JP7264049B2 - oral composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an oral cavity composition that is excellent in reducing the sticky feeling in the oral cavity, which is a cause of bad breath, and has an excellent effect of imparting a refreshing feeling, and is suitable for suppressing bad breath.

Conventionally, it has been known that sterilization of halitosis-causing bacteria with bactericides, and use of active ingredients such as deodorants and inhibitors of halitosis-causing substances are effective in suppressing halitosis. have been proposed. For example, extracts from plants such as Labiatae and Rutaceae are known as bad breath suppressing ingredients, and other oral compositions containing plant extracts as active ingredients for preventing bad breath have been proposed. (Patent Documents 1 to 3: JP-A-2005-289918, JP-A-5776364, JP-A-2016-112634). Oral compositions containing these plant extracts are effective in reducing halitosis-causing components, such as volatile sulfur and methyl mercaptan, and have a halitosis-preventing effect on exhaled breath (for humans).

However, in recent years, even though there is no bad breath (exhalation halitosis) that can be detected by others, people may feel that they have bad breath due to discomfort in the oral cavity, and develop interpersonal halitosis. There are an increasing number of cases where people are worried about bad breath. For this reason, it is thought that if such anxiety about bad breath can be eliminated, a satisfactory effect of suppressing bad breath can be obtained.

JP 2005-289918 A Japanese Patent No. 5776364 JP 2016-112634 A JP 2014-125440 A JP 2015-182983 A JP 2016-102076 A Japanese translation of PCT publication No. 2014-507440 Japanese Patent Publication No. 2012-508741 Japanese Patent Publication No. 2011-520925 JP 2013-112634 A

However, conventional compositions for the oral cavity intended to suppress halitosis cannot provide a sufficient feeling of effectiveness capable of relieving anxiety about halitosis as described above, and improvements have been desired.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral cavity composition that has an excellent effect of improving stickiness in the oral cavity and imparting an excellent refreshing feeling.

In order to achieve the above object, the present inventors have found an effect of suppressing bad breath by improving discomfort such as a sticky feeling in the oral cavity and a lack of refreshing feeling, which are considered to be the main causes of anxiety about bad breath. We considered that it would be effective to enhance the sense of urgency, and focused on these points and proceeded with further studies. As a result, by selecting specific components among plant extracts and cooling sensation agents, and using both components in specific amounts and ratios in combination, the feeling of stickiness in the oral cavity can be improved, and the feeling of stickiness in the oral cavity can be improved. It was found that an excellent action and effect of providing a refreshing feeling can be obtained. When a combination system of both components is blended into an oral composition, the effect of improving the sticky feeling in the oral cavity is excellent, and the effect of imparting a persistent and excellent refreshing feeling as described above is exhibited. It is possible to suppress internal irritation and provide a good feeling of use, thereby increasing the effect of suppressing bad breath, and finding that it is possible to eliminate not only interpersonal bad breath but also anxiety about bad breath. I came up with the invention.
That is, in the present invention, (A) 0.00001 to 0.05% by mass of a plant extract as a pure extract component, and (B) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide ( B-1) and one or more selected from N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-2) in an amount of 0.00001 to 0.01% by mass. By containing (A) / (B) in a mass ratio of 0.02 to 100, the effect of improving the sticky feeling in the oral cavity is excellent, and the effect of imparting an excellent refreshing feeling is obtained. A good oral composition can be provided.

