JP4761017B2 - Oral patch for bad breath suppression - Google Patents

Description

The present invention has high bad breath prevention and suppression effect, moreover relates mouth odor suppression intraoral patch persistence is improved in its effect.

The bad breath is methyl mercaptan, hydrogen sulfide, or the like generated by decomposing oral dirt (food residue, exfoliated mucous membrane, etc.) by the bacteria that cause bad breath. Conventional bad breath prevention includes (1) capture and deodorization of methylcaptan, (2) removal of bad breath causing bacteria, (3) inhibition of enzymes that cause bad smell of bad breath causing bacteria (bacterial metabolism inhibition), (4) salivation There were methods such as removal of dirt by enhancement. However, in (1), it is fast-acting but does not last. In (2), it kills the bacteria, which may disturb the oral flora, but in (3) it is persistent. The bad breath that has occurred is ineffective, and in (4), the bad breath that is generated after pouring dirt with saliva is not effective.
In addition, the following are mentioned as prior literature relevant to the present invention.

JP-A-57-204278 JP 58-134013 A JP 59-103665 A JP 59-203445 A Japanese Patent Laid-Open No. 60-77763 JP-A-8-92050 Japanese Patent Laid-Open No. 10-182392 Japanese Patent Laid-Open No. 11-180839 JP-A-11-228367 JP 2000-350777 A JP 2002-3353 A JP 2003-26527 A JP 2003-40752 A Special table 2003-528902 Journal of Japanese Society of Food Industry 38 (12), 1991, p1098-1102

The present invention is, bad breath preventive effect, excellent halitosis inhibiting effect, moreover an object to provide a sustained high mouth odor suppression intraoral adhesive preparation of the effect.

  As a result of intensive studies to achieve the above-mentioned object, the present inventors have combined use of a citrus plant or an extract thereof with a citrus plant or an extract thereof, in particular, a seed of the citrus family Salamander or an extract thereof. As a result, it has been found that the bad breath suppressing effect is remarkably increased, and that the bad breath suppressing effect can be satisfactorily exhibited after application in the oral cavity, thereby improving the rapid efficacy and sustainability. Furthermore, a flavor is good by mix | blending 1 type (s) or 2 or more types among the plant of Coriaceae cola or its extract, the plant of the cucurbitaceae rosaceae fruit or its extract, menthol or its derivative, a sweetener, and a fragrance | flavor. It has been found that an intraoral composition, particularly an intraoral patch, can be obtained, and the present invention has been made.

That is, the present invention provides a halitosisinhibition for intraoral patch below.
[1]. (A) A bad breath consisting of a plant of Lamiaceae selected from rosemary, sage, thyme, marjoram, melissa, perilla, oregano, basil, naginata, or extract thereof; and (B) a salamander seed or extract thereof. An intraoral patch for suppressing bad breath, comprising an inhibitor .
[2 ]. The oral patch for bad breath suppression according to [ 1 ], wherein the content of the component (A) is 0.01 to 10% by mass and the content of the component (B) is 0.01 to 10% by mass.
[ 3 ]. Furthermore, as component (C), [ 1 ] or [ 2 ], wherein one or two or more selected from a plant composed of Coriaceae cola and an extract thereof, a plant composed of Cucurbitaceae rosaceae and an extract thereof, is blended. Oral patch for suppressing bad breath.
[ 4 ]. Furthermore, the oral patch for oral malodor control according to any one of [ 1 ] to [ 3 ], which contains tocotrienol and / or laccase.
[ 5 ]. Furthermore, the oral patch for bad breath suppression in any one of [ 1 ]-[ 4 ] which mix | blended menthol or its derivative (s) as (D) component .

  According to the present invention, it is possible to obtain a combined effect of catching bad breath by a Labiatae plant or an extract thereof and inhibiting the metabolism of bad breath causing bacteria by the seeds of the Citrus Salamander plant or an extract thereof, and having a high bad breath suppressing effect, It has excellent rapidity and sustainability. Furthermore, the bad breath prevention preparation which improved the taste can be provided by mix | blending 1 type (s) or 2 or more types among the plant of Aogiri family cola, its extract, menthol or its derivative (s), a sweetener, and a fragrance | flavor.

