WO2023063268A1

WO2023063268A1 - Non-aqueous composition for oral cavity

Info

Publication number: WO2023063268A1
Application number: PCT/JP2022/037695
Authority: WO
Inventors: 麻衣小幡; 弘子工藤
Original assignee: ライオン株式会社
Priority date: 2021-10-11
Filing date: 2022-10-07
Publication date: 2023-04-20
Also published as: JP2023057201A

Abstract

The purpose of the present invention is to provide a non-aqueous composition for the oral cavity, the non-aqueous composition maintaining a warm sensation for an extended period of time when brushing teeth, having no unpleasant bitterness or sweetness, and achieving good usability. The present invention provides a non-aqueous composition for the oral cavity, the non-aqueous composition containing (A) heliotropin and having a water content of 2 mass% or less. It is preferable that the composition additionally contain (B) at least one type of substance selected from glycerin, polyethylene glycol, propylene glycol, and 1,3-butylene glycol, and it is preferable that the component (B) be a combination of (B1) glycerin and (B2) at least one type of substance selected from polyethylene glycol, propylene glycol, and 1,3-butylene glycol. It is preferable that the contained amounts of the components (A) and (B) be 0.01-0.5 mass% and 20-85 mass%, respectively.

Description

Non-aqueous oral composition

The present invention relates to a non-aqueous oral composition.

As a method for imparting a warm sensation to a dentifrice, a method is known in which a solvent other than water is used to impart a warm sensation to the dentifrice due to the heat of hydration of the solvent.

For example, in Patent Document 1, by adding a cooling sensation agent to a polyhydric alcohol-based dentifrice composition containing a combination of predetermined surfactants, in addition to a warm feeling, a conspicuous cooling sensation after use is provided. It states that you can Patent Document 2 discloses that an oral care composition composed of a flavor composition containing tin ions, a mint-type flavor oil, and a predetermined protective agent component can suppress discomfort caused by tin ions, such as malodor and bad taste. is described.

On the other hand, heliotropin (piperonal) is used as a fragrance and is known to have autonomic nerve regulation effects, sleep improvement effects, and stress relief effects (Patent Documents 3 and 4).

Japanese Patent Application Laid-Open No. 2021-31426 JP 2013-32371 A JP 2010-90317 A JP 2007-197334 A

However, although the warm feeling due to the heat of hydration of the solvent is strongly felt at the beginning of polishing, the warm feeling may not last long. there was a case. In addition, although heliotropin is known to be a perfume having a physiological action, it is not known to be involved in imparting warmth.
The present invention has been made in view of the above, and is a non-aqueous oral cavity that has good persistence of warmth during use, reduces unpleasant bitterness and sweetness, and can exhibit a good feeling of use. It is intended to provide a composition.

In order to solve the above problems and achieve the object, the present invention is characterized by the following [1] to [8].
[1] (A) A non-aqueous composition for oral cavity containing heliotropin and having a water content of 2% by mass or less.
[2] The non-aqueous oral composition according to [1], wherein the content of component (A) is 0.01 to 0.5% by mass.
[3] (B) The non-aqueous oral cavity according to [1] or [2], further containing at least one polyhydric alcohol selected from glycerin, polyethylene glycol, propylene glycol, and 1,3-butylene glycol. composition.
[4] component (B) is
(B1) glycerin;
(B2) The non-aqueous oral composition according to [3], which is a combination of at least one selected from polyethylene glycol, propylene glycol, and 1,3-butylene glycol.
[5] The non-aqueous oral cavity composition according to [4], wherein the component (B2) contains at least polyethylene glycol.
[6] The non-aqueous oral composition according to any one of [3] to [5], wherein the content of component (B) is 20 to 85% by mass.
[7] Any one of [4] to [6], wherein the mass ratio (B1/B2) of the content of component (B1) to the content of component (B2) is 0.5 to 20. A water-based oral composition.
[8] The non-aqueous oral composition according to any one of [1] to [7], which is a toothpaste composition.

