201034697 六、發明說明： 【發明所屬之技術領域】 本發明係有關具優異的抑制牙齒敏感效果，且可發揮 極高的預防起因於牙周病之口臭•口腔內發炎效果及去除 齒垢效果，使用感佳，可有效的抑制或預防牙齒敏感症狀 與口臭•發炎等起因於牙周病之症狀之潔牙劑組成物。 Q 【先前技術】 牙周病與齲齒並列口腔內2大疾病，約佔損失牙齒原 因之一半以上。一般認爲牙周病大多係因感染主要爲兼性 厭氣性革蘭氏陰性桿菌之細菌而引起之感染症，其結果是 破壞結締組織與齒槽骨。其病程於臨床上可見爲發炎、腫 脹、出血、排膿、口臭，牙齦萎縮等。 體內的嗜中性白血球具有殺死細菌、防禦人體之功能 ，但特別在慢性發炎反應時，因其所釋出之細胞成分及所 Q 產生之過剩的活性氧，對人體組織反而造成不良影響。對 此，藉由使用如抗壞血酸及其衍生物之抗氧化劑，可有效 防止活性氧對組織的破壞。專利文件1已提案於潔牙劑組 成物中混合抗壞血酸酯及其衍生物，可有效抑制起因於牙 周病之口臭·發炎。 進而於患有牙周病時，會引起牙齦萎縮，露出牙齒根 部的象牙質，結果有時會造成出現牙齒敏感症狀。 象牙質牙齒敏感症被定義爲牙齒根部的象牙質露出， 由於象牙質受到冷熱、化學性、機械性等的外來刺激，產 -5- 201034697 生了短暫的非常不愉快的疼痛。一般認爲該疼痛的原因係 經由暴露出的象牙小管而使齒髓神經受到刺激。 以往已進行了相當多的有關預防及治療象牙質牙齒敏 感症之硏究。例如專利文件2〜5已報告了可作爲預防及 治療象牙質牙齒敏感症有效成分之鉀鹽、緦鹽、氯化鋅、 鋁鹽等。特別於專利文件6等報告了可藉由鉀鹽使細胞外 鉀離子濃度增加而降低感覺神經活性，使感覺神經麻鈍， 而可緩和因神經敏感而造成的疼痛。另外專利文件6、7 等報告了可藉由鋁鹽使象牙小管變窄或閉塞，而可防止刺 激傳達至齒髓的神經。 當有牙齒敏感症狀，因刷牙時會感到疼痛，而難以進 行一般性的刷牙，因此變得難以充分地去除齒垢及引起牙 周病之病原菌，另外會對維持口腔衛生有不良的影響，而 容易產生起因於牙周病之口臭問題。若可有效的緩和因牙 齒敏感而造成的疼痛，則可更仔細地實施刷牙步驟。然而 ，乳酸鋁等牙齒敏感抑制成分具極強苦味，有使用感的問 題。至今雖於專利文件8、9等有針對改善混合牙齒敏感 抑制成分潔牙劑之使用感的記載，但該等之效果並不充分 。經混合牙齒敏感抑制成分之潔牙劑，有因爲使用感而難 以長時間仔細進行刷牙此一課題。 因此，目前正期待開發具優異的預防及治療牙齒敏感 效果，即便於有牙齒敏感症狀的狀態下’亦可更仔細地進 行刷牙步驟，充分去除齒垢，並充分發揮牙周病預防效果 ，且使用性亦良好的潔牙劑組成物。 -6 - 201034697 另外於含抗壞血酸酯之口腔照護組成物，專利文件 10提案，由於輔助有效成分之硝酸鉀等爲可降低牙齒敏 感性之成分，可任意地進行混合。但於該技術中，並未標 示抗壞血酸酯或其鹽，與乳酸鋁及/或硝酸鉀倂用時之二 成分之含有比例，亦無有關上述課題之暗示。而由該技術 ，亦難以預期適當地倂用抗壞血酸酯或其鹽與乳酸鋁及/ 或硝酸鉀，可以獲得兼具有更高的抑制牙齒敏感效果、改 0 善口臭效果、抑制發炎效果及去除齒垢效果。 先前技術文件 專利文件 專利文件1 :特開昭62-96408號公報 專利文件2 :特開昭6 1 _3 62 1 2號公報 專利文件3 :美國專利第3 8 63 006號說明書 專利文件4 :特開2 006-096696號公報 專利文件5 :特開200 1 - 1 72 1 46號公報 Q 專利文件6 :特開平8- 1 75943號公報 專利文件7 :特開2003-26556號公報 專利文件8 :特開2003 -73 282號公報 專利文件9 ··特開2〇〇1 - 1 72 1 46號公報 專利文件10 :特表2005 -5 03 3 22號公報 非專利文件 非專利文件1 :奧田等，最新口腔微生物學（ 2002 年）p. 380 201034697 【發明內容】 [發明欲解決之課題] 本發明有鑑於上述現狀，以提供具優異的抑制牙齒敏 感效果，且即便於有牙齒敏感症狀的狀態下，亦可仔細地 進行刷牙步驟，及具高齒垢去除效果，並發揮改善起因於 牙周病之口臭之效果及抑制發炎之效果，進而減少來自牙 齒敏感抑制成分之苦味之使用感佳，且可有效抑制起因於 牙周病之口臭•發炎等症狀之效果的潔牙劑組成物爲目的 [解決課題之手段] 本發明之發明者們爲達成上述目的進行專心檢討後， 發現藉由使其含有（A)至少一種以上選自抗壞血酸酯及 其鹽’與（B)乳酸鋁及/或硝酸鉀，且使（B)成分/ (A )成分之含有比率係質量比爲2〜50之方式進行混合，可 獲得二成分產生相乘作用，具優異的抑制牙齒敏感效果， 且即便爲有牙齒敏感症狀的使用者，亦可仔細地進行刷牙 步驟’藉此提高齒垢去除效果，且由於有效成分的浸透， 可發揮極高的抑制發炎之效果，能有效抑制起因於牙周病 之口臭•發炎等症狀，幾乎沒有苦味之使用感佳的潔牙劑 組成物。 本發明之潔牙劑組成物係藉由將（A )至少一種以上 選自抗壞血酸酯及其鹽，與（B )乳酸鋁及/或硝酸鉀，以 特定比例倂用，使來自牙齒敏感抑制成分之苦味被改善而 -8- 201034697 具良好的使用感。另外於此同時，發現由於具有良好的使 用感’即便於有牙齒敏感症狀的狀態下使用，使用者亦可 花更長的時間仔細地進行刷牙步驟而更加強齒垢去除效果 ’且由於使得抗壞血酸酯或其鹽更容易到達標的部位，發 現對起因於牙周病之牙齦發炎及口臭，抗壞血酸酯或其鹽 可對抑制發炎及口臭獲得令人滿意的效果，有效預防或抑 制牙齒敏感及牙周病。 0 於本發明中，可藉由將（A)成分與（B)成分以適 當的比例進行倂用，藉由二成分之相乘作用，可獲得單獨 使用（A )成分或（B )成分，或以不當的比例倂用二成 分所無法達成之效果。特別係使其含有（A)成分0.1〜1 質量％ ’ （B)成分2〜8質量％， （B)成分/ (A)成分 之含有比率係質量比爲4〜3 0，可獲得較前述更高效果， 具優異的抑制牙齒敏感效果，抑制起因於牙周病之口腔內 發炎效果及抑制口臭效果，兼具去除齒垢效果使用感佳的 Q 潔牙劑組成物。 因此本發明係提供下述之潔牙劑組成物。 申請項1 : 一種潔牙劑組成物，其特徵係含有（A)至少一種以 上選自抗壞血酸酯及其鹽，與（B)乳酸鋁及/或硝酸鉀， 且（B)成分/ (A)成分之含有比率係質量比爲2〜50。 申請項2 : 如申請項1之潔牙劑組成物，其中抗壞血酸酯係選自 抗壞血酸-2-磷酸酯、抗壞血酸-3-磷酸酯、抗壞血酸-2-聚 -9 - 201034697 磷酸酯、抗壞血酸-2-硫酸酯、抗壞血酸-2-棕櫚酸酯、抗 壞血酸-2 -硬酯酸酯抗壞血酸磷酸酯之至少一種以上。 申請項3 ·_ 如申請項1之潔牙劑組成物，其中抗壞血酸酯係抗壞 血酸磷酸酯。 申請項4 : 如申請項1之潔牙劑組成物，其中（A )成分係抗壞 血酸磷酸酯之鈉鹽或鎂鹽。 申請項5 : 如申請項1至4中任一項之潔牙劑組成物，其中係含 有（A)成分爲0.05〜2質量％，及（B)成分爲1〜9質 量％。 申請項6 : 如申請1項至4中任一項之潔牙劑組成物，其中係含 有（A)成分爲0.1〜1質量％，及（B)成分爲2〜8質量 %，且（B)成分/ (A)成分之含有比率係質量比爲4〜3〇 〇 申請項7 ’· 如申請項1至6中任一項之潔牙劑組成物，其中係進 而搭配硏磨劑、黏稠劑、黏結劑、界面活性劑，而調製爲 牙膏。 申請項8 : 如申請項1至7中任一項之潔牙劑組成物，其係爲了 抑制或預防牙齒敏感或牙周病者。 -10- 201034697 [發明效果] 本發明之潔牙劑組成物，係具優異的抑制牙齒敏感效 果，且具高齒垢去除效果，可發揮口臭改善效果及抑制口 腔內發炎效果，幾乎沒有來自牙齒敏感抑制成分之苦味而 具良好的使用感，即便爲有牙齒敏感症狀的使用者，亦長 時間地仔細地進行刷牙步驟，可有效的使用於爲了預防及 0 治療牙齒敏感症及牙周病。 以下針對本發明進行詳細地說明，本發明之潔牙劑組 成物係含有（A )至少一種以上選自抗壞血酸酯及其鹽， 與（B )乳酸鋁及/或硝酸鉀。 抗壞血酸酯係可使用與於抗壞血酸之第2、3、5、6 之任一位置上之1個或2個以上之羥基形成磷酸、聚磷酸 、硫酸、脂肪酸、其他藥學上所容許之化合物之酯者。例 如可舉出抗壞血酸-2-磷酸酯、抗壞血酸-3-磷酸酯、抗壞 〇 血酸-6-磷酸酯、抗壞血酸-2-聚磷酸酯、抗壞血酸-2-硫酸 酯、抗壞血酸-2-棕櫚酸酯、抗壞血酸-6-棕櫚酸酯、抗壞 血酸-2 -硬酯酸酯、抗壞血酸-6 -硬酯酸酯、抗壞血酸-2,6-二丁基酯、抗壞血酸-2，6-硬酯酸酯等。另外該等之鹽類可 舉出例如鈉鹽、鉀鹽、鈣鹽、鎂鹽等鹼金屬鹽、鹼土類金 屬鹽等。 該等抗壞血酸酯及其鹽，可使其含有爲單獨1種或2 種以上組合，而抗壞血酸酯中特別於組成物之安定性，以 使用抗壞血酸之第2或第3位置上之羥基被酯化之抗壞血 -11 - 201034697 酸-2-磷酸酯、抗壞血酸-3-磷酸酯、抗壞血酸-2-聚磷酸酯 、抗壞血酸-2-硫酸酯、抗壞血酸-2-棕櫚酸酯、抗壞血酸-2-硬酯酸酯爲佳。 而在抗壞血酸酯中又以磷酸酯因於人體內被吸收後， 會受到廣泛存在於人體內之酵素磷酸酵素作用而脫去磷酸 ，以抗壞血酸之形式進行作用，而對起因於牙周病之口臭 •發炎具優異的抑制效果，而爲特佳。抗壞血酸磷酸酯鹽 中，於對起因於牙周病之口臭•發炎具抑制效果此點之鹽 以鎂鹽、鈉鹽爲佳。 該等抗壞血酸酯類有例如昭和電工股份有限公司及 DSM Nutritional Products日本公司之商品可購買。 抗壞血酸酯及其鹽之含量由對起因於牙周病之口臭· 發炎之抑制效果此點，以組成物全體之〇.〇5〜2% (質量％ ，以下相同）爲佳，特別以0.1〜1%爲佳，未滿0.05%時 對起因於牙周病之口臭•發炎之抑制效果不充分，超過 2%則於使用時會感覺到苦味，會出現使用感不佳之情形 〇 可將乳酸鋁及硝酸鉀使用爲牙齒敏感抑制劑，可將乳 酸鋁或硝酸鉀進行單獨混合，或亦可將乳酸鋁及硝酸鉀合 倂使用。 乳酸鋁可使用例如來自武藏野化學硏究所所發售者。 硝酸鉀可使用例如來自大塚化學（股份有限）所發售 者。 乳酸鋁及/或硝酸鉀之混合量以合計爲組成全體之1〜 -12- 201034697 9 %爲佳，且希望爲2〜8 %。混合量未滿1 %時會出現無法 充分發揮牙齒敏感抑制效果，及無法發揮潔牙效果而不能 夠充分去除齒垢之情形’超過9%時不僅未能達到增加含 量帶來所預期的增加效果’反而會出現產生苦味，使用感 不佳之情形。 進而乳酸鋁之含量自使用爲牙齒敏感抑制劑效果之觀 點而言，以組成全體之1〜5%爲佳，特別爲1〜3%爲佳。 Q 未滿1 %時會出現無法充分發揮牙齒敏感抑制效果，及無 法發揮潔牙效果而不能夠充分去除齒垢之情形，超過5 % 時不僅未能達到增加含量帶來所預期的增加效果，反而會 出現產生苦味，使用感不佳之情形。 硝酸鉀之含量自使用爲牙齒敏感抑制劑效果之觀點而 言，以組成全體之1〜8%爲佳，特別爲2〜7%爲佳。未滿 1 %時會出現無法充分發揮牙齒敏感抑制效果，及無法發 揮潔牙效果而不能夠充分去除齒垢之情形，超過8%時會 Q 出現苦味過強，使用感不佳之情形。 本發明中，（A)成分與（B)成分之含有比率（（B )/ ( A ))係質量比爲2〜50爲佳，4〜30更佳，就由將 範圍設定於此，可獲得組成物風味良好使用感佳，且口臭 * 口腔內發炎抑制效果佳，抑制牙齒敏感效果及去除齒垢 效果。進而藉由上述混合比例，可得到風味良好使用感佳 ，抑制刷牙時疼痛之效果，提高對起因於牙周病之口臭· 發炎之預防效果及象牙質敏感之抑制效果，使使用者可長 時間地仔細地進行刷牙步驟，而可更高度地去除齒垢。質 -13- 201034697 量比未達2時’無法獲得充分的牙齒過敏緩和效果，且由 於無法進行完整的刷牙步驟，而無法獲得去除齒垢效果， 超過50時無法獲得充分的口臭•發炎之抑制效果，產生 苦味’使.用感不佳’無論如何亦無法達成本發明之作用效 果。 本發明之潔牙劑組成物可調製爲膏狀、凝膠狀、液狀 、液體、固體狀、口香糖狀等形狀’再被調製爲牙膏、液 狀牙膏、潤製牙膏、粉狀牙膏、液體牙膏等牙膏，特別係 可調製爲牙膏，且可因應其劑型混合上述必須成分之外的 任意成分爲其他添加劑。 製作爲牙膏時’可與硏磨劑、黏稠劑、黏結劑、界面 活性劑’及因應需要之甜味劑、防腐劑、著色劑（色素） 、保存安定化劑、各種有效成分、香料、溶劑等成分進行 混合而製造。 使用之硏磨劑可舉出沉殺性二氧化砂、二氧化政凝膠 、鋁矽酸矽鹽、锆矽化物等二氧化矽系硏磨劑，氫氧化銘 、磷酸二氫鈣鹽及無水鹽、酸性焦磷酸鈣、六偏磷酸鈉、 羥磷灰石、重質及輕質碳酸鈣、矽酸锆、礬土、碳酸鎂、 磷酸三鎂、合成樹脂系硏磨劑等’但以二氧化砂系硏磨劑 最爲適用。硏磨劑之含量一般以〇〜4〇%爲佳，2〜30。/。更 佳。 黏稠劑可使用多元醇、糖醇等’例如可含有山梨糖醇 、甘油、乙二醇、丙二醇、1，3-丁二醇、聚乙二醇、聚丙 二醇、木糖醇、還原麥牙糖、速原乳糖等。黏稠劑含量一 -14- 201034697 般爲1〜60%。 黏結劑可舉出羧基甲基纖維素鈉等纖維素衍生物、三 仙膠、黃耆膠、卡拉牙膠、阿拉伯膠等膠類、聚乙烯醇、 交聯型聚丙烯酸鈉、非交聯型聚丙烯酸鈉等羧丙烯聚合物 、鹿角菜膠、海藻酸鈉、聚乙烯吡咯烷酮等有機系黏結劑 、二氧化矽凝膠、鋁矽酸矽凝膠、晴奧膠、合成鋰皂石等 無機系黏結劑。黏結劑含量一般爲組成物之2〜1 0%。 0 界面活性劑可使其含有陰離子性界面活性劑、非離子 性界面活性劑、及陽離子性界面活性劑、兩性界面活性劑 。陰離子性界面活性劑可舉出爲十二烷基硫酸鈉、十四烷 基硫酸鈉等烷基硫酸鈉、N-十二醯基肌酸鈉、N-十四醯基 肌酸鈉等N-醯基肌酸鈉、十二基苯磺酸鈉、加氫椰子脂 肪酸單乙二醇酯單硫酸鈉、十二烷基磺醋酸鈉、N-十六醯 基麩胺酸鈉等N-醯基麩胺酸鹽、N-甲基-N-醯基牛磺酸鈉 、N-甲基-N-醯基丙胺酸鈉、α -烯烴磺酸鈉等。非離子性 Q 界面活性劑可舉出脂肪酸山梨醇酐酯、聚氧乙烯脂肪酸山 梨醇酐酯、蔗糖脂肪酸酯等糖醇脂肪酸酯類、乙二醇脂肪 酸酯、聚乙二醇脂肪酸酯、聚氧乙烯乙二醇脂肪酸酯、聚 乙烯乙二醇脂肪酸酯等多元醇脂肪酸酯、聚氧乙烯烷基醚 、聚氧乙烯聚氧丙烯共聚合物、聚氧乙烯烷基苯基醚、聚 氧乙烯氫化篦麻油等醚型活性劑、月桂酸二乙醇醯胺等脂 肪酸烷醇醯胺類。陽離子性界面活性劑可舉出烷基銨、烷 基苯基銨鹽等。兩性界面活性劑可舉出醋酸甜菜鹼、咪唑 啉甜菜鹼、卵磷脂等。 -15- 201034697 界面活性劑之混合量一般爲組成物之〇〜1 5 %爲佳， 以0.5〜1 0 %更佳。 香料可舉出糊椒薄荷油、綠薄荷油、洋茴香油、尤加 利油、冬青油、桂皮油、丁香油、百里香油、鼠尾草油、 檸檬油、柑橘油、薄荷油、蓃蔻油、芄荽油、橘皮油、萊 姆油、薰衣草油 '迷迭香油、月桂樹油、洋甘菊油、香旱 芹子油、馬鬱蘭油、月桂油、檸檬草油、牛至屬油、矮松 針油、橙花油、玫瑰油、茉莉花油、香根鳶尾 '糊椒薄荷 精油、玫瑰精油、橙花等天然香料，及將該等天然香料經 加工處理（前蒸飽部段、後蒸飽部段 '分飽、液液萃取、 萃取化、粉末香料化）後之香料，及薄荷腦、香芹酮、茴 香腦、桉油酚、甲基水揚酸、肉桂醛、丁香酚、3-1-薄荷 氧基丙基-1,2-二醇、麝香草酣、芳樟醇 '乙酸丙嫌醋、檸 檬油精、薄荷酮、乙酸薄荷酯、N -取代-對薄荷院-3-羧酿 胺、蒎烯、辛醒、枸櫞酸 '長葉薄荷酮、醋酸醋、茴香醛 、乙酸乙酯、乙基丁酯、丙烯基環己醇丙酸酯、胺基苯甲 酸甲酯、甲基苯環氧丙酸乙酯、香蘭素、十一酸內酯、己 醛、丙醇、丁醇、異戊醇、己醇、二甲基硫、環苯丁烯、 糠醛、三甲基吡嗪、乳酸乙酯、乳酸甲酯、硫代乙酸乙酯 等單品香料。進而爲草莓香料、蘋果香料、香蕉香料、鳳 梨香料、葡萄香料、芒果香料、牛油香料、牛乳香料、綜 合水果香料、熱帶水果香料等調合香料等，可使用用於潔 牙劑組成物之周知之香料素材。 