratio. The composition for oral cavity in which the bitterness by (alpha) -olefin sulfonate is suppressed continuously and the flavor stability in time is excellent is provided.

Description

  The present invention relates to a composition for oral cavity in which bitterness due to α-olefin sulfonate is continuously suppressed and flavor stability over time is excellent.

  Generally, it is known that a caries biofilm is an aggregate of bacteria. Therefore, in order to remove the caries biofilm, it is important to disperse the aggregates of bacteria.

  So far, the applicant has focused on α-olefin sulfonates such as sodium tetradecenesulfonate as an effective component for dispersing and removing oral biofilms, and has proposed oral compositions containing this. Patent Document 1 (Japanese Patent Laid-Open No. 2013-151474) discloses an oral composition containing an α-olefin sulfonate and an acylamino acid salt and / or arginine, and Patent Document 2 (Japanese Patent Laid-Open No. 2015-20970). Include an oral composition containing an α-olefin sulfonate and an acylamino acid salt and / or arginine; Patent Document 3 (International Publication No. 2015/008823) includes an α-olefin sulfonate and condensed phosphorus. Oral compositions containing acid salts and / or amphoteric surfactants have been proposed. These have an excellent oral biofilm removal effect and have reduced bitterness during use.

JP 2013-151474 A Japanese Patent Laying-Open No. 2015-20970 International Publication No. 2015/008823

  However, there is still room for improvement regarding the bitterness control of the oral composition containing the α-olefin sulfonate, and the flavor stability over time has not always been sufficient.

  This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity which the bitterness by (alpha) -olefin sulfonate salt is suppressed continuously and the flavor stability in time is excellent.

  As a result of intensive studies to achieve the above object, the present inventors have found that by combining peppermint oil and a specific fragrance with an α-olefin sulfonate, a remarkable effect can be exerted on the above problems. It was. That is, (B) peppermint oil, (C) (C-1) lactone having 6 to 12 carbon atoms, and (C-2) carbon number in an oral composition containing (A) α-olefin sulfonate. 8-12 aldehydes are blended, and (C-1) / (C-2) is 20 to 1,000,000 as a mass ratio, so that the bitterness due to α-olefin sulfonate is maintained even after use. It has been found that the present invention has been suppressed and deterioration of the flavor of the preparation over time has been prevented to give excellent flavor stability, and the present invention has been made.

In this invention, the combination of the fragrance | flavor of (B) component and (C) component ((C-1) and (C-2) component) acts on (A) component specifically, Masks the bitter taste continuously and prevents the flavor of the preparation from deteriorating over time due to the component (A) without causing deterioration odor or base odor, without changing the flavor at the time of preparation. It can be stably maintained over a long period of time. In this case, as can be seen from the results of Comparative Examples described later, when the lactone and aldehyde fragrances are used in combination with the component (A), the flavor changes over time, and the deterioration odor and substrate odor are strongly felt. When the components (C-1) and (C-2) are used in an appropriate ratio and combined with the component (B), the flavor is surprisingly kept stable without causing the above-described flavor change (A ) The bitterness due to the ingredients can be continuously suppressed.
Thereby, according to the present invention, as shown in the examples described later, the bitterness is suppressed not only after use in the oral cavity but also after use, specifically after being brushed, and after several minutes have passed, Even if the prepared preparation is stored at 50 ° C. for 3 months, the fragrance and flavor are not changed, and excellent flavor stability is exhibited in which neither a deteriorated odor nor a substrate odor is felt.
In the present invention, the flavor stability that has been dramatically improved, which cannot be achieved simply by the addition of a general fragrance for oral cavity, is imparted, and the above-mentioned remarkable effects are provided. Furthermore, the composition for oral cavity of the present invention can effectively express the oral biofilm removing action by α-olefin sulfonate, and is suitable for oral biofilm suppression.