According to the present invention, it is possible to provide a non-aqueous oral cavity composition that provides a long-lasting warm sensation when brushing teeth, is free from unpleasant bitterness and sweetness, and has a good feeling of use.

The present invention will be described in detail below.

[1. Oral composition]
The composition contains component (A) and preferably further contains component (B).

[(A) Heliotropin]
(A) Component is heliotropin. The origin of heliotropin is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, or the like. If it is naturally derived, its purity is not particularly limited, and components other than heliotropin, such as essential oils and plant extracts, may be used as component (A).

The content of component (A) is preferably 0.008% by mass or more, more preferably 0.01% by mass or more, relative to the total amount of the composition. As a result, it is possible to further improve the continuation of the feeling of warmth. The upper limit is preferably 0.8% by mass or less, more preferably 0.5% by mass or less. This can prevent the unique sweetness of heliotropin from affecting the feeling of use of the non-aqueous oral cavity composition. Therefore, the content of component (A) is preferably 0.008 to 0.8% by mass, more preferably 0.01 to 0.5% by mass.

[(B) Polyhydric alcohol]
(B) Component is a polyhydric alcohol. Polyhydric alcohols are typically liquid polyhydric alcohols at 25° C. that generate heat of hydration when in contact with water. Polyhydric alcohol as component (B) is, for example, glycerin, polyethylene glycol, propylene glycol, 1,3-butylene glycol, diglycerin, polypropylene glycol or a combination of two or more selected from these, glycerin, polyethylene glycol , propylene glycol, 1,3-butylene glycol, or a combination of two or more selected from these is preferred, and a combination of two or more is more preferred. As a combination of two or more, a combination containing glycerin is preferable, and a combination of at least one selected from (B1) glycerin and (B2) polyethylene glycol, propylene glycol, and 1,3-butylene glycol is more preferable. preferable. In the above combination of (B1) and (B2), (B2) preferably contains at least polyethylene glycol.

-Glycerin-
Polyhydric alcohols usually have a bitter taste, but glycerin is relatively less bitter. Therefore, when the component (B) contains at least glycerin, the bitterness of the composition can be suppressed.

-Average molecular weight of polyethylene glycol-
The average molecular weight of polyethylene glycol (the average molecular weight described in Standards for Quasi-Drug Ingredients 2006, the same shall apply hereinafter) is preferably 190-630. Polyethylene glycol having the above-mentioned average molecular weight contributes relatively strongly to the sensation of warmth, so that the intensity of the sensation of warmth can be enhanced. Examples of such polyethylene glycol include polyethylene glycol 200 (average molecular weight 190-210), polyethylene glycol 400 (average molecular weight 380-420), and polyethylene glycol 600 (average molecular weight 570-630).

- Content of (B) -
The content of component (B) is preferably 20% by mass or more, more preferably 30% by mass or more, relative to the total amount of the composition. As a result, it is possible to obtain a feeling of warmth during use and obtain a good wet feeling. The upper limit is preferably 85% by mass or less, more preferably 80% by mass or less. Thereby, a decrease in viscosity can be suppressed, and good usability can be exhibited. Therefore, the content of component (B) is preferably 20 to 85% by mass, more preferably 20 to 80% by mass, still more preferably 30 to 80% by mass.

[B1/B2]
When component (B) is a combination of components (B1) and (B2), the content ratio (B1/B2) of component (B1) to component (B2) is preferably 0.5 or more, more preferably It is 1 or more, and the upper limit is preferably 20 or less, more preferably 18 or less, even more preferably 14 or less, and even more preferably 12 or less. Therefore, B1/B2 is preferably 0.5-20, more preferably 0.5-18, even more preferably 1-14, still more preferably 1-12.

[Non-aqueous]
The composition is a non-aqueous oral composition. As used herein, the term "non-aqueous system" means substantially free of water. preferable. The water content in the non-aqueous oral composition is usually 2% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less. The water content of the oral composition is the ratio (% by mass) of the total water content contained in the raw materials before blending to the total raw materials, or the difference between the dry weight and the dry weight of the oral composition. It can be calculated as a ratio (% by mass) to the original weight.