  As the Labiatae plant of component (A) used in the present invention or an extract thereof, conventionally known ones can be used, for example, sage, rosemary, thyme, marjoram, melissa, perilla, oregano, basil, naginatakouju It is possible to use a material obtained by pulverizing leaves and stems as raw materials, and extracting the powdered Lamiaceae plant, a polar solvent and / or a nonpolar solvent (for example, water) , Ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol and other polar solvents, or n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane , Nonpolar solvents such as toluene and benzene, or mixed solvents thereof) Extracts obtained by subjecting a raw material selected from the extract obtained by extraction and the extraction residue to solvent extraction, and carnosol, carnosic acid, 7,11,12-tri isolated from the above plant Deodorizing active ingredients such as hydroxy-6,10- (epoxymethano) abieta-8,11,13-trien-20-one (Rosmanol) and salts thereof (JP 57-203445, JP 57-204278 and JP-A-59-103665). Of these, sage, rosemary, thyme, marjoram, melissa, perilla and extracts thereof are preferred. The solvent used in the solvent extraction treatment may be an organic solvent or an inorganic solvent as described in the above publication, or may be a mixed solvent of an organic solvent and an inorganic solvent. Specific examples of the organic solvent include ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2 -Dichloroethane, toluene, benzene and the like. As the inorganic solvent, water, and an aqueous solution of acid, alkali or a salt thereof can be used. Specifically, hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid, carbonic acid, sodium hydroxide, potassium hydroxide, ammonium hydroxide, water Examples include calcium oxide, sodium chloride, potassium chloride, ammonium chloride, sodium bicarbonate, sodium carbonate, sodium sulfate and the like. These acids, alkalis and salts are preferably used at a concentration of 2 mol or less. Preferred solvents are water, lower alcohols having 1 to 3 carbon atoms, and polyhydric alcohols. Moreover, it is preferable that the usage-amount of the solvent quoted above shall be equal capacity or more with respect to a raw material.

  Component (B), salamander seed or extract thereof, is made from seeds of Zanthoxylum plants, pulverized into powder, or a polar solvent and / or nonpolar An extract extracted with a solvent. In particular, an extract containing a water-insoluble fraction, or 2,6-dimethyl-3,7-octadiene-2,6-diol, 2,6-dimethyl-1,7-octadiene-3,6-diol, -Acetoxy-1-p-mentene, 8-acetamino-1-p-mentene, 11-hydroxy-8-eudesmen, unsaturated fatty acid having 16 or more carbon atoms, unsaturated aldehyde having 6 or more carbon atoms Those containing as an active ingredient are preferred.

  In this case, as the solvent, polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, or n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, Nonpolar solvents such as chloroform, dichloromethane, 1,2-dichloroethane, toluene, and benzene, or a mixed solvent thereof can be used, and an extract obtained by extracting the above raw materials by a usual extraction method can be used. .

  In the case of an extract containing a water-insoluble fraction, as described in JP-A No. 2003-26527, as a solvent, methanol, ethanol, butanol, hexane, heptane, cyclohexane, ethyl acetate, acetone, etc. In general, the organic solvent can be used, and one of these can be used alone or in admixture of two or more, and in the case of a water-soluble solvent, it can be used as a hydrous solvent. Among these solvents, methanol, ethanol, hydrous alcohol and the like are particularly preferable, and hydrous ethanol solution containing 10 to 50% of water is particularly preferable. In addition, extraction processing can be normally performed at a temperature of about 3-70 degreeC by a conventional method.

  When the components (A) and (B) are blended in the oral composition, the blending amount is 0.001 to 50% (mass%, the same applies hereinafter) of the whole composition, particularly 0.01 to 10%. If it is less than this, a satisfactory effect may not be exhibited, and if it exceeds 50%, the stability or flavor of the composition may be impaired. Further, the blending ratio of the component (A) and the component (B) is preferably 1: 1,000 to 1,000: 1, particularly 1: 100 to 100: 1 as a mass ratio. May not be effective. Among these plants and extracts thereof, preferred combinations of combinations are rosemary and salamander plants or extracts thereof, sage and salamander plants or extracts thereof, Melissa and salamander plants or extracts thereof. , Thyme and salamander plants or extracts thereof, particularly preferred are rosemary and salamander plants or extracts thereof, sage and salamander plants or extracts thereof.

