KR20110107327A - Dentifrice composition - Google Patents

Abstract

(A) At least one or more selected from ascorbic acid esters and salts thereof, and (B) aluminum lactate and / or potassium nitrate, wherein the content ratio of (B) component / (A) component is from 2 to mass ratio. A tooth abrasive composition, characterized in that 50.

Description

Tooth Abrasive Composition {DENTIFRICE COMPOSITION}

The present invention is excellent in the effect of suppressing perceptual hypersensitivity, and exhibits the effect of preventing periodontal inflammation and oral cavity removal effect from high periodontal disease, and removes tartar, and has a good feeling of use, resulting from periodontal disease such as perceptual hypersensitivity symptoms and bad breath, inflammation. A tooth abrasive composition effective for inhibiting or preventing the symptoms of

Periodontal disease is a major disease in the oral cavity along with tooth decay and is a disease that accounts for about half of the cause of tooth loss. Most of periodontal disease is considered to be infection caused by bacteria mainly composed of anaerobic Gram-negative bacillus, and as a result, connective tissue and alveolar bone are destroyed. Clinical findings in this process include inflammation, swelling, bleeding, drainage, bad breath, and gum retraction.

In living organisms, neutrophils have the function of sterilizing bacteria and protecting the living body, but particularly in chronic inflammation, they adversely affect biological tissues by leakage of cellular components and production of excess free radicals. Thus, by using antioxidants such as ascorbic acid and derivatives thereof, it is useful to prevent tissue destruction by free radicals. Ascorbic acid ester and its derivatives are mix | blended with a tooth abrasive composition, and it is proposed, for example in patent document 1 etc. that this effect is effective in suppressing bad breath and inflammation resulting from periodontal disease.

In addition, in the case of periodontal disease, gum retraction occurs and the dentin of the root portion is exposed, resulting in symptoms of hypersensitivity.

Dentin perceptual hypersensitivity is defined as transient, very unpleasant pain caused by the dentin of the root and exposing the dentin to some thermal, chemical, or mechanical outward stimulus. The cause of this pain is thought to be that the pulp nerve is stimulated through the exposed ivory tubule.

In the past, numerous studies have been conducted on the prevention and treatment of dentin hypersensitivity. For example, the potassium salt, strontium salt, zinc chloride, aluminum salt, etc. are reported to patent documents 2-5 etc. as an effective component for the prevention and treatment of dentin hypersensitivity. In particular, Patent Document 6 and the like have reported that potassium salt blunts the sensory nerve by relieving sensory nerve activity due to an increase in extracellular potassium ion concentration, and alleviates pain due to hypersensitivity. In addition, Patent Documents 6 and 7 have reported that aluminum salts prevent stimulation from being transmitted to nerves of the pulp by narrowing or occluding the dentinal tubules.

In a state with hypersensitivity symptoms, pain is felt even when teeth are polished, so it is difficult to brush normally, and therefore, it is difficult to remove tartar and to sufficiently remove periodontal causative bacteria, and to maintain oral hygiene. There is a problem that adversely affects, and bad breath derived from periodontal disease is likely to occur. If the pain caused by perceptual hypersensitivity is more effectively alleviated, it is possible to perform brushing more carefully. However, perceptual hypersensitivity inhibiting components, such as aluminum lactate, have a strong bitter taste and have a problem in usability. Until now, although patent documents 8, 9, etc. have described about the improvement of the usability of a perceptual hypersensitivity suppression component compounded tooth abrasive, these effects were not enough. The tooth abrasive compounded with the perceptual hypersensitivity suppressing component has a problem that it is difficult to wipe it carefully for a long time because of its usability.

Therefore, it is excellent in the prevention and treatment effect of the perceptual hypersensitivity symptom, and even the state which has the perceptual hypersensitivity symptom becomes more possible brushing, the tartar removal is enough, the periodontal disease prevention effect is fully exhibited, and the usability is also There is a need for development of good tooth abrasive compositions.

It is also proposed in Patent Document 10 that an oral care composition containing ascorbic acid ester may optionally contain a component for reducing the sensitivity of teeth such as potassium nitrate as an auxiliary active ingredient. However, this technique does not show the use of ascorbic acid ester or its salt, aluminum lactate, and / or potassium nitrate together, nor the content ratio of the positive component, and there is no suggestion of the said subject. From such a technique, it is hard to expect to combine high perceptual hypersensitivity effect, bad breath improvement effect, inflammation suppression effect and tartar removal effect by appropriately using ascorbic acid ester or its salt with aluminum lactate and / or potassium nitrate. .