[Optional component]
The non-aqueous oral composition may contain other components other than the components (A) and (B) as long as the effects of the present invention are not impaired. Other ingredients include, for example, surfactants, sweeteners, flavors, wetting agents, binders, abrasives, pH adjusters, preservatives, medicinal ingredients, oily ingredients, colorants (pigments), and other oral compositions. Ingredients that can be incorporated into the product include, but are not limited to.

-Surfactant-
Examples of surfactants include anionic surfactants, amphoteric surfactants, and nonionic surfactants. Anionic surfactants and amphoteric surfactants are preferred because they can further improve the rising of the warm feeling. Activators are more preferred.

Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, and lauryl sulfoacetate. Alkyl groups and acyl groups may be linear or branched, saturated or unsaturated, and usually have 10 to 20 carbon atoms, preferably 12 to 18 carbon atoms, and more preferably 14 to 16 carbon atoms. Salts may be selected from pharmacologically acceptable salts. Pharmaceutically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts and diisopropylammonium salts; arginine salts and the like. and basic amino acid salts of Among them, inorganic base salts are preferred, alkali metal salts (eg, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Alkyl sulfates include, for example, lauryl sulfate and myristoyl sulfate. Acyl amino acid salts include, for example, acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; N-lauroyl-N-methylglycinate and cocoylglycine. Acylglycine salts such as salts; N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl acylalanine salts such as -N-methyl-β-alanine salts and N-methyl-N-acylalanine salts; and acyl aspartates such as lauroyl aspartate. Acyl taurine salts include, for example, lauroyl methyl taurine salts, N-methyl-N-acyl taurine salts, and N-cocoyl methyl taurine salts. The α-olefin sulfonate includes α-olefin sulfonates having 12 to 18 carbon atoms such as tetradecene sulfonate (α-olefin sulfonic acid having 14 to 16 carbon atoms). Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate.

As the anionic surfactant, α-olefin sulfonate is preferable, and tetradecene sulfonate (α-olefin sulfonic acid having 14 to 16 carbon atoms) is more preferable. Anionic surfactants may be used alone or in combination of two or more.

The content of the anionic surfactant is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, based on the total composition. As a result, the dispersibility of the preparation in the oral cavity is improved during use, and the warm feeling is improved. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. This can reduce the feeling of degreasing in the oral cavity after use. Therefore, it is preferably 0.1 to 3% by mass, more preferably 0.5 to 2% by mass of the total composition.

Examples of amphoteric surfactants include betaine type and amino acid type, with betaine type being preferred. Examples of betaine-type amphoteric surfactants include fatty acid amidopropyl betaine (eg, coconut oil fatty acid amidopropyl betaine), alkyl acetate betaine (eg, alkyl amino acetate betaine such as lauryldimethylamino acetate betaine), and alkylimidazolinium betaine. (eg, alkylcarboxymethylhydroxyethylimidazolinium betaines), fatty acid amidopropylbetaines and alkylacetate betaines are preferred, and coconut oil fatty acid amidopropylbetaines are more preferred. When the amphoteric surfactant has an alkyl group or an acyl group, they may be linear or branched, saturated or unsaturated, and usually have 10 to 20 carbon atoms, preferably 12 to 18 carbon atoms. , more preferably 14-16. The amphoteric surfactant is preferably a solution or powder with a pure content (betaine pure content) of 65% or more. This can facilitate adjustment of the moisture content of the composition.

As the amphoteric surfactant, fatty acid amidoalkyl betaine is preferable, and fatty acid amidopropyl betaine such as coconut oil fatty acid amidopropyl betaine is more preferable. Amphoteric surfactants may be used alone or in combination of two or more.

