JP5867546B2 - Dentifrice composition, oral anti-inflammatory agent and oral malodor - Google Patents

Description

  The present invention has an excellent effect of suppressing hypersensitivity and has a high periodontal disease-derived bad breath and oral inflammation preventive effect and plaque removal effect, has a good feeling of use, and has hypersensitive symptoms and bad breath and inflammation. It is related with the dentifrice composition effective in suppressing or preventing the symptom derived from periodontal disease, the anti-inflammatory agent for oral cavity, and the halitosis improvement agent.

  Periodontal disease is two major diseases in the oral cavity along with dental caries, and causes about half of the causes of tooth loss. Many periodontal diseases are considered to be infections caused by bacteria, mainly obligate anaerobic gram-negative bacilli, resulting in destruction of connective tissue and alveolar bone. Clinical signs of this process include inflammation, swelling, bleeding, drainage, bad breath, and gum retraction.

  In the living body, neutrophils have a function of killing bacteria and protecting the living body. However, particularly in chronic inflammation, leakage of cellular components and production of excessive active oxygen adversely affect living tissues. Therefore, it is useful to prevent tissue destruction by active oxygen by using an antioxidant such as ascorbic acid and its derivatives. For example, Patent Document 1 proposes that an ascorbic acid ester and a derivative thereof are blended into a dentifrice composition and that this is effective in suppressing halitosis and inflammation derived from periodontal disease.

  Furthermore, in the case of having periodontal disease, gingival retraction occurs, and as a result of exposing the dentin at the root portion, symptoms of hypersensitivity may occur.

  Dentine hypersensitivity is a temporary, very unpleasant pain caused by exposure of the dentin at the root of the tooth and the application of thermal, chemical, mechanical mechanical or other external stimuli. It is defined to be. The cause of this pain is thought to be because the pulp nerve is stimulated through the exposed dentinal tubule.

  Conventionally, many studies have been conducted on the prevention and treatment of dentin hypersensitivity. For example, potassium salts, strontium salts, zinc chloride, aluminum salts and the like are reported in Patent Documents 2 to 5 and the like as effective components for preventing and treating dentin hypersensitivity. In particular, it has been reported in Patent Document 6 and the like that potassium salts blunt sensory nerves and relieve pain due to hypersensitivity by an action of lowering sensory nerve activity due to an increase in extracellular potassium ion concentration. In addition, Patent Documents 6 and 7 report that aluminum salts prevent irritation from being transmitted to nerves in the pulp by constricting or occluding dentinal tubules.

  In the state of having hypersensitivity symptoms, pain is felt even during brushing, so normal brushing is difficult, which makes it difficult to remove plaque and sufficiently remove periodontal disease-causing bacteria. In addition, there is a problem in that oral hygiene is adversely affected and bad breath derived from periodontal disease is likely to occur. If the pain due to hypersensitivity is alleviated more effectively, brushing can be performed more carefully. However, perceptual hypersensitivity components such as aluminum lactate have a strong bitter taste and have a problem in use feeling. Up to now, Patent Documents 8 and 9 describe the improvement in the feeling of use of the dentifrice containing a hypersensitive component, but these effects have not been sufficient. The dentifrice containing the hypersensitivity suppressing component has a problem that it is difficult to polish it carefully for a long time due to its feeling of use.

  Therefore, it is excellent in preventing and treating hypersensitivity symptoms, and even in the state of having hypersensitivity symptoms, more careful brushing is possible, plaque removal is sufficiently performed, and periodontal disease prevention effect is fully demonstrated. Therefore, development of a dentifrice composition with good usability is desired.

  In addition, it is proposed in patent document 10 that the ingredient for reducing the sensitivity of teeth, such as potassium nitrate, can be arbitrarily mix | blended with the oral care composition containing ascorbic acid ester as an auxiliary | assistant active ingredient. However, this technique does not use ascorbic acid ester or a salt thereof in combination with aluminum lactate and / or potassium nitrate, nor does it indicate the content ratio of both components, nor does it suggest the above problem. From such technology, it is expected that combining ascorbic acid ester or a salt thereof with aluminum lactate and / or potassium nitrate will have high perceptual hypersensitivity suppression effect, bad breath improvement effect, inflammation suppression effect and plaque removal effect. It is hard to do.