[Prior Art Literature]

[Patent Document]

Patent Document 1: Japanese Patent Application Laid-Open No. 62-96408

Patent Document 2: Japanese Patent Application Laid-Open No. 61-36212

Patent Document 3: US Patent No. 3863006

Patent Document 4: Japanese Patent Application Laid-Open No. 2006-096696

Patent Document 5: Japanese Patent Application Laid-Open No. 2001-172146

Patent Document 6: Japanese Patent Application Laid-Open No. 8-175943

Patent Document 7: Japanese Patent Application Laid-Open No. 2003-26556

Patent Document 8: Japanese Patent Application Laid-Open No. 2003-73282

Patent Document 9: Japanese Patent Application Laid-Open No. 2001-172146

Patent Document 10: Japanese Patent Application Laid-Open No. 2005-503322

[Non-Patent Documents]

Non-Patent Document 1: Okuda et al., Latest Oral Microbiology (2002) p. 380

The present invention has been made in view of the above circumstances, and is excellent in the effect of suppressing perceptual hypersensitivity symptoms, and can be carefully brushed even if it has perceptual hypersensitivity symptoms, and also has high tartar removal effect, bad breath improvement effect derived from periodontal disease, and inflammation. It is an object of the present invention to provide a tooth polishing composition which exhibits an inhibitory effect, has little bitterness derived from the perceptual hypersensitivity suppressing component, and has a good feeling, and which can effectively suppress symptoms such as bad breath and inflammation derived from periodontal disease. .

MEANS TO SOLVE THE PROBLEM The present inventors earnestly examined in order to achieve the said objective, As a result, (A) at least 1 sort (s) chosen from ascorbic acid ester and its salt, (B) aluminum lactate and / or potassium nitrate, (B) By blending so that the content ratio of the component / (A) component is 2 to 50 in a mass ratio, the positive component acts synergistically, and is excellent in suppressing the hypersensitivity symptoms, and even a user with the hypersensitivity symptom is carefully brushed. As a result, the effect of removing calculus is increased, and the active ingredient penetrates. As a result, a high anti-inflammatory effect is exerted, and the symptoms such as bad breath and inflammation derived from periodontal disease can be effectively suppressed. It turned out that this favorable tooth abrasive composition is obtained.

The tooth abrasive composition of the present invention is derived from the perceptual hypersensitivity inhibiting component by using (A) at least one selected from ascorbic acid esters and salts thereof and (B) aluminum lactate and / or potassium nitrate in a specific ratio. The bitter taste is improved and the feeling is good. At the same time, since the feeling is good, it is possible for the user to carefully brush teeth even more in time, even in use in a state of hypersensitivity symptoms, and the tartar removal effect is more enhanced and expressed ascorbic acid ester or its Since the salt is easy to reach the target site, the ascorbic acid ester or its salts inhibits the inflammation and bad breath due to the inflammation and bad breath of gums and the like caused by periodontal disease satisfactorily. Effective for prevention or inhibition.

In this invention, in the case of (A) component or (B) component mixing | blending alone, or the compounding ratio of a positive component is inappropriate by synergistic action of the positive component by using together (A) component and (B) component in an appropriate ratio. In this case, a special effect that cannot be achieved is obtained. In particular, the above-mentioned effect is that 0.1-1 mass% of (A) component and 2-8 mass% of (B) component are contained, and the content rate of (B) component / (A) component is 4-30 in mass ratio. It is possible to obtain a dental polishing composition which is significantly higher, has excellent perceptual hypersensitivity inhibitory effect, oral inflammation inhibitory effect, bad breath inhibitory effect, and tartar removal effect due to periodontal disease, and has good usability.

Therefore, this invention provides the following tooth abrasive composition.

Claim 1;

(A) At least one or more selected from ascorbic acid esters and salts thereof, and (B) aluminum lactate and / or potassium nitrate, wherein the content ratio of (B) component / (A) component is from 2 to mass ratio. A tooth abrasive composition, characterized in that 50.

