TWI445551B - Dentifrice composition - Google Patents

Description

Dentifrice composition

The invention relates to an excellent anti-tooth sensitivity effect, and can exert an extremely high prevention effect on the bad breath caused by periodontal disease, the inflammatory effect in the oral cavity and the effect of removing tartar, and the use feeling is good, and the tooth sensitivity symptom can be effectively suppressed or prevented. A dentifrice composition which is caused by symptoms of periodontal disease such as bad breath, inflammation, and the like.

Periodontal disease and dental caries are the two major diseases in the oral cavity, accounting for more than half of the causes of tooth loss. It is generally believed that periodontal disease is mostly caused by infections caused by bacteria which are mainly facultative anaerobic Gram-negative bacilli, and as a result, connective tissue and alveolar bone are destroyed. The course of the disease can be seen clinically as inflammation, swelling, bleeding, drainage, bad breath, gum atrophy and the like.

The neutrophil in the body has the function of killing bacteria and defending the human body, but especially in the case of chronic inflammatory reaction, the cellular components released by it and the excess active oxygen produced have adverse effects on human tissues. In this regard, by using an antioxidant such as ascorbic acid and its derivatives, damage to the tissue by active oxygen can be effectively prevented. Patent Document 1 has proposed to mix ascorbate and its derivatives in a dentifrice composition, which can effectively suppress bad breath and inflammation caused by periodontal disease.

Further, in the case of periodontal disease, the gums are atrophied, and the dentin of the root of the tooth is exposed, and as a result, symptoms of tooth sensitivity sometimes occur.

Ivory tooth sensitivity is defined as the appearance of dentin in the root of the tooth. Due to the external stimulation of the dentin, which is hot, cold, chemical, mechanical, etc., a very short and unpleasant pain is produced. It is generally believed that the cause of the pain is that the pulp nerve is stimulated via the exposed ivory tubules.

In the past, considerable research has been conducted on the prevention and treatment of dentin hypersensitivity. For example, Patent Documents 2 to 5 have reported potassium salts, barium salts, zinc chlorides, aluminum salts, and the like which are effective ingredients for preventing and treating dentin tooth sensitivity. In particular, Patent Document 6 and the like have reported that the potassium salt can increase the concentration of extracellular potassium ions to lower the sensory nerve activity, making the sensory nerve blunt, and alleviating the pain caused by nerve sensitivity. Further, Patent Documents 6, 7 and the like report that the ivory tubule can be narrowed or occluded by the aluminum salt, and the nerve transmitted to the pulp can be prevented from being stimulated.

When there is a symptom of tooth sensitivity, it is painful when brushing teeth, and it is difficult to perform general brushing. Therefore, it becomes difficult to sufficiently remove tartar and pathogenic bacteria causing periodontal disease, and it may have an adverse effect on maintaining oral hygiene. It is easy to cause bad breath caused by periodontal disease. If the pain caused by tooth sensitivity can be effectively alleviated, the brushing step can be performed more carefully. However, tooth-sensitive inhibitory components such as aluminum lactate have a strong bitter taste and have a problem of use. Although there have been reports on the use of the dentifrice for improving the mixed tooth sensitivity-suppressing component in Patent Documents 8, 9 and the like, the effects are not sufficient. A dentifrice which is mixed with a tooth-sensitive inhibitor has difficulty in brushing teeth for a long time because of the feeling of use.

Therefore, it is currently expected to develop an excellent preventive and therapeutic effect on teeth, and even in the state of sensitive symptoms of teeth, the brushing step can be performed more carefully, the tartar can be sufficiently removed, and the prevention of periodontal disease can be fully exerted, and A dentifrice composition which is also good in use.