Accordingly, the present invention provides the following oral composition.
[1]
(A) an α-olefin sulfonate;
(B) peppermint oil;
(C) Components (C-1) and (C-2) below (C-1) One or more selected from lactones having 6 to 12 carbon atoms (C-2) Aldehydes having 8 to 12 carbon atoms 1 or 2 or more types chosen from these, (C-1) / (C-2) is 20-1,000,000 as mass ratio, The composition for oral cavity characterized by the above-mentioned.
[2]
The composition for oral cavity according to [1], wherein the component (A) is sodium α-olefin sulfonate having 14 to 16 carbon atoms.
[3]
The component (C-1) is one or more selected from γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone and γ-dodecalactone. The oral cavity according to [1] or [2], wherein (C-2) component is one or more selected from linear octanal, nonanal, decanal, undecanal and dodecanal Composition.
[4]
The composition for oral cavity according to any one of [1] to [3], containing 0.002 to 1% by mass of component (C-1) and 0.00000001 to 0.003% by mass of component (C-2). .
[5]
The composition for oral cavity according to any one of [1] to [4], containing 0.1 to 1% by mass of component (A) and 0.0001 to 1% by mass of component (B).
[6]
Furthermore, the composition for oral cavity in any one of [1]-[5] whose (C) / (A) is 0.002-10 as mass ratio.
[7]
Furthermore, the composition for oral cavity in any one of [1]-[6] whose (C) / (B) is 0.004-334 as mass ratio.
[8]
The composition for oral cavity according to any one of [1] to [7], which is a dentifrice.

  ADVANTAGE OF THE INVENTION According to this invention, the bitterness by alpha-olefin sulfonate can be continuously suppressed, and the oral cavity composition which is excellent in flavor stability by preventing the flavor deterioration of a formulation over time can be provided. The composition for oral cavity of the present invention can be suitably used for oral biofilm suppression.

  The present invention will be described in further detail below. The composition for oral cavity of the present invention comprises (A) α-olefin sulfonate, (B) peppermint oil, (C) (C-1) a lactone having 6 to 12 carbon atoms and (C-2) having 8 to 8 carbon atoms. Contains 12 aldehydes.

  (A) As the α-olefin sulfonate, an alkali metal salt such as sodium salt or potassium salt of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and preferably α-olefin having 14 carbon atoms. Sulfonates, especially sodium salts (generic name; sodium tetradecene sulfonate). Commercially available products that can be used for oral preparations can be obtained, and for example, trade name “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

  The blending amount of the component (A) α-olefin sulfonate is preferably 0.1 to 1% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.2 to 0.4%. . The amount of oral biofilm removal increases as the amount added increases, but if too much is added, bitterness may be strongly expressed. If it is 1% or less, bitterness can be masked sufficiently and the flavor is sufficiently stabilized. it can.

(B) Peppermint oil can use commercial items, such as an essential oil by Takasago Fragrance Industrial Co., Ltd., for example.
The blending amount of peppermint oil is preferably 0.0001 to 1%, more preferably 0.003 to 0.7% of the entire composition. As the blending amount increases, the bitterness can be masked and the flavor can be stabilized. When the content is 0.0001% or more, the bitterness is sufficiently suppressed and the flavor stability is excellent. Furthermore, a satisfactory refreshing feeling can be imparted. When it is 1% or less, it is possible to sufficiently prevent the stimulation from becoming strong.

  The component (C) is (C-1) a lactone having 6 to 12 carbon atoms and (C-2) an aldehyde having 8 to 12 carbon atoms. In the present invention, it is important to use the components (C-1) and (C-2) together, and when the component (C-1) is lacking, the bitterness cannot be continuously suppressed, and the component (C-2) When lacking, the bitterness at the time of use cannot be suppressed. Moreover, when (C-1) or (C-2) component is missing, even if it contains (B) component, the flavor stability of a formulation is inferior and the objective of this invention is not achieved.

(C-1) Specific examples of the lactone having 6 to 12 carbon atoms include hexalactone, heptalactone, octalactone, nonalactone, decalactone, undecalactone, and dodecalactone. A combination of more than one species can be used. In particular, octalactone, nonalactone, decalactone, and undecalactone can be suitably used from the viewpoint of being particularly effective in sustaining bitterness suppression, and all of them are particularly preferably γ-form.
As these lactones, commercially available products such as those manufactured by Iwata Fragrance Co., Ltd. and Takasago Fragrance Industry Co., Ltd. can be used.

  (C-1) Component lactone content is preferably 0.002 to 1% of the total composition, more preferably 0.01 to 1.0%, and still more preferably 0.01 to 0.3%. is there. The greater the amount, the more the bitterness can be masked and the flavor can be stabilized. If it is 0.002% or more, a sufficient bitterness suppressing effect and flavor stability can be obtained. If it is 1% or less, it is possible to sufficiently prevent the taste of the product itself from developing strongly.

(C-2) Specific examples of the aldehyde having 8 to 12 carbon atoms include linear octanal, nonanal, decanal, undecanal, and dodecanal, and one of these may be used alone or in combination of two or more. Can be used. Of these, octanal and nonanal can be preferably used because they are particularly effective for suppressing bitterness during use. Moreover, the aldehyde of (C-2) component is excellent in the point of especially the bitterness suppression in use.
As these aldehydes, commercially available products such as those manufactured by Inoue Fragrance Co., Ltd. can be used.

