JP7180600B2 - dentifrice composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a dentifrice composition excellent in imparting gloss to teeth and tightening feeling of gums.

Techniques using 1,1-methylene-bis-(4-isocyanatohexane)/propylene glycol copolymers and the like for oral compositions that give gloss to teeth (Patent Document 1: International Publication No. 2012/165434) , a technique using phytic acid (Patent Document 2: Japanese Patent No. 5860572), and the like have been proposed.

On the other hand, a composition containing a copper compound or a zinc compound has been proposed as an oral composition that imparts an astringent effect (Patent Document 3: JP-A-2011-105682). However, there has been no proposal for an oral cavity composition that imparts luster to teeth and provides an excellent feeling of tightening to the gums.

WO2012/165434 Japanese Patent No. 5860572 JP 2011-105682 A

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition that imparts luster to teeth and provides an excellent feeling of tightening gums.

As a result of intensive studies to achieve the above object, the present inventors have found that the above problems can be solved by using (A) charcoal powder and (B) a zinc compound together, and have completed the present invention. It is. By combining the component (A), which has not been known to have a glossing effect on teeth and the effect of tightening gums, and the component (B), which has not been known to have a glossing effect on teeth, It is a new finding of the present inventors that gloss impartation and the feeling of tightening the gums are synergistically improved.

Accordingly, the present invention provides the following dentifrice compositions and brightening agents.
[1]. A dentifrice composition containing (A) charcoal powder and (B) a zinc compound.
[2]. The dentifrice composition according to [1], wherein the component (A) is bamboo charcoal or Bincho charcoal powder.
[3]. The dentifrice composition according to [1] or [2], wherein the component (A) has a volume average particle size (d50) of 0.5 to 15 μm.
[4]. The dentifrice composition according to any one of [1] to [3], wherein component (B) is a zinc compound selected from zinc citrate and zinc oxide.
[5]. The dentifrice composition according to any one of [1] to [4], further comprising (C) polyethylene glycol.
[6]. A tooth brightener comprising (A) charcoal powder and (B) a zinc compound.

To provide an oral cavity composition imparting luster to teeth and excellent in tightening feeling of gums.

The present invention will be described in detail below.
(A) Charcoal powder The charcoal raw material for the charcoal powder is not particularly limited, and known charcoal such as bamboo charcoal, Bincho charcoal, and activated carbon can be used, either singly or in combination of two or more. can be used Among them, bamboo charcoal or Bincho charcoal powder is preferable.

<Particle size>
As for the particle size of the charcoal powder, the volume average particle size (d50: median diameter) is 0.5 to 15 μm, preferably 0.5 to 5 μm, more preferably 0.5 to 3 μm. The particle size is measured using a laser diffraction/scattering particle size distribution analyzer, for example, Microtrac MT3000II, manufactured by NIKKISO. By setting the volume average particle size (d50) to 0.5 μm or more, it is possible to obtain a greater effect of imparting gloss to teeth, but if the particle size is too large, the appearance of the composition may be affected.

The amount of component (A) is preferably 0.0001 to 0.1% by mass, more preferably 0.001 to 0.05% by mass, and 0.002 to 0.04% by mass relative to the total amount of the dentifrice composition. is more preferred, and 0.005 to 0.01% by mass is particularly preferred. By setting the blending amount to 0.0001% by mass, it is possible to obtain a greater effect of imparting gloss to teeth. If the amount is too large, the appearance of the composition may be affected, and other effects such as adsorption of other components may occur.

(B) Zinc compound Zinc compounds include zinc compounds such as zinc citrate, zinc oxide, zinc sulfate, zinc chloride, zinc gluconate, zinc malate, zinc tartrate, zinc carbonate, and zinc phosphate. It can be used alone or in appropriate combination of two or more. Among them, zinc citrate and zinc oxide are preferred.

The blending amount of component (B) is preferably 0.1 to 5% by mass, more preferably 0.5 to 2% by mass, based on the total amount of the dentifrice composition. By setting the blending amount to 0.1% by mass or more, the effect of imparting gloss to the teeth and the feeling of tightening of the gums are further improved. If the amount is too large, the appearance of the composition may be affected, or the composition may have an unpleasant taste.