More specifically, as shown in Comparative Examples below, the single use of component (A) or component (B) had little effect of improving stickiness in the oral cavity and imparting refreshing feeling (Comparative Example 1). ~15). Therefore, from this result, it was not thought that the combined use of both would improve both functions and effects. When combined, both components act synergistically within a specific range of the blending amount of both and the specific range of the mass ratio of (A) / (B), suppressing irritation in the oral cavity and improving the sticky feeling. The effect of imparting a refreshing feeling was enhanced, and a particularly remarkable action and effect were exhibited. Such effects of the present invention are peculiar to the combination of components (A) and (B), and instead of component (B), menthol, peppermint oil, or When monomenthyl succinate is used in combination with component (A), the results are inferior (Comparative Examples 16 to 18), and when N-substituted-p-menthane-carboxamides other than component (B) are used in combination with component (A), inferior.
Patent Documents 4 to 9 (JP 2014-125440, JP 2015-182983, JP 2016-102076, JP 2014-507440, JP 2012-508741, JP 2011- 520925) is an oral composition in which coolness and freshness are improved by N-substituted-p-menthane-carboxamide as a cooling or refreshing agent; Disclosed are oral compositions containing p-menthane-3,8-diol isomer mixtures. On the other hand, the present invention aims to improve the sticky feeling in the oral cavity and impart a refreshing feeling by using the components (A) and (B) in combination, and the technical idea thereof cannot be predicted from Patent Documents 4 to 10.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) a plant extract of 0.00001 to 0.05% by mass as a pure extract content;
(B) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), and having a mass ratio of (A)/(B) of 0.02 to 100.
[2]
(A) Plant extracts include rosemary, scutellaria root, carrot, sage, licorice, angelica root, persimmon, cattle bean, olive, tea, yellowfin tuna, kuromoji, Japanese pepper, thyme, white birch, peony, red beetle, asenyak, turmeric, clove, stevia , soapberry, marjoram, melissa, perilla, laurel, eucalyptus, cola, monk fruit, camellia, clove, allspice, suou, chikon, rhubarb, forsythia, chimp, cinnamon bark, oregano, basil, naginata koji, botanpi and seitakamyrobalan The oral composition according to [1], which is an extract of one or more plants.
[3]
(A) The oral cavity use according to [2], wherein the plant extract is one or more plant extracts selected from rosemary, scutellaria root, carrot, sage, licorice, angelica root, persimmon, jack bean, olive, tea and yellowfin tuna. Composition.
[4]
Furthermore, (C) one or more selected from menthyl monosuccinate, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide and menthyl lactate is contained in an amount of 0.0001 to 0.01% by mass [1 ] to the oral cavity composition according to any one of [3].
[5]
The oral composition according to any one of [1] to [4], which is a dentifrice or mouthwash.
[6]
The oral cavity composition according to [5], which is a dentifrice and further contains (D) 8 to 70% by mass of an abrasive.

ADVANTAGE OF THE INVENTION According to this invention, the oral-cavity composition which is excellent in the effect of improving the sticky feeling in the oral cavity which causes bad breath, has the effect of giving an excellent refreshing feeling, and has a good feeling in use can be provided. The composition for oral cavity of the present invention has a high feeling of suppressing bad breath, and can be suitably used for suppressing bad breath.

The present invention will be described in further detail below. The oral composition of the present invention comprises (A) a plant extract, and (B) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N-(2-( 2-Pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-2) in specific amounts and in specific ratios.

(A) The plant extract is a plant extract, and when used in combination with the component (B), it has the effect of reducing stickiness in the oral cavity.
Plants used as raw materials for the extract include rosemary, Scutellaria root, carrot, sage, licorice, Angelica keiskei, persimmon (especially tannin of persimmon), jack bean, olive (especially olive leaf), tea, and yellowfin tuna (especially bark). Phellodendron bark), kuromoji, Japanese pepper, thyme, white birch, peony, red oak, ashen yak, turmeric, clove, stevia, soapberry, marjoram, melissa, perilla, laurel, eucalyptus, cola, monk fruit, camellia, clove, allspice, suou, chikon , rhubarb, forsythia, chimp, cinnamon bark, oregano, basil, naginatakoju, botanpi, seitakamyrobalan and the like. Among these, rosemary, scutellaria root, carrot, sage, licorice, angelica root, persimmon, natamame, olive, tea, yellowfin tuna, kuromoji, and Japanese pepper are preferable, and more preferably rosemary, scutellaria root, carrot, sage, licorice, angelica root, They are persimmon, jack bean, olive, tea and yellowfin tuna, more preferably rosemary, scutellaria root, carrot, sage and licorice.

