JP7447470B2 - dentifrice composition - Google Patents
dentifrice composition Download PDFInfo
- Publication number
- JP7447470B2 JP7447470B2 JP2019229443A JP2019229443A JP7447470B2 JP 7447470 B2 JP7447470 B2 JP 7447470B2 JP 2019229443 A JP2019229443 A JP 2019229443A JP 2019229443 A JP2019229443 A JP 2019229443A JP 7447470 B2 JP7447470 B2 JP 7447470B2
- Authority
- JP
- Japan
- Prior art keywords
- dentifrice composition
- fluoride
- fluorine
- calcium
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 67
- 239000000551 dentifrice Substances 0.000 title claims description 44
- 229920002678 cellulose Polymers 0.000 claims description 17
- 239000001913 cellulose Substances 0.000 claims description 17
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- 159000000007 calcium salts Chemical class 0.000 claims description 11
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 229940034610 toothpaste Drugs 0.000 claims description 8
- 239000000606 toothpaste Substances 0.000 claims description 8
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 235000011180 diphosphates Nutrition 0.000 claims description 5
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 4
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- -1 fluoride ions Chemical class 0.000 description 55
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 41
- 230000014759 maintenance of location Effects 0.000 description 37
- 229910052731 fluorine Inorganic materials 0.000 description 25
- 239000011737 fluorine Substances 0.000 description 25
- 238000000926 separation method Methods 0.000 description 24
- 239000007788 liquid Substances 0.000 description 23
- 210000000214 mouth Anatomy 0.000 description 22
- 238000007711 solidification Methods 0.000 description 21
- 230000008023 solidification Effects 0.000 description 21
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 210000002200 mouth mucosa Anatomy 0.000 description 11
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 239000011230 binding agent Substances 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 7
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 229910001634 calcium fluoride Inorganic materials 0.000 description 6
- 238000005227 gel permeation chromatography Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000000717 retained effect Effects 0.000 description 6
- 239000000377 silicon dioxide Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 229940083542 sodium Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 229920000388 Polyphosphate Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical class C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 239000001205 polyphosphate Substances 0.000 description 3
- 235000011176 polyphosphates Nutrition 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229940048084 pyrophosphate Drugs 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- CFAKWWQIUFSQFU-UHFFFAOYSA-N 2-hydroxy-3-methylcyclopent-2-en-1-one Chemical compound CC1=C(O)C(=O)CC1 CFAKWWQIUFSQFU-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 2
- 239000001362 calcium malate Substances 0.000 description 2
- 229940016114 calcium malate Drugs 0.000 description 2
- 235000011038 calcium malates Nutrition 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005115 demineralization Methods 0.000 description 2
- 230000002328 demineralizing effect Effects 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- GQOKIYDTHHZSCJ-UHFFFAOYSA-M dimethyl-bis(prop-2-enyl)azanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC=C GQOKIYDTHHZSCJ-UHFFFAOYSA-M 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000013022 formulation composition Substances 0.000 description 2
- 239000008369 fruit flavor Substances 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 2
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- IAEGWXHKWJGQAZ-UHFFFAOYSA-N trimethylpyrazine Chemical compound CC1=CN=C(C)C(C)=N1 IAEGWXHKWJGQAZ-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
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- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- HNAGHMKIPMKKBB-UHFFFAOYSA-N 1-benzylpyrrolidine-3-carboxamide Chemical compound C1C(C(=O)N)CCN1CC1=CC=CC=C1 HNAGHMKIPMKKBB-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- MVOSYKNQRRHGKX-UHFFFAOYSA-N 11-Undecanolactone Chemical compound O=C1CCCCCCCCCCO1 MVOSYKNQRRHGKX-UHFFFAOYSA-N 0.000 description 1
- RWYRUDPAALLKPX-UHFFFAOYSA-N 2,2-difluoro-n-methylethanamine;hydrochloride Chemical compound Cl.CNCC(F)F RWYRUDPAALLKPX-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- GNCOVOVCHIHPHP-UHFFFAOYSA-N 2-[[4-[4-[(1-anilino-1,3-dioxobutan-2-yl)diazenyl]-3-chlorophenyl]-2-chlorophenyl]diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC(C(=C1)Cl)=CC=C1C(C=C1Cl)=CC=C1N=NC(C(C)=O)C(=O)NC1=CC=CC=C1 GNCOVOVCHIHPHP-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 description 1
- 239000001837 2-hydroxy-3-methylcyclopent-2-en-1-one Substances 0.000 description 1
- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 description 1
- MDVYIGJINBYKOM-UHFFFAOYSA-N 3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]-1,2-propanediol Chemical compound CC(C)C1CCC(C)CC1OCC(O)CO MDVYIGJINBYKOM-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- AXCXHFKZHDEKTP-NSCUHMNNSA-N 4-methoxycinnamaldehyde Chemical compound COC1=CC=C(\C=C\C=O)C=C1 AXCXHFKZHDEKTP-NSCUHMNNSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- TWXUTZNBHUWMKJ-UHFFFAOYSA-N Allyl cyclohexylpropionate Chemical compound C=CCOC(=O)CCC1CCCCC1 TWXUTZNBHUWMKJ-UHFFFAOYSA-N 0.000 description 1
- WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
本発明は、口腔内、特に口腔粘膜へのフッ素イオンの滞留性に優れ、かつその放出性にも優れるフッ素化合物含有の歯磨剤組成物に関する。 The present invention relates to a fluorine compound-containing dentifrice composition that has excellent retention of fluoride ions in the oral cavity, particularly in the oral mucosa, and also has excellent release properties.
フッ化ナトリウム等のフッ素含有化合物は、再石灰化促進や脱灰抑制等の機能を有する薬用成分として、う蝕予防等の目的で歯磨剤組成物等の口腔用組成物に広く用いられている。フッ素含有化合物を効果的に作用させるには、フッ素イオンを長時間に亘って口腔内の歯面に滞留させることが有効であり、また、使用後に口腔内をうがいして水で漱ぐなどした後でも口腔内にフッ素イオンを多く残して留めておくことも重要であるが、特に歯磨剤組成物はブラッシング後の漱ぎによって洗い流されるため、口腔内に残存するフッ素イオンは微量に過ぎなかった。 Fluorine-containing compounds such as sodium fluoride are widely used in oral compositions such as dentifrice compositions for purposes such as caries prevention as medicinal ingredients that have functions such as promoting remineralization and inhibiting demineralization. . In order for fluorine-containing compounds to work effectively, it is effective to allow fluoride ions to remain on the tooth surfaces in the oral cavity for a long period of time, and it is also effective to gargle and rinse the oral cavity with water after use. It is also important to keep a large amount of fluoride ions in the oral cavity even after brushing, but since dentifrice compositions are washed away by rinsing after brushing, only a small amount of fluoride ions remain in the oral cavity.