Further, in the oral care composition containing ascorbate, Patent Document 10 proposes that potassium nitrate or the like as an auxiliary active ingredient can be arbitrarily mixed because it is a component which can reduce tooth sensitivity. However, in this technique, the ratio of the ascorbate or its salt to the two components when used with aluminum lactate and/or potassium nitrate is not indicated, and there is no suggestion regarding the above problems. However, it is also difficult to expect that the use of ascorbyl ester or a salt thereof and aluminum lactate and/or potassium nitrate in an appropriate manner can achieve both a higher sensitivity for suppressing teeth, an effect of improving bad breath, an anti-inflammatory effect, and removal of tartar. effect.

Prior technical document

Patent document

Patent Document 1: JP-A-62-96408

Patent Document 2: JP-A-61-36212

Patent Document 3: US Patent No. 3863006

Patent Document 4: JP-A-2006-096696

Patent Document 5: JP-A-2001-172146

Patent Document 6: JP-A-8-175943

Patent Document 7: JP-A-2003-26556

Patent Document 8: JP-A-2003-73282

Patent Document 9: JP-A-2001-172146

Patent Document 10: Special Table 2005-503322

Non-patent document

Non-Patent Document 1: Okuda et al., Latest Oral Microbiology (2002) p. 380

The present invention has been made in view of the above-mentioned state of the art, and provides an excellent tooth-sensing-inhibiting effect, and in a state in which a tooth is sensitive to a tooth, a brushing step can be performed carefully, and a high tartar removal effect can be performed, and the improvement is caused by the tooth. The effect of the bad breath of the disease and the effect of suppressing the inflammation, thereby reducing the use of bitterness from the sensitive component of the tooth, and the composition of the dentifrice which is effective in suppressing the effects of symptoms such as bad breath and inflammation of periodontal disease is purpose.

The inventors of the present invention conducted a thorough review to achieve the above object, and found that (A) at least one or more selected from the group consisting of ascorbate and a salt thereof, and (B) aluminum lactate and/or potassium nitrate, B) The content ratio of the component/(A) component is mixed in such a manner that the mass ratio is 2 to 50, and the two components can be multiplied, and the tooth sensitivity effect can be excellent, and even a patient having symptoms of tooth sensitivity can be obtained. It is also possible to carry out the brushing step carefully, thereby improving the tartar removal effect, and exhibiting an extremely high anti-inflammatory effect due to the penetration of the active ingredient, and effectively suppressing symptoms such as bad breath and inflammation caused by periodontal disease. A dentifrice composition that does not have a bitter taste.

The dentifrice composition of the present invention is obtained by using at least one or more selected from the group consisting of (A) at least one selected from the group consisting of ascorbate and a salt thereof, and (B) aluminum lactate and/or potassium nitrate in a specific ratio. The bitterness is improved and has a good sense of use. In addition, at the same time, it was found that the user can take a longer time to carefully perform the brushing step to enhance the tartar removal effect because of the good feeling of use, even in the state of having the symptoms of tooth sensitivity, and because of the ascorbic acid Ester or its salt is more likely to reach the target site. It is found that ascorbic acid ester and its bad breath are caused by periodontal disease, and ascorbic acid ester or its salt can obtain satisfactory effects on inhibiting inflammation and bad breath, effectively preventing or inhibiting tooth sensitivity and periodontal disease. disease.

In the present invention, the component (A) and the component (B) can be used in an appropriate ratio, and by the multiplication of the two components, the component (A) or the component (B) can be used alone, or The effect that cannot be achieved by using the two ingredients in an improper ratio. In particular, the content of the component (A) is 0.1 to 1% by mass, the component (B) is 2 to 8% by mass, and the content ratio of the component (B) to the component (A) is 4 to 30, which is more than the above. It has high effect, excellent tooth-sensing effect, inhibits the inflamed effect in the oral cavity caused by periodontal disease, and suppresses the effect of bad breath. It also has a dentifrice composition with good tartar removal effect.

Accordingly, the present invention provides the following dentifrice composition.

Application 1:

A dentifrice composition characterized by containing (A) at least one selected from the group consisting of ascorbic acid esters and salts thereof, and (B) aluminum lactate and/or potassium nitrate, and (B) component/(A) component content ratio The mass ratio is 2 to 50.