另外並未特別限定含量，但前述之香料素材以使用量 -16- 201034697 爲製劑組成之0.000001〜1 %爲佳。另外，使用上述香料 素材後之賦香用香料，以使用量爲製劑組成之0.1〜2.0% 爲佳。 甜味料可舉出糖精鈉、甜菊糖苷、甜菊萃取物、新橙 皮苷二氫查耳酮、甘草、紫蘇糖、對甲氧基肉桂醛、阿斯 巴甜、木糖醇等。 防腐劑可舉出對羥基苯甲酸丁酯、對羥基苯甲酸丙酯 0 、對羥基苯甲酸乙酯等對氧基安息酸酯、安息香酸鈉、西 吡氯銨、異丙基甲基苯、己二烯酸鉀等。 著色劑可舉出例如藍色1號、藍色4、綠色3號等。 保存安定化劑可舉出維他命E等維他命類、亞硫酸鈉 、重亞硫酸鈉、亞硫酸氫鈉等亞硫酸鹽、丁基羥基甲苯、 沒食子酸丙酯、丁基羥基甲氧苯等。 各種有效成分係除了（ A )及（B )成分以外者，例 如可舉出單氟磷酸鈉等單氟磷酸鹽、氟化鈉等含氟化合物 Q 、正磷酸之鉀鹽、鈉鹽等水溶性磷酸化合物、尿囊素、尿 囊素氫氯酸鋁、扁柏油酚、氯化鈉、dl-生育酚、輔酶 Q10、二氫膽固醇、沒藥醇、氯己定鹽類、三氯新、扁 柏油酚、異丙基甲基苯、血根鹼萃取物、甘菊環、甘草、 甘草次酸、葉綠素銅鈉、葉綠素、甘油磷酸酯等螯合性磷 酸化合物、葡糖酸銅等銅化合物、氯化緦、鹽酸黃連素、 氫氧胺酸及其衍生物、焦磷酸鹽、三聚磷酸鹽、沸石、乙 烯基甲基醚、無水馬來酸共聚合物、聚乙烯吡咯烷酮、表 二氫腦甾醇、西吡氯銨、甲苄索氯銨、氯化苯二甲羥銨、 -17- 201034697 氯化鈉、二氫膽固醇、三氯對稱二苯脲、檸檬酸鋅、葡萄 聚糖酶、葡聚醣變構水解酶、蛋白酶、白芷萃取物、黃蘖 萃取物、德國洋甘菊、丁香、迷迭香、黃芩、紅花等萃取 物等等，於不妨礙本發明效果之範圍內以有效量進行混合 〇 進而該等任一種成分之含量，於不妨礙本發明效果之 範圍內可使用一般量進行添加。 本發明之潔牙劑組成物之收藏容器除鋁防水層疊軟管 、玻璃沉積塑膠軟管等軟管之外，亦可使用機械性或壓力 差所製成之拋棄式容器、枕袋式包裝等薄膜包裝容器，亦 可藉由射出、中空、擠壓、真空等成形方式塡充於瓶等之 中。 【實施方式】 [實施例] 以下以實驗例、實施例及比較例具體說明本發明，但 本發明並未被限定於下述實施例。另外下述例中混合量的 單位均爲質量％。 [實施例、比較例] 根據常法調製表1〜4所示組成之潔牙劑組成物（牙 膏）’以下述實驗進行評價。結果示於表1〜4。 該等潔牙劑組成物調製時所使用的各成分係抗壞血 酸-2 -磷酸酯鎂（抗壞血酸p Μ，昭和電工股份有限公司製 -18- 201034697 )，抗壞血酸-2-磷酸酯鈉 （SUTEI C-50， Nutritional Products日本公司製），抗壞血酸-2-硫 ((股份有限）ITO製），乳酸鋁（（股份有限）武 化學硏究所製），硝酸鉀（大塚化學（股份有限）製 其他如沉澱性二氧化矽、氫氧化鈉、增黏性二氧化矽 基甲基纖維素、十二烷基硫酸鈉、單氟磷酸鈉、山梨 無水矽酸、丙二醇、糖精鈉及水等係使用合於舊化妝 0 料基準（妝原基）或類藥品原料規格2006者。山梨 使用70%水溶液品，進行調製潔牙劑組成物。 [實驗例1]起因於牙周病之口臭之改善率評價 以10位患有牙齒敏感症狀與牙周疾病自覺症狀 齦腫脹、出血），有口臭之自願受試者進行評價。首 令受試者停止口腔清潔1整天，對氟樹脂製採樣容器 樣袋（Tedlar bag) ，N 型，尺寸·· 1L，Sanplatec 公 Q )呼氣並採樣1 L，再由1 0位調香師根據後述基準評 因於牙周病之口臭，將其評點記爲S 1。 其次，每次使用1 g試驗用牙膏，1天2次，以 方法（使用牙刷進行刷牙3分鐘）使用1個月後，同 受試者停止口腔清潔1整天，對氟樹脂製採樣容器（ 袋（Tedlar bag) ，N 型，尺寸：1L，Sanplatec 公司 呼氣並採樣1 L，再由1 〇位調香師根據後述基準評價 於牙周病之口臭，將其評點記爲S2。 根據下式計算出各受試者之起因於牙周病之口臭 DSM 酸酯 藏野 )， 、羧 醇、 品原 醇係 (牙 先， (採 司製 價起 一般 樣令 採樣 製） 起因 之改 -19- 201034697 善度，並求出1 〇位受試者之平均値。將該平均値根_ _ 述之判定基準進行判定。 起因於牙周病之口臭之改善度= S1-S2 <評價基準> 5:起因於牙周病之口臭極強。 4 :起因於牙周病之口臭強。 3 :起因於牙周病之口臭稍強。 2:只有些微起因於牙周病之口臭。 1:幾乎沒有起因於牙周病之口臭。 〇:完全沒有起因於牙周病之口臭。 <判定基準> ◎ : 3 · 5點以上，5點以下 〇：2.5點以上，未達3 . 5點 △ : 1點以上，未達2 · 5點 X :未達1點 [實驗例2]使用感之評價 對使用各種牙膏之有象牙質牙齒敏感症症狀之10位 受試者，令其每次使用lg試驗用牙膏，以一般方法使用 3分鐘（使用牙刷進行刷牙3分鐘），根據下述基準評價 使用時之苦味等官能性的使用感，並求出1 0位的平均値 。將該平均値根據後述之基準進行判定。 -20- 201034697 <評價基準> 4 :完全未感覺到苦味，使用感極佳。 3:幾乎感覺不到苦味，使用感可。 2 :感覺到些微苦味，使用感稍不佳。 1 :感覺到強烈苦味，無法使用。 0 <判定基準> ◎ : 3 · 5點以上，4點以下 〇：3點以上，未達3.5點 △ : 2點以上，未達3點 X :未達2點 [實驗例3]牙齒敏感抑制效果之評價 對使用各種牙膏之有象牙質牙齒敏感症症狀之10位 Q 受試者，令其每次使用ig試驗用牙膏，以一般方法使用 5分鐘（使用牙刷進行刷牙5分鐘），根據下述基準評價 使用時之疼痛’並求出1 0位的平均値。將該平均値根據 後述之基準進行判定。 <評價基準> 4:完全未感覺疼痛’可進行刷牙5分鐘。 3 :感覺很小的疼痛，但可刷牙3分鐘沒有問題。 2 -感覺稍稍疼痛，可刷牙1分鐘。 -21 - 201034697 1 ··感覺強烈疼痛，無法刷牙1分鐘。 <判定基準> ◎ : 3.5點以上，4點以下 〇：3點以上，未達3 · 5點 △ : 2點以上，未達3點 X :未達2點 [實驗例4 ]齒垢去除效果之評價 對使用各種牙膏之有象牙質牙齒敏感症症狀之1〇位 受試者，令其每次使用lg試驗用牙膏，以一般方法使用 3分鐘（使用牙刷進行刷牙3分鐘）’根據非專利文件1 之方法，進行齒垢染色，及標示於染色時各受試者之4個 齒面（近心面、遠心面、唇側面、舌側面）是否附著有 被染上顏色之齒垢’再根據下式計算出PI (牙菌斑指數 )。1 0位受試者之平均p 1根據後述之基準進行判定。 PI (%) = ((附著有齒垢之齒面的合計）/(受試齒面數））xl00 <評價基準> 4 :未達2 5 % 3 : 2 5 %以上，未達4 5 °/。 2 ·· 4 5 %以上，未達7 5 % 1 : 7 5 %以上 -22- 201034697 <判定基準> ◎ ·· 3.5點以上，4點以下 〇：3點以上，未達3.5點 △ : 2點以上，未達3點 X :未達2點 Q [實驗例5 ]抑制發炎效果之評價 於倉鼠頰袋上製造因燙傷引起的發炎，再於頰袋上塗 布約〇. 1 g之檢體（牙膏組成物）。5小時後取出頰袋。測 定頰袋質量，以與無處置部位（相反側之頰袋）之質量差 可算出浮腫抑制率。對8隻倉鼠進行試驗，計算出相對於 無處置部位之平均浮腫抑制率（％ ) ’以下述基準進行判 定。 ¢) 平均浮腫抑制率（％) 二100-((無處置部位之質量-塗布檢體部位之質量）/(無處置部位之質量））X 100 <判定基準> ◎:平均浮腫抑制率爲20%以上 〇：平均浮腫抑制率爲1 0%以上，未達20% △:平均浮腫抑制率爲5 %以上，未達1 0 % X :平均浮腫抑制率未達5 % -23- 201034697 表1 組成(％) 實施例 1 實施例 2 實施例 3 實施例 4 實施例 5 實施例 6 ㈧ 成 分 抗壞血酸-2-磷酸鎂 0.3 0.05 0.1 0.24 0.5 1 抗壞血酸-2-磷酸鈉 • _ _ _ • 抗壞血酸-2-硫酸酯 _ • _ _ ㈧成分合計 0.3 0.05 0.1 0.24 0.5 1 (B) 成 分 乳酸鋁 2.2 1 2.5 2.2 2.2 2.2 硝酸鉀 5 1 2.5 5 5 5 (B)成分合計 7_2 2 5 7.2 Ί2 7.2 ((B戚分合計/ (A)成分合計） (質量比） 24.0 40.0 50.0 30.0 14.4 7.2 其 他 成 分 沉源性二氧化矽 15 15 15 15 15 15 增黏性二氧化矽 4 4 4 4 4 4 羧基甲基纖維素鈉 1.5 1.5 1.5 1.5 1.5 1.5 70%山梨醇 50 50 50 50 50 50 丙二醇 3 3 3 3 3 3 單氟隣酸鈉 0.73 0.73 0.73 0.73 0.73 0.73 氫氧化鈉 0.4 0.4 0.4 0.4 0.4 0.4 十院基硫酸納 1 1 1 1 1 1 糖精鈉 0.15 0.15 0.15 0.15 0.15 0.15 香料 1 1 1 1 1 1 水 餘量 餘量 餘量 餘量 餘量 餘量 合計 100 100 100 100 100 100 起因於牙周病之口 臭改善率之判定 ◎ 〇 〇 ◎ ◎ ◎ 使用感 ◎ ◎ 〇 ◎ ◎ ◎ 抑制牙齒敏感之判定 ◎ ◎ ◎ ◎ ◎ ◎ 去除齒垢之判定 ◎ ◎ ◎ ◎ ◎ ◎ 抑制發炎之判定 ◎ 〇 〇 ◎ ◎ ◎ -24- 201034697 表2201034697 VI. Description of the Invention: [Technical Field] The present invention relates to an excellent anti-tooth sensitivity effect, and can exert an extremely high prevention effect on a bad breath caused by periodontal disease, an inflamed effect in the oral cavity, and an effect of removing tartar. It has a good feeling of use, and can effectively inhibit or prevent tooth-sensitive symptoms and bad odor, inflammation, and the like, which are caused by the symptoms of periodontal disease. Q [Prior Art] Periodontal disease and dental caries are associated with two major diseases in the oral cavity, accounting for more than half of the causes of lost teeth. It is generally believed that periodontal disease is mostly caused by infections caused by bacteria which are mainly facultative anaerobic Gram-negative bacilli, and as a result, connective tissue and alveolar bone are destroyed. The course of the disease can be seen clinically as inflammation, swelling, bleeding, drainage, bad breath, gum atrophy and the like. The neutrophils in the body have the function of killing bacteria and defending the human body, but especially in the chronic inflammatory reaction, the cellular components released by them and the excess active oxygen produced by Q cause adverse effects on human tissues. Thus, by using an antioxidant such as ascorbic acid and its derivatives, the destruction of tissues by active oxygen can be effectively prevented. Patent Document 1 has proposed to mix ascorbate and its derivatives in a dentifrice composition, which can effectively suppress bad breath and inflammation caused by periodontal disease. Further, in the case of periodontal disease, the gums are atrophied, and the dentin of the roots of the teeth is exposed, and as a result, symptoms of tooth sensitivity sometimes occur. Ivory tooth sensitivity is defined as the appearance of dentin in the root of the tooth. Due to the external stimulation of the ivory, which is hot, cold, chemical, mechanical, etc., the production of -5 - 201034697 gives a short, very unpleasant pain. It is generally believed that the cause of the pain is that the pulp nerve is stimulated via the exposed ivory tubules. In the past, considerable research has been conducted on the prevention and treatment of dentinal tooth sensitivity. For example, Patent Documents 2 to 5 have reported potassium salts, barium salts, zinc chlorides, aluminum salts, and the like which are effective ingredients for preventing and treating dentin tooth sensitivity. In particular, Patent Document 6 and the like have reported that the potassium salt can increase the concentration of extracellular potassium ions to lower the sensory nerve