A well-known method can be adopted as a method for extracting the plant extract, and the extraction can be performed under normal extraction conditions.
Specifically, a plant extract is obtained by extracting a raw material plant, especially a powder obtained by pulverizing leaves and stems, using a polar solvent, a nonpolar solvent, or a mixed solvent of a polar solvent and a nonpolar solvent. Obtainable. Examples of the extraction solvent include polar solvents such as water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol, butylene glycol, and glycerin, or n-hexane, petroleum ether, ligroin, and cyclohexane. , carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, benzene, or a mixed solvent thereof.
Preferred extraction solvents are water, lower monohydric alcohols having 1 to 5 carbon atoms (especially methanol, ethanol, propanol, isopropanol, etc.), glycols (especially propylene glycol, butylene glycol, etc.), or mixed solvents thereof. The mixed solvent preferably contains water and a lower monohydric alcohol or glycol at a mixing ratio of 10:90 to 90:10 (mass ratio). The extraction solvent may be water only.
A plant extract obtained by extracting an extraction residue using the above-mentioned solvent can also be used.
A commercial item can also be used for such a (A) plant extract. Specifically, commercially available products such as Maruzen Pharmaceutical Co., Ltd. and Yamada Yaken Co., Ltd. can be used.

(A) The blending amount of the plant extract is 0.00001 to 0.05 % (% by mass, the same shall apply hereinafter), preferably 0.0001 to 0.005, of the entire composition as a pure extract content excluding the extraction solvent. %, more preferably 0.0002 to 0.005%. If the blending amount is less than 0.00001%, the effect of improving stickiness is inferior. Exceeding 0.05% is too irritating.

Component (B) is N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5- It is selected from methylcyclohexanecarboxamides (B-2), preferably N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-1). In addition, as the component (B), the component (B-1) or the component (B-2) may be used. good too.

The blending amount of component (B) is 0.00001 to 0.01%, preferably 0.00003 to 0.005%, of the total composition. If it is less than 0.00001%, the effect of improving the sticky feeling and the effect of imparting a refreshing feeling are inferior. If it exceeds 0.01%, the stimulation may be too strong and the aftertaste may be bad.
The blending amounts of the components (B-1) and (B-2) can be set within the range of the blending amount of the component (B).

In the present invention, (A)/(B), which indicates the mixing ratio of component (A) and component (B), is 0.02 to 100, preferably 0.05 to 20, more preferably 0.05 to 20 as a mass ratio. 0.2 to 5. Within this range, both the effect of improving stickiness and the effect of imparting refreshing feeling are excellent, and stimulation is satisfactorily suppressed. If it is less than 0.02, the effect of imparting a refreshing feeling does not last sufficiently, and the stimulation becomes strong. If it exceeds 100, the stimulus becomes stronger.

In the present invention, it is preferable to blend one or more selected from (C) menthyl monosuccinate, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide and menthyl lactate. When the (A) and (B) components are combined with the (C) component, the effect of improving stickiness is further enhanced.
Component (C) is preferably menthyl monosuccinate, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide, and more preferably menthyl monosuccinate.

The blending amount of component (C) is preferably 0.0001 to 0.01%, more preferably 0.0003 to 0.005%, based on the total composition. Within this range, the effect of improving stickiness is further improved. If it exceeds 0.01%, the stimulation may become strong and the aftertaste may become bad.