  Furthermore, the oral composition of the present invention can be blended with one or two or more species selected from plants of the family Coleaceae cola and cucurbitaceae and their extracts, and this formulation enhances salivary secretion, The effect of improving the unpleasant taste that remains can be given. Here, as a plant or an extract of Coleaceae cola, a cola tree seed is used as a raw material, and it is from a tree belonging to cola tree called Kola acuminata (scientific name: Cola acminata) and Kola nitida (scientific name: Cola unitida A. Chev.) The seeds to be collected are pulverized and powdered, or an extract thereof. In addition, as a plant or extract of the cucurbitaceae rosaceae fruit, a fruit of scientific name: Mormodica grosvenori Swingle is used as a raw material, and its chip, powder, or an extract obtained by extracting it with a solvent can be used. In addition, as a solvent, the solvent illustrated by the preparation of the extract of the said Lamiaceae plant and a salamander seed is mentioned. Each blending amount is preferably 0.001 to 50% of the entire composition, particularly preferably 0.01 to 10%. If less than this, a satisfactory effect may not be exhibited. The stability or flavor of the product may be impaired.

  When these colas, rahan fruit or extracts thereof are added, preferred combinations of combinations are rosemary and salamander and corae plants or extracts thereof, sage and salamander and corae plants or extracts thereof, Melissa and Salamander and Collae plant or extract thereof, Thyme and Salamander and Collae plant or extract thereof, Rosemary and Salamander and Luhan fruit plant or extract thereof, Sage and Salamander and Luhan fruit plant or its Extracts, Melissa and Salamander and Rakan fruit plants or extracts thereof, Thyme and Salamander and Rahan fruit plants or extracts thereof, Rosemary and Salamander and Collae plants or extracts thereof, Sage and Salamander and Collae Plants or extracts thereof, rosemary and sansho As well as plant or an extract thereof Lo Han Guo.

  The intraoral composition of the present invention can further contain tocotrienol and / or laccase, and can give a higher bad breath suppressing effect by blending these components. In this case, the amount of tocotrienol is preferably 0.001 to 10%, particularly 0.01 to 5% in the composition, and the amount of laccase is 0.0005 to 1%, particularly 0, in the composition. 0.001 to 0.5% is preferable.

  In the oral cavity composition of the present invention, menthol or a derivative thereof can be blended as the component (D) in addition to the above components, and a sweetener can be blended as the component (E) and a fragrance can be blended as the component (F). it can.

  In this case, the menthol or menthol derivative may be isolated from an essential oil such as a plant or chemically synthesized, or an essential oil such as mint oil containing menthol may be used as it is. Examples of mint oil include peppermint oil, peppermint oil, spearmint oil and the like, and one or more kinds can be used, and they may be used in combination with the above-mentioned isolated or synthetic menthol. Examples of the menthol derivative include l-isopulegol, l-methylglyceryl ether, p-menthane-3,8-diol, etc. Among them, l-isopulegol is preferable. The blending amount is 0.0001 to 50% of the entire composition, preferably 0.0005 to 20%, more preferably 0.001 to 10%. If the amount is less than this, a satisfactory effect is not exhibited. If it exceeds 50%, the stability or flavor of the composition may be impaired.

  Examples of the sweetener include sucrose, fructose, glucose, lactose, reduced maltose water candy, powdered reduced maltose water candy, glucose fructose liquid sugar, fructose glucose liquid sugar, honey, sorbitol, maltitol, mannitol, xylitol, erythritol. It preferably contains at least one selected from aspartame, saccharin and sodium saccharin, and more preferably contains at least one selected from sucrose, fructose, powdered reduced maltose water candy, xylitol and erythritol. Of these, sucrose is particularly preferable in terms of flavor, and sucrose having a reducing sugar content of less than 0.05% is most preferable in terms of particularly improved flavor. . The blending amount of the sweetening agent is preferably 0.001 to 50%, particularly 0.01 to 20% of the entire composition.

  As said fragrance | flavor, fragrance | flavors other than the menthol and menthol derivative of (D) component, especially the fragrance | flavor component normally used in oral product field | areas, such as a toothpaste, a mouthwash, a mouth freshener, and a chewing gum, can be selected suitably and can be used. . For example, natural flavors include mastic oil, parsley oil, anise oil, eucalyptus oil, winter green oil, cassia oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, laurel oil, Examples include camomile oil, caraway oil, bay oil, lemongrass oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint, absolute rose, and orange flower.