activity, making the sensory nerve blunt, and alleviating the pain caused by nerve sensitivity. Further, Patent Documents 6, 7 and the like report that the ivory tubule can be narrowed or occluded by the aluminum salt, and the nerve transmitted to the pulp can be prevented from being stimulated. When there is a symptom of tooth sensitivity, it is painful when brushing teeth, and it is difficult to perform general brushing. Therefore, it becomes difficult to sufficiently remove tartar and pathogenic bacteria causing periodontal disease, and it may have an adverse effect on maintaining oral hygiene. It is easy to cause bad breath caused by periodontal disease. If the pain caused by tooth sensitivity is effectively alleviated, the brushing step can be performed more carefully. However, tooth-sensitive inhibitory substances such as aluminum lactate have a strong bitter taste and have a problem of use. Although there have been described in the patent documents 8, 9 and the like for improving the feeling of use of the mixed tooth sensitive inhibitory dentifrice, the effects are not sufficient. A dentifrice which is mixed with a tooth-sensitive inhibitor has difficulty in brushing teeth for a long time because of the feeling of use. Therefore, it is currently expected to develop an excellent preventive and therapeutic effect on teeth, and even in the state of sensitive teeth, the brushing step can be performed more carefully, the tartar is sufficiently removed, and the periodontal disease prevention effect is fully exerted, and A dentifrice composition which is also good in use. -6 - 201034697 In addition to the oral care composition containing ascorbate, Patent Document 10 proposes that potassium nitrate, etc., which is an auxiliary active ingredient, can be arbitrarily mixed because it is a component which can reduce tooth sensitivity. However, in this technique, the ratio of the ascorbate or its salt to the two components when used with aluminum lactate and/or potassium nitrate is not indicated, and there is no suggestion regarding the above problems. From this technology, it is also difficult to expect proper use of ascorbate or its salt with aluminum lactate and/or potassium nitrate to obtain a higher sensitivity to inhibit teeth, a good bad breath effect, an anti-inflammatory effect and a removal. Tartar effect. PRIOR ART DOCUMENT Patent Document Patent Document 1: JP-A-62-96408 Patent Document 2: JP-A-6 1 _3 62 1 2 Patent Document 3: US Patent No. 3 8 63 006 Specification Patent Document 4: Special Japanese Patent Laid-Open Publication No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. JP-A-2003-73 No. 282, Patent Document 9 · Special opening 2〇〇1 - 1 72 1 46 pp. Patent Document 10: Special Table 2005 - 5 03 3 22 Non-Patent Document Non-Patent Document 1: Okuda et al. [News of Oral Microbiology (2002) p. 380 201034697 [Problem to be Solved by the Invention] The present invention has been made in view of the above-mentioned state of the art to provide an excellent tooth-sensing-inhibiting effect, and even in the presence of a symptom of tooth sensitivity In addition, the brushing step can be performed carefully, and the high tartar removal effect can be performed, and the effect of improving the bad breath caused by periodontal disease and the effect of suppressing inflammation can be exerted, thereby reducing the use of bitterness from the sensitive component of tooth sensitivity. And may have In order to achieve the above object, the inventors of the present invention have focused on the composition of the dentifrice which is caused by the effects of symptoms such as bad breath and inflammation of the periodontal disease. A) at least one or more selected from the group consisting of ascorbate and a salt thereof and (B) aluminum lactate and/or potassium nitrate, and mixing the content of the component (B) / (A) in a mass ratio of 2 to 50 The two components can be multiplied to have an excellent effect of suppressing tooth sensitivity, and even for users with symptoms of tooth sensitivity, the brushing step can be carefully performed to thereby improve the tartar removal effect, and due to the active ingredient Infiltrated, it can exert an extremely high anti-inflammatory effect, and can effectively suppress the symptoms of bad breath and inflammation caused by periodontal disease, and has almost no bitter taste. The dentifrice composition of the present invention is obtained by using at least one or more selected from the group consisting of (A) ascorbic acid ester and a salt thereof, and (B) aluminum lactate and/or potassium nitrate in a specific ratio to impart a sensitivity-inhibiting component from teeth. The bitterness is improved and the -8-201034697 has a good sense of use. In addition, at the same time, it has been found that since the user has a good feeling of use, even if it is used in a state in which the tooth is sensitive, the user can take a longer time to carefully perform the brushing step to further enhance the tartar removal effect and because the ascorbic acid is made Ester or its salt is more likely to reach the target site. It is found that ascorbic acid ester and its bad breath are caused by periodontal disease, and ascorbic acid ester or its salt can obtain satisfactory effects on inhibiting inflammation and bad breath, effectively preventing or inhibiting tooth sensitivity and periodontal disease. disease. In the present invention, the component (A) and the component (B) can be used in an appropriate ratio, and the component (A) or the component (B) can be used alone by the multiplication of the two components. Or use the two components in an improper proportion to achieve the effect that can not be achieved. In particular, the component (A) is contained in an amount of 0.1 to 1% by mass. The component (B) is 2 to 8 mass%, and the content ratio of the component (B)/component (A) is 4 to 3 0, which is obtained as described above. It has an excellent effect of suppressing tooth sensitivity, suppressing the effect of inflammation in the oral cavity caused by periodontal disease and suppressing the effect of bad breath, and also has a Q dentifrice composition which has a good feeling of removing tartar. Accordingly, the present invention provides the following dentifrice composition. Item 1 : A dentifrice composition characterized by (A) at least one selected from the group consisting of ascorbate and a salt thereof, and (B) aluminum lactate and/or potassium nitrate, and (B) component / (A) The content ratio of the components is 2 to 50 by mass. Item 2: The dentifrice composition of claim 1, wherein the ascorbate is selected from the