The oral composition of the present invention is prepared in the form of solid, liquid, liquid, paste, gel, etc., and can be used in dentifrices such as toothpaste, liquid dentifrice, liquid dentifrice, wet dentifrice, mouthwash, and mouth freshener. Although various formulations such as agents are possible, dentifrices or mouthwashes, particularly dentifrices, are particularly preferable, and toothpastes containing abrasives are preferable. As for the production method, a conventional method can be adopted depending on the dosage form.
Furthermore, in the present invention, in addition to the above-mentioned components, known ingredients can be blended as necessary depending on the purpose of the composition, the dosage form, etc., as long as the effects of the present invention are not impaired. For example, in the case of a toothpaste, abrasives, binders, wetting agents, surfactants, sweeteners, preservatives, pH adjusters, perfumes, medicinal ingredients and the like can be used. In the case of a mouthwash, humectants, surfactants, sweeteners, preservatives, pH adjusters, fragrances, medicinal ingredients and the like can be mentioned.

Abrasives include calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, tricalcium phosphate, and calcium pyrophosphate; precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, etc. calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, magnesium tertiary phosphate, magnesium carbonate, calcium sulfate, bentonite, and hydroxyapatite; More than seeds can be blended. Among these, silica-based abrasives and calcium carbonate-based abrasives mainly composed of silicates such as precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, and especially silica-based abrasives such as precipitated silica, etc. Abrasives are preferred.

The abrasive, especially precipitated silica, is preferably abrasive particles having a particle size of 1-40 μm, and more preferably a BET specific surface area of 80-250 square meters per gram. The particle size is a value measured by a particle size distribution analyzer (Microtrac particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium: water).
As such silica-based abrasives, commercially available products can be used. Co., Ltd. zirconosilicate, aluminosilicate and the like.
The compounding amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the total composition.

Also, the abrasive may be in the form of granules, and granules can be blended as a component having abrasive properties. Granules are particles obtained by forming water-insoluble powder into granules, and may be granules obtained by crushing silica gel or granules using a binder for granulation.
As the abrasive, the abrasive particles having a particle size of 1 to 40 μm and the granules described above may be used in combination.

Binders include xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol. , Veegum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate. These can be used alone or in combination of two or more. The content of the binder is preferably 0.8 to 5%, particularly 1 to 3%, of the total composition in the case of an organic binder, and 0.5 to 10% of the total composition in the case of an inorganic binder. %, especially 1 to 8%.

Wetting agents include sugar alcohols such as sorbitol and xylite, and polyhydric alcohols such as propylene glycol and glycerin. The amount is usually 5-50%, especially 20-45% of the total composition.

Surfactants include anionic surfactants, nonionic surfactants, and amphoteric surfactants. Anionic surfactants are particularly preferred.
Examples of anionic surfactants include alkyl sulfates, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetates, N-acyl taurates such as N-methyl-N-acyl taurates, Examples include acyl amino acid salts such as acyl sarcosine salts and N-acyl-L-glutamates. These can be used alone or in combination of two or more. Among them, anionic surfactants containing a sulfonic acid group are preferable, and alkyl sulfates and α-olefin sulfonates are more preferable in terms of foamability and foam quality. Examples of the salt include sodium salt, potassium salt, ammonium salt and the like, with sodium salt being particularly preferred.
The alkyl sulfate preferably has 12 to 14 carbon atoms in the alkyl group, and specific examples of the alkyl sulfate include sodium lauryl sulfate and sodium myristoyl sulfate.

As the α-olefin sulfonate, an alkali metal salt such as sodium or potassium of an α-olefin sulfonate having 14 to 16 carbon atoms can be used. A salt (common name: sodium tetradecene sulfonate) is preferred.
The amount of surfactants, especially anionic surfactants, is preferably 0.6 to 2.5%, more preferably 1 to 2.5%, of the total composition, for example, in the case of dentifrices. For mouthwashes, it is preferably 0-1.0%, especially 0-0.3% of the total composition.

Sweeteners include sodium saccharin, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like. Preservatives include paraoxybenzoic acid esters, sodium benzoate and the like.
Examples of pH adjusters include organic acids such as citric acid and lactic acid, salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

Flavoring agents include known oral fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyllinalool, vanillin, thymol, spearmint oil, Peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil and the like.