Application 2:

The dentifrice composition of claim 1, wherein the ascorbate is selected from the group consisting of ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid-2- At least one or more of palmitate and ascorbyl-2-stearate ascorbyl phosphate.

Application 3:

The dentifrice composition of claim 1, wherein the ascorbate is ascorbyl phosphate.

Application 4:

The dentifrice composition of claim 1, wherein the component (A) is a sodium or magnesium salt of ascorbyl phosphate.

Application 5:

The dentifrice composition according to any one of claims 1 to 4, wherein the component (A) is 0.05 to 2% by mass, and the component (B) is 1 to 9% by mass.

Application 6:

The dentifrice composition according to any one of claims 1 to 4, wherein the component (A) is 0.1 to 1% by mass, and the component (B) is 2 to 8% by mass, and the component (B) is / A) The content ratio of the components is 4 to 30 by mass.

Application 7:

The dentifrice composition according to any one of claims 1 to 6, which is further formulated with a polishing agent, a thickener, a binder, and a surfactant to prepare a toothpaste.

Application 8:

The dentifrice composition according to any one of claims 1 to 7, which is for inhibiting or preventing tooth sensitivity or periodontal disease.

The dentifrice composition of the present invention has excellent anti-tooth sensitivity effect and high tartar removal effect, can exert a bad breath improving effect and suppress an oral inflammatory effect, and has almost no bitter taste from a tooth sensitive inhibitory component. The feeling of use, even for users with symptoms of tooth sensitivity, is also carefully performed for a long time, which can be effectively used for the prevention and treatment of tooth sensitivity and periodontal disease.

Hereinafter, the present invention will be described in detail. The dentifrice composition of the present invention contains (A) at least one selected from the group consisting of ascorbyl esters and salts thereof, and (B) aluminum lactate and/or potassium nitrate.

Ascorbic acid ester can be used to form an ester of phosphoric acid, polyphosphoric acid, sulfuric acid, a fatty acid, and other pharmaceutically acceptable compounds with one or more hydroxyl groups at any of positions 2, 3, 5, and 6 of ascorbic acid. By. For example, ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid-2-palmitate, ascorbic acid- 6-palmitate, ascorbyl-2-stearate, ascorbyl-6-stearate, ascorbic acid-2,6-dibutyl ester, ascorbic acid-2,6-stearate, and the like. Further, examples of the salt include an alkali metal salt such as a sodium salt, a potassium salt, a calcium salt or a magnesium salt, and an alkaline earth metal salt.

The ascorbate and the salt thereof may be contained in a single type or in a combination of two or more types, and the stability of the composition in the ascorbic acid ester is particularly esterified by using the hydroxyl group at the second or third position of the ascorbic acid. Ascorbic acid-2-phosphate, ascorbyl-3-phosphate, ascorbic acid-2-polyphosphate, ascorbyl-2-sulfate, ascorbyl-2-palmitate, ascorbyl-2-stearate is preferred.

In the ascorbate, the phosphate ester is absorbed by the enzyme in the human body and is dephosphorylated by the action of the enzyme phosphatase, which is widely used in the human body, acts in the form of ascorbic acid, and causes bad breath caused by periodontal disease. ‧ Inflammation has excellent suppression and is especially good. Among the ascorbyl phosphate salts, a salt having a suppressing effect on bad breath caused by periodontal disease and having an inhibitory effect is preferably a magnesium salt or a sodium salt.

Such ascorbic acid esters are commercially available, for example, from Showa Denko Co., Ltd. and DSM Nutritional Products Japan.

The content of the ascorbic acid ester and the salt thereof is preferably 0.05 to 2% (% by mass, the same or less) of the entire composition, and is particularly preferably 0.1 to 1%, in terms of the inhibitory effect on the bad breath and inflammation caused by periodontal disease. Preferably, when the amount is less than 0.05%, the effect of suppressing bad breath caused by periodontal disease is insufficient, and when it exceeds 2%, bitterness is felt when used, and a feeling of use may be unsatisfactory.