JP 62-96408 A JP-A-61-36212 US Pat. No. 3,863,006 JP 2006-096696 A JP 2001-172146 A Japanese Patent Laid-Open No. 8-175934 JP 2003-26556 A JP 2003-73282 A JP 2001-172146 A JP 2005-503322 A

Okuda et al., Latest Oral Microbiology (2002) p. 380

  The present invention was made in view of the above circumstances, is excellent in the effect of suppressing hypersensitivity symptoms, can be carefully brushed even if it has hypersensitivity symptoms, and has a high plaque removal effect, derived from periodontal disease Toothbrushes that are effective in improving bad breath and suppressing inflammation, have little bitterness derived from hypersensitivity-inhibiting ingredients, have a good feeling of use, and can effectively suppress symptoms such as bad breath and inflammation derived from periodontal disease An object is to provide an agent composition.

As a result of intensive studies to achieve the above object, the present inventors have obtained (A) at least one selected from ascorbic acid esters and salts thereof, and (B) aluminum lactate , or aluminum lactate and potassium nitrate. When blended so that the content ratio of the component (B) / component (A) is 2 to 50 in terms of mass ratio, both components act synergistically and have an excellent effect of suppressing hypersensitivity symptoms and hypersensitivity. Even users with symptoms can be carefully brushed, which increases plaque removal effect and penetrates active ingredients, resulting in high inflammation suppression effect, bad breath and inflammation derived from periodontal disease, etc. The present inventors have found that a dentifrice composition that can effectively suppress the above symptoms, has little bitterness, and has a good feeling in use can be obtained.

The dentifrice composition of the present invention suppresses hypersensitivity by using (A) at least one selected from ascorbic acid esters and salts thereof and (B) aluminum lactate or aluminum lactate and potassium nitrate at a specific ratio. The bitterness derived from the ingredients is improved and the feeling of use is good. At the same time, since the feeling of use is good, it becomes possible for the user to brush the teeth more carefully over time even when using in a state having hypersensitivity symptoms, and the plaque removal effect is further enhanced. Ascorbic acid ester or a salt thereof can easily reach the target site, so that ascorbic acid ester or its salt-derived inflammation and bad breath suppression effect against inflammation and bad breath caused by periodontal disease is satisfactory It is effective and is effective in preventing or suppressing hypersensitivity and periodontal disease.

  In the present invention, (A) component and (B) component are used in combination at an appropriate ratio, and the synergistic action of both components results in the combination of (A) component or (B) component alone, or the blending ratio of both components. A special effect that cannot be achieved if is inappropriate. In particular, the component (A) is 0.1 to 1% by mass, the component (B) is 2 to 8% by mass, and the content ratio of the component (B) / (A) is 4 to 30 by mass ratio. A dentifrice composition that has an excellent effect on suppression of hypersensitivity, an effect of suppressing inflammation in the oral cavity caused by periodontal disease, an effect of suppressing bad breath, and an effect of removing plaque, and also has a good feeling of use. Can be obtained.

