JP2022046221A - Dentifrice composition - Google Patents

Abstract

To provide a dentifrice composition giving a good sense of use, suppressing an irritating feeling, and giving storage stability.SOLUTION: Provided is a dentifrice composition containing (A) an acylsarcosine or salt thereof, (B) an alkali metal pyrophosphate, (C) a nonionic surfactant, and (D) a polyethylene glycol.SELECTED DRAWING: None

Description

The present invention relates to a dentifrice composition.

So far, it has been reported that acylsarcosine salts such as lauroyl sarcosine sodium (LSS) and cetylpyridinium chloride (CPC) have a bactericidal effect. For example, in Patent Document 1, a dentifrice composition containing a predetermined amount of an acyl amino acid salt, an alkyl amino acid salt, a water-soluble polyphosphate and polyethylene glycol is excellent in a stain adhesion suppressing effect, a stain removing effect, and a usability. It is stated that. In Patent Document 2, an oral composition containing N-acylamino acid or a salt thereof, pyrophosphate or a salt thereof in a predetermined ratio realizes the effect of removing protein stains, preventing the adhesion of protein stains to the tooth surface, and cleaning. It is stated that it can be done.

Japanese Unexamined Patent Publication No. 2013-112654 Japanese Unexamined Patent Publication No. 2014-12655

However, all of the conventional techniques have a problem that a feeling of irritation is likely to occur and the feeling of use is not always sufficient in terms of the actual feeling of cleaning. In addition, when an alkaline substance such as sodium pyrophosphate is added, a feeling of irritation may occur, and the pharmaceutical product gels over time, the water retention capacity decreases, liquid separation and rough skin occur, and the storage stability decreases. Sometimes.

An object of the present invention is to provide a dentifrice composition having a good feeling of use, a feeling of irritation being suppressed, and a good storage stability.

As a result of diligent studies to solve the above problems, the present inventors have a combination of acyl sarcosine and an alkali metal pyrophosphate having an effect of preventing stickiness in the oral cavity, and have a high cleaning feeling and exhibit for a long period of time. It was found that the usability was improved. Further, by combining these with a nonionic surfactant and polyethylene glycol, it is an object of the present invention to provide a dentifrice composition in which a feeling of irritation is suppressed and storage stability is good.
The present invention provides the following [1] to [7].
[1] A dentin composition containing (A) acylsarcosine or a salt thereof (B) an alkali metal pyrophosphate (C) a nonionic surfactant, and (D) polyethylene glycol.
[2] The dentifrice composition according to [1], wherein the ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.003 to 10.
[3] The dentifrice according to [1] or [2], wherein the ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) is 0.002 to 10. Composition.
[4] Any one of [1] to [3], wherein the ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is 0.02 to 30. The dentifrice composition according to.
[5] An oral anti-stickiness inhibitor containing (A) acylsarcosine or a salt thereof, and (B) an alkali metal pyrophosphate.
[6] The agent according to [5], which further contains (C) a nonionic surfactant.
[7] The agent according to [5] or [6], which further contains (D) polyethylene glycol.

According to the present invention, it is possible to provide a dentifrice composition which has an effect of preventing stickiness in the oral cavity and can be exerted for a long period of time, further suppresses irritation, and has good storage stability.

Hereinafter, the present invention will be described in detail.

[1. Toothpaste composition]
The dentifrice composition contains the components (A) and (B), preferably further contains at least one of the components (C) and (D), and more preferably contains the components (A) to (D). do.

[(A) Acylsarcosine or a salt thereof]
The component (A) is acylsarcosine or a salt thereof. By containing the component (A), the effect of removing stickiness in the oral cavity can be exhibited.

-Examples of acyl sarcosine and its salts-
The number of carbon atoms of the acyl group contained in acyl sarcosine is usually 10 to 18, preferably 10 to 16. The acyl group may be chain-like (straight chain, branched chain) or cyclic, and may be saturated or unsaturated. It is preferably chain-shaped. Examples of the acyl group include a lauroyl group, a myristoyl group, a palmitoyl group, and a stearoyl group, and a lauroyl group is preferable. When acylsarcosine is in the form of a salt, it may be any pharmacologically acceptable salt. Pharmacologically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt; arginine salt and the like. Basic amino acid salts of. Among them, an inorganic base salt is preferable, an alkali metal salt or an ammonium salt is more preferable, and a sodium salt is further preferable.