Claim 2;

Ascorbic acid ester is ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphate ester, ascorbic acid-2-sulfuric acid ester, ascorbic acid-2-par The tooth abrasive composition of Claim 1 which is 1 or more types chosen from a mitinic acid ester and ascorbic acid 2-stearic acid ester ascorbic acid phosphate ester.

Claim 3;

Ascorbic acid ester is an ascorbic acid phosphate ester, The tooth abrasive composition of Claim 1 characterized by the above-mentioned.

Claim 4;

(A) The component is a sodium salt or magnesium salt of ascorbic acid phosphate ester, The tooth abrasive composition of Claim 1 characterized by the above-mentioned.

Claim 5;

(A) Component contains 0.05-2 mass% and (B) component 1-9 mass%, The tooth abrasive composition of any one of Claims 1-4 characterized by the above-mentioned.

Claim 6;

0.1-1 mass% of (A) component and 2-8 mass% of (B) component are contained, and the content rate of (B) component / (A) component is 4-30 in mass ratio, Claim 1 characterized by the above-mentioned. The tooth abrasive composition of any one of Claims 4-4.

Claim 7;

Moreover, an abrasive | polishing agent, a viscous agent, a caking additive, and surfactant are mix | blended and it is prepared as a soft tooth abrasive | polishing agent, The tooth abrasive composition of any one of Claims 1-6 characterized by the above-mentioned.

Claim 8;

The tooth abrasive composition of any one of Claims 1-7 for suppressing or preventing perceptual hypersensitivity and periodontal disease.

The tooth abrasive composition of the present invention is excellent in the effect of suppressing the perceptual hypersensitivity symptoms, exhibits a high tartar removal effect, bad breath improvement effect and an inflammation inhibitory effect in the oral cavity, has little bitterness derived from the perceptual hypersensitivity suppressing component and has a good feeling of use. In addition, even if the user has perceptual hypersensitivity symptoms, the user can brush the teeth carefully for a long time, and can be effectively used for the prevention and treatment of perceptual hypersensitivity and periodontal disease.

EMBODIMENT OF THE INVENTION Hereinafter, when it demonstrates in detail about this invention, the tooth abrasive composition of this invention contains at least 1 sort (s) chosen from (A) ascorbic acid ester and its salt, and (B) aluminum lactate and / or potassium nitrate. .

Ascorbic acid esters include one or two or more of the hydroxyl groups of any of positions 2, 3, 5, and 6 of ascorbic acid consisting of esters of phosphoric acid, polyphosphoric acid, sulfuric acid, fatty acids, and other pharmaceutically acceptable compounds. Can be used. For example, ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-6-phosphate ester, ascorbic acid-2-polyphosphate ester, ascorbic acid-2-sulphate ester, Ascorbic acid-2-partic acid ester, ascorbic acid-6-partic acid ester, ascorbic acid-2-stearic acid ester, ascorbic acid-6-stearic acid ester, ascorbic acid-2,6-dibutyl Ester, ascorbic acid-2,6-partic acid ester, etc. are mentioned. Examples of such salts include alkali metal salts such as sodium salts, potassium salts, calcium salts and magnesium salts, and alkaline earth metal salts.

These ascorbic acid esters and salts thereof may be contained alone or in combination of two or more thereof. Among the ascorbic acid esters, the hydroxyl group of the second or third position of ascorbic acid is particularly preferable in terms of stability of the composition. Esterified ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphate ester, ascorbic acid-2-sulphate ester, ascorbic acid-2-partic acid ester , Ascorbic acid-2-stearic acid ester and the like are preferably used.

Among the ascorbic acid esters, phosphate esters receive dephosphoric acid by the enzyme phosphatase which is widely present in the living body after being taken in vivo, and act as ascorbic acid, thus preventing bad breath and inflammation derived from periodontal disease. Is excellent and particularly preferred. Among the ascorbic acid phosphate ester salts, magnesium salts and sodium salts are particularly preferable in terms of the effect of inhibiting bad breath and inflammation derived from periodontal disease.

These ascorbic acid esters are commercialized, for example, from Fire Hydrant Co., Ltd., and DSM Nutrition Japan Co., Ltd., and can be obtained.