  Single flavors include carvone, anethole, methyl salicylate, cinnamic aldehyde, linalool, linalyl acetate, limonene, menthone, menthyl acetate, pinene, octyl aldehyde, citral, pregon, carbyl acetate, anisaldehyde, ethyl acetate, Ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl anthranilate, vanillin, undecalactone, hexanal, ethinone alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural trimethyl Examples include pyrazine, ethyl lactate, and ethyl thioacetate. Examples of blended fragrances including single fragrances and / or natural fragrances include strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, fruit mix flavor and the like. Moreover, the form of a fragrance | flavor may be an essential oil, an extract, a solid substance, or the powder which spray-dried these.

  The blending amount is preferably 0.0001 to 50% of the entire composition, particularly preferably 0.001 to 10%. If less than this, a satisfactory effect may not be exhibited. The flavor may be impaired.

The oral composition of the present invention includes dentifrices (toothpaste, powder toothpaste, water toothpaste, mouthwash, etc.), mouthwash, gum massage cream, oral ointment, gargle tablet, troche, film agent, chewable tablet, Can be prepared as candy, chewing gum, chocolate agent, gel agent, etc., according to its type and dosage form, other known additives can be blended as optional components in addition to the above essential components, and prepared according to conventional methods possible, the present invention shall be the films, particularly intraoral adhesive preparation adhered to the mucosa. That is, this composition is suitable as an intraoral patch because it is less irritating to drugs and the bitterness is suppressed even if it is applied to the oral mucosa for a certain period of time.

  In the case of a film preparation such as an intraoral patch, a film having the ability to form a film and edible is used, and a synthetic polymer substance such as polyvinyl pyrrolidone (hereinafter referred to as “PVP”), carboxyvinyl polymer (Hereinafter referred to as “CVP”), polyvinyl alcohol (hereinafter referred to as “PVA”) and the like; cellulose derivatives such as hydroxypropylmethylcellulose (hereinafter referred to as “HPMC”), hydroxypropylcellulose (hereinafter referred to as “HPC”), Hydroxyethyl cellulose (hereinafter referred to as “HEC”), methyl cellulose (hereinafter referred to as “MC”), ethyl cellulose (hereinafter referred to as “EC”), etc .; high molecular substances obtained from natural products such as sodium alginate, dextran, casein, pullulan , Pectin, gum arabic, karaya gum, denp And the like. Particularly preferred are PVP, HPC, starch, locust bean gum, carrageenan and gellan gum. These substances can be used alone or in combination of two or more. The total amount is 20 to 90%, preferably 25 to 80% of the dry mass of the film. Furthermore, a plasticizer can be blended in addition to the polymer substance. As the plasticizer, a compound that is compatible with the above-described polymer substance and softens it is used. For example, glycerin, diglycerin, triglycerin, polyglycerin, sorbitol, maltitol, xylitol, polyethylene glycol, propylene glycol, Examples include butylene glycol, hexylene glycol, pentylene glycol, polyoxyethylene polyoxypropylene glycol, and acetylethanolamine, with propylene glycol, glycerin, sorbitol, xylitol, and polyethylene glycol being particularly preferable. The addition amount of the plasticizer is 1 to 30% of the dry mass of the film, and more preferably 5 to 20%.

  In addition to the above components, appropriate components can be further blended depending on the form of the composition. For example, as the nonionic surfactant, a fatty acid ester of sugar or sugar alcohol, each having a fatty acid residue having 12 to 18 carbon atoms and an average degree of esterification of 1.1 to 2.5, preferably 1. 2 to 1.9 can be used. Examples of the fatty acid ester of the sugar or sugar alcohol include sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, maltotriitol fatty acid ester, maltotetritol fatty acid ester, maltopentytitol fatty acid ester, maltohexai Examples include tall fatty acid esters, maltoheptitol fatty acid esters, sorbitan fatty acid esters, lactose fatty acid esters, and lactitol fatty acid esters. Other nonionic surfactants include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester. Fatty acid monoglycerides, polyoxyethylene higher alcohol ethers, polyoxyethylene polyoxypropylene fatty acid esters and the like can also be used.