The component (A) may be one selected from acylsarcosine and a salt thereof alone or a combination of two or more thereof, but preferably contains at least lauroyl sarcosine or a salt thereof, and more preferably contains sodium lauroyl sarcosine. preferable.

-Contents of (A) component-
The content of the component (A) is usually 0.01% by mass or more, preferably 0.05% by mass or more, based on the total amount of the composition. As a result, the effect of blending the component (A) can be fully exhibited. The upper limit is usually 3% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less. As a result, the feeling of irritation can be satisfactorily suppressed. Therefore, the content of the component (A) is usually 0.01 to 3% by mass, preferably 0.01 to 1% by mass, and more preferably 0.05 to 0.5% by mass.

In the present specification, the content of each component is based on the amount of each component charged in producing the composition.

[(B) Pyrophosphate alkali metal salt]
The component (B) is an alkali metal pyrophosphate. By containing the component (B), the effect of removing stickiness in the mouth can be enhanced. Examples of the alkali metal ion forming a salt of pyrophosphate include sodium ion and potassium ion, and sodium ion is preferable.

-Contents of (B) component-
The content of the component (B) is usually 0.01% by mass or more, preferably 0.1% by mass or more, and more preferably 0.3% by mass or more with respect to the total amount of the composition. As a result, the effect of blending the component (B) can be fully exhibited. The upper limit is usually 5% by mass or less, preferably 3% by mass or less, and more preferably 1.5% by mass or less. As a result, the feeling of irritation can be satisfactorily suppressed. Therefore, the content of the component (B) is usually 0.01 to 5% by mass, preferably 0.1 to 3% by mass, and more preferably 0.3 to 1.5% by mass.

[(C) Nonionic Surfactant]
The component (C) is a nonionic surfactant. By containing the component (C), an irritation reducing effect can be obtained.

-Example of nonionic surfactant-
Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester (eg, polyoxyethylene sorbitan monostearate), alkylolamide, and polyoxy. Ethylene fatty acid ester, polyoxyethylene alkenyl ether, glycerin fatty acid ester, sucrose fatty acid ester (eg, maltose fatty acid ester), sugar alcohol fatty acid ester (eg, multitoll fatty acid ester, lactitol fatty acid ester), fatty acid diethanolamide (eg, lauryl). Acid mono or diethanolamide), polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, and the like. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 mol. The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is usually 20 to 100 mol, preferably 20 to 60 mol. The number of carbon atoms of the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The fatty acid of the polyoxyethylene sorbitan fatty acid ester usually has 16 to 18 carbon atoms, and the average number of moles of ethylene oxide added is usually 10 to 40 mol. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferable.

-Contents of (C) component-
The content of the component (C) is usually 0.01% by mass or more, preferably 0.1% by mass or more, and more preferably 0.2% by mass or more with respect to the total amount of the composition. As a result, the effect of the component (C) can be fully exerted. The upper limit is usually 10% by mass or less, preferably 5% by mass or less, and more preferably 3% by mass or less. As a result, it is possible to suppress the generation of an off-flavor peculiar to the nonionic surfactant, and it is possible to suppress the possibility that the oily flavor will be obtained and the usability will be deteriorated. Therefore, the content of the component (C) is usually 0.01 to 10% by mass, preferably 0.1 to 5% by mass, and more preferably 0.2 to 3% by mass.

[(D) Polyethylene glycol]
The component (D) is polyethylene glycol. By containing the component (D), the stability of the pharmaceutical product can be improved.

The average molecular weight of polyethylene glycol is 650 or less, preferably 600 or less, more preferably 150 to 650, and even more preferably 250 to 600. Examples of polyethylene glycol include polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 300 (average molecular weight 280 to 320), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630). However, it may be a commercially available product. In the present specification, the average molecular weight of polyethylene glycol is the average molecular weight described in the Quasi-drug Raw Material Standard 2006.