Accordingly, the present invention provides the following dentifrice composition, anti-inflammatory agent for oral cavity, and oral malodor improving agent.
[1]
(A) 0.1 to 1% by mass of one or more selected from ascorbic acid esters and salts thereof,
(B) Dentifrice composition containing 1-5 mass% of aluminum lactate, and the content ratio of (B) component / (A) component is 2-50 by mass ratio.
[2]
(A) one or more selected from ascorbic acid esters and salts thereof;
A dentifrice comprising (B) (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of (B) component / (A) component is 2 to 50 by mass ratio. Composition.
[3]
(A) The dentifrice composition as described in [2] which contains 0.05-2 mass% of components, and contains 1-9 mass% of (B) components.
[4]
(A) 0.05-2 mass% of component, (B) (B-1) 1-5 mass% of aluminum lactate, (B-2) 1-8 mass% of potassium nitrate are contained. Dentifrice composition.
[5]
The dentifrice composition according to any one of [1] to [4], which is used for anti-inflammation or for improving bad breath.
[6]
(A) one or more selected from ascorbic acid esters and salts thereof;
(B) The anti-inflammatory agent for oral cavity which consists of aluminum lactate and whose content ratio of (B) component / (A) component is 2-50 by mass ratio.
[7]
The anti-inflammatory agent for oral cavity according to [6], containing 0.05 to 2% by mass of component (A) and 1 to 5% by mass of component (B).
[8]
(A) one or more selected from ascorbic acid esters and salts thereof;
An anti-inflammatory agent for oral cavity comprising (B) (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of component (B) / component (A) is 2 to 50 in terms of mass ratio.
[9]
The anti-inflammatory agent for oral cavity according to [8], containing 0.05 to 2% by mass of component (A) and 1 to 9% by mass of component (B).
[10]
(A) 0.05-2% by mass of component, (B) (B-1) 1-5% by mass of aluminum lactate, (B-2) 1-8% by mass of potassium nitrate Anti-inflammatory agent for oral cavity .
[11]
(A) one or more selected from ascorbic acid esters and salts thereof;
(B) The bad breath improving agent which consists of aluminum lactate and whose content ratio of (B) component / (A) component is 2-50 by mass ratio.
[12]
The bad breath improving agent according to [11], containing 0.05 to 2% by mass of component (A) and 1 to 5% by mass of component (B).
[13]
(A) one or more selected from ascorbic acid esters and salts thereof;
(B) A bad breath improving agent comprising (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of component (B) / component (A) is 2 to 50 in terms of mass ratio.
[14]
(A) The bad breath improving agent as described in [13] which contains 0.05-2 mass% of components, and contains 1-9 mass% of (B) components.
[15]
(A) 0.05 to 2% by mass of component, (B) (B-1) 1 to 5% by mass of aluminum lactate, (B-2) 1 to 8% by mass of potassium nitrate [13] Bad breath odor improver.

  The dentifrice composition of the present invention is excellent in the effect of suppressing hypersensitivity symptoms, exhibits high plaque removal effect, oral malodor improvement effect and oral inflammation suppression effect, and uses almost no bitterness derived from the hypersensitive component. Even if the user feels good and has symptoms of hypersensitivity, the user can carefully brush the teeth for a long time, and can be used effectively for the prevention and treatment of hypersensitivity and periodontal disease.

  Hereinafter, the present invention will be described in detail. The dentifrice composition of the present invention contains (A) at least one selected from ascorbic acid esters and salts thereof, and (B) aluminum lactate and / or potassium nitrate. .

  Ascorbic acid ester includes one or two or more hydroxyl groups in any of positions 2, 3, 5, and 6 of ascorbic acid and phosphoric acid, polyphosphoric acid, sulfuric acid, fatty acid, and other pharmaceutically acceptable esters. Can be used. For example, ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid-2 -Palmitic acid ester, ascorbic acid-6-palmitic acid ester, ascorbic acid-2-stearic acid ester, ascorbic acid-6-stearic acid ester, ascorbic acid-2,6-dibutyl ester, ascorbic acid-2,6-palmitin Acid ester etc. are mentioned. Moreover, as such salts, alkali metal salts, such as sodium salt, potassium salt, calcium salt, and magnesium salt, alkaline earth metal salt, etc. are mentioned.

  These ascorbic acid esters and salts thereof can be contained singly or in combination of two or more. Among the ascorbic acid esters, the hydroxyl group at the 2- or 3-position of ascorbic acid is an ester particularly from the viewpoint of the stability of the composition. Ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid-2-palmitate, ascorbic acid- 2-stearic acid ester or the like is preferably used.