When an amphoteric surfactant is included, the content is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, based on the total composition. As a result, the feeling of degreasing in the oral cavity is sufficiently improved, and the rise of the feeling of warmth is improved. The upper limit is preferably 3% by mass or less, more preferably 2% by mass or less. As a result, the bitterness is suppressed, and the pleasant feeling of use can be sufficiently maintained. Therefore, 0.1 to 3% by mass is preferable, and 0.3 to 2% by mass is more preferable.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oils, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene Ethylene fatty acid ester, polyoxyethylene alkenyl ether, glycerin fatty acid ester, sucrose fatty acid ester (eg, maltose fatty acid ester), sugar alcohol fatty acid ester (eg, maltitol fatty acid ester, lactitol fatty acid ester), fatty acid diethanolamide (eg, lauryl) acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, polyoxyethylene polyoxypropylene (EOPO) copolymers, alkyl glucosides, fatty acid polyglyceryls. The number of carbon atoms in the alkyl group of the polyoxyethylene alkyl ether is generally 12 to 18, preferably 14 to 18 (eg, lauryl and stearyl groups), and the average number of added moles of ethylene oxide is generally 5 to 30 mol, preferably is 15-30 mol. The average mole number of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is generally 5 to 100 mol, preferably 20 to 100 mol, more preferably 20 to 60 mol. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12-18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is generally 16-18, and the average number of moles of ethylene oxide added is generally 10-40 mol. The alkyl chain of the alkylolamide usually has 12-14 carbon atoms. The polyoxyethylene-polyoxypropylene (EOPO) copolymer preferably has an average added mole number of ethylene oxide of 20 to 210 and an average added mole number of propylene oxide of 15 to 60, and may be a block copolymer or a random copolymer.

The content of the nonionic surfactant is preferably 0.05% by mass or more, more preferably 0.5% by mass or more, based on the total composition. As a result, the feeling of degreasing in the oral cavity can be improved. The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less. As a result, the bitterness can be suppressed, and the pleasant feeling of use can be sufficiently maintained. Therefore, it is preferably 0.05 to 2% by mass, more preferably 0.5 to 1% by mass.

-sweetener-
Sweeteners include, for example, xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, p- methoxycinnamic aldehyde. A sweetener may be used individually by 1 type, and may be used in combination of 2 or more type.

-Perfume-
Flavoring agents include, for example, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil. , lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, Natural fragrances such as absolute peppermint, absolute rose, orange flower, and fragrances obtained by processing these natural fragrances (e.g., pre-reservoir cut, post-reservoir cut, fractional distillation, liquid-liquid extraction, essence conversion, powder perfume preparation), and menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N- substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methyl anthranilate, ethyl methyl phenylglycidate, vanillin, Undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl thioacetate, etc. Strawberry flavor, apple flavor, banana flavor , pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, mixed fruit flavor, and tropical fruit flavor. Perfume may be used individually by 1 type, and may be used in combination of 2 or more type.
It is preferable to use 0.000001 to 1% by mass of the above perfume material in the composition, and 0.1 to 2.0% by mass of the perfume for perfuming using the above perfume material is used in the composition. It's good.

-wetting agent-
Wetting agents include, for example, sugar alcohols. Examples of sugar alcohols include sorbitol (sorbitol) and lactitol. One type of wetting agent may be used, or two or more types may be used in combination. The average molecular weight is the average molecular weight described in the Standards for Quasi-drug Ingredients 2006. The content of the wetting agent is usually 0-20% by weight, preferably 1-10% by weight.