group consisting of ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-2-poly-9 - 201034697 phosphate, ascorbic acid-2 At least one or more of sulfate, ascorbic acid-2-palmitate, and ascorbyl-2- stearate ascorbyl phosphate. Item 3. The dentifrice composition of claim 1, wherein the ascorbate is ascorbyl phosphate. Item 4: The dentifrice composition of claim 1, wherein the component (A) is a sodium or magnesium salt of ascorbyl phosphate. The dentifrice composition according to any one of claims 1 to 4, wherein the component (A) is 0.05 to 2% by mass, and the component (B) is 1 to 9% by mass. The dentifrice composition according to any one of claims 1 to 4, wherein the component (A) is 0.1 to 1% by mass, and the component (B) is 2 to 8% by mass, and (B) The composition ratio of the component / (A) is a mass ratio of 4 to 3 〇〇 application 7 '. The dentifrice composition according to any one of claims 1 to 6, which is further blended with a honing agent and a viscous agent. The agent, the binder, and the surfactant are prepared into a toothpaste. The dentifrice composition according to any one of claims 1 to 7, which is for inhibiting or preventing tooth sensitivity or periodontal disease. -10-201034697 [Effect of the Invention] The dentifrice composition of the present invention has an excellent effect of suppressing tooth sensitivity, has a high tartar removal effect, can exert a bad breath improving effect, and suppress an inflammatory effect in the oral cavity, and has almost no teeth. The bitter taste of the sensitive inhibitory component has a good feeling of use. Even for users with symptoms of tooth sensitivity, the brushing step is carefully performed for a long time, and can be effectively used for the prevention of tooth sensitivity and periodontal disease for prevention and treatment. Hereinafter, the present invention will be described in detail. The dentifrice composition of the present invention contains (A) at least one selected from the group consisting of ascorbyl esters and salts thereof, and (B) aluminum lactate and/or potassium nitrate. Ascorbic acid ester can be used to form an ester of phosphoric acid, polyphosphoric acid, sulfuric acid, a fatty acid, and other pharmaceutically acceptable compounds with one or more hydroxyl groups at any of positions 2, 3, 5, and 6 of ascorbic acid. By. For example, ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid-2-palmitic acid Ester, ascorbyl-6-palmitate, ascorbyl-2- stearate, ascorbyl-6-stearate, ascorbic acid-2,6-dibutyl ester, ascorbic acid-2,6-stearate, etc. . Further, the salts thereof may, for example, be an alkali metal salt such as a sodium salt, a potassium salt, a calcium salt or a magnesium salt, or an alkaline earth metal salt. The ascorbate and the salt thereof may be contained in a single type or in a combination of two or more kinds, and the stability of the composition in the ascorbic acid ester is particularly esterified by using the hydroxyl group at the second or third position of the ascorbic acid. Ascorbic acid-11 - 201034697 Acid-2-phosphate, ascorbyl-3-phosphate, ascorbyl-2-polyphosphate, ascorbyl-2-sulfate, ascorbyl-2-palmitate, ascorbic acid-2-hard An ester ester is preferred. In the ascorbate, phosphate is dissolved in the human body and is dephosphorylated by the action of the enzyme phosphatase, which is widely present in the human body, in the form of ascorbic acid, and the bad breath caused by periodontal disease. • Inflammation has excellent suppression and is especially good. As the ascorbic acid phosphate salt, a salt which is effective for suppressing bad breath and inflammation caused by periodontal disease is preferably a magnesium salt or a sodium salt. Such ascorbic acid esters are commercially available, for example, from Showa Denko Co., Ltd. and DSM Nutritional Products Japan. The content of ascorbate and its salt is preferably from 5 to 2% (% by mass, the same as the following) of the total composition of the composition due to the inhibitory effect on the bad breath and inflammation caused by periodontal disease, especially 0.1~ 1% is better, when it is less than 0.05%, the inhibitory effect on bad breath and inflammation caused by periodontal disease is insufficient. When more than 2%, it will feel bitterness when used, and there may be a case of poor use. And potassium nitrate is used as a tooth sensitive inhibitor, and aluminum lactate or potassium nitrate may be separately mixed, or aluminum lactate and potassium nitrate may be combined. As the aluminum lactate, for example, a person from the Musashino Chemical Research Institute can be used. Potassium nitrate can be used, for example, from the sale of Otsuka Chemical Co., Ltd. (limited shares). The mixing amount of aluminum lactate and/or potassium nitrate is preferably 1 to -12 to 201034697 9% of the total composition, and is desirably 2 to 8%. When the amount of mixing is less than 1%, the effect of not fully exerting the sensitivity of the teeth and the effect of cleaning the teeth cannot be fully removed without fully removing the tartar. When the 9% is exceeded, the expected increase is not achieved. 'There will be a situation in which bitterness is produced and the use is not good. Further, the content of aluminum lactate is preferably from 1 to 5% by weight of the total composition, particularly from 1 to 3%, from the viewpoint of the effect of the tooth-sensitive inhibitor. When Q is less than 1%, it may not be able to fully exert the tooth sensitivity suppression effect, and the tooth cleaning effect cannot be achieved without fully removing the tartar. When the 5% is exceeded, the expected increase effect is not achieved. On the contrary, there will be a situation in which bitterness is generated and the use is not good. The content of potassium nitrate is preferably from 1 to 8% of the total composition, particularly from 2 to 7%, from the viewpoint of the effect of the tooth-sensitive inhibitor. When it is less than 1%, the tooth sensitivity prevention effect cannot be fully exerted, and the tooth cleaning effect cannot be performed without being able to fully remove the tartar. When it exceeds 8%, Q may be too bitter and the feeling of use may be poor. In the present invention, the content ratio of the component (A) to the component (B) ((B)/(A)) is preferably 2 to 50, more preferably 4 to 30, and the range is set to be The composition has good flavor and good use, and the bad breath* has good inflammation inhibition effect in the oral cavity, and the tooth sensitivity effect and the tartar removal effect are suppressed. Further, by the above-mentioned mixing ratio, it is possible to