JPH0635374B2 - Oral composition - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to a composition for oral cavity, and more specifically, it is preferable for treatment of oral diseases, particularly alveolar pyorrhea, due to the astringent action of aluminum lactate on gingival tissue and oral mucosa. It relates to a composition for oral cavity containing aluminum lactate which exerts an effect.

2. Description of the Related Art In general, two major diseases in the dental field are caries and periodontal disease. Of these, periodontal disease shows a high incidence rate comparable to dental caries, as is clear from the reports on its morbidity and tooth loss status, as well as the reports on the actual condition of dental diseases in Japan. The impact on Such periodontal disease is caused by a combination of several factors, and its occurrence is related to individual differences in resistance to the disease and is expressed by extremely complicated factors. However, the most important of these various factors is considered to be the local factor, cleanliness in the oral cavity.

That is, the mechanism of the periodontal disease is that the gingival papilla and marginal area of the gingiva are swollen to cause swelling, the gingival surface is swollen, soft and easily bleeds, and further gingival inflammation occurs. It is common for the disease to expand and eventually follow the path leading to alveolar pyorrhea. Therefore, in order to prevent periodontal disease, it is important to prevent the development of simple papilla and marginal gingivitis, which are the initial symptoms, and therefore, in daily life, it is necessary to properly clean the mouth. It is important to do it. For this purpose, it is effective and rational to clean the ostium with an oral composition that is effective in preventing periodontal disease, and various agents suitable for such use have been blended. Oral compositions have been proposed.

Among the agents contained in these oral compositions, aluminum compounds such as aluminum lactate or aluminum allantoinate are useful for the prevention and treatment of oral diseases, particularly tightening of the gingiva, or periodontal diseases such as alveolar pyorrhea. It is widely recognized that it is effective, and toothpaste containing aluminum lactate is already known for the purpose of preventing and treating periodontal disease.

However, the astringent effect of aluminum lactate on the gingiva is not sufficient, and in order to obtain astringency equivalent to that of aluminum allantoinate using aluminum lactate,
About 10 times the amount of compounding is required.

SUMMARY OF THE INVENTION The present inventors have conducted extensive studies to enhance the astringency of aluminum lactate in the oral composition to the gingiva, and as a result, ascorbic acid or its sodium salt was added to the oral composition containing aluminum lactate. Surprisingly, it was found that the astringency of aluminum lactate is remarkably enhanced by the addition of Al.

That is, the present invention provides an oral composition containing aluminum lactate, characterized by containing ascorbic acid or a sodium salt thereof.

Therefore, according to the present invention, an excellent oral composition in which the astringency of aluminum lactate in the gingiva is enhanced can be obtained, and the use of the composition exhibits a preferable effect in the treatment of oral diseases, especially alveolar pyorrhea.

Other substances that enhance the astringency of aluminum lactate include sodium lauryl sulphate and benzalkonium chloride, but each of them has an astringent action, and the effect of combination with aluminum lactate is merely an additive effect. There is nothing. On the contrary, ascorbic acid or its sodium salt does not have any astringent action on its own, and therefore the combination of these and aluminum lactate produces a completely new astringent activity enhancing effect.

Detailed Description of the Invention Next, ascorbic acid or its sodium salt to be blended in the composition of the present invention, and additives other than these, the results of testing the effect of these additives to enhance the gingival astringent activity of aluminum lactate are shown. The results are shown in Table 1.

The astringent activity of each additive is described by Okuda et al. (Pharmaceutical Journal 96 , 1143 (197
6); According to the method of 97 , 1267 (1977), it was measured as follows using the adsorption action on hemoglobin.

Preparation of hemoglobin solution: Water was added to fresh human blood to which sodium citrate was added to obtain hemolyzed blood, which was prepared so that the absorbance at 578 nm was 0.95 to 1.05.

Measurement of hemoglobin adsorption effect: Hemoglobin solution 2 ml, aluminum lactate aqueous solution 1 ml,
Sample solution 1 ml (ascorbic acid, etc.), 0.2M phosphate buffer
(pH 6.0) 1 ml was mixed and stirred, left for 1 hour, then 12,000 rpm 1
After centrifuging for 0 minutes, the absorbance of the supernatant was measured at 578 nm.
The difference between the absorbance and the same absorbance without addition of hemoglobin is defined as ΔODs. The ratio of ΔODs to the absorbance (ODc) when aluminum lactate and the sample were not added was defined as the amount of supernatant hemoglobin (Hs) when the sample was added.

In the same manner as above, except that the sample was replaced with purified water, the amount of supernatant hemoglobin H when aluminum lactate alone was used.
L (HL = ΔODL / ODc × 100) was obtained.

Calculation of astringent activity: The astringent activity was increased by the amount of hemoglobin adsorbed on aluminum lactate (100-HL) as 100%, and the adsorbed amount of hemoglobin (100-Hs) of each sample was expressed as%.

As is clear from Table 1, ascorbic acid or its sodium salt, sodium lauryl sulphate, benzalkonium chloride, etc. are among those showing 100% or more enhancement, of which sodium lauryl sulphate and benzalkonium chloride are , Alone exceeds 100%, and only shows an additive effect. Contrary to this, ascorbic acid or its sodium salt alone has almost no astringent action, but in combination with aluminum lactate, an astringent activity enhancing effect is exhibited.

