JP2018203714A - Oral composition - Google Patents

Abstract

To provide oral compositions providing a hemostasis effect actual feeling which has the excellent feeling of the hemostasis effect and astringency, and also having an excellent stability in appearance due to the suppression of the change of the color of a formulation over time.SOLUTION: The oral composition of the present invention is characterized by containing: (A) tranexamic acid; (B) an aluminium compound selected from potassium aluminum sulfate, aluminium ammonium sulfate, and aluminium sulfate; and (C) tea extract.SELECTED DRAWING: None

Description

  The present invention relates to a tranexamic acid-containing composition for oral cavity that has an excellent hemostatic effect, and is capable of suppressing discoloration of the preparation over time and having good appearance stability.

In recent years, with the improvement of prevention awareness of periodontal disease, there is an increasing need for oral care products that are a category of periodontal disease care. In particular, bleeding from the gums associated with periodontal disease is present in, for example, a discharge product after brushing and is easily recognized visually, so an oral care product having a hemostatic effect is required.
As effective means for preventing or improving bleeding from such gums, it is known that hemostatic agents and anti-inflammatory agents are effective, and gum tightening is known to be useful. Giving a sense of effectiveness is important in terms of enhancing the intention to use, improving effectiveness, and making habits.

Tranexamic acid is known as a component having a hemostatic action for the oral cavity. However, tranexamic acid may be deteriorated in stability over time depending on the composition, resulting in a discoloration of the preparation (Patent Document 1; Japanese Patent No. 4656299).
On the other hand, an astringent feeling is effective for tightening gums, and it is known that an aluminum compound typified by alum such as aluminum potassium sulfate has an astringent action and a hemostatic action.
In Patent Documents 2 and 3 (International Publication No. 2009/034919, JP-A-2006-155791), a dentifrice with improved astringency by using sodium compound or highly polymerized polyethylene glycol in combination with an aluminum compound such as potassium aluminum sulfate. A composition is proposed, but it is unclear because it does not mention hemostasis or its effect.

Japanese Patent No. 4656299 International Publication No. 2009/034919 JP 2006-155791 A Japanese Patent Laid-Open No. 11-222419 JP 2008-143870 A

  However, the conventional technique has not been able to satisfactorily give an effect feeling (hemostatic effect feeling) due to hemostasis of the gums.

  The present invention has been made in view of the above circumstances, and provides a composition for oral cavity that provides a hemostatic effect that has both excellent hemostatic effect and astringent feeling, and has good appearance stability because discoloration of the preparation is suppressed over time. The purpose is to do.

  As a result of intensive studies to achieve the above-mentioned object, the present inventor has found that the oral composition is combined with tranexamic acid and a specific aluminum compound, and further combined with a tea extract to provide an excellent hemostatic effect and a sense of convergence. It has been found that a hemostatic effect can be realized, and the discoloration of the preparation can be suppressed over time to maintain the appearance stability, and the present invention has been made.

In the present invention, (A) tranexamic acid, (B) an aluminum compound selected from potassium aluminum sulfate, aluminum ammonium sulfate, and aluminum sulfate, and (C) a tea extract, in combination of the three, (A) And the combined system of component (B) gives a high hemostatic effect to the gums (actual feeling that blood is not mixed in the discharged product after use) and a convergence, and (C) component (A) and ( B) Formulation discoloration caused by the combined use of the components is suppressed even over time, and the formulation appearance is stabilized.
More specifically, as will be apparent from the comparative examples described later, the present inventors, together with tranexamic acid that has a hemostatic action effective in suppressing bleeding of gums and the like, together with an aluminum compound such as alum having a converging action, Although the hemostatic effect and astringent feeling were improved, the formulation was discolored over time, resulting in poor formulation stability (Comparative Example 3). Therefore, as a result of further investigations to solve the problem relating to the discoloration, when the (C) component is combined with the (A) and (B) components, the (C) component unexpectedly acts as a discoloration inhibitor, Discoloration caused by the combined use of the components (A) and (B) was also suppressed over time, and the preparation could be stabilized. Moreover, such discoloration suppression is not obtained when using a licorice extract, which is a plant extract having an antioxidative effect similar to that of the tea extract (Comparative Example 4), and is an action specific to the component (C). It was. Furthermore, in this case, when the component (C) is used in combination with the component (A) without blending the component (B), the hemostatic effect is lowered (Comparative Example 2), and the component (A) is blended. In contrast, when the component (B) was used in combination with the component (B), the astringent action was improved, but almost no hemostatic effect was observed (Comparative Example 1). However, when the components (A), (B), and (C) were combined, it was possible to achieve both an excellent hemostatic effect and a convergent feeling as described above. Thereby, as apparent from the examples described later, the above-described special effects can be imparted by the combination of the components (A), (B), and (C).