-Binder-
As the binder, for example, an organic binder such as a water-soluble polymer or an inorganic binder can be used. Organic binders include, for example, cellulose-based binders (e.g., carboxymethylcellulose (CMC), sodium salts thereof, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose), and other polysaccharide-based binders. Binders (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, carrageenan, sodium alginate), synthetic water-soluble polymers (e.g., (crosslinked) sodium polyacrylate, carboxyvinyl polymer, polyvinyl alcohol) , propylene glycol alginate). Examples of inorganic binders include thickening silica such as precipitated silica, igneous silica, gelling silica and gelling aluminum silica, and clay minerals such as Veegum, laponite and bentonite, preferably organic clays. Binders, more preferably cellulose-based binders and other polysaccharide-based thickeners, and still more preferably carboxymethylcellulose sodium and carrageenan. The binder may be one or a combination of two or more, preferably a combination of two or more (for example, a combination of a cellulosic binder and another polysaccharide thickener).
The content of the binder is preferably 0.1 to 3% by mass, more preferably 0.1 to 2% by mass, based on the total composition.

-Abrasive-
The abrasive may be, for example, either an inorganic abrasive or an organic abrasive. Examples of inorganic abrasives include abrasive silica such as aluminosilicate, zirconosilicate, crystalline zirconium silicate, and titanium-bonded silica; dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, and tricalcium phosphate. Calcium phosphate-based compounds such as calcium pyrophosphate; Calcium carbonate-based abrasives such as calcium carbonate; Calcium-based abrasives other than carbonate/phosphoric acid, such as calcium hydroxide and calcium sulfate; Aluminum oxide, aluminum hydroxide, alumina and the like Silicic acid-based materials such as silicic anhydride, zeolite, and zirconium silicate; Magnesium-based materials such as magnesium carbonate and trimagnesium phosphate; Apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; Titanium dioxide , mica titanium, titanium oxide and other titanium-based materials; and bentonite and other minerals. Examples of organic abrasives include polymethyl methacrylate and synthetic resin abrasives. Among these, abrasive silica and calcium phosphate compounds are preferred, and silicic anhydride is more preferred. One type of abrasive may be used, or two or more types may be used in combination.
The compounding amount of the abrasive is usually 0 to 70% by mass, preferably 2 to 30% by mass, based on the total composition.

-pH adjuster-
Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or salts thereof; inorganic acids such as phosphoric acid (orthophosphoric acid), or salts thereof ( For example, potassium salt, sodium salt and ammonium salt); hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

-Preservative-
Examples of preservatives include paraoxybenzoic acid esters (eg, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate) and sodium benzoate. The preservatives may be used singly or in combination of two or more.

-Medicinal Ingredients-
Examples of medicinal ingredients include nonionic fungicides (eg, isopropylmethylphenol), cationic fungicides (eg, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride), zinc gluconate, zinc citrate, triclosan, Bactericidal or antibacterial agents such as hinokitiol, lysozyme chloride, chlorhexidine salts, trichlorocarbanilide; enzymes such as dextranase, mutanase, amylase, protease, litek enzyme, coenzyme Q10; sodium fluoride, sodium monofluorophosphate, fluoride Fluorides such as stannous; Inflammatory agents; metal salts such as zinc, copper salts and tin salts; water-soluble phosphoric acid compounds such as potassium salt and sodium salt of orthophosphate; chelating phosphoric acid compounds such as glycerophosphate; anticalculus agents such as phosphonates; blood flow promoters such as vitamin E (e.g., tocopherol acetate such as dl-α-tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; hydroxyethyl cellulose dimethyl diallyl coating agents such as ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salts) and sodium chloride; copper compounds such as copper chlorophyll and copper gluconate; anticalculus agents, amino acids such as alanine, glycine, and proline ; Angelica soft extract, Phellodendron bark extract, chamomile, clove, rosemary, Scutellaria root, safflower, thyme, Scutellaria root, clove, hamamelis plant extract; Calopeptide, polyvinylpyrrolidone, hydroxamic acid and its derivatives, tripolyphosphate, methoxyethylene maleic anhydride Mention may be made of acid copolymers, sodium chloride, chlorophyll, sanguinarine extract, berberine, hydroxamic acid and its derivatives, pyrophosphates, zeolites, epidihydrocholesterin, trichlorocarbanilides, zinc citrate. A medicinal ingredient may be used individually by 1 type, and may be used in combination of 2 or more type. The content of the medicinal ingredient can be appropriately set to an effective amount according to a conventional method within a range that does not impair the effects of the present invention.