Ascorbic acid ester and its salt content are preferably 0.05 to 2% (mass% or less), particularly 0.1 to 1%, of the whole composition in terms of the bad breath and inflammation inhibitory effects derived from periodontal disease. When it is less than 0.05%, the bad breath and inflammation inhibitory effect derived from periodontal disease may not be enough, and when it exceeds 2%, a bitter taste may be felt at the time of use, and it may be inferior to a feeling.

Aluminum lactate and potassium nitrate are used as a perceptual hypersensitivity inhibitor, may mix aluminum lactate or potassium nitrate independently, or may use aluminum lactate and potassium nitrate together.

Aluminum lactic acid can use what is marketed from Musashino Chemical Research Institute, for example.

Potassium nitrate can use what is marketed from Otsuka Chemical Co., Ltd., for example.

As for the compounding quantity of aluminum lactate and / or potassium nitrate, 1 to 9% of the whole composition, Preferably 2 to 8% are preferable. If the amount is less than 1%, the effect of suppressing hypersensitivity may not be satisfactorily exhibited, brushing may not be satisfactory, and calculus removal may be insufficient. Not only can an increase be expected, but a bitter taste may occur and it may be inferior to usability.

In addition, the content of aluminum lactate is preferably 1 to 5%, particularly 1 to 3%, of the whole composition in terms of the perceptual hypersensitivity inhibitory effect. If less than 1%, the effect of suppressing hypersensitivity is not satisfactorily exhibited, brushing cannot be satisfied, and calculus removal may be insufficient, and even if it exceeds 5%, an increase in the effect corresponding to the increase in content cannot be expected. Not only that, there is a bitter taste and may be inferior to the feeling.

As for content of potassium nitrate, 1-8% of the whole composition, especially 2-7% are preferable at the point of a perceptual hypersensitivity inhibitory effect. If it is less than 1%, the perceptual hypersensitivity effect is not exhibited satisfactorily, brushing cannot be satisfied, and calculus removal may be insufficient, and if it exceeds 8%, the bitterness is too strong and the feeling of use may be inferior.

In this invention, the content ratio ((B) / (A)) of (A) component and (B) component is 2-50 in mass ratio, Preferably it is 4-30, By setting it as this range, the taste of a composition will be It is good and excellent in use, and also it can obtain high bad breath and anti-inflammation effect, perceptual hypersensitivity effect and tartar removal effect. In addition, by using the above-mentioned blending ratio, the taste is excellent, the feeling of use is excellent, and the pain when brushing can be suppressed. As a result, the prevention effect of bad breath and inflammation derived from periodontal disease, and the dentin hypersensitivity inhibitory effect are increased, and for a long time More elaborate and full brushing is possible, and a higher degree of tartar removal is possible. If the mass ratio is less than 2, sufficient perceptual hypersensitivity effect cannot be obtained, and brushing cannot be satisfied, and calculus removal effect cannot be obtained, and if it exceeds 50, sufficient bad breath and inflammation inhibitory effect is not obtained, and bitter taste is produced It is inferior, and none of them can achieve the effect of this invention.

The tooth abrasive composition of the present invention is prepared in the form of a paste, gel, liquid, liquid, solid, gum, or the like, and is a soft tooth abrasive, a liquid tooth abrasive, a polished tooth abrasive, or a powder. ) Tooth abrasives such as tooth abrasives and liquid tooth abrasives, in particular, are prepared as soft tooth abrasives, and other additives may be blended as optional components in addition to the essential components according to the formulation.

In the case of soft tooth abrasives, for example, an abrasive, a thickening agent, a binder, a surfactant, a sweetener, a preservative, a coloring agent (pigment), a preservative stabilizer, various active ingredients, a fragrance, a solvent, etc. are manufactured by mixing, for example. can do.

As the abrasive, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, aluminum hydroxide, calcium hydrogen phosphate dihydrate and anhydrous salts, calcium pyrophosphate, sodium metaphosphate, hydroxyapatite, heavy and Hard calcium carbonate, zirconium silicate, alumina, magnesium carbonate, magnesium triphosphate, synthetic resin abrasives and the like, but silica abrasives are particularly suitably used. The content of the abrasive is usually 0 to 40%, in particular 2 to 30%.