obtain a good feeling of good taste, to suppress the pain during brushing, and to improve the preventive effect against the bad breath and inflammation caused by periodontal disease and the sensitization of dentin, so that the user can take a long time. Carefully perform the brushing step to remove tartar more highly. Quality-13- 201034697 When the ratio is less than 2, 'sufficient tooth allergy easing effect is not obtained, and the tartar removal effect cannot be obtained because the complete brushing step cannot be performed. If it exceeds 50, sufficient bad breath cannot be obtained. The effect is that the bitterness is produced, and the effect of the present invention cannot be achieved in any case. The dentifrice composition of the present invention can be prepared into a paste, a gel, a liquid, a liquid, a solid, a chewing gum or the like, and is further prepared into a toothpaste, a liquid toothpaste, a moisturizing toothpaste, a powdered toothpaste, a liquid. Toothpaste such as toothpaste can be prepared as a toothpaste in particular, and any component other than the above-mentioned essential components can be mixed with other additives depending on the dosage form. When making toothpaste, 'can be used with honing agents, thickeners, binders, surfactants' and sweeteners, preservatives, colorants (pigments), preservation stabilizers, various active ingredients, perfumes, solvents The components are mixed and manufactured. The honing agent to be used may be a cerium dioxide-based honing agent such as a cerium dioxide, a oxidized political gel, an aluminosilicate cerium salt or a zirconium lanthanide, a cerium hydroxide, a calcium dihydrogen phosphate salt and an anhydrous salt. Salt, acid calcium pyrophosphate, sodium hexametaphosphate, hydroxyapatite, heavy and light calcium carbonate, zirconium silicate, alumina, magnesium carbonate, tri-magnesium phosphate, synthetic resin-based honing agent, etc. Oxidized sand honing agents are most suitable. The content of the honing agent is generally preferably 〇~4〇%, 2~30. /. Better. The viscosity agent may be a polyol, a sugar alcohol or the like, which may contain, for example, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, and reduced maltose. , instant lactose and so on. The viscosity of the adhesive is -14-201034697 and is generally 1~60%. Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, gums such as Sanxian gum, tragacanth, carrageenan, and gum arabic, polyvinyl alcohol, crosslinked sodium polyacrylate, and non-crosslinked type. A carboxy propylene polymer such as sodium polyacrylate, an organic binder such as carrageenan, sodium alginate or polyvinylpyrrolidone, a cerium oxide gel, an aluminum bismuth citrate gel, a glutinous rubber, or a laponite. Adhesive. The binder content is generally from 2 to 10% of the composition. 0 The surfactant may contain an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant. Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium tetradecyl sulfate, sodium N-dodecyl creatinine, and sodium N-tetradecyl creatinine. N-fluorenyl group such as sodium decyl creatinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid monoglycol monosulfate, sodium lauryl sulfonate, sodium N-hexadecyl glutamate A glutamate, sodium N-methyl-N-mercapto taurate, sodium N-methyl-N-mercaptopropionate, sodium a-olefin sulfonate, and the like. Examples of the nonionic Q surfactant include sugar alcohol fatty acid esters such as fatty acid sorbitan ester, polyoxyethylene fatty acid sorbitan ester, and sucrose fatty acid ester, ethylene glycol fatty acid ester, and polyethylene glycol fatty acid ester. Polyol fatty acid esters such as polyoxyethylene glycol fatty acid esters and polyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkylphenyl groups An ether type active agent such as ether or polyoxyethylene hydrogenated castor oil, or a fatty acid alkanolamine such as lauric acid diethanolamine. The cationic surfactant may, for example, be an alkylammonium or an alkylphenylammonium salt. The amphoteric surfactant may, for example, be betaine acetate, imidazolinium betaine or lecithin. -15- 201034697 The amount of the surfactant to be mixed is generally preferably ～1 5 % of the composition, more preferably 0.5 to 10%. Examples of spices include peppermint oil, spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, citrus oil, peppermint oil, and alfalfa oil. Oil, oyster sauce, orange peel oil, lime oil, lavender oil 'rosemary oil, laurel oil, chamomile oil, fragrant celery oil, marjoram oil, bay oil, lemongrass oil, oregano oil, dwarf pine needle Oil, neroli, rose oil, jasmine oil, fragrant roots, 'paste peppermint essential oil, rose essential oil, orange blossom and other natural flavors, and the natural flavors are processed (pre-steamed section, post-steamed portion) Perfume after the section 'saturated, liquid-liquid extraction, extraction, powder flavoring, and menthol, carvone, anethole, eucalyptol, methyl salicylic acid, cinnamaldehyde, eugenol, 3-1 -Mentyloxypropyl-1,2-diol, thyme, linalool, vinegar, vinegar, lemon olein, menthone, menthyl acetate, N-substituent Amine, terpene, awake, citric acid 'long leaf menthone, acetic acid vinegar, anisaldehyde, ethyl acetate, ethyl butyl , propenylcyclohexanol propionate, methyl aminobenzoate, methyl phenyl epoxy propionate, vanillin, undecanolactone, hexanal, propanol, butanol, isoamyl alcohol, A single perfume such as alcohol, dimethyl sulfide, cyclobutene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate or ethyl thioacetate. Further, it is known as a strawberry flavor, an apple spice, a banana spice, a pineapple spice, a grape spice, a mango spice, a butter flavor, a cow's milk flavor, a comprehensive fruit flavor, a tropical fruit flavor, etc., and can be used for the composition of the dentifrice. Spice material. Further, the content is not particularly limited, but the aforementioned fragrance material is preferably 0.000001 to 1% of the composition of the preparation in an amount of -16 to 201034697. Further, the perfume for aroma after the use of the above perfume material is preferably used in an amount of 0.1 to 2.0% of the composition of the preparation. Examples of the sweetener include sodium saccharin, stevioside, stevia extract, neohesperidin dihydrochalcone, licorice, perilla sugar, p-methoxycinnamaldehyde, aspartame, xylitol and the like. Examples of the preservative include butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, p-hydroxybenzoate such as ethyl p-hydroxybenzoate, sodium benzoate, cetylpyridinium chloride, and isopropylmethylbenzene. Potassium hexadienoate and the like. Examples of the coloring