- Oily component -
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, microcrystalline wax, carnauba wax, rice wax, and rosin; higher alcohols (such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, iso Alcohols with 8 to 22 carbon atoms such as stearyl alcohol); higher fatty acids (for example, fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, isostearic acid), olive oil, castor oil, coconut oil, etc. and fatty acid esters such as isopropyl myristate.

-coloring agent-
The non-aqueous oral composition of the present embodiment may contain any suitable conventionally known coloring agent in any suitable content. Examples of colorants that may be included in the non-aqueous oral cavity composition include safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, monascus pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, and spirulina blue pigment. , Natural pigments such as tamarind pigment, Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, Blue 4 No. 5, riboflavin, and sodium copper chlorophyllin.
When the non-aqueous oral composition contains a coloring agent, the content thereof is preferably 0.00001 to 3% by mass based on the total non-aqueous oral composition.

The non-aqueous oral composition can be used, for example, as a toothpaste such as a toothpaste, a gel-like toothpaste, a liquid toothpaste, a liquid toothpaste, and a toothpaste, preferably a toothpaste.

The dosage form of the non-aqueous oral composition can be appropriately selected according to the usage form, and is not particularly limited. Dosage forms include, for example, gels and pastes.

[Method for producing non-aqueous oral composition]
The method for producing the non-aqueous oral composition is not particularly limited, and it can be prepared by each usual method depending on the dosage form. For example, when it is used as a toothpaste, there is a method of preparing components that dissolve in a solvent, mixing other insoluble components, and defoaming (for example, reducing pressure) as necessary. The obtained toothpaste can be stored in a container to be used as a product. The shape and material of the container are not particularly limited, and containers commonly used for toothpaste compositions can be used, examples of which include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon.

The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, % in the table indicates % by mass unless otherwise specified.

[Main raw materials used in Examples and Comparative Examples]
(A) Heliotropin: Takasago Perfumery Co., Ltd. (B1) Concentrated glycerin (99.5%): Sakamoto Pharmaceutical Co., Ltd., concentrated glycerin for cosmetics (B2-1) Polyethylene glycol 400: Sanyo Chemical Industries, Ltd. ), polyethylene glycol 400
(B2-2) Propylene glycol: manufactured by ADEKA (B2-3) 1,3-butylene glycol: manufactured by Kokyu Alcohol Kogyo Co., Ltd. (components other than (A) and (B-1))
Sodium tetradecene sulfonate: K Liporan PJ-400CJ, manufactured by Lion Specialty Chemicals
Coconut fatty acid amidopropyl betaine: manufactured by Evonik, TEGO Betain CK D, product composition (coconut fatty acid amidopropyl betaine: sodium chloride: water = 85:14.5:0.5, betaine pure content: 85%)
Sodium monofluorophosphate: manufactured by ICL JAPAN Saccharin sodium: manufactured by Aisan Chemical Industry Co., Ltd. Silica: manufactured by Solvay, Tixosil (registered trademark) 73 (average particle size (volume basis D50): 9 μm)
Carrageenan: manufactured by CPKelco, GENUVISCO (registered trademark) carrageenan type TPC-1
Carboxymethylcellulose sodium: CMC1260, manufactured by Daicel Finechem Co., Ltd.
For other ingredients, those conforming to the Standards for Quasi-drug Ingredients 2006 were used.

Examples 1-9 and Comparative Examples 1-3 (toothpaste)
A toothpaste composition was prepared according to the following preparation method. The composition of each example is shown in Tables 1 to 5 (unit: % by mass). When the water content of the composition was calculated as the ratio (% by mass) of the total water content contained in the raw materials before blending to the total raw materials, it was 2% by mass or less.

[Method for preparing dentifrice composition]
Raw materials were blended by a conventional method, mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Kosakusho Co., Ltd.), and degassed under reduced pressure (pressure 4 kPa) to obtain a dentifrice composition.