-Contents of (D) component-
The content of the component (D) is usually 0.1% by mass or more, preferably 0.5% by mass or more, and more preferably 1% by mass or more with respect to the total amount of the composition. If it is less than this, the kneaded skin may be insufficient. The upper limit is usually 10% by mass or less, preferably 5% by mass or less, and more preferably 3% by mass or less. If it exceeds this, liquid separation may occur. Therefore, the content of the component (D) is usually 0.1 to 10% by mass, preferably 0.5 to 5% by mass, and more preferably 1 to 3% by mass.

[Content ratio]
-(A) / (B)-
The ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is usually 0.001 to 20, preferably 0.003 to 10, more preferably 0.05. ~ 1. As a result, the effect of suppressing stickiness in the oral cavity is exhibited and can be sustained for a long period of time, the feeling of irritation in the oral cavity is suppressed, and the appearance such as suppression of liquid separation and good paste of kneaded skin is good even after storage. Etc., a storage stability effect can be obtained.

-(A) / (C)-
The ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) is usually 0.001 to 15, preferably 0.002 to 10, more preferably 0.05. ~ 1. As a result, the effect of suppressing stickiness in the oral cavity can be exerted and can be sustained for a long period of time, and the effect of suppressing the feeling of irritation in the oral cavity can be obtained.

-(B) / (C)-
The ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is usually 0.01 to 50, preferably 0.02 to 30, more preferably 0.3. ~ 4. As a result, the effect of suppressing stickiness in the oral cavity is exhibited and it can be sustained for a long period of time.

[Arbitrary ingredient]
The dentifrice composition may contain components other than the components (A) to (D) as long as the effects of the present invention are not impaired. Examples of other components include dentifrice compositions such as abrasives, binders, surfactants, wetting agents, sweeteners, fragrances, pH regulators, preservatives, medicinal ingredients, colorants (pigments), and solvents. Ingredients that can be incorporated into, but are not limited to these.

-Abrasive-
As the polishing agent, for example, calcium phosphate-based such as dibasic calcium phosphate dihydrate or anhydrous, first calcium phosphate, tertiary calcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, third calcium phosphate, fourth calcium phosphate, eighth calcium phosphate and the like. Compounds; Silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, titanium-binding silica, silica gel; calcium carbonate-based abrasives such as calcium carbonate (light and heavy); aluminum such as aluminum hydroxide and alumina Based-based abrasives; Magnesium-based abrasives such as magnesium carbonate and tertiary magnesium phosphate; Silica-based abrasives such as anhydrous silicic acid, zeolite, and zirconium silicate; Apatite-based abrasives such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite. Agents; calcium hydroxide; calcium sulfate, bentonite; titanium dioxide; crystalline zirconium silicates; polymethylmethacrylate; synthetic resin-based abrasives, preferably silica-based abrasives, more preferably precipitated silica, aluminosilicates, A silica-based abrasive containing a silicate as a main component, such as zirconosilicate and titanium-binding silica, more preferably precipitating silica. The precipitating silica preferably has an average particle size of 1 to 40 μm and a BET specific surface area of 80 to 250 m ² per gram. The abrasive may be one of these or a combination of two or more. The average particle size can be measured with a particle size distribution measuring device (Microtrak particle size distribution meter, dispersion medium; water) manufactured by Nikkiso Co., Ltd., and the average particle size shown in the examples is also the same.

The abrasive may be granules (for example, particles obtained by granulating water-insoluble powder which is an abrasive component into granules). The granule can be prepared by granulating the polishing component, and a binder may be used at the time of granulation. Examples of the water-insoluble powder include dicalcium phosphate, tricalcium phosphate, water-insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, and gills. Examples thereof include inorganic powders such as conosilicate and calcium sulfate, and a combination of two or more selected from these, preferably silica or zeolite. The volume average particle size (median diameter d50) of the granules is preferably 50 to 500 μm. In the present specification, the volume average particle size is a measured value by a particle size distribution measuring device (Microtrak particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium; water). The average disintegration strength of the granules is preferably 10 to 200 g / piece. In the present specification, the average disintegration strength is an automatic breaking strength measurement value of 30 granules (when one granule is compressed at a rate of 10 mm / min) by a leometer (Sun Leometer CR-200D, manufactured by Sun Kagaku Co., Ltd.). It is the average value of the load when collapsing).