As a viscous agent, polyhydric alcohol, sugar alcohol, etc. can be used, For example, sorbet, glycerin, ethylene glycol, propylene glycol, 1, 3- butylene glycol, polyethylene glycol, polypropylene glycol , Xylite, maltite, lactite and the like. Content of a viscous agent is 1 to 60% normally.

Examples of the caking agent include cellulose derivatives such as carboxymethyl cellulose sodium, rubbers such as xanthan rubber, tracant rubber, karaya rubber, and arabic rubber, polyvinyl alcohol, cross-linked sodium polyacrylate, and non-crosslinked polyacrylic acid. Organic binders such as carboxyvinyl polymers such as sodium, carrageenan, sodium alginate and polyvinylpyrrolidone; and inorganic binders such as silica gel, aluminum silica gel, gum, and laponite. Content of a caking additive is 2 to 10% of a composition normally.

As surfactant, anionic surfactant, a nonionic surfactant, cationic surfactant, and an amphoteric surfactant can be contained. Examples of the anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinates such as sodium N-lauroyl sarcosinate and sodium N-myristoyl sarcosinate, and dodecylbenzene. N-acyl glutamate, N-methyl-N-acyltaurine sodium, N-methyl-N, such as sodium sulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutarate Sodium acyl alanine, sodium α-olefin sulfonate, and the like. Examples of nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and sucrose fatty acid esters, glycerin fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene glycerin fatty acid esters, and polyethylene glycol fatty acid esters. Polyhydric alcohol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkyl phenyl ethers, ether-type activators such as polyoxyethylene cured himashi oil, lauric acid diethanolamide, and the like. Fatty acid alkanolamides are mentioned. Examples of cationic surfactants include alkylammonium and alkylbenzylammonium salts. Examples of the amphoteric surfactant include betaine acetate, imidazolinium betaine, lecithin and the like.

The blending amount of the surfactant is usually 0 to 15%, especially 0.5 to 10% of the composition.

Spices are peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil , Lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, oligonum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolut peppermint Natural fragrances, such as Absolutrose and orange flowers, and processing of these natural fragrances (current cut, downstream cut, fractionation, liquid extraction, essence, powder fragrance, etc.) ) Fragrance and menthol, carbon, anetol, cineol, methyl salicylate, cinnamicaldehyde, eugenol, 3-l-menthoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene , Menton, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octyl Aldehyde, Citral, Fullegon, Carbitol Acetate, Anisealdehyde, Ethyl Acetate, Ethyl Butyrate, Allylcyclohexanepropionate, Methyl anthranilate, Ethylmethylphenylglycitate, Vanillin, Undecaractone, Hexanal, Propyl Single flavor fragrances, such as alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate, strawberry flavor, Known fragrance materials used in tooth polishing compositions, such as apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and combination flavors such as tropical fruit flavor, can be used.

Moreover, content is not specifically limited, either, It is preferable to use said fragrance raw material 0.000001 to 1% in formulation composition. Moreover, as a fragrance | flavor for fragrance using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in formulation composition.

Examples of the sweeteners include sodium saccharin, stevioside, stevia extract, neohespyridine dihydrochalcone, glycyrrhizin, peraryllatin, p-methoxycinnamicaldehyde, aspartame, xylitol and the like.

Examples of the preservative include palaoxybenzoic acid esters such as butyl paraben, propyl paraben and ethyl paraben, sodium benzoate, cetylpyridinium chloride, isopropylmethylphenol, potassium sorbate and the like.

As a coloring agent, Blue No. 1, Blue No. 4, Green No. 3, etc. are illustrated.

Examples of the storage stabilizer include vitamins such as vitamin E, sulfites such as sodium sulfite, sodium pyrosulfite and sodium hydrogen sulfite, butyl hydroxytoluene, glutamic acid propyl, butyl hydroxyaryl and the like.