  Examples of the anionic surfactant include sodium-N-methyl-N-palmitoyl tauride, sodium-N-lauroyl-β-alaninate, sodium lauroyl sarcosine, sodium-N-long chain acyl basic amino acid, and the like. . Furthermore, as the amphoteric surfactant, for example, 2-alkyl-N-carboxymethyl-N-hydroxylethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, lauryldimethylaminoacetic acid betaine, and the like are used.

  These surfactants may be used alone or in combination of two or more. The compounding quantity of surfactant is 0.01 to 5% of the whole composition normally, Preferably it is 0.05 to 3%.

  In the oral cavity composition of the present invention, for example, in the case of a paste-like composition such as an ointment, an anionic cellulose derivative such as carrageenan, sodium carboxymethylcellulose, sodium carboxymethylhydroxylethylcellulose, sodium alginate, etc. Alkali metal alginate, propylene glycol alginate ester, xanthan gum, tragacanth gum, karaya gum, gum arabic gum and other gums, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone and other synthetic binders, silica gel, aluminum silica gel, beegum, 1 type, or 2 or more types, such as inorganic binders, such as a laponite, may be mix | blended. These compounding quantities are 0.3 to 5% of the whole composition normally.

  Furthermore, in the production of paste-like and liquid oral compositions, one kind of thickener such as sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lactit, etc. Or 2 or more types may be mix | blended. These compounding quantities are 10 to 70% of the whole composition normally.

  In the case of dentifrice, dicalcium phosphate dihydrate and anhydride, primary calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, anhydrous silicic acid, silica gel, aluminum silicate Insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin and the like can be blended in one or more, and the blending amount is usually In the case of a toothpaste, it is 5 to 60%.

  Medicinal ingredients include cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decalinium chloride, phenolic compounds such as triclosan, hinokitiol, biozol, dextranase, mutanase, lysozyme, amylase Enzymes such as protease, lytic enzyme, superoxide dismutase, vitamins such as vitamin C, alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, sodium fluoride, stannous fluoride Such as fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, azulene, biphenyl Borol, glycerophosphate, chlorophyll, sodium chloride, water-soluble inorganic phosphate compounds, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene・ Contains one or more known active ingredients such as maleic anhydride copolymer, epidihydrocholesterin, trichlorocarbanide, zinc citrate, sugarcane, duckweed, chamomile, clove, ogon, safflower extract Can do. These substances can be used alone or in combination of two or more. When blending these medicinal ingredients, the blending amount is 0.005 to 30%, preferably 0.01 to 20% of the entire composition.

  In addition, general pharmaceutical compositions include antibacterial substances, antihistamines, anti-inflammatory agents, antiviral agents, antifungal biological agents, anesthetics, immunosuppressants, antimetabolites, anthelmintics, amoeba eradication agents, analgesics, anti Arthritis agent, antipsychotic agent, antihypertensive agent, muscle relaxant and the like, more specifically, fosexitin, N-formamidoylchenamicin, tetracycline, chloramphenicol, neomycin, carbenicillin, colistin, penicillin G, Polymyxin B, vancomycin, sehazoline, cephaloridine, tibrolihamycin, gramicidin, bacitracin, sulfonamide, gentamicin, kanamycin, amikacin, sisomicin, tobramycin, nalidixic acid, norfloxacin, fludaranin, nitrofurazone, pyrilamine, chloroamine Phenylamine, tetrahydrazoline, antazoline, cortisone, hydrocortisone, cortisone acetate, betamethasone, dexamethasone, dexamethasone sodium phosphate, prednisone, methylprednisolone, medrison, fluorometholone, fluocortron, prednisolone, sodium prednisolone phosphate, triamcinolone, indomethacin , Sulindac, ecothiophene, pilocarpine, physostigmine salicylate, diisopropylfluorophosphate, epinephrine, dipivoryl epinephrine, neostigmine, ecothiopate iodide, demepotassium bromide, carbachol, methacholine, betanecol, atropine, homatropine, scopolamine, hydroxyamphetamine, hydroxyamphetamine , Cocaine, toro Camide, phenylephrine, cyclopentrate, oxyphenonium, eucatropine, timolol, glycerol, urea, ivermectin, pyrimethamine, trisulfapyrimidine, clindamycin, acyclovir, 5-iodo-2-deoxyuridine, adenosine arabinoside, tri Fluorothymidine, interferon, acetazolamide, dichlorofenamide, amphotericin B, nystatin, flucytosine, natamycin, miconazole, etidocaine cocaine, benoxinate, dibucaine hydrochloride, dichronin hydrochloride, naepine, phenacine hydrochloride, piperocaine, proparacaine hydrochloride, hydrochloric acid Tetracaine, hexylcaine, bupivacaine, lidocaine, mepivacaine, rose bengal, adrenaline, hydroxyan Examples include fetamine, pilocarpine, chymotrypsin, EDTA, deferoxamine, methotrexate, cyclophosphamide, azathioprine, insulin, lidocaine and the like. These substances can be used alone or in combination of two or more. When these components are blended, the blending amount is 0.005 to 30%, preferably 0.01 to 20% of the entire composition.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Examples 1-7, Comparative Examples 1-3]
According to the composition shown in Table 1, ingredients such as plant ethanol extract or plant powder, hydroxypropylcellulose, polyethylene glycol, water and the like are added to an appropriate amount of ethanol and dissolved by stirring, and this is spread and dried on a polyester release film, A film about 300 μm thick was produced. The obtained film was cut into a round shape having a diameter of 14 mm to obtain an intraoral patch.
About the prepared sample, bad breath suppression evaluation was performed in the following procedure. The results are shown in Table 1.
Method: For 20 men and women with strong bad breath, 1 liter of exhaled breath was collected in a Tedlar bag before applying the sample, 10 minutes after applying, and 60 minutes after the product disappeared from the mouth, and the intensity of bad breath was evaluated. Evaluated by the person. Evaluation was evaluated in the following four stages in comparison with the state before pasting, and a value of ○ or higher was judged as a good level.
◎: Suppressed very much ○: Suppressed ×: Not changed <Usage (taste)>
Twenty men and women evaluated the feeling of use at the time of sticking.
◎: No bitterness ○: Some bitterness ×: Bitterness