Among ascorbic acid esters, phosphoric acid esters are dephosphorylated by the enzyme phosphatase that is widely present in the body after being taken into the living body, and act as ascorbic acid. Is particularly preferable. Among the ascorbic acid phosphate salts, magnesium salts and sodium salts are particularly preferable from the viewpoint of the effect of suppressing periodontal odor and inflammation.
These ascorbic acid esters are commercially available from, for example, Showa Denko KK and DSM Nutrition Japan.

  The content of ascorbic acid ester and its salt is 0.05 to 2% (mass%, the same applies hereinafter) of the whole composition, particularly 0.1 to 1% in terms of the effect of suppressing bad breath and inflammation derived from periodontal disease. Is preferred. If it is less than 0.05%, the bad breath / inflammation-suppressing effect derived from periodontal disease may not be sufficient, and if it exceeds 2%, a bitter taste may be felt during use and the feeling of use may be poor.

Aluminum lactate and potassium nitrate are used as a hypersensitivity inhibitor, and aluminum lactate or potassium nitrate may be blended alone, or aluminum lactate and potassium nitrate may be used in combination.
For example, aluminum lactate sold by Musashino Chemical Laboratory can be used.
For example, potassium nitrate sold by Otsuka Chemical Co., Ltd. can be used.

  The total amount of aluminum lactate and / or potassium nitrate is 1 to 9%, preferably 2 to 8% of the total composition. If the blending amount is less than 1%, the perceptual hypersensitivity suppression effect may not be satisfactorily exhibited, and brushing may not be satisfactorily performed, and plaque removal may be insufficient. If it exceeds 9%, the increase in content is commensurate. In addition to being unable to expect an increase in the effect, it may cause a bitter taste and inferior use feeling.

  Further, the content of aluminum lactate is preferably 1 to 5%, particularly 1 to 3% of the whole composition from the viewpoint of the hypersensitivity suppressing effect. If it is less than 1%, the hypersensitivity suppression effect is not satisfactorily exhibited, brushing may not be satisfactory, and plaque removal may be insufficient. Even if it exceeds 5%, the effect corresponding to the increase in content may increase. Not only can not be expected, it may cause a bitter taste and inferior feeling.

  The content of potassium nitrate is preferably 1 to 8%, particularly preferably 2 to 7%, based on the effect of suppressing hypersensitivity. If it is less than 1%, the hypersensitivity suppressing effect is not exhibited satisfactorily and brushing may not be satisfactory, and plaque removal may be insufficient. If it exceeds 8%, the bitterness may be too strong and the feeling of use may be poor.

  In the present invention, the content ratio ((B) / (A)) of the component (A) to the component (B) is 2 to 50, preferably 4 to 30 in terms of mass ratio. The taste of the product is good and the feeling of use is excellent, and a high halitosis and oral inflammation suppression effect, hypersensitivity suppression effect and plaque removal effect are obtained. Furthermore, by using the above blending ratio, the taste is good and the feeling of use is excellent, and the pain when brushing teeth can be suppressed.As a result, periodontal disease-induced bad breath and inflammation can be prevented and dentine hypersensitivity can be suppressed. More careful and sufficient brushing is possible over a long period of time, and more advanced plaque removal is possible. If the mass ratio is less than 2, sufficient sensitivity to hypersensitivity cannot be obtained and brushing cannot be satisfactorily achieved, so plaque removal effect cannot be obtained. If it exceeds 50, sufficient bad breath / inflammation suppression effect cannot be obtained, and bitterness In this case, the effect of the present invention cannot be achieved.

  The dentifrice composition of the present invention is prepared in the form of paste, gel, liquid, liquid, solid, gum, etc., and is used in toothpaste, liquid dentifrice, moisturized dentifrice, powder dentifrice, liquid dentifrice. As a dentifrice such as an agent, it is particularly prepared as a toothpaste, and other additives can be blended as optional components in addition to the essential components according to the dosage form.

  In the case of toothpastes, for example, abrasives, thickeners, binders, surfactants, if necessary, sweeteners, preservatives, colorants (pigments), storage stabilizers, various active ingredients, fragrances, solvents, etc. These components can be mixed and manufactured.