歯磨剤組成物に配合したフッ素イオンの口腔内滞留性を向上させるために、再石灰化成分であるカルシウムイオン、フッ素イオンを共存させる方法があるが、カルシウムイオンとフッ素イオンは反応性が高く、共存させると歯牙に対して作用する以前に不溶性物質であるフッ化カルシウムとなり、十分な効果を発揮させることができなかった。また、特許文献1(特表平10-511956号公報)では、カルシウムイオンとフッ素イオンを口腔内で又は口腔への適用直前に当該2つの組成物を混合することにより、口腔内でフッ化カルシウムを生成させる形態の口腔用剤が提案されているが、この方法では、フッ素イオンとして口腔内に入るため、すぐに唾液で流され、十分な滞留効果が発揮されず、また、2成分混合後に短時間でフッ化カルシウムが析出するため、フッ素イオンが十分に放出されず再石灰化予防効果が満足に発揮されなかった。特許文献2(特開2009-137863号公報)には、ポリリン酸塩、カルシウム塩、フッ化物塩の複合体を予め調製した組成物が提案されているが、この方法では調製面での煩雑さや歯磨製剤としての長期保存後に液状化や固化するなどの課題があった。
また、特許文献3~5(特開2015-117215号公報、特開2013-67567号公報、特開2007-320894号公報)には、歯磨剤組成物において、特定のカチオン性高分子物質を用いた、歯面にフッ素イオンを吸着・滞留させる方法が提案されているが、その滞留性やブラッシング後の残存量には未だ改善の余地があり、更なる滞留性の向上が望まれた。
In order to improve the retention of fluoride ions in a dentifrice composition in the oral cavity, there is a method of coexisting calcium ions and fluoride ions, which are remineralizing components, but calcium ions and fluoride ions are highly reactive; If they coexist, calcium fluoride becomes an insoluble substance before acting on the teeth, and the sufficient effect cannot be achieved. Moreover, in Patent Document 1 (Japanese Patent Application Publication No. 10-511956), calcium fluoride ions and fluoride ions are mixed in the oral cavity or immediately before application to the oral cavity, and calcium fluoride is added to the oral cavity. Oral preparations have been proposed that generate Since calcium fluoride was precipitated in a short period of time, fluoride ions were not sufficiently released and the remineralization prevention effect was not satisfactorily exhibited. Patent Document 2 (Japanese Unexamined Patent Publication No. 2009-137863) proposes a composition in which a complex of a polyphosphate, a calcium salt, and a fluoride salt is prepared in advance, but this method is complicated and difficult to prepare. There were problems such as liquefaction and solidification after long-term storage as a toothpaste preparation.
Furthermore, Patent Documents 3 to 5 (Japanese Unexamined Patent Application Publications No. 2015-117215, 2013-67567, and 2007-320894) disclose that specific cationic polymer substances are used in dentifrice compositions. A method of adsorbing and retaining fluoride ions on tooth surfaces has been proposed, but there is still room for improvement in the retention properties and the amount remaining after brushing, and further improvement in retention properties has been desired.
本発明は、上記事情に鑑みなされたもので、口腔内、特に口腔粘膜へのフッ素イオンの滞留性に優れ、その放出性にも優れる歯磨剤組成物を提供することを目的とする。 The present invention was made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition that has excellent retention of fluoride ions in the oral cavity, particularly in the oral mucosa, and also has excellent release properties.
本発明者らは、上記目的を達成するため鋭意検討を行った結果、フッ化ナトリウムに、特定のポリリン酸塩及び水溶性カルシウム塩をそれぞれ特定量で併用し、更にカチオン化セルロースを組み合わせて歯磨剤組成物に配合すると、口腔内、特に口腔粘膜へのフッ素イオンの滞留性に優れ、フッ素イオンが高率で口腔内に滞留し、しかも、フッ素イオンの放出性(放出量、徐放性)に優れ、滞留したフッ素イオンが徐放し、長時間口腔内にフッ素イオンを供給でき、また、長期保存後も液分離及び固化が抑制され、良好な保存安定性となることを知見した。即ち、本発明では、(A)トリポリリン酸塩及びピロリン酸塩から選ばれる1種以上を0.1~1.5質量%、(B)水溶性カルシウム塩を0.1~1.5質量%、(C)フッ化ナトリウム、及び(D)カチオン化セルロースを配合した歯磨剤組成物が、口腔内、特に口腔粘膜へのフッ素イオンの滞留性に優れ、その放出性にも優れ、また、液分離安定性及び固化安定性を有し保存安定性も良いことを知見し、本発明をなすに至った。 As a result of intensive studies to achieve the above object, the present inventors have found that sodium fluoride, a specific polyphosphate and a water-soluble calcium salt are used together in specific amounts, and cationized cellulose is also used in toothpaste. When incorporated into a drug composition, it has excellent retention of fluoride ions in the oral cavity, especially in the oral mucosa, and retains a high percentage of fluoride ions in the oral cavity. It has been found that the fluoride ions have excellent storage stability, allowing sustained release of fluoride ions and supplying fluoride ions into the oral cavity for a long period of time.Also, liquid separation and solidification are suppressed even after long-term storage, resulting in good storage stability. That is, in the present invention, (A) 0.1 to 1.5% by mass of one or more selected from tripolyphosphate and pyrophosphate, and (B) 0.1 to 1.5% by mass of water-soluble calcium salt. , (C) sodium fluoride, and (D) cationized cellulose. It was discovered that it has separation stability and solidification stability, and also good storage stability, and the present invention was completed based on this finding.
歯磨剤組成物に配合されたフッ素含有化合物のフッ素が、歯面だけでなく口腔粘膜にも十分に滞留すれば口腔内滞留性がより高まると期待されたが、口腔粘膜はムチン等の唾液タンパクで覆われているためにフッ素が吸着し難く、従来の技術では口腔粘膜にフッ素を十分に滞留させることができなかった。しかし、本発明では、(C)成分に、(A)及び(B)成分を併用し、かつ(D)成分を組み合わせることで、(A)成分量と(B)成分量とが特定範囲内で、(D)成分によって(C)成分由来のフッ素イオンの口腔粘膜への滞留性が改善し、フッ素イオンの滞留性だけでなくその放出性も優れたものとすることができた。この場合、(D)成分によって、口腔粘膜を覆っているムチンへのフッ素イオンの吸着性が高まることでその滞留性が改善し、フッ素イオンが高率で口腔粘膜に滞留し、しかも、滞留したフッ素イオンが徐々に唾液中に放出され、唾液と接する歯面に長時間供給される。したがって、本発明の歯磨剤組成物によれば、液分離安定性及び固化安定性を確保してフッ素イオンの口腔内滞留性を向上できる。 It was expected that if the fluoride contained in the fluorine-containing compound contained in the dentifrice composition was sufficiently retained not only on the tooth surface but also in the oral mucosa, the retention in the oral cavity would be further improved. This makes it difficult for fluoride to adsorb, and conventional techniques have not been able to sufficiently retain fluoride in the oral mucosa. However, in the present invention, by using the (A) and (B) components together with the (C) component and also combining the (D) component, the amount of the component (A) and the amount of the component (B) are within a specific range. Component (D) improved the retention of fluoride ions derived from component (C) in the oral mucosa, making it possible to improve not only the retention of fluoride ions but also their release. In this case, component (D) improves the retention of fluoride ions by increasing their adsorption to the mucin covering the oral mucosa, resulting in a high rate of fluoride ions staying in the oral mucosa, and Fluoride ions are gradually released into saliva and are supplied to tooth surfaces in contact with saliva for a long time. Therefore, according to the dentifrice composition of the present invention, it is possible to ensure liquid separation stability and solidification stability and improve the retention of fluorine ions in the oral cavity.
後述の比較例に示すように、(A)、(B)及び(C)成分が配合され、(D)成分が配合されていないと、フッ素(フッ素イオン)滞留性及びフッ素放出性、製剤の液分離安定性が悪く(比較例5)、また、(D)成分が配合されていても、(A)成分量又は(B)成分量が不適切であると、フッ素滞留性及びフッ素放出性が悪かった(比較例1~4)。これに対して、本発明の特定量の(A)及び(B)成分、(C)成分、(D)成分が配合された歯磨剤組成物(後述の実施例)は、フッ素滞留性及びフッ素放出性が優れ、製剤の液分離安定性(保存後の液分離のなさ)及び固化安定性(保存後の固化のなさ)が良好であった。 As shown in the comparative example below, when components (A), (B), and (C) are blended, but component (D) is not blended, the fluorine (fluoride ion) retention and fluorine release properties of the preparation are Liquid separation stability is poor (Comparative Example 5), and even if component (D) is blended, if the amount of component (A) or component (B) is inappropriate, fluorine retention and fluorine release properties may be impaired. were poor (Comparative Examples 1 to 4). On the other hand, the dentifrice composition of the present invention containing specific amounts of components (A) and (B), components (C), and components (D) (examples described below) has excellent fluoride retention and fluorine The release property was excellent, and the liquid separation stability (no liquid separation after storage) and solidification stability (no solidification after storage) of the formulation were good.