[Example 8 ] Oral patch 1-menthol 5.0%
Pullulan 52.2
Xanthan gum down 5.9
Sorbit 8.4
Concentrated glycerin 9.0
Propylene glycol 2.7
Decaglyceryl monostearate 1.0
Acesulfame potassium 0.24
Sucralose 0.16
Aspartame 2.0
Rosemary water extract (Toyotama Fragrance Co., Ltd.) 1.0
Salam ethanol extract (Kyoto Food Research Co., Ltd.) 0.5
Rahan fruit extract 1.0
Parsley oil 0.05
Water remaining
Total 100.0

About Example 8 , this was applied by the conventional method, and as a result of implementing the same bad breath test as Examples 1-7, as shown in Table 2, the outstanding bad breath suppression effect was recognized.

[Example 9 ] Oral patch Pullulan 2.0%
Hydroxypropylcellulose 28.0
Hydroxypropyl methylcellulose 25.0
Polyvinyl alcohol 1.0
Xanthan gum 6.0
D-sorbitol 8.0
Concentrated glycerin 10.0
Aspartame 0.05
Sorbitan monostearate 0.5
Cetylpyridinium chloride 2.0
Dipotassium glycyrrhizinate 3.5
Ethanol 5.0
Rosemary water extract (made by Toyoda Fragrance Co., Ltd.) 0.02
Salamander ethanol extract (Kyoto Food Research Institute Co., Ltd.) 0.3
l-Menthol 1.0
Water remaining
Total 100.0

Claims (5)

(A) A bad breath consisting of a plant of Lamiaceae selected from rosemary, sage, thyme, marjoram, melissa, perilla, oregano, basil, naginata, or extract thereof; and (B) a salamander seed or extract thereof. An intraoral patch for suppressing bad breath, comprising an inhibitor . The oral patch for suppressing bad breath according to claim 1 , wherein the content of the component (A) is 0.01 to 10% by mass and the content of the component (B) is 0.01 to 10% by mass. Furthermore, the bad breath of Claim 1 or 2 which mix | blended 1 type (s) or 2 or more types chosen from the plant which consists of Coriaceae cola, its extract, the plant which consists of Cucurbitaceae rakanka, and its extract as (C) component Intraoral patch for suppression. Furthermore, intraoral patch for halitosisinhibition according to any one of claims 1 to 3 was blended tocotrienol and / or laccase. Further, (D) as a component, menthol or buccal patch for halitosisinhibition according to any one of claims 1 to 4 formulated with a derivative thereof.