Medicinal ingredients include enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, azulene, glycyrrhizinate, and glycyrrhizinate; Cell activators; Bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride; Water-soluble copper compounds such as copper chlorophyll and copper gluconate; Anticalculus agents; Blood circulation promoters such as vitamin E ; Amino acids such as alanine, glycine, proline and the like can be added. In addition, the compounding amount of the medicinal component can be an effective amount within a range that does not impair the effects of the present invention.

Furthermore, as optional ingredients, inorganic compounds such as mica titanium, titanium oxide, and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, and glucomannan; polyvinyl acetate, and acrylic resins. , synthetic polymer compounds such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, and natural rubber can be blended as long as the effects of the present invention are not impaired.
Purified water is generally used as the solvent. A lower monohydric alcohol having 1 to 3 carbon atoms such as ethanol may also be added. The blending amount of the lower monohydric alcohol is preferably 0 to 10% of the total composition.

EXAMPLES The present invention will be specifically described below by showing Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
A dentifrice composition (toothpaste) or a mouthwash having the composition shown in Tables 1 to 6 was prepared by a conventional method and placed in a conventional oral formulation container (toothpaste: laminated tube, mouthwash: bottle). . These were used as samples and evaluated by the methods described below. The results are also shown in Tables 1-6. The numerical value of the blending amount of component (A) in the table is the pure amount of the extract excluding the extraction solvent.

<Raw materials used>
(A) Component <<A1: Rosemary Extract>>
Product name: Rosemary extract-J, Extraction solvent: 50% ethanol, Part used: Leaves Manufacturer: Maruzen Pharmaceutical Co., Ltd.
《A2: Scutellaria root extract》
Product name: Scutellaria root extract-J, Extraction solvent: 50% ethanol, Part used: Root manufacturer: Maruzen Pharmaceutical Co., Ltd.
<<A3: carrot extract>>
Product name: Carrot extract, Extraction solvent: 50% ethanol, Part used: Root Manufacturer: Maruzen Pharmaceutical Co., Ltd.
《A4: Sage Extract》
Product name: Salvia extract, Extraction solvent: 50% ethanol, Part used: Leaves Manufacturer: Maruzen Pharmaceutical Co., Ltd.
《A5: Glycyrrhiza Extract》
Product name: Glycyrrhiza extract, Extraction solvent: 50% ethanol, Part used: Root Manufacturer: Maruzen Pharmaceutical Co., Ltd.
《A6: Jack Bean Extract》
Product name: AOF Jack Bean Extract-HBG, Extraction solvent: 50% 1,3-butylene glycol, Part used: Seed manufacturer: Yamada Yakuen Co., Ltd. <<A7: Persimmon tannin extract>>
Product Name: Pancil BA-200E-1, Extraction Solvent: Water, Part Used: Fruit Maker: Release Science Industry <<A8: Touki Extract>>
Product name: Angelica keiskei extract-JC, Extraction solvent: 50% ethanol, Part used: Root Manufacturer: Maruzen Pharmaceutical Co., Ltd.
<<A9: Olive Leaf Extract>>
Product name: Olive extract-BG, Extraction solvent: 50% butylene glycol, Part used: Leaves Manufacturer: Maruzen Pharmaceutical Co., Ltd.

(B) Component <<B1: N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide>>
Product name: Evercool G-180, manufacturer: Givaudan Japan <<B2: N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide>>
Product name: Evercool G-190, Manufacturer: Givaudan Japan

(C) Component <<C1: menthyl monosuccinate>>
Product name: Fiscool, manufacturer: Vemanfis <<C2: N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide>>
Product name: WS-5, Manufacturer: Symrise <<C3: Menthyl lactate>>
Trade name: Frescolat ML, manufacturer: Symrise Inc. Fragrance compositions A to P shown in Tables 7 to 15 below were used as fragrances.