As the silica granules, for example, wet gel method silica and precipitation method silica are preferably used, and the primary particle size is preferably about 3 to 15 nm, preferably 4 to 10 nm. As a method for producing a silica solaceant, for example, a mass of silica gel whose primary particle size has been grown to about 4 to 10 nm by a gel method is washed, dried, and then pulverized to obtain silica granules (average particle size is, for example, 50 to 50 to). A method of classifying into 500 μm), a method of preparing granules by spraying silica gel hydrosol in the air and gelling, and a method of precipitating to grow the primary particle size after aggregating while suppressing the growth of the primary particles (for example). Methods such as (growing until the primary particle size becomes about 4 to 10 nm) are known, and silica gel granules can be prepared by these methods. The granules may be colored. The content of the abrasive is preferably 8 to 70% by mass of the entire composition. When the abrasive is a granule, the content is preferably 0.1 to 20% by mass of the entire composition.

-Blotting agent-
Examples of the binder include cellulose-based binders (for example, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, cationized cellulose, etc.), carrageenan, xanthan gum, guagam, tragant gum, karaya gum, and arabiya gum. , Locust bean gum, sodium alginate, montmorillonite, sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, carboxyvinyl polymer (trade name: Carbopol), organic binders such as propylene glycol alginate; thickening silica, aluminum silicate, etc. Inorganic binders can be mentioned. The content of the binder is preferably 0.1 to 10% by mass, more preferably 1.4 to 8% by mass, based on the whole composition.

-Surfactant-
Examples of the surfactant include an anionic surfactant and an amphoteric surfactant.
Examples of the anionic surfactant include an alkyl sulfate, an acyl amino acid salt other than the component (A), an acyl taurine salt, an α-olefin sulfonate, a hydrogenated coconut fatty acid monoglyceride monosulfate, and a lauryl sulfoacetate. .. The alkyl group and the acyl group may be either a straight chain or a branched chain, and may be saturated or unsaturated, and the number of carbon atoms thereof is usually 10 to 20, preferably 12 to 18, particularly preferably 12 to 14. The salt can be selected from pharmacologically acceptable salts. Pharmacologically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt; arginine salt and the like. Basic amino acid salts of. Of these, inorganic base salts are preferred, alkali metal salts (eg, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of the alkyl sulfate include lauryl sulfate and myristoyl sulfate. Examples of the acyl amino acid salt include lauroyl glutamate; acyl glutamate such as myritoyl glutamate and palmitoyl glutamate; acylglycine salt such as N-lauroyl-N-methylglycine salt and cocoylglycine salt; N-lauroyl-β-. Alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, N-methyl Acylalanine salts such as -N-acylalanine salt; acylasparaginates such as lauroyl asparagate can be mentioned. Examples of the acyl taurine salt include lauroylmethyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of the α-olefin sulfonate include α-olefin sulfonates having 12 to 14 carbon atoms such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate.

The anionic surfactant preferably contains a sulfonic acid group in terms of foaming and good foam quality, and an alkyl sulfate and an α-olefin sulfonate are more preferable. The content of the anionic surfactant is preferably 0.1 to 2.5% by mass, more preferably 0.6 to 2.5% by mass, still more preferably 1 to 2.5% by mass of the entire composition. ..

Examples of the amphoteric surfactant include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (eg, lauryldimethylaminoacetic acid betaine) and fatty acid amide propyldimethylaminoacetic acid betaine (eg, cocamidopropyl betaine); N-. Fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt (eg, N-palm oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut oil fatty acid imidazolinium betaine, 2-alkyl Examples include imidazoline-type amphoteric surfactants such as -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine. Examples of the cationic surfactant include an alkylammonium salt and an alkylbenzylammonium salt. When the amphoteric tenside agent and the cationic surfactant are contained, the content of each is preferably 0.1 to 3% by mass with respect to the total amount of the composition.

-sweetener-
When the composition contains a sweetener, the feeling of use can be further improved. Examples of the sweetener include xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stebioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartame phenylalanine methyl ester and the like. Will be. The sweetener may be used alone or in combination of two or more.