agent include blue No. 1, blue 4, and green No. 3. Examples of the storage stabilizer include vitamins such as vitamin E, sulfites such as sodium sulfite, sodium bisulfite, and sodium hydrogen sulfite, butylhydroxytoluene, propyl gallate, and butylhydroxymethoxybenzene. In addition to the components (A) and (B), the active ingredient may, for example, be a water-soluble compound such as a monofluorophosphate such as sodium monofluorophosphate or a fluorine-containing compound Q such as sodium fluoride or a potassium salt of orthophosphoric acid or a sodium salt. Phosphate compound, allantoin, allantoin aluminum chlorohydrate, cedar phenol, sodium chloride, dl-tocopherol, coenzyme Q10, dihydrocholesterol, bisabolol, chlorhexidine salt, triclosan, flat Chlorophenol, isopropylmethylbenzene, blood root extract, chamomile ring, licorice, glycyrrhetinic acid, copper chlorophyll sodium, chlorophyll, glycerol phosphate and other chelating phosphate compounds, copper compounds such as copper gluconate, chlorination Beryllium, berberine hydrochloride, hydroxyacetic acid and its derivatives, pyrophosphate, tripolyphosphate, zeolite, vinyl methyl ether, anhydrous maleic acid copolymer, polyvinylpyrrolidone, epidihydrocephalenol, Cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, -17- 201034697 sodium chloride, dihydrocholesterol, trichlorosymmetric diphenylurea, zinc citrate, glucanase, dextran Allosteric Hydrolase, Protease, Angelica Extract, Astragalus Extract, Germany An extract such as chamomile, clove, rosemary, sassafras, safflower, etc., is mixed in an effective amount within a range not inhibiting the effects of the present invention, and the content of any of the components is within a range not impeding the effects of the present invention. It can be added using a normal amount. The collection container of the dentifrice composition of the present invention may be used in addition to a hose such as an aluminum waterproof laminated hose or a glass-deposited plastic hose, and may also be used in a disposable container, a pillow bag, or the like which is made of mechanical or pressure difference. The film packaging container may be filled into a bottle or the like by means of injection, hollow, extrusion, vacuum or the like. [Embodiment] [Examples] Hereinafter, the present invention will be specifically described by way of Experimental Examples, Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, the unit of the mixing amount in the following examples is mass%. [Examples and Comparative Examples] The dentifrice composition (toothpaste) having the composition shown in Tables 1 to 4 was prepared according to the usual method and evaluated by the following experiment. The results are shown in Tables 1 to 4. The components used in the preparation of the dentifrice compositions are magnesium ascorbyl-2-phosphate (ascorbic acid p Μ, manufactured by Showa Denko Co., Ltd. -18-201034697), sodium ascorbyl-2-phosphate (SUTEI C-) 50, Nutritional Products, Inc., Japan), ascorbic acid-2-sulfur (made by ITO), aluminum lactate (made by the company), potassium nitrate (Dayu Chemical Co., Ltd.) Precipitated cerium oxide, sodium hydroxide, viscosified cerium methyl cellulose, sodium lauryl sulfate, sodium monofluorophosphate, sorbic acid, propylene glycol, sodium saccharin and water are used in combination. Old makeup 0 material (makeup base) or pharmaceutical raw material specification 2006. Yamanashi uses a 70% aqueous solution to prepare a dentifrice composition. [Experimental Example 1] Evaluation of the improvement rate of bad breath caused by periodontal disease Ten volunteers with tooth-sensitive symptoms and periodontal disease symptoms, swelling, bleeding, and bad breath were evaluated. The first order subjects stopped oral cleaning for 1 full day, and sampled the fluororesin sample container (Tedlar bag), N type, size · 1L, Sanplatec male Q) and sampled 1 L, then adjusted by 10 The scented teacher evaluated the bad breath of periodontal disease according to the criteria described later, and recorded the evaluation point as S 1 . Next, each time 1 g of test toothpaste was used, twice a day, and after 1 month of use (by brushing for 3 minutes with a toothbrush), the subject was stopped for 1 day, and the fluororesin sample container was used. Tedlar bag, N type, size: 1L, Sanplatec company exhales and samples 1 L, and then 1 调 perfumer evaluates the bad breath of periodontal disease according to the following reference, and points it as S2. The formula calculates the bad breath DSM acid esters of the periodontal disease caused by each subject, the carboxol, the proto-alcoholic system (the tooth first, the sampling system from the price of the general sample) 19- 201034697 Goodness, and find the average 値 of 1 〇 subjects. Determine the average 値 _ _ the judgment criteria. The improvement of bad breath caused by periodontal disease = S1-S2 < Benchmark > 5: The bad breath caused by periodontal disease is extremely strong. 4: The bad breath caused by periodontal disease is strong. 3: The bad breath caused by periodontal disease is slightly stronger. 2: Only slightly caused by bad breath of periodontal disease. 1: There is almost no bad breath caused by periodontal disease. 〇: There is no bad breath caused by periodontal disease. t;Judgement criterion> ◎ : 3 · 5 points or more, 5 points or less 〇: 2.5 points or more, less than 3. 5 points △: 1 point or more, less than 2 · 5 points X: less than 1 point [Experimental example 2] Evaluation of the feeling of use For each of the 10 subjects who had symptoms of ivory tooth sensitivity using various toothpastes, each time using the lg test toothpaste, the general method was used for 3 minutes (using a toothbrush for 3 minutes of brushing), The feeling of use such as bitterness at the time of use was evaluated according to the following criteria, and the average enthalpy of 10 points was determined. The average 値 was determined based on the criteria described later. -20- 201034697 <Evaluation Criteria> 4: Complete I don't feel bitterness, and I feel very good. 3: I can hardly feel bitterness and feel good. 2: I feel a little bitter taste, and I feel a little bit bad. 1 : I feel strong bitterness and can't be used. 0 <> ◎ : 3 · 5 points or more, 4 points or less 〇: 3 points or more, less than 3.5 points △: 2 points or more, less than 3 points X: less than 2 points [Experimental Example 3] Evaluation of tooth sensitivity suppression effect 10 Q subjects with symptoms of ivory tooth sensitivity using various toothpastes, each The ig test toothpaste was used for 5 minutes in a general method (tooth brushing with a toothbrush for 5 minutes), and the pain at the time of use was evaluated according to the following criteria, and the average enthalpy of 10 points was determined. The average 値 was determined according to the criteria described later. <Evaluation criteria> <4: No pain at all' can be brushed for 5 minutes. 