<Evaluation method>
It was evaluated by 4 subjects.
1 g of the sample dentifrice composition was placed on a toothbrush (clinica advantage toothbrush, 4-row compact normal, manufactured by Lion Co., Ltd.), and after brushing the teeth for 3 minutes, the oral cavity was rinsed once with 10 mL of water. When the sample was a mouthwash, 10 mL was put in the mouth, washed for 30 seconds, and then discharged. Stickiness in the oral cavity after use, clean feeling in the oral cavity after 60 minutes of use, and oral irritation (absence of irritation in the oral cavity immediately after use) were evaluated according to the following rating criteria. , the average score of 4 people was obtained and evaluated according to the following evaluation criteria.

<Sticky feeling in the oral cavity>
Rating criteria 5: Not felt at all 4: Not felt much 3: Neither felt nor felt 2: Somewhat felt 1: Very felt Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

<Clean feeling in the oral cavity>
Rating criteria 5: Strongly felt 4: Fairly felt 3: Neither felt 2: Slightly felted 1: Not felt at all Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

<Oral stimulation>
Rating criteria 5: Not felt at all 4: Not felt much 3: Neither felt nor felt 2: Somewhat felt 1: Very felt Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

A formulation example is shown below. The raw materials used are the same as above.

[Prescription Example 1] Dentifrice (A) A1: Rosemary extract 0.0002% as pure extract content
(B) B1: N-(4-cyanomethylphenyl)-2-isopropyl-5-
Methylcyclohexanecarboxamide 0.001
(C) C1: menthyl monosuccinate 0.0005
(C) C3: menthyl lactate 0.0003
(D) abrasive silica 15
Sorbit solution (70%) 30
Propylene glycol 4
Thickening silica 4
Xanthan gum 1.5
Sodium lauryl sulfate 1.5
Sodium fluoride 0.2
Saccharin sodium 0.2
Perfume 1
water
Total 100%
(A)/(B) = 0.2

[Prescription Example 2] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N-(2-(2-pyridinyl)ethyl)-2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: menthyl monosuccinate 0.0005
(C) C3: menthyl lactate 0.0003
Ethanol 2.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Perfume 1
water
Total 100%
(A)/(B) = 0.04

[Prescription Example 3] Mouthwash (A) A1: Rosemary extract 0.0002% as pure extract
(B) B2: N-(2-(2-pyridinyl)ethyl)-2-isopropyl-
5-methylcyclohexanecarboxamide 0.005
(C) C1: menthyl monosuccinate 0.0005
(C) C3: menthyl lactate 0.0003
Propylene glycol 3.0
Menthol 0.06
Citric acid 0.05
Sodium citrate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.5
Cetylpyridinium chloride 0.05
Methyl paraoxybenzoate 0.25
Perfume 1
water
Total 100%
(A)/(B) = 0.04

Claims (5)

(A) Water of one or more plants selected from rosemary, scutellaria root, carrot, sage, licorice, angelica root, persimmon, jack bean and olive, lower monohydric alcohol having 1 to 5 carbon atoms, glycol, or a mixed solvent extraction thereof 0.00001 to 0.05% by mass of the extract as a pure extract content,
(B) N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide (B-1) and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing 0.00001 to 0.01% by mass of one or more selected from (B-2), and having a mass ratio of (A)/(B) of 0.02 to 100. 2. The oral composition according to claim 1 , wherein the plant is selected from rosemary, scutellaria root, carrot, sage and licorice. Further, (C) one or more selected from menthyl monosuccinate, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide and menthyl lactate in an amount of 0.0001 to 0.01% by mass. 3. The oral composition according to 1 or 2 . The oral composition according to any one of claims 1 to 3 , which is a dentifrice or mouthwash. 5. The oral composition according to claim 4 , which is a dentifrice and further contains (D) an abrasive in an amount of 8 to 70% by mass.