Aluminum lactate and potassium nitrate can be used as tooth-sensitive inhibitors, and aluminum lactate or potassium nitrate can be separately mixed, or aluminum lactate and potassium nitrate can be combined.

Aluminum lactate can be used, for example, from the manufacturer of the Musashino Chemical Research Institute.

Potassium nitrate can be used, for example, from the company of Otsuka Chemical Co., Ltd. (limited shares).

The total amount of the aluminum lactate and/or potassium nitrate is preferably from 1 to 9% by weight in total, and is preferably from 2 to 8%. When the amount of mixing is less than 1%, the effect of suppressing the sensitivity of the teeth may not be fully exerted, and the effect of cleaning the teeth may not be performed, and the tartar may not be sufficiently removed. When the amount exceeds 9%, the expected increase effect is not achieved. On the contrary, there will be cases of bitterness and poor use.

Further, the content of aluminum lactate is preferably from 1 to 5% of the total composition, particularly from 1 to 3%, from the viewpoint of the effect of the tooth-sensitive inhibitor. When it is less than 1%, it will not be able to fully exert the sensitivity of tooth sensitivity, and it will not be able to exert the effect of cleaning the teeth without fully removing the tartar. When it exceeds 5%, it will not only fail to achieve the expected increase effect, but instead There will be cases of bitterness and poor use.

The content of potassium nitrate is preferably from 1 to 8% of the total composition, particularly from 2 to 7%, from the viewpoint of the effect of the tooth-sensitive inhibitor. When it is less than 1%, the effect of suppressing the sensitivity of the teeth may not be fully exerted, and the effect of cleaning the teeth may not be performed, and the tartar may not be sufficiently removed. When the 8% is exceeded, the bitterness is too strong and the feeling of use is not good.

In the present invention, the content ratio of the component (A) to the component (B) ((B)/(A)) is preferably from 2 to 50, more preferably from 4 to 30, and the range is set here. The composition has good flavor and good use, and the bad breath ‧ the oral inflammation inhibition effect is good, the tooth sensitivity effect and the tartar removal effect are suppressed. Further, by the above-mentioned mixing ratio, it is possible to obtain a good feeling of good taste, to suppress the pain during brushing, and to improve the prevention effect against the bad breath caused by periodontal disease, the prevention effect of inflammation, and the sensitivity of dentin sensitivity, so that the user can take a long time. Carefully perform the brushing step to remove tartar more highly. quality When the amount ratio is less than 2, sufficient tooth allergy relief effect cannot be obtained, and since the complete brushing step cannot be performed, the tartar removal effect cannot be obtained, and when it exceeds 50, sufficient bad breath ‧ inflammation inhibition effect is obtained, and bitterness is generated. The feeling of use is not good, and the effect of the present invention cannot be achieved anyway.

The dentifrice composition of the present invention can be prepared into a paste, a gel, a liquid, a liquid, a solid, a chewing gum or the like, and is further prepared into a toothpaste, a liquid toothpaste, a moisturizing toothpaste, a powdered toothpaste, and a liquid. Toothpaste such as toothpaste can be prepared as a toothpaste in particular, and any component other than the above-mentioned essential components can be mixed with other additives depending on the dosage form.

When it is made into toothpaste, it can be used with abrasives, thickeners, adhesives, surfactants, and sweeteners, preservatives, colorants (pigments), storage stabilizers, various active ingredients, perfumes, solvents, etc. The ingredients are mixed and manufactured.

Examples of the abrasive to be used include a precipitated cerium oxide, a cerium oxide gel, an aluminum ceric acid cerium salt, a zirconium lanthanide cerium oxide abrasive, aluminum hydroxide, a dihydrogen phosphate salt, an anhydrous salt, and an acidity. Calcium pyrophosphate, hydroxyapatite, heavy and light calcium carbonate, zirconium silicate, alumina, magnesium carbonate, triammonium phosphate, synthetic resin-based abrasives, etc., but most suitable for use as a cerium oxide-based abrasive. The content of the abrasive is generally from 0 to 40%, more preferably from 2 to 30%.