As various active ingredients, things other than (A) and (B) component, For example, monofluorophosphates, such as sodium monofluorophosphate, fluorine-containing compounds, such as sodium fluoride, potassium salt of pure phosphoric acid, sodium Water-soluble phosphoric acid compounds such as salts, allantoin, allantoin chlorohydroxyalumium, hinokithiol, sodium chloride, dl-tocopherol acetate, coenzyme Q10, dihydrocholesterol, α-bisabolol, chlorohexidine salts, triclosan, Kinetic thiols, isopropylmethylphenol, acid guirin extract, azulene, glycyrrhizin, copper sirtinic acid, copper chlorophyllin sodium, chlorophyll, glycerol phosphate compounds such as copper compounds, copper compounds such as copper gluconate, strontium chloride, Berberine, hydroxamic acid and derivatives thereof, pyrophosphate, tripolyphosphate, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epi Hydrocholesterine, cecilpyridinium chloride, benzetonium chloride, benzalkonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, dextrase, mutanase, protease, Japanese Angelica root soft extract An effective amount of extracts such as yellowish white extract, dense stalk, sperm, sage, rosemary, golden, benibana and the like can be blended in an effective range without impairing the effects of the present invention.

In addition, content of these arbitrary components can be made into the normal amount in the range which does not prevent the effect of this invention.

The tooth abrasive composition of the present invention is, as an accommodating container, in addition to a tube such as an aluminum laminate tube or a glass vapor-deposited plastic tube, a film packaging container such as a dispenser container or pillow packaging by mechanical or differential pressure, injection, hollow ( It can also fill a bottle by shaping | molding, such as a hollow, press, and a vacuum.

Example

Hereinafter, the present invention will be described in detail by showing experimental examples, examples and comparative examples, but the present invention is not limited to the following examples. In addition, in the following example, all compounding quantities are the mass%.

[Example, Comparative Example]

The tooth abrasive composition (soft tooth polishing) of the composition shown to Tables 1-4 was prepared by a routine method, and the following experiment was performed and evaluated. The results are shown in Tables 1-4.

As each component used for preparation of these tooth abrasive compositions, ascorbic acid 2-phosphate ester magnesium (ascorbic acid PM, the fire hydrant), sodium ascorbic acid 2-phosphate ester (stay C-50, DSM New) Using torsion Japan), ascorbic acid-2-sulfuric acid ester (made by ITO), aluminum lactate (made by Musashino Chemical Research Institute), potassium nitrate (made by Otsuka Chemical Co., Ltd.) In addition, precipitated silica, sodium hydroxide, thickening silica, carboxymethyl cellulose, sodium lauryl sulfate, sodium monofluorophosphate, sorbite, silicic anhydride, propylene glycol, sodium saccharin, and water are based on old cosmetic raw material standards. Or quasi-drug quality standard 2006 was used. As for the sorbet, a tooth polishing composition was prepared using a 70% aqueous solution.

Experimental Example 1 Evaluation of Bad Breath Improvement Rate from Periodontal Disease

Evaluation was performed using ten volunteer subjects with symptoms of perceptual hypersensitivity, subjective symptoms of periodontal disease (swelling and bleeding of gums), and bad breath. First, oral cleaning was stopped by the subject for 1 day, and 1L of breath exhaled in a fluorine resin sampling container (Todorabagu N type 1L size, manufactured by Sampler Tech Co., Ltd.) was collected. The level of bad breath was evaluated, and the grade was set to S1.

Next, 1 g of the test tooth abrasive was used once, twice a day, and then used for 1 month by a conventional method (brushing teeth using a toothbrush for 3 minutes), and then, oral cleaning was stopped for 1 day, and the fluorine resin 1 L of breath breathed in a sampling container (Todora Ward N type 1 L size, product made by Sampler Tech Co., Ltd.) was extract | collected, and the steering wheel 10 evaluated the level of bad breath derived from periodontal disease according to the evaluation criteria mentioned later, and the rating was set to S2.

The improvement of the bad breath derived from periodontal disease of each subject was computed according to following Formula, and the average value of 10 subjects was calculated | required. This average value was determined according to the criteria described later.

Improvement == S1-S2 of bad breath derived from periodontal disease

<Evaluation Criteria>

5: There is bad breath derived from extremely strong periodontal disease.

4: There is bad breath derived from strong periodontal disease.

3: There is bad breath derived from periodontal disease slightly.

2: There is bad breath derived from a periodontal disease.

1: Almost no bad breath derived from periodontal disease.

0: There is no bad breath from periodontal disease.