-Wetting agent-
When the composition contains a wetting agent, the feeling of use can be further improved. As the wetting agent, polyhydric alcohols other than the component (C) are preferable, and for example, sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, and xylitol; glycerin; glycols such as propylene glycol and ethylene glycol; and reduced starch saccharified products. Can be mentioned. The content of the wetting agent is usually 5 to 50% by mass, preferably 20 to 45% by mass.

-Fragrance-
When the composition contains a fragrance, the feeling of use can be further improved. Examples of fragrances include peppermint oil, sparemint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamon oil, rosemary oil, majorum oil, lemon oil, orange oil, nutmeg oil, and lavender oil. Natural essential oils such as parlacles oil, laurel oil, piment oil, laurel oil, perilla oil, winter green oil; menthol, carboxylic, synamic aldehyde, anetol, 1,8-cineole, methyl salicylate, eugenol, timole, linalol, limonen, Perfume components contained in the above natural essential oils such as menthon, mentholacetate, citral, camphor, borneol, pinen, spirantol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, ethyllinalol, varnish and the like; ethyl acetate , Ethylbutyrate, isoamylacetate, hexanal, hexenal, methylanthranilate, ethylmethylphenylglycidate, benzaldehyde, vanillin, ethylvaniline, flaneol, N-ethyl-p-menthan-3-carboxamide, mentyllactate, ethyleneglycol- Fragrance components such as l-mentyl carbonate; and various blended flavors such as mint-based, fruit-based, and herb-based, which are a combination of several fragrance components and natural essential oils. The fragrance may be used alone or in combination of two or more.

-PH regulator-
When the composition contains a pH adjuster, the pH stability of the pharmaceutical product can be ensured. Examples of the pH adjuster include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid or salts thereof, and inorganic acids such as phosphoric acid (orthoric acid) or salts thereof. (For example, potassium salt, sodium salt and ammonium salt), hydroxides such as sodium hydroxide and potassium hydroxide can be mentioned. Examples of the inorganic acid salt include disodium hydrogen phosphate and sodium dihydrogen phosphate. The content of the pH adjuster is usually such that the pH of the composition after addition is 5 to 9, preferably 6 to 8.5. In the present specification, the pH value is usually a value at 25 ° C. and 3 minutes after the start of measurement, and can be measured using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

-Preservative-
When the composition contains a preservative, the antiseptic power of the pharmaceutical product can be ensured. Examples of the preservative include paraoxybenzoic acid esters (for example, methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate and the like. The preservative may be used alone or in combination of two or more.

-Medicated ingredients-
Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, timole, hinokithiol, and lysozyme chloride; Enzymes such as mutanase, amylase, protease, lytecenzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride; ε-aminocaproic acid, allantin, tranexamic acid, glycyrrhizinate (eg, glycyrrhetin dipotassium salt) ), Anti-inflammatory agents such as glycyrrhetinic acid, stearyl glycyrrhetinate, allantinchlorhydroxyaluminum, azulene, dihydrocholesterol; metal salts such as zinc, copper salt, tin salt; tooth stones such as condensed phosphate and ethanehydroxydiphosphonate. Prophylactic agents; blood flow promoters such as vitamin E (eg, tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, strontium chloride; coating agents such as hydroxyethyl cellulose dimethyldiallyl ammonium chloride; vitamin C (eg, ascorbic acid). Or its salt), lysozyme chloride, astringent such as sodium chloride; water-soluble copper compound such as copper chlorophyll, copper gluconate; tooth stone preventive agent such as zeolite, amino acids such as alanine, glycine, proline, thyme, ginger, chowji , Hamamelis and other plant extracts; caropeptide, polyvinylpyrrolidone and the like. The medicinal ingredient may be used alone or in combination of two or more. As for the content of the other active ingredients, the effective amount can be appropriately set.

-solvent-
Examples of the solvent include water, lower monohydric alcohol (eg, ethanol), and a mixed solvent thereof. The blending amount of the solvent is usually 1 to 90% by mass, preferably 15 to 80% by mass, and more preferably 20 to 60% by mass with respect to the total amount of the composition. In the case of the mixed solvent, the amount of the lower monohydric alcohol added is usually 1 to 30% by mass, preferably 1 to 20% by mass in the composition.