  In Patent Documents 4 and 5 (Japanese Patent Laid-Open Nos. 11-222419 and 2008-143870), tranexamic acid and further tea extract and extract are blended in the oral composition. Is improvement of the bitterness of tannin contained in tea extract and the like by licorice extract, and Patent Document 5 is an improvement in intention of use that does not get tired even if it is continuously used by a component having bitterness such as ryokucha extract. .

Accordingly, the present invention provides the following oral composition.
[1]
(A) tranexamic acid,
(B) An oral composition comprising an aluminum compound selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate, and (C) tea extract.
[2]
(A) 0.002 to 1% by mass of component, (B) component to 0.2 to 3% by mass, (C) component as 0.001 to 1% by mass as pure extract Oral composition.
[3]
[(A) + (B)] / (C) is an oral composition as described in [1] or [2] whose mass ratio is 1-1500.
[4]
The composition for oral cavity according to any one of [1] to [3], which is a toothpaste.

  ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which gives the outstanding hemostatic effect actual feeling which has a hemostatic effect feeling and an astringent feeling, and the discoloration of a formulation is suppressed also with time and favorable external appearance stability can be provided. This composition for oral cavity is suitable for prevention or improvement of bleeding in the oral cavity such as gums.

The present invention will be described in further detail below. The composition for oral cavity of the present invention comprises (A) tranexamic acid,
(B) An aluminum compound selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate, and (C) a tea extract.

(A) Tranexamic acid has a hemostatic action (antiplasmin action) and gives a feeling of hemostatic effect. Specifically, commercially available products such as tranexamic acid (Daiichi Pharmatech Co., Ltd.) can be used.
(A) The amount of tranexamic acid is preferably 0.002 to 1% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.005 to 0.5%, and still more preferably 0.01 to 0. .1%. When the blending amount is 0.002% or more, a sufficient hemostatic effect is obtained. When it is 1% or less, the appearance (discoloration) stability of the preparation can be sufficiently maintained.

The component (B) is an aluminum compound selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate, and these have a convergent action. As the component (B), one of these may be used alone or in combination of two or more thereof. From the viewpoint of feeling of use, among them, double salt aluminum potassium sulfate, aluminum ammonium sulfate, particularly aluminum potassium sulfate may be used. preferable.
Specifically, potassium aluminum sulfate (manufactured by Daimei Chemical Industry Co., Ltd., Kari Alum (hydrate)), ammonium ammonium sulfate (manufactured by Daimei Chemical Industry Co., Ltd., ammonium alum), aluminum sulfate (Daimei Chemical Industry Co., Ltd.) )) And other commercial products can be used.

  (B) The compounding quantity of the aluminum compound of a component has preferable 0.2 to 3% of the whole composition, More preferably, it is 0.3 to 2%. When the blending amount is 0.2% or more, the convergence property is sufficiently exhibited and the hemostatic effect is improved. When it is 3% or less, the appearance (discoloration) stability of the preparation can be sufficiently maintained. In addition, when it exceeds 3%, formulation stability (liquid separation) may be impaired or irritation may become strong.

(C) The tea extract acts as a discoloration inhibitor when combined with the combined system of the components (A) and (B), and also acts as an astringency improver.
As the tea extract, a commercially available product or one obtained by a known method can be used.
Specifically, the raw material is green tea. As the extraction solvent, a hydrophilic solvent can be used, and examples thereof include water, lower monohydric alcohols such as ethanol and propanol, polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, and the like. A solvent or two or more mixed solvents can be used. Ordinary methods can be employed for extraction conditions and post-treatment. Examples of commercially available products include green tea extract (manufactured by Maruzen Pharmaceutical Co., Ltd.).