The viscosity agent may be a polyol, a sugar alcohol or the like, and may, for example, contain sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, reduced maltose, reduction Lactose and so on. The content of the thickener is generally from 1 to 60%.

Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, gums such as Sanxian gum, tragacanth, carrageenan, and gum arabic, polyvinyl alcohol, crosslinked sodium polyacrylate, and non-crosslinked type. A carboxy propylene polymer such as sodium polyacrylate, an organic binder such as carrageenan, sodium alginate or polyvinylpyrrolidone, a cerium oxide gel, an aluminum bismuth citrate gel, a glutinous rubber, or a laponite. Adhesive. The binder content is generally from 2 to 10% of the composition.

The surfactant may contain an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant. Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium tetradecyl sulfate, sodium N-dodecyl creatinine, and sodium N-tetradecyl creatinine. N-fluorenyl group such as sodium decyl creatinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid monoglycol monosulfate, sodium lauryl sulfonate, sodium N-hexadecyl glutamate A glutamate, sodium N-methyl-N-mercapto taurate, sodium N-methyl-N-mercaptopropionate, sodium α-olefin sulfonate, and the like. Examples of the nonionic surfactant include sugar alcohol fatty acid esters such as fatty acid sorbitan ester, polyoxyethylene fatty acid sorbitan ester, and sucrose fatty acid ester, ethylene glycol fatty acid ester, and polyethylene glycol fatty acid ester. Polyol fatty acid esters such as polyoxyethylene glycol fatty acid esters and polyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkylphenyl ethers An ether type active agent such as polyoxyethylene hydrogenated castor oil or a fatty acid alkanolamine such as lauric acid diethanolamine. The cationic surfactant may, for example, be an alkylammonium or an alkylphenylammonium salt. Examples of the amphoteric surfactant include betaine acetate, imidazolinium betaine, and lecithin.

The amount of the surfactant to be mixed is preferably from 0 to 15% of the composition, more preferably from 0.5 to 10%.

Examples of spices include peppermint oil, spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, citrus oil, peppermint oil, and cardamom oil. , oyster sauce, orange peel oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, fragrant celery oil, marjoram oil, bay oil, lemongrass oil, oregano oil, dwarf pine oil , neroli oil, rose oil, jasmine oil, fragrant root iris, peppermint essential oil, rose essential oil, neroli and other natural flavors, and the processing of these natural flavors (pre-distillation section, post-distillation section, fractionation , liquid-liquid extraction, extraction, powder flavoring) after the spices, and menthol, carvone, anethole, eucalyptol, methyl salicylic acid, cinnamaldehyde, eugenol, 3-1-menthyloxy Propyl-1,2-diol, thymol, linalool, propylene acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, terpene, Octanal, citric acid, long leaf menthone, acetate, anisaldehyde, ethyl acetate, ethyl butyl ester, propylene Cyclohexanol propionate, methyl aminobenzoate, methyl phenyl ethyl epoxide, vanillin, undecanolactone, hexanal, propanol, butanol, isoamyl alcohol, hexanol, two A single fragrance such as methyl sulfide, cyclobutene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate or ethyl thioacetate. Further, it is known as a strawberry flavor, an apple spice, a banana spice, a pineapple spice, a grape spice, a mango spice, a butter flavor, a cow's milk flavor, a comprehensive fruit flavor, a tropical fruit flavor, etc., and can be used for the composition of the dentifrice. Spice material.

Further, the content is not particularly limited, but the above-mentioned flavoring material is preferably used in an amount of 0.000001 to 1% of the composition of the preparation. Further, the perfume for aroma after the use of the above-mentioned perfume material is preferably used in an amount of 0.1 to 2.0% of the composition of the preparation.

Examples of the sweetener include sodium saccharin, stevioside, stevia extract, neohesperidin dihydrochalcone, licorice, perilla sugar, p-methoxycinnamaldehyde, aspartame, xylitol and the like.

