JP2003026557A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new composition for the oral cavity, especially a tooth paste composition, having effects of the prevention and treatment of periodontosis and tooth caries, containing basically a natural plant-originated component as an active ingredient, without a fear of adverse effect, capable of being used by a sick person, an old person, a child, etc., safely and securely. SOLUTION: This composition for the oral cavity, especially the tooth past composition contains a zedoary, Denshichi ginseng and further raffinose, an herb and/or aloe extract.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a dentifrice composition such as toothpaste, toothpaste and liquid dentifrice, and an oral composition such as mouthwash, denture cleaner and chewing gum. More specifically, it is a natural plant. The present invention relates to an oral composition, in particular, a dentifrice composition, which is based on a derived component and does not contain an abrasive of a mineral substance and can be safely used by sick people, elderly people, children and the like.

[0002]

2. Description of the Related Art Conventionally, the cause of periodontal disease and tooth decay is said to be periodontal disease bacteria such as Bacteroides gingivalis in dental plaque and caries fungi such as mutans bacteria. Various agents effective in decomposing plaque have been used as medicinal components of various oral compositions such as dentifrice compositions and mouthwashes.

However, in recent years, it has begun to be said that the true cause of periodontal disease and tooth decay is Candida albicans, which is a kind of fungus (mold), and particularly Candida albicans, rather than the above-mentioned bacteria. The use of syrup of amphotericin B, which is an antifungal agent effective for removal, as a dentifrice has come to be used in part. However, since amphotericin B is an antifungal agent, the possibility of side effects cannot be ignored, and there is a problem that it is difficult to continue using it for a long period of time.

In addition, conventional oral compositions, especially dentifrice compositions, include abrasives such as calcium hydrogen phosphate and silicic acid anhydride for removing stains adhering to the surface of teeth and cleaning effects. A surfactant is used as a foaming agent. However, when it comes to abrasives, conventionally used abrasives are hard minerals themselves, so if you polish too hard, you may damage the enamel of your teeth,
There was a drawback that it might wear teeth.
In addition, some surfactants as effervescent agents have been pointed out to be toxic, so it is necessary to prevent accidental ingestion.
In any case, conventional oral compositions, especially toothpaste compositions, have not always been safe to use.

[0005]

The present invention solves the above problems, is effective in the prevention and / or treatment of periodontal disease and tooth decay, and basically uses natural plant-derived ingredients as active ingredients. It is an object of the present invention to provide a novel oral composition, especially a dentifrice composition, which can be safely used by sick people, elderly people, children and the like without fear of side effects.

[0006]

Means for Solving the Problems As a result of repeated studies to solve the above problems, the present inventor has found that banyan nuts, which have long been used as medicinal herbs, have a strengthening action on oral mucosa, periodontal disease and It has a preventive and / or therapeutic effect on dental caries, removal and prevention of bad breath, bactericidal and antiseptic effect, stomachic effect, and polishing effect without damaging or abrading the tooth surface. The known Tanachi has hemostatic action, blood flow improving action, and antifungal action. When both are used together, it has the action of suppressing fungi such as Candida, and it may damage or wear teeth. The present invention has been completed by finding that a novel oral composition, especially a toothpaste composition, which has the effect of polishing the tooth surface without a tooth, can be obtained.

That is, the present invention solves the above-mentioned problems by providing a composition for oral cavity containing Gautu and Tadachi.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION
It is a medicinal herb that is also included in the Chinese herbology classic "Honzotsuna", and the rhizome of the perennial ginger family of the Indian and Himalayan origins known as Curcuma Zedalis Roscoe is sliced, dried and powdered. It is used as a zedoary powder or as an extract from the rhizome.