従って、本発明は、下記の歯磨剤組成物を提供する。
〔1〕
(A)トリポリリン酸塩及びピロリン酸塩から選ばれる1種以上を0.1~1.5質量%、
(B)水溶性カルシウム塩を0.1~1.5質量%、
(C)フッ化ナトリウム
及び
(D)カチオン化セルロース
を含有することを特徴とする歯磨剤組成物。
〔2〕
(A)成分が、ピロリン酸カリウムである〔1〕に記載の歯磨剤組成物。
〔3〕
(B)水溶性カルシウム塩が、塩化カルシウムである〔1〕又は〔2〕に記載の歯磨剤組成物。
〔4〕
(A)/(C)が、モル比として0.05~1である〔1〕~〔3〕のいずれかに記載の歯磨剤組成物。
〔5〕
(B)/(C)が、モル比として0.1~2である〔1〕~〔4〕のいずれかに記載の歯磨剤組成物。
〔6〕
(C)成分の含有量が0.11~1.1質量%である〔1〕~〔5〕のいずれかに記載の歯磨剤組成物。
〔7〕
(D)成分の含有量が0.01~0.5質量%である〔1〕~〔6〕のいずれかに記載の歯磨剤組成物。
〔8〕
練歯磨剤組成物である〔1〕~〔7〕のいずれかに記載の歯磨剤組成物。
Therefore, the present invention provides the following dentifrice composition.
[1]
(A) 0.1 to 1.5% by mass of one or more selected from tripolyphosphate and pyrophosphate;
(B) 0.1 to 1.5% by mass of water-soluble calcium salt;
A dentifrice composition comprising (C) sodium fluoride and (D) cationized cellulose.
[2]
The dentifrice composition according to [1], wherein the component (A) is potassium pyrophosphate.
[3]
(B) The dentifrice composition according to [1] or [2], wherein the water-soluble calcium salt is calcium chloride.
[4]
The dentifrice composition according to any one of [1] to [3], wherein (A)/(C) is a molar ratio of 0.05 to 1.
[5]
The dentifrice composition according to any one of [1] to [4], wherein (B)/(C) is a molar ratio of 0.1 to 2.
[6]
The dentifrice composition according to any one of [1] to [5], wherein the content of component (C) is 0.11 to 1.1% by mass.
[7]
The dentifrice composition according to any one of [1] to [6], wherein the content of component (D) is 0.01 to 0.5% by mass.
[8]
The dentifrice composition according to any one of [1] to [7], which is a dentifrice composition.
本発明によれば、口腔内、特に口腔粘膜へのフッ素イオンの滞留性に優れ、その放出性にも優れ、また、液分離安定性及び固化安定性を有し保存安定性も良い歯磨剤組成物を提供できる。本発明の歯磨剤組成物は、口腔内をブラッシング後にうがいして水で漱いだ後でもフッ素イオンを比較的多く口腔内に残して留めておくことができ、フッ素含有化合物の再石灰化促進、脱灰抑制等の効果を十分に発揮させることもでき、う蝕予防用として好適である。 According to the present invention, a dentifrice composition has excellent retention of fluoride ions in the oral cavity, especially the oral mucosa, and excellent release properties, and also has liquid separation stability, solidification stability, and storage stability. I can provide things. The dentifrice composition of the present invention can retain a relatively large amount of fluoride ions in the oral cavity even after gargling and rinsing the oral cavity with water, promoting remineralization of fluorine-containing compounds. It is also possible to fully exhibit effects such as suppressing demineralization, and is suitable for caries prevention.
以下、本発明につき更に詳述する。本発明の歯磨剤組成物は、(A)トリポリリン酸塩及びピロリン酸塩から選ばれる1種以上、(B)水溶性カルシウム塩、(C)フッ化ナトリウム、及び(D)カチオン化セルロースを含有する。 The present invention will be explained in more detail below. The dentifrice composition of the present invention contains (A) one or more selected from tripolyphosphates and pyrophosphates, (B) a water-soluble calcium salt, (C) sodium fluoride, and (D) cationized cellulose. do.
(A)成分は、ポリリン酸塩のトリポリリン酸塩、ピロリン酸塩である。(A)成分は、フッ素イオンの滞留性の向上作用を奏し、また、液分離抑制作用を奏する。
(A)成分は、トリポリリン酸、ピロリン酸のカリウム塩、ナトリウム塩等のアルカリ金属塩を使用でき、中でもピロリン酸カリウムが好ましい。これらは1種単独でも2種以上を併用してもよい。
Component (A) is a polyphosphate tripolyphosphate or pyrophosphate. Component (A) has the effect of improving the retention of fluorine ions and also has the effect of suppressing liquid separation.
As component (A), alkali metal salts such as potassium salts and sodium salts of tripolyphosphoric acid and pyrophosphoric acid can be used, and potassium pyrophosphate is particularly preferred. These may be used alone or in combination of two or more.
(A)成分の配合量は、組成物全体の0.1~1.5%(質量%、以下同様)であり、好ましくは0.15~1.4%、より好ましくは0.3~1.0%である。配合量が0.1%未満であると、フッ素イオンの滞留性及びその放出性が劣り、また、経時で液分離が生じて液分離安定性に劣る。1.5%を超えると、フッ素イオンの滞留性及びその放出性が低下し、経時で固化が生じ固化安定性に劣る。 The blending amount of component (A) is 0.1 to 1.5% (mass%, the same applies hereinafter) of the entire composition, preferably 0.15 to 1.4%, more preferably 0.3 to 1. .0%. If the blending amount is less than 0.1%, fluorine ion retention and release properties will be poor, and liquid separation will occur over time, resulting in poor liquid separation stability. If it exceeds 1.5%, the retention and release properties of fluorine ions will decrease, and solidification will occur over time, resulting in poor solidification stability.
(B)水溶性カルシウム塩は、フッ素イオンの滞留性の向上作用を奏し、また、固化抑制作用を奏する。
水溶性カルシウム塩は、例えば塩化カルシウム、硝酸カルシウム、酢酸カルシウム、クエン酸カルシウム、グルコン酸カルシウム、安息香酸カルシウム、ギ酸カルシウム、フマル酸カルシウム、乳酸カルシウム、酪酸カルシウム及びイソ酪酸カルシウム、リンゴ酸カルシウム、マレイン酸カルシウム、プロピロン酸カルシウム、吉草酸カルシウム等が挙げられ、特に塩化カルシウムが好ましい。
(B) The water-soluble calcium salt has the effect of improving the retention of fluorine ions and also has the effect of inhibiting solidification.
Water-soluble calcium salts include, for example, calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate and calcium isobutyrate, calcium malate, calcium malate, calcium Examples include calcium acid, calcium propylonate, calcium valerate, and calcium chloride is particularly preferred.