Examples of the preservative include butyl p-hydroxybenzoate, propyl paraben, ethyl p-hydroxybenzoate, p-oxybenzoate, sodium benzoate, cetylpyridinium chloride, isopropylmethylbenzene, and hexadienoic acid. Potassium and so on.

Examples of the coloring agent include blue No. 1, blue 4, and green No. 3.

Examples of the storage stabilizer include vitamins such as vitamin E, sulfites such as sodium sulfite, sodium bisulfite, and sodium hydrogen sulfite, butylhydroxytoluene, and propyl gallate.

Examples of the active ingredient other than the components (A) and (B) include, for example, a monofluorophosphate such as sodium monofluorophosphate, a fluorine-containing compound such as sodium fluoride, a potassium salt of orthophosphoric acid, or a sodium salt. Compound, allantoin, allantoin aluminum chlorohydrate, cedar phenol, sodium chloride, dl-tocopherol, coenzyme Q10, dihydrocholesterol, alpha-galorphanol, chlorhexidine salt, triclosan, Isopropylmethylbenzene, blood root extract, chamomile ring, licorice, glycyrrhetinic acid, copper chlorophyll sodium, chlorophyll, glycerol phosphate and other chelated phosphate compounds, copper compounds such as copper gluconate, barium chloride, hydrochloric acid Berberine, hydroxyacetic acid and its derivatives, pyrophosphate, tripolyphosphate, zeolite, polyvinylpyrrolidone, epidihydroretinol, cetylpyridinium chloride, benzethonium chloride, chlorinated phthalate Hydroxammonium, trichlorosymmetric diphenylurea, zinc citrate, glucanase, dextran allosteric hydrolase, protease, white peony extract, astragalus extract, German chamomile, clove, rosemary, scutellaria, safflower The extract or the like is mixed in an effective amount within a range not inhibiting the effects of the present invention.

Further, the content of any of the components may be added in a normal amount without departing from the effects of the present invention.

The collection container of the dentifrice composition of the present invention may be used in addition to a hose such as an aluminum waterproof laminated hose or a glass-deposited plastic hose, and may also be used in a disposable container, a pillow bag, or the like which is made of mechanical or pressure difference. The film packaging container may be filled in a bottle or the like by molding such as injection, hollow, extrusion, or vacuum.

[Examples]

Hereinafter, the present invention will be specifically described by way of Experimental Examples, Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, the unit of the mixing amount in the following examples is mass%.

[Examples, Comparative Examples]

The dentifrice composition (toothpaste) having the composition shown in Tables 1 to 4 was prepared according to the usual method and evaluated by the following experiment. The results are shown in Tables 1 to 4.

Each of the components used in the preparation of the dentifrice composition is ascorbyl-2-phosphate magnesium (ascorbic acid PM, manufactured by Showa Denko Co., Ltd.), sodium ascorbyl-2-phosphate (SUTEI C-50, DSM Nutritional Products) Made by the Japanese company), ascorbic acid-2-sulfate (made by ITO), aluminum lactate (made by the Musashino Chemical Research Institute), potassium nitrate (Otsuka Chemical Co., Ltd.), others such as precipitation Strontium dioxide, sodium hydroxide, viscous cerium oxide, carboxymethyl cellulose, sodium lauryl sulfate, sodium monofluorophosphate, sorbitol, anhydrous citric acid, propylene glycol, sodium saccharin and water It is based on the old cosmetics raw material standard (makeup base) or the raw material raw material specification 2006. The sorbitol was prepared by using a 70% aqueous solution to prepare a dentifrice composition.

[Experimental Example 1] Evaluation of improvement rate of bad breath caused by periodontal disease

Ten volunteers with symptoms of tooth sensitivity and periodontal disease (swelling gums, bleeding) and bad breath were evaluated. First, the subject was stopped from cleaning for 1 day, and the fluororesin sampling container (Tedlar bag, N type, size: 1 L, manufactured by Sanplatec) was exhaled and sampled 1 L, and then scented by 10 bits. The teacher evaluated the bad breath caused by periodontal disease according to the criteria described later, and recorded the evaluation point as S1.