  (C-2) The compounding quantity of the aldehyde of a component has preferable 0.00000001 to 0.003% of the whole composition, and 0.0000003 to 0.003% is more preferable. As the blending amount increases, the bitterness can be masked and the flavor can be stabilized, and when it is 0.00000001% or more, a sufficient bitterness suppressing effect and flavor stability can be obtained. If it is 0.003% or less, it is possible to sufficiently prevent the strong taste of itself.

  (C-1) and (C-2) indicating the blending ratio of the components (C-1) and (C-2) are 20 to 1,000,000 as a mass ratio, preferably 100 to 1,000. 2,000, more preferably 2,000 to 300,000. Within the above range, the bitterness suppressing effect and flavor stability are more excellent. If it is less than 20, the bitterness suppressing effect and its sustainability cannot be satisfactorily exhibited. If it exceeds 1,000,000, the effect of suppressing bitterness will not be satisfactorily exhibited, and a better feeling of use cannot be obtained.

  Furthermore, in this invention, (C) / (A) which shows the mixture ratio of (A) component and (C) component ((C-1) and (C-2) component) is 0.002 as mass ratio. As mentioned above, it is preferable that it is especially 0.03-10, especially 0.03-4. Within the above range, the bitterness suppressing effect and flavor stability are more excellent. If less than 0.002, the bitterness suppressing effect and its sustainability may not be satisfactorily exhibited.

  Moreover, (C) / (B) which shows the mixture ratio of (B) component and (C) component ((C-1) and (C-2) component) is 0.004-334 as mass ratio. More preferably, it is 0.01-100, especially 0.01-4. Within this range, the bitterness suppressing effect and flavor stability are more excellent.

  In addition, in this invention, when (A) component is comparatively much 0.1% or more, especially 0.3-1% is mix | blended, (B) component is 0.2% or more, (C-1) component Is preferably 0.01% or more and the component (C-2) is preferably 0.000001% or more. Further, in this case, the component (C-1) is preferably decalactone and / or undecalactone, and the component (C-2) is preferably n-octanal or n-nonanal.

The oral composition of the present invention can be prepared in various dosage forms such as dentifrice, mouthwash, etc. in the form of liquid, liquid, paste, etc., but especially toothpaste, liquid toothpaste, liquid toothpaste, moisturized toothpaste, etc. Suitable as a dentifrice composition.
In addition, although a normal method can be employ | adopted for preparation, mix | blend both components previously specifying the compounding quantity of (C) component ((C-1), (C-2) component), and (B) component as a fragrance | flavor. After the preparation, it is preferable to add this to the component (A), and further to the mixture of optional addition components described later. In particular, the total amount of the components (C-1), (C-2) and (B) is very small. If it is difficult to mix, it is preferable to dilute and adjust to an arbitrary concentration with a trace amount of ethanol, and then add this to the mixture of component (A) and further optional components described below.
In this case, in addition to the above-mentioned components, other optional components according to the dosage form and the like can be appropriately blended within a range that does not hinder the effects of the present invention. For toothpastes, for example, surfactants, abrasives, thickeners, binders, sweeteners, preservatives, colorants, active ingredients, fragrances, and the like can be blended, and these ingredients are mixed with water. be able to.

As the surfactant, anionic surfactants other than α-olefin sulfonates, nonionic surfactants, and zwitterionic surfactants can be used.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, sodium N-lauroyl sarcosinate, sodium lauryl sulfoacetate, and the like. Particularly, alkyl sulfates such as sodium lauryl sulfate are solubilized. Can be preferably used.
Examples of the nonionic surfactant include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, lauric acid mono- or diethanolamide, sorbitan fatty acid ester and the like. In particular, polyoxyethylene hydrogenated castor oil (especially an average addition mole number of ethylene oxide of 10 to 30) and polyoxyethylene alkyl ether (especially an average addition mole number of ethylene oxide of 3 to 5, and an alkyl group having 16 to 18 carbon atoms). From the viewpoint of solubilization, it can be preferably used.
As the zwitterionic surfactant, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, N-alkylN-carboxymethylammonium betaine, 2-alkyl-1-hydroxyethylimidazoline betaine Sodium etc. are mentioned.
These surfactants can be used alone or in combination of two or more, and the blending amount is preferably 0.1 to 5%, particularly preferably 0.1 to 4% of the whole composition.