(B)水溶性カルシウム塩の配合量は、組成物全体の0.1~1.5%であり、好ましくは0.1~0.7%、より好ましくは0.3~0.7%である。配合量が0.1%未満であると、フッ素イオンの滞留性及びその放出性が劣り、また、経時で固化し易くなり、固化安定性に劣る。1.5%を超えると、フッ素イオンの滞留性及びその放出性が劣り、また、経時で液分離が生じて液分離安定性に劣る。 (B) The amount of water-soluble calcium salt blended is 0.1 to 1.5% of the total composition, preferably 0.1 to 0.7%, more preferably 0.3 to 0.7%. be. If the blending amount is less than 0.1%, fluorine ion retention and release properties are poor, and solidification tends to occur over time, resulting in poor solidification stability. If it exceeds 1.5%, fluorine ion retention and release properties will be poor, and liquid separation will occur over time, resulting in poor liquid separation stability.
(C)フッ化ナトリウムの配合量は、組成物全体の0.11~1.1%が好ましく、より好ましくは0.32~0.66%である。配合量が0.11%以上であると、フッ素イオンの滞留性の向上効果が十分に得られる。1.1%以下であると、過剰摂取による斑状歯等の為害作用の発生を十分に防止できる。 The amount of sodium fluoride (C) blended is preferably 0.11 to 1.1%, more preferably 0.32 to 0.66% of the total composition. When the blending amount is 0.11% or more, the effect of improving the retention of fluorine ions can be sufficiently obtained. When the content is 1.1% or less, harmful effects such as mottled teeth due to excessive intake can be sufficiently prevented.
本発明では、(A)成分と(C)成分との量比を示す(A)/(C)が、モル比として好ましくは0.05~1、より好ましくは0.1~0.5、特に0.10~0.50である。また、(B)成分と(C)成分との量比を示す(B)/(C)が、モル比として好ましくは0.1~2、より好ましくは0.3~1である。(A)/(C)のモル比、(B)/(C)のモル比がそれぞれ上記範囲内であると、更に好ましい。これらモル比の範囲内で(C)成分を配合すると、フッ素イオンの滞留性及びその放出性がより優れ、また、液分離安定性及び固化安定性がより優れる。 In the present invention, (A)/(C) indicating the quantitative ratio of component (A) and component (C) is preferably 0.05 to 1 as a molar ratio, more preferably 0.1 to 0.5, In particular, it is 0.10 to 0.50. Furthermore, the molar ratio (B)/(C) indicating the quantitative ratio of component (B) to component (C) is preferably 0.1 to 2, more preferably 0.3 to 1. It is more preferable that the molar ratio of (A)/(C) and the molar ratio of (B)/(C) are each within the above ranges. When component (C) is blended within these molar ratio ranges, fluorine ion retention and release properties are better, and liquid separation stability and solidification stability are also better.
(D)カチオン化セルロースは、(B)及び(C)成分と組み合わせることで、(C)成分由来のフッ素イオンの滞留性を向上し、かつその放出性を改善する作用を奏し、また、液分離安定性を改善する作用を奏する。 (D) Cationized cellulose, when combined with components (B) and (C), has the effect of improving the retention of fluorine ions derived from component (C) and improving its release properties, and also It has the effect of improving separation stability.
カチオン化セルロースは、カチオンを有するセルロース、又はカチオンを有するセルロース誘導体である。カチオン化セルロースは、対イオン(例えばハロゲンイオン(塩素イオン)、メトサルフェートイオン等)を有していてもよい。カチオン化セルロースの分子量は特に限定されない。(D)成分として、カチオン化セルロースは1種を単独で用いてもよいし、2種以上を組み合わせて用いてもよい。
カチオン化セルロースの例としては、ヒドロキシエチルセルロースジメチルジアリルアンモニウム塩、塩化O-[2-ヒドロキシ-3-(トリメチルアンモニオ)プロピル]ヒドロキシエチルセルロースが挙げられ、好ましくはヒドロキシエチルセルロースジメチルジアリルアンモニウム塩である。
ヒドロキシエチルセルロースジメチルジアリルアンモニウム塩は、対イオンとしては塩化物イオンが挙げられ、ヒドロキシエチルセルロースジメチルジアリルアンモニウムクロリドが好適である。
本発明で用いるカチオン化セルロースは、その2%水溶液粘度(BH型ブルックフィールド粘度計、ローターNo.2、20回転、20℃、測定時間1分)が30~3,000mPa・sであることが好ましい。
カチオン化セルロースの平均分子量は、特に限定されないが、ポリエチレングリコールを標準物質としたゲルパーミエーションクロマトグラフ(GPC)法による重量平均分子量で、好ましくは100,000~1,500,000である。窒素含有量としては0.1~3%が好ましく、より好ましくは0.5~2.5%である。
このようなカチオン化セルロースとしては、例えば、アクゾノーベル(株)から市販されているCELQUAT L-200(2%粘度:35~350mPa・s、BH型ブルックフィールド粘度計、ローターNo.2、20回転、20℃、測定時間1分)、ポリエチレングリコールを標準物質としたゲルパーミエーションクロマトグラフ(GPC)法による重量平均分子量:250,000~350,000)が挙げられ、使用できる。
Cationized cellulose is cellulose with cations or cellulose derivatives with cations. The cationized cellulose may have counter ions (for example, halogen ions (chloride ions), methosulfate ions, etc.). The molecular weight of cationized cellulose is not particularly limited. As component (D), one type of cationized cellulose may be used alone, or two or more types may be used in combination.
Examples of cationized cellulose include hydroxyethylcellulose dimethyldiallylammonium salt, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, and hydroxyethylcellulose dimethyldiallylammonium salt is preferred.
Hydroxyethylcellulose dimethyldiallylammonium salt includes a chloride ion as a counter ion, and hydroxyethylcellulose dimethyldiallylammonium chloride is preferred.
The cationized cellulose used in the present invention has a 2% aqueous solution viscosity (BH Brookfield viscometer, rotor No. 2, 20 rotations, 20°C, measurement time 1 minute) of 30 to 3,000 mPa・s. preferable.
The average molecular weight of the cationized cellulose is not particularly limited, but is preferably 100,000 to 1,500,000 as determined by gel permeation chromatography (GPC) using polyethylene glycol as a standard substance. The nitrogen content is preferably 0.1 to 3%, more preferably 0.5 to 2.5%.
As such cationized cellulose, for example, CELQUAT L-200 (2% viscosity: 35 to 350 mPa・s, BH type Brookfield viscometer, rotor No. 2, 20 rotations) commercially available from Akzo Nobel Co., Ltd. , 20°C, measurement time: 1 minute), weight average molecular weight measured by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance: 250,000 to 350,000), and can be used.
(D)成分の配合量は、組成物全体の0.01~0.5%が好ましく、より好ましくは0.05~0.2%である。0.01%以上配合すると、フッ素イオンの滞留性及びその放出性が十分に得られ、また、経時でも液分離が抑制され十分な液分離安定性が得られる。0.5%以下であると、口腔粘膜への違和感が十分に抑制される。 The blending amount of component (D) is preferably 0.01 to 0.5%, more preferably 0.05 to 0.2% of the total composition. When 0.01% or more is added, sufficient retention and release properties of fluorine ions can be obtained, liquid separation is suppressed over time, and sufficient liquid separation stability can be obtained. When it is 0.5% or less, discomfort to the oral mucosa is sufficiently suppressed.