Next, each time 1 g of test toothpaste was used, twice a day, after 1 month of use in a general method (brushing for 3 minutes with a toothbrush), the subject was also stopped for oral cleaning for 1 full day, and a fluororesin sampling container was used. (Tedlar bag, N type, size: 1L, manufactured by Sanplatec) exhaled and sampled 1L, and 10 perfumers evaluated the bad breath caused by periodontal disease according to the criteria described later, and recorded the evaluation point as S2. .

The degree of improvement in bad breath caused by periodontal disease in each subject was calculated according to the following formula, and the average value of 10 subjects was determined. This average value is determined based on the criterion described later.

Improvement in bad breath caused by periodontal disease = S1-S2

<Evaluation criteria>

5: The bad breath caused by periodontal disease is extremely strong.

4: The bad breath caused by periodontal disease is strong.

3: The bad breath caused by periodontal disease is slightly stronger.

2: Only slightly caused by bad breath of periodontal disease.

1: There is almost no bad breath caused by periodontal disease.

0: There is no bad breath caused by periodontal disease.

<Judgement criteria>

◎: 3.5 points or more, 5 points or less

○: Above 2.5 points, not up to 3.5 points

△: 1 point or more, less than 2.5 points

×: Less than 1 point

[Experimental Example 2] Evaluation of use feeling

Ten subjects who had symptoms of ivory tooth sensitivity using various toothpastes were given 1 g of test toothpaste each time, and used for 3 minutes in a normal manner (toothbrushing with a toothbrush for 3 minutes), and evaluated according to the following criteria. The functional feeling of use such as bitterness at the time was obtained, and the average value of 10 bits was obtained. The average value is determined based on the basis described later.

<Evaluation criteria>

4: No bitterness is felt at all, and the feeling of use is excellent.

3: I can hardly feel bitterness and feel good.

2: I feel a little bitter taste, and the feeling of use is slightly poor.

1: I feel strong bitterness and cannot be used.

<Judgement criteria>

◎: 3.5 points or more, 4 points or less

○: 3 or more points, less than 3.5 points

△: 2 or more points, less than 3 points

×: Less than 2 points

[Experimental Example 3] Evaluation of tooth sensitivity inhibition effect

Ten subjects who had symptoms of ivory tooth sensitivity using various toothpastes were given 1 g of test toothpaste each time, and used for 5 minutes in a normal manner (tooth brushing with a toothbrush for 5 minutes), and evaluated according to the following criteria. Pain at the time and find the average of 10 digits. The average value is determined based on the basis described later.

<Evaluation criteria>

4: No pain at all, brushing for 5 minutes.

3: I feel very little pain, but I can brush my teeth for 3 minutes without problems.

2: Feeling a little pain, brush your teeth for 1 minute.

1: I feel strong pain and can't brush my teeth for 1 minute.

<Judgement criteria>

◎: 3.5 points or more, 4 points or less

○: 3 or more points, less than 3.5 points

△: 2 or more points, less than 3 points

×: Less than 2 points

[Experimental Example 4] Evaluation of tartar removal effect

For each of the 10 subjects who had symptoms of ivory tooth sensitivity using various toothpastes, they used 1 g of test toothpaste each time, and used for 3 minutes in a normal manner (brushing with a toothbrush for 3 minutes), according to Non-Patent Document 1 The method comprises the following steps: performing tartar staining, and marking whether the four tooth surfaces (near heart surface, telecentric surface, lip side, tongue side) of each subject adhere to the tartar dyed with color, and then according to the following formula PI (plaque index) was calculated. The average PI of 10 subjects was determined based on the basis described later.