The amount of gauze in the oral composition of the present invention is usually about 1 to 10 w / w%, preferably 2 to 8 w / w% in terms of solid content. If the amount of zedoary is less than 1 w / w%, the desired effects cannot be obtained, and
If it exceeds 10 w / w%, there is a disadvantage that the bitterness is increased and the usability is impaired. As described above, the zedoary has a bitter taste, and until now it was thought that it could not be used for those that are retained in the oral cavity for a long time like the oral composition, but the present inventors newly found it. According to the knowledge, it can be used surprisingly without causing any discomfort. Also,
In particular, when used in combination with sweeteners such as stevioside and honey, and sugars such as D-sorbitol, xylitol, and raffinose, the sweetness effectively eliminates the bitterness of zedoary, and oral compositions, especially It can be preferably used for a toothpaste composition. On the other hand, Gazoutu also contains cineole, sesquiterpenes such as camphors and azulene, flavone-based glycosides, etc., and has the effect of preventing periodontal disease and tooth decay, and the effect of removing bad breath, and further , Inhibitory effect against Staphylococcus aureus and β-type hemolytic streptococcus, stomachic effect, bactericidal / antiseptic effect, anti-inflammatory /
As it has anti-ulcer and anti-pepsin effects, it also has a therapeutic effect on aphthous stomatitis. In addition, the zedoary powder or zedoary extract contains a lot of plant fibers, and when used in a toothpaste composition, while having the effect as an abrasive for polishing the tooth surface, a conventional toothpaste composition. Unlike the abrasives contained in objects, it has the characteristic of not damaging or abrading the tooth surface.

[0010] The term "Tanachi" used in the present invention is a perennial herb of the genus Ginseng, also known as Radix Notoginseng, which contains saponin glycosides and contains ginsenoside as a main component. . There are many unknowns about the detailed pharmacological action of Tanachi, but hemostasis action from a long time ago, it has been reported antifungal action, using the oral composition of the present invention, in particular a dentifrice composition, hemostatic action, To improve blood flow,
It not only tightens the gums, but also exerts an antifungal effect and suppresses Candida. The amount of Tanachi in the oral composition of the present invention is usually 1 to 10 w / w% in terms of solid content.
Degree, preferably in the range of 2 to 8 w / w%. If the amount of Tanachi is less than 1 w / w%, the desired effects cannot be obtained,
On the other hand, if it exceeds 10 w / w%, there is a disadvantage that the bitterness is increased and the usability is impaired.

As long as the desired effect is achieved, the proportion of banyan nuts and Tachichi contained in the oral composition of the present invention is
The weight ratio is not particularly limited, but in terms of weight ratio, 1 gautu is 0.37 to 2 fields, preferably 1 gautu to 70 fields.
It is a ratio of 5 to 1.5.

The oral composition of the present invention may further contain raffinose in addition to the above components. Raffinose used in the present invention means D-galactose,
It is a trisaccharide composed of D-glucose and D-fructose, which is present in beet, sugar cane, soybean, honey, cabbage, yeast, potato, grape, various wheats, corn, seeds of many legumes, etc. Since it is an oligosaccharide that has been ingested in the diet, it is an extremely safe food material. Raffinose is an oligosaccharide highly selective assimilated by bifidobacteria and lactobacilli, and is effective in increasing bifidobacteria, improving intestinal flora and faecal properties, and having an antioxidant action. However, in addition to having the effect of strengthening the mucous membrane in the oral cavity, it is recently said that it is also effective for atopic dermatitis.

The raffinose used in the present invention is not limited in origin, production method, purity and the like as long as it is used in the oral composition of the present invention and exhibits desired effects. As a method for obtaining raffinose, for example, in a sugar-making step from beet, it is separated and collected by chromatography from beet molasses containing sucrose, and concentrated and purified by crystallization. The raffinose obtained has a high purity and can be preferably used in the present invention.

The amount of raffinose in the oral composition of the present invention is usually about 1 to 30 w / w%, preferably 3 to.
It is in the range of about 10 w / w%. The amount of raffinose is 1
If it is less than w / w%, the desired effects cannot be obtained, and 3
Even if it exceeds 0 w / w%, no significant difference is seen in the action and effect.

Herbs can be included in the oral composition of the present invention. The herbs used in the present invention are medicinal herbs or extracts thereof, and any herb may be used as long as it can exhibit the action as an herb, citrus herbs, lavender, Also, it is preferable to use one kind or two or more kinds selected from mint herbs. Citrus herbs include bitter orange, sweet orange, grapefruit, lemon, mandarin, bergamot and other citrus herbs, while mint herbs include peppermint, anise, spearmint, cinnamon, coriander, fennel and other mint herbs. Herbs are mentioned, but peppermint is particularly preferable. These herbs have a refreshing and aroma-providing effect, as well as an anti-infective effect, an antiviral effect,
It has an antibacterial action, an antiparasitic action, and an antifungal action against fungi such as Candida. When used in an oral composition, it suppresses or prevents the growth of fungi in the oral cavity, strengthens the gingiva, and It is effective in preventing and / or treating periodontal disease and tooth decay. Usually, the amount of the herbs blended in the oral composition of the present invention is preferably about 0.01 to 2 ml per 100 g of the oral composition.