<Judge criteria>

◎: 3.5 or more and 5 or less

○: 2.5 or more and less than 3.5

(Triangle | delta): 1 or more and less than 2.5 points

×: less than 1 point

Experimental Example 2 Evaluation of Usability

Each tooth dentition is used for 10 persons with symptoms of dentin hypersensitivity to 1 g of the test tooth abrasive once, and then used for 3 minutes in a conventional manner (brushing teeth for 3 minutes using a toothbrush). Sensual feelings such as bitter taste were evaluated by the following criteria, and the average of 10 people was obtained. This average value was determined according to the criteria described later.

<Evaluation Criteria>

4: I do not feel bitter taste at all, the feeling is very good.

3: hardly feel bitterness, there is no problem in feeling.

2: I feel a weak bitter taste and there is a problem with usability a little.

1: strong feeling of bitterness, can not withstand use.

<Judge criteria>

◎: 3.5 or more and 4 or less

○: 3 or more and less than 3.5

△: 2 or more and less than 3 points

×: less than 2 points

Experimental Example 3 Evaluation of Perceptual Hypersensitivity Inhibitory Effect

Each tooth dentition was used once 10 g of the test tooth abrasive to 10 people with symptoms of dentin perceptual hypersensitivity, and used for 5 minutes by a conventional method (brushing the tooth for 5 minutes using a toothbrush), and pain at that time. Was evaluated by the following criteria and the average of 10 people was calculated | required. This average value was determined according to the criteria described later.

<Evaluation Criteria>

4: The tooth can be brushed for 5 minutes without feeling pain at all.

3: Level which feels a slight pain but can brush teeth for 3 minutes, and there is no problem.

2: I feel a little pain, but I can brush my teeth for 1 minute.

1: The pain is strongly felt and the tooth cannot be brushed for 1 minute.

<Judge criteria>

◎: 3.5 or more and 4 or less

○: 3 or more and less than 3.5

△: 2 or more and less than 3 points

×: less than 2 points

Experimental Example 4 Evaluation of Tartar Removal Effect

Non-patent literature after each tooth removal was used 1 g of the test tooth abrasive once for 10 people with symptoms of dentin hypersensitivity, and used for 3 minutes (brushing the teeth for 3 minutes using a toothbrush) by a conventional method. Tartar stained by calculus according to the method of 1, and stained on four tooth surfaces (myocardium, centrifugal heart, lip side, tongue side) of each subject at that time This was attached and the PI (Plaque Index) was calculated by the following formula. The average PI of ten subjects was determined according to the criteria mentioned later.

PI (%) = ((total of tooth surface attached to tartar) / (number of test teeth surface)) * 100

<Evaluation Criteria>

4: less than 25%

3: 25% or more but less than 45%

2: 45% or more and less than 75%

1: over 75%

<Judge criteria>

◎: 3.5 or more and 4 or less

○: 3 or more and less than 3.5

△: 2 or more and less than 3 points

×: less than 2 points

Experimental Example 5 Evaluation of Inhibition of Inflammation

Inflammation was caused by a burn on the hamster cheek pouch, and about 0.1 g of the sample (the tooth polishing composition) was applied onto the porch. The porch was removed after 5 hours. The mass of the porch was measured, and the edema inhibition rate was calculated from the mass difference with the untreated site (opposite porch). This was done for 8 samples, and the average edema inhibition rate (%) with respect to an untreated site | part was computed, and the following reference | standard determined.

Average edema inhibition rate (%)

= 100-((mass of untreated site-mass of sample coated site) / (mass of untreated site)) × 100

<Judge criteria>

◎: average edema inhibition rate 20% or more

○: Average edema inhibition rate is 10% or more but less than 20%

△: average edema inhibition rate is 5% or more but less than 10%

X: average edema inhibition rate is less than 5%

*: Sodium L-ascorbate: Fuso Chemical Industry Co., Ltd.

From the results of Tables 1 to 4, when one of the components (A) and (B) according to the present invention is in an unsuitable composition or a composition in which the mass ratio of (B) / (A) is inadequate, the bad breath-improving effect derived from periodontal disease and the feeling of use Inferior to the perceptual hypersensitivity effect, tartar removal effect, and inflammation inhibitory effect, and the satisfactory effect was not exhibited. On the other hand, it was confirmed that the tooth abrasive composition of this invention is excellent in the bad breath improvement effect, perceptual hypersensitivity effect, the tartar removal effect, and the inflammation inhibitory effect derived from periodontal disease, and it is a favorable taste without a bitter taste and excellent in usability.