-Other optional ingredients-
Examples of optional components other than the above include inorganic compounds such as mica titanium, titanium oxide, and bentonite; waxes such as carnauba wax, rosin, rice wax, microcrystallin wax, honey wax, and paraffin wax; cetanol, stearyl alcohol, and the like. Higher alcohols; polyisobutylene, polybutadiene, urethane, silicon, natural rubber and the like. The content of these components can be appropriately set as long as the effect of the present invention is not impaired.

The composition of the present invention can be used as a dentifrice such as a dentifrice, a gel-like dentifrice, a liquid dentifrice, a liquid dentifrice, a dentifrice dentifrice, and a powder dentifrice, preferably a dentifrice or a gel-like dentifrice. Is.

The dosage form of the dentifrice composition can be appropriately selected depending on the usage pattern, and is not particularly limited. Examples of the dosage form include a gel form and a paste form.

[Method for producing composition]
The method for producing the dentifrice composition is not particularly limited, and can be prepared by each usual method depending on the dosage form. For example, when it is used as a dentifrice, a method of preparing a water-soluble component, mixing the other components, and defoaming (for example, reducing the pressure) as necessary can be mentioned. The obtained toothpaste can be contained in a container and made into a product. The shape and material of the container are not particularly limited, and a container used for a normal toothpaste composition can be used, and examples thereof include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

[2. Anti-stickiness agent in the oral cavity]
The stickiness inhibitor contains components (A) and (B), preferably further contains at least one of components (C) and (D), and more preferably contains components (A) to (D). do. Examples of each component, content, and content ratio are the same as those described in the previous section.
The sticky inhibitor can suppress stickiness in the oral cavity and can maintain the suppressing effect for a long period of time. The stickiness inhibitor can efficiently exert the above effect by being added to the oral composition, preferably the dentifrice composition.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition,% in the table shows mass% unless otherwise specified.

[Main raw materials used in Examples and Comparative Examples]
The main raw materials used in Examples and Comparative Examples are summarized below.
(A) Sodium lauroyl sarcosine:
NIKKOL Sarcocinate LN manufactured by Nikko Chemicals Co., Ltd.
(B) Sodium pyrophosphate:
Taihei Kagaku Sangyo Co., Ltd. (C) Polyoxyethylene (20) Hardened castor oil:
HC-20 manufactured by Nippon Emulsion Co., Ltd.
Polyoxyethylene (5) stearyl ether:
Made by Nippon Emulsion Co., Ltd., 605
(D) Polyethylene glycol:
Polyethylene glycol 400 manufactured by Sanyo Chemical Industries, Ltd.
As for other components, those conforming to the quasi-drug raw material standard 2006 were used.

Examples 1-27 and Comparative Examples 1-2 (dentifrice)
Using the above-mentioned components, toothpaste compositions having the compounding compositions (parts by mass) shown in Tables 1 to 4 were prepared according to the following preparation methods.

[Preparation method of toothpaste composition]
A water-soluble component (excluding the binder, propylene glycol, and sorbitol) was dissolved in purified water, and then a sorbitol solution and thickening silica were added and mixed to obtain a solution I. Separately, a binder was dispersed in propylene glycol to obtain a liquid II. Then, liquid II was added to the obtained liquid I and stirred to obtain liquid III. Add components other than water-soluble components such as fragrances, abrasives, and surfactants to the obtained solution III, mix at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kosakusho), and reduce the pressure (pressure 4 kPa). Defoaming was performed to obtain a toothpaste composition.

The obtained dentifrice composition was evaluated by the following procedure. The evaluation results are shown in Tables 1 to 4.

<Evaluation of stickiness and irritation in the oral cavity>
The usability was evaluated by 4 panelists (n = 4). A sample of 1 g was placed on a toothbrush (Clinica Advantage toothbrush, 4-row compact, usually manufactured by Lion), and after brushing the teeth for 3 minutes, the mouth was washed once with 10 mL of water. The presence or absence of stickiness in the mouth (stickiness in the oral cavity immediately after use and 2 hours after use) and the presence or absence of irritation in the oral cavity (stimulation in the oral cavity immediately after use) were judged by the following evaluation criteria, and 4 subjects were judged. The average score was calculated and evaluated according to the following evaluation criteria.