Aloe extract can also be used in the oral composition of the present invention. The aloe extract has an astringent action, an antibacterial action, and a bactericidal action, and when used in the oral composition of the present invention, particularly a toothpaste composition, tightens the gingiva and prevents and / or prevents periodontal disease and caries. Or, there is an effect of treating. There is no particular limitation on the aloe extract that can be used, but for example, extracts such as aloe vera, aloe vera, and cape aloe can be used. Usually, the amount of the aloe extract blended in the oral composition of the present invention is preferably about 10 to 30 w / w% with respect to the oral composition.

As described above, the zedoary, field seven, raffinose, herbs and aloe extract used in the present invention are
Since all of them are derived from natural plants that humans have eaten since ancient times, and have been used as extremely safe herbs, there are no side effects. In addition, guajtu contains saponin and has a polishing effect, a bad breath removal effect, and a bad breath prevention effect. Tabachi and herbs suppress fungi such as Candida, and can cure periodontal disease and tooth decay and / Or, since they have a preventive effect, when these are used as an active ingredient in a composition for oral cavity, particularly a composition for toothpaste, it has an effect of preventing and / or treating periodontal disease and tooth decay, and a halitosis removing and halitosis preventing effect. Since the tooth surface is obtained and the tooth surface can be kept smooth and beautiful by the polishing action of the gauze, a foaming agent such as a surfactant is also unnecessary. In addition, Gajutsu, Tadachi and Raffinose have an antioxidant effect, and are effective in strengthening the mucous membrane in the oral cavity and gingiva.

In addition, Gautu has a gastrointestinal harmonization action, a liver damage suppression action, a blood purification action, etc., and Tanachi has a cardiotonic action, a blood flow improving action, a fatigue recovery action, and further, raffinose Since it has an effect of improving the intestinal flora and improving fecal property by increasing the amount of bifidobacteria, the oral composition of the present invention, particularly the dentifrice composition, even if swallowed after use, of those blending components It also has the epoch-making merit that various effects in the body can be expected.

In addition to the above-mentioned active ingredients, the oral composition of the present invention may contain various other commonly used ingredients as long as the object of the present invention is not impaired. For example, thickeners such as xanthan gum and agar, sweeteners such as stevioside and honey, sugars such as D-sorbitol, xylitol and raffinose, antioxidants such as ascorbic acid and vitamin E, fragrances such as menthol, peppermint and citrus extract. Astringents such as sage extract and rosemary extract, and enzymes such as dextranase, mutanase, protease and lysozyme chloride. Ascorbic acid has an effect of tightening the gingiva and strengthening the mucous membrane in the oral cavity in addition to the antioxidant effect. Also, if necessary,
Conventionally used medicinal components such as chlorhexidine hydrochloride and cetylpyrimidinium chloride may be added. In the oral composition of the present invention, it is preferable not to use an emulsifier, but in some cases, an emulsifier such as sorbitan fatty acid ester may be used.

Xanthan gum and agar are preferably used in combination as a thickening agent for use in the oral composition of the present invention, particularly in the dentifrice composition. Both xanthan gum and agar are vegetable components and are safe. Moreover, xanthan gum and agar are both soluble in the oral cavity, but if agar is used in addition to xanthan gum, it does not become sticky in the oral cavity and, in addition to providing an excellent feeling of use, gargling after brushing is essential. It has the characteristic of disappearing. In addition, there is a feature that the taste of food does not change even after use. The amount of agar and xanthan gum used varies depending on the form of the dentifrice composition and other coexisting components, but is usually 1 to 5 w / w% agar and 1 xanthan gum to the dentifrice composition.
The range of up to 5 w / w% is preferred. In addition, a preferable amount ratio of agar and xanthan gum is within the range of the above-mentioned preferable amount of use, and it is preferable to appropriately arrange the amount, and 0.5 to 2 parts by weight of xanthan gum per 1 part by weight of agar. The range is preferable, and particularly preferable is 2 parts by weight of xanthan gum to 2.5 parts by weight of agar.