The mass ratio of component (A) to component (B) represented by (B)/(A) is preferably 10 to 500, more preferably 50 to 200, from the viewpoint of the effects of the present invention.

(C) Polyethylene glycol The dentifrice composition of the present invention preferably contains polyethylene glycol in order to further improve the effect of imparting gloss to teeth. As polyethylene glycol, those having an average molecular weight of 200 to 6,000 are preferable, and those having an average molecular weight of 180 to 630 are more preferable. By using a substance in such a range, the effect of imparting gloss is further improved. In addition, the average molecular weight indicates the average molecular weight described in Standards for Quasi-drug Ingredients 2006 (hereinafter the same). Specifically, polyethylene glycol 200 (average molecular weight 180-220), polyethylene glycol 300 (average molecular weight 260-340), polyethylene glycol 400 (average molecular weight 380-420), polyethylene glycol 600 (average molecular weight 570-630), polyethylene Glycol 4000 (average molecular weight 2,600 to 3,800) can be exemplified. These can be used individually by 1 type or in combination of 2 or more types as appropriate.

The amount of component (C) when blended is preferably 1 to 10% by mass, more preferably 1.5 to 7% by mass, and even more preferably 1.5 to 5% by mass, relative to the total amount of the dentifrice composition.

The dentifrice composition of the present invention can contain various components that can be blended in the dentifrice composition as long as the effects of the present invention are not impaired. Examples thereof include abrasives, surfactants, wetting agents other than component (C), binders, flavoring agents, sweetening agents, active ingredients, and water. These can each be used individually by 1 type, or in combination of 2 or more types as appropriate.

Abrasives are advantageous in terms of the glossing effect of the present invention, since they clean the tooth surfaces (remove stains and make them smooth without irregularities). Types of abrasives include silicic anhydride, calcium carbonate, calcium phosphate, aluminum hydroxide and the like. Among them, anhydrous silicic acid and calcium carbonate are preferable. When an abrasive is blended, the blending amount is preferably 10 to 50% by mass, more preferably 5 to 45% by mass, based on the total amount of the dentifrice composition.

As surfactants, anionic surfactants, nonionic surfactants, cationic surfactants and amphoteric surfactants generally used in dentifrice compositions can be blended.
Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, N-acylsarcosinates such as sodium N-lauroylsarcosinate, N-acylglutamates, and α-olefinsulfonates. be done.
Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, poly Oxyethylene hydrogenated castor oil, polyoxyethylene higher alcohol ethers, fatty acid alkanolamides and the like can be mentioned.
Cationic surfactants include alkylammonium, alkylbenzylammonium and the like, and amphoteric surfactants include betaine acetates such as alkylbetaines and betaine alkyldimethylaminoacetate, betaines such as alkylimidazolinium betaine, An imidazoline system is mentioned.
When a surfactant is blended, the blending amount is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, based on the total amount of the dentifrice composition.

Wetting agents other than component (C) include sugar alcohols such as sorbitol and polyhydric alcohols such as glycerin and propylene glycol. When blended with a humectant, the blending amount is preferably 2 to 20% by mass based on the total amount of the dentifrice composition.

Examples of the binder include thickening silica such as gelling silica, cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose and hydroxymethylcellulose, alginic acid derivatives such as sodium alginate, xanthan gum, carrageenan, and sodium polyacrylate. The amount of the binder when blended is preferably 2 to 50% by mass based on the total amount of the dentifrice composition.

Flavors include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural flavors such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, etc., and processing of these natural flavors perfumed, etc.), and menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, Menthone, menthyl acetate, N-substituted-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl Single fragrances such as methyl phenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate, strawberry flavor, apple flavor, banana Flavors, pineapple flavors, grape flavors, mango flavors, butter flavors, milk flavors, mixed fruit flavors, tropical fruit flavors, and other known flavor materials used in dentifrice compositions can be used in combination. In addition, when the above-mentioned perfume material is blended, it is preferable to use 0.000001 to 1% by mass based on the total amount of the dentifrice composition. When blending the perfume for flavoring using the above perfume material, it is preferable to use 0.1 to 2% by mass of the total amount of the dentifrice composition.