-Evaluation of stickiness in the mouth (immediately after and 2 hours later)-
・ Scoring criteria 1 point: Feel strongly 2 points: Feel 3 points: Do not feel much 4 points: Almost do not feel 5 points: Do not feel at all ・ Evaluation criteria ◎: Average score of 4 people is 4 points or more ○: Average of 4 people Points are 3 points or more and less than 4 points ×: Average score of 4 people is less than 3 points

-Mouth irritation-
・ Scoring criteria 1 point: Very feel 2 points: Feel 3 points: Do not feel much 4 points: Almost do not feel 5 points: Do not feel at all ・ Evaluation criteria ◎: Average score of 4 people is 4 points or more ○: 4 people Average score is 3 points or more and less than 4 points ×: Average score of 4 people is less than 3 points

<Evaluation of storage stability of pharmaceutical product>
-Liquid separation stability-
Three dentifrice compositions contained in a tube container were stored under 40 ° C. conditions for one month, and then judged according to the following scoring criteria and evaluated according to the following criteria.
・ Evaluation criteria ◎: No liquid separation is observed ○: Very few signs of liquid separation are observed (gloss, which is a sign of separation is observed on the surface), but there is no problem in quality ×: Liquid separation is observed Be

-Kneaded skin-
Three dentifrice compositions contained in a tube container were stored at −5 ° C. for 1 month, and then judged according to the following evaluation criteria.
・ Evaluation criteria ◎: Equivalent to the target product, no wrinkles on the surface of the dentifrice composition, and no change in gloss ○: Slight wrinkles or surface surface of the dentifrice composition compared to the target product Slight deterioration is observed in gloss, but there is no problem in quality. ×: Compared to the target product, wrinkles are observed on the surface of the dentifrice composition, and the surface is not glossy, which is a problem in quality.

[Footnotes in Tables 1 to 4]
Abrasive silica: Average particle diameter of about 20 μm

In Comparative Example 1 without sodium lauroyl sarcosine and Comparative Example 2 without sodium pyrophosphate, the evaluation of stickiness in the oral cavity (immediately after 2 hours) was low, whereas sodium lauroyl sarcosine and sodium pyrophosphate were used. All of Examples 1 to 27 that were blended had good evaluations and had an excellent function of suppressing stickiness in the oral cavity. Further, as the dentifrice composition, in the dentifrice compositions of Examples 1 to 24 containing an anionic surfactant and polyethylene glycol, the dentifrices of Examples 25 to 27 not containing any or any of these. Compared with the composition, the irritation sensation was sufficiently suppressed and the dentifrice was also good.
These results show that the present invention effectively functions as an oral anti-stickiness inhibitor, and the dentifrice composition of the present invention has an oral anti-stickiness effect and can be exerted for a long period of time, so that a feeling of cleaning is felt. It is good, and in a more preferable embodiment, it is shown that the irritation feeling is suppressed and the appearance stability is good.

Claims (7)

A dentin composition containing (A) acyl sarcosine or a salt thereof (B) an alkali metal pyrophosphate (C) a nonionic surfactant, and (D) polyethylene glycol. The dentifrice composition according to claim 1, wherein the ratio ((A) / (B)) of the content of the component (A) to the content of the component (B) is 0.003 to 10. The dentifrice composition according to claim 1 or 2, wherein the ratio ((A) / (C)) of the content of the component (A) to the content of the component (C) is 0.002 to 10. The dentifrice according to any one of claims 1 to 3, wherein the ratio ((B) / (C)) of the content of the component (B) to the content of the component (C) is 0.02 to 30. Composition. An oral anti-stickiness inhibitor containing (A) acylsarcosine or a salt thereof, and (B) an alkali metal pyrophosphate. (C) The agent according to claim 5, further containing a nonionic surfactant. (D) The agent according to claim 5 or 6, further containing polyethylene glycol.