  Here, as the abrasive, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, aluminum hydroxide, calcium hydrogen phosphate dihydrate and anhydrous salts, calcium pyrophosphate, hydroxyapatite, heavy And light calcium carbonate, zirconium silicate, alumina, magnesium carbonate, tribasic magnesium phosphate, synthetic resin-based abrasives, etc., particularly silica-based abrasives. The content of the abrasive is usually 0 to 40%, particularly 2 to 30%.

  As the thickener, polyhydric alcohol, sugar alcohol and the like can be used, and examples thereof include sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lactit and the like. be able to. The content of the thickener is usually 1 to 60%.

  Binders include cellulose derivatives such as carboxymethylcellulose sodium, gums such as xanthan gum, tragacanth gum, karaya gum, and arabic gum, carboxyvinyl polymers such as polyvinyl alcohol, crosslinked sodium polyacrylate, and uncrosslinked sodium polyacrylate, carrageenan And organic binders such as sodium alginate and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, bee gum and laponite. The content of the binder is usually 2 to 10% of the composition.

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be contained. Examples of anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzenesulfonate, hydrogen Added coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, α-olefin sulfone Examples include sodium acid. Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol fatty acid Ether type activator such as polyhydric alcohol fatty acid ester such as ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, lauric acid diethanolamide And fatty acid alkanolamides. Examples of the cationic surfactant include alkylammonium and alkylbenzylammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.
The compounding amount of the surfactant is usually 0 to 15%, particularly 0.5 to 10% of the composition.

  Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances processed with these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and menthol , Carvone, anethole, cineol, methyl salicylate Synamic aldehyde, eugenol, 3-l-mentoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, Citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol , Hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate Used in toothpaste compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. Known perfume materials can be used.

  Moreover, although content is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  Examples of the sweetener include saccharin sodium, stevioside, stevia extract, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, p-methoxycinnamic aldehyde, aspartame, xylitol and the like.

  Examples of the preservative include paraoxybenzoic acid esters such as butylparaben, propylparaben, and ethylparaben, sodium benzoate, cetylpyridinium chloride, isopropylmethylphenol, potassium sorbate, and the like.

Examples of the colorant include Blue No. 1, Blue No. 4, Green No. 3, and the like.
Examples of the storage stabilizer include vitamins such as vitamin E, sulfites such as sodium sulfite, sodium pyrosulfite, and sodium bisulfite, butylhydroxytoluene, propyl gallate, and the like.

  Examples of various active ingredients include those other than the components (A) and (B), for example, monofluorophosphates such as sodium monofluorophosphate, fluorine-containing compounds such as sodium fluoride, potassium salts of normal phosphoric acid, sodium salts Water-soluble phosphate compounds such as allantoin, allantoinchlorohydroxyaluminum, hinokitiol, sodium chloride, dl-tocopherol acetate, coenzyme Q10, dihydrocholesterol, α-bisabolol, chlorhexidine salts, triclosan, isopropylmethylphenol, sanguinarine extract, azulene, Chelating phosphate compounds such as glycyrrhizin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper compounds such as copper gluconate, strontium chloride, berberine, Roxamic acid and its derivatives, pyrophosphate, tripolyphosphate, zeolite, methoxyethylene maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, trichlorocarbanilide , Zinc citrate, dextranase, mutanase, protease, soft extract of sugar beet, extract of buckwheat, chamomile, clove, rosemary, hornon, safflower, etc., in an effective amount within a range that does not interfere with the effect of the present invention be able to.

  In addition, content of these arbitrary components can be made into a normal amount in the range which does not prevent the effect of this invention.

  The dentifrice composition of the present invention is a container such as an aluminum laminate tube or a glass-deposited plastic tube as a container, a dispenser container by mechanical or differential pressure, a film packaging container such as pillow packaging, injection, hollow, press, A bottle or the like formed by vacuum or the like can also be filled.

  EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

Examples and comparative examples
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 4 were prepared by a conventional method, and evaluated by conducting the following experiments. The results are shown in Tables 1-4.

  As each component used for preparation of these dentifrice compositions, ascorbic acid-2-phosphate magnesium (ascorbic acid PM, Showa Denko KK), ascorbic acid-2-phosphate sodium (Stay C-50) , DSM Nutrition Japan), ascorbic acid-2-sulfate (manufactured by ITO), aluminum lactate (manufactured by Musashino Chemical Laboratory), potassium nitrate (manufactured by Otsuka Chemical Co., Ltd.), etc. Precipitated silica, sodium hydroxide, thickening silica, carboxymethylcellulose, sodium lauryl sulfate, sodium monofluorophosphate, sorbit, anhydrous silicic acid, propylene glycol, sodium saccharin, and water The material conforming to the raw material standard 2006 was used. For sorbit, a dentifrice composition was prepared using a 70% aqueous solution product.

[Experimental Example 1] Evaluation of improvement rate of bad breath derived from periodontal disease Evaluation was performed using 10 volunteer subjects having symptoms of hypersensitivity, subjective symptoms of periodontal disease (gum swelling and bleeding), and bad breath. First, the subject was allowed to stop oral cleaning for one day, and 1 L of breath was collected in a fluororesin collection container (Tedlar bag N type 1 L size, manufactured by Sampratec). Ten perfumers were derived from periodontal disease according to the criteria described below. The level of bad breath was evaluated, and the score was S1.
Next, 1g of the test dentifrice was used once, and after twice a day, using the normal method (tooth brushing for 3 minutes using a toothbrush) for 1 month, the oral cleaning was similarly stopped for 1 day, 1 L of exhaled breath is collected in a fluororesin collection container (Tedlar bag N type 1 L size, manufactured by Sampleratech), and 10 perfumers evaluate the level of bad breath derived from periodontal disease according to the evaluation criteria described later. It was.
The degree of improvement in bad breath derived from periodontal disease of each subject was calculated according to the following formula, and the average value of 10 subjects was obtained. This average value was determined according to the criteria described below.
Improvement degree of bad breath derived from periodontal disease = S1-S2

<Evaluation criteria>
5: There is a very strong halitosis derived from periodontal disease.
4: There is a bad breath derived from strong periodontal disease.
3: Slightly bad breath derived from periodontal disease.
2: There is a slight bad breath derived from periodontal disease.
1: There is almost no bad breath derived from periodontal disease.
0: No bad breath derived from periodontal disease.
<Criteria>
◎: 3.5 or more and 5 or less ○: 2.5 or more and less than 3.5 △: 1 or more and less than 2.5 × ×: less than 1

[Experimental example 2] Evaluation of feeling of use Each test toothpaste was used for 10 people with symptoms of dentin hypersensitivity, using 1g of the test dentifrice at a time, and using the usual method for 3 minutes (using a toothbrush with a tooth Was brushed for 3 minutes), and the sensory feeling such as bitterness was evaluated according to the following criteria, and the average of 10 persons was obtained. This average value was determined according to the criteria described below.

<Evaluation criteria>
4: The bitterness is not felt at all and the feeling of use is very good.
3: There is almost no bitterness and there is no problem in the feeling of use.
2: Feels weak bitterness and has a slight problem with the feeling of use.
1: Strongly bitter and unbearable to use.
<Criteria>
◎: 3.5 to 4 points ○: 3 to less than 3.5 points △: 2 to less than 3 points ×: Less than 2 points

[Experimental Example 3] Evaluation of inhibitory effect on hypersensitivity Each toothpaste is used for 10 people with symptoms of dentin hypersensitivity, using 1g of the test dentifrice at a time, using a normal method for 5 minutes (using a toothbrush) The teeth were brushed for 5 minutes), and the pain at that time was evaluated according to the following criteria, and the average of 10 people was obtained. This average value was determined according to the criteria described below.