3: Feel very small pain, but it can be brushed for 3 minutes without problems. 2 - Feeling a little pain, brushing teeth for 1 minute. -21 - 201034697 1 ··I feel strong pain and can't brush my teeth for 1 minute. <Criteria for judgment> ◎ : 3.5 points or more, 4 points or less 〇: 3 points or more, less than 3 · 5 points △ : 2 points or more, less than 3 points X : less than 2 points [Experimental Example 4 ] Tartar Evaluation of the removal effect One subject who had symptoms of ivory tooth sensitivity using various toothpastes, each time using the lg test toothpaste, using the general method for 3 minutes (using a toothbrush for 3 minutes) "According to In the method of Non-Patent Document 1, the tartar staining is performed, and the four tooth surfaces (near-heart surface, telecentric surface, lip side, and tongue side) of each subject are attached to the stained tartar 'The PI (plaque index) is calculated according to the following formula. The average p 1 of the 10 subjects was determined based on the criteria described later. PI (%) = ((total of tooth surfaces with tartar attached) / (number of teeth to be tested)) xl00 < evaluation criteria > 4 : less than 2 5 % 3 : 2 5 % or more, less than 4 5 °/. 2 ·· 4 5 % or more, less than 7 5 % 1 : 7 5 % or more -22- 201034697 <Judgement criteria> ◎ ·· 3.5 points or more, 4 points or less 〇: 3 points or more, less than 3.5 points △ : 2 points or more, less than 3 points X: less than 2 points Q [Experimental Example 5] Evaluation of inhibition of inflammation The inflammation caused by burns was produced on the hamster's cheek pouch, and then applied to the cheek pouch. About 1 g Sample (toothpaste composition). The buccal bag was taken out after 5 hours. The quality of the buccal pouch was measured to determine the edema inhibition rate from the difference in mass from the untreated portion (the opposite side of the cheek pouch). Eight hamsters were tested and the average edema inhibition rate (%) relative to the untreated site was calculated and judged on the basis of the following criteria. ¢) Mean edema inhibition rate (%) Two 100-((quality of no treatment site - mass of coated sample part) / (mass of no treatment site)) X 100 <judgment criteria> ◎: average edema inhibition rate More than 20% 〇: average edema inhibition rate of more than 10%, less than 20% △: average edema inhibition rate of 5% or more, less than 10% X: average edema inhibition rate of less than 5% -23- 201034697 Table 1 Composition (%) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 (8) Component Ascorbyl-2-phosphate Magnesium 0.3 0.05 0.1 0.24 0.5 1 Ascorbate-2-phosphate Sodium _ _ _ • Ascorbic acid -2-sulfate _ • _ _ (eight) total of 0.3 0.05 0.1 0.24 0.5 1 (B) component aluminum lactate 2.2 1 2.5 2.2 2.2 2.2 potassium nitrate 5 1 2.5 5 5 5 (B) total of 7_2 2 5 7.2 Ί 2 7.2 ( (B total amount of total / (A) total composition) (mass ratio) 24.0 40.0 50.0 30.0 14.4 7.2 Other components sinking cerium oxide 15 15 15 15 15 15 Viscosity-enhancing cerium oxide 4 4 4 4 4 4 Carboxyl group Cellulose sodium 1.5 1.5 1.5 1.5 1.5 1.5 70% sorbitol 50 50 50 50 50 50 Propylene glycol 3 3 3 3 3 3 sodium monofluorocarbonate 0.73 0.73 0.73 0.73 0.73 0.73 sodium hydroxide 0.4 0.4 0.4 0.4 0.4 0.4 ten yard sodium sulfate 1 1 1 1 1 1 sodium saccharin 0.15 0.15 0.15 0.15 0.15 0.15 fragrance 1 1 1 1 1 1 Total amount of balance margin balance total amount 100 100 100 100 100 100 Determination of bad breath improvement rate due to periodontal disease ◎ 〇〇 ◎ ◎ ◎ Sense of use ◎ ◎ ◎ ◎ ◎ ◎ ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ Determination of tartar removal ◎ ◎ ◎ ◎ ◎ ◎ Determination of inhibition of inflammation ◎ 〇〇 ◎ ◎ ◎ -24- 201034697 Table 2
組成(％) 實施例 7 實施例 8 實施例 9 實施例 10 實施例 11 實施例 12 ㈧ 成 分 抗壞血酸-2-磷酸鎂 2 0.3 0.3 0.3 抗壞血酸-2-磷酸鈉 輪 0.3 一 一 • • 抗壞血酸-2-硫酸酯 • _ 0.3 一 _ (A戚分合計 2 03 0.3 0.3 0.3 0.3 (B) 成 分 乳酸鋁 2.2 2.2 2.2 2.2 _ 1 硝酸鉀 5 5 5 - 5 1 (B)成分合計 7.2 7.2 7.2 2.2 5 2 ((B)成分合計/(A)成分合 計X質量比). 3.6 24.0 24.0 7.3 16.7 6.7 其 他 成 分 沉澱性二氧化砂 15 15 15 15 15 15 增黏性二氧化矽 4 4 4 4 4 4 羧基甲基纖維素鈉 1.5 1.5 1.5 1.5 1.5 1.5 70%山梨醇 50 50 50 50 50 50 丙二醇 3 3 3 3 3 3 單氟磷酸鈉 0.73 0.73 0.73 0.73 0.73 0.73 氫氧化鈉 0.4 0.4 0.4 0.4 0.4 0.4 十二烷基硫酸鈉 1 1 1 1 1 1 糖精鈉 0.15 0.15 0.15 0.15 0.15 0.15 香料 1 1 1 1 1 1 水 餘量 餘量 餘量 餘量 餘量 餘量 合計 100 100 100 100 100 100 起因於牙周病之口 臭改善率之判定 ◎ ◎ 〇 ◎ ◎ ◎ 使用感 〇 ◎ ◎ ◎ ◎ ◎ 抑制牙齒敏感之判定 ◎ ◎ ◎ ◎ ◎ ◎ 去除齒垢之判定 ◎ ◎ ◎ ◎ ◎ ◎ 抑制發炎之判定 ◎ ◎ 〇 ◎ ◎ ◎ -25- 201034697 表3 組成(％) 實施例 13 實施例 14 實施例 15 實施例 16 實施例 17 實施例 18 (A) 成 分 抗壞血酸-2-磷酸鎂 0.3 0.3 0.3 0.3 2 2 抗壞血酸-2-磷酸鈉 _ • • - _ 抗壞血酸-2-硫酸酯 • - _ 一 _ (A戚分合計 0.3 0.3 0.3 0.3 1 2 成 分 乳酸鋁 2.5 1 4 2.2 3 硝酸鉀 5.5 - 1 5 5 5 出戚分合計 8 1 1 9 2 8 ((B)成分合計/ ⑻成分合計） (質量比） 26.7 3.3 3.3 30.0 2.0 4.0 其 他 成 分 沉澱性二氧化矽 15 15 15 15 15 15 增黏性二氧化矽 4 4 4 4 4 4 羧基甲基纖維素鈉 1.5 1.5 1.5 1.5 1.5 1.5 70%山梨醇 50 50 50 50 50 50 丙二醇 3 3 3 3 3 3 單氟磷酸鈉 0.73 0,73 0.73 0.73 0.73 0.73 氫氧化鈉 0.4 0.4 0.4 0.4 0.4 0.4 十二烷基硫酸鈉 1 1 1 1 1 1 糖精鈉 0.15 0.15 0.15 0.15 0.15 0.15 香料 1 1 1 1 1 1 水 餘量 餘量 餘量 餘量 餘量 餘量 合計 100 100 100 100 100 100 起因於牙周病之口 臭改善率之判定 ◎ ◎ ◎ ◎ ◎ ◎ 使用感 ◎ ◎ ◎ 〇 ◎ 〇 抑制牙齒敏感之判定 ◎ 〇 〇 ◎ 〇 ◎ 去除齒垢之判定 ◎ 〇 〇 ◎ 〇 ◎ 抑制發炎之判定 ◎ ◎ ◎ ◎ ◎ ◎ -26- 201034697 表4 組成(％) 比較例 1 比較例 2 比較例 3 比較例 4 比較例 5 比較例 6 ㈧ 成 分 抗壞血酸-2福酸鎂 - - 0.3 1 1 0.05 抗壞血酸-2-磷酸鈉 - - - - 抗壞血酸-2-硫酸酯 - - - — • - L-抗壞血酸鈉 (比較品） - 0.3 - - - - (A戚分合計 0 _ 0.3 1 1 0.05 ⑻ 成 分 乳酸鋁 2.2 2.2 1 - 1 硝酸鉀 5 5 - - 1 2 (B)成分合計 7.2 7.2 0 1 1 3 (⑻成分合計/ ⑻成分合計） (質量比） - - - 1,0 1.0 60.0 其 他 成 分 沉澱性二氧化矽 15 15 15 15 15 15 增黏性二氧化矽 4 4 4 4 4 4 羧基甲基纖維素鈉 1.5 1.5 1.5 1.5 1.5 1.5 70%山梨醇 50 50 50 50 50 50 丙二醇 3 3 3 3 3 3 單氟磷酸鈉 0.73 0.73 0.73 0.73 0.73 0.73 氫氧化鈉 0.4 0.4 0.4 0.4 0.4 0.4 十二烷基硫酸鈉 1 1 1 1 1 1 糖精鈉 0.15 0.15 0.15 0.15 0.15 0.15 香料 1 1 1 1 1 1 水 餘量 餘量 餘量 餘量 餘量 餘量 合計 100 100 100 100 100 100 起因於牙周病之口 臭改善率之判定 △ △ ◎ ◎ ◎ Δ 使用感 ◎ ◎ ◎ ◎ ◎ Δ 抑制牙齒敏感之判定 ◎ ◎ X Δ Δ ◎ 去除齒垢之判定 ◎ ◎ X Δ Δ ◎ 抑制發炎之判定 Δ Δ ◎ ◎ ◎ Δ * L-抗壞血酸鈉：扶桑化學工業（股份有限）製 -27- 201034697 自表1〜4之結果可知與本發明相關之（A) 、( B ) 成分之任一個成分未加以混合時之組成，或（B )/( A )之質量比不適當之組成’對於起因於牙周病之口臭改善 效果、使用感、抑制牙齒敏感效果、去除齒垢效果、抑制 發炎效果之任一之效果均不佳，無法發揮令人滿意的效果 。相較於此，本發明之潔牙劑組成物具有優異之起因於牙 周病之口臭改善效果、抑制牙齒敏感效果、去除齒垢效果 、抑制發炎效果，且確認無苦味，具有優異的使用感。 其次，將下述之潔牙劑組成物使用與上述相同方法進 行調製，並進行相同之評價。 [實施例19]液狀牙膏 無水矽酸 1 0.0 % 三仙膠 1 • 0 糖精鈉 0 • 1 70%山梨醇溶液 35.0 甘油 20.0 丙二醇 3 0 十二烷基硫酸鈉 1 2 碳酸氫鈉 2 0 月桂酸十聚甘油醋 0 5 單氟磷酸鈉 0 73 硝酸鉀 5 0 抗壞血酸-2 -磷酸鎂 0 5 氫氧化鈉 0 4 香料 0 8 藍色1號 0 00 1 純水 殘餘量 合計 100.0 (B) / (A) =!〇.〇 -28- 201034697 評價結果如下所述。 起因於牙周病之口臭改善率 ◎ 使用感 ◎ 抑制牙齒敏感效果 ◎ 去除齒垢效果 ◎ 抑制發炎效果 ◎ Ο 另外，使用乳酸鋁取代硝酸鉀亦可得到相同結果。