Examples of sweetening agents include saccharin sodium and the like, and examples of preservatives include parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, benzoic acid and salts thereof, and the like.

Active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, nonionic fungicides such as isopropylmethylphenol, cationic fungicides such as cetylpyridinium chloride, benzalkonium chloride and benzethonium chloride, and tranexamic acid. , epsilon aminocaproic acid, anti-inflammatory agents such as allantoin, enzymes such as dextranase and mutanase, water-soluble phosphoric acid compounds, water-soluble copper compounds, potassium nitrate, aluminum lactate, ascorbic acid or its derivatives, vitamins, and the like. When the active ingredient is blended, the blending amount is an effective amount as long as the effects of the present invention are not impaired.

Water is not particularly limited, and the amount of water when blended is preferably 20 to 45% by mass based on the total amount of the dentifrice composition.

[Production method]
The dentifrice composition of the present invention can be obtained by manufacturing according to a conventional method, for example, the method shown in the following examples.

[Glossing agent]
Also, the composition containing (A) the charcoal powder and (B) the zinc compound has an excellent effect of imparting gloss to teeth. Accordingly, the present invention provides a tooth brightening agent containing (A) charcoal powder and (B) a zinc compound. Suitable ingredients and amounts are the same as above.

EXAMPLES Hereinafter, the present invention will be specifically described by showing examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, unless otherwise specified, "%" in the composition indicates mass %, and ratio indicates mass ratio.

[Examples, Comparative Examples]
A dentifrice composition having the composition shown in Tables 1 to 4 was produced according to a conventional method for producing a toothpaste. The obtained dentifrice composition was filled in a tube container (a tube container generally used for dentifrices without a partition wall inside the container) to obtain a dentifrice preparation.
Compositions 1 and 2 having compositions shown in Table 5 were each produced according to the standard method for producing toothpaste. In a striped dentifrice filling machine, composition 1 and composition 2 are transferred into their respective hoppers and placed adjacent to each other in a striped fashion without intermixing into tube containers (common for dentifrices without partition walls within the container). A tube container) was filled to obtain a striped dentifrice preparation.
The obtained dentifrice formulation and striped dentifrice formulation were evaluated as follows.

The raw materials used are as follows. In addition, unless otherwise specified, the amount of each component in the table is the amount in terms of pure content.
(A) Charcoal powder Bamboo charcoal powder: Bamboo charcoal powder (d50 = 1 µm, 4 µm, 15 µm) manufactured by Cooperative Union Latest: Particle size measuring equipment: Microtrac MT3000II, manufactured by NIKKISO (B) Zinc zinc chloride: P.I. T. INDO LYSAGHT, zinc oxide
Zinc citrate: Jungbunzlauer Austria AG, Zinc Citrate
(C) polyethylene glycol: polyethylene glycol 400

(1) Method for evaluating tooth gloss imparting effect A sensory test was conducted using 10 expert panelists to evaluate the gloss imparting effect on maxillary anterior teeth 1-1 due to continuous use of the test dentifrice composition. The test dentifrice composition was extruded 1 cm onto the toothbrush and brushed three times a day for 3 minutes for 2 weeks in the same way as usual. Thereafter, the effect of imparting gloss is evaluated based on the following <rating>, and the results are shown according to the following <evaluation criteria> based on the obtained average score of 10 people.
<Rating>
5 points: Remarkably glossy compared to before use 4 points: Glossy compared to before use 3 points: Slightly glossy compared to before use 2 points: No change in gloss compared to before use 1 point: Felt less glossy than before use <Evaluation criteria>
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 or more and less than 4.0 points ×: Average score of 10 people is less than 3.0 points "◎", "○ ” will pass.