[Evaluation method]
The obtained dentifrice compositions were evaluated as follows.

-Evaluation of the sustained feeling of warmth when brushing teeth-
1 g of the dentifrice composition was placed on a toothbrush (clinica advantage toothbrush, 4-row compact normal, manufactured by Lion Corporation; the same applies to the toothbrushes used in the following evaluation methods), and the warm feeling when brushing was performed in the usual manner. The lasting feeling was evaluated on a scale of 5 according to the rating criteria shown below. The average score of the 7 testers was calculated and shown in a table with ++, +, -, - according to the following evaluation criteria.

(Rating criteria)
5 points: There is a feeling that the warm feeling lasts for a long time (15 seconds or more after starting to feel the warm feeling)
4 points: There is a feeling that the warm sensation lasts a little longer (10 seconds or more to less than 15 seconds after starting to feel the warm sensation)
3 points: There is a feeling of continuous warmth (5 seconds or more to less than 10 seconds after starting to feel warmth)
2 points: There is a slight feeling of warmth (2 seconds or more to less than 5 seconds after starting to feel warmth)
1 point: no feeling of continuous warmth (less than 2 seconds after starting to feel warmth, or no sensation of warmth)
(Rating)
++: average 4.5 points or more +: average 4.0 points or more and less than 4.5 points -: average 3.0 points or more and less than 4.0 points --: average 1.0 points or more and less than 3.0 points

-Evaluation of unpleasant bitterness and lack of sweetness during toothbrushing-
When 1 g of the dentifrice composition was placed on a toothbrush and brushed in the usual manner, the absence of unpleasant bitterness and sweetness was evaluated on a scale of 5 according to the rating criteria shown below. The average score of the 7 testers was calculated and shown in a table with ++, +, -, - according to the following evaluation criteria.

(Evaluation criteria)
5 points: Absolutely no unpleasant bitterness or sweetness 4 points: Slightly unpleasant bitterness, sweetness, or both, but not unpleasant 3 points: Unpleasant bitterness, sweetness, or both, slightly unpleasant Yes 2 points: feel unpleasant bitterness, sweetness, or both 1 point: strongly feel unpleasant bitterness and sweetness
(Rating)
++: average 4.5 points or more +: average 4.0 points or more and less than 4.5 points -: average 3.0 points or more and less than 4.0 points --: average 1.0 points or more and less than 3.0 points

[Table annotation]
*: Does not feel warm

Compared to the comparative examples, the dentifrices of Examples 1 to 9, which contain heliotropin and have a water content of 2% by mass or less, are good in both a sustained feeling of warmth when brushing teeth and an absence of unpleasant bitterness and sweetness. there were.
These results show that according to the present invention, unpleasant bitterness and sweetness during toothbrushing can be suppressed, and warm sensation can be maintained for a long time.

Claims

(A) A non-aqueous oral composition containing heliotropin and having a water content of 2% by mass or less.
The non-aqueous oral cavity composition according to claim 1, wherein the content of component (A) is 0.01 to 0.5% by mass.
(B) The non-aqueous oral composition according to claim 1 or 2, further comprising at least one polyhydric alcohol selected from glycerin, polyethylene glycol, propylene glycol, and 1,3-butylene glycol.
(B) component is
(B1) glycerin;
(B2) The non-aqueous oral composition according to claim 3, which is a combination of at least one selected from polyethylene glycol, propylene glycol, and 1,3-butylene glycol.
The non-aqueous oral composition according to claim 4, wherein the component (B2) contains at least polyethylene glycol.
The non-aqueous oral composition according to any one of claims 3 to 5, wherein the content of component (B) is 20 to 85% by mass.
The non-aqueous oral composition according to any one of claims 4 to 6, wherein the mass ratio (B1/B2) of the content of component (B1) to the content of component (B2) is 0.5 to 20. .
The non-aqueous oral composition according to any one of claims 1 to 7, which is a toothpaste composition.