  Examples of abrasives include silica-based abrasives such as anhydrous silicic acid, silica gel, aluminosilicate, zirconosilicate, anhydrous calcium phosphate and dihydrate, tertiary calcium phosphate, tetracalcium phosphate, and eighth calcium phosphate. Calcium phosphate abrasive, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, magnesium carbonate, tribasic magnesium phosphate, zeolite, hydroxyapatite, fluoroapatite And synthetic resin abrasives. Of these, a silica-based abrasive is preferred. The blending amount of the abrasive is preferably 2 to 50%, particularly 10 to 40% of the entire composition.

  Examples of the thickening agent include sorbitol, propylene glycol, sugar glycol such as polyethylene glycol having a molecular weight of 200 to 6,000, ethylene glycol, and reduced starch saccharified product, and polyhydric alcohol. A compounding quantity is 5 to 50% of the whole composition normally.

  Examples of the binder include xanthan gum, sodium polyacrylate, sodium alginate, propylene glycol alginate, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite, polyvinyl alcohol, polyvinylpyrrolidone and the like. Can be mentioned. The blending amount of the binder is preferably 0.1 to 5% of the entire composition.

  Sweeteners include sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, etc., and preservatives include paraoxybenzoates such as butylparaben and ethylparaben, sodium benzoate, etc. Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like.

  As active ingredients, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, Chelating phosphoric acid such as tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, α-bisabolol, dihydrocholesterol, chlorohexidine salts, azulene, glycyrrhetin, glycyrrhetinic acid, glycyrrhizic acid and salts thereof, copper chlorophyllin sodium, chlorophyll, glycerophosphate, etc. Compounds, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, hydroxamic acid and its derivatives, sodium tripolyphosphate, methoxyethylene, epidihydrocholesterin, salt Benzethonium, allantoin aluminum chlorohydrate, ascorbic acid, lysozyme chloride, isopropyl methyl phenol, cetylpyridinium chloride, trichlorocarbanilide, zinc citrate, cork tree bark extract, and the like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

As a fragrance | flavor, in addition to peppermint oil, the lactone of (C-1) component, and the aldehyde of (C-2) component, other well-known fragrance | flavors can be added. For example, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, lavender oil , Rosemary oil, laurel oil, perilla oil, camomil oil, spearmint oil, Japanese-style light cargo oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil , Patchouli oil, paracres oil, iris concrete, rose absolute, orange flower absolute, vanilla absolute, patchouli absolute, and other natural fragrances, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid liquid Extraction, essence, powder fragrance, etc.) And limonene, pinene, butanol, isoamyl alcohol, hexenol, linalool, anethole, thymol, eugenol, carvone, menthone, pregon, foncon, cineol, hexanal, anisaldehyde, cinnamic aldehyde, ethyl acetate, ethyl butyrate, allyl Cyclohexane propionate, linalyl acetate, menthyl acetate, carbyl acetate, phenoxyethyl isobutyrate, methyl epijasmonate, methyl salicylate, ethyl salicylate, methyl anthranilate, ethyl methyl phenylglycidate, ethyl lactate, vanillin, maltol , Ambretlide, dimethyl sulfide, trimethylpyrazine, ethylthioacetate, vanillyl butyl ether Single flavors such as piperine, capsaicin, gingerol, spirantol, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, ume flavor, orange flavor, lemon flavor, grapefruit flavor, butter flavor, milk flavor, etc. It is possible to use a combination of known fragrance materials used in oral compositions such as blended fragrances.
Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It is preferable to use 0.000001 to 1% in a composition. Moreover, as a fragrance | flavor for perfume using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2% in a composition.
In addition, the said fragrance | flavor can use the compounding quantity of (B), (C-1), (C-2) component within the said range, respectively.

  The composition of the present invention may contain menthol. When mix | blending menthol, 0.1-0.8% of the whole composition is preferable, and, as for the compounding quantity, 0.3-0.7% is more preferable. (B) It is particularly preferable that the total amount of menthol including menthol in peppermint oil is within the above range. When it is 0.1% or more, a sufficient refreshing feeling is exhibited, and further, a refreshing feeling can be exhibited. It is suitable for preventing irritation | stimulation that it is 0.8% or less.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Oral compositions (dentifrice compositions) having the compositions shown in Tables 1 to 5 were prepared by a conventional method and evaluated by the following methods. In addition, after specifying the compounding quantity of (C) component ((C-1), (C-2) component), (B) component as a fragrance | flavor previously, mixing both components, this is prepared (A) It added to the mixture of the component and also the optional addition component mentioned later.
The results are shown in the table.