PI (%) = ((total of tooth surfaces with tartar attached) / (number of teeth to be tested)) × 100

<Evaluation criteria>

4: less than 25%

3:25% or more, less than 45%

2:45% or more, less than 75%

1:75% or more

<Judgement criteria>

◎: 3.5 points or more, 4 points or less

○: 3 or more points, less than 3.5 points

△: 2 or more points, less than 3 points

×: Less than 2 points

[Experimental Example 5] Evaluation of inhibition of inflammatory effect

Inflammation caused by burns was made on the hamster's cheek pouch, and about 0.1 g of the specimen (toner composition) was applied to the cheek pouch. The buccal bag was taken out after 5 hours. The quality of the buccal pouch was measured, and the edema inhibition rate was calculated by the difference in mass from the untreated portion (the opposite side of the cheek pouch). Eight hamsters were tested, and the average edema inhibition rate (%) with respect to the untreated site was calculated, and the judgment was made based on the following criteria.

Mean edema inhibition rate (%) = 100 - ((quality of no treatment site - mass of coated sample part) / (quality of no treatment site)) × 100

<Judgement criteria>

◎: The average edema inhibition rate is 20% or more

○: The average edema inhibition rate is 10% or more, less than 20%.

△: The average edema inhibition rate is 5% or more, less than 10%.

×: The average edema inhibition rate is less than 5%

From the results of Tables 1 to 4, it is understood that the composition of any of the components (A) and (B) associated with the present invention is not mixed, or the composition of (B)/(A) is inappropriate, for the cause The effect of improving the bad breath, the feeling of use, the sensitivity of the teeth, the effect of removing the tartar, and the effect of suppressing inflammation in periodontal disease are not good, and satisfactory effects cannot be obtained. In contrast, the dentifrice composition of the present invention has excellent bad breath improving effect due to periodontal disease, inhibits tooth sensitivity, removes tartar effect, suppresses inflammatory effect, and has no bitter taste, and has excellent feeling of use. .

Next, the following dentifrice composition was prepared in the same manner as described above, and the same evaluation was carried out.

[Example 19] Liquid toothpaste

(B)/(A)=10.0

The evaluation results are as follows.

Bad breath improvement rate due to periodontal disease ◎

Use feeling ◎

Suppress tooth sensitivity ◎

Remove tartar effect ◎

Inhibition of inflammation ◎

In addition, the same result was obtained by using aluminum lactate instead of potassium nitrate. The same result was obtained by substituting ascorbyl-2-phosphate with sodium ascorbyl-2-phosphate.

[Example 20] Liquid toothpaste

(B)/(A)=20.0

The evaluation results are as follows.

Bad breath improvement rate due to periodontal disease ◎

Use feeling ◎

Suppress tooth sensitivity ◎

Remove tartar effect ◎

Inhibition of inflammation ◎

In addition, the same result was obtained by using aluminum lactate instead of potassium nitrate. The same result was obtained by substituting ascorbyl-2-phosphate with sodium ascorbyl-2-phosphate.

Claims (7)

A dentifrice composition characterized in that (A) at least one selected from the group consisting of ascorbic acid esters and salts thereof is 0.05 to 2% by mass, and (B) aluminum lactate and/or potassium nitrate is 2 to 8 mass%, and (B) The content ratio of the component/(A) component is 4 to 30. The dentifrice composition of claim 1, wherein the ascorbate is selected from the group consisting of ascorbic acid-2-phosphate, ascorbyl-3-phosphate, ascorbic acid-2-polyphosphate, ascorbic acid-2-sulfate, ascorbic acid At least one of -2-palmitate and ascorbic acid-2-stearate. The dentifrice composition of claim 1, wherein the ascorbate is ascorbyl phosphate. The dentifrice composition of claim 1, wherein the component (A) is a sodium or magnesium salt of ascorbyl phosphate. The dentifrice composition according to any one of claims 1 to 4, wherein the component (A) is contained in an amount of 0.1 to 1% by mass. The dentifrice composition according to any one of claims 1 to 4, which is further formulated with a polishing agent, a thickener, a binder, and a surfactant to prepare a toothpaste. A dentifrice composition according to any one of claims 1 to 4, which is intended to inhibit or prevent tooth sensitivity or periodontal disease.