また、(A)成分と(D)成分との量比を示す(A)/(D)は、質量比として1~50が好ましく、より好ましくは3~25である。また、(B)成分と(D)成分との量比を示す(B)/(D)は、質量比として1~50が好ましく、より好ましくは2~20であり、(C)成分と(D)成分との量比を示す(C)/(D)は、質量比として1~20が好ましく、より好ましくは1~10である。これら質量比の範囲内で(D)成分を配合すると、(D)成分による効果が十分に発揮され、フッ素イオンの滞留性及びその放出性がより優れ、また、液分離安定性がより優れる。 Furthermore, (A)/(D), which indicates the quantitative ratio of component (A) to component (D), is preferably 1 to 50 as a mass ratio, and more preferably 3 to 25. In addition, (B)/(D), which indicates the quantitative ratio of component (B) to component (D), is preferably 1 to 50 as a mass ratio, more preferably 2 to 20, and the mass ratio of component (C) and ( (C)/(D), which indicates the quantitative ratio with component D), is preferably 1 to 20 as a mass ratio, more preferably 1 to 10. When component (D) is blended within these mass ratio ranges, the effects of component (D) are fully exhibited, the retention and release of fluorine ions are better, and the liquid separation stability is better.
本発明の歯磨剤組成物は、特に練歯磨剤組成物として好適であり、また、上記成分に加えて、その他の公知成分を本発明の効果を妨げない範囲で必要に応じて配合できる。例えば、研磨剤、粘結剤、粘稠剤、界面活性剤、更に必要により着色剤、甘味料、防腐剤、香料、有効成分等を配合できる。なお、歯磨剤組成物の調製方法は、特に限定されず、剤型に応じた公知の方法でよく、例えば、(A)~(D)成分、更には任意成分、水を通常の方法で配合し、調製できる。 The dentifrice composition of the present invention is particularly suitable as a dentifrice composition, and in addition to the above-mentioned components, other known components may be added as necessary within a range that does not impede the effects of the present invention. For example, abrasives, binders, thickeners, surfactants, and if necessary, colorants, sweeteners, preservatives, fragrances, active ingredients, etc. can be added. The method for preparing the dentifrice composition is not particularly limited and may be any known method depending on the dosage form. and can be prepared.
研磨剤は、例えば無水ケイ酸、沈降性シリカ、シリカゲル、アルミノシリケート、ジルコノシリケート等のシリカ系研磨剤、第2リン酸カルシウム・2水和物又は無水和物、第1リン酸カルシウム、第3リン酸カルシウム、第4リン酸カルシウム、ピロリン酸カルシウム等のリン酸カルシウム系化合物、炭酸カルシウム、水酸化カルシウム、水酸化アルミニウム、不溶性メタリン酸ナトリウム、第3リン酸マグネシウム、炭酸マグネシウム、硫酸カルシウム、ベントナイト、チタニウム結合ケイ酸塩、合成樹脂系研磨剤が挙げられる。中でも、シリカ系研磨剤が好ましい。
研磨剤の配合量は、組成物全体の5~60%、特に5~30%が好ましい。
Examples of the abrasive include silica-based abrasives such as anhydrous silicic acid, precipitated silica, silica gel, aluminosilicate, and zirconosilicate, dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, tertiary calcium phosphate, Calcium phosphate compounds such as calcium tetraphosphate and calcium pyrophosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, titanium-bonded silicate, synthetic resin type Examples include abrasives. Among these, silica-based abrasives are preferred.
The amount of abrasive compounded is preferably 5 to 60%, particularly 5 to 30% of the total composition.
粘結剤は、有機又は無機粘結剤を配合できる。具体的には、カルボキシメチルセルロースナトリウム、メチルセルロース、ヒドロキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシメチルエチルセルロース等のセルロース誘導体、アルギン酸ナトリウム等のアルギン酸誘導体、キサンタンガム、トラガカントガム、カラヤガム、アラビアガム等のガム類、カラギーナン、ポリビニルアルコール、カルボキシビニルポリマーといった有機粘結剤、増粘性シリカ、増粘性アルミニウムシリカ、ビーガム、ラポナイト等の無機粘結剤が挙げられる。
粘結剤の配合量は、組成物全体の0.2~3%が好ましい。なお、本発明では、特に有機粘結剤が好ましく、有機粘結剤の配合量は、組成物全体の0.1~5%、特に0.5~3%がよい。無機粘結剤、特に増粘性シリカは、フッ素イオンの滞留性の点で、配合する場合は組成物全体の5%以下、特に2%以下、とりわけ1%以下が好ましく、配合せず0%でもよい。
The binder can be an organic or inorganic binder. Specifically, cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and hydroxymethylethylcellulose, alginic acid derivatives such as sodium alginate, xanthan gum, gum tragacanth, gum karaya, gum arabic, etc. Examples include organic binders such as gums, carrageenan, polyvinyl alcohol, and carboxyvinyl polymer, and inorganic binders such as thickening silica, thickening aluminum silica, vegum, and laponite.
The blending amount of the binder is preferably 0.2 to 3% of the total composition. In the present invention, organic binders are particularly preferred, and the amount of organic binders to be blended is preferably 0.1 to 5%, particularly 0.5 to 3%, based on the total composition. Inorganic binders, especially thickening silica, are preferably used in an amount of 5% or less, particularly 2% or less, especially 1% or less of the total composition, from the viewpoint of retention of fluoride ions, and even if not added, it may be 0%. good.
粘稠剤は、ソルビット、キシリット、エリスリトール、マルチット、ラクチット等の糖アルコール、グリセリン、プロピレングリコール、平均分子量160~400(医薬部外品原料規格2006記載の平均分子量)のポリエチレングリコール等の多価アルコールが挙げられる。粘稠剤の配合量は、通常、組成物全体の5~60%がよい。 Thickeners include sugar alcohols such as sorbitol, xylitol, erythritol, maltit, and lactit; polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol with an average molecular weight of 160 to 400 (average molecular weight according to the Standards for Quasi-drug Ingredients 2006). can be mentioned. The amount of the thickener added is usually 5 to 60% of the total composition.
界面活性剤は、アニオン性界面活性剤、ノニオン性界面活性剤、両性界面活性剤を配合することができる。
アニオン性界面活性剤は、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム等のアルキル硫酸塩、ラウロイルサルコシンナトリウム、ミリストイルサルコシンナトリウム等のアシルサルコシン酸塩、ドデシルベンゼンスルホン酸ナトリウム、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸ナトリウム、ラウリルスルホ酢酸ナトリウムや、N-パルミトイルグルタミン酸ナトリウム等のアシルグルタミン酸塩、N-メチル-N-アシルタウリンナトリウム、N-メチル-N-アシルアラニンナトリウム、α-オレフィンスルホン酸ナトリウムが挙げられる。
ノニオン性界面活性剤は、ポリオキシエチレンアルキルエーテル(例えばアルキル基の炭素数が16~18のもの)、ポリオキシエチレン硬化ヒマシ油(例えばエチレンオキサイドの平均付加モル数が40~80のもの)、アルキルグルコシド、ポリオキシエチレンポリオキシプロピレンブロック共重合体、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、アルキロールアマイド、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンポリオキシプロピレングリコール等が挙げられる。
両性界面活性剤は、ラウリルジメチルアミノ酢酸ベタイン、N-ヤシ油脂肪酸アシル-N-カルボキシメチル-N-ヒドロキシエチルエチレンジアミン、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピル等が挙げられる。
界面活性剤の配合量は、通常、組成物全体の0.1~10%がよい。配合量は、歯磨剤組成物の形態、使用目的等に応じ調整でき、例えば、練歯磨には0.1~10%配合することができる。
As the surfactant, anionic surfactants, nonionic surfactants, and amphoteric surfactants can be blended.
Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, acyl sarcosinates such as sodium lauroyl sarcosine and sodium myristoyl sarcosine, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, and lauryl sulfate. Examples include sodium sulfoacetate, acylglutamates such as sodium N-palmitoylglutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, and sodium α-olefin sulfonate.