(1) Usability evaluation method Ten monitors determined the feeling of use (no bitterness) when the dentifrice composition was placed on a toothbrush and the oral cavity was washed, based on the following rating criteria. Furthermore, the feeling of use (sustainability of bitterness suppression) after elapse of 3 minutes after rinsing the oral cavity with water was determined based on the following criteria.
About each determination result, the average score of 10 persons was calculated | required and it determined based on the following evaluation criteria from the average score.

Bitterness rating criteria during use 4 points: No bitterness is felt in the oral cavity.
3 points: A bitter taste is felt in the oral cavity.
2 points: Bitter taste is felt in the oral cavity.
1 point: Feels very bitter in the oral cavity.
Evaluation criteria for lack of bitterness in use ◎: Average score is 3.5 or more and 4.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more 3 Less than 0 x: Average score is less than 2.0

Score standard for sustainability of bitterness suppression 4 points: No bitterness is felt in the oral cavity.
3 points: A bitter taste is felt in the oral cavity.
2 points: Bitter taste is felt in the oral cavity.
1 point: Feels very bitter in the oral cavity.
Evaluation criteria for sustainability of bitterness control ◎: Average score is 3.5 or more and 4.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more 3. Less than 0 x: Average score is less than 2.0

(2) Evaluation method of flavor stability Evaluation was performed by the following methods by 10 incense experts.
The prepared dentifrice composition was filled in a laminate tube and stored for 1 month at -5 ° C and 50 ° C. Thereafter, the dentifrice composition returned to room temperature was extruded onto a straw half paper, and the fragrance and flavor of the 50 ° C. preserved product were compared with the −5 ° C. preserved product, and flavor stability was determined based on the following rating criteria.
Furthermore, the fragrance and flavor of the 50 ° C. preserved product when the dentifrice composition was placed on a toothbrush, brushed and washed in the oral cavity were determined based on the following criteria compared to the −5 ° C. preserved product.
The average score of 10 people was calculated and determined from the average score according to the following evaluation criteria.
Score standard for flavor stability 5: No change in fragrance and flavor.
4: A slight change in fragrance and flavor is felt.
3: I feel a change in fragrance and flavor.
2: A considerable change in fragrance and flavor is felt, and a deteriorated odor and a base odor are slightly felt.
1: Strong change in fragrance and flavor is felt, and a deterioration odor and base odor are felt.
Evaluation criteria for flavor stability ◎: Average score is 3.5 or more and 5.0 or less ○: Average score is 3.0 or more and less than 3.5 △: Average score is 2.0 or more and 3.0 Less than ×: Average score is less than 2.0

Details of the raw materials used are shown below.
(A) Sodium tetradecene sulfonate; manufactured by Lion Specialty Chemicals Co., Ltd., trade name “K Lipolane PJ-400CJ”
(B) Peppermint oil; Takasago International Corporation (C-1) γ-hexalactone, γ-heptalactone, γ-octalactone
, Γ-undecalactone, γ-dodecalactone; Kamata Fragrance Co., Ltd.
Made
γ-nonalactone, γ-decalactone; manufactured by Takasago International Corporation (C-2) n-octanal, n-nonanal, decanal, undecaner
Le, Dodecanal; manufactured by Inoue Incense Co., Ltd.

Claims (8)

(A) an α-olefin sulfonate;
(B) peppermint oil;
(C) Components (C-1) and (C-2) below (C-1) One or more selected from lactones having 6 to 12 carbon atoms (C-2) Aldehydes having 8 to 12 carbon atoms 1 or 2 or more types chosen from these, (C-1) / (C-2) is 20-1,000,000 as mass ratio, The composition for oral cavity characterized by the above-mentioned.   The composition for oral cavity according to claim 1, wherein the component (A) is sodium α-olefin sulfonate having 14 to 16 carbon atoms.   The component (C-1) is one or more selected from γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone and γ-dodecalactone. The composition for oral cavity according to claim 1, wherein the component (C-2) is one or more selected from linear octanal, nonanal, decanal, undecanal and dodecanal. object.   The composition for oral cavity according to any one of claims 1 to 3, comprising 0.002 to 1% by mass of component (C-1) and 0.00000001 to 0.003% by mass of component (C-2).   The composition for oral cavity according to any one of claims 1 to 4, comprising 0.1 to 1% by mass of component (A) and 0.0001 to 1% by mass of component (B).   Furthermore, (C) / (A) is 0.002-10 as mass ratio, The composition for oral cavity of any one of Claims 1-5.   Furthermore, (C) / (B) is 0.004-334 as mass ratio, The composition for oral cavity of any one of Claims 1-6.   It is a dentifrice, The composition for oral cavity of any one of Claims 1-7.