  (C) The blending amount of the tea extract is preferably 0.001 to 1%, more preferably 0.005 to 1%, and still more preferably 0.01 to 0.00% of the whole composition as a pure extract excluding the solvent. 5%. As the blending amount increases, the discoloration suppressing action and the astringency improving action increase, and when it is 0.001% or more, the appearance (discoloration) stability and the astringent feeling of the preparation are sufficiently excellent. If the amount is too large, bitterness may be felt, and liquid separation may occur and the stability of the preparation may be impaired. If the amount is 1% or less, the appearance stability of the preparation is prevented by preventing the occurrence of bitterness by itself. Can be maintained sufficiently.

  (C) [(A) + (B)] / (C) indicating the ratio of the total blending amount of (A) tranexamic acid and (B) specific aluminum compound to the blending amount of the tea extract is 1, 500 or less is preferable, 1,050 or less is more preferable, 500 or less is further preferable, 250 or less is particularly preferable, and 25 or less is particularly preferable. If the ratio is too large, discoloration may not be sufficiently suppressed, but if it is 1,500 or less, discoloration is suppressed and the appearance stability of the preparation is further improved. The lower limit of the ratio is not particularly limited, but is preferably 1 or more. If the ratio is too small, the ratios of the components (A) and (B) are relatively reduced, so that the hemostatic effect and the convergence feeling may be lowered.

  The composition for oral cavity of the present invention can be prepared as a toothpaste such as a toothpaste, a liquid toothpaste, and a toothpaste, a mouthwash or the like. Further, depending on the dosage form, other known additives can be blended as optional components in addition to the essential components as long as the effects of the present invention are not hindered. For example, in the case of toothpaste, abrasives, thickeners, binders, surfactants, and sweeteners, preservatives, active ingredients, colorants, fragrances, and the like can be blended as necessary. Can be mixed by a conventional method.

  As abrasives, silica-based abrasives such as anhydrous silicic acid, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate, anhydrous calcium phosphate, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate , Calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate , Hydroxyapatite, fluoroapatite, calcium deficient apatite, synthetic resin-based abrasive and the like (the amount is usually 2 to 50%, particularly 10 to 40%).

  Examples of thickeners include glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000 (average molecular weight described in Quasi-drug Raw Material Standard 2006, the same applies hereinafter), ethylene glycol, reduced starch saccharified product, and the like. One type or two or more types such as a monohydric alcohol can be used (the amount is usually 5 to 70%).

  As binder, organic binders such as sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, carboxymethylcellulose sodium, hydroxyethylcellulose, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin, bentonite, etc. Examples thereof include inorganic binders (the amount is usually 0 to 10%).

  As the surfactant, as an anionic surfactant, for example, sodium lauryl sulfate, lauroyl sarcosine sodium, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, α-olefin sulfonate, etc. Nonionic surfactants such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, coconut oil fatty acid amidopropyl betaine, such as alkyl glycoside, sucrose fatty acid ester, alkylol amide , Polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, decaglyceryl laurate, polyoxyethylene hydrogenated castor oil, etc. It is (the amount is usually 0.1 to 5%).

  Sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, and perilartin. Sodium etc. are mentioned.

  As active ingredients, other than the components (A) and (B), for example, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, normal phosphoric acid Water-soluble phosphate compounds such as potassium salt, sodium salt, epsilon-aminocaproic acid, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, glycyrrhetin, glycyrrhetic acid , Copper phosphate compounds such as copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper compounds such as copper gluconate, strontium chloride, potassium nitrate, hydroxamic acid or its derivatives, sodium tripolyphosphate Um, zeolite, methoxyethylene, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, zinc oxide, Japanese cinnamon extract, buckwheat extract, chamomile, clove, rosemary, hornon, safflower, etc. A plant extract etc. are mentioned. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances that have been processed (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and Menthol, Carvone, Anethole, Cineol, Methyl salicylate , Synamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde , Citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl Alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacete For peroral compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The well-known perfume material used can be used.