Nonionic surfactants include polyoxyethylene alkyl ether (for example, those in which the alkyl group has 16 to 18 carbon atoms), polyoxyethylene hydrogenated castor oil (for example, in which the average number of added moles of ethylene oxide is 40 to 80), Alkyl glucosides, polyoxyethylene polyoxypropylene block copolymers, polyglycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, alkylolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, etc. It will be done.
Examples of the amphoteric surfactant include lauryldimethylaminoacetic acid betaine, N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, and coconut oil fatty acid amidopropyl fatty acid.
The amount of surfactant to be blended is usually 0.1 to 10% of the total composition. The blending amount can be adjusted depending on the form of the dentifrice composition, the purpose of use, etc., and for example, it can be blended in a toothpaste in an amount of 0.1 to 10%.
着色剤は、赤色2号、赤色3号、赤色225号、赤色226号、黄色4号、黄色5号、黄色205号、青色1号、青色2号、青色201号、青色204号、緑色3号、雲母チタン、酸化チタン等が挙げられる。
甘味料は、サッカリンナトリウム、アスパルテーム、ステビオサイド、ステビアエキス、パラメトキシシンナミックアルデヒド、ネオヘスペリジンジヒドロカルコン、ペリラルチン等が挙げられる。
防腐剤は、メチルパラベン、エチルパラベン、ブチルパラベン等のパラオキシ安息香酸エステル、安息香酸ナトリウム等の安息香酸又はその塩が挙げられる。
The colorants are Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green 3. Examples include titanium mica, titanium oxide, etc.
Examples of sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, and the like.
Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, and benzoic acids or salts thereof such as sodium benzoate.
香料は、ペパーミント油、スペアミント油、アニス油、ユーカリ油、ウィンターグリーン油、カシア油、クローブ油、タイム油、セージ油、レモン油、オレンジ油、ハッカ油、カルダモン油、コリアンダー油、マンダリン油、ライム油、ラベンダー油、ローズマリー油、ローレル油、カモミル油、キャラウェイ油、マジョラム油、ベイ油、レモングラス油、オリガナム油、パインニードル油、ネロリ油、ローズ油、ジャスミン油、グレープフルーツ油、スウィーティー油、柚油、イリスコンクリート、アブソリュートペパーミント、アブソリュートローズ、オレンジフラワー等の天然香料や、これら天然香料の加工処理(前溜部カット、後溜部カット、分留、液液抽出、エッセンス化、粉末香料化等)した香料、及び、メントール、カルボン、アネトール、シネオール、サリチル酸メチル、シンナミックアルデヒド、オイゲノール、3-l-メントキシプロパン-1,2-ジオール、チモール、リナロール、リナリールアセテート、リモネン、メントン、メンチルアセテート、N-置換-パラメンタン-3-カルボキサミド、ピネン、オクチルアルデヒド、シトラール、プレゴン、カルビールアセテート、アニスアルデヒド、エチルアセテート、エチルブチレート、アリルシクロヘキサンプロピオネート、メチルアンスラニレート、エチルメチルフェニルグリシデート、バニリン、ウンデカラクトン、ヘキサナール、ブタノール、イソアミルアルコール、ヘキセノール、ジメチルサルファイド、シクロテン、フルフラール、トリメチルピラジン、エチルラクテート、エチルチオアセテート等の単品香料、更に、ストロベリーフレーバー、アップルフレーバー、バナナフレーバー、パイナップルフレーバー、グレープフレーバー、マンゴーフレーバー、バターフレーバー、ミルクフレーバー、フルーツミックスフレーバー、トロピカルフルーツフレーバー等の調合香料等、歯磨剤組成物に用いられる公知の香料素材を組み合わせて使用することができる。
また、配合量も特に限定されないが、上記の香料素材は、製剤組成中に0.000001~1%使用することが好ましい。また、上記香料素材を使用した賦香用香料としては、製剤組成中に0.05~2%使用することが好ましい。
Fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil Natural fragrances such as , yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, etc., and processing of these natural fragrances (front distillation cut, rear distillation cut, fractional distillation, liquid-liquid extraction, essence formation, powder fragrance) menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linaryl acetate, limonene, menthone , menthyl acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methyl anthranilate, ethyl methyl Individual flavors such as phenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethylthioacetate, as well as strawberry flavor, apple flavor, and banana flavor. , pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, tropical fruit flavor, and other known flavor materials used in dentifrice compositions can be used in combination.
Further, the amount of the above fragrance material is preferably used in the formulation composition in an amount of 0.000001 to 1%, although there are no particular limitations on the amount. Furthermore, it is preferable to use 0.05 to 2% of the above-mentioned fragrance materials in the formulation composition.
有効成分としては、イソプロピルメチルフェノール、塩化セチルピリジニウム等の殺菌剤、正リン酸のカリウム塩、ナトリウム塩等の水溶性リン酸化合物、デキストラナーゼ、ムタナーゼ、アミラーゼ、プロテアーゼ等の酵素、トラネキサム酸、イプシロンアミノカプロン酸、トリクロサン、塩化リゾチーム、アルミニウムクロルヒドロキシアラントイン、ヒノキチオール、アスコルビン酸、酢酸トコフェロール、ジヒドロコレステロール、α-ビサボロール、クロルヘキシジン塩類、アズレンや、銅クロロフィリンナトリウム、クロロフィル、グルコン酸銅等の水溶性銅化合物、乳酸アルミニウム、塩化ストロンチウム、硝酸カリウム、ベルベリン、ヒドロキサム酸又はその誘導体、グルチルリチン酸又はその塩、グリチルレチン酸又はその誘導体、歯石防止剤が挙げられる。なお、上記有効成分は、本発明の効果を妨げない範囲で有効量配合することができる。 Active ingredients include disinfectants such as isopropylmethylphenol and cetylpyridinium chloride, water-soluble phosphoric acid compounds such as potassium salts and sodium salts of orthophosphoric acid, enzymes such as dextranase, mutanase, amylase, and protease, tranexamic acid, Water-soluble copper compounds such as epsilon aminocaproic acid, triclosan, lysozyme chloride, aluminum chlorohydroxyallantoin, hinokitiol, ascorbic acid, tocopherol acetate, dihydrocholesterol, α-bisabolol, chlorhexidine salts, azulene, sodium copper chlorophyllin, chlorophyll, copper gluconate, etc. , aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid or its derivatives, glutyrrhizic acid or its salts, glycyrrhetinic acid or its derivatives, and anti-tartar agents. In addition, the above-mentioned active ingredients can be blended in an effective amount within a range that does not impede the effects of the present invention.
以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、下記の例において%は特に断らない限りいずれも質量%を示す。 EXAMPLES Hereinafter, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to the Examples below. In addition, in the following examples, % indicates mass % unless otherwise specified.
[実施例、比較例]
表1~3に示す組成の歯磨剤組成物(練歯磨)を常法によって調製し、下記方法で評価した。結果を表に併記した。
[Examples, comparative examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following method. The results are also listed in the table.