Next, the tooth abrasive composition of the following composition was prepared similarly to the above, and evaluated similarly.

Example 19 Liquid Tooth Abrasive

Silicic anhydride 10.0%

Xanthan Rubber 1.0

Saccharin Sodium 0.1

70% Sorbit Liquid 35.0

Glycerin 20.0

Propylene Glycol 3.0

Sodium Lauryl Sulfate 1.2

Sodium Hydrogen Carbonate 2.0

Lauric acid decaglyceryl0.5

Sodium Monofluorophosphate 0.73

Potassium Nitrate 5.0

Ascorbic Acid-2-Magnesium Phosphate 0.5

Sodium Hydroxide 0.4

Spices 0.8

Blue No. 1 0.001

Purified water                                            Remainder

Total 100.0%

(B) / (A) = 10.0

The evaluation result is as follows.

Bad breath improvement rate derived from periodontal disease ◎

◎ feeling

◎ hypersensitivity inhibitory effect

Tartar removal effect ◎

◎ anti-inflammatory effect

In addition, the same result was obtained when aluminum lactate was used instead of potassium nitrate. In addition, the same result was obtained when sodium ascorbic acid-2-phosphate was used instead of ascorbic acid 2-phosphate magnesium.

Example 20 Liquid Tooth Abrasive

Silicic anhydride 10.0%

Xanthan Rubber 1.0

Saccharin Sodium 0.1

70% Sorbit Liquid 35.0

Glycerin 20.0

Propylene Glycol 3.0

Sodium Lauryl Sulfate 1.2

Sodium Hydrogen Carbonate 2.0

Lauric acid decaglyceryl0.5

Sodium Monofluorophosphate 0.73

Potassium Nitrate 4.0

Ascorbic Acid-2-Magnesium Phosphate 0.2

Sodium Hydroxide 0.4

Spices 0.8

Blue No. 1 0.001

Purified water                                            Remainder

Total 100.0%

(B) / (A) = 20.0

The evaluation result is as follows.

Bad breath improvement rate derived from periodontal disease ◎

◎ feeling

◎ hypersensitivity inhibitory effect

Tartar removal effect ◎

◎ anti-inflammatory effect

In addition, the same result was obtained when aluminum lactate was used instead of potassium nitrate. In addition, the same result was obtained when sodium ascorbic acid-2-phosphate was used instead of ascorbic acid 2-phosphate magnesium.

Claims (8)

(A) At least one or more selected from ascorbic acid esters and salts thereof, and (B) aluminum lactate and / or potassium nitrate, wherein the content ratio of (B) component / (A) component is from 2 to mass ratio. A tooth abrasive composition, characterized in that 50. The method of claim 1,
Ascorbic acid ester is ascorbic acid-2-phosphate ester, ascorbic acid-3-phosphate ester, ascorbic acid-2-polyphosphate ester, ascorbic acid-2-sulfuric acid ester, ascorbic acid-2-par A tooth abrasive composition, characterized in that it is at least one member selected from mitic acid ester and ascorbic acid-2-stearic acid ester ascorbic acid phosphate ester. The method of claim 1,
Ascorbic acid ester is an ascorbic acid phosphate ester, The tooth abrasive composition characterized by the above-mentioned. The method of claim 1,
(A) A component is a tooth polishing composition characterized by the sodium salt or magnesium salt of ascorbic acid phosphate ester. The method according to any one of claims 1 to 4,
The tooth abrasive composition containing 0.05-2 mass% of (A) component, and 1-9 mass% of (B) component. The method according to any one of claims 1 to 4,
0.1-1 mass% of (A) component, 2-8 mass% of (B) component, and the content rate of (B) component / (A) component are 4-30 in mass ratio, The tooth abrasive composition characterized by the above-mentioned. . The method according to any one of claims 1 to 6,
Moreover, an abrasive | polishing agent, a viscous agent, a caking additive, and surfactant are mix | blended and it is prepared as a soft tooth abrasive | polishing agent, The tooth abrasive composition characterized by the above-mentioned. The method according to any one of claims 1 to 7,
Tooth abrasive composition, characterized in that for suppressing or preventing perceptual hypersensitivity and periodontal disease.