The oral composition of the present invention can be produced by a conventional method. Gajutsu and Tachichi may be prepared by appropriately mixing and blending the extracted extract or powder with other raw materials, and raffinose may be mixed and blended with other raw materials in powdered or granular form, or in purified water or the like. You may mix | blend in a melted state. In addition, herbs such as citrus herbs, lavender, mint herbs and aloe extract,
It suffices to appropriately mix and blend the material having an appropriate form with other raw materials. The oral composition of the present invention may be in the form of powder, paste, liquid or solid.

Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the dentifrice composition of the present invention is not limited to those described in Examples.

Example 1 A dentifrice composition was prepared as an oral composition of the present invention in the following manner with 100 g of a dentifrice composition according to the following formulation. Gautu extract (2.5 g of gauze added to 100 parts by weight of purified water and extracted by heating) 2.5 g (weight of solid gauze before extraction) Tanachi extract (Tanachi 2 per 100 parts by weight of purified water) 2.5 g (weight of Tana solid content before extraction) Raffinose (“Raffinose 100” manufactured by Nippon Beet Sugar Co., Ltd.) 5 g Xanthan gum 2 g Agar (trade name “Ultra Agar” Ina) Food Industry Co., Ltd.) 2.5 g Peppermint 0.4 ml D-sorbitol 15 g Purified water balance

The resulting dentifrice composition had no bitter taste bitterness and gave a refreshing feeling of use. Also,
Gaduz also acts as an abrasive, so
It has a polishing effect on the tooth surface without using any special polishing agent. This dentifrice composition contains Tanachi, peppermint, and therefore has a good fragrance, removes and suppresses fungi such as Candida, and cures or prevents periodontal disease, prevents tooth decay, and further removes halitosis and It exerts an anti-infection action, an anti-viral action, an anti-bacterial action, and an anti-parasitic action as well as the effect of prevention. Moreover, since agar and xanthan gum are used together as a thickening agent, it does not become sticky in the oral cavity and is excellent in the feeling of use, and it does not contain a surfactant, so that gargle after tooth brushing is unnecessary. Further, it is an epoch-making dentifrice composition that can be swallowed as it is after brushing the teeth, and the taste of food does not change after use, and can be safely and safely used by sick people, the elderly and children.

Example 2 A dentifrice composition was prepared as an oral composition of the present invention in the following manner with 100 g of a dentifrice composition according to the following formulation. Gautu extract (2.5 g of gauze added to 100 parts by weight of purified water and extracted by heating) 2.5 g (weight of solid gauze before extraction) Tanachi extract (Tanachi 2 per 100 parts by weight of purified water) 2.5 g (weight of Tana solid content before extraction) Raffinose (“Raffinose 100” manufactured by Nippon Beet Sugar Co., Ltd.) 5 g Xanthan gum 2 g Agar (trade name “Ultra Agar” Ina) Food Industry Co., Ltd.) 2.5 g lavender 0.4 ml D-sorbitol 15 g purified water balance

The obtained dentifrice composition had no bitter taste and gave a refreshing feeling of use. Also,
Gaduz also acts as an abrasive, so
It has a polishing effect on the tooth surface without using any special polishing agent. This dentifrice composition contains Tanachi and lavender, so it has a good fragrance, removes and suppresses fungi such as Candida, cures and prevents periodontal disease, prevents tooth decay, and further removes halitosis and It exerts an anti-infection action, an anti-viral action, an anti-bacterial action, and an anti-parasitic action as well as the effect of prevention. Moreover, since agar and xanthan gum are used together as a thickening agent, it does not become sticky in the oral cavity and is excellent in the feeling of use, and it does not contain a surfactant, so that gargle after tooth brushing is unnecessary. Further, it is an epoch-making dentifrice composition that can be swallowed as it is after brushing the teeth, and the taste of food does not change after use, and can be safely and safely used by sick people, the elderly and children.