Thus, ascorbic acid or its sodium salt is used in the oral composition of the present invention. Further, these may be mixed and blended.

In the case of a toothpaste composition, the content of aluminum lactate in the oral composition of the present invention is 0.1 to 2 with respect to the entire composition.
It is preferably wt%. If the content of aluminum lactate is less than 0.1% by weight, a sufficient astringent effect cannot be exhibited,
On the other hand, if it exceeds 2% by weight, the taste at the time of use deteriorates, and the feeling of use becomes unbearable, which is not preferable.

The content of ascorbic acid or its sodium salt is preferably 3 to 50% by weight with respect to the content of aluminum lactate. If the blending amount is less than 3% by weight, the astringent effect is not sufficient, while if it exceeds 50% by weight, there is a problem in stability of properties such as viscosity, which is not preferable.

The oral composition of the present invention can use any of the other known components usually used in oral compositions, depending on the type thereof. For example, in the case of toothpaste, glycerin, sorbitol, etc. are used as a wetting agent.
The blending amount varies variously according to the shape of the product and is not particularly limited. Further, abrasives, binders, foaming agents, flavors, sweeteners and the like which are usually used for dentifrice may be added in a usual use ratio.

Therefore, the oral composition of the present invention may be a toothpaste or a powdered toothpaste containing no water, and may also be a product such as a mouthwash, chewing gum, tablets, and troches. In these cases, the product base material may be used with an ordinary effective base, and these are used in accordance with a conventional method.
Treat to obtain the oral composition.

Examples Next, the present invention will be described in more detail with reference to Examples. In addition, "%" means "% by weight".

Example 1 A toothpaste containing aluminum lactate and ascorbic acid was prepared according to a conventional method according to the following formulation.

Ingredient content (%) Calcium carbonate 35.0 Sorbitol 30.0 Glycerin 8.0 Carrageenan 2.0 Saccharin sodium 0.1 Perfume 1.0 Aluminum lactate 1.0 Ascorbic acid 0.4 Sodium lauryl sulphate 1.2 Water adjusted to 100% On the other hand, as a control, instead of ascorbic acid and aluminum lactate Prepare a toothpaste containing the same amount of water.

The astringent activity of the obtained toothpaste was measured in the same manner as the test agent, and the increasing strength (%) of ascorbic acid was determined.
A large enhancement effect of 5% was recognized.

Comparative Example 1 A toothpaste was prepared in the same manner as in Example 1 except that the same amount of water was used instead of ascorbic acid. Example 1
It was 134% when measured in the same manner as.

Example 2 A toothpaste was manufactured according to a conventional method according to the following formulation.

Ingredient content (%) Dibasic calcium phosphate 45.0 Sorbitol 25.0 Carrageenan 1.0 N-lauroylsarcosine sodium 0.5 Saccharin sodium 0.1 Aluminum lactate 2.0 Ascorbic acid 1.0 Perfume 0.9 Sodium lauryl sulfate 0.7 Adjusted to water 100 Strengthening of astringent activity of toothpaste obtained When measured in the same manner as in Example 1, it was 157%.

Example 3 A toothpaste was manufactured according to a conventional method according to the following formulation.

Ingredient content (%) Dibasic calcium phosphate 40.0 Sorbitol 20.0 Glycerin 10.0 Carrageenan 1.0 Sodium lauryl sulfate 1.2 Sodium saccharin 0.2 Ascorbic acid 0.05 Aluminum lactate 0.5 Perfume 1.0 Adjusted to 100% water Example of increasing astringent activity of toothpaste When measured in the same manner as in 1, it was 162%.

Example 4 A mouse ash was produced according to a conventional method according to the following formulation.

Ingredient content (%) Ethyl alcohol 25.0 Glycerin 5.0 Ascorbic acid 0.03 Aluminum lactate 1.0 Sodium saccharin 0.05 Perfume 1.0 Adjusted to 100% water The astringent activity of the toothpaste obtained was measured in the same manner as in Example 1. It was 137%.

Example 5 A toothpaste was produced according to a conventional method according to the following formulation.

Component content (%) Sodium lauryl sulphate 3 Ethyl alcohol 5 Methylcellulose 2 Sodium saccharin 0.1 Sodium ascorbate 0.05 Aluminum lactate 0.1 Perfume 0.3 Adjusted to 100% water It was 173% when measured.

Example 6 An oral pasta was produced according to a conventional method according to the following formulation.

Ingredient content (%) Polyoxyethylene monostearate 3 Sorbitan monooleate 2 Cetyl alcohol 5 Propylene glycol 15 Hydroxyethyl cellulose 5 Sodium saccharin 0.2 Fragrance 0.3 Aluminum lactate 1.5 Ascorbic acid 0.45 Adjusted to 100% water Obtained oral pasta The astringent activity enhancement rate of 177% was 177%.

Claims (3)

[Claims] 1. An oral composition containing aluminum lactate, which comprises ascorbic acid or a sodium salt thereof. 2. The oral composition according to claim 1, wherein the content of aluminum lactate is 0.1 to 2% by weight based on the total weight of the composition. 3. The oral composition according to claim 1 or 2, wherein the ascorbic acid or its sodium salt content is 3 to 50% by weight based on the content of aluminum lactate.