<Evaluation criteria>
4: Feels no pain at all and can brush teeth for 5 minutes.
3: Feeling slightly painful, but can brush the teeth for 3 minutes, no problem.
2: I feel a little pain, but I can brush my teeth for 1 minute.
1: Feels painful and cannot brush teeth for 1 minute.
<Criteria>
◎: 3.5 to 4 points ○: 3 to less than 3.5 points △: 2 to less than 3 points ×: Less than 2 points

[Experimental example 4] Evaluation of plaque removal effect Each toothpaste is used for 10 people with symptoms of dentin hypersensitivity, using 1g of a test dentifrice at a time, using a normal method for 3 minutes (using a toothbrush) After brushing the teeth for 3 minutes, according to the method of Non-Patent Document 1, plaque staining was carried out and dyed on the four tooth surfaces (mesial, distal, labial, lingual) of each subject at that time It was marked whether plaque was adhered, and PI (plaque index) was calculated from the following formula. The average PI of 10 subjects was determined according to the criteria described below.

PI (%) = ((total number of tooth surfaces to which plaque is adhered) / (number of test tooth surfaces)) × 100
<Evaluation criteria>
4: Less than 25% 3: More than 25% and less than 45% 2: More than 45% and less than 75% 1: More than 75% <Criteria>
◎: 3.5 to 4 points ○: 3 to less than 3.5 points △: 2 to less than 3 points ×: Less than 2 points

[Experimental Example 5] Evaluation of Inflammation Inhibitory Effect Inflammation was caused on a hamster cheek pouch by burns, and about 0.1 g of a specimen (toothpaste composition) was applied on the pouch. The pouch was removed after 5 hours. The mass of the pouch was measured, and the edema suppression rate was calculated from the mass difference from the untreated site (opposite side pouch). This was performed for 8 specimens, and the average edema suppression rate (%) for the untreated site was calculated and judged according to the following criteria.
Average edema suppression rate (%)
= 100-((mass of untreated site-mass of specimen application site) / (mass of untreated site)) × 100

<Criteria>
◎: Average edema inhibition rate is 20% or more ○: Average edema inhibition rate is 10% or more and less than 20% △: Average edema inhibition rate is 5% or more and less than 10% ×: Average edema inhibition rate is less than 5%

＊：Ｌ−アスコルビン酸ナトリウム：扶桑化学工業（株）製

*: Sodium L-ascorbate: manufactured by Fuso Chemical Industry Co., Ltd.

  From the results of Tables 1 to 4, it is derived from periodontal disease in a composition in which any of the components (A) and (B) related to the present invention is not blended or in an inappropriate mass ratio of (B) / (A) It was inferior to any of the bad breath improvement effect, feeling of use, hypersensitivity suppression effect, plaque removal effect, and inflammation suppression effect, and a satisfactory effect was not exhibited. On the other hand, the dentifrice composition of the present invention is excellent in periodontal disease-derived bad breath, hypersensitivity suppression effect, plaque removal effect, inflammation suppression effect, good taste without bitterness and usability It was confirmed to be excellent.

  Next, a dentifrice composition having the following composition was prepared in the same manner as described above and evaluated in the same manner.

[ Reference Example 19] Liquid dentifrice Silicic anhydride 10.0%
Xanthan gum 1.0
Saccharin sodium 0.1
70% sorbite solution 35.0
Glycerin 20.0
Propylene glycol 3.0
Sodium lauryl sulfate 1.2
Sodium bicarbonate 2.0
Decaglyceryl laurate 0.5
Sodium monofluorophosphate 0.73
Potassium nitrate 5.0
Ascorbic acid-2-magnesium phosphate 0.5
Sodium hydroxide 0.4
Fragrance 0.8
Blue No. 1 0.001
Purified water remaining
Total 100.0%

The evaluation results are as follows.
Improvement rate of bad breath derived from periodontal disease ◎
Usability ◎
Hypersensitivity suppression effect ◎
Plaque removal effect ◎
Anti-inflammatory effect ◎

  The same result was obtained when aluminum lactate was used instead of potassium nitrate. The same results were obtained even when sodium ascorbate-2-phosphate was used instead of magnesium ascorbate-2-phosphate.