使 用抗壞血酸-2 -磷酸鈉取代抗壞血酸-2 -磷酸鎂亦可得到相 同結果。 〇 -29- 201034697 [實施例20]液狀牙膏 無水矽酸 1 0.0 % 三仙膠 1 .0 糖精鈉 0 • 1 70%山梨醇溶液 3 5.0 甘油 20.0 丙二醇 3 0 十二烷基硫酸鈉 1 2 碳酸氫鈉 2 0 月桂酸十聚甘油酯 0 5 單氟磷酸鈉 0 73 硝酸鉀 4 0 抗壞血酸-2-磷酸鎂 0 2 氫氧化鈉 0 4 香料 0 8 藍色1號 0 00 1 純水 殘餘量 合計 100.0% (B ) / ( A ) = 20.0 評價結果如下所述。 起因於牙周病之口臭改善率 ◎ 使用感 ◎ 抑制牙齒敏感效果 ◎ 去除齒垢效果 ◎ 抑制發炎效果 ◎ 另外，使用乳酸鋁取代硝酸鉀亦可得到相同結果。使 用抗壞血酸-2-磷酸鈉取代抗壞血酸-2-磷酸鎂亦可得到相 同結果。 -30-Composition (%) Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 (VIII) Ingredients Ascorbic acid-2-magnesium phosphate 2 0.3 0.3 0.3 Ascorbic acid sodium 2-phosphate round 0.3 One-one • Ascorbic acid-2- Sulfate • _ 0.3 a — (A total of 2 03 0.3 0.3 0.3 0.3 (B) Ingredients Aluminum lactate 2.2 2.2 2.2 2.2 _ 1 Potassium nitrate 5 5 5 - 5 1 (B) Total 7.2 7.2 7.2 2.2 5 2 ( (B) Total of ingredients / (A) total amount of X mass ratio). 3.6 24.0 24.0 7.3 16.7 6.7 Other components Precipitating silica sand 15 15 15 15 15 15 Viscosity-resistant cerium oxide 4 4 4 4 4 4 Carboxymethyl group Cellulose sodium 1.5 1.5 1.5 1.5 1.5 1.5 70% sorbitol 50 50 50 50 50 50 Propylene glycol 3 3 3 3 3 3 Sodium monofluorophosphate 0.73 0.73 0.73 0.73 0.73 0.73 Sodium hydroxide 0.4 0.4 0.4 0.4 0.4 0.4 Dodecyl sulphate Sodium 1 1 1 1 1 1 Saccharin sodium 0.15 0.15 0.15 0.15 0.15 0.15 Fragrance 1 1 1 1 1 1 Water balance balance balance balance balance balance 100 100 100 100 100 100 Bad breath caused by periodontal disease Judgment of rate ◎ ◎ 〇 ◎ ◎ ◎ Sense of use ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ -25- 201034697 Table 3 Composition (%) Example 13 Example 14 Example 15 Example 16 Example 17 Example 18 (A) Component Ascorbic acid-2-magnesium phosphate 0.3 0.3 0.3 0.3 2 2 Ascorbic acid-2-phosphate sodium _ • • - _ Ascorbic acid-2-sulfate• - _ _ (A total of 0.3 0.3 0.3 0.3 1 2 Ingredients aluminum lactate 2.5 1 4 2.2 3 Potassium nitrate 5.5 - 1 5 5 5 Out of the total of 8 1 1 9 2 8 (total of (B) components / (8) total) Mass ratio) 26.7 3.3 3.3 30.0 2.0 4.0 Other components Precipitated cerium oxide 15 15 15 15 15 15 Viscosity-resistant cerium oxide 4 4 4 4 4 4 Sodium carboxymethyl cellulose 1.5 1.5 1.5 1.5 1.5 1.5 70% sorbitol 50 50 50 50 50 50 Propylene glycol 3 3 3 3 3 3 Sodium monofluorophosphate 0.73 0,73 0.73 0.73 0.73 0.73 Sodium hydroxide 0.4 0.4 0.4 0.4 0.4 0.4 Sodium lauryl sulfate 1 1 1 1 1 1 Sodium saccharin 0.15 0.15 0.15 0.15 0.15 0.15 Spice 1 1 1 1 1 1 Water balance The balance of the remaining amount of the remaining amount of the remaining amount of 100 100 100 100 100 100 The determination of the improvement rate of the bad breath caused by periodontal disease ◎ ◎ ◎ ◎ ◎ ◎ Sense of use ◎ ◎ ◎ ◎ ◎ 〇 〇 〇 〇 〇 〇 〇 ◎ ◎ 〇〇 ◎ 〇 ◎ Determination of tartar removal ◎ 〇〇 ◎ 〇 ◎ Determination of inhibition of inflammation ◎ ◎ ◎ ◎ ◎ ◎ -26- 201034697 Table 4 Composition (%) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparison Example 6 (8) Ingredients Ascorbic Acid-2 Magnesium Fumarate - - 0.3 1 1 0.05 Ascorbate-2-Sodium Phosphate - - - - Ascorbic Acid-2-Sulphate - - - - • - L-Sodium Ascorbate (Comparative) - 0.3 - - - - (A total of 0 0.3 0.3 1 1 0.05 (8) Ingredients aluminum lactate 2.2 2.2 1 - 1 Potassium nitrate 5 5 - - 1 2 (B) Total 7.2 7.2 0 1 1 3 (Total (8) components / (8) total) (mass ratio) - - - 1,0 1.0 60.0 Other components Precipitated cerium oxide 15 15 15 15 15 15 Viscosity-resistant cerium oxide 4 4 4 4 4 4 Sodium carboxymethyl cellulose 1.5 1.5 1.5 1.5 1.5 1.5 70 % Sorbitol 50 50 50 50 50 50 Propylene glycol 3 3 3 3 3 3 sodium monofluorophosphate 0.73 0.73 0.73 0.73 0.73 0.73 sodium hydroxide 0.4 0.4 0.4 0.4 0.4 0.4 sodium lauryl sulfate 1 1 1 1 1 1 sodium saccharin 0.15 0.15 0.15 0.15 0.15 0.15 0.15 fragrance 1 1 1 1 1 1 water balance Total balance of balance margin 100 100 100 100 100 100 Determination of bad breath improvement rate due to periodontal disease △ △ ◎ ◎ ◎ Δ feeling of use ◎ ◎ ◎ ◎ Δ Δ suppression of tooth sensitivity ◎ ◎ X Δ Δ ◎ Determination of tartar removal ◎ ◎ X Δ Δ ◎ Determination of inhibition of inflammation Δ Δ ◎ ◎ ◎ Δ * L-sodium ascorbate: Fusang Chemical Industry Co., Ltd. -27- 201034697 From the results of Tables 1-4 The composition of any one of the components (A) and (B) associated with the present invention is not mixed, or the composition of the mass ratio of (B)/(A) is inappropriate for the improvement of bad breath caused by periodontal disease The effects of use, suppression of tooth sensitivity, removal of tartar effect, and suppression of inflammatory effects are all poor, and satisfactory effects cannot be achieved. In contrast, the dentifrice composition of the present invention has excellent bad breath improving effect due to periodontal disease, inhibits tooth sensitivity, removes tartar effect, suppresses inflammatory effect, and has no bitter taste, and has excellent feeling of use. . Next, the following dentifrice composition was prepared by the same method as above, and the same evaluation was carried out. [Example 19] Liquid toothpaste anhydrous citric acid 1 0.0 % Sanxianjiao 1 • 0 Saccharin sodium 0 • 1 70% sorbitol solution 35.0 Glycerol 20.0 Propylene glycol 3 0 Sodium lauryl sulfate 1 2 Sodium hydrogencarbonate 2 0 Laurel Acid decaglycerin vinegar 0 5 sodium monofluorophosphate 0 73 potassium nitrate 5 0 ascorbic acid-2 - magnesium phosphate 0 5 sodium hydroxide 0 4 fragrance 0 8 blue 1 0 0 00 1 pure water residual total 100.0 (B) / (A) =!〇.〇-28- 201034697 The evaluation results are as follows. The rate of improvement of bad breath caused by periodontal disease ◎ Sense of use ◎ Inhibition of tooth sensitivity ◎ Effect of removing tartar ◎ Anti-inflammatory effect ◎ Ο In addition, the same result can be obtained by using aluminum lactate instead of potassium nitrate. The same result was obtained by substituting ascorbic acid-2-phosphate with ascorbyl-2-phosphate. 〇-29- 201034697 [Example 20] Liquid toothpaste anhydrous citric acid 1 0.0 % Sanxianjiao 1.0 Sodium saccharin 0 • 1 70% sorbitol solution 3 5.0 Glycerol 20.0 Propylene glycol 3 0 Sodium lauryl sulfate 1 2 Sodium bicarbonate 20 decyl glycerol laurate 0 5 sodium monofluorophosphate 0 73 potassium nitrate 4 0 magnesium ascorbate-2-phosphate 0 2 sodium hydroxide 0 4 fragrance 0 8 blue 1 0 0 00 1 pure water residual Total 100.0% (B) / (A) = 20.0 The evaluation results are as follows. The rate of improvement of bad breath caused by periodontal disease ◎ Sense of use ◎ Inhibition of tooth sensitivity ◎ Effect of removing tartar ◎ Anti-inflammatory effect ◎ In addition, the same result can be obtained by using aluminum lactate instead of potassium nitrate. The same result was obtained by substituting ascorbyl-2-phosphate with sodium ascorbyl-2-phosphate. -30-