(1)フッ素(フッ素イオン)滞留性の評価方法
フッ素(フッ素イオン)の口腔粘膜成分であるムチンへの吸着性試験により、フッ素イオンの滞留性を評価した。
10mL遠心チューブにムチン(Sigma-Aldrich社製)を0.2g添加し、更に歯磨剤組成物(精製水による40倍希釈液)を5mL加え、3分間作用させた。その後、3,000rpmで10分間遠心分離し、上清を除去した。得られたムチンに、クエン酸カリウム緩衝液を5mL加えて1分間撹拌し、ムチンに吸着・滞留したフッ素イオンを強制的に溶出させた。3,000rpmで10分間遠心分離して上清を回収し、溶液に含まれるフッ素(フッ素イオン)濃度をフッ素イオンメーター(Orion 1115000 4-Star:サーモフィッシャーサイエンティフィック(株)製)で測定し、滞留フッ素イオン濃度(ppm)を得た。
フッ素イオン滞留率を以下の式により算出した。
フッ素イオン滞留率(%)=
{(滞留フッ素イオン濃度(ppm))/(製剤に配合したフッ素イオン濃度(ppm)/40)}×100
フッ素イオン滞留率から、下記の評価基準でフッ素イオン滞留性を評価した。
評価基準
◎:フッ素イオン滞留率が50%以上
〇:フッ素イオン滞留率が30%以上50%未満
△:フッ素イオン滞留率が20%以上30%未満
×:フッ素イオン滞留率が20%未満
(1) Evaluation method of fluorine (fluoride ion) retention The retention of fluoride ions was evaluated by an adsorption test of fluorine (fluoride ion) to mucin, which is a component of the oral mucosa.
0.2 g of mucin (manufactured by Sigma-Aldrich) was added to a 10 mL centrifuge tube, and 5 mL of a dentifrice composition (40 times diluted with purified water) was added and allowed to act for 3 minutes. Thereafter, the mixture was centrifuged at 3,000 rpm for 10 minutes, and the supernatant was removed. 5 mL of potassium citrate buffer was added to the obtained mucin and stirred for 1 minute to forcibly elute the fluorine ions adsorbed and retained in the mucin. The supernatant was collected by centrifugation at 3,000 rpm for 10 minutes, and the concentration of fluorine (fluoride ions) contained in the solution was measured using a fluorine ion meter (Orion 1115000 4-Star: manufactured by Thermo Fisher Scientific Co., Ltd.). , the retained fluorine ion concentration (ppm) was obtained.
The fluorine ion retention rate was calculated using the following formula.
Fluorine ion retention rate (%) =
{(Residual fluoride ion concentration (ppm))/(Fluoride ion concentration (ppm) blended into the preparation/40)}×100
Fluorine ion retention was evaluated based on the fluorine ion retention rate using the following evaluation criteria.
Evaluation criteria ◎: Fluorine ion retention rate is 50% or more ○: Fluorine ion retention rate is 30% or more and less than 50% △: Fluorine ion retention rate is 20% or more and less than 30% ×: Fluorine ion retention rate is less than 20%
(2)フッ素(フッ素イオン)放出性の評価方法
(1)で△以上の評価の組成(実施例1~13、比較例2)に対して、ムチンから唾液へのフッ素イオンの放出量(放出率)及び徐放性について評価を行った。
10mL遠心チューブにムチン(Sigma-Aldrich社製)を0.2g添加し、更に歯磨剤組成物(精製水による40倍希釈液)を5mL加え、3分間作用させた。その後、3,000rpmで10分間遠心分離し、上清を除去した。
得られたムチンに、人工唾液(CaCl2=1.5mmol/L、KH2PO4=5.0mmol/L、酢酸=100mmol/L、NaCl=100mmol/L、残部=水;pH=7.0)を5mL加えて1分間撹拌し、3分間、60分間又は180分間静置し、ムチンに吸着・滞留したフッ素イオンを溶出させた後、各々3,000rpmで10分間遠心分離して上清を回収し、溶液に含まれるフッ素イオン濃度をフッ素イオンメーター(Orion 1115000 4-Star:サーモフィッシャーサイエンティフィック(株)製)で測定し、各々の放出フッ素イオン濃度を得た。
放出フッ素イオン濃度から、フッ素イオン放出率を以下の式により算出した。
フッ素イオン放出率(%)=
{(放出フッ素イオン濃度(ppm))/(滞留フッ素イオン濃度(ppm))}×
100
算出したフッ素イオン放出率から、フッ素放出性(放出量)について評価した。
実施例1~13、比較例2の組成物の3分間静置後のフッ素イオン放出率はいずれも20%未満、60分間静置後のフッ素イオン放出率はいずれも20~60%の範囲であり、即時放出せず徐放性があることを確認した。
180分間静置後のフッ素イオン放出率から、下記の評価基準でフッ素放出性を評価した。〇又は◎のものが、ムチンに吸着・滞留したフッ素イオンが唾液によって徐々に放出され、フッ素放出性が合格であると判断した。
評価基準
◎:180分間静置後のフッ素イオン放出率が70%以上
〇:180分間静置後のフッ素イオン放出率が50%以上70%未満
△:180分間静置後のフッ素イオン放出率が20%以上50%未満
×:180分間静置後のフッ素イオン放出率が20%未満
(2) Method for evaluating fluorine (fluoride ion) release properties For compositions that were evaluated as △ or higher in (1) (Examples 1 to 13, Comparative Example 2), the amount of fluoride ions released from mucin to saliva (released rate) and sustained release properties were evaluated.
0.2 g of mucin (manufactured by Sigma-Aldrich) was added to a 10 mL centrifuge tube, and 5 mL of a dentifrice composition (40 times diluted with purified water) was added and allowed to act for 3 minutes. Thereafter, the mixture was centrifuged at 3,000 rpm for 10 minutes, and the supernatant was removed.
To the obtained mucin, artificial saliva (CaCl 2 = 1.5 mmol/L, KH 2 PO 4 = 5.0 mmol/L, acetic acid = 100 mmol/L, NaCl = 100 mmol/L, remainder = water; pH = 7.0 ) was added, stirred for 1 minute, left to stand for 3 minutes, 60 minutes, or 180 minutes to elute the fluorine ions adsorbed and retained in mucin, and then centrifuged at 3,000 rpm for 10 minutes to remove the supernatant. The fluorine ion concentration contained in the solution was measured using a fluorine ion meter (Orion 1115000 4-Star: manufactured by Thermo Fisher Scientific Co., Ltd.) to obtain the released fluorine ion concentration of each solution.
The fluoride ion release rate was calculated from the released fluoride ion concentration using the following formula.
Fluorine ion release rate (%) =
{(released fluorine ion concentration (ppm))/(retained fluorine ion concentration (ppm))}×
100
The fluorine release property (release amount) was evaluated from the calculated fluorine ion release rate.
The fluoride ion release rates of the compositions of Examples 1 to 13 and Comparative Example 2 after standing for 3 minutes were all less than 20%, and the fluoride ion release rates after standing for 60 minutes were all in the range of 20 to 60%. It was confirmed that there was no immediate release but sustained release.
The fluorine release property was evaluated based on the fluoride ion release rate after standing for 180 minutes using the following evaluation criteria. If ○ or ◎, the fluoride ions adsorbed and retained in mucin were gradually released by saliva, and the fluoride release property was judged to be acceptable.
