JPS5988417A - Dentifrice composition - Google Patents

Abstract

PURPOSE:The titled composition, containing a powdered zedoary or an extract thereof with an aqueous solvent as an active constituent, and capable of exhibiting improved effect on prevention and treatment of periodontitis, e.g. pyrrhoea alveolaris or gingivitis, etc. CONSTITUTION:A dentifrice composition containing a powdered zedoary (Curcuma zedoaria Roscoe) or an extract thereof with an aqueous solvent, e.g. ethanol, as an active constituent. Periodontitis is generally started in the inflammation in the periodontal tissue to cause the redness, swelling and bleeding of the gum, and chronic progress thereof forms the so-called periodontal pocket between teeth. Thus, the deflection of teeth and bad breath are caused to proceed into pyrrhoea alveolaris. The continuous use of the powdery zedoary by the oral smearing has an effect on the anti-inflammation of the periodontal tissue, and the periodontal pocket is reduced to tighten the gum and stop the bleeding. The amount of the zedoary to be incorporated is preferably 0.1wt% or more based on the dentifrice composition.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition, and more particularly to a dentifrice composition that exhibits excellent effects in preventing and treating periodontal diseases such as alveolar pyorrhea and gingivitis.

Periodontal disease generally begins with inflammation of the periodontal tissues, resulting in redness, swelling, and bleeding of the gums, and when this progresses chronically, so-called periodontal pockets form between the teeth, causing tooth movement and bad breath. This causes pyorrhea, which progresses to alveolar pyorrhea, and its prevention and treatment are extremely important issues from the viewpoint of oral hygiene.

Conventionally, it has been proposed to incorporate various medicinal agents into toothpaste in order to prevent and treat such periodontal diseases, and some have been put into practical use. Shigashinaka G1 It cannot be said that the medicinal agents that have been proposed so far are fully satisfactory.

While conducting various research on herbal medicines, the inventors of the present invention unexpectedly found that by combining gajutsu with toothpaste and using it continuously,
It has been found that it is highly effective in preventing and treating periodontal disease. Namely, Gajutsu<81, Curcuma
Zedoaria Roscoe) is a crude drug listed in the Japanese Pharmacopoeia, and has been used as an aromatic and stomachic medicine, and there have been no examples of its use in the dental field. However, surprisingly, it has been found that continuous oral application of gajutsu has the effect of extinguishing inflammation of the periodontal tissue, reducing the size of periodontal pockets, tightening the gums, and stopping bleeding.

The present invention has been completed based on such knowledge, and provides a dentifrice composition containing zeju powder or an aqueous solvent extract of zeju as an active ingredient. , exhibits excellent preventive and therapeutic effects on periodontal disease.

The gaju powder to be used may be ground dried gaju rhizome, which is known as a herbal medicine, and is preferably finer than 40 mesh from the viewpoint of the feel of toothpaste. The aqueous solvent extract of kajutsu is, for example, an extract obtained by extracting finely chopped kajutsu powder or dried rhizome of kajutsu with water or an aqueous solvent such as 30% ethanol at 15 to 25°C according to a conventional method. That's fine.

From the viewpoint of its effectiveness, it is preferable that such kajutsu powder or extract be blended in a dentifrice composition in an amount of 0.1% (wt%, same hereinafter) or more. The upper limit of the blending amount is not particularly limited, and can be appropriately selected depending on the desired properties of toothpaste.

The dentifrice composition of the present invention can be prepared by using conventional methods such as toothpaste powder, toothpaste,
It can be in the usual dosage form such as cream, pasta, water toothpaste, etc. Other ingredients are not particularly limited, and include commonly used abrasives, foaming agents, wetting agents, binders, sweeteners, and preservatives. ingredients, fragrances, etc. can be added as appropriate. It is also possible to use other medicinal agents such as fluoride, chloride, etc.

Next, the present invention will be explained in more detail with reference to Preparation Examples and Examples.

Preparation Example Preparation of Gejutsu Extract 1 kr of dried rhizome of Gejutsu is cut into small pieces, 20 tons of 30% aqueous methanol is added, and the mixture is extracted by carbonization for 2 hours, and this operation is repeated again. A large amount of the extract is collected and concentrated under reduced pressure to prepare a soft extract with a water content of 30% (yield 8.3%).

Example 1 A powdered toothpaste was manufactured according to the conventional method using the following recipe.

Ingredients % Gadget powder <40 mesh) 98.9 Flavor 1.0 Saccharin 0.1 Example 2 A toothpaste powder was produced according to the conventional method using the following formulation.

Ingredients % Calcium carbonate 75.0 Glycerin 10.0 Sodium lauryl sulfate 1.3 Gajiyutsu extract
1.0 fragrance
1.0 Saccharin 01 Ethyl paraoxybenzoate 0.005 Water
Remaining Example 3 A toothpaste was manufactured according to the conventional method using the following formulation.

Ingredients % Calcium carbonate 39. .

Nruvit 22.0 Sodium carboxymethylcellulose 11 Sodium lauryl sulfate 1.3 Gajiyutsu extract 0.8 Fragrance
1゜Saccharin
o1 Ethyl paraoxybenzoate 0.01 Water Balance The powdered toothpaste of Example 1 was used to test its effect on improving periodontal disease.

(1) Subjects A total of 61 men and women (age 11 to 54) were used as subjects, including those with visible periodontal pockets, those with bleeding gums, those with discolored gums, and those with bad breath.

(2) Test method Each subject brushed their teeth with the powdered toothpaste of Example 1 twice every day, before going to bed and after breakfast, and two months later, the improvement effect on symptoms was evaluated.

(3) Evaluation Each symptom was classified as follows, and the condition before and after toothpaste use was observed, and 2-level improvement was considered effective, 1-level improvement was considered harmonious, and no improvement or worsening was considered invalid.

Symptom 1: There are pockets around the teeth, constant bleeding and strong bad breath, and the gums are slightly dark red in color.

Symptom 2: The pockets around the teeth are not clearly visible, but there is some light bleeding and bad breath, and the gums are deep red.

Symptom 3: The gums are tight, but they bleed when brushing too hard, and sometimes there is bad breath. The color of the gums is light red.

Symptom 4: The gums are well-tight, there is no bleeding or bad breath, and the color of the gums is bright red.

In addition, the test subject's symptoms did not necessarily have all of the conditions in each section of Symptoms 1 to 4, but had at least two conditions.

(4) Results Out of 61 subjects, 42 were found to be effective (68,
9%), 16 (262%) were recognized as having a wa-do, and 3 (49%) were found to be ineffective.

No cases of exacerbation were observed while the drug was ineffective.

From these results, it is clear that the dentifrice composition of the present invention exhibits excellent periodontal disease improving effects when used continuously, even for a relatively short period of two months. During this test, extremely noticeable effects were observed in tightening the gums and brightening the color of the gums (improving blood circulation).

Patent applicant: Osaka Pharmaceutical Research Institute Co., Ltd.

Claims (1)

[Claims] (1) A toothpaste composition characterized in that it contains Kajutsu powder or an aqueous solvent extract of Kajutsu as an active ingredient.