  The blending amount of the fragrance is not particularly limited, but the above fragrance material is preferably used in the composition in an amount of 0.000001 to 1%. Moreover, it is preferable to use 0.1-2.0% of the fragrance | flavor for perfume using the said fragrance | flavor raw material in a composition.

  Examples of the colorant include blue No. 1, yellow No. 4, green No. 3, and the like.

  The material in particular of the container which accommodates the composition for oral cavity of this invention is not restrict | limited, Usually, the container used for the composition for oral cavity can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. Moreover, the compounding quantity of a tea extract is an extract pure content. The “pure extract amount” is a pure amount of the extract excluding the extraction solvent.

[Examples and Comparative Examples]
Dentifrice compositions (toothpastes) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in the table.

(1) Appearance (discoloration) stability evaluation method of the formulation The appearance immediately after production of the dentifrice composition and the appearance after storage for 1 month in a 60 ° C. environment are visually confirmed, and the degree of discoloration is evaluated as follows. Evaluation was based on criteria.
·Evaluation criteria:
A: No change in color immediately after manufacture, 1 month storage, no problem B: No change in color immediately after manufacture, slight color change observed in 1 month storage, but no problem C: Immediately after manufacture There is no discoloration of the product, but there is a clear discoloration in the product that has been stored for one month, and there is a problem level D: The product immediately after production is browned and there is a problem

(2) Evaluation method of convergence feeling Sensory evaluation was performed using 10 specialized panelists as subjects. The dentifrice composition filled in the laminate tube was extruded by 1 cm onto a toothbrush, and brushed for 3 minutes in the same manner as usual, and the astringent feeling during use was judged according to the following criteria.
・ Score criteria:
4 points: A feeling of convergence is fully felt 3 points: A feeling of convergence is felt 2 points: A feeling of convergence is weak 1 point: A feeling of convergence is not felt A value obtained by averaging the results of 10 professional panelists was obtained and evaluated according to the following evaluation criteria . Those with an evaluation of ◎ and ○ were judged to be acceptable because they felt astringency during use.
·Evaluation criteria:
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

(3) Method for evaluating the effect of hemostasis Evaluation was performed using 10 subjects who were aware of the symptoms of blood mixing in the foam exhaled when brushing their teeth. The dentifrice composition filled in the laminate tube was extruded 1 cm onto a toothbrush and mounted for 3 minutes with the same method as usual, and the hemostatic effect was determined according to the following criteria.
Here, the “feeling of hemostasis effect” is a feeling that the degree of blood mixing in the discharged foam has been improved.
・ Score criteria:
4 points: I feel a very strong hemostatic effect 3 points: I feel a hemostatic effect 2 points: I don't feel a hemostatic effect very much 1 point: I don't feel a hemostatic effect at all Find the average value of the results of 10 professional panelists Evaluation was performed according to the following evaluation criteria. Those for which evaluations of ◎ and ○ were ensured were judged to be acceptable because a hemostatic effect was felt.
·Evaluation criteria:
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

＊；チャエキス；緑茶抽出物（丸善製薬（株）製）、配合量はエキス純分量（以下同様）。

*: Cha extract; green tea extract (manufactured by Maruzen Pharmaceutical Co., Ltd.).

  The toothpaste compositions of the formulation examples shown below were prepared and evaluated in the same manner as in the examples. As a result, the appearance (discoloration) stability, the convergence feeling and the hemostatic effect were all excellent. In addition, the tea extract used the thing similar to an Example, The compounding quantity is the extract pure part quantity except the extraction solvent.