Evaluation criteria ◎: Fluoride ion release rate after standing for 180 minutes is 70% or more. ○: Fluoride ion release rate after standing for 180 minutes is 50% or more and less than 70%. △: Fluoride ion release rate after standing for 180 minutes is 20% or more and less than 50% ×: Fluorine ion release rate after standing for 180 minutes is less than 20%
(3)保存安定性の評価方法
(3-1)製剤の液分離安定性(保存後の液分離のなさ)の評価方法
歯磨剤組成物を50gずつチューブ容器(素材:最内層が直鎖状低密度ポリエチレンからなる直径26mmのラミネートチューブ(大日本印刷(株))製)3本に充填し、40℃で1ヶ月間保存した。保存後に各チューブ容器から歯磨剤組成物を紙の上に押し出し、液分離の状態を下記の評点基準で判定した。3本の平均点を求め、下記の評価基準で製剤の液分離安定性を評価した。
評点基準
4点:液分離が全くなかった
3点:口元部に液分離がわずかに認められたが問題ないレベルだった
2点:口元部及び練表面の液分離が認められた
1点:チューブから歯磨を押し出した時、分離液が垂れだす程度に認められた
評価基準
◎:平均点が4.0点
〇:平均点が3.0点以上4.0点未満
△:平均点が2.0点以上3.0点未満
×:平均点が2.0点未満
(3) Method for evaluating storage stability (3-1) Method for evaluating liquid separation stability (no liquid separation after storage) of the preparation 50 g of the dentifrice composition was placed in a tube container (material: innermost layer is linear) The mixture was filled into three laminate tubes (manufactured by Dainippon Printing Co., Ltd.) made of low-density polyethylene and having a diameter of 26 mm, and stored at 40° C. for one month. After storage, the dentifrice composition was extruded from each tube container onto paper, and the state of liquid separation was evaluated using the following scoring criteria. The average score of the three samples was calculated, and the liquid separation stability of the formulation was evaluated using the following evaluation criteria.
Scoring criteria 4 points: No liquid separation at all 3 points: Slight liquid separation was observed at the mouth area, but it was at a level that was not a problem 2 points: Liquid separation was observed at the mouth area and the kneading surface 1 point: Tube When the toothpaste was pushed out, the separated liquid was observed to drip out.Evaluation criteria: ◎: Average score is 4.0 points. ○: Average score is 3.0 points or more and less than 4.0 points. △: Average score is 2.0 points. 0 points or more and less than 3.0 points ×: Average score is less than 2.0 points
(3-2)製剤の固化安定性(保存後の固化のなさ)の評価方法
歯磨剤組成物を50gずつチューブ容器(素材:最内層が直鎖状低密度ポリエチレンからなる直径26mmのラミネートチューブ(大日本印刷(株))製)3本に充填し、40℃で1ヶ月間保存した。保存後に各チューブ容器から歯磨剤組成物を押し出し、固化の状態を下記の評点基準で判定した。3本の平均点を求め、下記の評価基準で製剤の固化安定性を評価した。
評点基準
4点:固化が全くなかった
3点:口元部に固化がわずかに認められたが問題ないレベルだった
2点:口元部及び練表面の固化が認められた
1点:チューブから歯磨を押し出せない程度に固化が認められた
評価基準
◎:平均点が4.0点
〇:平均点が3.0点以上4.0点未満
△:平均点が2.0点以上3.0点未満
×:平均点が2.0点未満
(3-2) Method for evaluating the solidification stability (no solidification after storage) of the formulation Place 50 g of the dentifrice composition in a tube container (material: a 26 mm diameter laminate tube whose innermost layer is made of linear low-density polyethylene). (manufactured by Dai Nippon Printing Co., Ltd.) and stored at 40° C. for one month. After storage, the dentifrice composition was extruded from each tube container, and the state of solidification was evaluated using the following scoring criteria. The average score of the three samples was determined, and the solidification stability of the preparation was evaluated using the following evaluation criteria.
Scoring criteria: 4 points: There was no solidification at all. 3 points: There was a slight amount of solidification at the mouth area, but it was at a level that was not a problem. 2 points: There was some solidification at the mouth area and the surface of the toothpaste. 1 point: Toothpaste was removed from the tube. Solidification was observed to the extent that it could not be extruded Evaluation criteria ◎: Average score was 4.0 points ○: Average score was 3.0 points or more and less than 4.0 points △: Average score was 2.0 points or more and less than 3.0 points Less than ×: Average score is less than 2.0 points
使用原料の詳細を下記に示す。
(A)ピロリン酸カリウム;太平化学産業(株)製
(A)トリポリリン酸ナトリウム;太平化学産業(株)製
(B)塩化カルシウム;関東化学(株)製
(C)フッ化ナトリウム;ステラケミファ(株)製
(D)ヒドロキシエチルセルロースジメチルジアリルアンモニウムクロリド;
CELQUAT L-200、アクゾノーベル(株)製、
2%粘度:35~350mPa・s(BH型ブルックフィールド粘度計、ロー
ターNo.2、20回転、20℃、測定時間1分)、
ポリエチレングリコールを標準物質としたゲルパーミエーションクロマトグラ
フ(GPC)法による重量平均分子量:250,000~350,000)
Details of the raw materials used are shown below.
(A) Potassium pyrophosphate; manufactured by Taihei Kagaku Sangyo Co., Ltd. (A) Sodium tripolyphosphate; manufactured by Taihei Kagaku Sangyo Co., Ltd. (B) Calcium chloride; manufactured by Kanto Kagaku Co., Ltd. (C) Sodium fluoride; Stella Chemifa ( Co., Ltd. (D) hydroxyethyl cellulose dimethyl diallylammonium chloride;
CELQUAT L-200, manufactured by Akzo Nobel Co., Ltd.
2% viscosity: 35 to 350 mPa・s (BH type Brookfield viscometer, rotor No. 2, 20 rotations, 20°C, measurement time 1 minute),
Weight average molecular weight determined by gel permeation chromatography (GPC) using polyethylene glycol as a standard substance: 250,000 to 350,000)
Claims (9)
(B)水溶性カルシウム塩を0.1~1.5質量%、
(C)フッ化ナトリウム
及び
(D)カチオン化セルロース
を含有し、(A)/(D)が質量比として1~50、かつ(B)/(D)が質量比として1~50であることを特徴とする歯磨剤組成物。 (A) 0.1 to 1.5% by mass of one or more selected from tripolyphosphate and pyrophosphate;
(B) 0.1 to 1.5% by mass of water-soluble calcium salt;
Contains (C) sodium fluoride and (D) cationized cellulose, the mass ratio of (A)/(D) is 1 to 50, and the mass ratio of (B)/(D) is 1 to 50. A dentifrice composition characterized by:
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006182667A (en) | 2004-12-27 | 2006-07-13 | Lion Corp | Water-containing oral cavity gel composition |
DE102005052400A1 (en) | 2005-10-31 | 2007-05-03 | Henkel Kgaa | Mouth- and tooth-care product, comprises specific formula incorporating tensides for re-mineralizing of teeth |
JP2007161657A (en) | 2005-12-15 | 2007-06-28 | Lion Corp | Dentifrice composition |
JP2009137863A (en) | 2007-12-05 | 2009-06-25 | Lion Corp | Oral cavity composition and method for producing oral cavity composition |
JP2013067567A (en) | 2011-09-21 | 2013-04-18 | Lion Corp | Dentifrice composition |
JP2015117215A (en) | 2013-12-19 | 2015-06-25 | ライオン株式会社 | Dentifrice composition |
JP2017066036A (en) | 2015-09-28 | 2017-04-06 | ライオン株式会社 | Liquid oral composition |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006182667A (en) | 2004-12-27 | 2006-07-13 | Lion Corp | Water-containing oral cavity gel composition |
DE102005052400A1 (en) | 2005-10-31 | 2007-05-03 | Henkel Kgaa | Mouth- and tooth-care product, comprises specific formula incorporating tensides for re-mineralizing of teeth |
JP2007161657A (en) | 2005-12-15 | 2007-06-28 | Lion Corp | Dentifrice composition |
JP2009137863A (en) | 2007-12-05 | 2009-06-25 | Lion Corp | Oral cavity composition and method for producing oral cavity composition |
JP2013067567A (en) | 2011-09-21 | 2013-04-18 | Lion Corp | Dentifrice composition |
JP2015117215A (en) | 2013-12-19 | 2015-06-25 | ライオン株式会社 | Dentifrice composition |
JP2017066036A (en) | 2015-09-28 | 2017-04-06 | ライオン株式会社 | Liquid oral composition |
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