Example 3 A dentifrice composition was prepared as an oral composition of the present invention in the following manner with 100 g of a dentifrice composition according to the following formulation. Gautu extract (3 parts by weight of gauze added to 100 parts by weight of purified water and extracted by heating) 3 g (weight of solid content of gauze before extraction) Tanachi extract (added 3 parts by weight of Tanachi to 100 parts by weight of purified water) Heat-extracted) 3 g (weight of Tana solid content before extraction) Raffinose (“Raffinose 100” manufactured by Nippon Beet Sugar Co., Ltd.) 5 g Xanthan gum 2 g Agar (trade name “Ultra Agar” manufactured by Ina Food Industry Co., Ltd.) 5g Bitter orange 0.4ml Vitamin E 1g Emulsifier 1g Purified water balance

The obtained dentifrice composition had no bitter taste and gave a refreshing feeling of use. Also,
Gaduz also acts as an abrasive, so
It has a polishing effect on the tooth surface without using any special polishing agent. Since this dentifrice composition contains Tanashi and Bitter Orange, it has a good fragrance, removes and suppresses fungi such as Candida, cures and prevents periodontal disease, prevents tooth decay, and further removes bad breath. In addition to exerting a preventive effect, it also exhibits an anti-infection action, an anti-viral action, an anti-bacterial action, and an anti-parasitic action. In addition, since it contains vitamin E, it has a characteristic that it has an effect of tightening the gums, has an antioxidant effect, and is suitable for long-term storage. Moreover, since agar and xanthan gum are used together as a thickening agent, it does not become sticky in the oral cavity and is excellent in the feeling of use, and it does not contain a surfactant, so that gargle after tooth brushing is unnecessary. Further, it is an epoch-making dentifrice composition that can be swallowed as it is after brushing the teeth, and the taste of food does not change after use, and can be safely and safely used by sick people, the elderly and children.

Example 4 The dentifrice composition obtained in Example 1 was used as a normal dentifrice composition twice daily in the morning and evening for a total of 30 healthy adult male and female volunteers for one week. When used in a similar manner, the composition for dentifrice obtained in Example 1 from all 30 people does not contain a surfactant as a foaming agent, and thus it is not necessary to gargle after use. In addition to not feeling it, a few days after the start of use, it was answered that the sticky feeling in the oral cavity upon waking up in the morning disappeared. Also,
All 30 people answered that when the dentifrice composition obtained in Example 1 was used, the tooth surface was kept smooth and smooth even when getting up.

[0030]

As described above, according to the composition for oral cavity of the present invention, in particular, the composition for toothpaste, it is derived from banyan nuts and field bunches which have been used as medicinal herbs since ancient times, and plants which have been conventionally used for food. Since it contains raffinose and further herbs and / or aloe extract as an active ingredient, it can be used for a long time without worrying about side effects, does not cause inconvenience due to accidental ingestion, and is safe for sick people, the elderly and children. It is an excellent oral composition that can be used with confidence. Further, the composition for oral cavity of the present invention, particularly the composition for dentifrice, has an effect on healing and prevention of periodontal disease, prevention of tooth decay, and further removal and prevention of halitosis, as well as an anti-infective action and an antiviral action. , Exhibits antibacterial action and antiparasitic action. In addition, gadgets also have an action effect as an abrasive, and when used in a toothpaste composition, there is an advantage that an abrasive effect can be achieved without damaging or abrading the tooth surface.

In addition, when gyakutu is used in combination with sweeteners such as honey and stevioside, and sugars such as D-sorbitol, xylitol and raffinose, the bitterness of the zedoary is counteracted and a feeling of use as an oral composition is obtained. Thus, it is possible to use the zedoary gauze having an excellent action effect in an oral composition, particularly a dentifrice composition, without impairing the above. Moreover, each active ingredient in the composition for oral cavity of the present invention is conventionally known to exhibit excellent action and effect in the body.
When the oral composition of the present invention is a dentifrice composition,
It is also possible to expect various action effects of Gautu, Tadachi, and Raffinose in the body by swallowing after brushing the teeth. Further, since the toothpaste composition as the oral cavity composition of the present invention uses xanthan gum and agar together as the thickening agent, it does not become sticky in the oral cavity and is excellent in usability. As described above, the oral composition of the present invention, in particular, the dentifrice composition has various excellent effects which the conventional oral compositions do not have, and is an extremely epoch-making invention.

Claims (6)

[Claims] 1. A composition for oral cavity containing gauze and Tadachi. 2. The oral composition according to claim 1, further comprising raffinose. 3. The oral composition according to claim 1, further comprising an herb and / or an aloe extract. 4. The oral composition according to claim 3, wherein the herbs are one or more selected from citrus herbs, lavender, and mint herbs. 5. The composition for oral cavity according to claim 1, 2, 3 or 4, which comprises agar and xanthan gum. 6. A dentifrice composition, claim 1, 2, 3,
The composition for oral cavity according to 4 or 5.