[Prescription Example 1]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 20
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Saccharin sodium 0.2
Sodium fluoride 0.32
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 2]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 20
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Saccharin sodium 0.2
Sodium fluoride 0.11
Sodium monofluorophosphate 0.38
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 3]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 20
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Saccharin sodium 0.2
Sodium monofluorophosphate 0.76
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 4]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 20
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Saccharin sodium 0.2
Sodium monofluorophosphate 1.1
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 5]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 20
Silicic anhydride 15
Propylene glycol 5
Sodium carboxymethylcellulose 1
Xanthan gum 0.5
Sodium lauryl sulfate 1
Saccharin sodium 0.05
Sodium fluoride 0.22
Vitamin E 0.1
Sodium benzoate 0.5
Butylparaben 0.01
Titanium oxide 0.1
Blue No. 1 0.0005
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 6]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 25
Silicic anhydride 15
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium alginate 0.5
Sodium lauryl sulfate 1.5
Saccharin sodium 0.1
Sodium fluoride 0.22
Dipotassium glycyrrhizinate 0.1
Vitamin E 0.5
Isopropylmethylphenol 0.1
Methylparaben 0.1
Titanium oxide 0.1
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 7]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.001
Sorbit liquid (70% Sorbit) 30
Silicic anhydride 20
Polyethylene glycol 400 5
Xanthan gum 1
Sodium alginate 0.5
Sodium lauryl sulfate 2
Saccharin sodium 0.15
Sodium fluoride 0.22
Sodium benzoate 0.5
Butylparaben 0.01
Titanium oxide 0.5
Green No. 3 0.002
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 1,050

[Prescription Example 8]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.005
Sorbit liquid (70% Sorbit) 35
Silicic anhydride 20
Polyethylene glycol 400 5
Xanthan gum 1
Sodium polyacrylate 0.5
Sodium lauryl sulfate 2.5
Saccharin sodium 0.2
Sodium fluoride 0.22
Dipotassium glycyrrhizinate 0.1
Isopropylmethylphenol 0.1
Methylparaben 0.1
Butylparaben 0.01
Titanium oxide 0.5
Blue No. 1 0.0005
Yellow No. 4 0.0001
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 210

[Prescription Example 9]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.01
Sorbit liquid (70% Sorbit) 40
Silicic anhydride 25
Polyethylene glycol 400 5
Sodium alginate 1
Sodium polyacrylate 0.5
Sodium lauryl sulfate 3
Saccharin sodium 0.25
Sodium fluoride 0.22
Sodium benzoate 0.5
Titanium oxide 1
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 105

[Prescription Example 10]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.05
Sorbit liquid (70% Sorbit) 45
Silicic anhydride 25
Polyethylene glycol 400 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Palm oil fatty acid amidopropyl betaine 0.1
Saccharin sodium 0.3
Sodium monofluorophosphate 0.76
Dipotassium glycyrrhizinate 0.1
Isopropylmethylphenol 0.1
Methylparaben 0.1
Titanium oxide 1
Blue No. 1 0.001
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 21

[Prescription Example 11]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.1
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 30
Propylene glycol 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Polyoxyethylene hydrogenated castor oil 0.2
Saccharin sodium 0.1
Sodium monofluorophosphate 0.76
Vitamin E 0.1
Sodium benzoate 0.5
Butylparaben 0.01
Blue No. 1 0.0005
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 10.5

[Prescription Example 12]
(A) Tranexamic acid 0.05%
(B) Potassium aluminum sulfate 1
(C) Cha extract 0.5
Sorbit liquid (70% Sorbit) 50
Silicic anhydride 30
Polyethylene glycol 400 5
Sodium carboxymethylcellulose 1
Sodium lauryl sulfate 2
Palm oil fatty acid amidopropyl betaine 0.2
Polyoxyethylene hydrogenated castor oil 0.1
Saccharin sodium 0.2
Sodium monofluorophosphate 0.76
Dipotassium glycyrrhizinate 0.1
Isopropylmethylphenol 0.1
Methylparaben 0.1
Butylparaben 0.01
Blue No. 1 0.001
Green No. 3 0.003
Fragrance 1
Purified water balance
Total 100%
[(A) + (B)] / (C) = 2.1

Claims (4)

(A) tranexamic acid,
(B) An oral composition comprising an aluminum compound selected from potassium aluminum sulfate, aluminum ammonium sulfate and aluminum sulfate, and (C) tea extract.   The component (A) is 0.002 to 1% by mass, the component (B) is 0.2 to 3% by mass, and the component (C) is 0.001 to 1% by mass as a pure extract. Oral composition.   The composition for oral cavity according to claim 1 or 2, wherein [(A) + (B)] / (C) is 1-1500 as a mass ratio.   It is a toothpaste, The composition for oral cavity of any one of Claims 1-3.