(2) Evaluation Method for Gums Tightening (Gum Care Feeling) Effect Gums tightening (gum care feeling) after using the test dentifrice composition was evaluated by a sensory test using 10 expert panelists. Extrude 1 cm of the test dentifrice composition onto the toothbrush, brush the teeth for 3 minutes in the same manner as usual, and then evaluate the gum tightening (gums care feeling) effect based on the following <rating>. Based on the average score, the results are shown according to the following <evaluation criteria>.
<Rating>
5 points: The feeling of gum tightening is very high 4 points: The feeling of gum tightening is high 3 points: The feeling of gum tightening is felt 2 points: The feeling of gum tightening is hardly felt 1 point: There is no feeling of gum tightening< Evaluation Criteria>
◎: Average score of 10 people is 4.0 points or more ○: Average score of 10 people is 3.0 or more and less than 4.0 points △: Average score of 10 people is 2.0 or more and less than 3.0 points × : If the average score of 10 people is less than 2.0 points, "◎" and "○" will pass.

(3) Evaluation of Appearance A sensory test was conducted using 10 panelists to evaluate the beauty of the appearance of the test dentifrice composition. Extrude 1 cm of the test dentifrice composition onto a toothbrush, then evaluate the appearance based on the following <rating>, and show the results according to the following <evaluation criteria> based on the average score obtained by 10 people.
<Rating>
3 points: Uniform and beautiful coloring 2 points: Slightly lacking uniformity but no problem 1 point: Non-uniform and uncomfortable coloring <Evaluation criteria>
A: The average of 10 people is 2.5 or more. B: The average of 10 people is 2.0 or more and less than 2.5. ×: The average of 10 people is less than 2.0.

比較例１は（Ａ）成分を配合していないため、外観を評価していない。

Comparative Example 1 did not contain component (A), so the appearance was not evaluated.

The following dentifrice composition was obtained by a conventional method. It was a dentifrice composition having a "glossing effect" and a "gum-tightening effect" as in the above Examples, and a beautiful "appearance".
[Prescription example 1]
Composition (%)
(A) Bamboo charcoal powder (1 μm) 0.01
(B) zinc oxide 1
(C) polyethylene glycol 2005
Isopropyl methylphenol 0.1
Sodium fluoride 0.22
Sorbit solution (70%) 35
Silica (abrasive) 25
Silica (thickening) 1.5
Carrageenan 0.3
Carboxymethylcellulose sodium 0.9
Sodium lauryl sulfate 1.5
Perfume 1.2
Titanium oxide 0.5
Sodium citrate 0.5
Saccharin sodium 0.35
Butylparaben 0.01
water
Total 100.0

[Prescription Example 2]
Composition (%)
(A) Bamboo charcoal powder (1 μm) 0.01
(B) zinc oxide 1
(C) polyethylene glycol 4000 1
Isopropylmethylphenol 0.05
Sodium fluoride 0.3
Sorbit solution (70%) 35
Silica (abrasive) 25
Silica (thickening) 1.5
Carrageenan 0.3
Carboxymethylcellulose sodium 0.9
Sodium Lauryl Sulfate 2
Perfume 1.2
Titanium oxide 0.5
Sodium citrate 0.5
Saccharin sodium 0.35
Methylparaben 0.01
water
Total 100.0

Claims (6)

A dentifrice composition containing (A) a charcoal powder having a volume average particle size (d50) of 0.5 to 15 μm, and (B) a zinc compound. 2. The dentifrice composition according to claim 1, wherein component (A) is bamboo charcoal or Binchotan charcoal powder. The dentifrice composition according to claim 1 or 2, wherein component (A) has a volume average particle size (d50) of 0.5 to 5 µm. The dentifrice composition according to any one of claims 1 to 3, wherein component (B) is a zinc compound selected from zinc citrate and zinc oxide. The dentifrice composition according to any one of claims 1 to 4, further comprising (C) polyethylene glycol. (A) A charcoal powder having a volume average particle size (d50) of 0.5 to 15 μm, and (B) a tooth brightening agent containing a zinc compound.