[ Reference Example 20] Liquid dentifrice Silicic anhydride 10.0%
Xanthan gum 1.0
Saccharin sodium 0.1
70% sorbite solution 35.0
Glycerin 20.0
Propylene glycol 3.0
Sodium lauryl sulfate 1.2
Sodium bicarbonate 2.0
Decaglyceryl laurate 0.5
Sodium monofluorophosphate 0.73
Potassium nitrate 4.0
Ascorbic acid-2-magnesium phosphate 0.2
Sodium hydroxide 0.4
Fragrance 0.8
Blue No. 1 0.001
Purified water remaining
Total 100.0%

The evaluation results are as follows.
Improvement rate of bad breath derived from periodontal disease ◎
Usability ◎
Hypersensitivity suppression effect ◎
Plaque removal effect ◎
Anti-inflammatory effect ◎

  The same result was obtained when aluminum lactate was used instead of potassium nitrate. The same results were obtained even when sodium ascorbate-2-phosphate was used instead of magnesium ascorbate-2-phosphate.

Claims (15)

(A) 0.1 to 1% by mass of one or more selected from ascorbic acid esters and salts thereof,
(B) Dentifrice composition containing 1-5 mass% of aluminum lactate, and the content ratio of (B) component / (A) component is 2-50 by mass ratio. (A) one or more selected from ascorbic acid esters and salts thereof;
A dentifrice comprising (B) (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of (B) component / (A) component is 2 to 50 by mass ratio. Composition.   The dentifrice composition according to claim 2, comprising 0.05 to 2% by mass of component (A) and 1 to 9% by mass of component (B).   The dentifrice of Claim 2 which contains 0.05-2 mass% of (A) component, 1-5 mass% of (B) (B-1) aluminum lactate, and 1-8 mass% of (B-2) potassium nitrate. Agent composition.   The dentifrice composition according to any one of claims 1 to 4, which is used for anti-inflammation or for improving bad breath. (A) one or more selected from ascorbic acid esters and salts thereof;
(B) The anti-inflammatory agent for oral cavity which consists of aluminum lactate and whose content ratio of (B) component / (A) component is 2-50 by mass ratio.   The anti-inflammatory agent for oral cavity according to claim 6, comprising 0.05 to 2% by mass of component (A) and 1 to 5% by mass of component (B). (A) one or more selected from ascorbic acid esters and salts thereof;
An anti-inflammatory agent for oral cavity comprising (B) (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of component (B) / component (A) is 2 to 50 in terms of mass ratio.   The anti-inflammatory agent for oral cavity according to claim 8, containing 0.05 to 2% by mass of component (A) and 1 to 9% by mass of component (B). The oral cavity according to claim 8, comprising 0.05 to 2% by mass of component (A), 1 to 5% by mass of (B) (B-1) aluminum lactate, and 1 to 8% by mass of (B-2) potassium nitrate. Anti-inflammatory agent. (A) one or more selected from ascorbic acid esters and salts thereof;
(B) The bad breath improving agent which consists of aluminum lactate and whose content ratio of (B) component / (A) component is 2-50 by mass ratio.   The bad breath improving agent according to claim 11, comprising 0.05 to 2% by mass of component (A) and 1 to 5% by mass of component (B). (A) one or more selected from ascorbic acid esters and salts thereof;
(B) A bad breath improving agent comprising (B-1) aluminum lactate and (B-2) potassium nitrate, wherein the content ratio of component (B) / component (A) is 2 to 50 in terms of mass ratio.   The bad breath improving agent according to claim 13, comprising 0.05 to 2% by mass of component (A) and 1 to 9% by mass of component (B).   The malodor of Claim 13 which contains 0.05-2 mass% of (A) component, 1-5 mass% of (B) (B-1) aluminum lactate, and 1-8 mass% of (B-2) potassium nitrate. Improver.